Journal of Assisted Reproduction and Genetics最新文献

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Willingness to pay for in vitro fertilization: results from a national sample of reproductive-aged adults in the US. 支付体外受精费用的意愿:来自美国全国育龄成年人样本的结果。
IF 3.2 3区 医学
Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-04 DOI: 10.1007/s10815-025-03539-w
Sitara Murali, David Suh, S Sriram, Anna Kirkland, James M Dupree
{"title":"Willingness to pay for in vitro fertilization: results from a national sample of reproductive-aged adults in the US.","authors":"Sitara Murali, David Suh, S Sriram, Anna Kirkland, James M Dupree","doi":"10.1007/s10815-025-03539-w","DOIUrl":"https://doi.org/10.1007/s10815-025-03539-w","url":null,"abstract":"<p><strong>Purpose: </strong>To assess United States (US) reproductive-aged adults' willingness to pay for in vitro fertilization (IVF) and determine socio-demographic factors associated with their willingness to pay.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey of reproductive-aged adults (18-50 years old) to ask respondents demographic and reproductive health questions, including the US dollar amount they would be willing to pay out-of-pocket for IVF over a 12-month period. We used linear regression models to determine associations between socio-demographic factors and respondents' willingness to pay for IVF.</p><p><strong>Results: </strong>There were 2,035 survey respondents from 49 states and the District of Columbia. 43.6% were female assigned at birth, 81.7% were heterosexual, 42.6% were married, and 7.2% of respondents reported having infertility. 66% (n = 1,353) of respondents were willing to pay a non-zero amount for IVF, with a median willingness to pay of $5,000. Annual household incomes between $121,000 and $199,000 (p = 0.003) and greater than $200,000 (p = 0.005) and familiarity with IVF treatment (p < 0.001) were associated with a higher willingness to pay. Among infertile respondents (n = 133), the median willingness to pay was also $5,000 and familiarity with IVF (p = 0.04) was associated with a higher willingness to pay.</p><p><strong>Conclusion: </strong>We found a median willingness to pay for IVF of $5,000 among respondents, which is one-third of the average out-of-pocket cost of one IVF cycle in the US (~ $15,000). These findings highlight the need for policymakers and clinicians to advocate for expanded health insurance coverage for IVF to align with reproductive-aged adults' willingness to pay and address barriers accessing infertility services.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-resolution optical genome mapping unveils gene disruptions in a reciprocal chromosomal translocation and severe male infertility: a case report. 高分辨率光学基因组图谱揭示了互惠染色体易位和严重男性不育症的基因破坏:一个病例报告。
IF 3.2 3区 医学
Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-04 DOI: 10.1007/s10815-025-03521-6
Debbie Montjean, Walaa Darwiche, Nellie Fotopoulos, Marie-Hélène Godin Pagé, Raouf Fetni, Francis Petrella, Marie-Claire Bélanger, Guillaume Jedraszak, Moncef Benkhalifa, Pierre Miron
{"title":"High-resolution optical genome mapping unveils gene disruptions in a reciprocal chromosomal translocation and severe male infertility: a case report.","authors":"Debbie Montjean, Walaa Darwiche, Nellie Fotopoulos, Marie-Hélène Godin Pagé, Raouf Fetni, Francis Petrella, Marie-Claire Bélanger, Guillaume Jedraszak, Moncef Benkhalifa, Pierre Miron","doi":"10.1007/s10815-025-03521-6","DOIUrl":"https://doi.org/10.1007/s10815-025-03521-6","url":null,"abstract":"<p><strong>Purpose: </strong>This case report describes a 36-year-old male with primary infertility, associated with a balanced reciprocal translocation between chromosomes 1 and 7. The translocation was initially identified through constitutional karyotyping and further characterized using optical genome mapping (OGM).</p><p><strong>Methods: </strong>Optical genome mapping (OGM) an advanced genomic tool with high-resolution structural variant detection capabilities was used to further characterize the translocation.</p><p><strong>Results: </strong>OGM pinpointed specific breakpoints within the ASB17 gene on chromosome 1 and the INHBA-AS1 gene on chromosome 7, with potential regulatory effects on MSH4 and GLI3, genes involved in meiotic recombination and reproductive development.</p><p><strong>Conclusions: </strong>This report explores the potential roles of these genes in spermatogenesis, discusses chromatin decondensation and interchromosomal effects as additional infertility mechanisms, and underscores the clinical value of OGM in reproductive genetics.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraovarian platelet-rich plasma (PRP) infusion appeared to benefit low prognosis IVF patients; however, when compared to controls, no significant benefit could be confirmed. 卵巢内富血小板血浆(PRP)输注似乎有利于低预后的IVF患者;然而,与对照组相比,没有明显的益处可以证实。
