Journal of Assisted Reproduction and Genetics最新文献

{"title":"Potential unmet fertility needs among men cancer survivors: exploratory evidence from the National Survey of Family Growth.","authors":"Katherine Tierney, Kelsey Sullivan","doi":"10.1007/s10815-025-03700-5","DOIUrl":"https://doi.org/10.1007/s10815-025-03700-5","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate (1) sociodemographic variation in fertility care-seeking among men with a history of cancer at or before age 44, (2) whether sociodemographic inequalities among men with a history of cancer differ from men without a history of cancer, and (3) whether care-seeking differed among women and men with a history of cancer.</p><p><strong>Methods: </strong>This study uses five cycles of National Survey of Family Growth (NSFG), a nationally representative survey of women and men in the USA. Multivariable logistic regression with and without interaction terms were employed.</p><p><strong>Results: </strong>Among men young cancer survivors (YCS), non-Hispanic white men were less likely to ever-seek fertility care than YCS men of color (odds ratio = 0.28, p < 0.10). Additionally, among YCS men, those with less than bachelor's degree had lower odds of ever-seeking fertility care relative to those with a bachelor's or higher (OR = 0.25, p < 0.10). Analyses with interaction terms showed that the associations between ever-seeking care and race/ethnicity were significantly different among men YCS than men without a history of cancer (OR = 0.20, p < 0.05), while associations with educational attainment did not differ significantly between these groups. Finally, the results showed women YCS had higher odds of ever-seeking fertility care than men YCS (OR = 3.20, p < 0.01).</p><p><strong>Conclusions: </strong>Fertility care-seeking among men YCS differs by race/ethnicity from the associations observed among men without a history of cancer. Meanwhile, associations between care-seeking and education and sex were similar to associations observed in populations without a history of cancer. Thus, there may be unmet need for fertility-care among men YCS.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of chemical pollution and warming on male fertility: a narrative review by the Special Interest Group \"Environment and Fertility\" of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR).","authors":"Giuseppe Defeudis, Cristina de Angelis, Rossella Mazzilli, Federica Barbagallo, Claudia Leanza, Iva Sabovic, Rosita A Condorelli, Rocco Rago, Daniele Gianfrilli, Rosario Pivonello, Andrea Di Nisio, Paola Anserini, Carlo Foresta","doi":"10.1007/s10815-025-03678-0","DOIUrl":"https://doi.org/10.1007/s10815-025-03678-0","url":null,"abstract":"<p><p>Environmental changes are a growing global concern, and their impact on reproductive health remains incompletely understood. In this narrative review, conducted on behalf of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR), we examined the impact of the environment on male fertility, considering endocrine-disrupting chemicals (EDCs), air pollution, and global warming, with the aim of identifying strategies to improve reproductive outcomes. Scientific literature demonstrates that all these aspects may contribute to a decline in reproductive health, impairing sperm count, motility, and morphology as well as reducing testicular hormonal function. Future research should focus on the role of environmental factors in male hypogonadism, impaired spermatogenesis, genital abnormalities, and transgenerational effects.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zona-free blastocyst transfers have significantly lower pregnancy and live birth rates compared to zona-intact blastocysts.","authors":"Ying Ying, Michelle Matthews, Rebecca Usadi, Kathryn Goldrick, Ashley Eskew, Tasha L Gill, Bradley S Hurst","doi":"10.1007/s10815-025-03693-1","DOIUrl":"https://doi.org/10.1007/s10815-025-03693-1","url":null,"abstract":"<p><strong>Purpose: </strong>To assess whether zona-free blastocysts are associated with reduced pregnancy and live birth rates in single frozen embryo transfers (FETs), given their increasing use following trophectoderm biopsy for preimplantation genetic testing (PGT).