Journal of Biomaterials Science, Polymer Edition最新文献_第2页

PLA/Ti6Al4V composite scaffolds for bone tissue engineering: mechanical and thermal properties via FDM and bioprinting. 用于骨组织工程的PLA/Ti6Al4V复合支架：FDM和生物打印的力学和热性能

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-09-29 DOI: 10.1080/09205063.2025.2564673

Hatice Evlen, Dilmurod Juraev, Umida Ziyamukhamedova, Muminjon Khujaev, Fazliddin Jalilov

{"title":"PLA/Ti6Al4V composite scaffolds for bone tissue engineering: mechanical and thermal properties via FDM and bioprinting.","authors":"Hatice Evlen, Dilmurod Juraev, Umida Ziyamukhamedova, Muminjon Khujaev, Fazliddin Jalilov","doi":"10.1080/09205063.2025.2564673","DOIUrl":"https://doi.org/10.1080/09205063.2025.2564673","url":null,"abstract":"An ideal bone substitute must exhibit high biocompatibility and mechanical reliability to facilitate integration with native bone. Polylactic acid (PLA), owing to its favorable biodegradability, thermoplastic nature, and bone-mimicking mechanical properties, has emerged as a promising scaffold material. In this study, PLA/Ti6Al4V (Ti64) composite scaffolds were fabricated using two additive manufacturing techniques: Fused Deposition Modeling (FDM) and extrusion-based 3D bioprinting. The composites were prepared in filament and bioink forms, respectively. To evaluate mineralization potential, scaffolds were immersed in simulated body fluid (SBF) for four weeks, and mass variation was recorded. Scanning electron microscopy (SEM) was used to examine surface morphology and pore architecture, while energy-dispersive X-ray spectroscopy (EDS) and elemental mapping verified the uniform dispersion of Ti64 particles within the PLA matrix. X-ray diffraction (XRD) further confirmed phase formation and the crystalline structure. Thermal analyses (TGA and DSC) indicated that increasing Ti64 content led to reduced thermal stability and crystallinity. Although the stiffness of neat PLA remained high, Ti64 reinforcement improved the compressive strength, aligning with the requirements for load-bearing applications, such as trabecular or craniofacial implants. Pore size measurements before and after SBF treatment revealed microstructural changes indicative of bioactivity. A comparison of scaffolds produced by FDM and bioprinting highlighted differences in pore geometry and biological performance. Collectively, the findings demonstrate that PLA/Ti64 composite scaffolds fabricated via both techniques exhibit favorable structural and mechanical characteristics, suggesting their strong potential for future use in bone tissue engineering.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-25"},"PeriodicalIF":3.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanocarriers in skincare: a review of current trends and future perspectives. 纳米载体在护肤中的应用：当前趋势和未来展望的综述。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-09-27 DOI: 10.1080/09205063.2025.2564676

Shreya Jayantibhai Gami, Tirtha Himanshubhai Mehta, Aryan Nanalal Sorathia, Bindu Kumari Nagendra Yadav, Shreeraj Shah

{"title":"Nanocarriers in skincare: a review of current trends and future perspectives.","authors":"Shreya Jayantibhai Gami, Tirtha Himanshubhai Mehta, Aryan Nanalal Sorathia, Bindu Kumari Nagendra Yadav, Shreeraj Shah","doi":"10.1080/09205063.2025.2564676","DOIUrl":"https://doi.org/10.1080/09205063.2025.2564676","url":null,"abstract":"Nanotechnology has transformed the administration of active compounds in cosmetics and dermatological products. It facilitates enhanced penetration, customised distribution, and improved treatment outcomes. Nanocarriers such as liposomes, nanoemulsions, dendrimers, and polymeric nanoparticles have emerged as effective methods for the controlled and sustained delivery of cosmetic and therapeutic agents. This paper provides a comprehensive overview of the current developments in the design, fabrication, and use of nanocarriers in skincare. This publication reviews the physicochemical properties, transdermal absorption, safety profile, and efficacy in addressing prevalent skin issues such as ageing, hyperpigmentation, acne, and skin inflammation. Additional regulatory challenges, market dynamics, and the complications associated with mass production and its translation into clinical use. With ongoing scientific advancements, skincare solutions using nanocarriers are expected to become fundamental in novel cosmetic and dermatological therapies.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-27"},"PeriodicalIF":3.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The promoting effect of Tween 60 on the formation of Kolliphor RH40 bicontinuous microemulsions. Tween 60对Kolliphor RH40双连续微乳形成的促进作用。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-09-26 DOI: 10.1080/09205063.2025.2561314

