{"title":"Exploring the 3D Bioprinting Landscape in the Delivery of Active Pharmaceutical Compounds for Therapeutic and Regenerative Medicine Applications","authors":"Khonzisizwe Somandi, Yahya E. Choonara","doi":"10.1002/jbm.b.35654","DOIUrl":null,"url":null,"abstract":"<p>Three-dimensional (3D) bioprinting is transforming the delivery of active pharmaceutical compounds and regenerative medicine by enabling patient-specific solutions that enhance treatment efficacy and safety. This review explores recent advancements in 3D bioprinting for targeted therapy, focusing on its ability to fabricate complex delivery systems of drugs, cells, and various biomolecules with controlled and sustained release profiles. By leveraging bioinks with tunable properties, 3D bioprinting allows for localized drug administration, reducing systemic side effects while improving bioavailability. Additionally, in situ 3D bioprinting facilitates the direct deposition of therapeutic agents at the site of injury or disease, enhancing precision medicine approaches and supporting tissue regeneration. The integration of biocompatible bioinks and nanomedicines minimizes toxicity, enhances drug retention, reduces adverse effects, and enables personalized treatments, significantly improving therapeutic outcomes and, in some cases, improving pharmacokinetics. Despite these advancements, challenges remain in obtaining ideal biomaterial properties, post-printing modifications, printability, and biodegradability, which are critical for clinical translation. Addressing these barriers will be key to expanding the application of 3D bioprinting in precision medicine. This review provides insights into the recent pre-clinical progress, current clinical milestones, limitations, and future directions of 3D bioprinted delivery systems of active pharmaceutical compounds, highlighting their potential to revolutionize patient-centered therapies.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 10","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35654","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomedical materials research. Part B, Applied biomaterials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35654","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Three-dimensional (3D) bioprinting is transforming the delivery of active pharmaceutical compounds and regenerative medicine by enabling patient-specific solutions that enhance treatment efficacy and safety. This review explores recent advancements in 3D bioprinting for targeted therapy, focusing on its ability to fabricate complex delivery systems of drugs, cells, and various biomolecules with controlled and sustained release profiles. By leveraging bioinks with tunable properties, 3D bioprinting allows for localized drug administration, reducing systemic side effects while improving bioavailability. Additionally, in situ 3D bioprinting facilitates the direct deposition of therapeutic agents at the site of injury or disease, enhancing precision medicine approaches and supporting tissue regeneration. The integration of biocompatible bioinks and nanomedicines minimizes toxicity, enhances drug retention, reduces adverse effects, and enables personalized treatments, significantly improving therapeutic outcomes and, in some cases, improving pharmacokinetics. Despite these advancements, challenges remain in obtaining ideal biomaterial properties, post-printing modifications, printability, and biodegradability, which are critical for clinical translation. Addressing these barriers will be key to expanding the application of 3D bioprinting in precision medicine. This review provides insights into the recent pre-clinical progress, current clinical milestones, limitations, and future directions of 3D bioprinted delivery systems of active pharmaceutical compounds, highlighting their potential to revolutionize patient-centered therapies.
期刊介绍：
Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats:
• original research reports
• short research and development reports
• scientific reviews
• current concepts articles
• special reports
• editorials
Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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