Journal of Assisted Reproduction and Genetics最新文献

{"title":"Lost in translation: are doctors really answering patients' questions about in vitro fertilization?","authors":"Naveena R Daram, Malika L Day, Molly J Herr, Rose A Maxwell, Meghan C Ozcan","doi":"10.1007/s10815-025-03538-x","DOIUrl":"https://doi.org/10.1007/s10815-025-03538-x","url":null,"abstract":"<p><strong>Purpose: </strong>As social media grows as a health resource, IVF patients turn to Facebook and Reddit for guidance, while providers share educational content on TikTok and Instagram. This study examines the alignment between patient inquiries and provider content to identify gaps in digital fertility education.</p><p><strong>Methods: </strong>A cross-sectional qualitative analysis collected 50 top patient posts from five largest IVF Facebook and Reddit groups and 50 provider videos from Instagram and TikTok using popular IVF hashtags. Posts and videos were categorized into ten themes, engagement metrics analyzed, and provider content assessed for readability. Statistical analyses included chi-square tests for content distribution and independent t-tests and one-way ANOVA for readability differences (p < 0.05 considered significant).</p><p><strong>Results: </strong>Significant discrepancies were observed between patient inquiries and provider content. Patients most frequently inquired about medications, diagnostic testing, side effects, and emotional support-topics underrepresented in provider content. Providers disproportionately focused on procedural details (34.09% vs. 6.17%, p < 0.001). Readability analysis showed provider content exceeded the AMA-recommended 6th-grade reading level (range: 7.93-15.29). Despite misalignment, engagement with IVF-related content was high, with millions of views, likes, and comments across platforms.</p><p><strong>Conclusions: </strong>There is misalignment between what patients ask and what providers discuss on social media. Providers aiming content at patients should address patient priorities both online and in clinical practice while improving readability to enhance digital health literacy. Given the vast reach of social media, fertility specialists should consider establishing a presence to educate and engage with patients effectively.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The newly enacted Italian surrogacy law: Effects on reproductive tourism.","authors":"Susanna Marinelli, Giuseppe Gullo, Francesco Circosta, Simona Zaami, Robert Krysiak, Gianluca Montanari Vergallo","doi":"10.1007/s10815-025-03545-y","DOIUrl":"10.1007/s10815-025-03545-y","url":null,"abstract":"<p><strong>Purpose: </strong>In Italy, Law No. 169 of November 4, 2024, has come into force, criminalizing surrogacy even if it occurs abroad, provided at least one member of the requesting couple is an Italian citizen. This legislation stems from a firm conviction that surrogacy undermines the dignity of the surrogate mother and places the child thus born in a more precarious situation, compared to a child born to a mother who intends to raise them as her own. The authors have set out to outline a brief overview of surrogacy legal frameworks in Europe and in the USA, as a meaningful sample of Western countries largely sharing a common set of values. The ultimate purpose is to assess the potential effectiveness of this new extremely restrictive Italian law in dissuading Italian couples from seeking surrogacy abroad.</p><p><strong>Materials and methods: </strong>First-hand sources (national legislative bodies) have been delved into to shed a light on national norms governing surrogacy in major European countries and the USA. Databases De Jure and Onelegale, along with international scientific databases PubMed and Scopus, were drawn upon through the search terms/strings: surrogate motherhood; surrogacy; extraterritorial jurisdiction.</p><p><strong>Results: </strong>This law's consistency with European Court of Human Rights (ECtHR) jurisprudence and European Union law is dubious: it in fact appears to conflict with freedom of movement within the European Union and the child's best interests. Moreover, while it may hinder the pursuit of parenthood, its effectiveness in preventing reproductive tourism is still unclear.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-coding molecular determinants of polycystic ovary syndrome: A future treatment potential.","authors":"Prajna Bhandary, Prakash Patil","doi":"10.1007/s10815-025-03547-w","DOIUrl":"https://doi.org/10.1007/s10815-025-03547-w","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is an endocrine-gynaecological disorder characterized by hyperandrogenism and menstrual irregularity or ovarian cyst. The onset of PCOS involves a complex interplay among various factors such as genetics, epigenetics and environment. Despite significant efforts, currently there are no effective therapies to cure PCOS. Several non-coding RNA (ncRNA)-based therapeutic drugs are under investigation or in preclinical trials. Moreover, ncRNAs have been demonstrated to restore abnormal gene expression patterns, hormone secretion and signalling pathways, follicle development and ovulation in PCOS. Hence, they will undoubtedly aid in better understanding of molecular functions and therapeutics. So, this review examined many research on the differential expression of ncRNAs in PCOS and their potential use as biomarkers or therapeutic targets. Overall, we have summarised the recent advancements in the use of ncRNAs in targeted treatments, with a focus on their underlying potential and future prospects of ncRNA therapy in PCOS.