Ting Hou, Sida Zhang, Jiaqi Fu, Zan Li, Zhong Wang, Jinlian Li, Yanli Zhao, Yingxue Guo, Dongmei Wu

{"title":"The promoting effect of Tween 60 on the formation of Kolliphor RH40 bicontinuous microemulsions.","authors":"Ting Hou, Sida Zhang, Jiaqi Fu, Zan Li, Zhong Wang, Jinlian Li, Yanli Zhao, Yingxue Guo, Dongmei Wu","doi":"10.1080/09205063.2025.2561314","DOIUrl":"https://doi.org/10.1080/09205063.2025.2561314","url":null,"abstract":"The formation of bicontinuous microemulsions requires large amounts of surfactants, limiting their applications. This study aims to explore the regulatory effect of composite surfactants on the transition of microemulsion systems from the W/O phase to the bicontinuous phase. Through ternary phase diagram analysis, viscosity measurement, conductivity test, dynamic light scattering analysis, rheological analysis and surface tension test, it investigates the regulatory effects of composite surfactant systems formed by PEG-100 stearate, Tween 60, and Span 60 each with Kolliphor RH40 on the transition. Ternary phase diagrams show that Tween 60, compared with Kolliphor RH40 alone, raises the maximum dilution line from L82 to L64, reducing surfactant use and broadening the range; PEG-100 stearate shows no improvement, while Span 60 lowers the line. Viscosity, conductivity and dynamic light scattering results indicate that Tween 60 reduces the water content required for transition from 40% to 35%, aiding the formation of the bicontinuous region. Rheological tests show that Tween 60 reduces the loss modulus and improves interfacial film integrity; surface tension tests confirm the further lowering of surface tension to promote the transition. Antibacterial tests show that the MIC and MBC of the Kolliphor RH40/Tween 60 system are 5.3 μg/mL and 7.8 μg/mL, lower than those of Kolliphor RH40 alone. It exhibits excellent stability under infinite dilution and in extreme environments. In conclusion, Kolliphor RH40/Tween 60 effectively regulates bicontinuous microemulsion formation, improves performance, and provides practical application ideas.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-19"},"PeriodicalIF":3.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan-coated boronic acid modified magnetic alginate microbeads: dual encapsulation and release of 5-fluorouracil and resveratrol. 壳聚糖包被硼酸修饰的磁性海藻酸微球：5-氟尿嘧啶和白藜芦醇的双重包封和释放。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-09-26 DOI: 10.1080/09205063.2025.2564679

Rukiye Yavaşer Boncooğlu, Demet Yalçin Bingül

{"title":"Chitosan-coated boronic acid modified magnetic alginate microbeads: dual encapsulation and release of 5-fluorouracil and resveratrol.","authors":"Rukiye Yavaşer Boncooğlu, Demet Yalçin Bingül","doi":"10.1080/09205063.2025.2564679","DOIUrl":"https://doi.org/10.1080/09205063.2025.2564679","url":null,"abstract":"In this study, it was aimed to develop magnetic microbeads for dual delivery of 5-Fluorouracil (5-FU) and Resveratrol (RES). Fe3O4 nanoparticles were coated with alginate, modified with 3-aminophenylboronic acid (APBA) by carbodiimide chemistry, gelled with CaCl2, and coated with chitosan after drug loading by swelling method. FTIR, TEM, SEM, ESR, and XRD were used for characterization. Microbeads were further investigated for entrapment efficiency (EE), swelling analysis, in vitro release, and cytotoxicity. Entrapment efficiencies were 62.2 ± 0.78 and 27.1 ± 0.98% w/w for 5-FU and RES, respectively. Drug release was studied at pH 1.5, 5.5, 6.8, and 7.4. Microbeads exhibited the highest release at pH 6.8 (65.3 ± 2.50% w/w for 5-FU and 45.4 ± 1.80% w/w for RES). Release kinetics conformed to Higuchi model at pH 6.8 and Korsmeyer-Peppas at pHs 5.5 and 7.4. Microbeads containing 300 µg/mL drug reduced cell viability of HT-29 colon cancer cell line below 50% in cytotoxicity experiments.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in application of layered double hydroxide/polymer nanocomposites for bone tissue engineering. 层状双氢氧化物/聚合物纳米复合材料在骨组织工程中的应用进展。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-09-25 DOI: 10.1080/09205063.2025.2564672

