Journal of Biomaterials Science, Polymer Edition最新文献

Rapidly self-crosslinking sodium alginate hydrogel for infected wounds.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-01-06 DOI: 10.1080/09205063.2024.2438497

Yongze Liu, Mei Li, Genyuan Li, Lei He, Xiaofeng Ma, Zhaoxiang Zhang, Jun Zhang

引用次数: 0

Gallic acid-guar gum and chitosan-based polyelectrolyte complex film exhibited enhanced wound healing in full-thickness excision wound model.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-01-06 DOI: 10.1080/09205063.2024.2439668

Vinita Patole, Dhaneshwari Swami, Ganesh Ingavle, Isha Behere, Divya Ottoor, Nikita Vyawahare, Abhishek Jha, Sanjeevani Deshkar, Vaishali Undale, Avinash Sanap, Supriya Kheur, Avinash Kumar

{"title":"Gallic acid-guar gum and chitosan-based polyelectrolyte complex film exhibited enhanced wound healing in full-thickness excision wound model.","authors":"Vinita Patole, Dhaneshwari Swami, Ganesh Ingavle, Isha Behere, Divya Ottoor, Nikita Vyawahare, Abhishek Jha, Sanjeevani Deshkar, Vaishali Undale, Avinash Sanap, Supriya Kheur, Avinash Kumar","doi":"10.1080/09205063.2024.2439668","DOIUrl":"https://doi.org/10.1080/09205063.2024.2439668","url":null,"abstract":"Recently, there has been a great interest in the development of innovative wound dressing materials based on natural bioactives, as they can accelerate the healing process and address the issues related to traditional wound dressings. The current study focuses on developing a novel derivative of guar gum (GG) and gallic acid (GA) using a simple, free radical-mediated polymerization reaction aimed at enhancing the antioxidant properties of GG. Multiple spectroscopic investigations were performed to validate the GA-GG conjugate. NMR and FTIR confirmed GA integration, UV spectroscopy indicated changes in electronic transition, DSC analysis suggested a reduction in crystallinity, and XRD revealed structural modifications. SEM revealed a porous structure that reflected its polymerized nature. Due to inadequate mechanical strength and film-forming ability of the synthesized GA-GG conjugate, polyelectrolyte complexation method using chitosan was explored to form a polyelectrolyte complex (PEC) film. The film exhibited a high swelling rate, excellent antioxidant properties, and was both hemocompatible and exhibited improved antimicrobial properties. In vitro, in ovo, and in vivo characterizations were performed to compare the performance of these biocomposite films to those of their counterparts. It promoted angiogenesis in the chick yolk sac membrane and demonstrated good cytocompatibility in cell proliferation studies on the viability of the L929 mouse fibroblast cell line. In vivo wound healing efficacy of the PEC film in wound closure was 94.5% as compared to the untreated disease control group (p < 0.001). This work highlights the development of an innovative GA-GG conjugate/chitosan PEC-based film with significant potential for wound healing applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-34"},"PeriodicalIF":3.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zein-based nanoparticulate systems: a journey through fabrication, targeting strategies and biomedical applications.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-01-02 DOI: 10.1080/09205063.2024.2438493

Shyam Sudhakar Gomte, Rushikesh Sanjay Shewale, Mayur Kedarnath Vidhate, Tejas Girish Agnihotri, Vasu Peddinti, Biswajit Rout, Swarnlata Saraf, Aakanchha Jain

