Journal of Biomaterials Science, Polymer Edition最新文献

Prospects of injectable hydrogels for bone tissue engineering applications. 可注射水凝胶在骨组织工程中的应用前景。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-05-01 Epub Date: 2025-08-14 DOI: 10.1080/09205063.2025.2545091

Gajanan Arbade, Sayali Chandekar, Nikita Shinde, Pradnya Salve, Shivaji Kashte

引用次数: 0

Lipidic nanocarriers for the treatment of schizophrenia: progress and prospects of solid lipid nanoparticles and nanostructured lipid carriers. 治疗精神分裂症的脂质纳米载体：固体脂质纳米颗粒和纳米结构脂质载体的进展和前景。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-05-01 Epub Date: 2025-09-10 DOI: 10.1080/09205063.2025.2554131

Karan A Maniar, Bindu Kumari Nagendra Yadav, Shreeraj Shah

{"title":"Lipidic nanocarriers for the treatment of schizophrenia: progress and prospects of solid lipid nanoparticles and nanostructured lipid carriers.","authors":"Karan A Maniar, Bindu Kumari Nagendra Yadav, Shreeraj Shah","doi":"10.1080/09205063.2025.2554131","DOIUrl":"10.1080/09205063.2025.2554131","url":null,"abstract":"Schizophrenia is a persistent and incapacitating neuropsychiatric condition that presents considerable obstacles regarding pharmacological administration and therapeutic effectiveness. Lipidic nanocarriers, including Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs), have emerged as effective drug delivery vehicles for enhancing the bioavailability, stability, and controlled release of antipsychotic medicines. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have several benefits, such as improved drug loading capacity, less systemic adverse effects, and superior efficacy in traversing the blood-brain barrier compared to conventional formulations. This study examines advancements in the development of solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) for schizophrenia therapy, emphasising their potential to improve cerebral medication delivery, extend drug release duration, and decrease administration frequency. Moreover, the essay discusses the difficulties related to the scaling of lipid-based nanocarriers, regulatory obstacles, long-term safety concerns, and the necessity for personalised treatment strategies. Notwithstanding the encouraging results in preclinical models, other challenges persist, including the necessity for enhanced formulation methodologies, safety validation, and regulatory clarity. Future possibilities entail the advancement of personalised nanomedicine platforms and intelligent nanocarriers that respond to particular stimuli, perhaps transforming schizophrenia treatment through more targeted, efficient, and individualised treatments.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1327-1351"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication, characterization and in vitro evaluation of PCL/PVA nanofibers loaded with docetaxel in breast cancer cells. 多西紫杉醇负载PCL/PVA纳米纤维在乳腺癌细胞中的制备、表征及体外评价

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-05-01 Epub Date: 2025-08-29 DOI: 10.1080/09205063.2025.2551922

Zeynab Zamanzade, Shohreh Fahimirad, Maryam Darvish

{"title":"Fabrication, characterization and in vitro evaluation of PCL/PVA nanofibers loaded with docetaxel in breast cancer cells.","authors":"Zeynab Zamanzade, Shohreh Fahimirad, Maryam Darvish","doi":"10.1080/09205063.2025.2551922","DOIUrl":"10.1080/09205063.2025.2551922","url":null,"abstract":"Breast cancer ranks as the second highest cause of mortality among women, and docetaxel (DTX) is a potent anticancer agent whose therapeutic effects can be optimized using nanofibers (NFs)-based drug delivery systems (DDSs). In this study, DTX-loaded NFs were fabricated using polycaprolactone (PCL) and polyvinyl alcohol (PVA) via electrospinning. Scanning electron microscopy (SEM) revealed smooth, bead-free morphology with random fiber orientation. Fourier-transform infrared spectroscopy (FTIR) confirmed successful DTX loading. In vitro drug release assays revealed an initial burst release of approximately 72% within the first 24 h, followed by sustained release over 4 days, resulting in a total of 90% drug release over 7 days. Cytotoxicity studies showed DTX-NFs induced a significant reduction in MCF-7 cell viability, with a 60% decrease in cell viability compared to the control group and a 40% increase compared to free DTX at the same concentration after 24 h. DTX-NFs reduced cell migration by 45% and colony formation decreased by 50% compared to the free DTX treatment. In conclusion, DTX-loaded PCL/PVA NFs demonstrated promising anticancer efficacy, sustained drug release and reduced migration and colony formation in MCF-7 cells, making them a potential strategy for postoperative local chemotherapy and prevention of breast cancer recurrence.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1260-1281"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in biodegradable biosensors for biomedical and environmental applications. 生物医学和环境应用中可生物降解生物传感器的最新进展。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-05-01 Epub Date: 2025-09-10 DOI: 10.1080/09205063.2025.2554132

