Journal of Assisted Reproduction and Genetics最新文献

{"title":"The newly enacted Italian surrogacy law: Effects on reproductive tourism.","authors":"Susanna Marinelli, Giuseppe Gullo, Francesco Circosta, Simona Zaami, Robert Krysiak, Gianluca Montanari Vergallo","doi":"10.1007/s10815-025-03545-y","DOIUrl":"10.1007/s10815-025-03545-y","url":null,"abstract":"<p><strong>Purpose: </strong>In Italy, Law No. 169 of November 4, 2024, has come into force, criminalizing surrogacy even if it occurs abroad, provided at least one member of the requesting couple is an Italian citizen. This legislation stems from a firm conviction that surrogacy undermines the dignity of the surrogate mother and places the child thus born in a more precarious situation, compared to a child born to a mother who intends to raise them as her own. The authors have set out to outline a brief overview of surrogacy legal frameworks in Europe and in the USA, as a meaningful sample of Western countries largely sharing a common set of values. The ultimate purpose is to assess the potential effectiveness of this new extremely restrictive Italian law in dissuading Italian couples from seeking surrogacy abroad.</p><p><strong>Materials and methods: </strong>First-hand sources (national legislative bodies) have been delved into to shed a light on national norms governing surrogacy in major European countries and the USA. Databases De Jure and Onelegale, along with international scientific databases PubMed and Scopus, were drawn upon through the search terms/strings: surrogate motherhood; surrogacy; extraterritorial jurisdiction.</p><p><strong>Results: </strong>This law's consistency with European Court of Human Rights (ECtHR) jurisprudence and European Union law is dubious: it in fact appears to conflict with freedom of movement within the European Union and the child's best interests. Moreover, while it may hinder the pursuit of parenthood, its effectiveness in preventing reproductive tourism is still unclear.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"2515-2525"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three different protocols for pituitary suppression: progestins (dydrogesterone or medroxyprogesterone acetate) versus GnRH antagonist-balancing efficacy and cost in ovarian stimulation.","authors":"Pınar Özcan, Emre Goksan Pabuccu, Ege Mertoğlu, Tunç Timur, Elif Cigdem Keleş, Bilge Pınar Keskinsoy, Recai Pabuççu","doi":"10.1007/s10815-025-03555-w","DOIUrl":"10.1007/s10815-025-03555-w","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the clinical effectiveness and overall treatment cost of three ovarian stimulation protocols-dydrogesterone (DYD), medroxyprogesterone acetate (MPA), and GnRH antagonist-in women undergoing in vitro fertilization (IVF).</p><p><strong>Methods: </strong>This prospective, multicenter cohort study was conducted at two IVF units from March 2023 to March 2024. A total of 307 women undergoing IVF were divided into three groups based on their pituitary suppression protocol: DYD (n = 99), MPA (n = 101), and GnRH antagonist (n = 107). Ovarian stimulation parameters, pregnancy outcomes, and detailed cost analyses were then compared across these groups.</p><p><strong>Results: </strong>The number of mature oocytes (MII) retrieved and follicular output rate (FOI) were comparable among the three groups (MII, p = 0.67; FOI, p = 0.74). Gonadotropin consumption and estradiol levels on trigger day were significantly higher in the MPA group (p < 0.001 and p = 0.009, respectively). Clinical pregnancy rates (DYD 37.4%, MPA 32.7%, GnRH antagonist 34.6%; p = 0.78) and ongoing pregnancy rates (DYD 32.3%, MPA 28.7%, GnRH antagonist 29.9%; p = 0.85) did not differ significantly among groups. While the LH suppression cost per cycle was highest in the GnRH antagonist group (257.7 USD), the total cycle cost for this group was the lowest, as it typically involves fresh embryo transfer compared to frozen embryo transfer (FET) in PPOS (progestin-primed ovarian stimulation) protocols.</p><p><strong>Conclusion: </strong>PPOS protocols (DYD or MPA) offer clinical outcomes comparable to the GnRH antagonist protocol. While PPOS regimens may provide cost advantages in freeze-all settings due to lower LH suppression, the overall economic benefit hinges on the embryo transfer strategy. Therefore, optimal protocol selection should be individualized, considering both clinical characteristics and cost.