Journal of Biomaterials Science, Polymer Edition最新文献

Exploring multi-functional biopolymer polyhydroxyalkanoates in diabetes treatment. 探索多功能生物聚合物聚羟基烷酸酯在糖尿病治疗中的应用。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-29 DOI: 10.1080/09205063.2025.2510445

Gunjan Adwani, Sharda Bharti, Awanish Kumar

{"title":"Exploring multi-functional biopolymer polyhydroxyalkanoates in diabetes treatment.","authors":"Gunjan Adwani, Sharda Bharti, Awanish Kumar","doi":"10.1080/09205063.2025.2510445","DOIUrl":"https://doi.org/10.1080/09205063.2025.2510445","url":null,"abstract":"Millions of individuals worldwide suffer from a chronic metabolic disorder, diabetes, defined as a reduction in insulin production or sensitivity, which raises blood glucose levels, weakens the immune system, and results in irregularities in the metabolism of carbohydrates, fats, and proteins. Therefore, there is still a high demand for non-invasive ways to administer insulin and other antidiabetics to treat diabetes and suitable therapeutics for wound healing. This generates a need for novel biomaterials that effectively use diabetes-associated therapy. This article emphasized that some special -features of Polyhydroxyalkanoates (PHAs) are biocompatible, biodegradable thermoplastic polyesters used in biomedical applications, expanding the options for bioresorbable polymers having antidiabetic and antimicrobial activities. PHAs can be synthesized into scaffolds and nanomaterials that release insulin and other antidiabetic medications in a sustained and controlled way that could improve treatment results. Research analysis on the application of PHAs as scaffold materials for bioartificial pancreas development offers a biocompatible and structurally supportive environment to encapsulate pancreatic cells. Further, challenges including excessive production costs, requirement for additional clinical setting optimization, and the current status of PHAs in the market are emphasized in this review. Further research is needed to explore the therapeutic potential of PHAs exhaustively in diabetes therapeutics and management.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printing of methacrylated hyaluronic acid/α-TCP composite scaffold for bone defect repair. 3D打印甲基丙烯酸透明质酸/α-TCP复合骨缺损修复支架。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-28 DOI: 10.1080/09205063.2025.2503930

Minjie Shen, Haoran Liu, Zhijia Shen, Yajie Wang, Xiexing Wu, Chunyang Fan, Yongkang Deng, Jinlong Zhang, Liang Hu, Huilin Yang, Chun Liu

{"title":"3D printing of methacrylated hyaluronic acid/α-TCP composite scaffold for bone defect repair.","authors":"Minjie Shen, Haoran Liu, Zhijia Shen, Yajie Wang, Xiexing Wu, Chunyang Fan, Yongkang Deng, Jinlong Zhang, Liang Hu, Huilin Yang, Chun Liu","doi":"10.1080/09205063.2025.2503930","DOIUrl":"https://doi.org/10.1080/09205063.2025.2503930","url":null,"abstract":"Bone defects can occur due to various reasons, such as trauma, infection, congenital disorders, or surgical interventions like tumor removal. This study presents the development and characterization of a novel 3D printable composite ink integrating α-tricalcium phosphate (α-TCP) with a photocuring polymer hyaluronic acid methacrylyol (HAMA) for bone defect repair. The composite bioink was formulated to address the limitations of traditional bioinks and to harness the benefits of α-TCP's osteoconductivity and the mechanical stability provided by photocuring polymers. The resulting HAMA/α-TCP scaffolds were evaluated for their rheological properties, biocompatibility, mechanical strength, and osteogenic potential both in vitro and in vivo. The study demonstrated that the incorporation of α-TCP into the HAMA matrix significantly enhanced the scaffold's mechanical properties and osteogenic differentiation capacity. In vivo studies using a rat skull defect model confirmed the superior bone regenerative potential of the HAMA/α-TCP scaffolds compared to controls. The findings suggest that the HAMA/α-TCP composite scaffolds offer a promising approach for bone defect repair, highlighting their potential for clinical translation in orthopedic applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-21"},"PeriodicalIF":3.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biocompatible PLA/spirulina microparticles via electrospraying for targeted drug delivery in HUVEC and HaCaT cell lines. 生物相容性聚乳酸/螺旋藻微粒电喷涂在HUVEC和HaCaT细胞中的靶向药物递送。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-27 DOI: 10.1080/09205063.2025.2503928

