Journal of Biomaterials Science, Polymer Edition最新文献

{"title":"Multifunctional nanocomposite with stage-responsive behavior for wound healing.","authors":"Yingyu Hou, Kejian Wu, Xinyi Zhang, Wenlong Duan, Xinyu Wang, Chengyue Zhu, Qingbin He, Lining Wang","doi":"10.1080/09205063.2026.2740602","DOIUrl":"https://doi.org/10.1080/09205063.2026.2740602","url":null,"abstract":"<p><p>Chronic wounds, particularly refractory diabetic ulcers, typically fail to heal due to a self-perpetuating inflammatory state driven by persistent bacterial infection, severe oxidative stress, and impaired microvascular regeneration. Conventional static dressings cannot accommodate the spatiotemporal, multiphase complexity of tissue repair. Here, a stage-responsive hierarchical nanocomposite (SNF@GQDs@Arg) was engineered by covalently anchoring graphene quantum dots (GQDs) onto radially porous silica nanoflowers (SNF), followed by surface adsorption of L-arginine (L-Arg). The resulting platform coordinates wound repair through an integrated tripartite-physical, catalytic, and metabolic-cascade. In the initial hemostatic phase, the high-aspect-ratio topography of SNF enables rapid wound closure <i>via</i> a non-covalent nano-bridging effect. During the inflammatory phase, the immobilized GQDs act as peroxidase-mimicking nanozymes, converting pathological hydrogen peroxide (H₂O₂) into bactericidal hydroxyl radicals (·OH) to eradicate biofilms while simultaneously scavenging excess free radicals to resolve the reactive oxygen species (ROS) paradox. Concurrently, the sustained release of L-Arg replenishes the substrate pool for macrophage inducible nitric oxide synthase (iNOS), restoring physiological nitric oxide (NO) bioavailability. This metabolic intervention drives pro-inflammatory M1-to-reparative M2 phenotype transition, upregulates CD31 and VEGF expression to stimulate angiogenesis, and promotes organized collagen deposition. In a murine infected full-thickness skin defect model, SNF@GQDs@Arg markedly accelerated wound closure, suppressed local inflammation, and enhanced tissue remodeling quality without inducing systemic toxicity. By synchronizing functional bioactivity with the endogenous repair rhythm, this platform provides a microenvironment-adaptive paradigm for refractory chronic wound therapy.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-22"},"PeriodicalIF":3.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezoelectric-bioactive coupling of PVDF and hydroxyapatite for enhancing the interfacial bioactivity and osteogenic potential of the 3D-printed polyurethane scaffolds.","authors":"Yimeng Chen, Xu Dong, Xingping Zhou","doi":"10.1080/09205063.2026.2750332","DOIUrl":"https://doi.org/10.1080/09205063.2026.2750332","url":null,"abstract":"<p><p>The shortage and high cost of autologous bone grafts have created an urgent need to the development of biocompatible materials for bone defect repair. Bone is a natural piezoelectric tissue that generates electrical stimulation to induce osteogenic differentiation. However, most biodegradable polymers lack inherent piezoelectric properties, making the design of controllably degradable piezoelectric biomaterials particularly significant. In this work, poly(ε-caprolactone) (PCL) was used as a raw material to synthesize a polyurethane (PU)-based bio-ink consisting of polyvinylidene fluoride (PVDF) and hydroxyapatite (HA) <i>via</i> a one-step method. Personalized composite scaffolds (PU/PVDF/HA) were then fabricated by extrusion-based 3D printing. Characterization results from FTIR, XRD, water contact angle, and degradation tests confirmed the successful formation of PU/PVDF/HA composite scaffolds and demonstrated that the incorporation of HA effectively enhanced the bioactivity of the composite material with pronounced piezoelectric properties, suggesting potential relevance for osteogenic applications. Further, the PU/PVDF/HA15 group (containing 15 wt% HA and 5 wt% PVDF) had a good biocompatibility, which was clearly reflected by CCK-8 detection and live/death fluorescence imaging compared with the other groups. Overall, the synergistic action of piezoelectricity and bioactivity in PU/PVDF/HA scaffolds improved the physicochemical characteristics of the material-tissue interface, and then promoted the osteogenic activity. This study provides experimental evidence supporting the feasibility of integrating piezoelectric functionality and bioactivity into polymer-based scaffolds for bone tissue engineering.