Journal of Biomaterials Science, Polymer Edition最新文献_第2页

ROS-Responsive Nanoparticles with Antioxidative Effect for the treatment of Diabetic Retinopathy. 用于治疗糖尿病视网膜病变的具有抗氧化作用的 ROS 反应性纳米粒子。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-24 DOI: 10.1080/09205063.2024.2406628

Jinjin Li, Yujia Liu, Kedui Geng, Xin Lu, Xiangchun Shen, Qianqian Guo

{"title":"ROS-Responsive Nanoparticles with Antioxidative Effect for the treatment of Diabetic Retinopathy.","authors":"Jinjin Li, Yujia Liu, Kedui Geng, Xin Lu, Xiangchun Shen, Qianqian Guo","doi":"10.1080/09205063.2024.2406628","DOIUrl":"https://doi.org/10.1080/09205063.2024.2406628","url":null,"abstract":"Diabetic retinopathy (DR) is a common microvascular complication of diabetes necessitating early intervention to impede progression, despite current clinical treatments focusing on advanced stages. Essential oils from Fructus Alpiniae zerumbet (EOFAZ) have demonstrated efficacy in protecting against high glucose (HG)-induced Müller cell activation and DR development. This study introduced a reactive oxidative species (ROS)-responsive drug delivery system (NPSPHE@EOFAZ) targeting early DR stages and oxidative stress. Our engineered nanoparticles effectively deliver EOFAZ into HG-exposed Müller cells by detecting and responding to elevated oxidative stress levels. The NPSPHE@EOFAZ significantly inhibited abnormal cell growth, reduced oxidative stress, and alleviated inflammation in vitro. In vivo experiments on diabetic mice with DR revealed that NPSPHE@EOFAZ mitigated early pathological changes by reducing oxidative stress and inflammation while also alleviating organ damage in the heart, liver, spleen, lung, and kidney. These findings underscore the potential of NPSPHE@EOFAZ as a promising antioxidant for early intervention in DR pathogenesis.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil membrane-coated multifunctional biomimetic nanoparticles for spinal cord injuries. 用于脊髓损伤的中性粒细胞膜包被多功能仿生纳米粒子。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-19 DOI: 10.1080/09205063.2024.2404760

Hongyi Zhu, Feng Cai, Ziang Li, Lichen Zhang, Xindie Zhou, Jiapei Yao, Wei Wang, Liang Zhou, Xinzhao Jiang, Kun Xi, Yong Gu, Liang Chen, Yidi Zhou

{"title":"Neutrophil membrane-coated multifunctional biomimetic nanoparticles for spinal cord injuries.","authors":"Hongyi Zhu, Feng Cai, Ziang Li, Lichen Zhang, Xindie Zhou, Jiapei Yao, Wei Wang, Liang Zhou, Xinzhao Jiang, Kun Xi, Yong Gu, Liang Chen, Yidi Zhou","doi":"10.1080/09205063.2024.2404760","DOIUrl":"https://doi.org/10.1080/09205063.2024.2404760","url":null,"abstract":"Spinal cord injury (SCI) is one of the most complex diseases. After SCI, severe secondary injuries can cause intense inflammatory storms and oxidative stress responses, leading to extensive neuronal apoptosis. Effective regulation of inflammation and oxidative stress after SCI remains an unresolved challenge. In this study, resveratrol-loaded nanoparticles coated with neutrophil membranes (NMR) were prepared using the emulsion-solvent evaporation method and membrane encapsulation technology. Multifunctional biomimetic nanoparticles retain neutrophil membrane-related receptors and possess a strong adsorption capacity for inflammatory factors. As a drug carrier, NMR can sustainably release resveratrol for >72 h. Moreover, co-culture studies in vitro show that the NMR help regulate macrophage polarization to relieve inflammatory response, reduce intracellular reactive oxygen species by approximately 50%, and improve mitochondrial membrane potential to alleviate oxidative stress. After injecting NMR into the injury site, it reduces early apoptosis, inhibit scar formation, and promote neural network recovery to improve motor function. This study demonstrates the anti-inflammatory, antioxidant, and neuroprotective effects of NMR, thus providing a novel therapeutic strategy for SCI.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-layer nanofibrous PCL/gelatin membrane as a sealant barrier to prevent postoperative pancreatic leakage. 双层纳米纤维 PCL/明胶膜作为密封屏障，防止术后胰腺渗漏。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-18 DOI: 10.1080/09205063.2024.2402135

