Journal of Biomaterials Science, Polymer Edition最新文献_第2页

Synthesis of CQD-doped and bio-based chitosan-starch-locust bean gum composite polymeric films for cell growth and pH-responsive drug release. cqd掺杂生物基壳聚糖-淀粉-刺槐豆胶复合聚合物膜的合成及其在细胞生长和ph响应药物释放中的应用。

IF 3.5 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-10-13 DOI: 10.1080/09205063.2026.2743122

Halis Can Mörel, Ayşe Z Aroguz, Merve Kayis, Zelal Adiguzel

{"title":"Synthesis of CQD-doped and bio-based chitosan-starch-locust bean gum composite polymeric films for cell growth and pH-responsive drug release.","authors":"Halis Can Mörel, Ayşe Z Aroguz, Merve Kayis, Zelal Adiguzel","doi":"10.1080/09205063.2026.2743122","DOIUrl":"https://doi.org/10.1080/09205063.2026.2743122","url":null,"abstract":"Recently, Carbon Quantum Dots (CQDs) have been heralded as economically and ecologically friendlier alternatives to their traditional counterparts. In this study, we aimed to investigate how carbon-source pretreatment and N-doping affect poppyseed-derived CQDs and whether these differences influence the drug delivery and cell growth properties of CQD-incorporated bio-based polymeric films. CQDs were synthesized hydrothermally from unaltered, ground, and oil-extracted poppyseeds, both with and without N-doping, and subsequently incorporated into Chitosan-Starch-Locust Bean Gum (LBG) blends crosslinked with citric acid and prepared by solvent casting. N-doping resulted in a 1.81-fold increase in emission intensity together with an approximately 46 nm blueshift, while oil extraction also increased the emission intensity of the obtained CQDs. The films were evaluated for swelling, Diclofenac Diethylamine loading and pH-responsive release, and L929 mouse fibroblast growth over 72 h. The highest drug loading capacity was approximately 78% for the control 12:2:1 Chitosan/LBG/Starch formulation, while CQD-containing films generally demonstrated lower but formulation-dependent loading capacities. Drug release was strongly dependent on pH, occurring from fastest to slowest at pH 7.4 (≈10-100 min), pH 2.3 (≈160-280 min), and pH 5.5 (≈24-30 h). Release kinetics likewise varied according to pH and formulation, indicating that the governing release mechanism was not uniform across the films. CQD-containing films also demonstrated increased L929 cell growth compared with the corresponding CQD-free sample, reaching an average 2.3-fold increase after 72 h. Overall, the CQD-integrated polymer films have favorable drug loading/release and cell growth properties, showing great potential for biomedical and tissue engineering applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-29"},"PeriodicalIF":3.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired chondroitin sulfate/poly(levodopa) hydrogels as photothermal platforms for NIR controlled drug release and cartilage tissue engineering. 生物激发硫酸软骨素/聚左旋多巴水凝胶作为近红外药物释放和软骨组织工程的光热平台。

IF 3.5 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-10-13 DOI: 10.1080/09205063.2026.2746383

Kelly Obando Hurtado, Brianda M Salazar Salas, Arely M González-González, Dora E Rodríguez Félix, Lerma H Chan Chan, Jesús M Quiroz Castillo, Tomás J Madera Santana, Raul Rosales-Ibáñez, Teresa Del Castillo Castro