IF 3.2 3区 医学
Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-02 DOI: 10.1007/s10815-025-03530-5
Sarah C Rubin, Kaleb Noruzi, Emily Chen, Alexis Greene, Martin Keltz
{"title":"Intraovarian platelet-rich plasma (PRP) infusion appeared to benefit low prognosis IVF patients; however, when compared to controls, no significant benefit could be confirmed.","authors":"Sarah C Rubin, Kaleb Noruzi, Emily Chen, Alexis Greene, Martin Keltz","doi":"10.1007/s10815-025-03530-5","DOIUrl":"https://doi.org/10.1007/s10815-025-03530-5","url":null,"abstract":"<p><strong>Purpose: </strong>To assess whether in-office intraovarian PRP injections among patients with a history of a low euploid embryo yield following freeze-all PGT-A IVF cycle improves transferable embryo yield when compared to controls.</p><p><strong>Materials and methods: </strong>A retrospective case-control study, between March 2022 and December 2024 where all poor outcome patients who underwent in-office intraovarian PRP injection prior to a repeat freeze-all PGT-A IVF cycle were compared to controls with no intervention between cycles. The primary outcome was transferable embryo yield. Secondary outcomes included: blastocyst yield, aneuploidy rate, and euploid yield.</p><p><strong>Results: </strong>Thirty-two patients met the inclusion criteria and were compared to 309 controls. Mean age for the PRP and control group were 38.3 ± 3.1 and 38.4 ± 3.7 (p = 0.91) respectively. Mean AMH for the PRP group was 1.6 ± 1.1 ng/mL as compared to 1.5 ± 1.0 ng/mL (p = 0.34). Following PRP the blastocyst, euploid and transferable embryo yield increased; however, when compared to controls, there were no differences in IVF outcomes. For patients with an AMH ≥ 1, the euploid yield and transferable embryo yield increased by fivefold; however, there was no difference when compared to the control. For patients with an AMH < 1, there were no differences in euploid or transferable embryo yield following PRP.</p><p><strong>Conclusion: </strong>Although there was an improvement in transferable embryos yielded following PRP, no difference was observed compared to the control group, as the control with a poor initial cycle experienced regression to the mean which may also be a source of bias in the PRP group.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing parental capacity concerns in IVF: the role of child welfare committees-a survey of unit directors. 试管婴儿中管理父母能力的问题:儿童福利委员会的角色——对单位主任的调查。
IF 3.2 3区 医学
Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-02 DOI: 10.1007/s10815-025-03529-y
Avi Tsafrir, Tamar Artom, Raoul Orvieto, Jordana H Hyman, Zivit Worcman, Shlomit Tsafrir
{"title":"Managing parental capacity concerns in IVF: the role of child welfare committees-a survey of unit directors.","authors":"Avi Tsafrir, Tamar Artom, Raoul Orvieto, Jordana H Hyman, Zivit Worcman, Shlomit Tsafrir","doi":"10.1007/s10815-025-03529-y","DOIUrl":"https://doi.org/10.1007/s10815-025-03529-y","url":null,"abstract":"<p><strong>Purpose: </strong>To examine whether Child Welfare Advisory Committees (CWCs) assist IVF unit directors in addressing concerns about prospective parental capacity (PC).</p><p><strong>Methods: </strong>An anonymous online survey of 26 IVF unit directors in Israel was conducted in November 2023, focusing on referrals to CWCs, reasons for referral, and satisfaction with CWC services.</p><p><strong>Results: </strong>Of the 26 directors, 23 responded (88%). Over a 3-year period, 21 (91%) reported referring candidates to CWCs, with referral counts ranging from 1 to \"over 30.\" The most frequently cited concerns were cognitive developmental disability (16 directors, 72%), mental illness (also 16, 72%), and severe physical disability (10, 43%). Thirteen directors (57%) rated CWC availability and quality as reasonable, while five (21%) found services insufficient, and three (13%) reported no access at all. Ten directors (43%) used alternative strategies, including denying treatment without CWC input, referring patients elsewhere, or prolonging the assessment to encourage withdrawal. One in four respondents reported facing legal or administrative challenges following further evaluation requests or treatment refusals.