Journal of Biomaterials Science, Polymer Edition最新文献_第2页

Exploration of mechanical properties and osseointegration capacity of porous PEEK composites containing strontium and alendronate under 3D printing: an emerging bone implant. 含锶和阿仑膦酸的多孔 PEEK 复合材料在 3D 打印下的机械性能和骨结合能力探索：一种新兴的骨植入物。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-15 DOI: 10.1080/09205063.2024.2438498

Binwei Qin, Baifang Zeng, Danwei Shen, Jiayan Deng, Haigang Hu, Xiangyu Wang, Hong Li, Taicong Yang, Lian Xu, Chao Wu

{"title":"Exploration of mechanical properties and osseointegration capacity of porous PEEK composites containing strontium and alendronate under 3D printing: an emerging bone implant.","authors":"Binwei Qin, Baifang Zeng, Danwei Shen, Jiayan Deng, Haigang Hu, Xiangyu Wang, Hong Li, Taicong Yang, Lian Xu, Chao Wu","doi":"10.1080/09205063.2024.2438498","DOIUrl":"https://doi.org/10.1080/09205063.2024.2438498","url":null,"abstract":"The aim of this study was to evaluate the biomechanical and osseointegrative properties of 3D printed porous PEEK materials loaded with strontium (Sr) and alendronate (ALN), which prepared porous cylindrical material by a fused deposition molding process, coated with Sr and ALN by hydrothermal reaction and dopamine assistance. According to the different coating materials, it could be divided into the PEEK group, PEEK-ALN group, PEEK-Sr group and PEEK-ALN-Sr group. After completing the mechanical analyses, the materials were implanted into the femoral condyles of New Zealand rabbits and the osteogenic capacity of the bracket materials was assessed by Micro-CT scanning, histology and fluorescence staining. The results showed that ALN and Sr were successfully loaded onto the surface of the material, and the elastic modulus and porosity of the material were not changed significantly after loading. The Micro-CT revealed that the PEEK-ALN-Sr group exhibited differences in bone volume/total Volume (BV/TV), trabecular spacing (TB.Sp),trabecular thickness (TB.Th)and trabeculae number (TB.N) in comparison to the PEEK group and PEEK-ALN group. And more new bone tissues could be observed in the PEEK-ALN-Sr group under 3D reconstruction of the bone proliferation model, toluidine blue and fluorescence staining. Thus, we can conclude that the 3D printed porous PEEK material has stable pore size and porosity, which has an ideal structure for bone growth. The PEEK- ALN-Sr composite material can be used as an emerging bone implant due to its excellent elastic modulus and osseointegration ability and provides a clinically viable treatment for patients with bone defects.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-16"},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alkaline etching assisted polydopamine coating for enhanced cell-material interactions on 3D printed polylactic acid scaffolds. 碱性蚀刻辅助聚多巴胺涂层可增强三维打印聚乳酸支架上细胞与材料的相互作用。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-15 DOI: 10.1080/09205063.2024.2436691

Athira Murali, Ramesh Parameswaran

{"title":"Alkaline etching assisted polydopamine coating for enhanced cell-material interactions on 3D printed polylactic acid scaffolds.","authors":"Athira Murali, Ramesh Parameswaran","doi":"10.1080/09205063.2024.2436691","DOIUrl":"https://doi.org/10.1080/09205063.2024.2436691","url":null,"abstract":"The implant surface chemistry and topography are primary factors regulating the success and survival of bone scaffold. Surface modification is a promising alternative to enhance the biocompatibility and tissue response to augment the osteogenic functionalities of polyesters like PLA. The study employed the synergistic effect of alkaline hydrolysis and polydopamine (PDA) functionalization to enhance the cell-material interactions on 3D printed polylactic acid (PLA) scaffold. Comprehensive characterization of the modified PLA highlights the improvements in the physical, chemical and cell-material interactions upon two-step surface modification. The X-ray photoelectron spectroscopy (XPS) analysis substantiated enhanced PDA deposition with a ∼8.2% increase in surface N composition after surface etching due to homogeneous PDA deposition compared to the non-etched counterpart. The changes in surface chemistry and morphology upon dual surface modification complemented the human osteoblast (HOS) attachment and proliferation, with distinct cell morphology and spreading on PDA coated etched PLA (Et-PLAPDA) scaffolds. Moreover, substantial improvement in osteogenic differentiation of UMR-106 cells on etched PLA (Et-PLA) and Et-PLAPDA highlights the suitability of alkali etching-mediated PDA deposition to improve mineralization on PLA. Overall, the present work opens insights to modify scaffold surface composition, topography, hydrophilicity and roughness to regulate local cell adhesion to improve the osteogenic potential of PLA.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-26"},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pluronic F-127 coated zinc oxide nanoparticles from Gynura pseudochina: a comprehensive assessment of antibacterial, and anticancer activities.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-14 DOI: 10.1080/09205063.2024.2434307

