Journal of Biomaterials Science, Polymer Edition最新文献

Puerarin and dextran complex alleviates heat stress-induced hippocampal apoptosis and oxidative damage: therapeutic potential for hypothalamic neuronal damage in mice. 葛根素和葡聚糖复合物减轻热应激诱导的海马细胞凋亡和氧化损伤：对小鼠下丘脑神经元损伤的治疗潜力。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-24 DOI: 10.1080/09205063.2025.2506925

Biyue Zhang, Weiwei Li, Yutang Wu, Chunzhan Hong, Shitu Zhuo, Miao Yu, Zeming Guo, Huasong Lin, Lichao Ye, Zhenwu Zhao

{"title":"Puerarin and dextran complex alleviates heat stress-induced hippocampal apoptosis and oxidative damage: therapeutic potential for hypothalamic neuronal damage in mice.","authors":"Biyue Zhang, Weiwei Li, Yutang Wu, Chunzhan Hong, Shitu Zhuo, Miao Yu, Zeming Guo, Huasong Lin, Lichao Ye, Zhenwu Zhao","doi":"10.1080/09205063.2025.2506925","DOIUrl":"https://doi.org/10.1080/09205063.2025.2506925","url":null,"abstract":"Puerarin (Pn), a naturally occurring flavonoid, possesses numerous therapeutic qualities, while Dextran (Dn) is a naturally derived polysaccharide. Here, we examined the puerarin-dextran complex (Pn/Dn), characterization to confirming its functional groups through morphological and structural properties. Cytocompatibility assessments on HT22 cell lines along with ROS and MDA content analysis revealed higher cytocompatibility with Pn/Dn complex treatment, when compared to heat-stressed and control groups. Additionally, elevated oxidative stress levels were found to reduce after treatment with Pn/Dn complex. Flow cytometry analysis demonstrated that HT22 cells treated with puerarin, dextran, and the Pn/Dn complex exhibited preserved viability, with a reduced percentage of cells undergoing early and late apoptosis, particularly at concentrations below 20%, indicating effective prevention of cell death. Importantly, In vivo results proposed that neuronal death in various histopathological observations involves both neurons and surrounding glial cells. These findings demonstrate that the Pn/Dn complex effectively influenced in reduced hippocampal neuronal injury in mice, as confirmed by histological examination. Overall, this study highlights the protective effects of Pn/Dn complex against heat-induced neuronal injury and oxidative stress, emphasizing their potential therapeutic applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-19"},"PeriodicalIF":3.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissolvable microneedles based on active components of Chinese Herbal Medicine for enhanced treatment of skin diseases. 基于中草药活性成分的可溶解微针，用于增强治疗皮肤病。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-22 DOI: 10.1080/09205063.2025.2535492

Kai Ye, Ziyan Chen, Lan He, Huayi Wu, Zeyu Chen, Jing Tan

{"title":"Dissolvable microneedles based on active components of Chinese Herbal Medicine for enhanced treatment of skin diseases.","authors":"Kai Ye, Ziyan Chen, Lan He, Huayi Wu, Zeyu Chen, Jing Tan","doi":"10.1080/09205063.2025.2535492","DOIUrl":"https://doi.org/10.1080/09205063.2025.2535492","url":null,"abstract":"According to World Health Organization (WHO) estimates, around 900 million people globally are affected by various skin diseases, which cause significant physical and psychological distress and place a heavy economic burden on healthcare systems. The primary challenges in treating skin diseases include the limited transdermal drug absorption due to the skin barrier, the side effects associated with medications, and the recurring nature of these conditions that lead to prolonged patient suffering. Microneedles (MNs) have emerged as a promising transdermal drug delivery technology, able to painlessly penetrate the stratum corneum and deliver medications directly to the affected area. Various types of MNs technology have been developed, including dissolvable MNs (DMNs), solid MNs, coated MNs, hollow MNs, and hydrogel-based MNs. DMNs, especially, offer non-invasive drug delivery with sustained release through their dissolvable nature. Combining active ingredients from Chinese Herbal Medicine (CHM), known for their natural anti-inflammatory and antibacterial properties with minimal side effects, with DMNs provides an effective approach for treating skin diseases. This review aims to provide a comprehensive overview of the application of CHM-based DMNs in treating psoriasis, acne, hypertrophic scars, keloids, melanoma, atopic dermatitis, and other skin conditions. Additionally, it will introduce the manufacturing methods for CHM-based DMNs, explore strategies for integrating CHM with MNs, and summarize the broad translational potential and challenges of this technology in the field of dermatology.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-25"},"PeriodicalIF":3.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-generation nanomedicine: the impact of graphene oxide and quantum dots on drug delivery. 下一代纳米医学：氧化石墨烯和量子点对药物传递的影响。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-22 DOI: 10.1080/09205063.2025.2533475

