Journal of Assisted Reproduction and Genetics最新文献

{"title":"FertilitY Predictor-a machine learning-based web tool for the prediction of assisted reproduction outcomes in men with Y chromosome microdeletions.","authors":"Stacy Colaco, Priyanka Narad, Ajit Kumar Singh, Payal Gupta, Alakto Choudhury, Abhishek Sengupta, Deepak Modi","doi":"10.1007/s10815-024-03338-9","DOIUrl":"10.1007/s10815-024-03338-9","url":null,"abstract":"<p><strong>Purpose: </strong>Y chromosome microdeletions (YCMD) are a common cause of azoospermia and oligozoospermia in men. Herein, we developed a machine learning-based web tool to predict sperm retrieval rates and success rates of assisted reproduction (ART) in men with YCMD.</p><p><strong>Methods: </strong>Data on ART outcomes of men with YCMD who underwent ART were extracted from published studies by performing a systematic review. This data was used to develop a web-based predictive algorithm using machine learning.</p><p><strong>Results: </strong>FertilitY Predictor classifies the type of YCMD into AZFa, AZFb, AZFc, their combinations, and gr/gr deletions based on the genetic markers as input. Further, it predicts the probability of sperm retrieval, fertilization rate, clinical pregnancy rate, and live birth rate based on the type of YCMD. Validation studies demonstrated its high accuracy and predictability for sperm retrieval, clinical pregnancy rates, and live birth rates. The tool predicts that men with deletions have a chance of sperm retrieval that varies with type of deletions, the clinical pregnancy rates and live birth rates are lower in men with AZF deletions. A trial version of the tool is available at http://fertilitypredictor.sbdaresearch.in .</p><p><strong>Conclusions: </strong>FertilitY Predictor allows users to classify AZFa, AZFb, AZFc, and gr/gr deletions and also predict the outcomes of ART based on the type of deletions.</p><p><strong>Trial registration: </strong>PROSPERO (CRD42022311738).</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"473-481"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of SARS-CoV-2 on the male reproductive tract: insights from semen analysis and cryopreservation.","authors":"Silvia Giugliano, Alessandro M Mozzarelli, Annalisa Navarra, Gabriele De Simone, Maria Rescigno, Paolo E Levi-Setti, Elena Albani","doi":"10.1007/s10815-024-03321-4","DOIUrl":"10.1007/s10815-024-03321-4","url":null,"abstract":"<p><strong>Purpose: </strong>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus behind the COVID-19 pandemic, affects multiple organs, including the male reproductive system. While viral infections can harm male fertility through cytokine storms, the effects of SARS-CoV-2 on fertility are still unclear. Thus, this study aimed to examine the persistence of viral RNA and inflammatory responses in semen following SARS-CoV-2 infection and the safety of conventional freezing and vitrification techniques.</p><p><strong>Methods: </strong>Semen samples from 20 patients were collected 3 months post-SARS-CoV-2 infection. Samples underwent freezing and vitrification. Molecular and cellular analysis separated seminal plasma and pellets. Flow cytometry characterized immune cells. Viral RNA was extracted from plasma and sperm, followed by RT-qPCR. Cytometric Bead Array measured cytokine levels.</p><p><strong>Results: </strong>Angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) receptors were detected in both plasma and sperm fractions. Five patients exhibited viral RNA-dependent RNA polymerase, indicating potential persistence. Elevated inflammatory cytokines in plasma implied persistent inflammation affecting sperm vitality. Immune cells associated with viral clearance were identified in semen, correlating with receptor expression and cytokines. Both conventional freezing and vitrification were found safe procedures for preserving male fertility.</p><p><strong>Conclusions: </strong>Our study highlights the impact of SARS-CoV-2 on male reproductive health, emphasizing the persistence of viral entry receptors, potential viral RNA presence, the inflammatory environment, and the involvement of immune populations in the male reproductive tract post-infection. Importantly, we confirm the safety of conventional freezing and vitrification techniques for preserving male fertility in assisted reproductive technology programs amidst the COVID-19 pandemic.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"577-587"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FXYD1 was identified as a hub gene in recurrent miscarriage and involved in decidualization via regulating Na/K-ATPase activity.","authors":"Jie Gan, Long Yang, Shu-Han Yang, Wen-Wen Gu, Yan Gu, Yan Shi, Jia-Xin Shi, Hao-Ran Xu, Ya-Wei Xin, Xuan Zhang, Jian Wang","doi":"10.1007/s10815-024-03363-8","DOIUrl":"10.1007/s10815-024-03363-8","url":null,"abstract":"<p><strong>Purpose: </strong>Recurrent miscarriage (RM) is a distressing and complicated adverse pregnancy outcome. It is commonly recognized that insufficient decidualization could result in RM, but the molecular mechanisms of decidual impairment are still not fully understood. Thus, this study aimed to identify novel key genes potentially involved in RM and explore their roles played in endometrial decidualization.