</p><p><strong>Conclusions: </strong>Concerns about prospective PC are relatively uncommon but present in all IVF units. The most frequent concerns relate to cognitive developmental disability, mental illness, and severe physical disabilities. While most directors consult CWCs in such cases, satisfaction with their function is mixed. These findings highlight the need for clearer guidelines and more accessible, consistent consultation structures to support clinicians in managing complex cases.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of low versus high oxygen tension on human oocyte maturation during biphasic capacitation IVM (CAPA-IVM). 低氧与高氧张力对双相容能IVM (CAPA-IVM)中人卵母细胞成熟的影响。
IF 3.2 3区 医学
Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-01 Epub Date: 2025-03-29 DOI: 10.1007/s10815-025-03459-9
Huy H Pham, Viet Q Tran, Anh H Le, Duy L Nguyen, Toan D Pham, Anh L Vu, Tien K Le, Ho L Le, Bao G Huynh, Tuong M Ho, Lan N Vuong
{"title":"Impact of low versus high oxygen tension on human oocyte maturation during biphasic capacitation IVM (CAPA-IVM).","authors":"Huy H Pham, Viet Q Tran, Anh H Le, Duy L Nguyen, Toan D Pham, Anh L Vu, Tien K Le, Ho L Le, Bao G Huynh, Tuong M Ho, Lan N Vuong","doi":"10.1007/s10815-025-03459-9","DOIUrl":"10.1007/s10815-025-03459-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the impact of low versus high oxygen tension on the oocyte maturation rate in biphasic CAPA-IVM.</p><p><strong>Methods: </strong>A sibling oocyte pilot study of cumulus-oocyte complexes (COCs) from participants with polycystic ovary syndrome was performed at an academic IVF center in Vietnam from November 2023 to May 2024. At collection, COCs were allocated to undergo CAPA-IVM culture with low oxygen tension (5%) or high oxygen tension (20%). Culture of COCs took place in two benchtop incubators, each equipped with commercial mix-gas bottles to establish the respective oxygen conditions. The primary outcome was the oocyte maturation rate. Secondary outcomes were rates of two-pronuclei fertilization, day-3 embryos, blastocyst formation, and good-quality embryos.</p><p><strong>Results: </strong>A total of 554 COCs from 20 participants were assigned to the low oxygen (276 COCs) or high oxygen (278 COCs) tension groups. The oocyte maturation rate was significantly lower in the low oxygen tension versus high oxygen tension group (53.6% vs. 65.8%, risk ratio 0.81, 95% confidence interval 0.71-0.94; p=0.004). The two-pronuclei fertilization rate was significantly lower in the low oxygen tension versus high oxygen tension group (61.5% vs. 72.7%, p=0.03). Numbers of day-3 embryos, blastocysts, and good-quality blastocysts were slightly, but not significantly, lower in the low oxygen tension group compared with the high oxygen tension group.</p><p><strong>Conclusions: </strong>Low oxygen tension of 5% during both steps of biphasic CAPA-IVM reduced the number of matured oocytes and 2-pronuclei fertilized oocytes compared with the use of high oxygen tension (20%) during CAPA-IVM.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"1805-1812"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of potential therapeutic targeting in ovarian aging from genetic screening with clinical validation. 通过临床验证的基因筛选确定卵巢衰老的潜在治疗靶点。
IF 3.2 3区 医学
Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-01 Epub Date: 2025-05-09 DOI: 10.1007/s10815-025-03490-w
Xiangfei Wang, Ruolin Mao, Rui Long, Limin Gao, Meng Wang, Juepu Zhou, Kun Qian, Lixia Zhu, Lei Jin
{"title":"Identification of potential therapeutic targeting in ovarian aging from genetic screening with clinical validation.","authors":"Xiangfei Wang, Ruolin Mao, Rui Long, Limin Gao, Meng Wang, Juepu Zhou, Kun Qian, Lixia Zhu, Lei Jin","doi":"10.1007/s10815-025-03490-w","DOIUrl":"10.1007/s10815-025-03490-w","url":null,"abstract":"<p><strong>Purpose: </strong>To screen drug targets of ovarian aging from a genetic perspective.</p><p><strong>Methods: </strong>Systematic analyses were conducted with cis-expression quantitative trait loci data of druggable genes extracted as instrument variables. Summary statistics were from large genome-wide association studies for age at menopause. The following colocalization analysis was utilized to examine whether identified genes and ovarian aging shared causal variants. Furthermore, clinical validation was conducted by comparing expression of identified genes in granulosa cells from women with normal or diminished ovarian reserve (DOR) who went through in vitro fertilization (IVF) and by evaluating correlation of targeted gene expression with ovarian function and IVF outcomes. Moreover, single-nuclear RNA (snRNA) seq and drug database were analyzed to find target cells within the ovary and potential drugs targeting identified genes.