Journal of Biomaterials Science, Polymer Edition最新文献

{"title":"Advancements in polymer-based approaches in diabetic wound healing: a comprehensive review.","authors":"Lakshmi Priya P, Tanmoy Ghosh, Ramya Sri, Basavaraj B V","doi":"10.1080/09205063.2025.2492777","DOIUrl":"https://doi.org/10.1080/09205063.2025.2492777","url":null,"abstract":"<p><p>Diabetes, both Type 1 and Type 2, often leads to chronic wounds due to impaired healing processes, marked by prolonged inflammation, delayed blood vessel formation, and abnormal collagen production. These issues disrupt normal tissue regeneration, slowing healing. To address these challenges, polymer-based wound dressings are being explored as a promising solution. Natural polymers like alginate, chitosan, and hyaluronic acid, as well as synthetic ones like PCL, PLA, and PLGA, offer potential for more effective healing. These materials can be used in advanced delivery systems, such as nanofibrous scaffolds, nanoparticles, and hydrogels, which help deliver medications, maintain a moist healing environment, and stimulate cell growth. By improving the wound environment, polymer-based systems provide new hope for diabetic patients with slow-to-heal wounds, enhancing therapeutic outcomes and accelerating healing. These innovations could significantly improve the management of chronic wounds in diabetes.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-15"},"PeriodicalIF":3.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of curcumin and piperine in cocrystal form: a breakthrough in bladder cancer therapy.","authors":"Durga Polati, Prasad Neerati","doi":"10.1080/09205063.2025.2491606","DOIUrl":"https://doi.org/10.1080/09205063.2025.2491606","url":null,"abstract":"<p><p>Curcumin (CUR) is a promising anticancer agent for urinary bladder cancer (UBC) but is hindered by poor oral bioavailability. This study investigates the role of cocrystal technology in overcoming these limitations through the formation of curcumin-piperine (CUR-PIP) cocrystals (CoCry). The CUR-PIP CoCry was evaluated for its ability to suppress IGF2 over expression in UBC. Molecular interactions were predicted <i>via</i> Auto Dock simulations, and the co crystals were characterized using FTIR, DSC, PXRD, SEM, and ssNMR. Saturation solubility, dissolution, permeability, and <i>in vivo</i> pharmacokinetic studies were conducted. The therapeutic efficacy of CUR-PIP CoCry was tested in a bladder cancer rat model induced by N-Methyl Nitrosourea; with IGF2 expression quantified using qRT-PCR and flow cytometry. The CUR-PIP CoCry demonstrated enhanced drug release and permeability compared to CUR alone. Pharmacokinetic analysis revealed a 5.7-fold increase in C_max and a 7.9-fold increase in AUC_0-12 hr compared to CUR alone. <i>In vivo</i> studies using an MNU-induced bladder cancer rat model demonstrated that CUR-PIP CoCry significantly suppressed IGF2 expression (<i>p</i> < 0.001) and enhanced anticancer efficacy. This study underscores the potential of cocrystallization as a novel approach to enhance bioavailability and therapeutic effectiveness in cancer treatment.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-28"},"PeriodicalIF":3.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced biological properties of polyvinyl alcohol-polycaprolactone/hyaluronic acid-coated electrospun scaffolds for articular cartilage regeneration.","authors":"Omid Fakhraei, Hosein Rostamani, Aida Aliebrahim Nosh Abad, Shaniya Valizadeh, Mohammad Mahdi Bakhshayeshi, Mohammad Rafienia","doi":"10.1080/09205063.2025.2492462","DOIUrl":"https://doi.org/10.1080/09205063.2025.2492462","url":null,"abstract":"<p><p>This study provides a cohesive framework to putting forth PVA-PCL scaffolds coated with hyaluronic acid (HA) hydrogel to mimic the characteristics of articular cartilage, as a cost-effective tissue engineering alternative. PVA and PCL solutions were prepared and electrospun under measured conditions, with parameters adjusted to fabricate aligned and random fiber orientations. Afterward, the scaffold was integrated with the optimal hydrogel, selected for its superior water absorption and hydrophilicity. The thickness of the hydrogel layer satisfied the criteria for supporting chondrocyte function, and the study assesses its effect on cell viability. Scaffolds were characterized using field emission scanning electron microscopy (FE-SEM) for morphology, energy-dispersive X-ray spectroscopy (EDX) for elemental analysis, Fourier transform infrared (FTIR) spectroscopy for chemical composition, and tensile tests for mechanical behavior. The surface wettability was determined by contact angle measurements. Biological properties were assessed through cytotoxicity, protein absorption assays and cell adhesion tests with visualization of cell distribution using DAPI staining, fluorescence microscopy, and FE-SEM. Using a hydrolytic mechanism, biodegradation was assessed using pH variations and weight loss measurements. Accordingly, randomly oriented hydrogel-coated scaffolds yielded the most favorable biological outcomes to produce a tissue-friendly, biologically robust graft that closely mimics the natural cartilage extracellular matrix. The pore size and distribution of these scaffolds were more uniform than those of aligned structures. The findings suggest possibilities for customizing scaffold properties through fiber orientation, polymer blending, and surface coating to optimize cell response and tissue formation. Combining electrospun PVA-PCL with chondrocytes-seeded hydrogels offers a way to improve articular cartilage regeneration.