The impact of chemical pollution and warming on male fertility: a narrative review by the Special Interest Group "Environment and Fertility" of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR).

IF 2.7 3区医学 Q2 GENETICS & HEREDITY

Journal of Assisted Reproduction and Genetics Pub Date : 2025-10-09 DOI:10.1007/s10815-025-03678-0

Giuseppe Defeudis, Cristina de Angelis, Rossella Mazzilli, Federica Barbagallo, Claudia Leanza, Iva Sabovic, Rosita A Condorelli, Rocco Rago, Daniele Gianfrilli, Rosario Pivonello, Andrea Di Nisio, Paola Anserini, Carlo Foresta

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引用次数: 0

Abstract

Environmental changes are a growing global concern, and their impact on reproductive health remains incompletely understood. In this narrative review, conducted on behalf of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR), we examined the impact of the environment on male fertility, considering endocrine-disrupting chemicals (EDCs), air pollution, and global warming, with the aim of identifying strategies to improve reproductive outcomes. Scientific literature demonstrates that all these aspects may contribute to a decline in reproductive health, impairing sperm count, motility, and morphology as well as reducing testicular hormonal function. Future research should focus on the role of environmental factors in male hypogonadism, impaired spermatogenesis, genital abnormalities, and transgenerational effects.

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化学污染和变暖对男性生育能力的影响：意大利生育、不育和生殖医学学会（sives - mr）“环境与生育”特别兴趣小组的叙述性回顾。

环境变化是一个日益引起全球关注的问题，其对生殖健康的影响仍未完全了解。在代表意大利生育、不育和生殖医学学会（sives - mr）进行的这篇叙述性综述中，我们研究了环境对男性生育能力的影响，考虑了内分泌干扰化学物质（EDCs）、空气污染和全球变暖，目的是确定改善生殖结果的策略。科学文献表明，所有这些方面都可能导致生殖健康下降，精子数量、活力和形态受损，以及睾丸激素功能降低。未来的研究应关注环境因素在男性性腺功能减退、精子发生障碍、生殖器异常和跨代影响中的作用。

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.