</p><p><strong>Results: </strong>Systematic analyses identified five therapeutic targets of ovarian aging, including four protective factors (BRCA1, KLHL18, PNP, SRPK1) and one risk factor (PDIA3). The change in expression level of four protective factors has been verified in clinical validation. Particularly, both BRCA1 and SRPK1 have been downregulated among advanced-aged women with DOR and were positively correlated with anti-Müllerian hormone and antral follicle count. Specific target cells and potential small molecule targeted drugs of these genes were identified through snRNA analysis and searching in the drug database.</p><p><strong>Conclusions: </strong>By systematic genetic analyses combined with clinical validation, we identified five potential druggable genes for ovarian aging, providing theoretical basis and promising direction of therapeutic genetic targets for ovarian aging in the future.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"2039-2052"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report: re-biopsy rescues a to-be-discarded segmental aneuploid embryo resulting in a healthy pregnancy with normal prenatal testing results. 病例报告:重新活检挽救了一个即将被丢弃的节段性非整倍体胚胎,导致健康妊娠,产前检查结果正常。
IF 3.2 3区 医学
Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-01 Epub Date: 2025-05-07 DOI: 10.1007/s10815-025-03494-6
Manuel Viotti, Ketty Margulis, Andrea R Victor, Alex E Murphy, Frank L Barnes, Christo G Zouves
{"title":"Case report: re-biopsy rescues a to-be-discarded segmental aneuploid embryo resulting in a healthy pregnancy with normal prenatal testing results.","authors":"Manuel Viotti, Ketty Margulis, Andrea R Victor, Alex E Murphy, Frank L Barnes, Christo G Zouves","doi":"10.1007/s10815-025-03494-6","DOIUrl":"10.1007/s10815-025-03494-6","url":null,"abstract":"<p><p>This case report describes the strategy for reclassifying embryos initially diagnosed as segmental aneuploid through preimplantation genetic testing for aneuploidy (PGT-A), potentially rescuing those embryos for clinical use. A couple undergoing IVF, facing a lack of viable embryos, opted to re-biopsy a previously tested uniform (non-mosaic) segmental aneuploid embryo. The repeat PGT-A analysis produced a euploid result. Following thorough consultation with a genetic counselor and the treating physician, and after signing an informed consent detailing the associated risks, the couple proceeded with the embryo transfer. The pregnancy was confirmed, and prenatal testing by amniocentesis produced euploid results. This case highlights the potential of re-biopsy to more accurately assess embryos initially diagnosed as segmental aneuploid, helping to avoid the unnecessary discard of viable embryos while minimizing the clinical risks associated with constitutive segmental aneuploidies.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"1827-1831"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of parental age on chromosomal abnormalities in PGT-A embryos: exponentially increasing in the mother and completely null in the father. 父母年龄对PGT-A胚胎染色体异常的影响:母亲呈指数增加,父亲完全没有。
IF 3.2 3区 医学
Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-01 Epub Date: 2025-04-09 DOI: 10.1007/s10815-025-03462-0
Roberto Matorras, Silvia Sierra, Silvia Pérez-Fernández, Iker Malaina, Borja Santos-Zorrozua, Begoña Prieto, Fernando Quintana, Marcos Ferrando, Carmen Rubio, Maitane Gantxegi
{"title":"Influence of parental age on chromosomal abnormalities in PGT-A embryos: exponentially increasing in the mother and completely null in the father.","authors":"Roberto Matorras, Silvia Sierra, Silvia Pérez-Fernández, Iker Malaina, Borja Santos-Zorrozua, Begoña Prieto, Fernando Quintana, Marcos Ferrando, Carmen Rubio, Maitane Gantxegi","doi":"10.1007/s10815-025-03462-0","DOIUrl":"10.1007/s10815-025-03462-0","url":null,"abstract":"<p><strong>Purpose: </strong>To study the influence of parental age on aneuploidy rates (AR) in PGT-A cycles and on the recurrence rate.