Development of a Novel Janus Biogel Bolus for Radiotherapy

IF 3.4 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2025-07-28 DOI:10.1002/jbm.b.35621

Ying Lu, Shihang Li, Guobao Pang, Xin Yang, Guannan Zhang, Yannan Xu, Jia Li, Qinying Shi, Jianbo Song

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引用次数: 0

Abstract

Bolus is crucial for treating superficial lesions in radiotherapy. However, mechanical adhesion and biological mismatches of Bolus materials often impact the outcome of radiotherapy. This study introduces asymmetrical Janus biogel Bolus with one adhesive side and another with minimal adhesion. The biogel was fabricated employing a synergistic combination of distinct materials through physical and chemical interactions. The upper layer mainly comprises acrylamide and trehalose, abbreviated as PT, while the lower layer consists of acrylamide, trehalose, protocatechuic acid, nanoclay, and resveratrol, abbreviated as PTPNR. Mechanical, biological, and radiological tests were conducted to evaluate the Janus patch as a functional and biocompatible Bolus. The PTPNR layer demonstrated skin adhesion (repetitive adhesion force of 8 kPa), antibacterial (> 95%) and anti-inflammatory properties. The PT layer was a water retention and mechanical barrier (compression modulus ≈550 kPa). This Janus biogel design integrates principles from biomedical and engineering fields, making it suitable for use as a Bolus material in treating superficial tumors.

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新型Janus生物凝胶丸的研制

在放射治疗中，丸剂是治疗浅表病变的关键。然而，弹丸材料的机械粘附和生物不匹配经常影响放射治疗的结果。本研究介绍了不对称Janus生物凝胶丸，其中一面具有粘附性，另一面具有最小粘附性。该生物凝胶是利用不同材料通过物理和化学相互作用的协同组合而制成的。上层主要由丙烯酰胺和海藻糖组成，简称PT；下层主要由丙烯酰胺、海藻糖、原儿茶酸、纳米粘土和白藜芦醇组成，简称PTPNR。进行了机械、生物学和放射学测试，以评估Janus贴片作为功能性和生物相容性丸。PTPNR层具有皮肤粘附性（重复粘附力为8 kPa）、抗菌（95%）和抗炎性能。PT层是一种保水和机械屏障（压缩模量≈550 kPa）。这种Janus生物凝胶设计结合了生物医学和工程领域的原理，使其适合用作治疗浅表肿瘤的丸状材料。

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来源期刊

Journal of biomedical materials research. Part B, Applied biomaterials 工程技术-材料科学：生物材料

CiteScore

7.50

自引率

2.90%

发文量

199

审稿时长

12 months

期刊介绍： Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.