</p><p><strong>Materials and methods: </strong>This retrospective case-control study analyzed FET cycles performed at a single center between January 2015 and December 2023. Inclusion criteria were single day 5 or 6 blastocyst FETs; cycles involving two or more embryos were excluded. A total of 353 FETs with zona-free blastocysts were matched 1:1 with zona-intact blastocyst transfers based on PGT status, patient age at oocyte retrieval, and embryo quality. Clinical outcomes included positive hCG, clinical pregnancy, biochemical pregnancy loss, clinical pregnancy loss, and live birth rates. Statistical analyses were conducted using appropriate parametric or non-parametric tests.</p><p><strong>Results: </strong>2,810 single blastocyst FETs were performed, and 353 (12.6%) utilized zona-free blastocysts. Baseline characteristics, including patient age, BMI, endometrial thickness, and infertility diagnosis, were comparable between groups. Transfers involving zona-free blastocysts were associated with significantly lower rates of positive hCG, clinical pregnancy, and live birth (all p < 0.0001). While biochemical and clinical pregnancy loss rates did not differ significantly, the overall pregnancy loss rate was significantly higher in the zona-free group compared to zona-intact (p = 0.04).</p><p><strong>Conclusions: </strong>Single blastocyst FETs involving zona-free blastocysts are associated with significantly lower pregnancy and live birth rates compared to zona-intact blastocysts.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lycopene improves the developmental competence of vitrified-thawed oocytes by reestablishing redox balance and modulating Rock1 expression.","authors":"Songmao Li, Qing Zhang, Li Zhang, Yongjian Ma, Feng Chen, Di Sun, Baicai Yang, Yanquan Li, Qianhui Hu, Fanghao Guo, Meiling Zhang, Wen Li","doi":"10.1007/s10815-025-03640-0","DOIUrl":"https://doi.org/10.1007/s10815-025-03640-0","url":null,"abstract":"<p><strong>Purpose: </strong>Oocyte vitrification is a critical technique for female fertility preservation; however, it is often accompanied by cryodamage that compromises subsequent embryo development. Moreover, limited research has assessed the long-term effects on offspring derived from vitrified oocytes. While antioxidants are frequently used to mitigate vitrification-induced oxidative stress and have been shown to enhance embryo development, their impact on implantation and offspring outcomes remains underexplored. Lycopene (LYC), a potent natural antioxidant, has not yet been evaluated in the context of oocyte vitrification.</p><p><strong>Methods: </strong>Oocytes were collected from 4-week-old C57/BL6J female mice. Fresh oocytes served as the negative control (n = 393). Vitrified-thawed oocytes were cultured in post-warming, IVF, and embryo culture media supplemented with 0 µM (positive control, n = 479), 0.05 µM (n = 485), 0.1 µM (n = 499), or 0.2 µM (n = 461) lycopene. Blastocysts from the fresh, vitrified, and LYC-0.1µM groups were transferred into the uterine horns of 3.5-dpc pseudopregnant 8-week-old ICR female mice to assess in vivo development.</p><p><strong>Results: </strong>Supplementation with 0.1 µM lycopene significantly improved the blastocyst formation rate in vitrified oocytes (75.56 ± 8.69% vs. 66.53 ± 6.94%, P = 0.029). Lycopene treatment elevated intracellular glutathione (GSH) levels (P < 0.001) and reduced reactive oxygen species (ROS) levels (P = 0.014). Notably, 0.1 µM lycopene modulated Rock1 expression during early embryogenesis, especially at the 4-cell stage, suggesting a potential role in developmental regulation. Despite improved preimplantation development, live birth rates following embryo transfer were similar between vitrified groups with or without lycopene, and both remained significantly lower than the fresh group (P = 0.008). None of the offspring had any apparent birth defect. No significant differences were observed among offspring in birth weight, growth trajectory, major organ morphology, gonadosomatic indices, or follicles counting among offspring.