Journal of Biomaterials Science, Polymer Edition最新文献

{"title":"Biocompatibility and biodegradability of multilayered polymeric materials for tissue regeneration.","authors":"Anna D Kosova, Maria Y Naumenko, Sergei G Zhuravskii, Galina Y Yukina, Elena G Sukhorukova, Petr P Snetkov, Svetlana N Morozkina","doi":"10.1080/09205063.2026.2722172","DOIUrl":"https://doi.org/10.1080/09205063.2026.2722172","url":null,"abstract":"<p><p>The tissue regeneration, especially the tympanic membrane regeneration, remains a significant challenge in otorhinolaryngology, necessitating the development of the advanced biomaterials. This study evaluates the biocompatibility and biodegradation of three novel multi-layer polymer scaffolds: KPC (carboxymethyl cellulose/polyethylene oxide/polyvinylpyrrolidone/chitosan), PHC (pullulan/hyaluronic acid/chitosan), and HCA (hyaluronic acid/chitosan/alginate), that designed as biomimetic matrices for tissue repair. The materials were subcutaneously implanted into Wistar rats for 21st and 45th days, with histological evaluation of the peri-implant fibrous capsule. All polymeric matrices underwent biodegradation, with a chronic aseptic inflammatory response characterized by macrophage and lymphocyte infiltration within the fibrous capsule. However, the severity and dynamics of the inflammation were highly dependent on material content. The KPC matrix induced the mildest cellular reaction, which significantly subsided by the day 45th, accompanied by the formation of mature collagen layers and an absence of giant multinucleated foreign body giant cells. In contrast, PHC and HCA matrices provoked more pronounced and sustained inflammation, with PHC showing intensification at the later point linked to accelerated bioresorption and the presence of numerous spherical degradation products. Mast cell involvement was minimal for KPC but notable within the capsule for PHC and HCA at the 45th day. In conclusion, while all tested composites are biodegradable, the KPC formulation demonstrates superior biocompatibility with a self-limiting inflammatory response, making it the most promising candidate for further development of regenerative implant for middle ear reconstruction.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-29"},"PeriodicalIF":3.5,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology-enabled delivery of bioactive compounds for neuroprotection in Parkinson's disease: mechanisms and future directions.","authors":"Praveen Gaur, Prachee Raje Bisht, Sonia Lal Gupta","doi":"10.1080/09205063.2026.2723464","DOIUrl":"https://doi.org/10.1080/09205063.2026.2723464","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a neurodegenerative disorder marked by the progressive loss of dopaminergic neurons in the substantia nigra. Its clinical features include motor symptoms such as tremor, bradykinesia, rigidity, and postural instability. The pathophysiology of PD involves oxidative stress, mitochondrial impairment, neuroinflammation, protein misfolding, and aberrant alpha-synuclein aggregation, which disrupt dopaminergic signaling pathways. Biomarkers such as α-synuclein, DJ-1, neurofilament light chain, and imaging biomarkers such as DAT-SPECT are being studied for early diagnosis, evaluation of disease progression, and therapy monitoring. Although advancements have been made, current options-such as dopamine replacement therapy, deep brain stimulation, and physiotherapy-remain largely symptomatic, carry long-term side effects, and fail to halt disease progression. Nanotechnology advancements have brought a major paradigm shift in the management of PD. Curcumin, Resveratrol, and EGCG are bioactive compounds with antioxidant, anti-inflammatory, and neuroprotective properties. However, their clinical use is limited because of poor bioavailability and stability. Nanocarrier systems such as liposomes, dendrimers, and polymeric nanoparticles improve targeted delivery through the blood-brain barrier. This helps in reducing systemic toxicity and enhancing therapeutic effectiveness. The therapeutic mechanism of these nanoformulations mainly involves free radical scavenging, modulation of mitochondrial function, inhibition of α-synuclein fibril formation, and regulation of cell signal transduction pathways such as Nrf2/ARE and NF-κB. The major challenges include large-scale production, long-term safety assessment, regulatory challenges, and site-specific delivery. Future research is moving toward the convergence of gene therapy, nanomedicine, and precision targeting to develop disease-modifying therapy. This approach aims not only to control symptoms but also to potentially control neurodegeneration in PD.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-31"},"PeriodicalIF":3.