A Salame, B Lawrenz, E Kalafat, R Del Gallego, I ElKhatib, A Bayram, H Fatemi
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The ratio measured to expected hCG levels was significantly lower in patients with ectopic pregnancy when compared to those with clinical pregnancy (0.7 vs 1, P < 0.001). The multinomial regression analysis showed increased odds of an ectopic pregnancy (EP) compared to an ongoing clinical pregnancy with lower observed/expected hCG levels in both single and double embryo transfers (OR, 0.4; 95% CI, 0.07-0.25; P < 0.001 and OR, 0.16; 95% CI, 0.09-0.30; P < 0.001).</p><p><strong>Conclusion: </strong>The risk of ectopic pregnancy in euploid frozen embryo transfer cycles at the blastocyst stage is comparable to spontaneous conceptions. Despite the huge sample size of euploid FET cycles, due to the very low number of ectopic pregnancies, we were unable to identify a particular risk factor for ectopic implantation.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessing the risk of ectopic pregnancy following euploid frozen embryo transfer: a retrospective cohort study.\",\"authors\":\"A Salame, B Lawrenz, E Kalafat, R Del Gallego, I ElKhatib, A Bayram, H Fatemi\",\"doi\":\"10.1007/s10815-025-03560-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate possible risk factors for an ectopic pregnancy after euploid frozen embryo transfer (FET) at blastocyst stage.</p><p><strong>Methods: </strong>Retrospective cohort study of women with a positive pregnancy test after euploid frozen embryo transfer at blastocyst stage between April 2017 and June 2023.</p><p><strong>Results: </strong>An ectopic pregnancy occurred in 21 patients (1.19%) out of 1758 patients. 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引用次数: 0
摘要
目的:探讨整倍体冷冻胚胎移植(FET)在囊胚期发生异位妊娠的可能危险因素。方法:回顾性队列研究2017年4月至2023年6月期间囊胚期整倍体冷冻胚胎移植后妊娠试验阳性的女性。结果:1758例患者中发生异位妊娠21例(1.19%)。患者特征年龄、BMI、吸烟状况、不孕症类型、周期/胚胎特征(子宫内膜准备类型和胚胎质量)以及是否存在峡部膨出(是/否)在异位妊娠患者与非异位妊娠患者之间无显著差异。与临床妊娠患者相比,异位妊娠患者的测量值与预期hCG水平的比值显著低于临床妊娠患者(0.7 vs 1, P)。结论:在囊胚期整倍体冷冻胚胎移植周期中,异位妊娠的风险与自然受孕相当。尽管整倍体FET周期的样本量很大,但由于异位妊娠的数量非常少,我们无法确定异位植入的特定危险因素。
Assessing the risk of ectopic pregnancy following euploid frozen embryo transfer: a retrospective cohort study.
Purpose: To evaluate possible risk factors for an ectopic pregnancy after euploid frozen embryo transfer (FET) at blastocyst stage.
Methods: Retrospective cohort study of women with a positive pregnancy test after euploid frozen embryo transfer at blastocyst stage between April 2017 and June 2023.
Results: An ectopic pregnancy occurred in 21 patients (1.19%) out of 1758 patients. Patient characteristics age, BMI, smoking status, infertility type, cycle/embryo characteristics (type of endometrial preparation and embryo quality), and presence of an isthmocele (yes/no) were not significantly different between the patients with versus without an ectopic pregnancy. The ratio measured to expected hCG levels was significantly lower in patients with ectopic pregnancy when compared to those with clinical pregnancy (0.7 vs 1, P < 0.001). The multinomial regression analysis showed increased odds of an ectopic pregnancy (EP) compared to an ongoing clinical pregnancy with lower observed/expected hCG levels in both single and double embryo transfers (OR, 0.4; 95% CI, 0.07-0.25; P < 0.001 and OR, 0.16; 95% CI, 0.09-0.30; P < 0.001).
Conclusion: The risk of ectopic pregnancy in euploid frozen embryo transfer cycles at the blastocyst stage is comparable to spontaneous conceptions. Despite the huge sample size of euploid FET cycles, due to the very low number of ectopic pregnancies, we were unable to identify a particular risk factor for ectopic implantation.
期刊介绍:
The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species.
The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.