Journal of Assisted Reproduction and Genetics最新文献

{"title":"Urgent fertility preservation following second trimester termination in a patient with pregnancy-associated colorectal cancer: a case report and literature review.","authors":"Anne E Kim, Pak H Chung, Joshua D Stewart, Zev Rosenwaks","doi":"10.1007/s10815-025-03775-0","DOIUrl":"10.1007/s10815-025-03775-0","url":null,"abstract":"<p><p>We report a case of fertility preservation using random-start controlled ovarian stimulation and embryo cryopreservation in a patient with a recent second trimester termination. A 32-year-old patient at 17 weeks of gestation was diagnosed with advanced colorectal cancer after presenting with hematochezia and acute blood loss anemia. To initiate urgent chemotherapy, the patient underwent an elective termination at 18-week gestation. Random-start controlled ovarian stimulation (COS) was initiated seven days later using a gonadotropin-releasing hormone antagonist protocol. Despite a β-human chorionic gonadotropin level of 52.4 mIU/mL, ovarian stimulation was started. Nineteen oocytes were retrieved after 10 days of ovarian stimulation, of which 15 were mature. Eleven mature oocytes fertilized successfully using intracytoplasmic sperm injection. All 11 embryos developed into the blastocyst stage and underwent biopsy for preimplantation genetic testing for aneuploidy screening. Five blastocysts were found to be euploid. The patient subsequently initiated chemotherapy seven days after her oocyte retrieval. This case highlights the feasibility of random-start COS and embryo cryopreservation for fertility preservation immediately after a second trimester termination in a patient with newly diagnosed colorectal cancer.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"895-899"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of referral for fertility preservation counseling in patients diagnosed with cancer.","authors":"Paris N Chey, Miranda L M Delwalla, Julia Shuford, Natalie Albright, Katharina Goebel, Julia Grigorian, Sheila Rajagopalan, D Austin Schirmer, Heather S Hipp","doi":"10.1007/s10815-025-03784-z","DOIUrl":"10.1007/s10815-025-03784-z","url":null,"abstract":"<p><strong>Objective: </strong>Fertility preservation (FP) is an important aspect of care for reproductive-aged cancer patients since treatment can significantly impact fertility. Despite professional recommendations for early referral to FP, rates remain low. This study evaluates predictors of FP referrals by Oncologists to Reproductive Endocrinology and Infertility (REI) physicians among reproductive-aged cancer patients at a large academic institution.</p><p><strong>Materials and methods: </strong>This cross-sectional study evaluated patients ages 14-42 years seen by an Oncologist from 2022 to 2024 with a new diagnosis of cancer for whom planned treatment is either gonadotoxic or requires delayed pregnancy. Referral rates to REI physicians were assessed by patient demographics and cancer and Oncologist characteristics as potential predictors. Statistical analysis used chi-square tests, Fisher's exact tests, and multivariable logistic regression.</p><p><strong>Results: </strong>Of 510 patients seen by an Oncologist for a newly diagnosed cancer, only 127 (22.5%) were referred for FP. Patients > 30 years were less likely to be referred than younger patients (aOR = 0.15, 95% CI = 0.05, 0.47, p = 0.001). Patients with breast cancer were most likely to be referred compared to other cancers. There was no difference in referral rates by physician gender. Physicians with 21-30 years of experience were more likely to refer than those with < 10 years (aOR = 2.89, 95% CI = 1.50, 5.62, p = 0.002).</p><p><strong>Conclusions: </strong>There was a low rate of FP referral and significant disparities based on patient demographics and clinical factors. Referral rates were higher among younger patients and breast cancer patients. Standardizing FP referrals across oncology specialties, consideration of electronic health record \"soft stops\" for referral and increasing patient and provider education are essential to improving referral rates.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"873-893"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the VEGF-ETS1 axis: a transcriptomic and single-cell analysis of angiogenesis in endometriosis.","authors":"Xiaoxuan Liu, Ran An, Ping Zhang, Qi Yang, Shuang Wang, Xue Jiao, Le Xu, Qianhui Ren, Guoyun Wang","doi":"10.1007/s10815-025-03781-2","DOIUrl":"10.1007/s10815-025-03781-2","url":null,"abstract":"<p><strong>Purpose: </strong>Endometriosis (EM) is a chronic inflammatory gynecological disorder characterized by ectopic endometrial-like lesions, where aberrant angiogenesis is a hallmark driving lesion establishment and progression. However, the transcriptional mechanisms underlying pathological vascular remodeling in EM remain unclear.