Journal of Biomaterials Science, Polymer Edition最新文献

An update on implication of POSS-based nanocomposites in bone tissue engineering: a review.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-02-18 DOI: 10.1080/09205063.2025.2455234

Leyla Bagheri, Davoud Jafari-Gharabaghlou, Mohammad-Reza Dashti, Nosratollah Zarghami

引用次数: 0

Silk fibroin thermosensitive polymers: Osteogenic, anti-inflammatory, and angiogenic effects for osteomyelitis treatment.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-02-16 DOI: 10.1080/09205063.2025.2458887

Pavarish Jantorn, Chayanee Noosak, Khanin Iamthanaporn, Dennapa Saeloh Sotthibandhu

{"title":"Silk fibroin thermosensitive polymers: Osteogenic, anti-inflammatory, and angiogenic effects for osteomyelitis treatment.","authors":"Pavarish Jantorn, Chayanee Noosak, Khanin Iamthanaporn, Dennapa Saeloh Sotthibandhu","doi":"10.1080/09205063.2025.2458887","DOIUrl":"https://doi.org/10.1080/09205063.2025.2458887","url":null,"abstract":"Infectious bone defects pose a significant challenge in orthopedics by hindering healing and vascularization. This study explored the impact of fibroin thermosensitive hydrogel on osteogenesis, inflammatory response, and angiogenesis as a potential biomaterial for bone regeneration in osteomyelitis treatment. The biocompatibility of the hydrogel by live/dead staining revealed a high number of viable osteoblast cells after 14 days. ALP activity was significantly increased in all hydrogel formulations, with F3 showing the highest levels of total protein content and calcium deposition, indicating more effective osteogenesis. Gene expression analysis of the osteogenesis-related genes demonstrated that RUNX2 was upregulated by day 7, followed by increased expressions of the OCN and COL-1 genes at later stages. The inflammatory response to F3 was assessed by measuring the nitric oxide (NO) production and pro-inflammatory gene expression in LPS-stimulated RAW 264.7 macrophages. The F3 formulation significantly reduced NO production and iNOS expression, suggesting selective inhibition of the inflammatory pathway. The VEGF-loaded F3 formulation exhibited substantial angiogenic potential, enhancing HUVEC cell proliferation by 140% over 48 h. The osteogenic, anti-inflammatory, and angiogenic effects shown by the F3 formulation were well-suited for applications in osteomyelitis treatment.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-17"},"PeriodicalIF":3.6,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multifunctional biomimetic double-layer composite hydrogel with wet adhesion and antioxidant activity for dural repair.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-02-10 DOI: 10.1080/09205063.2025.2460373

Shui Guan, Chang Sun, Chuzhou Wen, Bing Yao, Jianqiang Xu, Changkai Sun

{"title":"A multifunctional biomimetic double-layer composite hydrogel with wet adhesion and antioxidant activity for dural repair.","authors":"Shui Guan, Chang Sun, Chuzhou Wen, Bing Yao, Jianqiang Xu, Changkai Sun","doi":"10.1080/09205063.2025.2460373","DOIUrl":"https://doi.org/10.1080/09205063.2025.2460373","url":null,"abstract":"Cerebrospinal fluid (CSF) leakage caused by accidents or diseases resulting from traumatic brain injury, inflammation, tumor erosion and surgery can lead to many complications. In this study, a multifunctional composite double-layer hydrogel was designed by simulating the structure of native dura mater, which was composed of polyacrylic acid (PAA), polyethyleneimine (PEI), sodium alginate (SA), β-cyclodextrin (β-CD) and edaravone (Ed). The PAA/PEI layer had strong wet adhesion characteristics, while the PEI/SA@β-CD/Ed layer exhibited significant antioxidant, drug release and biocompatibility properties. By controlling the concentration of Ca2+, the gelation time can be adjusted rapidly within 95-215 s. Specifically, the final PAA/PEI/SA@β-CD/Ed composite hydrogel exhibited a porous network structure with high porosity and low swelling rate, improved tensile strength, sufficient biodegradability, favourable adhesion performance, enhanced DPPH and ABTS radicals scavenging abilities, and sustained Ed release capacity. In addition, the resulting hydrogel also showed excellent biocompatibility and protective effect on H2O2-induced oxidative damage in SH-SY5Y cells. These results preliminarily suggested that the PAA/PEI/SA@β-CD/Ed composite hydrogel would appear to be a promising candidate for dural repair.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-22"},"PeriodicalIF":3.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-infrared photothermal silk fibroin/polydopamine nanospheres with incorporated silver nanoparticles for efficient antibacterial application.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-02-10 DOI: 10.1080/09205063.2025.2457265