{"title":"Bioinspired chondroitin sulfate/poly(levodopa) hydrogels as photothermal platforms for NIR controlled drug release and cartilage tissue engineering.","authors":"Kelly Obando Hurtado, Brianda M Salazar Salas, Arely M González-González, Dora E Rodríguez Félix, Lerma H Chan Chan, Jesús M Quiroz Castillo, Tomás J Madera Santana, Raul Rosales-Ibáñez, Teresa Del Castillo Castro","doi":"10.1080/09205063.2026.2746383","DOIUrl":"https://doi.org/10.1080/09205063.2026.2746383","url":null,"abstract":"Stimuli-responsive hydrogels capable of combining tissue regeneration with on-demand drug delivery represent an attractive strategy for cartilage repair. In this work, bioinspired chondroitin sulfate/poly(levodopa) (CS/P(L-DOPA)) hydrogels were prepared through EDC/NHS-mediated self-crosslinking of CS followed by the in situ polymerization of L-DOPA to generate a secondary eumelanin photothermal network. The hydrogels were characterized by FTIR spectroscopy, swelling measurements, SEM, photothermal performance, NIR-triggered ibuprofen release, cytocompatibility, and chondrogenic differentiation assays. The incorporation of P(L-DOPA) preserved the interconnected porous morphology while reducing equilibrium swelling under physiological conditions through additional intermolecular interactions. CS/P(L-DOPA) hydrogels exhibited an efficient photothermal conversion upon NIR irradiation, reaching temperatures of 43-46 °C. NIR irradiation promotes the ibuprofen release from the hydrogels, demonstrating remote-controlled drug delivery. In vitro studies confirmed cell viabilities above 80% in L-929 fibroblasts and dental pulp stem cells, while cytoskeletal staining revealed enhanced cell organization. Safranin O and Alcian Blue staining showed an increase in glycosaminoglycan- and proteoglycan-rich extracellular matrix deposition, consistent with a chondrogenic response of the stem cells. These findings demonstrate the potential of CS/P(L-DOPA) hydrogels as a multifunctional platform for NIR-controlled drug delivery and cartilage tissue engineering.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-20"},"PeriodicalIF":3.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maltoheptaose-functionalized cellulose nanocrystals for curcumin delivery and light-responsive antibacterial activity. 麦芽糖葡聚糖功能化纤维素纳米晶体用于姜黄素传递和光响应抗菌活性。

IF 3.5 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-10-13 DOI: 10.1080/09205063.2026.2746386

Respina Arefizadeh, Abbas Dadkhah Tehrani, Mika Sillanpää

{"title":"Maltoheptaose-functionalized cellulose nanocrystals for curcumin delivery and light-responsive antibacterial activity.","authors":"Respina Arefizadeh, Abbas Dadkhah Tehrani, Mika Sillanpää","doi":"10.1080/09205063.2026.2746386","DOIUrl":"https://doi.org/10.1080/09205063.2026.2746386","url":null,"abstract":"The utilization of natural polysaccharides for the development of nanostructured systems aligns with the principles of green chemistry and environmental sustainability. This study reports the synthesis of novel polysaccharide-based nanocarriers comprising cellulose nanocrystal (CNCs) covalently conjugated with maltoheptaose (MH), serving as an efficient carrier for curcumin (CUR). Curcumin is a natural antibacterial agent and photosensitizer for bacterial photodynamic therapy; however, its practical application is limited by its low solubility, instability, as well as its low bioavailability. Cellulose nanocrystals were extracted from cotton linter, aminated and functionalized with MH via a reductive amination reaction to construct a CNC-based carrier for curcumin delivery. The prepared nanocarrier exhibited an entrapment efficiency of 90% and loading capacity of 6.8%. The in vitro release studies demonstrated pH and light sensitive release behavior with approximately 89% cumulative release at pH 5.4 under light irradiation after 24 h. Antibacterial activity evaluation under blue light irradiation revealed a 20-33% increase in inhibition zone diameters compared to dark conditions, confirming the enhanced antibacterial activity under light irradiation. The findings suggest that the MH-functionalize CNC (CNC-MH) provides an effective platform for curcumin loading and light-responsive antibacterial delivery.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and evaluation of degradable imaging drug loaded embolization microspheres for hepatocellular carcinoma. 可降解显像药物负载肝细胞癌栓塞微球的制备及评价。

IF 3.5 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-10-10 DOI: 10.1080/09205063.2026.2743120