</p><p><strong>Conclusions: </strong>Lycopene exerts a protective effect against vitrification-induced oxidative stress by restoring redox homeostasis within oocytes and modulating Rock1 expression during early embryo development. Importantly, lycopene treatment did not compromise offspring health, supporting its potential as a safe adjunct to improve vitrification outcomes.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single euploid embryo transfer outcomes following cancer and systemic chemotherapy.","authors":"Johanna Suskin, Keri Bergin, Morgan Baird, Joseph Lee, Alan B Copperman, Erkan Buyuk, Jovana Lekovich","doi":"10.1007/s10815-025-03686-0","DOIUrl":"https://doi.org/10.1007/s10815-025-03686-0","url":null,"abstract":"<p><strong>Purpose: </strong>Systemic chemotherapy may impair future reproduction due to its gonadotoxic effects. There are limited data on pregnancy outcomes in patients with a history of chemotherapy who undergo single euploid embryo transfer (SEET).</p><p><strong>Materials and methods: </strong>This retrospective cohort study included patients with prior chemotherapy who underwent SEET from 2011 to 2023. Cycles were matched 1:3 with controls by oocyte age, age at SEET, BMI, and year. Wilcoxon rank, chi-square, and adjusted logistic regression were used for analysis. A sub-analysis was performed to compare patients who had SEET using oocytes retrieved pre- and post-chemotherapy.</p><p><strong>Results: </strong>Fifty-five cycles from 32 patients with prior chemotherapy were matched to 165 control cycles. In the chemotherapy group, 23 cycles (41.8%) used embryos derived from oocytes pre-chemotherapy, while 32 cycles (58.2%) used embryos derived from oocytes post-chemotherapy. Endometrial thickness was significantly lower with prior chemotherapy vs. controls (8 mm vs 9 mm, respectively; p = 0.02). Ongoing pregnancy/live birth rate was similar in patients with prior chemotherapy and controls (56.4% vs. 57.0%, p = 0.94). Adjusted analysis confirmed the findings (aOR 1.5, CI 0.79-2.8, p = 0.21). Pregnancy, clinical pregnancy, and loss rates were similar. The subgroup analysis showed no statistical difference in outcomes in patients who used pre-chemotherapy vs. post-chemotherapy oocytes. However, a trend towards poorer outcomes in patients who used post-chemotherapy oocytes was observed.</p><p><strong>Conclusions: </strong>Outcomes after SEET in patients with prior chemotherapy are comparable to controls. A possible trend toward reduced success using post-chemotherapy oocytes warrants further investigation. Understanding the potential mechanisms by which chemotherapy may affect future fertility is important for survivorship care.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sperm selection for assisted reproductive technology: do we have a winner?","authors":"Youjiang Li, Hao Wang, Xue Sun, Qiaodan Li, Jian Xu","doi":"10.1007/s10815-025-03684-2","DOIUrl":"https://doi.org/10.1007/s10815-025-03684-2","url":null,"abstract":"<p><p>Assisted reproductive technology (ART) has emerged as a pivotal solution for human infertility, with intracytoplasmic sperm injection (ICSI) being widely adopted. The quality of sperm is critical to the outcomes of ART, and the selection of optimal sperm is essential for enhancing embryo quality. In recent years, researchers have developed various advanced sperm selection methods that simulate the natural sperm selection process occurring in the female reproductive tract. Although many studies have been conducted to identify the selection technique, many doubts and disagreements still remain. In this review, we will examine the characteristics, advantages, and limitations of both traditional and advanced sperm selection methods, evaluate their impact on sperm quality and functional parameters, as well as ART outcomes for infertile couples, and provide evidence-based recommendations for embryologists to optimize sperm selection strategies.