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thickness- and environment-dependent hydrolytic degradation of semi-crystalline poly(L-lactic acid) esophageal stents: a computational-experimental investigation.","authors":"Saeed Sanjari, Shahram Etemadi Haghighi, Payam Saraeian, Ali Alinia-Ziazi","doi":"10.1080/09205063.2026.2722155","DOIUrl":"https://doi.org/10.1080/09205063.2026.2722155","url":null,"abstract":"<p><p>Predicting the hydrolytic degradation of semi‑crystalline biodegradable polymers remains challenging due to hydrolysis kinetics, transport of degradation products, and structural dimensions. Here, a coupled computational-experimental framework is developed, calibrated, and assessed using accelerated <i>in‑vitro</i> degradation experiments to quantitatively describe the spatio‑temporal evolution of number‑average molecular weight (<math><mrow><msub><mrow><mi>M</mi></mrow><mrow><mi>n</mi></mrow></msub></mrow></math>) and crystallinity (<math><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>c</mi></mrow></msub></mrow></math>) in full‑scale poly(L‑lactic acid) (PLLA) structures. A Multiphysics degradation model accounting for hydrolytic chain scission, diffusion of acidic by‑products, and morphology‑dependent transport is employed and assessed against time‑resolved experimental data. Under accelerated boundary conditions (BC‑1), both thin (0.8 mm) and thick (1.6 mm) stents exhibit nearly identical degradation kinetics, with comparable <math><mrow><msub><mrow><mi>M</mi></mrow><mrow><mi>n</mi></mrow></msub></mrow></math> decay rates and degradation half‑life of approximately 24-25 days, indicating similar degradation behavior in this regime despite thickness‑dependent autocatalytic effects in thicker geometries. In contrast, simulations under quasi‑physiological conditions (BC‑2) predict a non‑classical thickness effect, whereby the thicker stent reaches the degradation half‑life approximately 30%-40% earlier than the thinner counterpart (144 days versus 220 days). Spatio‑temporal analyses reveal a bulk‑erosion‑dominated degradation mechanism with localized surface‑to‑core gradients, governed by diffusion limitations and accumulation of acidic degradation products that enhance autocatalytic hydrolysis in larger volumes. The model shows strong agreement with experimental <math><mrow><msub><mrow><mi>M</mi></mrow><mrow><mi>n</mi></mrow></msub></mrow></math> (<math><mrow><msup><mrow><mi>R</mi></mrow><mrow><mn>2</mn></mrow></msup></mrow></math>  ≈  0.92-0.97), deviations in late‑stage <math><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>c</mi></mrow></msub></mrow></math> reflect competition between degradation and crystallization, with degradation dominating, and mass‑loss and fragmentation not captured in the current formulation. Overall, this work provides quantitative insight into thickness‑ and environment‑dependent degradation behavior of semi‑crystalline polymers and establishes a predictive materials‑level framework for assessing long‑term degradation and lifetime of biodegradable polymeric systems.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-25"},"PeriodicalIF":3.5,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-assisted prediction of swelling behavior in sodium alginate/triethylene glycol/acrylic acid pH-responsive biodegradable hydrogels.","authors":"S Sudarsan, S Guhanathan, M Anandkumar, Komal Kumar Napa","doi":"10.1080/09205063.2026.2722164","DOIUrl":"https://doi.org/10.1080/09205063.2026.2722164","url":null,"abstract":"<p><p>pH-responsive hydrogels have attracted considerable attention for biomedical applications because of their ability to undergo controlled swelling under varying environmental conditions. However, accurately predicting swelling behavior remains challenging due to the complex nonlinear interactions between pH and swelling kinetics. In this study, sodium alginate/triethylene glycol/acrylic acid (STA) biodegradable hydrogels were investigated, and an optimized machine learning framework was developed to predict their swelling behavior under different pH conditions. Experimental swelling data collected over 10-360 min at pH 4, 6, 7.4, 8, and 10 were modeled using an optimized Gradient Boosting regression algorithm with engineered physicochemical features and randomized hyperparameter optimization under 10-fold cross-validation. The optimized model achieved excellent predictive performance with a coefficient of determination (R²) of 0.9617, a root mean square error (RMSE) of 202.22, and a mean absolute error (MAE) of 116.36, demonstrating strong agreement between experimental and predicted swelling values. Feature importance and SHapley Additive exPlanations (SHAP) analyses identified nonlinear time-dependent descriptors and pH-time interaction features as the dominant factors governing swelling prediction, improving model interpretability. The proposed framework provides an accurate, interpretable, and computationally efficient tool for hydrogel swelling prediction, supporting the rational design and optimization of pH-responsive biomaterials.