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of clinical exome sequencing in sperm donor screening in China.","authors":"Jie Huang, Man Yu, Jie Yang, Wenjing Xue, Zhou Zhang, Juanzi Shi, Wenhao Shi","doi":"10.1007/s10815-025-03540-3","DOIUrl":"https://doi.org/10.1007/s10815-025-03540-3","url":null,"abstract":"<p><strong>Purpose: </strong>In China, genetic testing is conducted by only a small proportion of sperm banks. Traditional sperm donor screening primarily relies on family history to exclude individuals with known genetic diseases. However, this method does not fully address the genetic risks associated with recessive and late-onset dominant disorders. This study aims to conduct genetic testing for sperm donors using high-coverage clinical exome sequencing (CES) to identify disease-causing mutations in voluntarily submitted blood samples.</p><p><strong>Methods: </strong>Peripheral blood samples from sperm donors were collected for clinical exome sequencing (CES), which targeted the coding exons of approximately 5595 clinically relevant disease-causing genes.</p><p><strong>Results: </strong>Among the 391 donors, 372 (95.14%) were identified as carriers of at least one pathogenic or likely pathogenic variant, including those related to autosomal recessive, digenic recessive, and complex inheritance patterns. The carrier rate for autosomal dominant and X-linked conditions was 4.86% (19/391). On average, each donor carried 3.53 recessive genetic defects. The most frequent variants were found in UGT1 A, FLG, and GJB2. Six donors with high-frequency SMN1 exon 7-8 deletions were excluded. Ultimately, 45 donors (11.51%) were rejected, resulting in a qualification rate of 88.49%.</p><p><strong>Conclusions: </strong>Clinical exome sequencing (CES) of sperm donors identified carriers of genetic conditions and excluded those with a history of dominant genetic disorders. Additionally, joint donor-recipient matching for recessive gene carriers can reduce the risk of congenital defects in offspring conceived through assisted reproduction, ensuring genetic compatibility and preventing unintended transmission of genetic disorders.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burnout: a silent saboteur in in vitro fertilization laboratories.","authors":"Murat Basar, Tuba Duzcu","doi":"10.1007/s10815-025-03537-y","DOIUrl":"https://doi.org/10.1007/s10815-025-03537-y","url":null,"abstract":"<p><p>Embryologists operate in highly demanding environments where burnout is an increasingly recognized occupational hazard. This review aims to delineate the types, causes, and consequences of burnout among embryologists, compare burnout prevalence across medical laboratory specialties, and propose evidence-based strategies for mitigation, emphasizing its impact on patient outcomes and laboratory performance. A comprehensive literature review synthesized findings from cross-sectional surveys, meta-analyses, systematic reviews, and consensus guidelines related to burnout in healthcare and laboratory settings. Special focus was given to embryology-specific data, including occupational stressors, emotional labor, and workload metrics. Comparative analyses were performed to contextualize embryologist burnout within broader laboratory medicine. Embryologists report the highest emotional burnout levels among assisted reproductive technology (ART) professionals. Contributing factors include excessive workloads, irregular hours, outcome visibility, ethical dilemmas, limited career progression, and poor interdepartmental communication. Burnout negatively affects cognitive performance, psychomotor precision, protocol adherence, and communication, directly impacting IVF outcomes. High-burnout laboratories show increased witnessing discrepancies and reduced patient satisfaction. Evidence suggests that burnout is not only a personnel issue but also a critical quality and safety concern. Burnout in IVF laboratories is a systemic issue that compromises embryologist well-being and ART success. Multilevel interventions-spanning organizational policies, regulatory frameworks, leadership development, and technological innovations-are essential. Integrating burnout assessment into routine quality assurance and regulatory monitoring can enhance staff sustainability and patient care outcomes in reproductive medicine.