Haya Akkad, Kaan Keçeci, Esma Ahlatcıoğlu Özerol

{"title":"Recent advances in biodegradable biosensors for biomedical and environmental applications.","authors":"Haya Akkad, Kaan Keçeci, Esma Ahlatcıoğlu Özerol","doi":"10.1080/09205063.2025.2554132","DOIUrl":"10.1080/09205063.2025.2554132","url":null,"abstract":"Biodegradable biosensors represent a transformative advancement in sustainable sensing technology, offering an environmentally friendly and biocompatible alternative to traditional sensors. This review examines recent advancements, material innovations, degradation mechanisms, and application areas of biodegradable biosensors within the biomedical and environmental sectors. Natural and synthetic biodegradable polymers, such as chitosan, silk fibroin, alginate, PLA, PLGA, and PVA, are assessed for their functional contributions to sensing platforms. Applications, ranging from implantable cardiovascular and neural sensors to soil nutrient monitors and gas detectors, are detailed with corresponding performance data. Although challenges related to signal stability, integration, and long-term operation persist, future research emphasizes multifunctionality, wireless communication, energy autonomy, and AI-driven diagnostics. This review highlights the potential of biodegradable biosensors to transform health monitoring, environmental assessment, and personalized medicine by aligning technological functionality with principles of sustainability.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1352-1383"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparison of UHMWPE-based materials for joint replacement liners by various manufacturers. 不同厂家关节置换衬垫用uhmwpe基材料的比较。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-05-01 Epub Date: 2025-09-08 DOI: 10.1080/09205063.2025.2551925

Dolguyaana Sidorova, Nikolai Sleptsov, Aleksandr Spiridonov, Afanasii Dyakonov, Ivan Troev, Gennadiy Palshin, Okhlopkova Aitalina

引用次数: 0

Gossypol-based nanocarriers for cancer treatment: advances and future perspectives. 基于棉酚的癌症治疗纳米载体：进展和未来展望。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-05-01 Epub Date: 2025-09-11 DOI: 10.1080/09205063.2025.2554978

Sambhavi Swarn, Ali M Alaseem, Sachin Sharma, Arghya Paria, Bhupendra G Prajapati, Glowi Alasiri, Sonam M Gandhi, Devesh U Kapoor

{"title":"Gossypol-based nanocarriers for cancer treatment: advances and future perspectives.","authors":"Sambhavi Swarn, Ali M Alaseem, Sachin Sharma, Arghya Paria, Bhupendra G Prajapati, Glowi Alasiri, Sonam M Gandhi, Devesh U Kapoor","doi":"10.1080/09205063.2025.2554978","DOIUrl":"10.1080/09205063.2025.2554978","url":null,"abstract":"Gossypol, a polyphenolic aldehyde derived from cotton plants, has emerged as a potent natural anticancer agent due to its ability to modulate multiple cellular pathways, including apoptosis, angiogenesis, and cell cycle arrest. Despite its promising therapeutic potential, the clinical application of gossypol has been limited by poor aqueous solubility, rapid metabolism, systemic toxicity, and low bioavailability. Nanocarrier-based drug delivery systems offer an innovative strategy to overcome these challenges, enabling targeted delivery, enhanced stability, and reduced off-target effects. This review comprehensively discusses the pharmacological profile of gossypol, its mechanisms of anticancer action, and the limitations associated with its conventional use. The review explores a diverse array of nanocarrier platforms such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, dendrimers, micelles, and hybrid systems that have been engineered to improve gossypol's therapeutic index in both in vitro and in vivo models. Furthermore, the review addresses the formulation challenges, toxicity concerns, and regulatory barriers associated with nanocarrier development. Finally, the review highlights emerging trends, including exosome-mediated delivery and biomimetic systems, and discusses the future of personalized nanomedicine and translational pathways for clinical adoption. Gossypol-loaded nanocarriers represent a promising frontier in cancer therapy, potentially bridging the gap between natural product efficacy and clinical applicability.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1384-1415"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

QbD-optimized curcumin-lignin nanoparticle spray for targeted wound infection therapy against Escherichia coli and Mycobacterium smegmatis. qbd优化的姜黄素-木质素纳米颗粒喷雾剂对大肠杆菌和耻垢分枝杆菌伤口感染的靶向治疗。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-05-01 Epub Date: 2025-09-04 DOI: 10.1080/09205063.2025.2551917

Muskan Goyal, Naman Batra, Harish Vishkarma, Lubna Siddiqui, Saurabh Mittal, Garima Sharma, Vartika Mathur, Sushama Talegaonkar