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.5,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable polycaprolactone/flexible nano-liposome/propolis nanofibers for enhanced biocompatibility and antibacterial activity.","authors":"Hua-Wei Chen, Chun-Hung Cheng, Yi-Lin Chen, Yu-Hsiang Yu, Su-Der Chen, Yi-An Hou, Wei-Ting Chen","doi":"10.1080/09205063.2026.2750329","DOIUrl":"https://doi.org/10.1080/09205063.2026.2750329","url":null,"abstract":"<p><p>This study employs electrospinning technology to develop biodegradable polycaprolactone (PCL) nanofibers integrated with flexible nano-liposomes and propolis (PCL/F-Lip/Pro). The investigation encompassed the assessment of porosity, contact angle, equilibrium water content, cell viability, and antimicrobial activity of the PCL/F-Lip/Pro nanofibers, considering various PCL and propolis concentrations, flow rates, and applied voltage parameters. Regarding biocompatibility, cytotoxicity assays indicated that PCL/F-Lip/Pro scaffolds with 1 wt% propolis exhibited the highest cell viability (96.0%), significantly surpassing that of PCL alone. However, higher propolis concentrations resulted in a slight reduction in cell viability, likely due to the inhibitory effects of caffeic acid and chlorogenic acid derivatives present in propolis. As the propolis concentration increased from 0 wt% to 10 wt%, the equilibrium water content (EWC) of the PCL/F-Lip/Pro scaffolds significantly increased from 133 ± 32.2% to 1567 ± 60.11%, surpassing the YY0148-2006 medical dressing standard of 150%. This enhancement in water absorption capacity is attributed to the hydroxyl groups in the phenolic compounds. The zone of inhibition for PCL/F-Lip/Pro scaffolds against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> increased from 0 mm to 66.4 ± 1.6 mm and from 0 mm to 54.8 ± 1.4 mm, respectively, as the propolis concentration rose from 0 wt% to 10 wt%. These results highlight propolis's significant antibacterial effect, attributed to its aromatic acids, phenolics, and flavonoids in propolis, which disrupt cell membranes and bacterial cytoplasm. In conclusion, the PCL/F-Lip/Pro scaffold developed in this study offers a balanced combination of porosity, hydrophilicity, biocompatibility, and antibacterial activity, rendering it a promising candidate for advanced wound care applications.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-18"},"PeriodicalIF":3.5,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monolithic tissue sealant membrane with covalently‑anchored NHS‑activated gelatin adhesive moieties on flexible PLCL substrate: preparation, characterization and biological performance.","authors":"Anyan Yao, Zhixin Zhang, Xiuyan Gao, Hongxia Zheng, Xiaomin Ren, Weili Wang, Quan Wang","doi":"10.1080/09205063.2026.2746385","DOIUrl":"https://doi.org/10.1080/09205063.2026.2746385","url":null,"abstract":"<p><p>Clinically available tissue sealant membranes are limited by high swelling, poor flexibility, insufficient adhesion and high cost, restricting their use in complex surgeries. Herein, a novel monolithic embedded tissue sealant membrane (IIIb) was constructed <i>via</i> UV‑initiated copolymerization. In this optimized formulation, NHS‑modified gelatin adhesive moieties were covalently anchored onto one side of flexible PLCL‑containing substrate, rather than simple physical lamination of two independent films (control sample IIIa prepared by method a). Although exhibiting a two‑layer‑like appearance, the resulting IIIb membrane forms an integral entity to suppress interfacial delamination. The composite membrane was prepared by sequential coating followed by UV photocrosslinking, and its chemical structure, morphology, adhesion, mechanics, swelling, degradation and biosafety were systematically evaluated. The optimized membrane showed an adhesive strength of 8.15 KPa, tensile strength of 4.9 MPa, elongation at break of 116.7%, and a low 72 h swelling ratio of 1.1%. Its degradation time was tunable from 4 to 36 weeks by regulating PLCL content to match soft tissue healing. <i>In vitro</i> and <i>in vivo</i> tests verified good cytocompatibility, hemocompatibility and negligible systemic toxicity with mild foreign body reaction. The membrane achieved a burst pressure of 11.5 ± 1.2 kPa in an <i>ex vivo</i> porcine stomach perforation model, satisfying clinical sealing demands. This membrane overcomes the deficiencies of commercial counterparts and holds great potential for clinical tissue sealing.