Mahnaz Shavandi, Seyedeh Sara Shafiei, Mehran Solati-Hashjin

{"title":"Advances in application of layered double hydroxide/polymer nanocomposites for bone tissue engineering.","authors":"Mahnaz Shavandi, Seyedeh Sara Shafiei, Mehran Solati-Hashjin","doi":"10.1080/09205063.2025.2564672","DOIUrl":"https://doi.org/10.1080/09205063.2025.2564672","url":null,"abstract":"Layered double hydroxides (LDHs), or hydrotalcite-like compounds, are versatile, biocompatible nano-clays with promising bone tissue engineering (BTE) applications. These two-dimensional nanomaterials are incorporated into biomaterials to enhance biocompatibility, bioactivity, and natural biodegradability. Furthermore, compositional flexibility and efficient surface modification of LDHs enable the use of functionalized LDH across various biomedical applications. Additionally, LDHs facilitate cell proliferation, expansion, and migration and promote stem cell differentiation into osteoblasts. Their layered structure, consisting of charged cationic layers and exchangeable anionic interlayers, makes them promising candidates for BTE. This review explores the characteristics and potential uses of LDH nanocomposite scaffolds, including bioactivity, antibacterial properties, drug and gene delivery, and tissue engineering. It focuses on their molecular mechanism and recent advances in using LDHs for BTE applications. Eventually, a concluding remark and a future perspective in research related to LDHs are provided.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-28"},"PeriodicalIF":3.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of 3D printed biodegradable polymer-based drug delivery implants for post cataract surgery treatment. 用于白内障术后治疗的3D打印可生物降解聚合物给药植入物的开发。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-09-21 DOI: 10.1080/09205063.2025.2561003

Nayana E Subhash, Soumya Nair, Srilatha Parampalli Srinivas, Sulatha V Bhandary, Bharath Raja Guru

{"title":"Development of 3D printed biodegradable polymer-based drug delivery implants for post cataract surgery treatment.","authors":"Nayana E Subhash, Soumya Nair, Srilatha Parampalli Srinivas, Sulatha V Bhandary, Bharath Raja Guru","doi":"10.1080/09205063.2025.2561003","DOIUrl":"https://doi.org/10.1080/09205063.2025.2561003","url":null,"abstract":"Cataracts affect millions of people worldwide; surgery and intensive post-operative care are the current standard of treatment. However, ocular barriers to drug delivery often impede recovery after surgery. This study proposes a potential solution to enhance post-cataract care by developing a biodegradable, controlled-release implant using 3D printing technology and follows the guidelines given by the All-India Ophthalmological Society (AIOS). The implant was designed to be placed into the capsular bag of the eye during the surgery and employs Poly(lactic-co-glycolic acid) (PLGA) as a drug carrier, delivering a combination of drugs such as Dexamethasone (DEX), Moxifloxacin (MOX), and Nepafenac (NEPA) directly into the eye. Two sets of drugs loaded implants were prepared, namely DEX-MOX-PLGA and NEPA-PLGA to mimic the conventional administration of corresponding eye drops used in post-operative management. A two-step process involving hot-melt extrusion and 3D printing, was utilised to prepare these implants. The prepared implants were characterised and the in vitro results aligned with the clinically prescribed regimens. The prepared implants were able to overcome the challenges like consistency of size and the in vitro release profile which were encountered in the previously published hot-melt extrusion only study. This approach demonstrates the feasibility of combining cataract surgery with post-operative drug delivery in a single procedure. The implants provided sustained drug release profiles consistent with clinical dosing regimens and were well substantiated in in vivo rabbit model, supporting their potential to improve patient compliance and recovery in future therapeutic applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.6,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of polyvinyl alcohol-polyethylene glycol-copper oxide nanocomposite hydrogel as a novel wound dressing. 新型伤口敷料聚乙烯醇-聚乙二醇-氧化铜纳米复合水凝胶的制备。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-09-20 DOI: 10.1080/09205063.2025.2561005