</p><p><strong>Methods: </strong>In this study, we identified E26 transformation-specific 1 (ETS1) as a key transcriptional regulator in EM pathogenesis through integrative analysis of bulk and single-cell transcriptomic datasets.</p><p><strong>Results: </strong>Across three independent transcriptome datasets and two validation cohorts, ETS1 expression was consistently elevated in endometriosis lesions, particularly in ovarian endometrioma. Single-cell RNA sequencing further revealed that ETS1 was predominantly expressed in endothelial cells and dynamically upregulated along the endothelial differentiation trajectory. Functional enrichment and pseudotime analyses indicated that ETS1 + endothelial cells exhibited enhanced angiogenic activity and vascular remodeling potential. Mechanistically, ETS1 amplified VEGF signaling by upregulating VEGFR1 and VEGFR2, while macrophage-derived VEGFA acted as the principal upstream activator within the lesion microenvironment.</p><p><strong>Conclusions: </strong>Collectively, our findings delineate the VEGF-ETS1 axis as a central driver of pathological angiogenesis in endometriosis, positioning ETS1 as both a mechanistic hallmark and a promising therapeutic target for endometriosis.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"979-995"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovary laparoscopic incision and intraovarian platelet-rich plasma induce distinct cortical stiffness changes and follicular activation in aged sheep-a pilot study.","authors":"Marta Méndez Justo, Janisse Ferreri Dos Anjos, Carolina Herranz-Diez, Jordi Otero Diaz, Jose Antonio Domínguez Arroyo, Ignacio Santiago Álvarez Miguel, Soledad Sanchez Mateos, Josep Maria Calafell, Salvadora Civico Vallejos, Ester Parraga, Ramon Farre, Francisco Miguel Sanchez Gargallo, Francesc Fabregues Gasol","doi":"10.1007/s10815-025-03780-3","DOIUrl":"10.1007/s10815-025-03780-3","url":null,"abstract":"<p><strong>Purpose: </strong>Poor ovarian response and primary ovarian insufficiency remain major challenges in assisted reproductive technologies. Recent advances propose mechanical approaches-such as in vitro activation, drug-free IVA, and whole ovarian laparoscopic incision (WOLI)-as well as biological strategies like platelet-rich plasma (PRP) injections to improve ovarian function. This study aims to evaluate the impact of WOLI and PRP on ovarian follicular activation, with a particular focus on the associated biomechanical alterations in the ovarian cortex.</p><p><strong>Methods: </strong>Experimental pilot study includes six aged female Merino sheep. Group A underwent WOLI on one ovary, and group B received PRP injections. Contralateral ovaries served as controls. Laparoscopic bilateral oophorectomies were performed at 2, 4, and 6 months. Atomic force microscopy (AFM) measured ovarian cortical stiffness, and histological analysis assessed follicular activation. Analyses were performed by comparing the operated ovary to the contralateral, non-operated ovary.</p><p><strong>Results: </strong>AFM measurements showed that in group A, ovarian stiffness significantly increased at 6 months (8.683 kPa vs. 5.551 kPa; p < 0.001), with no significant differences at 2 or 4 months. In group B, stiffness increased significantly at 2 months (11.177 kPa vs. 6.590 kPa; p < 0.001), but not at 4 or 6 months post-intervention. Growing follicle proportions differed between treated and control ovaries respectively, with activation at 2 months (58.95% vs. 29.73%) in group A and 6 months in group B (53.01% vs. 20.33%).</p><p><strong>Conclusion: </strong>The study suggests that the activating effect on ovarian folliculogenesis of both the surgical procedure and PRP administration shows a different time course and that could be related to its effect on ovarian cortex mechanobiology.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"901-910"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA damage control in IVF: precariously positioned between physiology and disease.","authors":"David F Albertini","doi":"10.1007/s10815-026-03844-y","DOIUrl":"10.1007/s10815-026-03844-y","url":null,"abstract":"","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"687-688"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABO blood group distribution and infertility risk in Southern China: a retrospective analysis of the Ganzhou Region.","authors":"Min Liu, Jiedong Zhou, Shian Hu, Yong Ouyang, Yuting Xiong, Ying Zhao","doi":"10.1007/s10815-025-03783-0","DOIUrl":"10.1007/s10815-025-03783-0","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the distribution of ABO blood groups among infertile couples in Southern China (Ganzhou region) and to explore the association between blood types and male reproductive parameters.