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-29"},"PeriodicalIF":3.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of thermosensitive mucoadhesive gel incorporated lipid microspheres of donepezil for enhanced nose-to-brain delivery.","authors":"Rachmatya W Tuna, Nurafni Annisa Achmad, Irfan Kurniawan, Khairiyah, Muh Bisfain Asaf, Zulfiayu Sapiun, Achmad Himawan, Juan Dominguez-Robles, Muhammad Aswad, Andi Dian Permana","doi":"10.1080/09205063.2025.2492455","DOIUrl":"https://doi.org/10.1080/09205063.2025.2492455","url":null,"abstract":"<p><p>Alzheimer's disease (ALZ) is a chronic disease that affects the brain neurons leading to dementia. Donepezil (DPZ), a first-line treatment for ALZ is a potent symptomatic therapeutic agent. However, the oral and transdermal route represents non-targeted delivery, causing various adverse effects. This study presents the successful incorporation of a DPZ-loaded lipid microsphere (DPZ-LM) system into a thermosensitive-mucoadhesive gel (TMG), thereby enhancing the delivery of DPZ through the nose-to-brain route. To optimize the formulations, several evaluations were conducted, resulting in an optimized formulation of LM using Compritol^® exhibited particle size of 8.75 µm, 98.44% of DPZ entrapped, and 93.40% of DPZ loaded in the system with a sustained release manner in the <i>in vitro</i> studies. The TMG-DPZ-LM was prepared using Pluronic^® F127 and F68, as the gelling agents, with the addition of sodium alginate, as the mucoadhesive polymer. Following incorporation into TMG-DPZ-LM, the system exhibited excellent physicochemical properties and effective nasal delivery in <i>ex vivo</i> permeation has found that 88.58 ± 12.53 µg/cm² and retention studies with a mean concentration of 0.0077 mg of retention DPZ in porcine nasal mucosa. The <i>in vivo</i> pharmacokinetic studies demonstrated that the administration of TMG-DPZ-LM <i>via</i> the nose-to-brain route resulted in a significant (<i>p</i> < 0.05) increase in the C_max, with 207.24 ± 5.16 µg/cm³ of DPZ in the brain that exhibited a significantly different profile compared to the other route and formulation. The TMG-DPZ-LM system that was developed in this study was considered to have improved its efficacy in the treatment of ALZ.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-28"},"PeriodicalIF":3.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characterization of advancing wound care with PVP/QCS/DEX hydrogels: a multifunctional wound dressing composite: <i>in vitro</i> and <i>in vivo</i> assay.","authors":"Masoumeh Hatami, Mohammad Taghi Khorasani, Ebrahim Ahmadi, Sonia Mohamadnia","doi":"10.1080/09205063.2025.2487655","DOIUrl":"https://doi.org/10.1080/09205063.2025.2487655","url":null,"abstract":"<p><p>Although the skin has a high healing capacity, severe skin wounds often require external interventions to heal properly. Tissue-engineered wound dressings have indeed gained significant attention among various treatment strategies for wound healing. This study focuses on the integration of polyvinyl pyrrolidone (PVP), quaternized chitosan (QCS), and dextran (DEX) to prepare a ternary composite (PVP/QCS/DEX) as a wound dressing hydrogels with varying concentration of PVP and DEX. A variety of analytical methods, including infrared spectroscopy (FTIR), scanning electron microscopy (SEM), contact angle, and water vapor transmission rate (WVTR) were employed to assess the characteristics of the samples. The uniform and interconnected porous structure of the samples was confirmed by the SEM results. All the samples showed high porosity and water vapor transition rate, demonstrating their ability to provide a suitable moist environment and efficient exudate handling for wound healing. The antibacterial test conducted on hydrogels demonstrated the antibacterial activity of hydrogels and drug-loaded hydrogel samples including <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. The <i>in vitro</i> cytotoxicity evaluation using the MTT assay demonstrated that the developed PVP/QCS/DEX hydrogels exhibit satisfactory cytocompatibility and promote cell viability. The results of the scratch assay indicated that the samples had promoted the cell migration and would improve and accelerate wound healing process. The <i>in vivo</i> healing tests conducted by the drug-loaded hydrogel sample revealed a promising healing performance. Therefore, based on the favorable performance observed throughout the various tests and analysis, the as-prepared PVP/QCS/DEX hydrogels show significant promise in the field of wound dressings.