Qi Lai, Ye Fan, Junyi Huang, Ling Huang, Huade Zheng

{"title":"Preparation and evaluation of degradable imaging drug loaded embolization microspheres for hepatocellular carcinoma.","authors":"Qi Lai, Ye Fan, Junyi Huang, Ling Huang, Huade Zheng","doi":"10.1080/09205063.2026.2743120","DOIUrl":"https://doi.org/10.1080/09205063.2026.2743120","url":null,"abstract":"Transarterial chemoembolization (TACE) necessitates the use of embolic agents with intrinsic radiopacity and controlled biodegradability to enhance therapeutic precision. In addressing the limitations inherent in current drug-eluting microspheres (DEMs), this study introduces the development of inherently radiopaque and biodegradable (DOX+Lipiodol) @PLGA @CaCO3 @Alg core-shell microspheres. These microspheres were synthesized using rotating membrane emulsification and surface-induced ion crosslinking, with calcium carbonate serving multiple roles: a solid surfactant for Pickering stabilization, an acid-neutralizing agent, and an alginate shell inducer. The microspheres successfully encapsulated iodine loads, demonstrated by CT values reaching up to 8,000 HU, and contained doxorubicin at 1.53 ± 0.12 wt.%. They exhibited prolonged radiopacity for over 14 days in vivo and showed a pH-responsive drug release pattern, releasing 90% of their payload at pH 5.2 compared to 30% at pH 7.2 over 120 h. The sequential degradation process (alginate → CaCO3 → PLGA) resulted in greater than 60% mass loss within four months, correlating with a reduction in CT attenuation. In rabbit embolization models, the microspheres achieved effective vascular occlusion and induced ischemic necrosis in ears and kidneys. CT tracking was possible without additional contrast agents, and systemic biosafety was confirmed with cell viability exceeding 90%, hemolysis below 1%, and normal hematological and histological profiles. These findings suggest that the microspheres could serve as a clinically translatable platform for image-guided TACE, integrating occlusion, therapy, and monitoring into a cohesive treatment strategy.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.5,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Titanium and polyetheretherketone for spinal fusion cages: a comparative narrative review of material behavior, structural design, and clinical translation. 钛和聚醚醚酮用于脊柱融合器：材料行为、结构设计和临床翻译的比较叙述回顾。

IF 3.5 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-10-09 DOI: 10.1080/09205063.2026.2743125

Hasheminasab, Arian Bazmi, Rojin Hamsianetefagh, Yasemin Tabak, Omid Ashkani, Shahram Mahboubizadeh, Murat Colak, Abdullah Tahir Şensoy

{"title":"Titanium and polyetheretherketone for spinal fusion cages: a comparative narrative review of material behavior, structural design, and clinical translation.","authors":"Hasheminasab, Arian Bazmi, Rojin Hamsianetefagh, Yasemin Tabak, Omid Ashkani, Shahram Mahboubizadeh, Murat Colak, Abdullah Tahir Şensoy","doi":"10.1080/09205063.2026.2743125","DOIUrl":"https://doi.org/10.1080/09205063.2026.2743125","url":null,"abstract":"Cage material selection in spinal fusion requires a trade-off among biological fixation, mechanical compatibility, subsidence resistance, and postoperative imaging. This structured narrative review compares titanium and polyetheretherketone (PEEK) cages across seven domains: osseointegration, modulus matching, endplate load transfer, surface biofunctionality, imaging, additive manufacturing and personalization, and geometry-guided architecture. Peer-reviewed literature indexed in PubMed/MEDLINE, Scopus, and Web of Science was considered from database inception through May 2026, with emphasis on comparative clinical studies, systematic reviews, meta-analyses, and mechanistic studies directly relevant to cage design. Preclinical studies favor porous and additively manufactured titanium for bone-implant integration, but a consistent fusion-rate advantage in anterior cervical discectomy and fusion (ACDF) has not been established. In lumbar surgery, lower subsidence has been reported in selected lateral lumbar interbody fusion cohorts, while results after transforaminal lumbar interbody fusion remain heterogeneous. PEEK retains advantages in radiolucency and intrinsic modulus matching, while surface-modified and porous PEEK can improve biological performance. Subsidence is not determined by chemistry alone; cage footprint, architecture, endplate preparation, fixation, and bone quality remain major modifiers. Current evidence therefore supports procedure and design-specific selection rather than universal replacement of either platform. Long-term comparative data and standardized definitions of fusion and subsidence remain limited.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-22"},"PeriodicalIF":3.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-performance and hemocompatible zeolite-modified PP/PU dialysis membranes for uremic toxin removal. 高性能和血液相容性沸石改性PP/PU透析膜尿毒症毒素去除。