</p><p><strong>Methods: </strong>A total of 16,029 PGT-A cycles were studied over a 9-year period. The median age was 40.0 [37.0; 41.0] in women and 40.0 [37.0; 43.0] in men. In 48.3%, the biopsy was performed on day 3 embryos (D3E) and in 51.7% on blastocysts (79.5% using NGS).</p><p><strong>Results: </strong>In women, the AR was almost constant at < 50% until the age of 35 but increased steadily to reach > 90% at 44. The AR pattern varied according to embryo stage and was considerably higher in D3E, with a steeper curve. A U-pattern was observed in D3E, whereas this was not seen in blastocysts. In the blastocysts analyzed using NGS, trisomy 21 increased sixfold (from < 1% at < 30 to nearly 5% in women aged 40), whereas trisomies 13 and 18 increased their frequency twofold. After 3 biopsied blastocysts studied using NGS, 100% of women aged ≤ 30 had at least 1 euploid embryo, vs 96% aged 31-35, almost 80% aged 36-40, 50% aged 41-45, and 33% aged 46-50. In terms of the man's age, the non-adjusted analysis revealed a correlation with AR. However, after correcting for the woman's age, no correlation was observed. The man's age was not associated with any of the aneuploidies potentially resulting in a newborn.</p><p><strong>Conclusions: </strong>Carrying out PGT-A systematically in IVF cycles from the age of 38-39 is highly recommended. Advanced paternal age does not carry an increased risk of aneuploidy for the embryo and does not in itself constitute an indication for PGT-A.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"1833-1844"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral GnRH antagonists for ovulation suppression during ovarian stimulation protocols: systemic review and meta-analysis. 口服GnRH拮抗剂在卵巢刺激方案中抑制排卵:系统评价和荟萃分析。
IF 3.2 3区 医学
Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1007/s10815-025-03496-4
Nadav Cohen, Ariel Zilbelicht, Chen Nahshon, Suha Seh, Ofer Lavie, Galia Oron
{"title":"Oral GnRH antagonists for ovulation suppression during ovarian stimulation protocols: systemic review and meta-analysis.","authors":"Nadav Cohen, Ariel Zilbelicht, Chen Nahshon, Suha Seh, Ofer Lavie, Galia Oron","doi":"10.1007/s10815-025-03496-4","DOIUrl":"10.1007/s10815-025-03496-4","url":null,"abstract":"<p><strong>Purpose: </strong>The impact of oral GnRH antagonists on IVF treatment outcomes remains unclear. The aim of the study is to investigate the impact of GnRH antagonist over the outcomes of IVF.</p><p><strong>Methods: </strong>We performed an electronic search using MEDLINE® with the OvidSP interface PUBMED, Embase, Web of Science, and Cochrane Library up to December 16, 2024. We included experimental and non-experimental studies, assessing the role of oral GnRH during controlled ovarian stimulation protocols. Our main outcomes were cycle cancelation rate and mean number of mature oocytes retrieved at oocyte pickup (OPU) day.</p><p><strong>Results: </strong>We included four studies comprising 813 patients, of whom 452 women received oral GnRH antagonists and 294 received injectable subcutaneous GnRH antagonists. No statistical differences were noted in the meta-analysis between each outcome measured (cycle cancelation, mean overall and mature oocytes, fertilization rate, and blastulation rate). Using the GRADE criteria, the overall quality of the existing evidence was determined as moderate.</p><p><strong>Conclusions: </strong>This is the first systemic review and meta-analysis to examine the usage of oral GnRH antagonists for ovulation suppression during IVF treatments. Our findings suggest the use of oral GnRH antagonists may be beneficial in infertility treatments; however, caution should be taken, as robust establishment of their effectivity and safety in clinical practice is still pending.</p><p><strong>Trial registration: </strong>Registration Number: PROSPERO study ID: CRD42024599730.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"1773-1779"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A cautionary tale from contemporary ARTs: transitioning from bench to bedside with celerity! 当代艺术的警世故事:从长凳快速过渡到床边!
IF 3.2 3区 医学
Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-01 DOI: 10.1007/s10815-025-03569-4
David F Albertini
{"title":"A cautionary tale from contemporary ARTs: transitioning from bench to bedside with celerity!","authors":"David F Albertini","doi":"10.1007/s10815-025-03569-4","DOIUrl":"10.1007/s10815-025-03569-4","url":null,"abstract":"","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":"1741-1742"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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