Basak Dalbayrak, Isil Aksan Kurnaz, Sumeyye Cesur, Oguzhan Gunduz, Elif Damla Arısan

{"title":"Biocompatible PLA/spirulina microparticles via electrospraying for targeted drug delivery in HUVEC and HaCaT cell lines.","authors":"Basak Dalbayrak, Isil Aksan Kurnaz, Sumeyye Cesur, Oguzhan Gunduz, Elif Damla Arısan","doi":"10.1080/09205063.2025.2503928","DOIUrl":"https://doi.org/10.1080/09205063.2025.2503928","url":null,"abstract":"Spirulina platensis, well-known for its abundant nutrients and sustainability, shows potential as a microcarrier for various biotechnological uses. However, its natural degradability presents a challenge. Polylactic Acid (PLA) offers a solution due to its biodegradability and compatibility. By using the electrohydrodynamic atomization technique (electrospraying), precise control over microparticle characteristics like size, shape, and composition is achieved by adjusting parameters such as voltage, flow rate, and solution properties. In this research, microparticles made from Spirulina extract and PLA were created through electrospraying to act as microcarriers. Different formulations were tested, including 3% PLA and blends of Spirulina extract and PLA at concentrations of 0.125%, 0.25%, and 0.5% using chloroform and ethanol in the ratio of 19:1. Through various tests (MTT assay and colony formation test) the biocompatibility of producing microparticles was assessed using HUVEC and HaCaT cell lines, indicating these microparticles' potential for diverse applications as microcarrier systems.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development, optimization, and characterization of microbially triggered Mimosa pudica gum-chitosan polyelectrolyte complex for colon-targeted drug delivery. 微生物触发的含羞草胶-壳聚糖多电解质复合物结肠靶向给药的开发、优化和表征。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-26 DOI: 10.1080/09205063.2025.2504711

Samridhi Kurl, Gurpreet Kaur

{"title":"Development, optimization, and characterization of microbially triggered Mimosa pudica gum-chitosan polyelectrolyte complex for colon-targeted drug delivery.","authors":"Samridhi Kurl, Gurpreet Kaur","doi":"10.1080/09205063.2025.2504711","DOIUrl":"https://doi.org/10.1080/09205063.2025.2504711","url":null,"abstract":"This study aimed to develop a novel polymeric complex composed of Mimosa pudica gum (MMG) and chitosan (CH) and to explore its potential as a delivery system for targeting drugs to the colon. The method of extraction of MMG was optimized, resulting in a maximum yield of 12.41%. The molecular weight of the gum was determined to be 5.07 × 106 Da, and it was characterized for its physicochemical and rheological properties. A species distribution profile was constructed using the pKa values of both polymers, and polyelectrolyte complexes (PECs) were prepared at a pH value of 5.25 ± 0.10. The 40:60 (MMG: CH) PECs exhibited the highest yield (99%), minimal viscosity, and near-neutral zeta potential. Microflora biodegradation studies of PECs in pH 6.8 buffer containing rat cecal contents showed a pH decrease, likely due to degradation products of the PECs. In vitro drug release studies revealed 16.6% capecitabine release (model drug) from PECs without rat cecal contents, compared to 88.5% release after 24h with rat cecal contents. These findings suggest that MMG-CH PECs could serve as promising vehicles for microbially triggered, colon-targeted drug delivery systems.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral natural material hydrogels: a new strategy for enhancing oral drug delivery efficiency. 口服天然材料水凝胶：提高口服给药效率的新策略。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-26 DOI: 10.1080/09205063.2025.2509028