Prayas Chakma Shanto,Heyjin Tae,Md Yousuf Ali,Nusrat Jahan,Hae Il Jung,Byong-Taek Lee

{"title":"Dual-layer nanofibrous PCL/gelatin membrane as a sealant barrier to prevent postoperative pancreatic leakage.","authors":"Prayas Chakma Shanto,Heyjin Tae,Md Yousuf Ali,Nusrat Jahan,Hae Il Jung,Byong-Taek Lee","doi":"10.1080/09205063.2024.2402135","DOIUrl":"https://doi.org/10.1080/09205063.2024.2402135","url":null,"abstract":"Post-operative pancreatic leakage is a severe surgical complication that can cause internal bleeding, infections, multiple organ damage, and even death. To prevent pancreatic leakage and enhance the protection of the suture lining and tissue regeneration, a dual-layer nanofibrous membrane composed of synthetic polymer polycaprolactone (PCL) and biopolymer gelatin was developed. The fabrication of this dual-layer (PGI-PGO) membrane was achieved through the electrospinning technique, with the inner layer (PGI) containing 2% PCL (w/v) and 10% gelatin (w/v), and the outer layer (PGO) containing 10% PCL (w/v) and 10% gelatin (w/v) in mixing ratios of 2:1 and 1:1, respectively. Experimental results indicated that a higher gelatin content reduced fiber diameter enhanced the hydrophilicity of the PGI layer compared to the PGO layer, improved the membrane's biodegradability, and increased its adhesive properties. In vitro biocompatibility assessments with L929 fibroblast cells showed enhanced cell proliferation in the PGI-PGO membrane. In vivo studies confirmed that the PGI-PGO membrane effectively protected the suture line without any instances of leakage and promoted wound healing within four weeks post-surgery. In conclusion, the nanofibrous PGI-PGO membrane demonstrates a promising therapeutic potential to prevent postoperative pancreatic leakage.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emerging role of nanoscaffolds in chronic diabetic wound healing: a new horizon for advanced therapeutics 纳米支架在慢性糖尿病伤口愈合中的新兴作用：先进疗法的新视野

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-18 DOI: 10.1080/09205063.2024.2402148

Mehmet Ali Tibatan, Dzana Katana, Casey M. Yin

引用次数: 0

Triple-layered encapsulation of sensitive biomolecules into poly (ε-caprolactone) nanofibers using AC electrospraying. 利用交流电喷雾技术将敏感生物分子三层封装到聚（ε-己内酯）纳米纤维中。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-12 DOI: 10.1080/09205063.2024.2399387

Nikifor Asatiani,Petra Křtěnová,Pavel Šimon,Štěpán Kunc,Petr Mikeš

{"title":"Triple-layered encapsulation of sensitive biomolecules into poly (ε-caprolactone) nanofibers using AC electrospraying.","authors":"Nikifor Asatiani,Petra Křtěnová,Pavel Šimon,Štěpán Kunc,Petr Mikeš","doi":"10.1080/09205063.2024.2399387","DOIUrl":"https://doi.org/10.1080/09205063.2024.2399387","url":null,"abstract":"The incorporation of sensitive bioactive substances such as proteins or DNA into nanofibers poses a significant problem due to the toxicity of most organic solvents. The main idea of this study is to use alternating current electrospraying to create a suspension consisting of polyvinyl alcohol (PVA) capsules containing a bioactive substance dispersed in a solvent system suitable for a water-insoluble biocompatible polymer. In this suspension consisting of PVA capsules and a chloroform/ethanol mixture, poly (ε-caprolactone) (PCL) was dissolved and spun by needle-free electrospinning. The result is a fibrous PCL structure in which PVA capsules containing the bioactive agent are integrated. The PVA capsules protect the bioactive substance from the organic solvents needed to dissolve the PCL. To verify the efficacy of the capsules' protection against chloroform, the green fluorescent protein was first encapsulated into the nanofibers, followed by horseradish peroxidase. Both molecules were shown to retain their bioactivity within the nanofibers.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of poly(vinyl pyrrolidone) and poly(ethylene glycol) microneedle arrays for delivering glycosaminoglycan, chondroitin sulfate, and hyaluronic acid 设计用于输送糖胺聚糖、硫酸软骨素和透明质酸的聚乙烯吡咯烷酮和聚乙二醇微针阵列