Liwen Yang, Kai Zou, Shanshan Li, Liu Huang, Kairui Guo, Zihong Feng, Yi Liu, Wei Liu

{"title":"Near-infrared photothermal silk fibroin/polydopamine nanospheres with incorporated silver nanoparticles for efficient antibacterial application.","authors":"Liwen Yang, Kai Zou, Shanshan Li, Liu Huang, Kairui Guo, Zihong Feng, Yi Liu, Wei Liu","doi":"10.1080/09205063.2025.2457265","DOIUrl":"https://doi.org/10.1080/09205063.2025.2457265","url":null,"abstract":"Bacterial infections and the emergence of drug-resistant after the misuse of antibiotics are threats to human health worldwide. Photothermal nanomaterials incorporating metallic antibacterial agents offer a promising solution. Herein, an antibacterial nanocomposite (Ag@SF@PDA) comprising silver nanoparticles (AgNPs) with silk fibroin/polydopamine nanospheres (SF@PDA) was designed for efficient antibacterial application. Specifically, AgNPs were reduced in situ by polydopamine and encapsulated in the polydopamine outer layer. The Ag@SF@PDA, with a diameter of about 144.7 nm, had a spherical shape and a rough surface. Under 808 nm, 1.5 W/cm2 NIR near-infrared (NIR) irradiation, Ag@SF@PDA demonstrated excellent photothermal performance and stability, reaching a maximum temperature of 56.8 °C after 12 min. Their photothermal performance was improved as the concentration increased. The viability results of L929 fibroblasts in vitro demonstrated that Ag@SF@PDA had good biocompatibility. Even when the concentration was increased to 0.5 mg/mL, the cells still maintained their viability. Of note, Ag@SF@PDA exhibited remarkably high antibacterial efficacies against both Staphylococcus aureaus and Escherichia coli after NIR irradiation. Their antibacterial efficacies were above 99.9% under NIR irradiation and comparable to those of ampicillin. These photothermal nanospheres have a great potential in efficient antibacterial application.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Bone Grafts: Unveiling the Degradation Behaviour of Poly (lactic‑co‑glycolic acid) ‑ Calcium Composites for Advanced Bone Repair.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-02-07 DOI: 10.1080/09205063.2025.2460370

Norshazliza Ab Ghani, Sathiya Maran, Mohammed Rafiq Abdul Kadir, Shanmathy Somasundaram, Hanumantha Rao Balaji Raghavendran, Tunku Kamarul Zaman

{"title":"Enhancing Bone Grafts: Unveiling the Degradation Behaviour of Poly (lactic‑co‑glycolic acid) ‑ Calcium Composites for Advanced Bone Repair.","authors":"Norshazliza Ab Ghani, Sathiya Maran, Mohammed Rafiq Abdul Kadir, Shanmathy Somasundaram, Hanumantha Rao Balaji Raghavendran, Tunku Kamarul Zaman","doi":"10.1080/09205063.2025.2460370","DOIUrl":"https://doi.org/10.1080/09205063.2025.2460370","url":null,"abstract":"In orthopaedic clinical applications, creating biocomposite bone substitutes to take the place of autologous bone transplants is still difficult. Studies have demonstrated for decades that poly (lactic-co-glycolic acid) [PLGA], a common polymer, has many benefits that make it a strong contender for bone replacement. These include biodegradability, good mechanical qualities, and the ability to induce new bone production. Although calcium-based materials are frequently used as bone fillers in bone implantation, the efficiency of ceramic materials containing calcium may be hampered by a number of issues, including low microporosity and quick rates of degradation. In order to overcome these obstacles, scientists are investigating ways to improve implant performance by combining PLGA with other materials, especially in terms of encouraging improved connections with nearby bone cells. An overview of the chemical properties of different PLGA-based scaffold composites, as well as the benefits and drawbacks of PLGA-Calcium implants in tissue engineering applications, are the goals of this review. It also highlights the possible advantages and consequences of using PLGA in 3D printing technology to improve bone tissue engineering clinical outcomes.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-27"},"PeriodicalIF":3.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whitlockite nanoparticles incorporated chitin-poly(dioxanone) composite scaffold for alveolar bone regeneration.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-02-07 DOI: 10.1080/09205063.2025.2460377