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-31"},"PeriodicalIF":3.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tamarind seed polymer-based formulations: advances and applications in biomedical science.","authors":"Ramya Sri, Tanmoy Ghosh, Basavaraj B V, Lakshmi Priya P","doi":"10.1080/09205063.2025.2491604","DOIUrl":"https://doi.org/10.1080/09205063.2025.2491604","url":null,"abstract":"<p><p>Tamarind seed polymer has garnered significant attention in biomedical science due to its exceptional properties, like biocompatibility, biodegradability, and adaptability for drug delivery. Derived from tamarind seeds, tamarind gum, a natural polysaccharide, shows great potential as a gelling agent for controlled drug release. Its versatility makes it suitable for delivering both water-soluble and water-insoluble drugs. This opens up exciting opportunities in areas such as oral drug delivery, wound healing, tissue regeneration, anti-inflammatory treatments, and ophthalmic drug delivery. Tamarind seed-based formulations have the remarkable ability to modify drug release rates, enhance drug stability, and improve bioavailability, making them a promising option for advancing healthcare. This review delves into the advancements and ongoing research surrounding tamarind seed polymer systems, highlighting their diverse applications and untapped potential in the biomedical and pharmaceutical fields.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D bioprinted alginate/gelatin hydrogel: concentration modulated properties toward scar-minimized wound healing.","authors":"Tian Jiao, Chaofan Sun, Zhuo Wang, Guiquan Han, Haoping Wang","doi":"10.1080/09205063.2025.2491609","DOIUrl":"https://doi.org/10.1080/09205063.2025.2491609","url":null,"abstract":"<p><p>The critical shortage of transplantable skin remains a leading cause of mortality in patients with severe skin injuries, driving the demand for advanced 3D-bioprinted constructs. While hydrogel-based bioinks are pivotal for skin tissue engineering, existing systems often fail to simultaneously address biomechanical compatibility, scar suppression, and cell viability. Here, we propose a rationally designed sodium alginate/gelatin (SA/Gel) hydrogel platform through composition-property-performance correlation analysis. Systematic characterization revealed that increasing gelatin content (8-12 wt%) enhanced viscosity (by 2.5-fold), compressive modulus (25.6 ± 2.7 kPa to 37.9 ± 3.5 kPa), tensile fracture elongation (57.9 ± 4.2% to 92.1 ± 1.3%), and print fidelity, while reducing degradation ratio (62.8 ± 2.9% to 26.4 ± 2.4% at day 14) and pore size (128.5 ± 16.6 μm to 79.4 ± 19.7 μm). The optimized A4G10 formulation exhibited synergistic advantages: (1) dynamic swelling (36.3 ± 0.8%) balanced nutrient permeation with structural stability; (2) tunable degradation (47.2% at day 14) matched neo-tissue formation; (3) anisotropic mechanical properties (compressive modulus 32.2 ± 4.1 kPa, tensile modulus 31.7 ± 3.9 kPa) mimicked native skin mechanics; (4) sub-100 μm porous architecture (102.9 ± 12.4 μm) effectively suppressed fibroblast over--proliferation. Remarkably, the SA/Gel scaffolds maintained 98% cell viability (Live/Dead assay) <i>in vitro</i>, while suppressing fibrotic tissue formation and facilitating angiogenesis <i>in vivo</i>. This multi-functional SA/Gel system demonstrates unprecedented potential as a scar--inhibiting bioink for clinical-grade skin regeneration.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-22"},"PeriodicalIF":3.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional hydrogels for accelerated wound healing: advances in conductive hydrogels and self-powered electrical stimulation.","authors":"Junyi Zhu, Zesheng Chen, Binghai Dong","doi":"10.1080/09205063.2025.2486858","DOIUrl":"https://doi.org/10.1080/09205063.2025.2486858","url":null,"abstract":"<p><p>Compared to traditional dressings, hydrogel dressings not only protect the wound surface and prevent bacterial infection but also possess excellent moisturizing properties, which can provide an optimal moist environment for wound healing, and exhibit good biocompatibility, making them considered the best wound treatment materials. This review focuses on the research status and application progress of various functional hydrogel dressings, such as hemostatic, antimicrobial, anti-inflammatory, antioxidant, and conductive hydrogels. It proposes the combination of conductive hydrogels with flexible solar cells to form self-powered devices. Compared to traditional externally powered devices, this approach can reduce carbon footprints by utilizing clean energy, aligning with carbon neutrality policy requirements. Additionally, it eliminates the need for frequent battery replacement or power connections, effectively saving labor and operational costs. Self-powered devices can convert solar energy into electrical energy, which is conducted to the wound site through hydrogels, generating continuous electrical stimulation (ES). This electrical stimulation guides the directional migration of keratinocytes and fibroblasts toward the center of the wound; activates the MAPK/ERK signaling pathway to accelerate the cell cycle process, and upregulates the expression of vascular endothelial growth factor, thereby inducing endothelial cell proliferation and lumen formation. These multiple mechanisms work synergistically to promote wound healing. Finally, the review provides an outlook on the emergence and applications of multifunctional hydrogels and stimuli-responsive hydrogels, highlighting common challenges in the future development of hydrogels, such as weak mechanical strength and poor long-term stability, as well as feasible solutions to these issues.