Journal of Biomaterials Science, Polymer Edition最新文献_第10页

A systematic review on hyaluronic acid coated nanoparticles: recent strategy in breast cancer management. 透明质酸涂层纳米粒子系统综述：乳腺癌治疗的最新策略

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-04-01 Epub Date: 2024-10-21 DOI: 10.1080/09205063.2024.2416293

Seema S Rathore, J Josephine Leno Jenita, Manjula Dotherabandi

{"title":"A systematic review on hyaluronic acid coated nanoparticles: recent strategy in breast cancer management.","authors":"Seema S Rathore, J Josephine Leno Jenita, Manjula Dotherabandi","doi":"10.1080/09205063.2024.2416293","DOIUrl":"10.1080/09205063.2024.2416293","url":null,"abstract":"Hyaluronic acid, a non-sulphated glycosaminoglycan has attracted its usage in the management of breast cancer. Drug-loaded nanoparticles with hyaluronic acid surface modifications show potential as a promising method for targeting and delivering drugs to the tumor site. The aim of this study was to conduct a systematic review of articles and assess the impact of hyaluronic acid coated nanoparticles on breast cancer. The various database were used for this comprehensive review. The inclusion and exclusion criteria were selected according to the PRISMA guidelines. Studies associated with characterization, in vitro, and in vivo studies were collected and subjected for further analysis. According to the inclusion criteria, 41 literature were selected for analysis. From all the studies, it was observed that the nanoparticles coated with hyaluronic acid produced better particle size, shape, zeta potential, increased in vitro cytotoxicity, cellular uptake, cell apoptosis, and anti-tumor effect in vivo. Research has shown that hyaluronic acid exhibits a higher affinity for CD44 receptors, resulting in enhanced targeted nanoparticle activity on cancer cells while sparing normal cells.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"605-646"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review on using injectable chitosan microgels for osteochondral tissue repair. 关于使用可注射壳聚糖微凝胶修复骨软骨组织的全面综述。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-04-01 Epub Date: 2024-10-26 DOI: 10.1080/09205063.2024.2419715

Sarah Salehi

{"title":"A comprehensive review on using injectable chitosan microgels for osteochondral tissue repair.","authors":"Sarah Salehi","doi":"10.1080/09205063.2024.2419715","DOIUrl":"10.1080/09205063.2024.2419715","url":null,"abstract":"Restoring cartilage to healthy state is challenging due to low cell density and hence low regenerative capacity. The current platforms are not compatible with clinical translation and require dedicated handling of trained personnel. However, by engineering and implanting cell microaggregates in higher concentrations, efficient formation of new cartilage can be achieved, even in the absence of exogenous growth factors. Therefore, one-step surgeries are preferable for novel treatments and we need cell laden microgels allowing the formation of microaggregaets in vivo. Injectability is a key parameter for in situ forming the shape and minimally invasive clinical applications. Hydrogels as bioinks can restore damaged tissues to their primary shape. Chitosan is a polysaccharide derived from chitin with abundant usage in tissue engineering. This review highlights the use of chitosan as an injectable hydrogel for osteochondral defects. Several studies focused on encapsulating mesenchymal stem cells within chitosan hydrogels have been categorized and incorporating microfluidic devices has been identified in the forefront to form microgels. Additionally, the printability is another convenience of chitosan for using in 3D printing for cartilage tissue engineering which is described in this review.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"647-662"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-04-01 Epub Date: 2024-12-29 DOI: 10.1080/09205063.2024.2447675

引用次数: 0

Lecithin-based mixed polymeric micelles for activity improvement of curcumin against Staphylococcus aureus. 基于卵磷脂的混合聚合物胶束用于提高姜黄素对金黄色葡萄球菌的活性。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-04-01 Epub Date: 2024-10-26 DOI: 10.1080/09205063.2024.2421089