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"2737-2746"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing programmed, modified natural and natural cycle frozen embryo transfer on obstetric outcomes in polycystic ovary syndrome: a national cohort study.","authors":"Eun Hee Yu, Hyun Joo Lee, Jong Kil Joo, Yong Jin Na","doi":"10.1007/s10815-025-03523-4","DOIUrl":"10.1007/s10815-025-03523-4","url":null,"abstract":"<p><strong>Purpose: </strong>Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with adverse reproductive and obstetric outcomes, particularly in pregnancies achieved through assisted reproductive technologies. This study aimed to compare obstetric outcomes among programmed cycle-frozen embryo transfer (PC-FET), modified natural cycle-frozen embryo transfer (mNC-FET), and natural cycle-frozen embryo transfer (NC-FET) in women with PCOS using a nationwide Korean health claims database.</p><p><strong>Methods: </strong>This population-based cohort study utilized data from the National Health Insurance Service-National Health Information Database of South Korea. A retrospective analysis was conducted on 3,873 PCOS patients with singleton pregnancies following FET between October 2017 and December 2021. Patients were categorized into PC-FET, mNC-FET, and NC-FET groups based on prescription records. Obstetric outcomes were analyzed using logistic regression models adjusted for age and medical comorbidities.</p><p><strong>Results: </strong>mN-FET was associated with significantly lower rates of miscarriage (23.9%) compared to PC-FET (31.3%) and NC-FET (32.0%), as well as a higher term birth rate (69.6% vs. 61.7% and 60.2%, respectively). mNC-FET also showed significantly lower rates of hypertensive disorders of pregnancy, gestational hypertension, cesarean section, and emergency cesarean section compared to PC-FET. No significant differences were observed between mNC-FET and NC-FET in most obstetric complications.</p><p><strong>Conclusion: </strong>mNC-FET was associated with favorable obstetric outcomes compared to PC-FET and NC-FET in women with PCOS. These findings suggest that mNC-FET may be an effective and safer endometrial preparation strategy in this population. Further prospective studies are needed to validate these results and optimize FET protocols based on individual patient characteristics.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"2727-2735"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Identification of Fowler syndrome (hydrocephaly-hydranencephaly proliferative vasculopathy) in a pregnancy following single euploid embryo transfer.","authors":"Victoria Lazarov, Atoosa Ghofranian, Daniella Wilner, Alan B Copperman, Rachel B Danis","doi":"10.1007/s10815-025-03623-1","DOIUrl":"10.1007/s10815-025-03623-1","url":null,"abstract":"","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"2655"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a live birth prediction model for single euploid frozen embryo transfer using machine learning: a novel approach.","authors":"Tiantaixi Tu","doi":"10.1007/s10815-025-03568-5","DOIUrl":"10.1007/s10815-025-03568-5","url":null,"abstract":"","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"2801-2802"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-viscosity oil does not offer enhanced protection for osmolality changes in high-volume media drops during extended dry incubation.","authors":"Louise Murray, Nairuti Patel, Sinan Ozkavukcu, Federica Lopes","doi":"10.1007/s10815-025-03586-3","DOIUrl":"https://doi.org/10.1007/s10815-025-03586-3","url":null,"abstract":"<p><strong>Purpose: </strong>While new technologies support undisturbed embryo culture, non-humidified incubation raises concerns about medium stability. High-viscosity oil (HVO) was proposed to maintain osmolality, but its validation remains limited. This study investigates whether HVO offers advantages over conventional light oil (CLO) in preventing evaporation during extended dry incubation using a high-volume media drop setting and its impact on embryo development and temperature control.