Journal of Biomaterials Science, Polymer Edition最新文献

{"title":"Nanostructured Ox-MWCNT-PPy-Au electrochemical sensor for ultralow detection of retrorsine and evaluation of its cytotoxic effects on liver cells.","authors":"Ezgi Zekiye Akturk, Muath Njjar, Melek Tunc Ata, Ahmet Kaya, Abdullah Akdogan, Canan Onac","doi":"10.1080/09205063.2025.2529535","DOIUrl":"https://doi.org/10.1080/09205063.2025.2529535","url":null,"abstract":"<p><p>This study presents the development of a novel retrorsine (RTS)-imprinted sensor utilizing oxidized multi-walled carbon nanotubes (Ox-MWCNTs), polypyrrole (PPy), and gold nanoparticles (AuNPs), employing square wave voltammetry for the sensitive and selective detection of RTS which causes oxidative-stress and DNA damage. The fabricated Ox-MWCNT-PPy-AuNP sensor demonstrated a surface-area of (0.218 cm²) is 4.25 times larger than a bare glassy carbon electrode, with a low charge transfer resistance (10.9 Ω), enhancing electron transfer kinetics. The sensor showed excellent sensitivity in detecting retrorsine, with a limit of detection of 0.035 nM in synthetic matrices and -0.030 nM in HepaRG cell culture medium. Toxicity assays in HepaRG cells revealed dose-dependent oxidative-stress, with glutathione levels decreasing from 23.08 ± 0.21 µmol/10⁹ to 21.21 ± 0.02 µmol/10⁹ at 35 µM retrorsine. Concurrently, GSSG levels increased from 1.32 ± 0.26 µmol/10⁹ to 2.22 ± 0.02 µmol/10⁹. DNA-damage assessed <i>via</i> comet assay, showed significant increases in tail-moment (2.53 µm) and tail-migration (16.13 µm). Oxidative DNA-damage, indicated by 8-OHdG levels, increased significantly from 0.29 ± 0.02 ng.mL^- (control) to 0.47 ± 0.07 ng.mL^- at 35 µM retrorsine. These findings demonstrate the sensor's effectiveness for retrorsine detection and its applicability in toxicological studies. The integration of nanomaterial engineering and molecular imprinting provides a highly sensitive, selective, and eco-friendly solution for monitoring toxic agents and assessing their biological impacts.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-31"},"PeriodicalIF":3.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral sustained release expandable dosage forms: innovations, challenges, and future directions.","authors":"Phool Chandra, Sani Pratap Singh, Vaibhav Rastogi, Mayur Porwal, Neetu Sachan","doi":"10.1080/09205063.2025.2528935","DOIUrl":"https://doi.org/10.1080/09205063.2025.2528935","url":null,"abstract":"<p><p>Oral sustained-release dosage forms have gained considerable attention for their ability to enhance therapeutic outcomes and improve patient compliance. Among these, expandable drug delivery systems represent a significant innovation, offering extended gastric retention and controlled drug release through size-based retention strategies. These systems expand in the stomach after administration, delaying gastric emptying and enabling prolonged drug action. This review presents a consolidated overview of key expandable mechanisms-such as swelling, unfolding, floating, and mucoadhesion-along with a detailed discussion on formulation strategies, polymeric materials, and <i>in vivo</i> behavior. Special emphasis is placed on recent advancements in smart polymers, 3D printing, and novel fabrication techniques. The review also explores clinical applications, manufacturing challenges, safety concerns, and future research directions. By integrating scientific, technical, and translational insights, this paper aims to highlight the potential of expandable dosage forms in advancing oral drug delivery technologies.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-30"},"PeriodicalIF":3.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Janus-loaded Zn²⁺ composite film dressing based on chitin from <i>Periplaneta americana</i> effectively promotes wound healing.","authors":"Yang Qing, Ailian Zhu, Ling He, Hujing Zhang, Xi Wang, Chunyan Xiao, Qiang Fu, Qin Song","doi":"10.1080/09205063.2025.2524871","DOIUrl":"https://doi.org/10.1080/09205063.2025.2524871","url":null,"abstract":"<p><p>This study compared the application-specific benefits of PAC (<i>Periplaneta americana</i> chitin) and SC (Shrimp chitin) blended with PEG (Polyethylene Glycol) in innovative wound-dressing materials. By preparing SC/PEG and PAC/PEG porous blended membranes, it was found that PAC/PEG has better breathability, degradability. Based on this, we developed a Janus PAC/PEG@Zn0.3 composite film dressing for wound healing. After crosslinking PAC with PEG, a hydrophilic layer was formed through phase separation and selective dissolution, loaded with Zn²⁺, and combined with a hydrophobic PCL (Polycaprolactone) membrane using a simple coating technique. This composite film has the characteristics of being moist, breathable, and stretchable, and exhibits good biodegradability and compatibility. The addition of Zn²⁺ enhanced the hemostatic and antibacterial properties of the film. The mouse wound healing experiment showed that the dressing promoted collagen deposition and capillary generation, accelerating wound healing. Overall, the Janus PAC/PEG@Zn0.3 composite film is a wound dressing with promising application prospects.