Murugan Alwarkurichi Munusamy, Muruganantham Bharathi, Abdullah A Alarfaj, Samer Hasan Hussein-Al-Ali, Subbarayan Sarathbabu

{"title":"Pluronic F-127 coated zinc oxide nanoparticles from Gynura pseudochina: a comprehensive assessment of antibacterial, and anticancer activities.","authors":"Murugan Alwarkurichi Munusamy, Muruganantham Bharathi, Abdullah A Alarfaj, Samer Hasan Hussein-Al-Ali, Subbarayan Sarathbabu","doi":"10.1080/09205063.2024.2434307","DOIUrl":"https://doi.org/10.1080/09205063.2024.2434307","url":null,"abstract":"The study synthesized Pluronic F-127 coated zinc oxide nanoparticles (PF-127ZnO NPs) using Gynura pseudochina leaf extract and evaluated their antibacterial, antioxidant, and anticancer properties using various characterization methods such as UV-Vis, Fourier Transform Infra-Red, Photoluminescence spectroscopy, FESEM, EDAX, TEM, SAED, XRD, and DLS. The disc diffusion technique was used to evaluate the antibacterial properties of synthesized Pluronic F-127 coated zinc oxide nanoparticles against various pathogens and significant anticancer activity was noticed. The study examined the cytotoxicity of PF127ZnO nanoparticles to Hep3B cells in vitro. The cytotoxicity was IC50 at 10 µM concentration. The study examined the biocompatibility of PF-127ZnO NPs, revealing membrane blebbing, chromatin condensation, and stimulation of the proapoptotic protein caspase cascade family. The study reveals that PF-127ZnO NPs, synthesized from G. pseudochina leaf extract, exhibit antibacterial and antihepatic properties, offering potential biomedical applications due to their high stability and biocompatibility.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-09 DOI: 10.1080/09205063.2024.2436824

引用次数: 0

Natural Fiber-Based Polymer Composites for Biomedical Applications.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-09 DOI: 10.1080/09205063.2024.2435722

Emel Kuram

引用次数: 0

Recent developments in photothermal therapy: a bibliometric and visual analysis.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-08 DOI: 10.1080/09205063.2024.2434308

Runying Guo, Rongrong Zhang, Yuqi Xin, Zhonghao Wang, Zichen Xu, Jiaxuan Qiu

{"title":"Recent developments in photothermal therapy: a bibliometric and visual analysis.","authors":"Runying Guo, Rongrong Zhang, Yuqi Xin, Zhonghao Wang, Zichen Xu, Jiaxuan Qiu","doi":"10.1080/09205063.2024.2434308","DOIUrl":"https://doi.org/10.1080/09205063.2024.2434308","url":null,"abstract":"Photothermal therapy (PTT) has recently garnered significant attention as a prominent noninvasive treatment modality for a broad spectrum of diseases. Despite the increasing volume of scholarly output over the last 20 years, a holistic synthesis that delineates worldwide research trajectories remains elusive. We undertook a bibliometric analysis of the literature from 2004 to 2023, aiming to delineate the prevailing focal points and illuminate prospective research avenues. Research articles on PTT were retrieved from the Web of Science Core Collection. Using tools such as CiteSpace, VOSviewer, and Bibliometrix, we comprehensively analyzed and visualized 11,184 published academic PTT papers. China has the highest number of publications. Journals related to PTT are primarily comprised of interdisciplinary and comprehensive journals. Research associated with PTT has focused primarily on its antitumor properties. Current focal areas in this domain include the synergistic combination of PTT with photodynamic therapy, immunological mechanisms of PTT to enhance its therapeutic efficacy, integrated use of PTT with nanoenzyme catalysis, and the role of PTT in antimicrobial applications. This bibliometric analysis provides an initial comprehensive examination of the medical applications of PTT, offering insights into the global research landscape, key areas of interest, and emerging trends, thereby serving as a valuable reference for future studies in this field.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-21"},"PeriodicalIF":3.6,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of inulin nanocarrier for effective oral delivery of insulin: synthesize, optimization, characterization, and biophysical study.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-04 DOI: 10.1080/09205063.2024.2436297