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-12 DOI: 10.1080/09205063.2024.2392914

Andisheh Choupani, Elif Sevval Temucin, Eda Ciftci, Feray Bakan, Busra Tugba Camic, Guralp Ozkoc, Meltem Sezen, Petek Korkusuz, Feza Korkusuz, Bekir Bediz

引用次数: 0

Robust tissue adhesion in biomedical applications: enhancing polymer stability in an injectable protein-based hydrogel. 生物医学应用中稳健的组织粘附性：增强可注射蛋白质水凝胶中聚合物的稳定性。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-11 DOI: 10.1080/09205063.2024.2398888

Pijush Giri,Daman Yadav,Balaram Mishra,Mukesh Kumar Gupta,Devendra Verma

{"title":"Robust tissue adhesion in biomedical applications: enhancing polymer stability in an injectable protein-based hydrogel.","authors":"Pijush Giri,Daman Yadav,Balaram Mishra,Mukesh Kumar Gupta,Devendra Verma","doi":"10.1080/09205063.2024.2398888","DOIUrl":"https://doi.org/10.1080/09205063.2024.2398888","url":null,"abstract":"Protein-based hydrogels are appealing materials for a variety of therapeutic uses because they are compatible, biodegradable, and adaptable to biological and chemical changes. Therefore, adherent varieties of hydrogels have received significant study; nevertheless, the majority of them show weak mechanical characteristics, transient adherence, poor biocompatibility activity, and low tensile strength. Here we are reporting, a two-component (BSA-gelatin) protein solution crosslinked with Tetrakis (hydroxymethyl) phosphonium chloride (THPC) to form a novel hydrogel. Compared with classical adhesive hydrogels, this hydrogel showed enhanced mechanical properties, was biocompatible with L929 cells, and had minimal invasive injectability. A considerable, high tensile strength of 73.33 ± 11.54 KPa and faultless compressive mechanical properties of 173 KPa at 75% strain were both demonstrated by this adhesive hydrogel. Moreover, this maximum tissue adhesion strength could reach 18.29 ± 2.22 kPa, significantly higher than fibrin glue. Cell viability was 97.09 ± 6.07%, which indicated that these hydrogels were non-toxic to L929. The fastest gelation time of the BSA-gelatin hydrogel was 1.25 ± 0.17 min at physiological pH and 37 °C. Therefore, the obtained novel work can potentially serve as a tissue adhesive hydrogel in the field of biomedical industries.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterial-functionalized electrospun scaffolds for tissue engineering. 用于组织工程的纳米材料功能化电纺支架。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-11 DOI: 10.1080/09205063.2024.2399909

Kilole Tesfaye Chaka,Kai Cao,Tamrat Tesfaye,Xiaohong Qin

{"title":"Nanomaterial-functionalized electrospun scaffolds for tissue engineering.","authors":"Kilole Tesfaye Chaka,Kai Cao,Tamrat Tesfaye,Xiaohong Qin","doi":"10.1080/09205063.2024.2399909","DOIUrl":"https://doi.org/10.1080/09205063.2024.2399909","url":null,"abstract":"Tissue engineering has emerged as a biological alternative aimed at sustaining, rehabilitating, or enhancing the functionality of tissues that have experienced partial or complete loss of their operational capabilities. The distinctive characteristics of electrospun nanofibrous structures, such as their elevated surface-area-to-volume ratio, specific pore sizes, and fine fiber diameters, make them suitable as effective scaffolds in tissue engineering, capable of mimicking the functions of the targeted tissue. However, electrospun nanofibers, whether derived from natural or synthetic polymers or their combinations, often fall short of replicating the multifunctional attributes of the extracellular matrix (ECM). To address this, nanomaterials (NMs) are integrated into the electrospun polymeric matrix through various functionalization techniques to enhance their multifunctional properties. Incorporation of NMs into electrospun nanofibrous scaffolds imparts unique features, including a high surface area, superior mechanical properties, compositional variety, structural adaptability, exceptional porosity, and enhanced capabilities for promoting cell migration and proliferation. This review provides a comprehensive overview of the various types of NMs, the methodologies used for their integration into electrospun nanofibrous scaffolds, and the recent advancements in NM-functionalized electrospun nanofibrous scaffolds aimed at regenerating bone, cardiac, cartilage, nerve, and vascular tissues. Moreover, the main challenges, limitations, and prospects in electrospun nanofibrous scaffolds are elaborated.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of bio-based polymeric blends - a comprehensive review. 生物基聚合物混合物的开发--综述。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-09 DOI: 10.1080/09205063.2024.2394300