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.5,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering core-shell polymer microgels to control the onset of glucose-regulated insulin release.","authors":"Yingyu Li, Koushik Bhattacharya, Jiangtao Zhang, Snehashis Roy, Prashun G Roy, Jing Shen, Shuiqin Zhou","doi":"10.1080/09205063.2026.2722159","DOIUrl":"10.1080/09205063.2026.2722159","url":null,"abstract":"<p><p>Intelligent insulin delivery systems have been a longstanding goal for effective diabetes management with minimized risk of hypoglycemia and reduced discomfort of finger pricks and injections. In this study, core-shell structured microgels are designed to regulate insulin release at physiologically relevant glucose levels. Specifically, a copolymer microgel of poly[(N-isopropylacrylamide)-<i>co</i>-acrylamide-<i>co</i>-(2-acrylamidomethyl-5-fluorophenylboronic acid)] [p(NIPAM-AAm-FPBA)] is prepared as the core to facilitate glucose sensitivity at physiological pH. The neutral hydrophilic poly[oligo(ethylene glycol) methyl ether methacrylate] (pOEGMA) gel shell is added onto the core microgel to enhance the insulin loading capacity and control the glucose-responsive properties of the resultant core-shell microgels. The thickness of the pOEGMA shell directly influences the glucose concentration required to initiate the volume phase transition of the core-shell microgels, allowing for tunable onset (or 'gate') of glucose-responsive insulin release. Insulin molecules remain encapsulated within the microgels under hypo- and normoglycemic conditions but are efficiently released in hyperglycemic conditions in response to elevated glucose levels. The pOEGMA-shelled microgels exhibit no cytotoxicity <i>in vitro</i>. Such core-shell microgels highlight their potential as an effective intelligent insulin delivery platform.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-21"},"PeriodicalIF":3.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148828593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation, optimization, and preclinical assessment of a QbD-engineered transethosomal pregabalin patch for neuropathic pain.","authors":"Janita Safdar, Naveed Ahmed, Syeda Komal Fatima, Parsa Gul, Asim Ur Rehman","doi":"10.1080/09205063.2026.2722168","DOIUrl":"https://doi.org/10.1080/09205063.2026.2722168","url":null,"abstract":"<p><p>Neuropathic pain is a major clinical challenge since it has complex pathophysiology and multifactorial etiology. Pregabalin is an anticonvulsant drug that binds with the α2δ subunit of voltage-gated calcium channels, decreases their influx, and eventually lowers the release of excitatory neurotransmitters. The conventional oral Pregabalin exhibits lower therapeutic efficacy because of its variable absorption, CNS side effects, and frequent dosing. This present study suggests a new transdermal formulation containing transethosomes loaded with pregabalin to provide sustained drug release, enhanced drug penetration into the skin, and subsequently reduced systemic side effects. Transethosomes were formulated by thin-film hydration method, and their optimization was done through Box Behnken design, which recorded optimal particle size of 124.4 ± 2.54 nm, zeta potential of -20.5 ± 0.35 mV, and entrapment efficiency of 83.4 ± 0.8%. Formulation was then added to a transdermal patch containing eucalyptus oil and checked for <i>in vitro</i> release, which revealed that PGB-TES-P + EO showed more sustained drug release. Enhanced transdermal penetration of PGB-TES-P + EO was proved by <i>ex vivo</i> permeation and through fluorescence microscopy. <i>In vivo</i> assessment in the streptozotocin-induced diabetic neuropathic pain model demonstrated significant improvement in locomotor activity and pain responses, as well as a decline in the proinflammatory markers such as TNF-α and COX-2, which post-treatment values of 120.5 ± 6.57 and 119.1 ± 2.82, respectively. The final formulation showed no irritation to the skin and was found to be stable according to the ICH guidelines. Altogether, this system presents a potential alternative for non-invasive delivery for Pregabalin with improved drug permeation in neuropathic pain management.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-27"},"PeriodicalIF":3.