{"title":"Zein-based nanoparticulate systems: a journey through fabrication, targeting strategies and biomedical applications.","authors":"Shyam Sudhakar Gomte, Rushikesh Sanjay Shewale, Mayur Kedarnath Vidhate, Tejas Girish Agnihotri, Vasu Peddinti, Biswajit Rout, Swarnlata Saraf, Aakanchha Jain","doi":"10.1080/09205063.2024.2438493","DOIUrl":"https://doi.org/10.1080/09205063.2024.2438493","url":null,"abstract":"Zein, a plant-based protein obtained from the endosperm of corn (Zea mays L.) received colossal attention in recent years due to its promising features like being economical, mucoadhesive, gastro-resistant, biocompatible and aids to load hydrophilic and hydrophobic therapeutic agents. It can be employed for the fabrication of various drug delivery systems such as nanoparticles, micelles, hydrogels, nanofibers and films. These systems help to stabilize zein making it suitable for a wide range of applications in the food, cosmetic, and pharmaceutical industries. Diverse techniques could be employed in the development of zein-based nanoparticulate systems such as antisolvent technique, electro-spraying, pH-driven, solvent emulsification, spray drying and flash nanoprecipitation. For the efficient targeted delivery of zein, a ligand-based strategy (folic acid, hyaluronic acid, peptide, transferrin) and stimuli-responsive approach (pH, temp. light etc.) could be employed. This review article mainly deals with the introduction of various types of zein-based systems followed by a comprehensive understanding of fabrication techniques. Further, we have extensively elaborated targeted strategies used for zein-based nanoparticulate systems in the management of various diseases. Paramountly, the article explored potential biomedical applications of zein-based systems in recent years. and emphasizes the current challenges related to zein-based nanoparticulate systems with a special focus on improvement in further research. We aim to foster an in depth understanding of zein-based systems in drug delivery and lay the foundation for its advancements in the field of the pharmaceutical and healthcare sector.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-48"},"PeriodicalIF":3.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-29 DOI: 10.1080/09205063.2024.2447675

引用次数: 0

Gene expression and hormonal signaling in osteoporosis: from molecular mechanisms to clinical breakthroughs.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-27 DOI: 10.1080/09205063.2024.2445376

Gurinderdeep Singh, Ronald Darwin, Krishna Chandra Panda, Shaikh Amir Afzal, Shashwat Katiyar, Ram C Dhakar, Sangeetha Mani

{"title":"Gene expression and hormonal signaling in osteoporosis: from molecular mechanisms to clinical breakthroughs.","authors":"Gurinderdeep Singh, Ronald Darwin, Krishna Chandra Panda, Shaikh Amir Afzal, Shashwat Katiyar, Ram C Dhakar, Sangeetha Mani","doi":"10.1080/09205063.2024.2445376","DOIUrl":"https://doi.org/10.1080/09205063.2024.2445376","url":null,"abstract":"Osteoporosis is well noted to be a universal ailment that realization impaired bone mass and micro architectural deterioration thus enhancing the probability of fracture. Despite its high incidence, its management remains highly demanding because of the multifactorial pathophysiology of the disease. This review highlights recent findings in the management of osteoporosis particularly, gene expression and hormonal control. Some of the newest approaches regarding the subject are described, including single-cell RNA sequencing and long non-coding RNAs. Also, the review reflects new findings on hormonal signaling and estrogen and parathyroid hormone; patient-specific approaches due to genetic and hormonal variation. Potential new biomarkers and AI comprised as factors for improving the ability to anticipate and manage fractures. These hold great potential of new drugs, combination therapies and gene based therapies for osteoporosis in the future. Further studies and cooperation of scientists and clinicians will help to apply such novelties into practical uses in the sphere of medicine in order to enhance the treatment of patients with osteoporosis.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-36"},"PeriodicalIF":3.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological evaluation of trans-2,3-dihydrofuro[3,2-c]coumarins as potential cathepsin inhibitors and anticancer agents.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-26 DOI: 10.1080/09205063.2024.2441036

Suman Jangra, Neera Raghav, Deepak Wadhwa, Ajay Kumar, Shalmoli Bhattacharyya, Vikram Kumar, Jyoti Sheokand

引用次数: 0

A new path in bone tissue engineering: polymer-based 3D-printed magnetic scaffolds (a comprehensive review of in vitro and in vivo studies).

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-23 DOI: 10.1080/09205063.2024.2444077

Atiyeh Sadat Safavi, Saeed Karbasi

引用次数: 0

Development, in vitro and in vivo evaluation of film forming solutions for transdermal drug delivery of Zaltoprofen.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-23 DOI: 10.1080/09205063.2024.2443332

Prajila Alayadan, Avichal Kumar, Sanjana S Prakash, Babiker Bashir, V Bhagya, S Narasimha Murthy, H N Shivakumar