Hamza AbuOwida, Suleiman Ibrahim Mohammad, Asokan Vasudevan

{"title":"Next-generation nanomedicine: the impact of graphene oxide and quantum dots on drug delivery.","authors":"Hamza AbuOwida, Suleiman Ibrahim Mohammad, Asokan Vasudevan","doi":"10.1080/09205063.2025.2533475","DOIUrl":"https://doi.org/10.1080/09205063.2025.2533475","url":null,"abstract":"Graphene oxide (GO) and graphene quantum dots (GQDs) are two well-known graphene-related materials derived from a single layer of C-atoms which are arranged in a honeycomb structure. Due to their unique physicochemical properties such as high specific surface area, excellent electrical conductivity, good mechanical strength, and intrinsic biocompatibility, GO and GQDs have drawn great attention in versatile scientific domains, especially in biomedical applications. Recently, they have been recognised as potential sources for new therapeutic approaches, particularly in influencing inflammatory responses and cancer therapy. The drug and imaging agent loading and delivery ability, ease of transport and release, targeting ability, and imaging canny have met them to be attractive carriers for next generation nanomedicine. Particularly their involvement in selective drug delivery systems represents an opportunity to improve so to speak the therapeutic efficacy, by confining the exposure to the therapeutic such to reach the desired tissue/tumor further abating the treatment of the healthy cells. In this review, we discuss the recent advances in the development and application of GO- or GQD-based delivery systems and put emphasis on strategies utilized to improve the targeting capability, biocompatibility, and therapeutic efficacy for cancer treatment.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-19"},"PeriodicalIF":3.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A microphysiological systems approach to design gastrointestinal system. 用微生理系统方法设计胃肠系统。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-21 DOI: 10.1080/09205063.2025.2532567

Vidhi Mathur, Mrunmayi Gadre, Amrutha H K, Kirthanashri S Vasanthan

{"title":"A microphysiological systems approach to design gastrointestinal system.","authors":"Vidhi Mathur, Mrunmayi Gadre, Amrutha H K, Kirthanashri S Vasanthan","doi":"10.1080/09205063.2025.2532567","DOIUrl":"https://doi.org/10.1080/09205063.2025.2532567","url":null,"abstract":"The gastrointestinal (GI) system is a complex and dynamic organ system, with the anatomy and varied physiological functionality adding complexity to nutrient absorption, immune function, and maintenance of overall health. This review begins with an overview of the anatomy, highlighting key organs and their respective roles, followed by an exploration of the functionality and physiology, detailing mechanisms of digestion, and microbial interactions. Traditional in vitro models and animal studies often fall short in accurately replicating the intricate environment of the human gut. Microphysiological systems (MPS) offer innovative solutions, integrating advanced techniques such as 3D bioprinting, spheroids, organoids, and microfluidics to create more accurate and dynamic models and have emerged as promising solutions to bridge this gap. This paper delves into the applications of MPS in the context of the GI system, including 3D bioprinted models that provide structural fidelity, intestinal organoids that mimic cellular complexity, and gut-on-chip devices that recreate the physiological environment. The transformative potential of MPS in overcoming the limitations of conventional models and accelerating biomedical research and therapeutic development in the GI domain is being well studied. These cutting-edge technologies hold promise for enhancing our understanding of GI biology, improving drug testing, and advancing personalized medicine.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-42"},"PeriodicalIF":3.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of RGD-fused silk fibroin in a solution format on the proliferation and gene expression of epidermal keratinocytes. rgd融合丝素蛋白对表皮角质形成细胞增殖和基因表达的影响。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-20 DOI: 10.1080/09205063.2025.2535493

