Journal of Biomaterials Science, Polymer Edition最新文献

{"title":"DNA-driven enhancement of ocular drug delivery: formulation and evaluation of diclofenac-loaded HPMC films.","authors":"Pratikeswar Panda, Rajaram Mohapatra","doi":"10.1080/09205063.2025.2570367","DOIUrl":"https://doi.org/10.1080/09205063.2025.2570367","url":null,"abstract":"<p><p>The use of DNA in ocular drug delivery as a polymeric bio additive has potential in modulating the physicochemical properties of the film former to sustain drug release. This study reports the development and evaluation of DNA-incorporated HPMC film matrices to improve the ocular delivery and therapeutic efficacy of Diclofenac. Four formulations (DH1-DH4) were prepared with increasing DNA ratios (0, 1:0.01, 1:0.02, and 1:0.03). FTIR, DSC, and XRD analyses confirmed amorphous dispersion of Diclofenac within the matrix without chemical degradation, while SEM revealed a uniform and smooth film morphology. DNA incorporation significantly enhanced hydration (DH4: 620 ± 31.45%), transparency (DH4: ∼55% transmittance at 800 nm), and matrix erosion (DH4: 432 ± 30.25%), which contributed to improved drug release (DH4: 88.3 ± 2.6% at 300 min) and permeation (DH4: 89.5 ± 3.2% at 12 h). Kinetic modeling indicated a strong fit to the Higuchi model (R² = 0.95-0.99), while Korsmeyer-Peppas n values (0.37-0.52) suggested anomalous (non-Fickian) diffusion mechanisms. Stability studies confirmed high moisture retention (DH4: 96 ± 1.5%) and tensile strength (DH4: 20 ± 1.5 MPa) over three months, ensuring the formulation's shelf stability. Antioxidant assays demonstrated superior activity in DH4, with DPPH (IC₅₀: 32 ± 1.8 μM) and H₂O₂ scavenging (IC₅₀: 39 ± 1.7 μM). Overall, Diclofenac-DNA-HPMC films, particularly DH4, exhibit significant potential for effective ocular drug delivery by enhancing the therapeutic performance while maintaining stability and patient compliance.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucilage-based nanoparticles in biomedical applications: a review on decades of research.","authors":"Suman Mondal, Sangita Mandal, Kabirul Islam Mollah, Avijit Kumar Dey, Debajit Dewan, Biplab Debnath, Suman Sahu, Anup Kumar Sahoo, Soma Jana","doi":"10.1080/09205063.2025.2567924","DOIUrl":"https://doi.org/10.1080/09205063.2025.2567924","url":null,"abstract":"<p><p>Mucilages are polysaccharide hydrocolloids with distinct physicochemical and structural diversity, possessing characteristic functional and health benefits as nanoparticles. Among the numerous polysaccharide hydrocolloids developed to formulate polymeric nanoparticles, mucilage has attracted considerable attention due to its appealing properties: (i) biodegradability and biocompatibility, (ii) facilitating targeted delivery, (iii) reusable (v) scope of controlled release, (vi) probability to modify surface properties, (vii) coating for nanoparticles, (viii) enhancing drug solubility, (ix) low cost, (xi) high water-binding capacity, (xii) cheap and easily available, and (xi) generally recognized as safe for human consumption. This review presents different preparation methods for mucilage-based nanoparticles (MNPs) from the methodological point of view. The crosslinking agents including citric acid, calcium chloride, glutaraldehyde, zinc chloride, and other cross-linkers, and the physicochemical behavior of MNPs including drug loading, drug release, particle size, zeta-potential and stability are briefly discussed. This review also presents MNPs as drug delivery systems in various biomedical applications over the decades. Finally, modifications of MNPs and MNPs nanocomplexes are additionally studied.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-34"},"PeriodicalIF":3.6,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyherbal formulations and phytosome-based delivery in diabetic wound healing: an integrative review.","authors":"Ananda Kumar Chettupalli, Sarad Pawar Naik Bukke, Jai Vardhan, Shika Yadhav, Bharath Kumar Mamilla Mugaiahgari, Patibandla Jahnavi, Vinod Kumar Yata, Bayapa Reddy Narapureddy","doi":"10.1080/09205063.2025.2568684","DOIUrl":"https://doi.org/10.1080/09205063.2025.2568684","url":null,"abstract":"<p><p>Diabetic foot ulcers are a global health concern due to their high prevalence, chronicity, risk of infection, and recurrence. Alternative therapy is necessary since clinical outcomes are poor despite prescribed treatments such as debridement, antibiotic medication, and revascularization. A growing number of researchers are looking at plant medicines as potential new adjuvant or supplementary treatments; the topic includes polyherbal preparations and innovative nanocarrier platforms. This review aims to evaluate the pharmacological action, formulation strategy, and translation potential of polyherbal formulations and phytosome-based drug delivery with a focus on their potential for use in DFU therapy. The anti-inflammatory, antioxidant, antibacterial, and pro-angiogenic effects of polyherbal formulations, including <i>Curcuma longa, Azadirachta indica, and Centella asiatica</i>, work in tandem to accelerate the healing