{"title":"Development, in vitro and in vivo evaluation of film forming solutions for transdermal drug delivery of Zaltoprofen.","authors":"Prajila Alayadan, Avichal Kumar, Sanjana S Prakash, Babiker Bashir, V Bhagya, S Narasimha Murthy, H N Shivakumar","doi":"10.1080/09205063.2024.2443332","DOIUrl":"https://doi.org/10.1080/09205063.2024.2443332","url":null,"abstract":"Zaltoprofen (ZAL) is a non-steroidal anti-inflammatory drug (NSAID) with a short half-life (∼2.8 h) due to extensive first pass metabolism. In this context, 16 different polymeric film forming solutions (PFFS) of ZAL were developed using different grades of Eudragits, Polyvinylpyrrolidones, Kollicoat MAE 100 P and Hydroxypropyl cellulose as film formers, and polyethylene glycol 400 as a plasticizer in equal parts of ethanol and isopropyl alcohol used as solvents. Of these solutions, F13 composed of Kollicoat MAE 100 P emerged as an optimal PFFS as it quickly formed a saturated film (10.25 ± 0.75 min) that displayed low drying time (3.00 ± 0.46 min), and high in vitro adhesion (2.67 ± 0.58). Ex vivo permeation studies conducted in Franz diffusion cell across porcine skin indicated that F13 displayed significantly higher (p < 0.001) steady state flux (8.64 ± 1.72 µg.cm-2.h-1), shorter lag time (∼3 h) and better skin content (2.55 ± 0.62 µg/mg) compared to other PFFS. Fourier Transform Infrared Spectroscopy (FT-IR) proved the chemical integrity of ZAL in polymeric film formed from F13, while Differential scanning calorimetry (DSC) and X-ray Diffractometry (XRD) proved the \"anti-recrystallization potential\" of PFFS. Anti-inflammatory studies in rats indicated that F13 significantly inhibited (ANOVA, p < 0.001) carrageenan induced paw edema for nearly 12 h compared to topical diclofenac used as standard. In addition, significantly elevated (ANOVA, p < 0.001) analgesic effect was noted in the hot plate test in rats treated with F13 compared to the standard for 12 h proving the superior efficacy of F13. Thus, PFFS by virtue of \"in situ evaporative metamorphosis\" induced supersaturation can be an attractive platform to deliver ZAL transdermally.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of chitin dissolution, hydrogel formation and its biomedical applications.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-20 DOI: 10.1080/09205063.2024.2442181

Kavipriya Murugaiyan, Vishnu Priya Murali, Hiroshi Tamura, Tetsuya Furuike, Jayakumar Rangasamy

{"title":"Overview of chitin dissolution, hydrogel formation and its biomedical applications.","authors":"Kavipriya Murugaiyan, Vishnu Priya Murali, Hiroshi Tamura, Tetsuya Furuike, Jayakumar Rangasamy","doi":"10.1080/09205063.2024.2442181","DOIUrl":"https://doi.org/10.1080/09205063.2024.2442181","url":null,"abstract":"Chitin hydrogel and hydrogel-based products are some of the frequently reported biomaterials for biomedical applications. Yet there is a void in understanding chitin's dissolution mechanism and its most suitable solvent system(s). Chitin is a natural polysaccharide polymer which can be dissolved in solvents such as calcium chloride- methanol, sodium hydroxide/urea (NaOH/urea), lithium chloride diacetamide (LiCl/DMAc), ionic liquids and deep eutectic solvents. Among the alkali/urea dissolution systems such as NaOH/urea, KOH/urea, LiOH/urea for dissolution of chitin we will be focussing on NaOH-based system here for ease of comparison with the other systems. Chitin has been used for decades in the biomedical field; however, new solvent systems are still being explored even to this day to identify the most suitable chemical(s) for dissolving it. Chitin, due to its biocompatibility, allows us to use it for multifaceted purposes. Hence, it is important to consolidate the available studies for better understanding about the most sought-after biomaterial. This overview deeply delves into the mechanism of action of the existing solvent systems and highlights its merits and demerits. It discusses the rheological properties of the chitin gel from different solvent systems and puts forth the current biomedical applications of chitin gel in areas such as tissue engineering, drug delivery, biosensing, hemostasis and wound healing. It also outlines recent advances and highlights the potential gaps which need to be addressed in future studies.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization, antimicrobial and antioxidant activity of bee bread encapsulated with chitosan nanoparticle.

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-20 DOI: 10.1080/09205063.2024.2441032

Stanley Nnamdi Ogoh, Erkay Özgör

引用次数: 0