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction, structural characterization and biofunctional evaluation of novel chitosan derived from freshwater copepod <i>Thermocyclops decipiens</i> for biomedical applications.","authors":"Sivakumar Kandhasamy, Sowmiya Thirthapathy, Suzanna Christy Pancras, Reshma Dhavithu, Gowthami Ganesan, Meenakshi Sivalingam Valliappan","doi":"10.1080/09205063.2026.2722160","DOIUrl":"https://doi.org/10.1080/09205063.2026.2722160","url":null,"abstract":"<p><p>Chitosan is a known biopolymer for biomedical applications, but its reliance on classical crustacean sources can lead to sustainability and variability problems. This is the first study to extract chitosan from a freshwater cyclopoid copepod (<i>Thermocyclops decipiens</i>) and characterise it in detail with respect to its physicochemical and biological properties. Chitosan was extracted from <i>T. decipiens</i>, and FTIR confirmed a degree of deacetylation (DA) of 78.7%. Structural characterization indicated that the functional groups were regular, and subsequent X-ray diffraction (XRD) analysis supported a semi-crystalline structure with lower crystallinity and higher solubility. The elemental composition obtained from the EDAX analysis, which included carbon (46·92%) and oxygen (47·56%) with residual elements, was correlated to the porous structure detected by SEM. Thermogravimetric analysis (TGA) revealed several degradation phases with large-scale decomposition from 250 to 350 °C, indicating that the scaffolds displayed high thermal stability. Biological evaluations demonstrated high cytocompatibility of the materials (≥99% cell viability). Highly effective healing was observed at 48 h due to the material, with 22.31% closure and significant upregulation of genes involved in angiogenesis, such as VEGF (21-fold), modest activation of PI3K signaling (1.38-fold), and no significant change in HIF expression, suggesting that this healing is mediated <i>via</i> angiogenesis. Activity was dose dependent with greatest inhibition zones measuring 12·2 mm (<i>E. coli</i>) and 7·9 mm (<i>E. faecalis</i>). Hemocompatibility studies also indicated degree of hemolysis, ranging from 1.10-12.19%. These findings establish <i>T. decipiens</i> as a novel, environmentally friendly source of chitosan that has sustainability and biocompatibility in the biomedical regenerative space.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-29"},"PeriodicalIF":3.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148828687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robust macroporous starch hydrogel/eggshell biocomposites as sustainable scaffolds.","authors":"Zeynep Ak, Burcin Izbudak, Esra Su, Ayca Bal Ozturk, Mehmet Murat Ozmen","doi":"10.1080/09205063.2026.2722156","DOIUrl":"https://doi.org/10.1080/09205063.2026.2722156","url":null,"abstract":"<p><p>Mechanically robust biomaterials offer significant promise for bone scaffolds; however, there remains a pressing need for alternatives that are well-characterized, cost-effective, and derived from sustainable sources. In this study, we developed a mechanically reinforced and sustainable macroporous hydrogel biocomposite by integrating starch, a low-cost natural polymer with favorable mechanical characteristics, with waste eggshell particles known for their ability to promote biomineralization. Starch-based matrices containing varying amounts of eggshell particles were fabricated <i>via</i> ice-templating and subsequently subjected to a post-crosslinking step using polyethylene glycol diglycidyl ether (PEGDE), a critical process that confers structural stability to the resulting hydrogel. Starch hydrogel eggshell biocomposites were characterized morphologically, chemically, mechanically, and biologically by SEM, swelling, FTIR, compression, biocompatibility, biomineralization, and biodegradation studies. While FTIR results confirmed successful post-crosslinking of the hydrogels, the mechanical tests revealed that inclusion of particles led to an almost threefold increase in Young's modulus compared to the control sample. SEM images displayed an open macroporous structure with pore sizes in the range of 48-261 µm. SEM-EDX analysis showed no mineral accumulation in the control sample, whereas eggshell-containing samples achieved a calcium content of up to 8.6 ± 0.2%. The MTT assay demonstrated improved cell viability in scaffolds with eggshell particles, and biodegradation tests revealed a reduced degradation rate in these scaffolds. Thus, the incorporation of eggshell particles, combined with post-crosslinking of the starch matrix, led to the formation of a mechanically strong, sustainable, cost-effective hydrogel scaffold with potential applicability in bone tissue engineering.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-19"},"PeriodicalIF":3.