Yunjing Jia, Yuli Li, Mingzhu Wang, Fuyou Wang, Qingmin Liu, Zhimei Song

{"title":"Lecithin-based mixed polymeric micelles for activity improvement of curcumin against Staphylococcus aureus.","authors":"Yunjing Jia, Yuli Li, Mingzhu Wang, Fuyou Wang, Qingmin Liu, Zhimei Song","doi":"10.1080/09205063.2024.2421089","DOIUrl":"10.1080/09205063.2024.2421089","url":null,"abstract":"Considering cellular uptake promotion of lecithin and high expression of phospholipase in S. aureus, we designed curcumin (Cur)-loaded soy lecithin-based mPEG-PVL copolymer micelles (MPPC). The effect of soy lecithin on the anti-S. aureus activity of the formulation was studied with cur-loaded mPEG-PVL micelles (MPC without soy lecithin) as control. It was found that MPPC enhanced the water-solubility of Cur, and showed slow and sustained release behavior of Cur. Although MPPC had the same anti-S. aureus activity as Cur, its activity was significantly higher than MPC due to the cellular uptake promotion of soybean lecithin. It was noted that MPPC had good inhibition or destruction effect on biofilm, significant cell membrane damage, strong inhibition effect on protease or lipase production, and obvious induction effect on ROS expression when compared with Cur and MPC. So, the introduction of soy lecithin could improve the antibacterial activity of Cur. The lecithin-based micelles would offer potential to deliver antibacterial drugs for improved therapeutic action.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"587-604"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical properties and biocompatibility characterization of 3D printed collagen type II/silk fibroin/hyaluronic acid scaffold. 三维打印 II 型胶原蛋白/丝纤维素/透明质酸支架的力学性能和生物相容性表征。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-04-01 Epub Date: 2024-10-10 DOI: 10.1080/09205063.2024.2411797

Lilan Gao, Yali Li, Gang Liu, Xianglong Lin, Yansong Tan, Jie Liu, Ruixin Li, Chunqiu Zhang

{"title":"Mechanical properties and biocompatibility characterization of 3D printed collagen type II/silk fibroin/hyaluronic acid scaffold.","authors":"Lilan Gao, Yali Li, Gang Liu, Xianglong Lin, Yansong Tan, Jie Liu, Ruixin Li, Chunqiu Zhang","doi":"10.1080/09205063.2024.2411797","DOIUrl":"10.1080/09205063.2024.2411797","url":null,"abstract":"Damage to articular cartilage is irreversible and its ability to heal is minimal. The development of articular cartilage in tissue engineering requires suitable biomaterials as scaffolds that provide a 3D natural microenvironment for the development and growth of articular cartilage. This study aims to investigate the applicability of a 3D printed CSH (collagen type II/silk fibroin/hyaluronic acid) scaffold for constructing cartilage tissue engineering. The results showed that the composite scaffold had a three-dimensional porous network structure with uniform pore sizes and good connectivity. The hydrophilicity of the composite scaffold was 1071.7 ± 131.6%, the porosity was 85.12 ± 1.6%, and the compressive elastic modulus was 36.54 ± 2.28 kPa. The creep and stress relaxation constitutive models were also established, which could well describe the visco-elastic mechanical behavior of the scaffold. The biocompatibility experiments showed that the CSH scaffold was very suitable for the adhesion and proliferation of chondrocytes. Under dynamic compressive loading conditions, it was able to promote cell adhesion and proliferation on the scaffold surface. The 3D printed CSH scaffold is expected to be ideal for promoting articular cartilage regeneration.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"564-586"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ROS-responsive nanomicelles encapsulating celastrol ameliorate pressure overload-induced cardiac hypertrophy by regulating the NF-κB signaling pathway. ROS响应性纳米细胞包裹的仙鹤草醇通过调节NF-κB信号通路，改善压力过载诱导的心肌肥大。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-04-01 Epub Date: 2024-10-14 DOI: 10.1080/09205063.2024.2411095

Shanjiang Chen, Jianjian Yang, Fuli Liu

{"title":"ROS-responsive nanomicelles encapsulating celastrol ameliorate pressure overload-induced cardiac hypertrophy by regulating the NF-κB signaling pathway.","authors":"Shanjiang Chen, Jianjian Yang, Fuli Liu","doi":"10.1080/09205063.2024.2411095","DOIUrl":"10.1080/09205063.2024.2411095","url":null,"abstract":"Celastrol (CEL) belongs to the group of non-steroidal immunosuppressants with the potential to improve cardiac hypertrophy (CH). However, the poor biocompatibility and low bioavailability of CEL limit its in vivo application. This study was aimed to develop a targeted drug delivery system that can efficiently and safely deliver CEL to target tissues, providing a research basis for the application of CEL in CH therapy. A novel ROS-sensitive drug-loaded nanomicelle, dodecanoic acid (DA)-phenylboronic acid pinacol ester-dextran polymer encapsulating CEL (DBD@CEL), was synthesized using chemical synthesis. Then, the morphology, particle size, drug-loaded content, and ROS-responsive release behavior of DBD@CEL were studied. Pharmacokinetics and biocompatibility were evaluated using healthy mice. Finally, the ability and mechanism of DBD@CEL in improving CH in vivo were investigated using a mouse CH model. DBD@CEL was successfully prepared with a drug loading of 18.9%. It exhibited excellent stability with an average particle size of 110.0 ± 1.7 nm. Within 48 h, DBD@CEL released only 19.4% in the absence of H2O2, while in the presence of 1 mM H2O2, the release rate increased to 71.5%. Biocompatibility studies indicated that DBD@CEL did not cause blood cell hemolysis, had no impact on normal organs, and did not result in abnormal blood biochemical indicators, demonstrating excellent biocompatibility. In vivo studies revealed that DBD@CEL regulated the activation of NF-κB signaling, inhibits pyroptosis and oxidative stress, and thereby ameliorates CH. The ROS-responsive DBD@CEL nanodrug delivery system enhances the therapeutic activity of CEL for CH, providing a promising drug delivery system for the clinical treatment of CH.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"545-563"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation, optimization, and evaluation of ligand-tethered atovaquone-proguanil-loaded nanoparticles for malaria treatment. 用于疟疾治疗的配体系留阿托伐醌-丙二胍负载纳米颗粒的制备、优化和评估。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-04-01 Epub Date: 2024-11-10 DOI: 10.1080/09205063.2024.2422704