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-ionizing (UV and MW)-assisted synthesis of polymeric hydrogels for advanced tissue engineering applications.","authors":"Anca Scărișoreanu, Maria Demeter, Ion Călina, Muhammad Asim Raza","doi":"10.1080/09205063.2025.2486866","DOIUrl":"https://doi.org/10.1080/09205063.2025.2486866","url":null,"abstract":"<p><p>Significant efforts are underway to develop next-generation biomaterials through clean processes, accelerating the transition from innovative materials to tissue engineering (TE) applications and providing new alternatives for complex tissue repair. A crucial aspect of TE is selecting appropriate matrix materials with optimal physical and bioactive properties for scaffold development. For this purpose, polymers have repeatedly proven effective in creating suitable structures for successful TE applications. In this respect, ultraviolet (UV) and microwave (MW)-assisted synthesis has emerged as promising approaches in TE, offering improved material properties and reduced processing times. UV-assisted synthesis provides advantages, such as rapid gelation, customizable characteristics, and compatibility with various biological materials. MW-assisted synthesis accelerates chemical reactions through localized heating, elimination of side reaction products, and enhanced molecular interactions, enabling rapid fabrication of biocompatible materials such as hydrogels, ceramics, and composites. This review explores the effect of UV and MW-assisted synthesis on polymeric hydrogels for advancing novel materials in TE. The paper outlines the advantages of each technique, including technical specifications of reaction synthesis and recent advancements in UV and MW equipment developments. Additionally, each technique is carefully stated, highlighting hydrogels with enhanced biocompatibility through biological testing, and enhanced efficacy in regenerating soft and hard tissues.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-33"},"PeriodicalIF":3.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carboxymethyl bacterial cellulose electrospun nanofibers loaded with zinc oxide nanoparticles and polyhexamethylene biguanide for wound healing promotion.","authors":"Neda Molaee, Shohreh Fahimirad, Ali Ganji, Hamid Abtahi","doi":"10.1080/09205063.2025.2490079","DOIUrl":"https://doi.org/10.1080/09205063.2025.2490079","url":null,"abstract":"<p><p>This study explores the development of a novel wound dressing incorporating bacterial cellulose (BC) produced by <i>Acetobacter xylinum</i>, which was carboxymethylated to enhance its biomedical applicability. Zinc oxide nanoparticles (ZnONPs) were biosynthesized using a green method with <i>Quercus infectoria</i> gall extracts (QIG). The composite dressing, composed of BC and polyurethane (PU) nanofibers, was further functionalized with ZnONPs and polyhexamethylene biguanide (PHMB) to provide enhanced antibacterial and wound healing properties. The PU/BC/ZnONPs/PHMB nanofiber mat exhibited strong antibacterial activity against Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), with inhibition zones of 28 and 29 mm for PU/BC/ZnONPs and PU/BC/ZnONPs/PHMB, respectively, surpassing the 12 mm inhibition zone of the Cefoxitin control. The nanofibers had an optimal mean diameter of 71.12 nm, ensuring a high surface area for cell attachment. Mechanical tests confirmed excellent tensile strength and flexibility, while an optimized water vapor transmission rate (∼2000-3000 g/m²/day) facilitated a moist wound environment for enhanced healing. L929 fibroblast studies demonstrated high cell viability (∼95-98%) and enhanced migration, confirming the nanofiber mat's biocompatibility. <i>In vivo</i> wound healing tests showed that PU/BC/ZnONPs/PHMB significantly accelerated wound closure, achieving 90-100% healing by day 10, outperforming PU and PU/BC groups. Bacterial counts were significantly reduced, with complete bacterial inhibition observed by day 5. In conclusion, the PU/BC/ZnONPs/PHMB nanofiber dressing demonstrated superior antibacterial activity, mechanical strength, moisture regulation, and wound healing potential, making it a promising candidate for advanced clinical wound management.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-36"},"PeriodicalIF":3.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}