Qi Yang, Xi Xiang, Han Wang, Yue Liao, Xinzhi Li

{"title":"Oral natural material hydrogels: a new strategy for enhancing oral drug delivery efficiency.","authors":"Qi Yang, Xi Xiang, Han Wang, Yue Liao, Xinzhi Li","doi":"10.1080/09205063.2025.2509028","DOIUrl":"https://doi.org/10.1080/09205063.2025.2509028","url":null,"abstract":"Oral administration, owing to its high patient compliance and favorable controllability, is widely employed in clinical settings; however, the efficacy is often constrained by the gastrointestinal environment's impact on bioavailability. As the demand for biocompatibility and biodegradability in biomedical applications intensifies, natural hydrogel-based oral drug delivery systems have gained substantial attention as promising carriers. In this study, we introduce a variety of natural materials, revealing their advantages in enhancing drug bioavailability and targeting capabilities. Through both physical and chemical crosslinking mechanisms, we successfully demonstrate hydrogels exhibiting excellent mechanical properties and biocompatibility. Furthermore, we analyze the potential applications of diverse natural oral hydrogels across fields such as gastrointestinal, metabolic, oncological, and immunotherapeutic diseases. By synthesizing recent advances in this area, we aim to elucidate the critical role these systems can play in biomedicine. Our findings suggest that natural materials possess broad prospects in drug delivery, advocating for continued exploration of their clinical application to facilitate the development and optimization of novel oral therapeutic modalities. This work provides a vital theoretical foundation and practical guidance for future innovations in drug delivery technologies.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-28"},"PeriodicalIF":3.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of carob honey loaded chitosan nanoparticles and determination of its antimicrobial potential and cytotoxic effect on breast cancer cell line. 角豆蜜负载壳聚糖纳米颗粒的合成及其抑菌潜能和对乳腺癌细胞毒作用的测定。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-24 DOI: 10.1080/09205063.2025.2505702

Bashir Ahmad, Erkay Özgör, Doga Kavaz, Ahmad Shehu

{"title":"Synthesis of carob honey loaded chitosan nanoparticles and determination of its antimicrobial potential and cytotoxic effect on breast cancer cell line.","authors":"Bashir Ahmad, Erkay Özgör, Doga Kavaz, Ahmad Shehu","doi":"10.1080/09205063.2025.2505702","DOIUrl":"https://doi.org/10.1080/09205063.2025.2505702","url":null,"abstract":"Embedding natural products into chitosan nanoparticles (CNP) is an effective way to produce a novel combination with better antimicrobial and anticancer activities. Therefore, this study aims to incorporate carob honey (CH) into CNP, determine its potential antimicrobial along with antiproliferative activities, by well diffusion and MTT cell viability assays, respectively. Successful loading of CH in CNP was confirmed after due characterization. The nanoparticles, synthesized by ionic gelation method, produced a small (101.3 ± 4.13 nm), stable (+27.27 ± 0.95 mV), and monodispersed (0.2265 ± 0.0027) CH-loaded CNP (CHCNP). The best antibacterial activity occurred in Klebsiella pneumoniae (K. pneumoniae) (23 ± 0 mm to 16 ± 1.7 mm) followed by Escherichia coli (E. coli) (18 ± 2.0 mm to 10 ± 1 mm). Meanwhile, Aspergillus niger (A. niger) and Aspergillus flavus (A. flavus) were evenly inhibited with inhibition zones in the range of 15 ± 3 mm to 7 ± 0.8 mm and 15 ± 5 mm to 9 ± 1.4 mm, respectively. CHCNP showed a remarkable cytotoxic effect on MDA-MB-231 according to concentration and time, with IC50 of 25 ± 5 to 18 ± 2.6 μg/mL within 24-72 h. These findings demonstrated the feasibility of loading CH in CNP to form a nanoformulation that could potentially serve as a target-specific therapeutic agent in the treatments of microbial infections and breast cancer. However, there is a need for further research on the safety, dosage optimization, in vivo studies and mechanisms of action of the nanoparticles.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-21"},"PeriodicalIF":3.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of recent advancements in 4D printing of alginate hydrogels for tissue regeneration. 海藻酸盐水凝胶用于组织再生的4D打印的最新进展概述。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-24 DOI: 10.1080/09205063.2025.2509031