</p><p><strong>Methods: </strong>Initially, a combinative analysis of decidual and mid-secretory endometrial transcriptomes was performed to discover hub genes involved in the etiology of RM. And the expression levels of hub genes were evaluated in both primary decidual stromal cells (DSCs) and decidual tissues. Subsequently, the immortalized human endometrial cell line, T-HESCs, was used to investigate whether FXYD1 overexpression affects decidualization by regulating Na/K-ATPase activity.</p><p><strong>Results: </strong>FXYD domain containing ion transport regulator 1 (FXYD1) was identified as a hub gene in the pathogenesis of RM through various bioinformatic methods. Abnormally increased FXYD1 expression was observed in DSCs and decidual tissues from RM patients compared to that of the normal group. Furthermore, in vitro decidualization was obviously inhibited by the overexpression of FXYD1. Additionally, Na/K-ATPase activity was significantly elevated during decidualization, whereas overexpression of FXYD1 reduced Na/K-ATPase activity. Bufalin, a Na/K-ATPase inhibitor, showed an effectively inhibitory effect on decidualization.</p><p><strong>Conclusions: </strong>Collectively, FXYD1 was discovered as a hub gene associated with RM, and its expression levels in RM patients were significantly upregulated. Increased FXYD1 expression might lead to decidualization defects by reducing Na/K-ATPase activity, of which presented a novel prospective treatment target for RM.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"665-678"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Comparison of obstetrical and neonatal outcomes between fresh versus frozen-thawed testicular sperm derived from microTESE.","authors":"Sima Simcha Nagawkar Perlov, Noy Deri, Talia Eldar-Geva, Michael Gal, Orna Reichman, Yuval Or, Ido Ben-Ami","doi":"10.1007/s10815-024-03384-3","DOIUrl":"10.1007/s10815-024-03384-3","url":null,"abstract":"","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"689"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing oncofertility care in limited resource settings: a narrative review.","authors":"Dana Kimelman, Noelle Ozimek","doi":"10.1007/s10815-025-03392-x","DOIUrl":"10.1007/s10815-025-03392-x","url":null,"abstract":"<p><strong>Purpose: </strong>While the literature has addressed the implementation of oncofertility care at developed institutions, minimal advice exists for those seeking to build oncofertility programs in limited resource settings (LRS). Our research offers a promising conversation on establishing oncofertility care in such settings from the perspective of a practitioner working to establish care in Latin America. We propose practices that have the potential to significantly improve access to and quality of care in these challenging settings.</p><p><strong>Methods: </strong>PubMed was used to identify articles on fertility preservation (FP) in LRS for this narrative review. Eligible articles were published between January 2010 and May 2023, available in English and include two or more key phrases: \"oncofertility care,\" \"limited resources,\" \"low-income settings,\" \"limiting access,\" and \"fertility preservation.\"</p><p><strong>Results: </strong>As each institution faces a unique profile of medical, financial, geographical, cultural, and legal considerations, it is difficult to generalize an approach to optimizing care. However, the success of many programs is underpinned by collaborative efforts to educate and support healthcare specialists across the globe. National and international clinical guidelines, an unparalleled opportunity to promote the maintenance of a high level of care, do not exist for many Oncofertility practices. It is necessary that future guidelines consider barriers unique to implementing care in LRS as historically, guidelines have not done so, leaving LRS practitioners to deviate from the standard of care without consensus on how to best do so.</p><p><strong>Conclusion: </strong>It is crucial to consider the unique challenges in low-resource settings when strategizing the expansion of oncofertility efforts, optimizing care, and developing clinical guidelines. Addressing the diverse barriers to care requires multifaceted initiatives at local, national, and international levels.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"647-653"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of modified natural cycle vs. hormone replacement therapy in oocyte donation for recipients of advanced maternal age: a retrospective study.","authors":"Cristina Gavilan, Juan Carlos Castillo, Jose Antonio Ortiz, Judith Morraja, Cecilia Quetglas, Andrea Bernabeu, Rafael Bernabeu","doi":"10.1007/s10815-024-03376-3","DOIUrl":"10.1007/s10815-024-03376-3","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the efficacy of modified natural cycle (mNC) preparation versus hormone replacement therapy (HRT) for endometrial preparation in recipients of donated oocytes, specifically focusing on pregnancy rates in women of advanced maternal age.