IF 3.5 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-10-09 DOI: 10.1080/09205063.2026.2743129

Zeynep Karahaliloğlu, Baki Hazer

{"title":"High-performance and hemocompatible zeolite-modified PP/PU dialysis membranes for uremic toxin removal.","authors":"Zeynep Karahaliloğlu, Baki Hazer","doi":"10.1080/09205063.2026.2743129","DOIUrl":"https://doi.org/10.1080/09205063.2026.2743129","url":null,"abstract":"The development of hemodialysis membranes capable of simultaneously achieving efficient toxin removal and excellent hemocompatibility remains a major challenge. In this study, a novel dual-layer nanofibrous dialysis membrane was fabricated by combining a solution-electrospun polyurethane-oleic acid-polyethylene glycol (PU-OLE-PEG) top layer with a melt-electrospun polypropylene/zeolite (PP/Zeo) bottom layer. The PU-OLE-PEG layer was designed to enhance hydrophilicity and blood compatibility, while the PP/Zeo layer provided selective adsorption of uremic toxins. The resulting membranes exhibited a molecular weight cut-off of 22-25 kDa, enabling the selective removal of middle-molecular-weight toxins while retaining essential proteins. The 10PP/Zeo-Zeo-ME-PU-OLE-PEG-SE membrane demonstrated the highest adsorption capacity for creatinine (47 ± 5.3 mg g-1) and removal efficiencies of 58 ± 5.6% for urea, 65 ± 6.5% for creatinine, and 71 ± 6.8% for β2-microglobulin (β2-MG). Under in vitro simulated dialysis conditions, high recovery of bovine serum albumin (BSA, 98 ± 9.5%) was achieved, indicating effective preservation of valuable proteins. Hemocompatibility studies revealed hemolysis ratios below 1%, markedly reduced protein adsorption (0.0023 ± 0.004 mg mL-1), low thrombin-antithrombin complex formation, prolonged activated partial thromboplastin time (35.8 ± 3 s), and minimal platelet adhesion. Furthermore, the membranes exhibited excellent cytocompatibility, with cell viabilities exceeding 90%, favorable cell attachment. These findings demonstrate that the synergistic integration of a hemocompatible PU-OLE-PEG layer and a zeolite-containing adsorption layer provides an effective strategy for developing next-generation dialysis membranes with potential applicability in wearable artificial kidney systems.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-30"},"PeriodicalIF":3.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kaolin integrated gellan gum composite sponge for rapid hemostasis. 高岭土集成结冷胶复合海绵快速止血。

IF 3.5 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-10-07 DOI: 10.1080/09205063.2026.2733659