Yusuke Kambe, Michinobu Hirata, Hirohito Nishi, Tsunenori Kameda

{"title":"Effects of RGD-fused silk fibroin in a solution format on the proliferation and gene expression of epidermal keratinocytes.","authors":"Yusuke Kambe, Michinobu Hirata, Hirohito Nishi, Tsunenori Kameda","doi":"10.1080/09205063.2025.2535493","DOIUrl":"https://doi.org/10.1080/09205063.2025.2535493","url":null,"abstract":"In cutaneous wound healing, it is important to stimulate the functions of skin cells such as keratinocytes and fibroblasts. In this study, we investigated the effects of transgenic silk fibroin (SF) fused with the cell-adhesive Arg-Gly-Asp (RGD) peptide (RGD-SF) on behavior of normal human epidermal keratinocytes. RGD-SFs were added to the culture medium to stimulate keratinocyte proliferation. In addition, immunostaining and DNA microarrays revealed that keratinocytes treated with RGD-SF showed distributed dash-like vinculin (a focal adhesion protein) and increased expression of genes related to cell migration in cutaneous wound healing, such as serine protease inhibitor clade E member 1 and matrix metalloproteinase 9. Although RGD-SF in solution was unable to permeate the stratum corneum of a normal human three-dimensional epidermal model, the transgenic SF reached keratinocytes in the epidermal layer when administered to an epidermal model with immature stratum corneum. The results of this study suggest the potential of RGD-SF in a solution format as an active component in the treatment of skin with a damaged stratum corneum, such as chapped skin.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-13"},"PeriodicalIF":3.6,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-modified gelatin hydrogel scaffolds with imprinted microgrooves: physical characterization and study on endothelial cell interaction. 带有印迹微沟槽的表面改性明胶水凝胶支架：物理表征及内皮细胞相互作用的研究。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-20 DOI: 10.1080/09205063.2025.2527912

Ali Salehi, Lena Rutz, Konstantin Ulbrich, Johanna Stevens, Markus Guttmann, Matthias Worgull, Giorgio Cattaneo

{"title":"Surface-modified gelatin hydrogel scaffolds with imprinted microgrooves: physical characterization and study on endothelial cell interaction.","authors":"Ali Salehi, Lena Rutz, Konstantin Ulbrich, Johanna Stevens, Markus Guttmann, Matthias Worgull, Giorgio Cattaneo","doi":"10.1080/09205063.2025.2527912","DOIUrl":"https://doi.org/10.1080/09205063.2025.2527912","url":null,"abstract":"Endothelialization of biomaterials enhances biocompatibility, hemocompatibility, and reduces inflammatory responses in blood-contacting materials. Surface topographies, particularly groove-like structures, influence endothelial cell morphology and function. This study investigates the impact of microgroove dimensions on endothelialization in gelatin hydrogel scaffolds, alongside assessing their physical and mechanical properties. Using sequential replications, six microgroove geometries with widths ranging from 2.86 µm to 84.20 µm and depths from 284 nm to 919 nm were fabricated on gelatin hydrogel. Surface characterization of the scaffolds over 5 days using confocal microscopy revealed a shrinkage followed by dimensional stability after 24 h. Tensile testing after conditioning in cell culture environments showed Young's modulus of 327.2-529.5 kPa comparable to natural blood vessels. Cultivation of human endothelial cells demonstrated improved cell orientation and elongation on microstructured surfaces. Notably, two specific microgrooved scaffolds (9.33 µm width, 599 nm depth and 22.27 µm width, 919 nm depth) enhanced cell proliferation, adhesion and accelerated confluent monolayer formation as confirmed through fluorescent staining for cell nuclei, Vinculin, and VE-cadherin expression, respectively. This study identifies optimal microgroove dimensions for surface modification of gelatin hydrogel scaffolds demonstrating how geometric cues can positively impact cell morphology and function. This surface engineering approach has a potential application in in vitro endothelialized models for cardiovascular research as well as in vascular implants for tissue remodeling.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-36"},"PeriodicalIF":3.6,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress of hydrogels as sports medical materials: characteristics, modification strategies and application prospects in sports. 水凝胶运动医用材料研究进展：特点、改性策略及在运动中的应用前景