Achmad Ramadhanna'il Rasjava, Desy Kurniawati, Wa Ode Sri Rizki, Neng Fisheri Kurniati, Rukman Hertadi

{"title":"Development of inulin nanocarrier for effective oral delivery of insulin: synthesize, optimization, characterization, and biophysical study.","authors":"Achmad Ramadhanna'il Rasjava, Desy Kurniawati, Wa Ode Sri Rizki, Neng Fisheri Kurniati, Rukman Hertadi","doi":"10.1080/09205063.2024.2436297","DOIUrl":"https://doi.org/10.1080/09205063.2024.2436297","url":null,"abstract":"The susceptibility of insulin against gastric acid degradation presents a major challenge for oral insulin delivery. The potential of biopolymer-based nanocarriers was investigated in order to address this issue. Inulin, a biopolymer produced by the halophilic bacterium Salinivibrio sp. GM01, has been evaluated for its effectiveness as an insulin nanocarrier. Using central composite design (CCD) method, the optimum condition of inulin-encapsulated insulin (I-In) was achieved at 53 mg of inulin stirred at 17,800 rpm for 10 min, resulting in spherical I-In nanoparticles (I-In NPs) with an average diameter of 416 ± 32 nm and encapsulation efficiency of 87.04 ± 3.01%. The insulin release profile of I-In NPs in simulated gastric fluid follows a burst pattern. Biophysical analysis revealed that insulin in I-In NPs had higher conformational stability than the free state (FS) insulin, as evidenced by an increase in denaturation half-life up to 60 min and the transition enthalpy by 0.29 and 1.53 kcal/mol for secondary and tertiary structures, respectively. Furthermore, preliminary in vivo studies showed that I-In NPs showed significant effect compared to FS insulin for up to 15% in blood glucose level reduction. This study demonstrates the potential of I-In NPs as a promising candidate for antidiabetic therapy and an effective oral delivery system.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the in vitro and in vivo effects of carvacrol zinc oxide quantum dots in breast cancer.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-03 DOI: 10.1080/09205063.2024.2429325

Manoj Kumar Srinivasan, Nalini Namasivayam

{"title":"Evaluating the in vitro and in vivo effects of carvacrol zinc oxide quantum dots in breast cancer.","authors":"Manoj Kumar Srinivasan, Nalini Namasivayam","doi":"10.1080/09205063.2024.2429325","DOIUrl":"10.1080/09205063.2024.2429325","url":null,"abstract":"The study investigates the molecular interactions and biological effects of carvacrol zinc oxide quantum dots (CVC-ZnO QDs) on breast cancer in vitro MCF-7 cell lines and in vivo mammary cancer models. Molecular docking using AutoDock Vina revealed binding energies of CVC with key proteins in the PI3K/AKT/mTOR pathway, including PI3K, AKT, PTEN, and mTOR. The results showed significant interaction with specific amino acids, indicating a strong binding affinity. In vitro studies demonstrated a dose-dependent cytotoxic effect of CVC-ZnO QDs on MCF-7 cells, with an IC50 of 20.02 µg/mL, while enhancing intracellular reactive oxygen species (ROS) and decreasing mitochondrial membrane potential (MMP), indicative of apoptosis induction. Antioxidant activity, lipid peroxidation, and nuclear morphological changes were assessed, revealing decreased antioxidant status and increased lipid peroxidation in treated cells. In vivo, CVC-ZnO QDs modulated the PI3K/AKT/mTOR signaling in DMBA-induced mammary cancer in rats, decreasing p-PI3K, p-AKT, and p-mTOR expression while upregulating PTEN. Immunohistochemistry, qRT-PCR, and Western blot analyses confirmed these molecular alterations. The study concludes that CVC-ZnO QDs exert cytotoxic and pro-apoptotic effects on breast cancer cells by modulating the PI3K/Akt/mTOR pathway and promoting oxidative stress, presenting a potential therapeutic strategy for breast cancer management.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ionic conducting hydrogels as biomedical materials: classification, design strategies, and skin tissue engineering applications.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-02 DOI: 10.1080/09205063.2024.2434300

