Leila Chodari, Sina Taghilou, Shadi Mohammadpour Asl, Mohammad Ali Ghavimi, Hamid Taghilou, Solmaz Maleki Dizaj, Simin Sharifi
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引用次数: 0
Abstract
Curcumin has antioxidant, anti-inflammatory, and cardiovascular protective effects. This study aimed to develop and evaluate an innovative biodegradable hemostatic gelatinous sponge containing curcumin nanoparticles for use in dentistry. This research investigated the efficacy and safety of this material in both in vitro tests and some clinical settings. The novel sponge was prepared via the freeze-drying method. It was characterized by common approaches. The biocompatibility and biological effects of the new sponge were evaluated in vitro. In the next step, thirty-eight patients who needed dental extraction on two teeth were selected for clinical assessment. The prepared sponge was placed inside the cavity of the experimental group. On the control side, the teeth were extracted normally. All patients were studied for pain, swelling, repair of the extracted site, clot quantity, and the occurrence of dry sockets. Results revealed a porous structure with micro- and nanosized pores and a 12-day degradation period. The produced sponge could absorb blood 38 times its weight. It showed no toxic effect. In the clinical study, pain reduction was larger in the experimental group compared to the control group. The extracted site was normal in terms of repair and clot formation. Finally, there was no dry socket in any of the experimental and control groups. The abovementioned advantages may make the new sponge more effective in tooth extraction and other surgical applications in dentistry.
期刊介绍:
The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels.
The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.