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-29"},"PeriodicalIF":3.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual drug delivery of Paclitaxel and Curcumin via hyaluronic acid functionalized nanoparticles for improved breast cancer therapy.","authors":"Joyceline Praveena, Yuvraj Rallapalli, Keerthana Suresh Kizhakkanoodan, Divakarareddy Vemanna Paladugulu, Sriprasad Acharya, Bharath Raja Guru","doi":"10.1080/09205063.2025.2525668","DOIUrl":"https://doi.org/10.1080/09205063.2025.2525668","url":null,"abstract":"<p><p>Breast cancer has high mortality rate among women. Though paclitaxel is one of the important drugs used, but frequent use will lead to drug resistance. Nuclear factor kappa B (NFƘB) a transcription factor will be up regulated with frequent use of paclitaxel, and this increases drug resistance in cancer cells. Usage of curcumin will down regulate the NFƘB and using both the drugs in combination with different mechanisms of action has shown synergistic effects and reduces NFƘB expression in cancer cells. To reduce the systemic toxicity, low intracellular uptake and low bioavailability, nano-based therapeutics were used. To improve the targeting ability of the drug to the cancer cells, Hyaluronic acid (HA) is used as a targeting moiety on the surface of the nanoparticles (NP). The study focuses on formulating a Hyaluronic acid (HA) surface functionalized Poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) encapsulated with Paclitaxel (PTX) or Curcumin (CUR) to target CD44v expressed on breast cancer cells. HA surface functionalized NPs encapsulated with only PTX or in combination with CUR were treated against MCF-7 breast cancer cells. We found that HA surface functionalized NPs with combination of PTX and CUR has substantially increased cytotoxicity compared to non-surface functionalized NPs and free drugs and 2.5-fold increased cellular uptake of NPs compared to free drugs. We also found that NFKB activity reduces significantly with the use of CUR with PTX. From the results, we can conclude that combination of drugs in HA surface functionalized NPs will be useful for breast cancer therapy.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-polyplexes from a cationic modification of poly(γ-glutamic acid).","authors":"Porochista Dorost, Montserrat García-Alvarez, Antxon Martínez de Ilarduya","doi":"10.1080/09205063.2025.2527221","DOIUrl":"https://doi.org/10.1080/09205063.2025.2527221","url":null,"abstract":"<p><p>In this study, a cationic biopolymer has been developed through the chemical modification of a biodegradable and biocompatible polymer such as poly(γ-glutamic acid) (PGGAH). A series of PGGAH_xTMEA_y copolymers with varying degrees of cationic groups incorporation (11-95%) were synthesized by partial esterification of carboxylate side groups of PGGAH with 2-bromoethyl trimethylammonium bromide (BrETABr). The copolymers were thoroughly characterized using ¹H NMR, FTIR, TGA, and GPC analyses. It was found that the degree of esterification had a pronounced effect on the thermal stability, and DNA-binding capacity of the copolymers. Higher degrees of modification were shown to enhance the excellent potential for DNA complexation, forming polyplex nanoaggregates with sizes in the range of 80-220 nm at various ammonium-to-phosphate (N/P) ratios. The stability, size, and surface charge of these polyplexes were monitored over two weeks in aqueous solutions using dynamic light scattering (DLS). Enhanced stability in polyplex formation was exhibited by copolymers with higher degrees of modification, which maintained consistent particle sizes across different N/P ratios. This study provides valuable insights into the development of efficient DNA delivery systems based on a new cationically modified poly(γ-glutamic acid) derivative.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-15"},"PeriodicalIF":3.