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-20 DOI: 10.1080/09205063.2025.2534688

Ping Shen, Jie Wu, Hao Han, Yunting Bai, Xixi Zhang, Ruipeng Shao

{"title":"Recent progress of hydrogels as sports medical materials: characteristics, modification strategies and application prospects in sports.","authors":"Ping Shen, Jie Wu, Hao Han, Yunting Bai, Xixi Zhang, Ruipeng Shao","doi":"10.1080/09205063.2025.2534688","DOIUrl":"https://doi.org/10.1080/09205063.2025.2534688","url":null,"abstract":"Hydrogels, innovative biomaterials defined by their three-dimensional porous structure, have attracted considerable attention in sports medicine for their unique physical and chemical properties. These properties enable applications in sports injury repair, sports health management, and sports injury protective equipment. By carefully selecting compositions, optimizing structures, and incorporating functional molecules or groups, these hydrogels can achieve enhanced biocompatibility, adhesion, tunable mechanical properties, and intelligent responsiveness, thereby better supporting sports medicine applications. Advances in hydrogel functionalization and performance modulation technologies have demonstrated their potential in applications such as intelligent ligaments, sports insoles, sports wound healing, artificial tendons, bone repair, coatings for sports medical devices, and motion monitoring. This review examines hydrogels with sports medical characteristics and their associated modification strategies. Additionally, this review discusses the current landscape and challenges of hydrogel applications in sports medicine, offering insights and direction for future research in this field.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-29"},"PeriodicalIF":3.6,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in nanotechnology for PARP inhibitor delivery: a comprehensive review of diverse nanosystems, their mechanisms, and therapeutic applications across cancer and beyond. 纳米技术在PARP抑制剂递送中的进展：各种纳米系统、它们的机制以及在癌症和其他领域的治疗应用的综合综述。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-18 DOI: 10.1080/09205063.2025.2534698

Bassam M Abualsoud, Majid Alhomrani, Abdulhakeem S Alamri, Walaa F Alsanie, Suhas Ballal, Girish Chandra Sharma, T Krithiga, Abhayveer Singh, Arun Kumar, Deepak A

{"title":"Advancements in nanotechnology for PARP inhibitor delivery: a comprehensive review of diverse nanosystems, their mechanisms, and therapeutic applications across cancer and beyond.","authors":"Bassam M Abualsoud, Majid Alhomrani, Abdulhakeem S Alamri, Walaa F Alsanie, Suhas Ballal, Girish Chandra Sharma, T Krithiga, Abhayveer Singh, Arun Kumar, Deepak A","doi":"10.1080/09205063.2025.2534698","DOIUrl":"https://doi.org/10.1080/09205063.2025.2534698","url":null,"abstract":"Poly (ADP-ribose) polymerase (PARP) inhibitors have appeared as a transformative class of anticancer agents, particularly for tumors with homologous recombination deficiencies such as BRCA1/2-mutated breast, ovarian, prostate, and pancreatic cancers. Despite their clinical success, challenges such as poor bioavailability, systemic toxicity, and acquired resistance have limited their broader application. Nanotechnology-based drug delivery systems offer a promising strategy to overcome these limitations by enhancing the solubility, stability, and tumor-specific accumulation of PARP inhibitors while reducing off-target effects. This review explores the mechanism of action of PARP inhibitors, including their role in DNA repair and synthetic lethality, and discusses their therapeutic applications. Furthermore, recent progresses in delivery systems, including lipid-based, polymeric, inorganic, and hybrid nanosystems, are examined with a focus on their design, functionality, and impact on drug efficacy. Recent studies demonstrating improved drug retention, enhanced tumor targeting, and controlled release mechanisms are highl'hted, along with potential strategies to overcome resistance. The integration of multifunctional and stimuli-responsive nanosystems further enhances the therapeutic potential of PARP inhibitors. Continued innovation in nanomedicine holds the potential to optimize PARP inhibitor therapy and expand its clinical utility in personalized cancer treatment. Future directions include addressing translational challenges, scalability, and regulatory considerations for clinical applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-62"},"PeriodicalIF":3.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new developed nano-curcumin containing dental hemostatic material; in vitro and the clinical assessments. 新型纳米姜黄素口腔止血材料的研制体外及临床评价。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-16 DOI: 10.1080/09205063.2025.2528493