Kavipriya Murugaiyan, Arthi Chandramouli, Jayakumar Rangasamy

{"title":"Whitlockite nanoparticles incorporated chitin-poly(dioxanone) composite scaffold for alveolar bone regeneration.","authors":"Kavipriya Murugaiyan, Arthi Chandramouli, Jayakumar Rangasamy","doi":"10.1080/09205063.2025.2460377","DOIUrl":"https://doi.org/10.1080/09205063.2025.2460377","url":null,"abstract":"Loss of alveolar bone due to periodontitis is prevalent among a wide range of population and is a major concern for oral health. Treatment of alveolar bone loss is aimed based on the repair of the periodontium as well as type of defect that has been formed. Nanocomposite based hydrogel and scaffolds for alveolar bone regeneration has gained significant attention due to their favourable properties such as stability, biocompatibility and enhanced regeneration. Chitin has been used for decades in biomedical applications owing to its good biological activity, biocompatibility and biodegradability. The addition of synthetic polymer such as polydiaxanone into chitin alters the degradation properties and also enhances the biological properties such as osteogenesis. The addition of bioceramic, whitlockite nanoparticles induces mineralization and osteogenesis. Thus, we developed a composite scaffold (Ch-PDO-nWH) using chitin, polydioxanone and whitlockite nanoparticles, a magnesium based bioceramic. The prepared Ch-PDO-nWH composite scaffold is porous in nature, with swelling property and controlled degradation. The scaffold was tested for its biocompatibility using dental follicle stem cells (DFSCs) which showed improved biocompatibility, biomineralization and also stimulated the expression of osteogenic markers such as RUNX2 and OPN thus ultimately aiding in bone regeneration.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-17"},"PeriodicalIF":3.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in three-dimensional printing of hydrogel formulations for vascularized tissue and organ regeneration.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-02-03 DOI: 10.1080/09205063.2024.2449294

Tien Dat Nguyen, Thanh-Qua Nguyen, Van Toi Vo, Thi-Hiep Nguyen

引用次数: 0

3D printed gastroretentive floating-hollow capsular device (GRF-HCD) for levofloxacin oral delivery using selective laser sintering (SLS) platform technology.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-02-03 DOI: 10.1080/09205063.2025.2458841

Ganesh Pandav, Tukaram Karanwad, Subham Banerjee

{"title":"3D printed gastroretentive floating-hollow capsular device (GRF-HCD) for levofloxacin oral delivery using selective laser sintering (SLS) platform technology.","authors":"Ganesh Pandav, Tukaram Karanwad, Subham Banerjee","doi":"10.1080/09205063.2025.2458841","DOIUrl":"https://doi.org/10.1080/09205063.2025.2458841","url":null,"abstract":"The development of gastroretentive drug delivery systems is one such instance, which was developed to improve the oral bioavailability and effectiveness of drugs, which has a poor absorption window in the upper GIT and/or triggers local activity such as duodenal and stomach activity. In this work, the objective of sintering gastroretentive dosage forms was to sustain the release of levofloxacin in the gastric region for an extended period of time. Selective laser sintering (SLS)-mediated powder bed fusion 3D printing technology was utilized to design and fabricate a modified-release gastroretentive floating-hollow capsular device (GRF-HCD) in three distinct capsule sizes namely, 000, 00, and 0 with the aid of pharmaceutical grade polymers (combinations of Kolliphor P188 and Kollidon SR in 1:1 ratio). Sintered GRF-HCD was further subjected to morphological analysis, weight variation, and swelling index. In addition, in vitro and in vivo buoyancy studies were performed in an animal model using X-ray imaging. Finally, the in vitro drug release from GRF-HCD was performed in simulated gastric pH condition (pH-1.2) upto 12 h. Levofloxacin concentration was then quantified using validated RP-HPLC method. The in vitro floating behaviour was mimicked with the in vivo floating, where the GRF-HCD was retained in the rabbit stomach for an extended period which will help to sustain the drug release for a longer period and maintained the maximum concentration of levofloxacin in the gastric region.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of anticancer drug incorporated aptamer-functionalized cationic β-lactoglobulin: induction of cell cycle arrest and apoptosis in colorectal cancer. 构建掺入抗癌药物的aptamer功能化阳离子β-乳球蛋白：诱导结直肠癌细胞周期停滞和凋亡。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-02-01 Epub Date: 2024-10-16 DOI: 10.1080/09205063.2024.2402142