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.5,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional pDA@MXene-enriched silk fibroin/PLLA nanofibrous scaffold with local piezoresponse for neural tissue engineering.","authors":"Özge Lalegül-Ülker, Şükran Şeker, Burcu Bayramli-Öner, Ekin Efe, Yaşar Murat Elçin","doi":"10.1080/09205063.2026.2743126","DOIUrl":"https://doi.org/10.1080/09205063.2026.2743126","url":null,"abstract":"<p><p>Neural tissue engineering requires functional scaffolds that provide structural support while presenting biomimetic physicochemical cues to cells. Incorporating stimulus-responsive functionality into electrospun scaffolds has emerged as a promising strategy for developing next-generation neural tissue engineering platforms. In this study, a polydopamine (pDA)@MXene-enriched silk fibroin/poly(L-lactic acid) (SF/PLLA) electrospun nanofibrous scaffold was developed as a multifunctional platform for neural tissue engineering. Structural and physicochemical characterization verified the formation of Ti₃C₂ MXene from the Ti₃AlC₂ MAX precursor, successful pDA functionalization, and effective vacuum-assisted incorporation of pDA@ Ti₃C₂ MXenes onto the SF/PLLA nanofibrous scaffold. PFM analysis revealed a detectable local electromechanical response, consistent with the piezo-responsive characteristics of the developed scaffold. Moreover, pDA@MXene incorporation enhanced the surface hydrophilicity, as evidenced by the decrease in water contact angle from 73.49 ± 0.73° to 47.38 ± 0.6°. In-vitro experiments showed that the developed scaffold supported PC-12 cell metabolic activity throughout the culture period. SEM observations revealed effective attachment and close cell-nanofiber interactions. Under NGF-treated conditions, following a commonly used 7-day PC12 differentiation period, <i>β</i>III-tubulin-positive cells with neuron-like morphological features were observed on the pDA@MXene-enriched scaffold, supporting its compatibility with NGF-induced neuronal-like phenotypic development. Collectively, the pDA@MXene-enriched scaffold exhibited enhanced surface hydrophilicity, favorable mechanical properties, local electromechanical responsiveness, and cytocompatibility, supporting its potential as a multifunctonal platform for further investigation in neural tissue engineering.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-19"},"PeriodicalIF":3.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced alginate engineering strategies toward next-generation precision orthopedics.","authors":"Zhiping Chen, Shan Huang, Lixian Li, Yankui Zhai, Ahmad, Li Li, Yanzhi Liu","doi":"10.1080/09205063.2026.2741660","DOIUrl":"https://doi.org/10.1080/09205063.2026.2741660","url":null,"abstract":"<p><p>The rising clinical demand for treating musculoskeletal defects necessitates viable alternatives to traditional bone grafting. Alginate, a naturally derived polysaccharide, has become a leading bioink for 3D bioprinting owing to its abundance, rapid ionic crosslinking, and scalable manufacturing. Yet, intrinsic drawbacks-poor cell adhesivity, unpredictable degradation kinetics, and overall low bioactivity-continue to impede clinical translation. Advances in chemical modification and mechanical reinforcement have begun to reprogram alginate into dynamic extracellular matrix mimics with enhanced osteogenic guidance. These structural modifications are further complemented by sophisticated fabrication techniques such as ion-exchange-mediated stiffness gradients, multi-material extrusion, and 4D printing. Concurrently, the design of next-generation bioinks is transitioning from passive scaffolding to active immunomodulation to drive endogenous regeneration. Yet, clinical translation remains constrained by critical challenges, notably ensuring long-term <i>in vivo</i> stability, matching scaffold degradation kinetics with de novo tissue formation, and navigating the complex manufacturing and regulatory requirements for combination products. By evaluating advanced alginate engineering strategies, with a specific focus on patient-specific, immunomodulatory, and dynamically adaptive grafts, as well as its emerging applications in organoid culture, this review serves as a valuable reference to guide the future development and clinical translation of next-generation alginate-based biomaterials.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-40"},"PeriodicalIF":3.