</p><p><strong>Methods: </strong>Retrospective multicenter analysis conducted between 2021 and 2024. It includes 220 cycles of fresh single blastocyst transfers resulting from oocyte donation. The participants were divided into two groups based on their endometrial preparation method: modified natural cycle (nNC) (n = 105, 47.7%) and hormone replacement therapy (HRT) (n = 115, 52.3%). Ongoing pregnancy rate was the main outcome.</p><p><strong>Results: </strong>Both groups were similar in terms of donor (24.8 vs 25.1 years) and recipient age (42.3 vs 42.8 years), BMI, and the origin of the semen used. The ongoing pregnancy rate was comparable between the mNC group (44.8%) and the HRT group (40.0%), showing no significant difference (p = 0.47). The mNC group had significantly higher progesterone levels compared to the HRT group (26.45 vs. 16.63, respectively; p < 0.001). In the multivariate analysis, which accounted for factors such as donor and recipient age, BMI, semen origin, progesterone levels, and endometrial thickness, no significant differences were observed between the two groups for the main outcome of ongoing pregnancy rate.</p><p><strong>Conclusions: </strong>The use of a modified natural cycle for endometrial preparation in advanced-age recipients of fresh single blastocyst transfers from vitrified donor oocytes results in ongoing pregnancy rates equivalent to those achieved with hormone replacement therapy.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"433-439"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting defects: low initial serum human chorionic gonadotropin (hCG) level may predict future fetal anomalies following frozen embryo transfer (FET).","authors":"Elise Heisler, Emily Weidenbaum, Jennifer K Blakemore","doi":"10.1007/s10815-024-03325-0","DOIUrl":"10.1007/s10815-024-03325-0","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between early serum hCG levels after frozen embryo transfer and fetal anomalies.</p><p><strong>Methods: </strong>This was a case-control study at a single academic fertility center between 1/2010 and 12/2021, including all patients who underwent euploid frozen embryo transfers resulting in any fetal anomaly confirmed at the time of induced abortion > 10 weeks or any anomaly reported at delivery. Controls included patients with healthy live births matched for age and day/grade of embryo after euploid FET. The primary outcome was fetal anomaly, with comparisons made using serum hCG levels from cycle day 28 to cycle day 35 and percent change between days 28 and 35.</p><p><strong>Results: </strong>Both cycle day 28 serum hCG levels and day 35 serum hCG levels were significantly lower in the anomalous group (day 28: 152 vs 177.5 mIU/mL, p < 0.04; day 35: 3033 vs 3744 mIU/mL, p < 0.05). Patients with anomalous outcomes had a significantly lower hCG to start with 5/78 (6.4%) < 50 mIU/mL, 16/78 (20.5%) 51-100 mIU/mL, and 57/78 (73.1%) > 101 mIU/mL, compared to controls 3/78 (3.8%) < 50 mIU/mL, 8/77 (10.3%) 51-100 mIU/mL, and 66/77 (85.7%) > 101 mIU/mL (p < 0.02). However, the rate of rise between day 28 and day 35 was not statistically different (1758.0% vs 2097.0%, p = 0.23).</p><p><strong>Conclusion: </strong>Patients with anomalous fetal outcomes following frozen embryo transfer had lower early serum hCG levels than controls with healthy live births, highlighting the potential utility of this serum marker to identify high-risk pregnancies in the first trimester and expedite treatment as appropriate for this rare but devastating outcome.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"483-488"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emotions, concerns and reactions of sperm donor candidates to their rejection by a sperm bank.","authors":"Guido Pennings, Emilie Lassen, Josephine G Lemmen, Lina Thirup, Allan Pacey, Anne-Bine Skytte","doi":"10.1007/s10815-024-03357-6","DOIUrl":"10.1007/s10815-024-03357-6","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the emotions, concerns and reactions of sperm donor candidates to their rejection by the sperm bank.</p><p><strong>Methods: </strong>An online questionnaire was administered at Cryos International in the USA and Denmark to sperm donor candidates who had received notification that they were ineligible to donate.</p><p><strong>Results: </strong>A total of 101 rejected donor candidates completed the questionnaire. The majority were disappointed and surprised by the rejection but only a relatively small group had concerns about their health, fertility or manhood. More than half of them (54.5%) were satisfied with the way they were informed of their ineligibility while 17.8% were neutral, and 27.7% were dissatisfied. Approximately half (47.5%) thought that the information provided to them was sufficient while 24.8% were neutral and one in four (27.8%) considered it as insufficient. The most frequent suggestions for improvement were to provide an information leaflet specific to the reason of rejection, offer personal counselling and explain better what the implications are for them.