Rana Arefi, S A Hassanzadeh-Tabrizi, Narjes Koupaei, Mohammad Salmani Mobarakeh, Hashim Hamood Jabbar Al-Gburi

{"title":"Fabrication of polyvinyl alcohol-polyethylene glycol-copper oxide nanocomposite hydrogel as a novel wound dressing.","authors":"Rana Arefi, S A Hassanzadeh-Tabrizi, Narjes Koupaei, Mohammad Salmani Mobarakeh, Hashim Hamood Jabbar Al-Gburi","doi":"10.1080/09205063.2025.2561005","DOIUrl":"https://doi.org/10.1080/09205063.2025.2561005","url":null,"abstract":"This study aimed to design a new hydrogel wound dressing using polyvinyl alcohol (PVA), polyethylene glycol (PEG), and copper oxide (CuO) via the solvent casting method. Firstly, copper oxide nanoparticles were synthesized using a sol-gel method. Then, the produced CuO was added to the polymer mixture solution. Glutaraldehyde solution was employed to crosslink the samples. The samples' water absorption, gel fraction, water vapor transmission, and mechanical properties were evaluated. The results indicate that increasing the weight percentage of copper oxide improved water absorption and mechanical properties of the wound dressing hydrogels. Additionally, the water vapor transmission rate through the samples decreased with the increase in the weight of copper oxide. The results of the antibacterial properties examination suggested that the samples with 1% copper oxide had the highest antibacterial properties against Staphylococcus aureus and Escherichia coli. All the samples had a cell viability higher than 70%. As a result, the PVA/PEG/CuO hydrogel can be a good candidate for wound dressing.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a fibrous poly (xylitol sebacate) sheet for endothelial basement membrane tissue engineering. 用于内皮基膜组织工程的聚木糖醇脂酸纤维片的研制。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-09-19 DOI: 10.1080/09205063.2025.2561316

Hanieh Lavarian, Faraz Sigaroodi, Camellia Ganjoury, Setayesh Salamati, Bahman Vahidi, Najmeh Najmoddin, Hadi Baharifar, Mohammad-Mehdi Khani

{"title":"Development of a fibrous poly (xylitol sebacate) sheet for endothelial basement membrane tissue engineering.","authors":"Hanieh Lavarian, Faraz Sigaroodi, Camellia Ganjoury, Setayesh Salamati, Bahman Vahidi, Najmeh Najmoddin, Hadi Baharifar, Mohammad-Mehdi Khani","doi":"10.1080/09205063.2025.2561316","DOIUrl":"https://doi.org/10.1080/09205063.2025.2561316","url":null,"abstract":"An essential part of designing cardiovascular grafts is the fabrication of an artificial endothelial basement membrane (EBM) with the ability to support endothelial differentiation, especially under physiological dynamic forces. In this study, we introduce a novel artificial EBM constructed from a poly (xylitol sebacate) (PXS) polymer. First, the PXS prepolymer (pPXS) was blended with polyvinyl alcohol (PVA) at different ratios to achieve optimized production with a minimum amount of PVA to fabricate well-organized electrospun fiber networks of pPXS/PVA. Subsequently, pPXS/PVA was cross-linked at 120 °C under vacuum for two days to form a cPXS/PVA meshwork. Then, PVA and remaining pPXS were removed from the cPXS/PVA meshworks by serial rinsing in deionized water and ethanol to fabricate a defect-free fibrous sheet of cPXS. The fibrous cPXS sheets were characterized in terms of their structural, mechanical, and biological performance. The results confirmed that the cPXS sheets exhibited appropriate mechanical strength, acceptable wettability, ideal porosity, degradation behavior, and superior biocompatibility. Moreover, cPXS, as an artificial EBM, is capable of supporting endothelial differentiation of mesenchymal stem cells under dynamic culture conditions in a parallel plate bioreactor. Therefore, it can be inferred that fibrous cPXS sheet can be an ideal candidate for EBM tissue engineering and development of functional cardiovascular grafts.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-19"},"PeriodicalIF":3.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan-pectin complexes: a new frontier in biopolymer-based drug delivery systems. 壳聚糖-果胶复合物：生物聚合物为基础的给药系统的新前沿。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-09-19 DOI: 10.1080/09205063.2025.2561007

