{"title":"电刷镀镁在不同环境下的腐蚀行为分析：非血肿与血肿","authors":"Yu Yusa, Yoshinaka Shimizu, Yoshimoto Okada, Masanobu Hayashi, Takayuki Aizawa, Mayuko Izumi, Akimitsu Sato, Chieko Miura, Yoshimichi Imai","doi":"10.1002/jbm.b.35622","DOIUrl":null,"url":null,"abstract":"<p>The corrosion rate of these alloys is observed to be the fastest immediately after implantation. In addition, bleeding can accelerate corrosion and cause treatment failure in vivo, and therefore, it is necessary to optimize the corrosion rate. The brushite (CaHPO<sub>4</sub>・2H<sub>2</sub>O) coating treatment, a type of calcium phosphate, is used as a method to optimize the corrosion rate of magnesium and is expected to have the same coating effect under hematoma as under non-hematoma conditions. The purpose of this study was to evaluate the effect of brushite coating treatment with and without hematoma up to 14 days of implantation in vivo experiments. Specimens of cylindrical Pure Magnesium (99.9%, 1.2 mm × 6 mm), treated with a brushite coating by precipitation, were implanted in hematoma or non-hematoma rat femurs. The insoluble salts that precipitated on the specimens were analyzed by inductively coupled plasma mass spectrometry, scanning electron microscopy-energy dispersive X-ray analysis, and Raman spectroscopy. Results showed that weight loss at 14 days of implantation in the hematoma group (24.83 ± 2.26 μg mm<sup>−2</sup>) was significantly greater than in the non-hematoma group (18.88 ± 1.95 μg mm<sup>−2</sup>). The hematoma group had increased precipitation of insoluble salt magnesium and phosphorus. However, the amount of magnesium contained in insoluble salt per weight loss was significantly greater in the non-hematoma group at all time points, particularly after 1 days of implantation (non-hematoma group: 19.42% ± 3.56%; hematoma group: 10.73% ± 0.41%, <i>p</i> < 0.01). The brushite coating transformed the insoluble salts in the surface layer to an optimum structure compatible with the implantation environment. This enhanced the coating's protective function and more effectively inhibited magnesium corrosion. Given the clinical challenge of fully controlling intra-and postoperative bleeding, a brushite coating adaptable to hematoma conditions offers significant utility.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 8","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35622","citationCount":"0","resultStr":"{\"title\":\"Analysis of Corrosion Behavior of Brushite-Coated Magnesium in Different Environments: Non-Hematoma vs. Hematoma\",\"authors\":\"Yu Yusa, Yoshinaka Shimizu, Yoshimoto Okada, Masanobu Hayashi, Takayuki Aizawa, Mayuko Izumi, Akimitsu Sato, Chieko Miura, Yoshimichi Imai\",\"doi\":\"10.1002/jbm.b.35622\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The corrosion rate of these alloys is observed to be the fastest immediately after implantation. In addition, bleeding can accelerate corrosion and cause treatment failure in vivo, and therefore, it is necessary to optimize the corrosion rate. The brushite (CaHPO<sub>4</sub>・2H<sub>2</sub>O) coating treatment, a type of calcium phosphate, is used as a method to optimize the corrosion rate of magnesium and is expected to have the same coating effect under hematoma as under non-hematoma conditions. The purpose of this study was to evaluate the effect of brushite coating treatment with and without hematoma up to 14 days of implantation in vivo experiments. Specimens of cylindrical Pure Magnesium (99.9%, 1.2 mm × 6 mm), treated with a brushite coating by precipitation, were implanted in hematoma or non-hematoma rat femurs. The insoluble salts that precipitated on the specimens were analyzed by inductively coupled plasma mass spectrometry, scanning electron microscopy-energy dispersive X-ray analysis, and Raman spectroscopy. Results showed that weight loss at 14 days of implantation in the hematoma group (24.83 ± 2.26 μg mm<sup>−2</sup>) was significantly greater than in the non-hematoma group (18.88 ± 1.95 μg mm<sup>−2</sup>). The hematoma group had increased precipitation of insoluble salt magnesium and phosphorus. However, the amount of magnesium contained in insoluble salt per weight loss was significantly greater in the non-hematoma group at all time points, particularly after 1 days of implantation (non-hematoma group: 19.42% ± 3.56%; hematoma group: 10.73% ± 0.41%, <i>p</i> < 0.01). The brushite coating transformed the insoluble salts in the surface layer to an optimum structure compatible with the implantation environment. This enhanced the coating's protective function and more effectively inhibited magnesium corrosion. Given the clinical challenge of fully controlling intra-and postoperative bleeding, a brushite coating adaptable to hematoma conditions offers significant utility.</p>\",\"PeriodicalId\":15269,\"journal\":{\"name\":\"Journal of biomedical materials research. 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Part B, Applied biomaterials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35622","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Analysis of Corrosion Behavior of Brushite-Coated Magnesium in Different Environments: Non-Hematoma vs. Hematoma
The corrosion rate of these alloys is observed to be the fastest immediately after implantation. In addition, bleeding can accelerate corrosion and cause treatment failure in vivo, and therefore, it is necessary to optimize the corrosion rate. The brushite (CaHPO4・2H2O) coating treatment, a type of calcium phosphate, is used as a method to optimize the corrosion rate of magnesium and is expected to have the same coating effect under hematoma as under non-hematoma conditions. The purpose of this study was to evaluate the effect of brushite coating treatment with and without hematoma up to 14 days of implantation in vivo experiments. Specimens of cylindrical Pure Magnesium (99.9%, 1.2 mm × 6 mm), treated with a brushite coating by precipitation, were implanted in hematoma or non-hematoma rat femurs. The insoluble salts that precipitated on the specimens were analyzed by inductively coupled plasma mass spectrometry, scanning electron microscopy-energy dispersive X-ray analysis, and Raman spectroscopy. Results showed that weight loss at 14 days of implantation in the hematoma group (24.83 ± 2.26 μg mm−2) was significantly greater than in the non-hematoma group (18.88 ± 1.95 μg mm−2). The hematoma group had increased precipitation of insoluble salt magnesium and phosphorus. However, the amount of magnesium contained in insoluble salt per weight loss was significantly greater in the non-hematoma group at all time points, particularly after 1 days of implantation (non-hematoma group: 19.42% ± 3.56%; hematoma group: 10.73% ± 0.41%, p < 0.01). The brushite coating transformed the insoluble salts in the surface layer to an optimum structure compatible with the implantation environment. This enhanced the coating's protective function and more effectively inhibited magnesium corrosion. Given the clinical challenge of fully controlling intra-and postoperative bleeding, a brushite coating adaptable to hematoma conditions offers significant utility.
期刊介绍：
Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats:
• original research reports
• short research and development reports
• scientific reviews
• current concepts articles
• special reports
• editorials
Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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