{"title":"QbD-optimized curcumin-lignin nanoparticle spray for targeted wound infection therapy against Escherichia coli and Mycobacterium smegmatis.","authors":"Muskan Goyal, Naman Batra, Harish Vishkarma, Lubna Siddiqui, Saurabh Mittal, Garima Sharma, Vartika Mathur, Sushama Talegaonkar","doi":"10.1080/09205063.2025.2551917","DOIUrl":"10.1080/09205063.2025.2551917","url":null,"abstract":"Chronic wounds infected with multidrug-resistant bacteria pose a significant therapeutic challenge, requiring biocompatible and effective interventions. This study presents a novel lignin-based nanoparticle spray for the localized delivery of curcumin, a natural anti-inflammatory and antimicrobial compound. Lignin, a sustainable polyphenolic biopolymer with inherent antioxidant and antimicrobial activities, was used both as a carrier and functional agent. Curcumin-loaded lignin nanoparticles (CLLNPs) were synthesized using a dialysis-based solvent displacement method and optimized through a Quality by Design approach. These nanoparticles were incorporated into a Eudragit-L100-based film-forming spray for targeted skin application. The optimized CLLNPs exhibited a mean particle size of 119.2 ± 2.1 nm, PDI of 0.167, zeta potential of -21.5 mV, and high encapsulation efficiency (97.58 ± 0.67%). The spray dried quickly within 60 s, showed good film uniformity, mechanical stability, and a skin-compatible pH of 6.21. In vitro release followed Higuchi kinetics, with 88.76% curcumin released within 6 h. Ex vivo skin permeation studies demonstrated enhanced drug penetration (165.62 µg/cm2/h), and CLSM confirmed uniform, deep nanoparticle penetration into skin layers. The formulation exhibited strong antibacterial activity against both Gram-negative Escherichia coli and Gram-positive Mycobacterium smegmatis, along with potent antioxidant activity (91.85% DPPH scavenging at 500 µg/mL). Together, these findings highlight the potential of lignin-based nanocarriers to offer a synergistic, sustainable, and patient-friendly approach to wound healing and infection control, aligning with the goals of personalized medicine.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1227-1259"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspirin-loaded thermo-sensitive chitosan-sodium alginate hydrogel for the prevention of intrauterine adhesions. 载阿司匹林热敏壳聚糖-海藻酸钠水凝胶预防宫内粘连。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-04-29 DOI: 10.1080/09205063.2026.2651261

Hainong Ma, Yanyan Yao, Li Gao, Xiying Yang, Wenzhu Zhang, Xu Song

{"title":"Aspirin-loaded thermo-sensitive chitosan-sodium alginate hydrogel for the prevention of intrauterine adhesions.","authors":"Hainong Ma, Yanyan Yao, Li Gao, Xiying Yang, Wenzhu Zhang, Xu Song","doi":"10.1080/09205063.2026.2651261","DOIUrl":"https://doi.org/10.1080/09205063.2026.2651261","url":null,"abstract":"Intrauterine adhesions (IUAs) are fibrotic bands that form within the uterine cavity as a result of aberrant basal-endometrium repair following trauma or infection. Although several treatment modalities are available, recurrent adhesion remains frequent, and no preventive strategy has proven consistently reliable. In this work, we developed a β-Glycerophosphate-Chitosan/Sodium Alginate (β-GP-CS/SA) thermosensitive hydrogel incorporating aspirin (ASA) as a model anti-inflammatory compound. When exposed to physiological temperature (37 °C), the sol underwent gelation within approximately 5 min, forming an elastic gel (≈11.2 kPa) with an interconnected porous microarchitecture. The material underwent progressive biodegradation, losing nearly 87% of its mass in 14 days, while releasing about 60% of its ASA content in a sustained manner, indicating a release mechanism governed not solely by matrix erosion but also by diffusion and drug-polymer interactions. In vitro studies confirmed minimal cytotoxicity, suppression of fibrogenic markers (Collagen I and α-SMA), enhancement of VEGF expression, and promotion of stromal-cell migration. In vivo, implantation of the ASA-loaded gel markedly attenuated adhesion formation, preserved endometrial morphology, reduced stromal fibrosis, and produced no hepatic or renal lesions. These findings identify a biodegradable and thermoresponsive hydrogel that unites physical isolation with prolonged anti-inflammatory and regenerative actions, providing a rational basis for clinical prevention of IUAs.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-22"},"PeriodicalIF":3.6,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silk fibroin reinforced decellularized porcine pericardial patch with superior strength, biocompatibility, and non-toxicity as a regenerative replacement for cardiovascular applications. 丝素蛋白增强脱细胞猪心包贴片，具有较强的强度、生物相容性和无毒性，可作为心血管应用的再生替代物。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-04-22 DOI: 10.1080/09205063.2026.2659100