process once a wound has occurred. Vesicular carriers derived from phospholipids, phytosomes, improve the skin's absorption of phytoconstituents and their medicinal efficacy by increasing their solubility, stability, and bioavailability. New research from both animal and human studies indicates that herbal actives encased in phytosomes can influence inflammatory pathways, speed up re-epithelialization, and enhance collagen synthesis. The necessity for standardization of herbal products, regulatory hurdles, and insufficient broad clinical validation are some of the current challenges that this research highlights further. It concludes by discussing future possibilities in wound care protocols, such as omics-oriented techniques, biomarker-driven individualized treatment, and the use of phytosome-enhanced polyherbal systems. Together, our findings reinforce the notion that polyherbal phytosome formulations have the potential to enhance diabetic wound healing outcomes significantly.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-28"},"PeriodicalIF":3.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation, characterization, evaluation of rosmarinic acid loaded phytophospholipid complex for improved antihypertensive and antihyperglycemic activity.","authors":"Saraswati Prasad Mishra, Shweta Dutta, Bibaswan Mishra, Anshita Gupta","doi":"10.1080/09205063.2025.2568683","DOIUrl":"https://doi.org/10.1080/09205063.2025.2568683","url":null,"abstract":"<p><p>Rosmarinic acid (RA), a naturally occurring polyphenolic compound, exhibits significant antihypertensive and antihyperglycemic properties. However, its therapeutic potential is often limited by poor bioavailability. This study aimed to enhance the bioavailability and efficacy of RA by formulating a rosmarinic acid-phytophospholipid complex (RA-PC) using the solvent evaporation method. The complex was characterized using X-ray diffraction (XRD), Transmission electron microscopy (TEM), Differential scanning calorimetry (DSC), zeta potential analysis, and Fourier-transform infrared spectroscopy (FTIR) to confirm its formation and assess its physicochemical properties. Comparative biological assays were conducted to evaluate the antihypertensive and antihyperglycemic activities of pure rosmarinic acid (PRA) and RA-PC against standard drugs, captopril and acarbose, respectively. The results demonstrated that RA-PC exhibited significantly enhanced efficacy compared to PRA. The observed improvement is attributed to the phospholipid layer in RA-PC, which facilitates better permeation through biological membranes and increases RA's bioavailability. The study concludes that phytophospholipid complexation is a promising strategy for overcoming the limitations associated with the bioavailability of herbal compounds. The RA-PC formulation not only enhanced the therapeutic efficacy of RA but also suggests a broader potential for the application of phytophospholipid complexes in the development of herbal drug delivery systems. These findings open avenues for further research into optimizing and scaling up such formulations for clinical use.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nerolidol loaded beta cyclodextrin nanoparticles: a promising strategy for inducing apoptosis in breast cancer cells (MCF-7).","authors":"Kamalesh Balakumar Venkatesan, Saravanan Alamelu, Manoj Kumar Srinivasan, Pugalendhi Pachaiappan","doi":"10.1080/09205063.2025.2491605","DOIUrl":"10.1080/09205063.2025.2491605","url":null,"abstract":"<p><p>This study investigates the synthesis, characterization and anticancer efficacy of nerolidol-loaded beta cyclodextrin polymeric nanoparticles (NER-βCD-NPs) against MCF-7 breast cancer cells. Nerolidol, a sesquiterpene with anti-inflammatory, antioxidant, antimicrobial and anticancer properties, faces challenges of poor solubility and bioavailability, limiting its therapeutic potential. Breast cancer, a leading cause of cancer-related deaths in women, necessitates alternative therapies with fewer side effects compared to conventional chemotherapy. NER-βCD-NPs were synthesized and characterized using UV-visible spectroscopy, fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta potential analysis and differential scanning calorimetry (DSC). Drug encapsulation efficiency and <i>in vitro</i> release were analyzed using HPLC, while molecular docking assessed NER-βCD interactions. Characterization confirmed successful nanoparticle synthesis. UV-visible spectra and FTIR indicated encapsulation-specific changes, SEM revealed surface morphology, and DLS, zeta potential and DSC analyses demonstrated increased size and stability. The encapsulation efficiency was 84.9%, with 86% NER release at pH 5.4 over 48 h. Docking studies supported strong binding between NER and βCD (binding energy: -3.55 kcal/mol). Cytotoxicity assays showed significant MCF-7 cell inhibition. Mechanistic studies revealed reactive oxygen species (ROS) generation, mitochondrial dysfunction, nuclear changes and cell cycle arrest in the G0-G1 phase. Molecular analysis demonstrated apoptosis through upregulation of Bax, Caspase 6, Caspase 9 and Cytochrome c, alongside Bcl-2 downregulation. These results highlight NER-βCD-NPs as a promising strategy for breast cancer therapy, offering targeted delivery and enhanced therapeutic efficacy while mitigating nerolidol limitations. Further studies are warranted to validate their potential in clinical applications.