Ashika Suresh, Manju Saraswathy

{"title":"Kaolin integrated gellan gum composite sponge for rapid hemostasis.","authors":"Ashika Suresh, Manju Saraswathy","doi":"10.1080/09205063.2026.2733659","DOIUrl":"https://doi.org/10.1080/09205063.2026.2733659","url":null,"abstract":"Uncontrolled bleeding can result in severe complications, including hemorrhagic shock, hyperthermia, acidosis, coagulopathy, multiple organ failure, and infection. The development of hemostatic agents or devices capable of achieving rapid hemostasis is therefore critical to minimize excessive blood loss during surgical procedures. In this study, a novel kaolin-integrated, gellan gum based composite hemostat sponges were developed via ionic crosslinking mechanism. The established safety and efficacy of kaolin as a hemostatic agent were leveraged in the design, while a composite strategy was employed to address the practical limitations associated with its powdery form. The present study also takes advantages of the water soluble, anionic exopolysaccharide, gellan gum for its excellent biocompatibility, biodegradability, and ability to adapt to physiological conditions. The composite sponges were fabricated using varying ratios of gellan gum and kaolin and evaluated for its hemostatic efficacy. In vitro studies confirmed the non-toxic nature of the sponges, along with their effectiveness in promoting blood clotting.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-21"},"PeriodicalIF":3.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atorvastatin-loaded HPMC/Eudragit composite hydrogel film dressings: physicomechanical properties, sustained release, and wound-repair performance. 载阿托伐他汀HPMC/Eudragit复合水凝胶膜敷料：物理力学性能、缓释和伤口修复性能。

IF 3.5 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-10-06 DOI: 10.1080/09205063.2026.2741661

Muhammad Ali, Muhammad Kamran, Muhammad Rehan Malik, Niamat Ullah, Touseef Nawaz, Adnan Amin

{"title":"Atorvastatin-loaded HPMC/Eudragit composite hydrogel film dressings: physicomechanical properties, sustained release, and wound-repair performance.","authors":"Muhammad Ali, Muhammad Kamran, Muhammad Rehan Malik, Niamat Ullah, Touseef Nawaz, Adnan Amin","doi":"10.1080/09205063.2026.2741661","DOIUrl":"https://doi.org/10.1080/09205063.2026.2741661","url":null,"abstract":"Hydroxypropyl methylcellulose (HPMC)/Eudragit L100 composite hydrogel film dressings were developed for the localized and sustained delivery of atorvastatin to excisional wounds. Solvent-cast formulations containing different HPMC/Eudragit ratios were screened for swelling, mass loss, and tensile strength, and the optimized polymer composition was loaded with 2% (w/w) atorvastatin. Surface morphology and drug-polymer compatibility were examined by scanning electron microscopy and attenuated total reflectance Fourier-transform infrared spectroscopy, respectively. The optimized blank matrix (F3) exhibited a swelling ratio of 79 ± 5.4%, mass loss of 30 ± 2.9%, and tensile strength of 21.71 ± 3.2 MPa. Its atorvastatin-loaded counterpart (F4) showed an interconnected porous morphology and retained the characteristic functional groups of the constituent polymers and drug. Approximately 82% of atorvastatin was released over 24 h. Release data were best described by the Korsmeyer-Peppas model (R2 = 0.994; n = 0.665), indicating anomalous transport. In a full-thickness excisional wound model in Sprague-Dawley rats (n = 6 rats/group), the atorvastatin-loaded hydrogel dressing shows significantly (p < 0.05) faster wound closure and re-epithelialization on day 14 as compared to blank hydrogel film (F3) and standard gauze treated group. Histological analysis showed improved epidermal organization and collagen deposition in ATV loaded hydrogel film treated group. Exploratory molecular docking predicted atorvastatin accommodation within PPARγ and S1PR1 binding pockets, although with weaker scores than the native ligands. These findings support HPMC/Eudragit L100 films as sustained-release wound dressings, with the atorvastatin-loaded formulation showing superior wound-repair performance to the blank matrix and standard gauze, although further mechanistic studies are needed.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-26"},"PeriodicalIF":3.5,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and optimization of HME-based floating dolutegravir extrudates with enhanced drug release and potent anti-viral activity. 具有增强药物释放和抗病毒活性的盐酸多替重力韦漂浮挤出物的设计与优化。

IF 3.5 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-10-06 DOI: 10.1080/09205063.2026.2735699

