An analysis of freeze-all cycles to investigate the association between elevated progesterone on day of trigger and oocyte quality.

IF 3.2 3区医学 Q2 GENETICS & HEREDITY

Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-05 DOI:10.1007/s10815-025-03528-z

Achraf Benammar, Catherine Racowsky, Katharine Correia, Maria-Teresa Hadchity, Marine Poulain, Paul Pirtea, Jean-Marc Ayoubi

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引用次数: 0

Abstract

Purpose: To investigate whether a premature rise in progesterone at the end of the follicular phase is adversely associated with oocyte quality in IVF cycles.

Methods: A retrospective cohort study including patients less than or equal to 40 years of age undergoing their first IVF/ICSI cycle between January 2017 and December 2021 with freeze-all involving D5 or D6 blastocysts. Main Outcome Measure(s) Cumulative live birth rate (cLBR) and cumulative sustained implantation rate (cSIR).

Result: (s) A total of 1,373 IVF/ICSI cycles were included and categorized into progesterone tertiles (T1: 0.10-0.96 ng/ml; T2: 0.97-1.63 ng/ml; T3: 1.64-9.62 ng/ml). The cLBRs for T1, T2, and T3 were 54.0%, 56.6%, and 52.9%, respectively, and the cSIRs were 54.4%, 56.8%, and 53.3%, respectively. After adjustment for age, peak estradiol, and total dose of gonadotropins used, the risk of cLBR was statistically significantly increased for women in T2 (RR 1.19, 95% CI 1.06-1.33) and T3 (RR 1.14, 95% CI 1.01-1.28) compared with T1. Similar results were obtained for cSIR. For cycles with 5-10 oocytes, a statistically significant positive association was observed between T3 progesterone:oocyte ratio for both cLBR (RR 1.78, 95% CI 1.22-2.60) and cSIR (RR 1.80, 95% CI 1.24-2.62) compared with T1 after adjusting for oocyte number, while no such association was observed for cycles with >10 oocytes retrieved (cLBR: RR 0.95, 95% CI 0.84-0.95; cSIR: RR 0.95, 95% CI 0.83-1.08).

Conclusion: Our findings do not support an adverse association between a premature rise in progesterone and oocyte quality. In normal responders, this rise may be beneficial.

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冻融周期分析探讨触发日孕酮升高与卵母细胞质量的关系。

目的：探讨在IVF周期中卵泡期结束时黄体酮过早升高是否与卵母细胞质量负相关。方法：一项回顾性队列研究，包括2017年1月至2021年12月期间接受第一次IVF/ICSI周期的年龄小于或等于40岁的患者，冷冻所有涉及D5或D6囊胚。主要观察指标：累积活产率（cLBR）和累积持续着床率（cSIR）。结果：(5)共纳入1373个IVF/ICSI周期，并将其分类为黄体酮组(T1: 0.10 ~ 0.96 ng/ml；T2: 0.97-1.63 ng/ml；T3: 1.64-9.62 ng/ml)。T1、T2、T3的clbr分别为54.0%、56.6%、52.9%，cSIRs分别为54.4%、56.8%、53.3%。在调整了年龄、雌二醇峰值和使用促性腺激素的总剂量后，与T1相比，T2 （RR 1.19, 95% CI 1.06-1.33）和T3 （RR 1.14, 95% CI 1.01-1.28）的女性发生cLBR的风险有统计学意义上的显著增加。cSIR也得到了类似的结果。对于5-10个卵母细胞的周期，与T1相比，调整卵母细胞数量后，T3孕酮：卵母细胞比值cLBR （RR 1.78, 95% CI 1.22-2.60）和cSIR （RR 1.80, 95% CI 1.24-2.62）与T1有统计学意义的正相关，而对于bbb10个卵母细胞的周期，没有观察到这种相关性(cLBR: RR 0.95, 95% CI 0.84-0.95；cSIR: RR 0.95, 95% CI 0.83-1.08)。结论：我们的研究结果不支持黄体酮过早升高与卵母细胞质量之间的不良关联。在正常反应者中，这种升高可能是有益的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.