Zhipeng Zhang, Tianran Zhang, Zimeng Li, Zhijun Zeng

{"title":"Construction of anticancer drug incorporated aptamer-functionalized cationic β-lactoglobulin: induction of cell cycle arrest and apoptosis in colorectal cancer.","authors":"Zhipeng Zhang, Tianran Zhang, Zimeng Li, Zhijun Zeng","doi":"10.1080/09205063.2024.2402142","DOIUrl":"10.1080/09205063.2024.2402142","url":null,"abstract":"Nanoscale drug delivery systems that are both multifunctional and targeted have been developed using proteins as a basis, thanks to their attractive biomacromolecule properties. A novel nanocarrier, aptamer (AS1411)-conjugated β-lactoglobulin/poly-l-lysine (BLG/Ap/PL) nanoparticles, was developed in this study. To this unique formulation, the as-prepared nanocarrier blends the distinctive features of an aptamer as a chemotherapeutic targeting agent with those of protein nanocarriers. By loading cabazitaxel (CTX) onto the nanocarriers, the therapeutic potential of BLG/Ap/PL could be demonstrated. The CTX-loaded BLG/Ap/PL (CTX@BLG/Ap/PL) showed a regulated drug release profile in an acidic milieu, which could improve therapeutic efficacy in cancer cells and have a high drug encapsulation efficacy of up to 93%. However, compared to free CTX, CTX@BLG/Ap/PL killed colorectal HCT116 cancer cells with a higher efficacy at 24 and 48 h. Further investigation confirms the apoptosis by acridine orange and ethidium bromide (AO/EB), and DAPI staining confirms the morphological changes, chromatin condensation, and membrane blebbing in the treated cell through flow cytometry displayed the release of higher percentages of apoptosis. Cell cycle analysis revealed that CTX@BLG/Ap/PL induced sub-G1 and G2/M phase (apoptosis) at 24 and 48 h. Annexin V/propidium iodide (PI) flow cytometry analysis confirmed that CTX@BLG/Ap/PL induces apoptosis in HCT116 cells. Overall, this study proved that CTX@BLG/Ap/PL had several advantages over free chemotherapeutic drugs and showed promise as a solution to the clinical problems associated with targeted antitumor drug delivery systems.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"351-370"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of graphene oxide in an injectable hydrogel on the osteogenic differentiation of mesenchymal stem cells. 可注射水凝胶中的氧化石墨烯对间充质干细胞成骨分化的影响

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-02-01 Epub Date: 2024-09-03 DOI: 10.1080/09205063.2024.2397211

Yaru Zhu, Tao Wang, Zhen He, Mingchong Liu, Chunfang Zhang, Guixin Sun, Qidong Wang

{"title":"Effect of graphene oxide in an injectable hydrogel on the osteogenic differentiation of mesenchymal stem cells.","authors":"Yaru Zhu, Tao Wang, Zhen He, Mingchong Liu, Chunfang Zhang, Guixin Sun, Qidong Wang","doi":"10.1080/09205063.2024.2397211","DOIUrl":"10.1080/09205063.2024.2397211","url":null,"abstract":"Graphene oxide (GO) is widely used in bone tissue engineering due to its good biocompatibility and proliferation, and is often used in combination with other hydrogels, which not only reduces the cytotoxicity of GO but also improves the mechanical properties of the hydrogels. We developed injectable carboxymethyl chitosan (CMC)/hydroxyethyl cellulose (HEC)/β-tricalcium phosphate (β-TCP)/GO hydrogel via hydrogen bonding cross-linked between (CMC) and (HEC), also, calcium cross-linked by β-TCP was also involved to further improvement of mechanical properties of the hydrogel, and incorporate different concentration of GO in these hydrogel systems. The characterization of the novel hydrogel was tested by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). The swelling ratio and mechanical properties were investigated, the results showed that the addition of GO was able to reduce the swelling rate of hydrogels and improve their mechanical properties, with the best effect in the case of 1 mg/mL content. In vivo experimental studies showed that the hydrogel significantly promoted the osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs), with the best effect at a concentration of 2 mg/mL. The results of the cellular experiments were similar. Therefore, the novel environment-friendly and non-toxic injectable CMC/HEC/β-TCP/GO hydrogel system may have potential applications in bone tissue engineering.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"152-168"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0