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From binary bottlenecks to ternary synergy: precise ionic microenvironment regulation in PCL-based electrospun scaffolds for bone repair.","authors":"Pei Feng, Wen Shen","doi":"10.1080/09205063.2026.2744920","DOIUrl":"https://doi.org/10.1080/09205063.2026.2744920","url":null,"abstract":"<p><p>Polycaprolactone (PCL) electrospun scaffolds are widely investigated for bone tissue engineering because they mimic the fibrous architecture of the extracellular matrix. However, pristine PCL exhibits insufficient bioactivity and a degradation rate poorly matched to bone regeneration. Binary composites, including PCL/bioactive glass and PCL/tantalum scaffolds, have been developed to address these limitations but face two common bottlenecks. The first is a \"loading paradox\": excessive nanofiller incorporation causes aggregation, poor interfacial compatibility, and mechanical deterioration. The second is a \"signaling gap\": limited, predominantly static, or poorly coordinated cues cannot meet the changing biological demands of bone repair. This review examines the rationale and research progress behind the transition from binary modification to ternary synergistic strategies. Introducing a third functional component may improve filler dispersion, enable functional enhancement at lower individual loading levels, and integrate complementary biological signals. In particular, coordinated multi-ion delivery may reproduce aspects of the native bone \"ionic cocktail,\" supporting osteogenesis, angiogenesis, and immune microenvironment regulation. Nevertheless, ternary systems still lack systematic criteria for selecting compatible components and face difficulties in matching ion release and scaffold degradation to the stages of bone regeneration. Future directions include AI-assisted rational design, 4D-printed responsive materials, precise spatiotemporal ion delivery, and personalized manufacturing. Together, these strategies may advance PCL-based scaffolds from broad synergistic enhancement toward precise ionic microenvironment regulation for complex bone defects.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-42"},"PeriodicalIF":3.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A549 cell membrane-camouflaged Mn²⁺-doped Prussian blue/polydopamine nanoparticles for light-responsive chlorin e6 delivery.","authors":"Siyuan An, Shuang Liu, Yue Gao, Jiahao Zou, Guoshi Zhang, Xueying Yan","doi":"10.1080/09205063.2026.2744779","DOIUrl":"https://doi.org/10.1080/09205063.2026.2744779","url":null,"abstract":"<p><p>A549 cell membrane-camouflaged Mn²⁺-doped Prussian blue/polydopamine-chlorin e6 nanoparticles (MnPB-PDA-Ce6@CCM) were developed as a biomimetic, light-responsive delivery system. MnPB nanoparticles were modified with polydopamine, conjugated with chlorin e6 (Ce6), and coated with A549 cell membranes by membrane extrusion. The formulation was optimized using a Box-Behnken design. Under the optimized conditions, MnPB-PDA-Ce6 exhibited a drug loading of 14.16 ± 0.42%, an encapsulation efficiency of 80.13 ± 0.25%, and a particle size of 38.25 ± 0.56 nm. Membrane coating increased the particle size to 50.26 ± 0.33 nm and produced a polydispersity index of 0.181 and a zeta potential of -25.97 ± 1.8 mV. Complementary physicochemical and protein analyses supported nanoparticle assembly and retention of A549 membrane-associated proteins. MnPB-PDA-Ce6@CCM showed enhanced Ce6 release under acidic conditions and 808 nm irradiation, photothermal heating under 808 nm irradiation, and reactive oxygen species generation under 660 nm irradiation. Compared with uncoated nanoparticles, MnPB-PDA-Ce6@CCM showed increased uptake by A549 cells and reduced uptake by RAW264.7 macrophages. Following laser irradiation, the coated formulation produced the greatest inhibition of A549 cells, with an IC₅₀ of 1.68 μg/mL. In rats, MnPB-PDA-Ce6@CCM altered the pharmacokinetic behavior of Ce6 and delayed its clearance. These findings support further evaluation of this biomimetic platform for light-responsive Ce6 delivery.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-33"},"PeriodicalIF":3.