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in conducting tissue engineering based on conducting polymers.","authors":"Büşra Oktay, Haya Akkad, Esma Ahlatcıoğlu Özerol","doi":"10.1080/09205063.2025.2527910","DOIUrl":"https://doi.org/10.1080/09205063.2025.2527910","url":null,"abstract":"<p><p>Conductive tissue engineering has emerged as a revolutionary approach to addressing the limitations of traditional regenerative therapies by integrating electrical and mechanical properties into biomaterials. This field focuses on mimicking the natural microenvironment of excitable tissues, such as nerves, cardiac, and skeletal muscles, to enhance cellular functions and facilitate tissue repair. Conducting polymers (CP), including polypyrrole, polyaniline, and PEDOT, have been widely utilized for their exceptional electrical conductivity, biocompatibility, and tunable properties. The incorporation of these polymers into electroactive scaffolds has demonstrated significant potential in promoting cell proliferation, differentiation, and alignment, while also enabling functional recovery through electrical stimulation. Applications in nerve regeneration have shown promise in restoring synaptic connections, while in cardiac and skeletal muscle tissues, conductive scaffolds aid in synchronized contractions and structural reinforcement. Despite these advancements, challenges such as optimizing conductivity, achieving long-term biocompatibility, and scaling production remain key areas of focus. This review thoroughly examines the use of conducting polymers for different tissue types such as neural, cardiac, and muscular tissues in light of the most recent literature. By addressing key topics such as electrical stimulation, multifunctional scaffold systems, biological responses, and emerging research trends, this study presents a holistic and up-to-date contribution to the field. Future directions aim to refine scaffold designs, enhance electrical stimulation protocols, and explore translational potential, paving the way for advanced regenerative therapies.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-33"},"PeriodicalIF":3.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyaluronic acid and K-carrageenan metal ionic cross-linked polymers: a promising injectable hydrogels for prolonged chemotherapeutic drug delivery.","authors":"Hadeia Mashaqbeh, Rania Hamed, Rana Obaidat, Ali Hmedat, Raffa Aburayya, Sara Hijazi, Yazan Akkam","doi":"10.1080/09205063.2025.2524059","DOIUrl":"https://doi.org/10.1080/09205063.2025.2524059","url":null,"abstract":"<p><p>Hydrogel-based drug delivery technologies have garnered considerable interest in the biomedical field, aiming to overcome the challenges associated with conventional treatments. This investigation reports a novel injectable hydrogel composed of non-chemically modified hyaluronic acid and κ-carrageenan, crosslinked using a Fe(III)-ethylenediaminetetraacetic acid (EDTA) complex for the delivery of a chemotherapeutic agent. The system exhibits shear-thinning behavior, possessing both appropriate rheological and drug-release properties, thereby eliminating the need for chemical or thermoresponsive additives. This study examines this system in the context of chemotherapeutic delivery, providing a novel approach to achieving biocompatibility, structural flexibility, injectability, and prolonged release properties. The developed hydrogels were evaluated <i>in vitro</i> for their ability to deliver the model drug daunorubicin (DNR). Physicochemical characterizations of hydrogels, including FTIR, DSC, and SEM analysis, were carried out. Furthermore, the rheological properties, <i>in vitro</i> release, swelling, degradation, and cytotoxicity of the developed hydrogels were evaluated. Homopolymer hydrogels of metal ion crosslinked HA, KCG, and hybrid hydrogels of HA-KCG were developed and evaluated. All studied hydrogels can control DNR release; compared to homopolymer hydrogels, the HA-KCG hybrid hydrogels showed a better swelling ratio, a slower degradation rate, and a higher capability to prolong DNR release over 16 days. In addition, the evaluated hydrogels exhibit shear-thinning properties and diverse viscoelastic properties, as well as enhanced DNR cytotoxic activities. Overall, Injectable self-healing hydrogels of HA and KCG interpenetrating polymer networks (IPNs) produced by metal ionic crosslinking were successfully created, exhibiting shear-thinning ability and thixotropic properties, making them a potential candidate for localized chemotherapeutic drug delivery.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-30"},"PeriodicalIF":3.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma mediated immobilization of metformin on polyethylene: effects on drug release, antibacterial activity, and biocompatibility.","authors":"Štěpán Žídek, Kateřina Štěpánková, Hana Pištěková, Milan Masař, Monika Stupavská, Pavel Sťahel, David Trunec, Miran Mozetič, Pavel Valasek, Marian Lehocky","doi":"10.1080/09205063.2025.2524261","DOIUrl":"https://doi.org/10.1080/09205063.2025.2524261","url":null,"abstract":"<p><p>Metformin, a widely used antidiabetic drug, has gained attention for its potential applications in antimicrobial surfaces, delivery systems, and anticancer therapy. However, immobilizing metformin in a stable, bioactive, and dose-controllable manner onto a chemically inert, hydrophobic surface is challenging. The objective of this study is to immobilize metformin at