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel small droplets freezing method for human sperm cryopreservation: maximizing utilization of limited samples.","authors":"Yael Harir, Rona Halevy Amiran, Miriam Almagor, Sheila Fieldust, Zeev Shoham, Yuval Or","doi":"10.1007/s10815-025-03532-3","DOIUrl":"10.1007/s10815-025-03532-3","url":null,"abstract":"<p><strong>Purpose: </strong>The study aims to evaluate and compare sperm progressive motility before and after cryopreservation using the conventional slow freezing technique versus a novel small droplets freezing method. This research seeks to determine the optimal freezing technique, particularly for preserving unique and irreplaceable sperm samples.</p><p><strong>Methods: </strong>Seventy-five sperm samples were divided and cryopreserved using two techniques: (1) the classic slow freezing method and (2) the small droplets freezing method. After thawing, sperm progressive motility was assessed and compared between the two methods.</p><p><strong>Results: </strong>No significant difference in sperm progressive motility was observed between the two techniques. The mean post-thaw progressive motility was 22.9% for the classical method and 23.64% for the small droplets method (p = 0.74), indicating comparable outcomes.</p><p><strong>Conclusion: </strong>Cryopreservation in small droplets maintains sperm progressive motility similarly to conventional slow freezing. This technique allows for more efficient utilization of limited sperm samples, making it particularly valuable for posthumous sperm retrieval, fertility preservation in oncological patients, and cases where sperm availability is extremely limited.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-omics reveals temporal translational recovery landscapes and cryodamage repair mechanisms in vitrified mouse oocytes.","authors":"Shaohong Zhuang, Xiaoting Diao, Rui Xiang, Jiana Huang, Jiahui Pang, Na Lu, Qiqi Liang, Xinyi Pan, Rang Liu, Cong Fang, Xiaoyan Liang, Wenlin Peng, Haitao Zeng","doi":"10.1007/s10815-025-03482-w","DOIUrl":"https://doi.org/10.1007/s10815-025-03482-w","url":null,"abstract":"<p><strong>Purpose: </strong>The efficacy of oocyte cryopreservation still requires enhancement. Current understanding of cryodamage is largely limited to the organelle level, and the impact of freezing on oocyte gene expression remains unclear.</p><p><strong>Methods: </strong>In this study, we employed an innovative dual-omics approach to assess the transcriptional and translational profiles of mouse metaphase II (MII) oocytes during the initial 4 h post-thaw.</p><p><strong>Results: </strong>Our mapping of the translational recovery in vitrified mouse oocytes post-thaw revealed a critical 2-h window that is optimal for recovery. We confirmed the mitochondrial damage associated with vitrification and identified the activation of autophagy and proteasomal degradation during this period. Additionally, our analysis indicates that vitrified oocytes have another repair response to counteract cryoinjury, involving spindle remodeling and membrane recycling.</p><p><strong>Conclusions: </strong>These findings can guide future efforts to improve oocyte vitrification outcomes by improving repair processes and not focusing solely on the damage processes.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An analysis of freeze-all cycles to investigate the association between elevated progesterone on day of trigger and oocyte quality.","authors":"Achraf Benammar, Catherine Racowsky, Katharine Correia, Maria-Teresa Hadchity, Marine Poulain, Paul Pirtea, Jean-Marc Ayoubi","doi":"10.1007/s10815-025-03528-z","DOIUrl":"https://doi.org/10.1007/s10815-025-03528-z","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether a premature rise in progesterone at the end of the follicular phase is adversely associated with oocyte quality in IVF cycles.</p><p><strong>Methods: </strong>A retrospective cohort study including patients less than or equal to 40 years of age undergoing their first IVF/ICSI cycle between January 2017 and December 2021 with freeze-all involving D5 or D6 blastocysts. Main Outcome Measure(s) Cumulative live birth rate (cLBR) and cumulative sustained implantation rate (cSIR).</p><p><strong>Result: </strong>(s) A total of 1,373 IVF/ICSI cycles were included and categorized into progesterone tertiles (T1: 0.10-0.96 ng/ml; T2: 0.97-1.63 ng/ml; T3: 1.64-9.62 ng/ml). The cLBRs for T1, T2, and T3 were 54.0%, 56.6%, and 52.9%, respectively, and the cSIRs were 54.4%, 56.8%, and 53.3%, respectively. After adjustment for age, peak estradiol, and total dose of gonadotropins used, the risk of cLBR was statistically significantly increased for women in T2 (RR 1.19, 95% CI 1.06-1.33) and T3 (RR 1.14, 95% CI 1.01-1.28) compared with T1. Similar results were obtained for cSIR. For cycles with 5-10 oocytes, a statistically significant positive association was observed between T3 progesterone:oocyte ratio for both cLBR (RR 1.78, 95% CI 1.22-2.60) and cSIR (RR 1.80, 95% CI 1.24-2.62) compared with T1 after adjusting for oocyte number, while no such association was observed for cycles with >10 oocytes retrieved (cLBR: RR 0.95, 95% CI 0.84-0.95; cSIR: RR 0.95, 95% CI 0.83-1.08).