Qiaomei Zheng, Jie Li, Shaozhan Chen, Jinhua Wang, Lihong Chen
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Similarly, the number of oocytes retrieved, the number of D3 high quality embryos, and the number of available embryos were fewer in endometriosis group (P < 0.05). However, total number of available embryos, clinical pregnancy rates per transfer cycle, live birth rates per transfer cycle, and cumulative birth rate were found to be similar in both groups (P > 0.05). The presence of POR was found to have no significant impact on the cumulative live birth rate among patients with endometriosis.</p><p><strong>Conclusions: </strong>While linked to fewer oocytes per cycle, POR does not predict poorer IVF/ICSI-ET outcomes in endometriosis patients. Patient age, not POR or endometriosis itself, is the primary determinant of live birth success. This study challenges the conventional emphasis on oocyte quantity, advocating for a paradigm shift toward individualized, quality-focused ART strategies in endometriosis-related infertility.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Beyond oocyte quantity: the paradoxical role of poor ovarian response in live birth outcomes among endometriosis patients undergoing IVF/ICSI-ET.\",\"authors\":\"Qiaomei Zheng, Jie Li, Shaozhan Chen, Jinhua Wang, Lihong Chen\",\"doi\":\"10.1007/s10815-025-03661-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate the impact of poor ovarian response (POR) on live birth outcomes in endometriosis patients undergoing IVF/ICSI-ET, despite the expected association between reduced oocyte yield and poorer prognosis.</p><p><strong>Methods: </strong>Patients were divided into two groups as endometriosis group (n = 55) and tubal factor group (n = 107). 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引用次数: 0
摘要
目的：评估卵巢反应差（POR）对接受IVF/ICSI-ET的子宫内膜异位症患者活产结局的影响，尽管预期卵母细胞数量减少与预后较差存在关联。方法：将患者分为子宫内膜异位症组（55例）和输卵管因子组（107例）。主要结局包括临床妊娠率、每个胚胎移植周期的活产率和累计活产率。次要结局是控制卵巢过度刺激（COH）结果和胚胎参数。结果：子宫内膜异位症组POR发生率明显升高（18.9% vs. 5.60%, P < 0.05）。发现POR的存在对子宫内膜异位症患者的累计活产率没有显著影响。结论：虽然与每个周期卵母细胞较少有关，但POR并不能预测子宫内膜异位症患者较差的IVF/ICSI-ET结果。患者的年龄，而不是贫穷或子宫内膜异位症本身，是活产成功的主要决定因素。本研究挑战了对卵母细胞数量的传统重视，倡导在子宫内膜异位症相关不孕症中转向个体化、以质量为中心的ART策略。
Beyond oocyte quantity: the paradoxical role of poor ovarian response in live birth outcomes among endometriosis patients undergoing IVF/ICSI-ET.
Purpose: To evaluate the impact of poor ovarian response (POR) on live birth outcomes in endometriosis patients undergoing IVF/ICSI-ET, despite the expected association between reduced oocyte yield and poorer prognosis.
Methods: Patients were divided into two groups as endometriosis group (n = 55) and tubal factor group (n = 107). The primary outcomes included clinical pregnancy rate, live birth rate per embryo transfer cycle, and cumulative live birth rate. Secondary outcomes were controlled ovarian hyperstimulation (COH) results and embryo parameters.
Results: The incidence rate of POR increased significantly in endometriosis group (18.9% vs. 5.60%, P < 0.05). Similarly, the number of oocytes retrieved, the number of D3 high quality embryos, and the number of available embryos were fewer in endometriosis group (P < 0.05). However, total number of available embryos, clinical pregnancy rates per transfer cycle, live birth rates per transfer cycle, and cumulative birth rate were found to be similar in both groups (P > 0.05). The presence of POR was found to have no significant impact on the cumulative live birth rate among patients with endometriosis.
Conclusions: While linked to fewer oocytes per cycle, POR does not predict poorer IVF/ICSI-ET outcomes in endometriosis patients. Patient age, not POR or endometriosis itself, is the primary determinant of live birth success. This study challenges the conventional emphasis on oocyte quantity, advocating for a paradigm shift toward individualized, quality-focused ART strategies in endometriosis-related infertility.
期刊介绍：
The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species.
The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.
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