various concentration (0.5, 1, 2, 5, 10, and 20 g·L^-1) onto low-density polyethylene (LDPE) surfaces by a multistep approach with the aim of creating bioactive coatings. In this approach, LDPE was first treated with a 40 kHz low pressure plasma discharge in air atmosphere, followed by non-covalent attachment of acrylic acid <i>via</i> a grafting technique. Metformin was covalently attached to the surface <i>via</i> N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) and <i>N</i>-Hydroxysuccinimide (NHS) activation, while its presence on the polymer surface was confirmed by Water contact angle (WCA), Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). Sustained metformin release with a shift from Fickian to first-order kinetics was observed at higher drug loading. Antibacterial testing against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> showed no antibacterial effect at the selected concentration levels. Cytocompatibility assays with multipotent mesenchymal cells showed good biocompatibility of modified surfaces, with only dose-dependent cytotoxicity at higher metformin concentrations (>5 g·L^-1). These results demonstrate that despite the absence of antibacterial effects, the developed system offers a promising platform for further biomedical applications requiring controlled drug surface functionalization and retained cytocompatibility.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D bioprinting hydrogel models of neurovascular unit for in vitro diabetic peripheral neuropathy study.","authors":"Yanping Guo, Runze Tian, Zerui Chen, Yuhong Wang, Changjiang Yu, Nanbo Liu, Tucheng Sun, Shuoji Zhu, Tingting Liu, Bin Yao, Ping Zhu","doi":"10.1080/09205063.2025.2524056","DOIUrl":"https://doi.org/10.1080/09205063.2025.2524056","url":null,"abstract":"<p><p>Diabetic peripheral neuropathy (DPN), a prevalent complication of diabetes, caused a significant morbidity and posed a heavy burden on society. Considering the lack of disease models <i>in vitro</i> for DPN and the advantages of 3D bioprinting in disease modeling, we employed 3D bioprinting technology based on GelMA hydrogel to construct neurovascular units to mimic peripheral nerves and vessels <i>in vitro</i>, further we built the pathological microenvironment characteristic of DPN when the treatment of high glucose in these units. Our 3D disease models closely recapitulated <i>in vivo</i> pathological conditions, including oxidative stress and inflammatory responses, which are key hallmarks of DPN. Then we explored the effects of cholesterol on DPN progression using our disease models <i>in vitro</i>. Moreover, the results of RNA-seq analysis revealed that cholesterol stimulation promoted neuron death and inhibited angiogenesis, thereby accelerating the progression of DPN. We identified <i>Fos</i> as a potential therapeutic target, given its role in regulating reactive oxygen species (ROS), neuron death, and transcriptional activity. This study provides valuable insights into the molecular mechanisms underlying the interaction between cholesterol and DPN, and highlights the potential for targeting cholesterol metabolism in the treatment of DPN.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene expression and hormonal signaling in osteoporosis: from molecular mechanisms to clinical breakthroughs.","authors":"Gurinderdeep Singh, Ronald Darwin, Krishna Chandra Panda, Shaikh Amir Afzal, Shashwat Katiyar, Ram C Dhakar, Sangeetha Mani","doi":"10.1080/09205063.2024.2445376","DOIUrl":"10.1080/09205063.2024.2445376","url":null,"abstract":"<p><p>Osteoporosis is well noted to be a universal ailment that realization impaired bone mass and micro architectural deterioration thus enhancing the probability of fracture. Despite its high incidence, its management remains highly demanding because of the multifactorial pathophysiology of the disease. This review highlights recent findings in the management of osteoporosis particularly, gene expression and hormonal control. Some of the newest approaches regarding the subject are described, including single-cell RNA sequencing and long non-coding RNAs. Also, the review reflects new findings on hormonal signaling and estrogen and parathyroid hormone; patient-specific approaches due to genetic and hormonal variation. Potential new biomarkers and AI comprised as factors for improving the ability to anticipate and manage fractures. These hold great potential of new drugs, combination therapies and gene based therapies for osteoporosis in the future. Further studies and cooperation of scientists and clinicians will help to apply such novelties into practical uses in the sphere of medicine in order to enhance the treatment of patients with osteoporosis.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1466-1501"},"PeriodicalIF":3.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}