Yehang Liu, Aixiang Ding

{"title":"An overview of recent advancements in 4D printing of alginate hydrogels for tissue regeneration.","authors":"Yehang Liu, Aixiang Ding","doi":"10.1080/09205063.2025.2509031","DOIUrl":"https://doi.org/10.1080/09205063.2025.2509031","url":null,"abstract":"4D printing of alginate hydrogels has emerged as a transformative strategy in tissue engineering, enabling the fabrication of stimuli-responsive scaffolds that recapitulate the temporal and spatial complexities of native tissues. Leveraging alginate's tunable crosslinking, biocompatibility, and easy modification, recent research has demonstrated the successful design of constructs capable of programmable shape morphing in response to physiological stimuli. This review highlights recent advances in polymer design, including methacrylated, oxidized, and ligand-functionalized alginate derivatives, and cutting-edge 4D printing technologies such as extrusion-based and photopolymerization-based printing technologies. Notably, these systems have shown promising outcomes in regenerating cartilage, bone, vascular, and neural tissues. However, key challenges remain, including the standardization of shape-morphing quantification, enhancement of mechanical robustness, improvement of host tissue integration, and the replication of native tissue complexity. This review concludes with a critical evaluation of current limitations and future directions, highlighting the potential of integrating 4D alginate hydrogel systems with emerging technologies such as artificial intelligence, machine learning, organoid models, and bioelectronic interfaces to accelerate innovation and broaden their application in tissue engineering. By synthesizing recent advancements and offering insights into the implementation of 4D alginate hydrogels, this review aims to stimulate continued progress in this rapidly evolving field.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-34"},"PeriodicalIF":3.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous biocompatible composite scaffold (CS/MFC/HAp) with N-Boc L-cysteine methyl ester for bone tissue engineering applications. 含N-Boc l -半胱氨酸甲酯的多孔生物相容性复合支架（CS/MFC/HAp）用于骨组织工程。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-24 DOI: 10.1080/09205063.2025.2509425

Sivasankar Mv, Sreenivasa Rao Parcha

{"title":"Porous biocompatible composite scaffold (CS/MFC/HAp) with N-Boc L-cysteine methyl ester for bone tissue engineering applications.","authors":"Sivasankar Mv, Sreenivasa Rao Parcha","doi":"10.1080/09205063.2025.2509425","DOIUrl":"https://doi.org/10.1080/09205063.2025.2509425","url":null,"abstract":"In this study, we fabricated composite scaffolds containing micro-fibrillated cellulose (MFC), chitosan (CS), and hydroxyapatite (HAp) were fabricated using the freeze-drying technique. N-Boc-L-cysteine methyl ester (NBLCME) was synthesized and incorporated into the composite scaffold (CS/MFC/HAp) at different concentrations (20-100µg/ml). The composite scaffolds were characterized by SEM and FTIR results. Interconnected porous structure showed that the scaffolds had 80-90% porosity with a pore diameter range of 100-450µm and fiber lengths of 6.1 -11.87 µm. FTIR analysis confirmed the interaction between CS/MFC/HAp and NBLCME. The treated scaffolds exhibited sustained drug delivery following Fickian diffusion behavior (n ≤ 0.45). The biological study of treated scaffolds on human osteosarcoma cells (MG63 cell line) was evaluated by examining cell viability, ALP, ARS activities, and cell adhesion. The cytotoxicity of the treated scaffolds showed no cytotoxic effects on the MG63 cell line. ALP and ARS activities showed significantly enhanced phosphate and calcium deposition on the scaffold. Taken together, the result suggested that the fabricated composite scaffold (CS/MFC/HAp) incorporated with NBLCME showed excellent properties and its potential for bone-related applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-17"},"PeriodicalIF":3.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent developments in 3D printing pharmaceutical, bioprinting and implant for tissue engineering formulations. 最近在3D打印制药，生物打印和植入组织工程配方的发展。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-22 DOI: 10.1080/09205063.2025.2505350