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2021-2051"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-ionizing (UV and MW)-assisted synthesis of polymeric hydrogels for advanced tissue engineering applications.","authors":"Anca Scărișoreanu, Maria Demeter, Ion Călina, Muhammad Asim Raza","doi":"10.1080/09205063.2025.2486866","DOIUrl":"10.1080/09205063.2025.2486866","url":null,"abstract":"<p><p>Significant efforts are underway to develop next-generation biomaterials through clean processes, accelerating the transition from innovative materials to tissue engineering (TE) applications and providing new alternatives for complex tissue repair. A crucial aspect of TE is selecting appropriate matrix materials with optimal physical and bioactive properties for scaffold development. For this purpose, polymers have repeatedly proven effective in creating suitable structures for successful TE applications. In this respect, ultraviolet (UV) and microwave (MW)-assisted synthesis has emerged as promising approaches in TE, offering improved material properties and reduced processing times. UV-assisted synthesis provides advantages, such as rapid gelation, customizable characteristics, and compatibility with various biological materials. MW-assisted synthesis accelerates chemical reactions through localized heating, elimination of side reaction products, and enhanced molecular interactions, enabling rapid fabrication of biocompatible materials such as hydrogels, ceramics, and composites. This review explores the effect of UV and MW-assisted synthesis on polymeric hydrogels for advancing novel materials in TE. The paper outlines the advantages of each technique, including technical specifications of reaction synthesis and recent advancements in UV and MW equipment developments. Additionally, each technique is carefully stated, highlighting hydrogels with enhanced biocompatibility through biological testing, and enhanced efficacy in regenerating soft and hard tissues.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2052-2084"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocrosslinked gelatin methacryloyl/hyaluronic acid methacryloyl composite hydrogels loaded with bone morphogenetic protein 2-black phosphorus nanosheets for bone regeneration.","authors":"Jiaming Wang, Mingchong Liu, Chensong Yang, Xixi Huang, Chenyu Lin, Yuqian Zhu, Jing Wang, Hongyi Zhang, Bingdi Chen, Guixin Sun","doi":"10.1080/09205063.2025.2489846","DOIUrl":"10.1080/09205063.2025.2489846","url":null,"abstract":"<p><p>Black phosphorus nanosheets (BP) have been widely used in bone tissue engineering due to their superior properties and good biocompatibility, as well as the fact that they are composed of only a single element of phosphorus, which is highly homologous to the inorganic components of natural bone. Hydrogels based on gelatin methacryloyl (GelMA)/hyaluronic acid methacryloyl (HAMA) composites were prepared by photocrosslinking. The physicochemical properties of the prepared GelMA/HAMA, GelMA/HAMA/BP, GelMA/HAMA/BMP₂ and GelMA/HAMA/BP@BMP₂ hydrogels were characterized using Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). In addition, the mechanical properties, swelling rate and degradation rate of the hydrogels were investigated, and the results showed that GelMA/HAMA/BP@BMP₂ possessed good physicochemical and mechanical properties, which were suitable for cell adhesion growth and proliferation. BP as a carrier could ensure the stable and sustained release of the bioactive factor: bone morphogenetic protein 2 (BMP₂), which could promote the recruitment and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and its degradation and binding to surrounding calcium ions can promote biomineralization. Therefore, this BMP₂-modified black phosphorus hydrogel system provides a new strategy for bone regeneration.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1962-1984"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characterization of advancing wound care with PVP/QCS/DEX hydrogels: a multifunctional wound dressing composite: <i>in vitro</i> and <i>in vivo</i> assay.","authors":"Masoumeh Hatami, Mohammad Taghi Khorasani, Ebrahim Ahmadi, Sonia Mohamadnia","doi":"10.1080/09205063.2025.2487655","DOIUrl":"10.1080/09205063.2025.2487655","url":null,"abstract":"<p><p>Although the skin has a high healing capacity, severe skin wounds often require external interventions to heal properly. Tissue-engineered wound dressings have indeed gained significant attention among various treatment strategies for wound healing. This study focuses on the integration of polyvinyl pyrrolidone (PVP), quaternized chitosan (QCS), and dextran (DEX) to prepare a ternary composite (PVP/QCS/DEX) as a wound dressing hydrogels with varying concentration of