</p><p><strong>Conclusion: </strong>There is room for improvement in the information provided to donor candidates about the reason for their rejection. Although some information is already currently provided, a minority of donor candidates considered this to be insufficient. However, rejected candidates do not request more information on their own initiative. Routine provision of an information sheet specific to each reason for rejection may improve the experience of these men.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"451-457"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum vitamin D level and live birth rate in women undergoing frozen embryo transfer-a retrospective cohort study.","authors":"Jennifer K Y Ko, Mei Ting Lam, Kevin K W Lam, Tat On Chan, Raymond H W Li, Ernest H Y Ng","doi":"10.1007/s10815-024-03326-z","DOIUrl":"10.1007/s10815-024-03326-z","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the association of serum vitamin D level and the live birth rate in women undergoing frozen embryo transfer (FET).</p><p><strong>Methods: </strong>This is a retrospective cohort study involving 1489 infertile women who had frozen embryo transfer at two tertiary reproductive medicine centres from 2019 to 2021. Only the first frozen embryo transfer was included for women who had repeated transfers during the period. Archived serum samples taken at LH surge or before the start of progestogens for FET were analysed for 25(OH)D levels using mass spectrometry. The main outcome measure was the live birth rate. Vitamin D deficiency was defined as serum 25(OH)D < 50 nmol/l (< 20 ng/ml) based on the Endocrine Society Clinical Practice guidelines.</p><p><strong>Results: </strong>The median age was 36 (25th-75th percentile 34-38) years. 37.7% (561/1489) women had cleavage stage embryo transfer and 62.3% (928/1489) women had blastocyst transfer. When analysing the results based on the threshold in the Endocrine Society guideline of 50 nmol/l (20 ng/ml) for vitamin D deficiency, there were no statistically significant differences in the live birth rate in the vitamin D deficient and non-deficient groups [151/489 (30.9%) vs 341/998 (34.2%), OR 0.861, 95% CI 0.683-1.086 P = 0.205]. There were no statistically significant differences in the pregnancy rates, ongoing pregnancy rates, and miscarriage rates between the two groups.</p><p><strong>Conclusion: </strong>Serum vitamin D is not associated with birth rate in women undergoing FET.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"509-523"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a novel calculator to predict gonadotropin dose and oocyte yield in oocyte cryopreservation cycles.","authors":"Bahar D Yilmaz, Jennifer Bakkensen, Chen Yeh, Lutfiyya N Muhammad, Eve C Feinberg","doi":"10.1007/s10815-024-03372-7","DOIUrl":"10.1007/s10815-024-03372-7","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a predictive model for estimating the total dose of gonadotropins and the number mature oocytes in planned oocyte cryopreservation cycles.</p><p><strong>Methods: </strong>In this retrospective study, oocyte cryopreservation cycles recorded in the Society for Assisted Reproductive Technology Clinic Outcome Reporting System Database from 2013 to 2018 were analyzed. Bivariate copula additive models for location, scale, and shape were performed to create a predictive model for estimating total dose of gonadotropins and number of mature oocytes.</p><p><strong>Results: </strong>A total of 15,806 oocyte cryopreservation cycles between 2013 and 2018 were included in the analysis. The average age of participants was 35.4 years, the mean duration of stimulation was 11.8 days, and the average number of mature oocytes retrieved was 11.8. The treatment dose increased with age, FSH levels, BMI ≥ 35 kg/m², smoking, and history of diminished ovarian reserve, while it decreased with increasing AMH, ovulatory disorder, and BMI < 25 kg/m². The number of mature oocytes retrieved was positively correlated with AMH and negatively correlated with age, FSH levels, Asian race, and diminished ovarian reserve. With a maximum gonadotropin dosage of 450 IU per day for 12 ± 3 days of stimulation and a tolerance level of six mature oocytes, the predictive model achieved 70% accuracy. An interactive version of the equation was created as an online tool.</p><p><strong>Conclusions: </strong>We developed a predictive model to estimate the total treatment dosage and the number of mature oocytes. This calculator, utilizing objective patient variables, can assist in patient counseling prior to planned oocyte cryopreservation cycles.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"423-432"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}