</p><p><strong>Methods: </strong>This single-center retrospective study analyzed data from 696 infertile couples who sought treatment at a tertiary reproductive medicine center in Southern China between 2016 and 2024. ABO blood group distributions in infertile men and women were compared with those of a large-scale reference population from Southern China (n ≈ 14.41 million). Chi-square tests, Cramér's V effect size, and the observed-to-expected ratio (O/E) were used to evaluate associations between couple blood type combinations and semen parameters, including sperm concentration, total sperm count, progressive motility, and normal morphology.</p><p><strong>Results: </strong>Blood group O was significantly overrepresented in infertile men (39.51% vs. 34.21%, P = 0.008) and women (41.67% vs. 34.19%, P < 0.001), whereas blood group AB was underrepresented (men: 6.18% vs. 8.91%, P = 0.008; women: 6.47% vs. 8.91%, P = 0.008). The O/O couple blood type combination showed a significantly higher prevalence among infertile couples (16.81% vs. 11.70%, O/E = 1.44, P < 0.001), while combinations involving A/B and B/AB occurred less frequently (O/E = 0.57-0.78, P < 0.05). Male blood type was associated with sperm normal morphology (O < A < B < AB, P = 0.02), but not with sperm concentration or progressive motility.</p><p><strong>Conclusion: </strong>Blood group O-particularly the O/O couple combination-may be associated with an increased risk of infertility, whereas combinations involving B or AB blood groups may confer a potential protective effect. The ABO blood group type may influence male fertility, partly through its association with sperm morphology. These findings provide region-specific evidence and underscore the need for large-scale, multi-center studies to further validate the observed associations.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"939-952"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of post-GnRH agonist trigger serum hormonal testing and effect on the incidence of empty follicle syndrome: a single-center retrospective cohort study.","authors":"Robert Kloosterman, Trish Dinh, Jennia Michaeli","doi":"10.1007/s10815-025-03776-z","DOIUrl":"10.1007/s10815-025-03776-z","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to assess whether discontinuing routine serum hormone testing following gonadotropin-releasing hormone (GnRH) agonist trigger affects the incidence of empty follicle syndrome (EFS) and embryological outcomes in controlled ovarian stimulation (COS) cycles.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 3834 COS cycles at a single fertility center from May 2020 to May 2024. Cycles were grouped based on post-trigger testing: 1964 with routine serum hormone measurement and 1870 without. The primary outcome was EFS, defined as failure to retrieve oocytes despite adequate follicular development. Secondary outcomes included the number of oocytes retrieved, mature oocytes, fertilization rates, and utilizable embryos.</p><p><strong>Results: </strong>The incidence of EFS did not significantly differ between groups (0.87% with testing vs. 1.07% without; p = 0.06). In GnRH agonist-triggered cycles, the incidence was 0.74% with testing and 0.96% without (p = 0.53). After adjusting for age, trigger medication type, and estradiol level, there was no significant difference in the odds of EFS (adjusted OR 1.26; 95% CI, 0.63 to 2.53; p = 0.52). Secondary outcomes showed statistically significant improvements in the group without testing: oocytes retrieved (mean 12.6 vs. 12.0; p = 0.03), mature oocytes (mean 7.3 vs. 6.4; p < 0.01), and embryos suitable for clinical use (mean 4.0 vs. 3.6; p < 0.01). Fertilization rates were similar between groups.</p><p><strong>Conclusion: </strong>The discontinuation of routine hormone testing following the GnRH agonist trigger did not increase the incidence of EFS and was associated with comparable embryological outcomes. These findings suggest that routine testing may be unnecessary in most cases, supporting a selective approach, potentially reducing clinical burden and cost without compromising patient care.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"771-778"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145810218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical luteinization of follicles before oocyte retrieval is often overlooked: a case report.","authors":"Marina Marks Kazatsker, Shahar Kol, Samer Khoury","doi":"10.1007/s10815-025-03758-1","DOIUrl":"10.1007/s10815-025-03758-1","url":null,"abstract":"<p><p>We describe a 26-year-old IVF patient, with primary infertility, who underwent oocyte retrieval following ovarian stimulation. During the procedure, we encountered premature follicular luteinization confined to large follicles in the right ovary, while the smaller follicles in the left ovary were not affected. Repeated blood tests in the late follicular phase ruled out premature LH rise and showed an abnormal progesterone rise. We maintain that ovarian tissue mechanical pressure may lead to abnormal follicular luteinization, independent of the LH surge.