</p><p><strong>Conclusion: </strong>Our findings do not support an adverse association between a premature rise in progesterone and oocyte quality. In normal responders, this rise may be beneficial.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of FUT8 impairs embryonic development by reducing cAMP production in granulosa cells.","authors":"Tiantong Wang, Zhiwei Zhang, Changduo Qu, Yanbin Shi, Shaobin Chen, Wenzhe Li, Ming Li","doi":"10.1007/s10815-025-03536-z","DOIUrl":"https://doi.org/10.1007/s10815-025-03536-z","url":null,"abstract":"<p><strong>Purpose: </strong>In cases of impaired fertility, the quality of oocytes and their subsequent embryonic development following fertilization are critical concerns in clinical practice. Core fucosylation, catalyzed by fucosyltransferase 8 (FUT8), is a common N-glycosylation modification that plays a key role in cell proliferation and signal transduction. This study examines the role of core fucosylation in follicular regulation during oocyte development.</p><p><strong>Methods: </strong>Patients were categorized into two groups based on their embryo formation rates. Core fucosylation levels, catalyzed by FUT8, were assessed in serum and follicular fluid (containing granulosa cells). To investigate the molecular effects of FUT8 on oocyte quality, FUT8-knockdown human granulosa cells (KGN-KD), and ovaries from Fut8 gene knockout (Fut8^-/-) mice were analyzed.</p><p><strong>Results: </strong>Core fucosylation levels were lower in patients with reduced blastocyst formation rates. FUT8 depletion led to decreased cAMP production following follicle-stimulating hormone (FSH) stimulation in both KGN-KD and the ovaries of Fut8^-/- mice. Additionally, the expression of FIGLA (folliculogenesis-specific basic helix-loop-helix transcription factor) and other genes associated with embryonic development was downregulated in the ovaries of Fut8^-/- mice. Oocytes from Fut8^-/- mice exhibited abnormal zona pellucida formation and impaired embryonic development.</p><p><strong>Conclusion: </strong>These findings indicate that FUT8 ablation may disrupt embryonic development post-fertilization by reducing FSH receptor (FSHR) signaling and downregulating FIGLA expression. The results suggest that core fucosylation is essential for female reproduction and oocyte quality.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Every second counts: the association of embryo transfer duration with live birth following 2267 single, euploid, frozen embryo transfer.","authors":"Blake Vessa, Devika Sachdev, Leah Roberts, Kara Scarpetti, Christine Whitehead, Maria Costantini, Paul Bergh, Marie Werner, Kassie Bollig","doi":"10.1007/s10815-025-03520-7","DOIUrl":"https://doi.org/10.1007/s10815-025-03520-7","url":null,"abstract":"<p><strong>Purpose: </strong>To identify the impact of the duration of the embryo transfer procedure on pregnancy outcomes.</p><p><strong>Methods: </strong>This was a retrospective cohort study at a single center including single euploid frozen embryo transfers from April to December 2022. Embryo transfer time was defined as the total time (seconds) from when the embryologist handed the catheter with the loaded embryo to the physician, to the release of the embryo into the uterus. Time measurements were divided into quartiles: (1) 4-27 s, (2) 28-38 s, (3) 39-54 s, and (4) 55-1028 s. The primary outcome was the probability of live birth per transfer. Secondary outcomes included biochemical pregnancy, clinical pregnancy, and pregnancy loss.</p><p><strong>Results: </strong>A total of 2267 frozen embryo transfer cycles were included in the analysis. The overall live birth rate was 59.8% (1356/2267). Compared to the fastest time (1st quartile), the probability of live birth was significantly decreased for couples with the longest transfer times (4th quartile) after adjusting for possible confounding variables (aOR, 0.76; 95% CI 0.58-0.99; p = 0.046). When patients with more difficult embryo transfers, that as a result may be inherently longer, were excluded, the results were the same as the primary model. However, when data was analyzed using only first transfers, compared to the shortest transfer time quartile (1st), there was a significant decreased probability of live birth in the 3rd quartile (OR 0.63, 95% CI 0.41-0.94, p = 0.025), but no significant differences in the 2nd or 4th quartile groups (p = 0.213, p = 0.800). There were no differences in the probability of biochemical pregnancy, clinical pregnancy, or pregnancy loss in the fully adjusted model.</p><p><strong>Conclusion: </strong>The longest embryo transfer times are associated with significantly decreased probability of live birth.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}