</p><p><strong>Methods: </strong>HVO and CLO were overlaid on embryo culture media drops and incubated for 5 days under either dry or humid conditions. At various intervals throughout the experiment, measurements of osmolality, pH, temperature, and sodium concentration were taken. To assess toxicity, mouse embryo assays and lipid peroxidation detection were conducted in post-culture media.</p><p><strong>Results: </strong>The dry incubation significantly increased osmolality and sodium concentrations, regardless of oil type, from the first day of incubation, under the current experimental conditions. After 5 days of incubation, HVO was not superior to CLO in preventing these changes under dry conditions (289.867 ± 1.10 vs. 284.93 ± 1.03, respectively, p > 0.05). The mean osmolality values in CLO vs. HVO in dry conditions provided mild protection against temperature loss when dishes were removed from incubators and exposed to room temperature for 5 min, simulating a suboptimal setting. No significant differences were observed between HVO and CLO regarding lipid peroxidation or embryo development.</p><p><strong>Conclusion: </strong>These findings indicate that a high-viscosity oil does not confer better protection against evaporation than a conventional oil when uninterrupted culture is performed in dry incubation and high-volume media drops are used.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does ovarian morphology type affect the reproductive outcomes of in-vitro maturation cycles in polycystic ovary syndrome?","authors":"Alyssa Hochberg, Shai Elizur, Bernice Goorah, Samer Tannus, Weon Young Son, Michael H Dahan","doi":"10.1007/s10815-025-03610-6","DOIUrl":"https://doi.org/10.1007/s10815-025-03610-6","url":null,"abstract":"<p><strong>Purpose: </strong>To examine whether ovarian morphology in polycystic ovary syndrome (PCOS) affects reproductive outcomes in in-vitro-maturation (IVM) cycles.</p><p><strong>Methods: </strong>A two-year, single-center retrospective cohort study including PCOS patients undergoing IVM. PCOS diagnosis followed the 2003 Rotterdam criteria, and all subjects had a sonographic criterion (≥ 12 follicles in one ovary). Patients were categorized based on ovarian morphology imaged by trans-vaginal ultrasonography: i)peripheral cystic pattern (PCP), with follicles at the ovarian periphery; ii)general cystic pattern (GCP), with follicles dispersed throughout the ovarian stroma.</p><p><strong>Results: </strong>Of 127 subjects, 72 were in the PCP group and 55 in the GCP group. Women with PCP, compared to GCP, had higher rates of hirsutism and oligomenorrhea, and a higher antral follicle count. IVM outcomes showed that women with PCP had significantly more total retrieved oocytes; additional metaphase II oocytes 24- and 48-h post-retrieval;total metaphase II oocytes; IVM metaphase II oocytes; total cleavage stage embryos; and total good-quality embryos. PRs and CPRs were comparable between groups. Multivariable logistic regression adjusting for ovarian morphology type, female age,male age, gravidity, and total testosterone levels, demonstrated that ovarian morphology was not associated with PR or CPR. However, PCP was a predictor for ≥ 10 retrieved oocytes (aOR 12.5, 95%CI 2.44-100,p = 0.003),and ≥ 15 retrieved oocytes (aOR 10, 95%CI 1.75-50,p = 0.009). Additionally, increasing gravidity was associated with a reduced likelihood of ≥ 10 retrieved oocytes (aOR 0.48, 95%CI 0.26-0.91,p = 0.024).</p><p><strong>Conclusions: </strong>PCP ovarian morphology in PCOS patients correlated with higher oocyte and mature oocyte yield, cleavage stage embryos,and good-quality cleavage stage embryos, while pregnancy outcomes were comparable.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oocyte cryopreservation for fertility preservation in transgender and gender diverse individuals: a SWOT analysis.","authors":"Julia E Barbe, Federico Del Vento, Dehlia Moussaoui, Victoria L Crofts, Michal Yaron, Isabelle Streuli","doi":"10.1007/s10815-025-03579-2","DOIUrl":"https://doi.org/10.1007/s10815-025-03579-2","url":null,"abstract":"<p><p>Gender affirming hormone therapy may be used to relieve dysphoria among transgender or gender-diverse individuals. However, the long-term effects of these treatments on reproductive health remain uncertain. Before initiating hormone therapy, it is essential that patients are fully informed about the potential impact on their reproductive capabilities. Fertility preservation options, such as oocyte cryopreservation, should be offered to gender diverse individuals who were assigned female at birth. To assist healthcare providers in navigating the complexities of fertility preservation for these patients, we conducted a SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis focused of oocyte cryopreservation. This analysis aims to ensure that decisions are both clinically sound and aligned with the patient's reproductive goals.