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of drug distributions within electrospun architectures on icariin sustained release from polycaprolactone nanofibers.","authors":"Abdurohman Mengesha Yessuf, Tibebu Shiferaw Kassa, Yaxing Duan, Paulos Tadesse Shibeshi, Qidong Zhang, Yong Liu","doi":"10.1080/09205063.2026.2746382","DOIUrl":"https://doi.org/10.1080/09205063.2026.2746382","url":null,"abstract":"<p><p>The fabrication architecture of electrospun drug-loaded nanofibers is pivotal in regulating drug distribution and release kinetics. However, systematic comparisons of electrospinning-based drug-loading strategies under identical experimental conditions remain scarce. In this study, four electrospinning architectures, including blend electrospinning, electrospraying, coaxial (core-shell), and triaxial electrospinning, were compared to elucidate how structural configuration influences the morphology, mechanical behavior, and release kinetics of icariin -loaded polycaprolactone nanofibers. Electrospun membranes were fabricated using the same polymer matrix, nominal drug loading, and processing conditions to ensure a direct comparison between architectures. Morphological characterization showed that electrosprayed fibers had rougher surfaces and larger average fiber diameters, whereas Core-sheath and tri-chamber fibers displayed smoother, more uniform morphologies. In a single release study per architecture, multilayer architectures showed a lower initial burst release, with tri-chamber nanofibers exhibiting the lowest initial burst (approximately 3.7%) and a sustained cumulative release of approximately 25% over 168 h. Kinetic modeling showed that the tri-chamber l architecture had the strongest agreement with the Higuchi model (R² = 0.9898) and the highest zero-order correlation (R² = 0.8747), indicating diffusion-controlled release from a multilayer reservoir structure. In contrast, the electrospinning-electrospraying blend showed faster release profiles dominated by surface-associated drug diffusion. These findings suggest that electrospinning architecture is a key determinant of drug encapsulation stability and release behavior, a trend that requires confirmation with replicate batches. The present work establishes a rational framework for selecting electrospinning strategies to engineer sustained-release nanofibrous drug-delivery systems for regenerative medicine and localized therapeutic applications.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-25"},"PeriodicalIF":3.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication and characterization of cross-linked polymer hydrogel encapsulated with Nisin for wound dressing applications.","authors":"Aarzoo Sinha, Natalie Kavya, Subikshaa Veluswamy Senthilkumaran, Krithika Senthilkumaran, Nithesh Jerome, Rupachandra Saravankumar","doi":"10.1080/09205063.2026.2741650","DOIUrl":"https://doi.org/10.1080/09205063.2026.2741650","url":null,"abstract":"<p><p>Bioactive peptides like Nisin are gaining significant attention for their wound-healing and immunomodulatory properties. Hydrogels, with their high-water content resembling the natural extracellular matrix, provide a moist environment that supports cell migration, proliferation, and autolytic debridement. In this study, we developed a Nisin-encapsulated oxidized sodium alginate-collagen hydrogel through chemical crosslinking for wound-dressing applications. The ratio of polymers and Nisin was optimized based on swelling capacity and porosity, with the 5% formulation exhibiting the best performance. Characterization using SEM and XRD confirmed hydrogel formation by revealing larger pore sizes and reduced diffraction peaks, while MTT assays demonstrated a cell viability of 95.6% at 0.03 mM Nisin. The results further indicated that Nisin encapsulation enhanced the antioxidant and anti-inflammatory properties of the hydrogel, supporting its potential as an effective wound-dressing material. <i>In vivo</i> studies using a full-thickness wound rat model showed that the hydrogel promoted wound healing effectively. Acute dermal toxicity assessed using H&E staining revealed no toxicity in skin tissues at a dosage of 200 mg/kg BW. Furthermore, after 14 days of treatment, the residual wound area was 5% in the hydrogel-treated group, whereas the control group retained 30% of the original wound area. The treatment also significantly increased the expression of IL-10 (an anti-inflammatory cytokine) and decreased TNF-α (a pro-inflammatory cytokine) on both day 7 and day 14. These findings collectively highlight the strong potential of hydrogel for advanced wound-care applications.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-30"},"PeriodicalIF":3.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}