Jaya Maitra,Nikita Bhardwaj

{"title":"Development of bio-based polymeric blends - a comprehensive review.","authors":"Jaya Maitra,Nikita Bhardwaj","doi":"10.1080/09205063.2024.2394300","DOIUrl":"https://doi.org/10.1080/09205063.2024.2394300","url":null,"abstract":"The current impetus to develop bio-based polymers for greater sustainability and lower carbon footprint is necessitated due to the alarming depletion of fossil resources, concurrent global warming, and related environmental issues. This article reviews the development of polymeric blends based on bio-based polymers. The focus on bio-based polymers is due to their greater 'Sustainability factor' as they are derived from renewable resources. The article delves into the synthesis of both conventional and highly biodegradable bio-based polymers, each crafted from feedstocks derived from nature's bounty. What sets this work apart is the exploration of blending existing bio-based polymers, culminating in the birth of entirely new materials. This review provides a comprehensive overview of the recent advancements in the development of bio-based polymeric blends, covering their synthesis, properties, applications, and potential contributions to a more sustainable future. Despite their potential benefits, bio-based materials face obstacles such as miscibility, processability issues and disparities in physical properties compared to conventional counterparts. The paper also discusses significance of compatibilizers, additives and future directions for the further advancement of these bio-based blends. While bio-based polymer blends hold promise for environmentally benign applications, many are still in the research phase. Ongoing research and technological innovations are driving the evolution of these blends as viable alternatives, but continued efforts are needed to ensure their successful integration into mainstream industrial practices. Concerted efforts from both researchers and industry stakeholders are essential to realize the full potential of bio-based polymers and accelerate their adoption on a global scale.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current strategic arsenal and advances in nose to brain nanotheranostics for therapeutic intervention of glioblastoma multiforme. 目前用于治疗多形性胶质母细胞瘤的鼻脑纳米otheranostics的战略武器库和进展。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-09 DOI: 10.1080/09205063.2024.2396721

Ankit Kumar,Rahul Shukla

{"title":"Current strategic arsenal and advances in nose to brain nanotheranostics for therapeutic intervention of glioblastoma multiforme.","authors":"Ankit Kumar,Rahul Shukla","doi":"10.1080/09205063.2024.2396721","DOIUrl":"https://doi.org/10.1080/09205063.2024.2396721","url":null,"abstract":"The fight against Glioblastoma multiforme (GBM) is ongoing and the long-term outlook for GBM remains challenging due to low prognosis but every breakthrough brings us closer to improving patient outcomes. Significant hurdles in GBM are heterogeneity, fortified tumor location, and blood-brain barrier (BBB), hindering adequate drug concentrations within functioning brain regions, thus leading to low survival rates. The nasal passageway has become an appealing location to commence the course of cancer therapy. Utilization of the nose-to-brain (N2B) route for drug delivery takes a sidestep from the BBB to allow therapeutics to directly access the central nervous system (CNS) and enhance drug localization in the vicinity of the tumor. This comprehensive review provides insights into pertinent anatomy and cellular organization of the nasal cavity, present-day diagnostic tools, intracranial invasive therapies, and advancements in intranasal (IN) therapies in GBM models for better clinical outcomes. Also, this review highlights groundbreaking carriers and delivery techniques that could revolutionize GBM management such as biomimetics, image guiding-drug delivery, and photodynamic and photothermal therapies for GBM management.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0