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) in a Japanese population: experience from seven clinics.","authors":"Takeshi Iwasa, Yuri Yamamoto, Hiroki Noguchi, Yuka Miyazaki, Akari Obashi, Tatsuya Nakano, Noritaka Fukunaga, Hiroyuki Watanabe, Sho Takeda, Hirofumi Morita, Ryoma Tsuchiya, Shigetoshi Mizumoto, Yozo Nagao, Takeshi Sugimoto, Shiori Ishida, Kohyu Furuhashi, Daniela N Bakalova, Ianae Ichikawa Ceschin, Aisaku Fukuda, Yoshiharu Nakaoka, Yoshimasa Asada, Keiich Kato, Takeshi Kuramoto, Satoshi Kawachiya, Masahide Shiotani","doi":"10.1007/s10815-025-03670-8","DOIUrl":"https://doi.org/10.1007/s10815-025-03670-8","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to determine the feasibility of implementing non-invasive PGT-A (niPGT-A) in clinical practice. Informativity and concordance rates between three sample types (embryonic cell-free DNA [cfDNA] present in spent blastocyst medium [SBM], trophectoderm [TE] biopsy, and whole blastocyst [WB]) from the same embryo were evaluated.</p><p><strong>Methods: </strong>This was a prospective, multicenter study conducted between February 2022 and November 2022 at seven Japanese IVF centres. 212 blastocysts were donated for research. The cfDNA released into the SBM was analysed, and the results were compared against the corresponding TE biopsy and WB sample.</p><p><strong>Results: </strong>Overall informativity rates for SBM, TE, and WB were 81.6% (173/212), 98.6% (209/212), and 98.6% (209/212), respectively. There was no difference between TE and WB; however, SBM was significantly different to both (p < 0.001). The informativity rate in SBM samples significantly varied among the seven centres, ranging between 72.7 and 97.1% (p = 0.041). Ploidy concordance (SBM-TE) also varied across the centres, ranging between 68.2 and 90.9%; however, this did not reach statistical significance (p = 0.63). Ploidy concordance rates in SBM-TE, SBM-WB, and TE-WB were 77.4% (130/168), 77.4% (130/168), and 90.5% (152/168), respectively. There was no statistical difference for SBM-TE and SBM-WB, but both were statistically different to TE-WB (p = 0.0054).</p><p><strong>Conclusion: </strong>We have shown results that are consistent with the existing literature, indicating the feasibility of applying the niPGT-A protocol described here, and thus using the SBM result to establish a priority for embryo transfer.</p><p><strong>Trial registration information: </strong>The study was approved by Tokushima University Hospital Life Science and Medical Research Ethics Review Committee (Permission number: 4057).</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of blastocyst quality on neonatal outcomes in frozen embryo transfer cycles: a cohort study.","authors":"Tingting He, Xia Xue, Juanzi Shi, Yuhua Shi","doi":"10.1007/s10815-025-03682-4","DOIUrl":"https://doi.org/10.1007/s10815-025-03682-4","url":null,"abstract":"<p><strong>Purpose: </strong>To study the effect of blastocyst quality on neonatal outcomes in frozen embryo transfer (FET) cycles.</p><p><strong>Methods: </strong>This retrospective study included a total of 7,308 women who underwent single blastocyst transfer during FET cycles and achieved singleton live births from January 2015 to June 2022. Women were categorized into two groups: poor-quality blastocyst (PQB; n = 2540) and good-quality blastocyst (GQB; n = 4768). The primary outcomes were the rates of cesarean section and male sex. The second outcomes were very small for gestational age (VSGA), small for gestational age (SGA), large for gestational age (LGA), very large for gestational age (VLGA), very preterm birth (VPTB), preterm birth (PTB), high birth weight (HBW), very low birth weight (VLBW), low birth weight (LBW), gestational age, and birth weight.</p><p><strong>Results: </strong>Compared with the PQB group, the GQB group was associated with a decreased cesarean section rate (adjusted odds ratio [aOR] 0.88, 95% confidence interval [CI], 0.77-0.99; P = 0.034) and an increased likelihood of having a male child (aOR 1.27, 95%CI, 1.14-1.40; P < 0.001). However, no differences were observed in other neonatal outcomes, including VSGA, SGA, LGA, VLGA, VPTB, PTB, HBW, VLBW, LBW, gestational age, and birth weight.</p><p><strong>Conclusions: </strong>GQB is associated with a decreased cesarean section rate and an increased likelihood of having a male child. However, it has no effect on other neonatal outcomes. Therefore, both clinicians and patients can be reassured about the neonatal outcomes of singleton live births resulting from PQB in FET cycles.