Jesna Puthiya Veettil, Devika Sasikumar Lolitha, Sreedevi V S, Umashankar Payanam Ramachandra

{"title":"Silk fibroin reinforced decellularized porcine pericardial patch with superior strength, biocompatibility, and non-toxicity as a regenerative replacement for cardiovascular applications.","authors":"Jesna Puthiya Veettil, Devika Sasikumar Lolitha, Sreedevi V S, Umashankar Payanam Ramachandra","doi":"10.1080/09205063.2026.2659100","DOIUrl":"https://doi.org/10.1080/09205063.2026.2659100","url":null,"abstract":"Decellularized bovine and porcine pericardia are the most extensively used biological substitutes in clinical settings as self-regenerating replacements for treating cardiovascular anomalies. Despite advancements, these substitutes undergo early deterioration and degeneration if not crosslinked. The chemical crosslinking of these scaffolds, aimed at addressing their weak mechanical strength, hinders their long-term performance and regenerative efficacy. The present method describes the systematic evaluation of an alkaline-catalyzed, low-temperature mediated citric acid crosslinking strategy to incorporate silk fibroin (SF) for enhancing the biomechanical properties and stability of decellularized porcine pericardia (DPP) . Decellularization was performed using the tridecyl alcohol (ATE) method. Silk fibroin reinforced porcine pericardium (SFDPP) was systematically analyzed for successful incorporation of SF using histology, Confocal Raman microscopy, and SEM. Thermal analysis, biomechanical properties, suturability, and resistance to collagenase degradation has demonstrated increased strength and durability. In vitro cytocompatibility and toxicological studies further confirmed that SFDPP is biocompatible and non-toxic, making it suitable for cardiovascular applications. Rat subcutaneous implantation has proven SFDPP to be associated with significantly reduced inflammation and mineralization compared to the commercially available SJM Biocor pericardial patch. Results from rat abdominal wall defect and pig aortic vascular defect models demonstrated that SFDPP patch promoted structural restoration by site-appropriate constructive remodelling in both the defects. All these evidences confirmed its efficacy as a potential patch for treating cardiovascular defects.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.6,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanically reinforced and bioactive core-shell nanofibrous membranes loaded with astragaloside IV for guided bone regeneration. 机械增强和生物活性核壳纳米纤维膜装载黄芪甲苷引导骨再生。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2026-04-16 DOI: 10.1080/09205063.2026.2652454

Long Yang, Xiaoyuan Liu, Haotian Bai, Ling Guo, Zonghao Hu, Lihua Yin

{"title":"Mechanically reinforced and bioactive core-shell nanofibrous membranes loaded with astragaloside IV for guided bone regeneration.","authors":"Long Yang, Xiaoyuan Liu, Haotian Bai, Ling Guo, Zonghao Hu, Lihua Yin","doi":"10.1080/09205063.2026.2652454","DOIUrl":"https://doi.org/10.1080/09205063.2026.2652454","url":null,"abstract":"Current barrier membranes for guided bone regeneration (GBR) are often limited by insufficient bioactivity, poor mechanical toughness, and uncontrolled degradation rates. To overcome these challenges, we developed a novel functionalized nanofibrous membrane with a core-shell structure via coaxial electrospinning. The membrane comprises a poly(lactic-co-glycolic acid)/polycaprolactone (PLGA/PCL) shell to ensure structural integrity and a gelatin (Gel) core loaded with astragaloside IV (AS) to enhance water retention capacity and bioactivity. Physically, the incorporation of the Gel core significantly enhanced the mechanical toughness of the scaffold, imparting ductile behavior to the membrane, while maintaining a controlled degradation profile and stable swelling capacity suitable for space maintenance. Biologically, the membrane effectively prevented fibroblast infiltration, fulfilling the critical barrier function. Furthermore, in vitro evaluations with rat bone marrow mesenchymal stem cells (rBMSCs) demonstrated that AS-loaded membrane significantly promoted cell proliferation and osteogenic differentiation. Notably, the 2.5% AS concentration was identified as the optimal formulation, eliciting the most robust upregulation of osteogenic genes (Runx2, Col-1, ALP, OPN, and OCN) and the angiogenic factor vascular endothelial growth factor A (VEGF), as well as maximizing extracellular matrix (ECM) mineralization. Collectively, this study presents a dual-functional GBR membrane that combines enhanced mechanical handling properties and demonstrates bioactivity associated with AS incorporation, offering a promising strategy for repairing critical-sized bone defects.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0