A new developed nano-curcumin containing dental hemostatic material; in vitro and the clinical assessments.

IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL
Leila Chodari, Sina Taghilou, Shadi Mohammadpour Asl, Mohammad Ali Ghavimi, Hamid Taghilou, Solmaz Maleki Dizaj, Simin Sharifi
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引用次数: 0

Abstract

Curcumin has antioxidant, anti-inflammatory, and cardiovascular protective effects. This study aimed to develop and evaluate an innovative biodegradable hemostatic gelatinous sponge containing curcumin nanoparticles for use in dentistry. This research investigated the efficacy and safety of this material in both in vitro tests and some clinical settings. The novel sponge was prepared via the freeze-drying method. It was characterized by common approaches. The biocompatibility and biological effects of the new sponge were evaluated in vitro. In the next step, thirty-eight patients who needed dental extraction on two teeth were selected for clinical assessment. The prepared sponge was placed inside the cavity of the experimental group. On the control side, the teeth were extracted normally. All patients were studied for pain, swelling, repair of the extracted site, clot quantity, and the occurrence of dry sockets. Results revealed a porous structure with micro- and nanosized pores and a 12-day degradation period. The produced sponge could absorb blood 38 times its weight. It showed no toxic effect. In the clinical study, pain reduction was larger in the experimental group compared to the control group. The extracted site was normal in terms of repair and clot formation. Finally, there was no dry socket in any of the experimental and control groups. The abovementioned advantages may make the new sponge more effective in tooth extraction and other surgical applications in dentistry.

新型纳米姜黄素口腔止血材料的研制体外及临床评价。
姜黄素具有抗氧化、抗炎和心血管保护作用。本研究旨在开发和评估一种创新的含有姜黄素纳米颗粒的可生物降解止血凝胶海绵,用于牙科。本研究调查了该材料在体外试验和一些临床环境中的有效性和安全性。采用冷冻干燥法制备了新型海绵。它的特点是采用共同的方法。体外评价了海绵的生物相容性和生物效应。下一步,选择38名需要拔牙的患者进行临床评估。将制备好的海绵置于实验组腔内。对照组拔牙正常。研究了所有患者的疼痛、肿胀、拔牙部位的修复、血块数量和干窝的发生情况。结果表明,该材料具有微孔和纳米孔的多孔结构,降解周期为12 d。这种海绵可以吸收38倍于自身重量的血液。无毒性作用。在临床研究中,实验组的疼痛减轻程度大于对照组。提取部位在修复和血栓形成方面是正常的。最后,实验组和对照组均无干窝。上述优点可能使新型海绵在拔牙和其他牙科手术应用中更加有效。
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来源期刊
Journal of Biomaterials Science, Polymer Edition
Journal of Biomaterials Science, Polymer Edition 工程技术-材料科学:生物材料
CiteScore
7.10
自引率
5.60%
发文量
117
审稿时长
1.5 months
期刊介绍: The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels. The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.
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