Nazli Alizadeh, Yasir Q. Almajidi, Mastafa H. Al-Musawi, Mojtaba Abbasian, Hashim H. Al Zuaini, Marjan Ghorbani, Fatemeh Doustdar, Fatemeh Mortazavi Moghadam
{"title":"蜂胶注入电纺丝乌桕/PVP垫：一种生物活性和抗菌伤口敷料的新方法","authors":"Nazli Alizadeh, Yasir Q. Almajidi, Mastafa H. Al-Musawi, Mojtaba Abbasian, Hashim H. Al Zuaini, Marjan Ghorbani, Fatemeh Doustdar, Fatemeh Mortazavi Moghadam","doi":"10.1002/jbm.b.35625","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Electrospun mats with varying ratios of Eudragit L-100 (EU) to polyvinylpyrrolidone (PVP) were fabricated and characterized. Morphological analysis (FESEM), fiber diameter distribution, porosity measurements, degradability studies, and water vapor transmission rate (WVTR) assessments indicated that an EU/PVP ratio of 70:30 exhibited optimal properties. Propolis (PRO), known for its antimicrobial, antioxidant, and anti-inflammatory effects, was incorporated into the optimized mats at different weight percentages (5, 10, and 20 wt%). The inclusion of PRO resulted in increased fiber thickness and decreased porosity. PRO-loaded mats exhibited lower degradation rates and slightly enhanced tensile strength compared to the neat EU/PVP mats. A higher PRO content led to a reduction in WVTR, while radical scavenging activity increased to over 40%. Hemocompatibility and biocompatibility were confirmed through hemolysis tests, cell proliferation assays, cell attachment studies, and live/dead staining. Additionally, PRO-loaded mats exhibited antibacterial efficacy against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. The sustained release of PRO from the EU/PVP matrix further supports its potential as an effective wound dressing.</p>\n </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 8","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Propolis-Infused Electrospun Eudragit/PVP Mats: A Novel Approach for Bioactive and Antibacterial Wound Dressings\",\"authors\":\"Nazli Alizadeh, Yasir Q. Almajidi, Mastafa H. Al-Musawi, Mojtaba Abbasian, Hashim H. Al Zuaini, Marjan Ghorbani, Fatemeh Doustdar, Fatemeh Mortazavi Moghadam\",\"doi\":\"10.1002/jbm.b.35625\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Electrospun mats with varying ratios of Eudragit L-100 (EU) to polyvinylpyrrolidone (PVP) were fabricated and characterized. Morphological analysis (FESEM), fiber diameter distribution, porosity measurements, degradability studies, and water vapor transmission rate (WVTR) assessments indicated that an EU/PVP ratio of 70:30 exhibited optimal properties. Propolis (PRO), known for its antimicrobial, antioxidant, and anti-inflammatory effects, was incorporated into the optimized mats at different weight percentages (5, 10, and 20 wt%). The inclusion of PRO resulted in increased fiber thickness and decreased porosity. PRO-loaded mats exhibited lower degradation rates and slightly enhanced tensile strength compared to the neat EU/PVP mats. A higher PRO content led to a reduction in WVTR, while radical scavenging activity increased to over 40%. Hemocompatibility and biocompatibility were confirmed through hemolysis tests, cell proliferation assays, cell attachment studies, and live/dead staining. Additionally, PRO-loaded mats exhibited antibacterial efficacy against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. The sustained release of PRO from the EU/PVP matrix further supports its potential as an effective wound dressing.</p>\\n </div>\",\"PeriodicalId\":15269,\"journal\":{\"name\":\"Journal of biomedical materials research. Part B, Applied biomaterials\",\"volume\":\"113 8\",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of biomedical materials research. Part B, Applied biomaterials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35625\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomedical materials research. Part B, Applied biomaterials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35625","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Propolis-Infused Electrospun Eudragit/PVP Mats: A Novel Approach for Bioactive and Antibacterial Wound Dressings
Electrospun mats with varying ratios of Eudragit L-100 (EU) to polyvinylpyrrolidone (PVP) were fabricated and characterized. Morphological analysis (FESEM), fiber diameter distribution, porosity measurements, degradability studies, and water vapor transmission rate (WVTR) assessments indicated that an EU/PVP ratio of 70:30 exhibited optimal properties. Propolis (PRO), known for its antimicrobial, antioxidant, and anti-inflammatory effects, was incorporated into the optimized mats at different weight percentages (5, 10, and 20 wt%). The inclusion of PRO resulted in increased fiber thickness and decreased porosity. PRO-loaded mats exhibited lower degradation rates and slightly enhanced tensile strength compared to the neat EU/PVP mats. A higher PRO content led to a reduction in WVTR, while radical scavenging activity increased to over 40%. Hemocompatibility and biocompatibility were confirmed through hemolysis tests, cell proliferation assays, cell attachment studies, and live/dead staining. Additionally, PRO-loaded mats exhibited antibacterial efficacy against Escherichia coli and Staphylococcus aureus. The sustained release of PRO from the EU/PVP matrix further supports its potential as an effective wound dressing.
期刊介绍：
Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats:
• original research reports
• short research and development reports
• scientific reviews
• current concepts articles
• special reports
• editorials
Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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