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From extreme environments to skin interfaces: thermophilic exopolysaccharides as smart and sustainable polymers for advanced cosmeceutical and transdermal applications.","authors":"Shuddhasattwa Choudhury, Vishal Kumar Singh, Komal Naina, Khushi Kumari, Shubha Rani Sharma","doi":"10.1080/09205063.2026.2722161","DOIUrl":"https://doi.org/10.1080/09205063.2026.2722161","url":null,"abstract":"<p><p>Microbial exopolysaccharides (EPS) possess strong potential for next-generation biomaterials due to their sustainability, biodegradability, and biocompatibility as the promising replacements for fossil-derived polymers. Conventional synthetic and semi-synthetic polymers have been used for pharmaceutical and cosmetic applications but due to their limitations-particularly in advanced skin-interface technologies-the need for safe and environmentally friendly alternatives has emerged. Thermophilic microorganisms, which have high growth activity in extreme conditions and synthesize extracellular polymeric substances (EPS) as materials that are functionally acting as protective matrix structures outside the cell, seem to be the most promising natural solution. The latter type of EPS has unique physicochemical characteristics, such as thermal stability and viscosity, in addition to certain functional groups. Such properties enable their use in complex applications (e.g. hydrogels, nanoparticles, and hybrid delivery systems), where they benefit on drug stability, skin permeation, and unwanted effects. Regarding composition, EPS are polysaccharides comprising repeating monosaccharide units linked by glycosidic bonds. These polymers possess valuable intrinsic properties that make them highly attractive for pharmaceutical, cosmetic and food industries such as biodegradability, non-toxicity and tunable properties. In contrast to plant-derived polysaccharides, microbial EPS accumulate in a highly controlled manner with predictable and reproducible qualities that lend themselves to large-scale biotechnological production. Current limitations like production cost and downstream processing will likely be overcome by future advances in biotransformation biotechnology and process optimization. Translating the need for EPS-based materials into commercially viable and sustainable solutions of future application will require great cooperation among researchers, industry and regulatory bodies.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-27"},"PeriodicalIF":3.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freeze-dried porous PVA-gelatin scaffold incorporated with FSIC bioactive material for wound healing applications.","authors":"M Mahesh Yadav, Fatima Sanjeri Dasankoppa, Somashekara M Adinarayanappa, Hasanpasha N Sholapur, M A Umarfarooq, Revati Dharampal Sagare","doi":"10.1080/09205063.2026.2722206","DOIUrl":"https://doi.org/10.1080/09205063.2026.2722206","url":null,"abstract":"<p><p>The present study aimed to develop and optimize a freeze-dried porous scaffold incorporated with FSIC bioactive material for wound healing applications. A 2³ full factorial design was employed to optimize scaffold composition using polyvinyl alcohol (PVA), bioactive material, and gelatin concentrations as independent variables, while swelling index and tensile strength were selected as optimization responses. The optimized scaffold was prepared by solvent casting followed by freeze-drying and characterized using FTIR, XRD, DSC, FESEM, and EDS analyses. The optimized bioactive scaffold consisted of 5.24% w/v PVA, 1.28% w/v bioactive material, and 2.93% w/v gelatin. The scaffold exhibited high swelling capacity (1218 ± 52%), porosity (84.6 ± 2.3%), controlled degradation behavior, and suitable mechanical stability. FESEM analysis demonstrated a highly porous interconnected architecture, while XRD and EDS analyses confirmed successful incorporation of the FSIC bioactive material within the scaffold matrix. The scaffold exhibited antibacterial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> with inhibition zones of 23.0 ± 0.8 mm and 20.0 ± 0.6 mm, respectively. In addition, the scaffold demonstrated good hemocompatibility, high cytocompatibility, enhanced cell migration, accelerated wound contraction, and improved wound healing in the <i>in vivo</i> excision wound model. Biochemical evaluation further confirmed reduced inflammatory cytokine expression and enhanced collagen deposition in the scaffold-treated group. The obtained findings demonstrated that the developed porous bioactive scaffold possesses promising physicochemical and biological properties suitable for wound healing and tissue regeneration applications.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}