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An efficient advanced YOLOv8 framework for sperm motility detection.","authors":"Chuanjiang Li, Wenjing Xia, Ang Li, Liangshou Gao, Chongming Zhang, Erlei Zhi, Zheng Li","doi":"10.1007/s10815-025-03589-0","DOIUrl":"https://doi.org/10.1007/s10815-025-03589-0","url":null,"abstract":"<p><strong>Purpose: </strong>Sperm motility detection is crucial for reproductive health research, which is closely related to human development. Due to the small size and fast movement of sperm, coupled with the complex background, traditional image processing methods can hardly obtain accurate detection results.</p><p><strong>Methods: </strong>To address these issues, an advanced YOLOv8-based sperm detection model is proposed, named YOLOv8-STA. First, the SPD_Conv structure is integrated into the backbone network to improve the ability for extracting fine-grained information about sperm targets. Secondly, in order to construct effective relationships between input features while preserving more original image information, the partial C2F modules in the backbone and neck networks of the YOLOv8 model are replaced with C2F-Triplet modules, which can capture interactions across dimensions, build channel, and spatial attentions with minimal parameters. Finally, a new 104 <math><mo>×</mo></math> 104 pixel small object detection head is added specifically in the detection layer to construct advanced feature maps.</p><p><strong>Results: </strong>Experimental results on the public EVISAN dataset show that the improved YOLOv8-STA model can increase the mAP@0.5 by 4.2% and mAP@0.5:0.95 by 5.4%, compared with the baseline YOLOv8 model.</p><p><strong>Conclusion: </strong>These experimental results verify the effectiveness and superiority of the proposed method in sperm motility detection.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigations on semen analysis capabilities and quality control measures in laboratories with different management modes.","authors":"Hong-Lin Li, Jin-Chun Lu, Chao Zhao, Xi Zhang","doi":"10.1007/s10815-025-03595-2","DOIUrl":"https://doi.org/10.1007/s10815-025-03595-2","url":null,"abstract":"<p><strong>Purpose: </strong>To perform a survey on the semen analysis capabilities and quality control measures of medical institutions conducting male infertility-related testing in Jiangsu, China, by the WeChat, aiming to explore the possibility of mutual recognition of testing results among different laboratories.</p><p><strong>Methods: </strong>This study designed a survey questionnaire consisting of 105 questions and investigated and compared semen analysis capabilities and quality control measures between regulated laboratories for assisted reproductive technology (RLART) and non-regulated laboratories for assisted reproductive technology (non-RLART) in Jiangsu, China.</p><p><strong>Results: </strong>RLART had higher percentages of technicians received training on the WHO manual (97.14% [34/35] vs. 57.14% [28/49], P < 0.01), dedicated rooms for semen collection (100% [35/35] vs. 24.49% [12/49], P < 0.01), adherence to the staining methods recommended by the WHO manual (100% [32/32] vs. 33.33% [11/33], P < 0.01), internal quality control for sperm concentration (77.14% [27/35] vs. 6.12% [3/49], P < 0.01), and participation in external quality assessment (74.29% [26/35] vs. 14.29% [7/49], P < 0.01) compared to non-PLART.</p><p><strong>Conclusions: </strong>Establishing unified recognition criteria for semen analysis laboratories and conducting regular supervision can improve semen analysis capabilities and promote mutual recognition of semen testing results.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}