Anasuya Patil, Gurinderdeep Singh, Rajendra Dnyandeo Dighe, Dhruv Dev, Bhaveshkumar A Patel, Samatha Rudrangi, Gaurav Tiwari

{"title":"Preparation, optimization, and evaluation of ligand-tethered atovaquone-proguanil-loaded nanoparticles for malaria treatment.","authors":"Anasuya Patil, Gurinderdeep Singh, Rajendra Dnyandeo Dighe, Dhruv Dev, Bhaveshkumar A Patel, Samatha Rudrangi, Gaurav Tiwari","doi":"10.1080/09205063.2024.2422704","DOIUrl":"10.1080/09205063.2024.2422704","url":null,"abstract":"This work focused on improving antimalarial therapy through the development and characterization of Atovaquone-Proguanil-loaded nanoparticles employing a 32 factorial design. The nanoparticles were prepared from combinations of Poly(lactic-co-glycolic acid) (PLGA) and Eudragit L100 polymers and different concentrations of PVA (polyvinyl alcohol). Based on the results obtained the formulations were characterized for the particle size, zeta potential, encapsulation efficiency, and percent drug release. Among the nine formulations, F5 proved to be the most favorable in the biophysical parameters with a particle size of 176.3 nm, a zeta potential of -33.5 mV, and an encapsulation efficiency of 86% was found in the present investigation. Experimental dissolution profile analysis indicated that F5 had a slow and controlled-release profile where approximately 92.5%. Besides, cytotoxicity studies employing MTT, LDH (lactate dehydrogenase), and Trypan blue reduction test also supported the biocompatibility of nanoparticles and F5 had the highest cell viability (96%) with the least LDH release of 4%. In stability studies conducted for six months, F5 was found to remain stable regarding physicochemical characteristics and drug release profile at different temperature conditions such as room temperature, 4 °C, and 45 °C. The use of folic acid-functionalized nanoparticles is more effective, according to parasitemia, survival rate, and weight loss in mice treated with the nanoparticles. This is because functionalized nanoparticles could be used to enhance anti-malarial therapies.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"711-742"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and improvements in multi-layer mucosa-adhesive films for oral diseases treatment and prognosis. 用于口腔疾病治疗和预后的多层粘膜粘合薄膜的挑战与改进。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-04-01 Epub Date: 2024-11-07 DOI: 10.1080/09205063.2024.2422213

Ruohan Zhai, Yaxian Liang, Ruijianghan Shi, Huixu Xie

{"title":"Challenges and improvements in multi-layer mucosa-adhesive films for oral diseases treatment and prognosis.","authors":"Ruohan Zhai, Yaxian Liang, Ruijianghan Shi, Huixu Xie","doi":"10.1080/09205063.2024.2422213","DOIUrl":"10.1080/09205063.2024.2422213","url":null,"abstract":"Due to the complexity of oral physiology and pathology, the treatment of oral diseases faces multiple and complex clinical requirements. Mucosa-adhesive films (MAFs) with a single layer have demonstrated considerable potential in delivering therapeutic bioactive ingredients directly to the site of oral diseases. However, their functions are often hindered by certain factors such as limited loading capacity, poor site specificity, and sensitivity to mechanical stimuli. To overcome these limitations, the development of multi-layer MAFs has become a focal point for recent research. This involves the improvement of construction methods for multi-layer MAFs to minimize potential health risks from residual solvents, and conducting comprehensive in vivo studies to evaluate their safety and therapeutic efficacy more accurately, thus paving the way for their commercialization. Additionally, the exploration of multi-layer MAFs as personalized drug delivery systems could further broaden their application prospect. Precisely, multi-layer MAFs compensate for the shortcomings of current therapeutic strategies for oral diseases to a great extent, indicating a promising future in the market.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"663-687"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial collagen-guar gum hydrogels with zeolitic imidazolate framework-67 (ZIF-67): an innovative platform for advanced wound healing. 抗菌胶原-瓜尔胶水凝胶与沸石咪唑酸框架-67 (ZIF-67)：一个创新的平台，先进的伤口愈合。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-04-01 DOI: 10.1080/09205063.2025.2486859