Leila Chodari, Sina Taghilou, Shadi Mohammadpour Asl, Mohammad Ali Ghavimi, Hamid Taghilou, Solmaz Maleki Dizaj, Simin Sharifi

{"title":"A new developed nano-curcumin containing dental hemostatic material; in vitro and the clinical assessments.","authors":"Leila Chodari, Sina Taghilou, Shadi Mohammadpour Asl, Mohammad Ali Ghavimi, Hamid Taghilou, Solmaz Maleki Dizaj, Simin Sharifi","doi":"10.1080/09205063.2025.2528493","DOIUrl":"https://doi.org/10.1080/09205063.2025.2528493","url":null,"abstract":"Curcumin has antioxidant, anti-inflammatory, and cardiovascular protective effects. This study aimed to develop and evaluate an innovative biodegradable hemostatic gelatinous sponge containing curcumin nanoparticles for use in dentistry. This research investigated the efficacy and safety of this material in both in vitro tests and some clinical settings. The novel sponge was prepared via the freeze-drying method. It was characterized by common approaches. The biocompatibility and biological effects of the new sponge were evaluated in vitro. In the next step, thirty-eight patients who needed dental extraction on two teeth were selected for clinical assessment. The prepared sponge was placed inside the cavity of the experimental group. On the control side, the teeth were extracted normally. All patients were studied for pain, swelling, repair of the extracted site, clot quantity, and the occurrence of dry sockets. Results revealed a porous structure with micro- and nanosized pores and a 12-day degradation period. The produced sponge could absorb blood 38 times its weight. It showed no toxic effect. In the clinical study, pain reduction was larger in the experimental group compared to the control group. The extracted site was normal in terms of repair and clot formation. Finally, there was no dry socket in any of the experimental and control groups. The abovementioned advantages may make the new sponge more effective in tooth extraction and other surgical applications in dentistry.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-14"},"PeriodicalIF":3.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic evaluation of anti-diabetic and hypolipidemic effects of Alangium salvifolium and Ocimum sanctum extracts. 丹参提取物和麝香提取物降糖降血脂的协同作用评价。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-14 DOI: 10.1080/09205063.2025.2527254

Deepak Jain, Pankaj Sharma, Vinay Jain

{"title":"Synergistic evaluation of anti-diabetic and hypolipidemic effects of Alangium salvifolium and Ocimum sanctum extracts.","authors":"Deepak Jain, Pankaj Sharma, Vinay Jain","doi":"10.1080/09205063.2025.2527254","DOIUrl":"https://doi.org/10.1080/09205063.2025.2527254","url":null,"abstract":"In this study, Alangium salvifolium and Ocimum sanctum extracts were investigated for their antioxidant, antidiabetic and hypolipidemic activities individually and in combined form. HPLC, LC-MS and UPLC phytochemicals profiling identified phenolics and flavonoids as major bioactives. Antioxidant assays showed significant DPPH and ABTS radical scavenging activities, with the combined formulation (1:1 ratio) 91.2 and 89.6% inhibition was achieved respectively. Antidiabetic activities were first investigated in vitro with the ability of the combination to inhibit both α-amylase (IC50 = 38.4 µg/mL) and α-glucosidase (IC50 = 45.2 µg/mL) having the strongest inhibitory effects. The hypolipidemic activity included inhibition of lipid peroxidation (78.5%); pancreatic lipase inhibition (70.2%). The bioactives were further molecular docked to find strong binding affinities with PPARγ, DPP-IV, and HMG-CoA reductase. Results were confirmed statistically different (p < 0.05) between treated and control groups. These results suggest that the extracts can exhibit synergy as natural therapeutics in diabetes and lipid disorders.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-29"},"PeriodicalIF":3.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0