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overexpressed miR-135b in the ovaries of PCOS promotes granulosa cell proliferation by inhibiting Hippo signaling pathway.","authors":"Shimin Ren, Liyang Chen, Ni Xiao, Xueying Huang, Xian Wang, Yang Li, Bing Zhang, Wenjuan Wang, Xin Huang","doi":"10.1007/s10815-025-03687-z","DOIUrl":"https://doi.org/10.1007/s10815-025-03687-z","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder, characterized by ovarian structural abnormalities that lead to ovulatory dysfunction. The Hippo signaling pathway is crucial in regulating ovarian enlargement and cortical thickening, which are hallmarks of PCOS, although the regulatory mechanisms remain unclear.</p><p><strong>Methods: </strong>We assessed the expression of miR-135b and its target gene LATS2 (large tumor suppressor 2) in granulosa cells from both PCOS and normal ovaries using quantitative PCR. Dual-luciferase assays confirmed their direct interaction. The expression and localization of YAP (yes-associated protein), a key effector of the Hippo pathway, were examined through immunofluorescence in granulosa cells (GCs) from both groups. Additionally, the impact of miR-135b overexpression or inhibition on Hippo pathway genes was investigated in the KGN granulosa cell line, with changes in cell proliferation and apoptosis analyzed by cell proliferation assay and flow cytometry.</p><p><strong>Results: </strong>MiR-135b was significantly upregulated (9.15-fold) in PCOS granulosa cells and targeted LATS2, a critical Hippo pathway regulator. Dual-luciferase assays confirmed the miR-135b binding site in the 3'-UTR of LATS2. Mechanistically, high miR-135b expression reduced LATS2 levels, impairing YAP phosphorylation, promoting nuclear translocation of unphosphorylated YAP, and driving excessive granulosa cell proliferation.</p><p><strong>Conclusion: </strong>Our findings suggest that miR-135b overexpression in PCOS ovaries contributes to abnormal granulosa cell proliferation by inhibiting the Hippo pathway. This study enhances our understanding of ovarian abnormalities in PCOS and identifies miR-135b as a potential biomarker and therapeutic target for the disorder.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of psychological burden and quality of life in couples undergoing infertility treatments.","authors":"Munawwer, Kali Shree Priya, Durga Gedela Rao, Krishna Mantravadi","doi":"10.1007/s10815-025-03674-4","DOIUrl":"https://doi.org/10.1007/s10815-025-03674-4","url":null,"abstract":"<p><strong>Purpose: </strong>There is limited understanding of how infertility affects the quality of life among individuals in Indian population. The current investigation explored the psychological consequences of infertility in the Indian socio-cultural setting.</p><p><strong>Methods: </strong>Couples with fertility issues who visited infertility clinics between May 2023 and January 2024 were included based on specific criteria. Those who gave informed consent completed the FertiQoL and HADS questionnaires. Scores were summarized using mean and standard deviation. Pearson's correlation coefficient was used to examine relationships between quality of life, anxiety, and depression. The statistical significance of these correlations was assessed using the t-test.</p><p><strong>Results: </strong>A total of 250 participants were recruited; 200 completed the FertiQoL questionnaire and 197 completed the HADS. Of the FertiQoL respondents, 101 were male and 99 female. The mean FertiQoL score was 60.37 ± 14.42 (range: 19.12-92.65). The mean HADS-A score was 9.17 ± 3.63, and HADS-D was 6.84 ± 3.87. Among females, HADS-A and HADS-D scores were 9.22 ± 3.67 and 6.83 ± 3.89, respectively; among males, 9.17 ± 3.67 and 6.76 ± 3.88. Pearson correlation showed a significant negative association between FertiQoL and anxiety (r = -0.34, p < 0.00003) and depression (r = -0.30, p < 0.00001), indicating lower quality of life with higher anxiety and depression.</p><p><strong>Conclusions: </strong>Infertile couples reported a moderate quality of life, with anxiety at borderline levels and depression nearing borderline. Psychological counselling and increased social awareness are essential to reduce distress and enhance overall well-being.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}