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"1025-1027"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145563122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of artificial intelligence in bovine reproductive assessment: focus on oocytes and blastocysts.","authors":"Bharati Pandey, Rutuja Shelke, Gaurav Tripathi, Manoj K Singh, Naresh L Selokar","doi":"10.1007/s10815-025-03772-3","DOIUrl":"10.1007/s10815-025-03772-3","url":null,"abstract":"<p><p>The assessment of oocyte and blastocyst quality plays a pivotal role in reproductive biology, directly influencing the success of assisted reproductive technologies (ART) in both humans and farm animals. In livestock, technologies such as Ovum Pick-Up and In Vitro Embryo Production (OPU-IVEP) have revolutionized genetic improvement strategies by enabling the production of a higher number of genetically superior offspring from elite females. However, the manual evaluation of oocytes and embryos remains subjective, time-consuming, and susceptible to human error. Recent advances in Artificial Intelligence (AI), particularly in computer vision and deep learning, have opened new avenues for automating the assessment process. AI models such as convolutional neural networks (CNNs) have demonstrated high accuracy in classifying oocyte and embryo quality, providing standardized, rapid, and reproducible evaluations. This review focuses on the applications of artificial intelligence in bovine oocyte and blastocyst grading, highlighting its potential to improve assessment accuracy, support OPU-IVEP programs, and enhance reproductive efficiency.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"689-714"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility preservation in women with diminished ovarian reserve: evaluating the AMH criteria.","authors":"Maria Elisabetta Coccia, Benedetta Gabbrielli, Giulia Cutajar, Francesca Piazzini, Paolo Evangelisti, Laura Badolato, Patrizia Falcone, Rossella Fucci, Carlo Bulletti","doi":"10.1007/s10815-025-03779-w","DOIUrl":"10.1007/s10815-025-03779-w","url":null,"abstract":"<p><strong>Purpose: </strong>Does fertility preservation (FP) through oocyte cryopreservation provide realistic reproductive opportunities for diminished ovarian reserve (DOR)? Literature suggests cumulative live birth rates of 30-45% with 8-10 oocytes under 35 years old. Insufficient data exist to define whether DOR patients should be offered FP systematically.</p><p><strong>Methods: </strong>This retrospective single-center study analyzed data from 304 women undergoing oocyte cryopreservation (January 2016-December 2024). Patients were stratified into cohort 1 (Anti-Müllerian hormone-AMH-≤ 0.5 ng/mL, n = 49) and cohort 2 (AMH > 0.5 ng/mL, n = 255). Primary outcomes included retrieved oocytes (RO) and vitrified oocytes (VO). Secondary outcome examined DuoStim results. Statistical analysis included correlation assessments, ANCOVA, and multiple linear regression.</p><p><strong>Results: </strong>DOR patients achieved lower oocyte yields compared to cohort 2 (RO: 3.1 ± 2.3 vs. 9.0 ± 6.5; VO: 2.3 ± 1.9 vs. 7.4 ± 5.1; p < 0.001), despite higher gonadotropin doses. AMH strongly correlated with RO (ρ = 0.636, p < 0.001) and VO (ρ = 0.624, p < 0.001). Linear regression confirmed AMH (B = 1.151, p < 0.001) and age (B =  - 0.139, p = 0.002) as significant predictors of VO. In DuoStim subgroup, DOR patients achieved 3.3 ± 2.1 total VO compared to 6.9 ± 3.3 in cohort 2 (p = 0.001).</p><p><strong>Conclusion: </strong>DOR patients achieve oocyte yields substantially below thresholds associated with reasonable live birth rates, raising concerns regarding FP efficacy. These findings highlight the need for personalized counseling that considers individual patient characteristics and provides evidence-based, realistic expectations for FP. A revision of current AMH thresholds may improve patient selection and cost-effectiveness of FP programs. Younger DOR patients may benefit from oocyte cryopreservation for FP, emphasizing the importance of age stratification.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"865-872"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12982711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145833922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}