Manisha S Jain, Akash G R, Buduru Gowthami, Nimbagal Raghavendra Naveen

{"title":"Design and optimization of HME-based floating dolutegravir extrudates with enhanced drug release and potent anti-viral activity.","authors":"Manisha S Jain, Akash G R, Buduru Gowthami, Nimbagal Raghavendra Naveen","doi":"10.1080/09205063.2026.2735699","DOIUrl":"https://doi.org/10.1080/09205063.2026.2735699","url":null,"abstract":"The hot-melt extrusion (HME) technique is quite successful in improving the solubility and bioavailability of poorly water-soluble drugs. Herein, we report the development of optimized dolutegravir floating systems prepared by the HME technique using Design-Expert software. Optimized parameters for floating extrudate included die temperature of 100 °C, screw speed of 58 rpm, and HPMC 15 cPs at 6% w/w, giving a floating lag time of 41 s. The extrudate showed a controlled bi-phasic drug release behavior with 93.1% drug release at 10 h, which is close to the theoretical value. FTIR, XRD, DSC, and SEM-EDS analyses revealed partial amorphization, thermal stability, and uniform drug dispersion in the polymeric matrix. Enhanced dissolution profile and gastroretention characteristics were found in vitro compared with the pure drug. The biological investigation showed improved anti-viral activity, reduced IC50 (1.2 µM vs 4.6 µM), low intracellular viral DNA, and apoptosis selectively on infected cells without any cytotoxic effects on normal cells. To the best of our knowledge, this is the first study showing the application of HME technology for gastroretentive floating systems of dolutegravir.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-38"},"PeriodicalIF":3.5,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green silver nanoparticles-based dissolving microarray patch: characterization,antibacterial activity, controlled release, and in vitro cell migration. 绿色银纳米颗粒溶解微阵列贴片：表征，抗菌活性，控释和体外细胞迁移。

IF 3.5 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-10-05 DOI: 10.1080/09205063.2026.2740596

Teerapat Romgate, Julinthip Puttawong, Chitchamai Ovatlarnporn, Tonghathai Phairatana, Suchera Loyprasert Thananimit

{"title":"Green silver nanoparticles-based dissolving microarray patch: characterization,antibacterial activity, controlled release, and in vitro cell migration.","authors":"Teerapat Romgate, Julinthip Puttawong, Chitchamai Ovatlarnporn, Tonghathai Phairatana, Suchera Loyprasert Thananimit","doi":"10.1080/09205063.2026.2740596","DOIUrl":"https://doi.org/10.1080/09205063.2026.2740596","url":null,"abstract":"The incorporation of silver nanoparticles and an efficient dissolving microarray patch (DMP) has been developed to overcome the limitation of the skin delivery procedure and enhance the penetration of antibacterial agents into infected skin. This study investigated the potential of green-synthesized silver nanoparticles (GAgNPs) as antibacterial agents against wound infections. The fabrication process of DMP incorporating GAgNPs is simple and suitable for large-scale production. The GAgNPs-DMP exhibits antibacterial activity against both Gram-positive and Gram-negative bacteria in a dose-dependent manner, with inhibition observed at approximately 106 CFU/mL. The wound-closure model demonstrated the biocompatibility and improved in vitro cell migration of the developed patches on HDF cells at an optimal dosage of 5.4 µg/mL. GAgNPs-DMP exhibited an initial rapid release phase followed by a slower release phase, with approximately 89% of total silver released by 8 h and a subsequent plateau indicating its potential as an effective drug delivery system for enhanced healing of infected wounds. This finding demonstrates the important biological function of GAgNPs, as evidenced by their antibacterial properties, whereas the polymer matrix is reportedly responsible for migration-related aspects. The synergistic effect of the GAgNPs-DMP presents a promising developed biopolymeric patch for transdermal drug delivery.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-25"},"PeriodicalIF":3.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0