Ranjitsinh Pawar, Ankeeta Sankapall, Mayur Samal, Vaishnavi Sadaphal, Sabeeha Mohiudin, Mangesh Sangale

{"title":"Recent developments in 3D printing pharmaceutical, bioprinting and implant for tissue engineering formulations.","authors":"Ranjitsinh Pawar, Ankeeta Sankapall, Mayur Samal, Vaishnavi Sadaphal, Sabeeha Mohiudin, Mangesh Sangale","doi":"10.1080/09205063.2025.2505350","DOIUrl":"https://doi.org/10.1080/09205063.2025.2505350","url":null,"abstract":"This review article explores how 3D printing has the diversity in the drug development and the delivery of personalized medicine. The paradigm shift is from conventional methods to tailormade dosages and exploring the intricate interplay of drug selection, polymer compatibility alongwith technological advancements within the pharmaceutical arena. 3D printing is positioned as a crucial tool for catering to the specific requirements of patient-focused fields like pediatrics and geriatrics, ranging from addressing individual needs to improving dosage precision. By harnessing genetic profiles, physiological nuances, and disease conditions, this technology enables the creation of bespoke medications with unique drug loading and release profiles. In developing the newer implants the 3D printing has to be developed alongwith consideration of biological aspects as well as technical aspects. It has to be aligned with multifunctional aspects to cater one optimized product. Furthermore, this paper elucidates the regulatory considerations and industrial implications surrounding 3D printing in pharmaceuticals. Emphasizing compliance with current Good Manufacturing Practices (CGMP) and its potential for streamlined production in regulated markets, the paper underscores the transformative power of 3D printing in reshaping clinical practice and optimizing patient outcomes.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-48"},"PeriodicalIF":3.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclodextrin-grafted thermo/redox dual-responsive polymer mediated by disulfide bridges for regulated drug delivery. 二硫桥介导环糊精接枝热/氧化还原双响应聚合物调控药物传递。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-21 DOI: 10.1080/09205063.2025.2506207

Zhijia Yan, Xin Xu, Jinku Xu

{"title":"Cyclodextrin-grafted thermo/redox dual-responsive polymer mediated by disulfide bridges for regulated drug delivery.","authors":"Zhijia Yan, Xin Xu, Jinku Xu","doi":"10.1080/09205063.2025.2506207","DOIUrl":"https://doi.org/10.1080/09205063.2025.2506207","url":null,"abstract":"Tumor cells usually highly expressed reducing glutathione that can break out disulfide bond. In this article, a novel cyclodextrin-containing thermo/redox dual-responsive polymer, PNIPAM-SS-β-CD, was synthesized by copolymerization between monomers of N-isopropylacrylamide (NIPAM) and mono-methacrylated β-cyclodextrin mediated by disulfide bond (MA-SS-β-CD). The dual- responsive polymer has a weight-average molecular weight (Mw) of 53.75 kDa with 45.5 wt% β-CD content, and the polymerization degree ratio of the two structural units form NIPAM and MA-SS-β-CD in the polymer is about 9.26. The polymer can dissolve in water to form hydrogel with a regulating phase transition temperature from 33 to 36 °C. Cytotoxicity assays and hemolysis tests respectively demonstrated over 95% cell viability and no significant hemolytic activity, indicating its superior biocompatibility. Curcumin was used as a model to evaluate drug loading and in vitro release behavior of the thermo/redox dual-responsive polymer. It was revealed that the copolymer (PNIPAM-SS-β-CD) shows a 5.5 folds higher loaded amount and a slower drug release over 24 h than that of poly(N-isopropylacrylamide) (PNIPAM). Notably, the polymer exhibited rapid drug release through disulfide bond cleavage in response to reduced glutathione (GSH, 3 mM), highlighting its potential for targeted cancer therapy.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-19"},"PeriodicalIF":3.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0