Danna V Hernandez-Urquizo, Jesús A Claudio Rizo, Denis A Cabrera-Munguía, Martín Caldera-Villalobos, Maria I León-Campos, Francisco J Enríquez-Medrano, Luis Ernesto Elizalde-Herrera

{"title":"Antibacterial collagen-guar gum hydrogels with zeolitic imidazolate framework-67 (ZIF-67): an innovative platform for advanced wound healing.","authors":"Danna V Hernandez-Urquizo, Jesús A Claudio Rizo, Denis A Cabrera-Munguía, Martín Caldera-Villalobos, Maria I León-Campos, Francisco J Enríquez-Medrano, Luis Ernesto Elizalde-Herrera","doi":"10.1080/09205063.2025.2486859","DOIUrl":"https://doi.org/10.1080/09205063.2025.2486859","url":null,"abstract":"The current challenge in developing wound healing dressings lies in achieving antibacterial effects while avoiding cytotoxicity to cells that are crucial for the healing process. Addressing this challenge, Zeolitic Imidazolate Framework-67 (ZIF-67), a cobalt-containing metal-organic framework (MOF), has emerged as a promising additive due to cobalt's broad-spectrum antimicrobial effects. This study developed semi-interpenetrating polymer network (semi-IPN) hydrogels by incorporating 1-3 wt.% ZIF-67 into collagen-guar gum matrices, resulting in biocomposites with tunable structural and functional properties. These biocomposites exhibit a fibrillar-granular morphology, uniform cobalt ion distribution on a semi-crystalline surface, and strong antibacterial activity against Escherichia coli (E. coli). At 3 wt.%, ZIF-67 accelerates gelation, strengthens crosslinking interactions, and enhances the storage modulus, thermal stability, and hydrolytic resistance of the hydrogels. Furthermore, biocomposites with 1 wt.% ZIF-67 also function as in-situ curcumin delivery systems, offering controlled release under physiological conditions and significant biodegradation in the presence of collagenase. In vitro tests demonstrate that the chemical composition of these hydrogels, regardless of ZIF-67 content, effectively supports monocyte and fibroblast metabolic activity, promotes cell proliferation, and increases interleukin-10 (IL-10) secretion by human monocytes. Additionally, the absence of hemolytic effects in human blood further underscores the safety and suitability of these hydrogel biocomposites for advanced wound treatment applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-26"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospun zinc oxide nanoscaffolds: a targeted and selective anticancer approach. 电纺氧化锌纳米支架：一种靶向性和选择性抗癌方法。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-04-01 Epub Date: 2024-11-07 DOI: 10.1080/09205063.2024.2422698

Zeinab A S Said, Haitham S Mohammed, Sara Ibrahim, Hanan H Amer

{"title":"Electrospun zinc oxide nanoscaffolds: a targeted and selective anticancer approach.","authors":"Zeinab A S Said, Haitham S Mohammed, Sara Ibrahim, Hanan H Amer","doi":"10.1080/09205063.2024.2422698","DOIUrl":"10.1080/09205063.2024.2422698","url":null,"abstract":"This study aims to prepare, characterize, and evaluate zinc oxide nanoscaffolds (ZnO NSs) as a potential anticancer drug that selectively targets malignant cells while remaining non-toxic to normal cells. Electrospun NSs were fabricated and loaded with varying concentrations of ZnO nanoparticles (NPs). The uniform morphology of the fabricated samples was confirmed through Field Emission Scanning Electron Microscope (FESEM) imaging. Elemental composition was investigated using Energy Dispersive X-ray spectroscopy (EDX), Fourier Transform Infrared (FTIR), and X-ray diffraction (XRD) analyses. Biocompatibility and cytotoxicity were assessed using the (3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay) (MTT) assay and flow cytometry. The water uptake and degradation properties of the electrospun NSs were also examined. Furthermore, a cumulative release profile was generated to assess the release behavior of ZnO NSs. The prepared ZnO NSs demonstrated negligible toxicity toward normal human dermal cells. Conversely, the four used concentrations of ZnO NSs displayed substantial cytotoxicity and induced apoptosis in various cancer cell lines. The observed effects were concentration-dependent. Notably, ZnO NSs 8% exhibited the most significant reduction in cell viability against the MCF7 cell line. The findings from this study indicate the potential of ZnO NSs as an effective anticancer agent, with the ZnO NSs 8% demonstrating the most pronounced impact. This research introduces a novel application of electrospun zinc oxide nanoscaffolds, demonstrating their capacity for selective anticancer activity, particularly against breast carcinoma, while preserving normal cell viability. The study presents a significant advancement in the use of nanomaterial for targeted cancer therapy.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"689-710"},"PeriodicalIF":3.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0