Wanping Zhang, Zhe Li, Qianjie Zhang, Shilian Zheng, Zijia Zhang, Simin Chen, Zixin Wang, Dongmei Zhang

{"title":"Ionic conducting hydrogels as biomedical materials: classification, design strategies, and skin tissue engineering applications.","authors":"Wanping Zhang, Zhe Li, Qianjie Zhang, Shilian Zheng, Zijia Zhang, Simin Chen, Zixin Wang, Dongmei Zhang","doi":"10.1080/09205063.2024.2434300","DOIUrl":"https://doi.org/10.1080/09205063.2024.2434300","url":null,"abstract":"Ionically conductive hydrogels (ICHs) are considered promising flexible electronic devices and various wearable sensors due to the integration of the conductive performance and soft nature of human tissue-like materials with mechanical and sensory traits. Recently, substantial progress has been made in the research of ICHs, including high conductivity, solution processability, strong adhesion, high stretchability, high self-healing ability, and good biocompatibility. These advanced researches also promote their excellent application prospects in medical monitoring, sports health, smart wear, and other fields. This article reviewed ICHs' current classification and design strategies in biomedical applications and the structure-activity relationship of the interface between biological systems and electronics. Furthermore, the typical cases of frontiers of skin interface applications of ICHs were elaborated in transdermal drug delivery, wound healing, disease diagnosis and treatment, and human-computer interaction. This article aims to inspire related research on ionically conductive hydrogels in the biomedical field and promote the innovation and application of flexible wearable electronic device technology.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro chondrogenic potential of marine biocomposite hydrogel construct for cartilage tissue engineering. 用于软骨组织工程的海洋生物复合水凝胶构建体的体外软骨生成潜能。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-10-21 DOI: 10.1080/09205063.2024.2391223

Sumayya A S, Muraleedhara Kurup G

{"title":"In vitro chondrogenic potential of marine biocomposite hydrogel construct for cartilage tissue engineering.","authors":"Sumayya A S, Muraleedhara Kurup G","doi":"10.1080/09205063.2024.2391223","DOIUrl":"10.1080/09205063.2024.2391223","url":null,"abstract":"Cartilage tissue engineering (CTE) is a field of regenerative medicine focused on constructing ideal substitutes for injured cartilage by effectively combining cells, scaffolds, and stimulatory factors. In vitro CTE employing chondrocytes and biopolymer-based hydrogels has the potential to repair damaged cartilage. In this research, primary chondrocytes were extracted from the rib cartilage of rats and seeded on a hydrogel construct named HACF, which is made from hydroxyapatite, alginate, chitosan, and fucoidan. We then evaluated in vitro chondrogenesis on HACF cartilage construct. The results revealed that the primary chondrocytes were successfully isolated from rat rib cartilage by collagenase D digestion and HACF cartilage construct was effectively synthesized. Chondrocyte viability and its differentiation inside the scaffold HACF were determined by MTT assay, NRU assay, live/dead assay, DAPI nuclear staining, flow cytometry analysis (FCA), mRNA expression studies, and quantification of extracellular matrix components in the HACF scaffold. The findings indicated excellent chondrocyte viability within the HACF scaffold, with no noticeable changes in morphology. Apoptosis was not detected in the chondrocytes cultured on these hydrogels, as confirmed by DAPI staining, live/dead assay, and FCA. This demonstrates that the cells were capable of proliferating, dividing, multiplying, and maintaining their integrity on HACF scaffold. The results also showed more collagen deposition and glycosaminoglycan synthesis showing the good health of chondrocytes on the HACF construct. It indicates that HACF is an ideal scaffold supporting stable cartilage matrix production, highlighting its suitability for cartilage tissue engineering.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2845-2866"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0