Sandhya Jadhav, Ritika Khivansara, Atul P Sherje

{"title":"Chitosan-pectin complexes: a new frontier in biopolymer-based drug delivery systems.","authors":"Sandhya Jadhav, Ritika Khivansara, Atul P Sherje","doi":"10.1080/09205063.2025.2561007","DOIUrl":"https://doi.org/10.1080/09205063.2025.2561007","url":null,"abstract":"Natural polysaccharides like pectin and chitosan have attracted a lot of attention in biopolymer research because of their diverse range of possible uses and special physicochemical characteristics. Each polymer has advantageous qualities on its own. For example, pectin is known for its gelling ability and biocompatibility, while chitosan is recognized for its antibacterial, mucoadhesive, and biodegradable qualities. Through electrostatic interactions between the negatively charged carboxyl groups of pectin and the positively charged amino groups of chitosan, these biopolymers join to form a chitosan-pectin complex. When compared to the separate polymers, this combination produces a flexible and structurally stable material with improved mechanical strength, stability, and biocompatibility. The chitosan-pectin complex is a great option for a variety of drug delivery applications because of its advantageous physicochemical characteristics, which include pH responsiveness and regulated drug release. These include oral tablets, hydrogels, films, and nanoparticles, where the complex can enhance therapeutic efficacy and allow for the targeted administration of drugs to specific sites in the body. Notably, this biopolymer system exhibits significant promise for improving prolonged drug release characteristics, lowering adverse effects, and increasing bioavailability. With an emphasis on their uses in cutting-edge drug delivery systems, this review attempts to provide a thorough understanding of the synthesis techniques and structural features of chitosan-pectin complexes. It also looks at new developments and potential application of chitosan-pectin-based polymers in the biomedical and pharmaceutical industries.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradable chitosan lactate/polyvinyl alcohol composite sponge for rapid hemostasis and antibacterial protection. 生物可降解乳酸壳聚糖/聚乙烯醇复合海绵，用于快速止血和抗菌保护。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-09-18 DOI: 10.1080/09205063.2025.2561322

Raziyeh Ghelich, Laleh Foroutani, Pouyan Sanjarari Pirayvatlou, Peyman Sanjaripirayvatlou, Mohammad Sadegh Fazeli, Behnam Behboudi, Seyed Mohsen Ahmadi Tafti

{"title":"Biodegradable chitosan lactate/polyvinyl alcohol composite sponge for rapid hemostasis and antibacterial protection.","authors":"Raziyeh Ghelich, Laleh Foroutani, Pouyan Sanjarari Pirayvatlou, Peyman Sanjaripirayvatlou, Mohammad Sadegh Fazeli, Behnam Behboudi, Seyed Mohsen Ahmadi Tafti","doi":"10.1080/09205063.2025.2561322","DOIUrl":"https://doi.org/10.1080/09205063.2025.2561322","url":null,"abstract":"Severe bleeding is one of the most life-threatening emergencies, and its rapid control is critical for saving millions of lives each year. The aim of this study was to develop an antibacterial wound dressing based on chitosan lactate (CL)/polyvinyl alcohol (PVA) composite sponges, prepared via a freeze-drying process without the use of toxic crosslinking agents, and to evaluate their hemostatic effectiveness in controlling femoral artery bleeding in an animal model. The CL/PVA sponges exhibited a crystalline, interconnected porous structure with a mean pore size of 120 µm. A swelling ratio of approximately 500% was observed, and the sponges were almost completely degraded after 7 d of incubation in simulated body fluid. The composite sponges showed antibacterial activity of 99% against Escherichia coli and 33% against Staphylococcus aureus. In a femoral artery perforation test, CL/PVA sponges effectively stopped bleeding within 59.62 ± 11.89 s, whereas the control group required 117.5 ± 3.25 s - a statistically significant difference (p < 0.001). Characterizing the properties of this material in relation to blood coagulation physiology suggests its potential for controlling life-threatening hemorrhages in emergency situation.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-15"},"PeriodicalIF":3.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0