PVP and DEX. A variety of analytical methods, including infrared spectroscopy (FTIR), scanning electron microscopy (SEM), contact angle, and water vapor transmission rate (WVTR) were employed to assess the characteristics of the samples. The uniform and interconnected porous structure of the samples was confirmed by the SEM results. All the samples showed high porosity and water vapor transition rate, demonstrating their ability to provide a suitable moist environment and efficient exudate handling for wound healing. The antibacterial test conducted on hydrogels demonstrated the antibacterial activity of hydrogels and drug-loaded hydrogel samples including <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. The <i>in vitro</i> cytotoxicity evaluation using the MTT assay demonstrated that the developed PVP/QCS/DEX hydrogels exhibit satisfactory cytocompatibility and promote cell viability. The results of the scratch assay indicated that the samples had promoted the cell migration and would improve and accelerate wound healing process. The <i>in vivo</i> healing tests conducted by the drug-loaded hydrogel sample revealed a promising healing performance. Therefore, based on the favorable performance observed throughout the various tests and analysis, the as-prepared PVP/QCS/DEX hydrogels show significant promise in the field of wound dressings.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1931-1961"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tamarind seed polymer-based formulations: advances and applications in biomedical science.","authors":"Ramya Sri, Tanmoy Ghosh, Basavaraj B V, Lakshmi Priya P","doi":"10.1080/09205063.2025.2491604","DOIUrl":"10.1080/09205063.2025.2491604","url":null,"abstract":"<p><p>Tamarind seed polymer has garnered significant attention in biomedical science due to its exceptional properties, like biocompatibility, biodegradability, and adaptability for drug delivery. Derived from tamarind seeds, tamarind gum, a natural polysaccharide, shows great potential as a gelling agent for controlled drug release. Its versatility makes it suitable for delivering both water-soluble and water-insoluble drugs. This opens up exciting opportunities in areas such as oral drug delivery, wound healing, tissue regeneration, anti-inflammatory treatments, and ophthalmic drug delivery. Tamarind seed-based formulations have the remarkable ability to modify drug release rates, enhance drug stability, and improve bioavailability, making them a promising option for advancing healthcare. This review delves into the advancements and ongoing research surrounding tamarind seed polymer systems, highlighting their diverse applications and untapped potential in the biomedical and pharmaceutical fields.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2085-2108"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carboxymethyl bacterial cellulose electrospun nanofibers loaded with zinc oxide nanoparticles and polyhexamethylene biguanide for wound healing promotion.","authors":"Neda Molaee, Shohreh Fahimirad, Ali Ganji, Hamid Abtahi","doi":"10.1080/09205063.2025.2490079","DOIUrl":"10.1080/09205063.2025.2490079","url":null,"abstract":"<p><p>This study explores the development of a novel wound dressing incorporating bacterial cellulose (BC) produced by <i>Acetobacter xylinum</i>, which was carboxymethylated to enhance its biomedical applicability. Zinc oxide nanoparticles (ZnONPs) were biosynthesized using a green method with <i>Quercus infectoria</i> gall extracts (QIG). The composite dressing, composed of BC and polyurethane (PU) nanofibers, was further functionalized with ZnONPs and polyhexamethylene biguanide (PHMB) to provide enhanced antibacterial and wound healing properties. The PU/BC/ZnONPs/PHMB nanofiber mat exhibited strong antibacterial activity against Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), with inhibition zones of 28 and 29 mm for PU/BC/ZnONPs and PU/BC/ZnONPs/PHMB, respectively, surpassing the 12 mm inhibition zone of the Cefoxitin control. The nanofibers had an optimal mean diameter of 71.12 nm, ensuring a high surface area for cell attachment. Mechanical tests confirmed excellent tensile strength and flexibility, while an optimized water vapor transmission rate (∼2000-3000 g/m²/day) facilitated a moist wound environment for enhanced healing. L929 fibroblast studies demonstrated high cell viability (∼95-98%) and enhanced migration, confirming the nanofiber mat's biocompatibility. <i>In vivo</i> wound healing tests showed that PU/BC/ZnONPs/PHMB significantly accelerated wound closure, achieving 90-100% healing by day 10, outperforming PU and PU/BC groups. Bacterial counts were significantly reduced, with complete bacterial inhibition observed by day 5. In conclusion, the PU/BC/ZnONPs/PHMB nanofiber dressing demonstrated superior antibacterial activity, mechanical strength, moisture regulation, and wound healing potential, making it a promising candidate for advanced clinical wound management.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1985-2020"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}