Journal of Biomaterials Science, Polymer Edition最新文献_第10页

A new path in bone tissue engineering: polymer-based 3D-printed magnetic scaffolds (a comprehensive review of in vitro and in vivo studies). 骨组织工程的新途径：基于聚合物的3d打印磁性支架（体外和体内研究的综合综述）。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-23 DOI: 10.1080/09205063.2024.2444077

Atiyeh Sadat Safavi, Saeed Karbasi

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Development, in vitro and in vivo evaluation of film forming solutions for transdermal drug delivery of Zaltoprofen. 扎尔托洛芬经皮给药成膜溶液的研制、体外和体内评价。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-23 DOI: 10.1080/09205063.2024.2443332

Prajila Alayadan, Avichal Kumar, Sanjana S Prakash, Babiker Bashir, V Bhagya, S Narasimha Murthy, H N Shivakumar

{"title":"Development, in vitro and in vivo evaluation of film forming solutions for transdermal drug delivery of Zaltoprofen.","authors":"Prajila Alayadan, Avichal Kumar, Sanjana S Prakash, Babiker Bashir, V Bhagya, S Narasimha Murthy, H N Shivakumar","doi":"10.1080/09205063.2024.2443332","DOIUrl":"https://doi.org/10.1080/09205063.2024.2443332","url":null,"abstract":"Zaltoprofen (ZAL) is a non-steroidal anti-inflammatory drug (NSAID) with a short half-life (∼2.8 h) due to extensive first pass metabolism. In this context, 16 different polymeric film forming solutions (PFFS) of ZAL were developed using different grades of Eudragits, Polyvinylpyrrolidones, Kollicoat MAE 100 P and Hydroxypropyl cellulose as film formers, and polyethylene glycol 400 as a plasticizer in equal parts of ethanol and isopropyl alcohol used as solvents. Of these solutions, F13 composed of Kollicoat MAE 100 P emerged as an optimal PFFS as it quickly formed a saturated film (10.25 ± 0.75 min) that displayed low drying time (3.00 ± 0.46 min), and high in vitro adhesion (2.67 ± 0.58). Ex vivo permeation studies conducted in Franz diffusion cell across porcine skin indicated that F13 displayed significantly higher (p < 0.001) steady state flux (8.64 ± 1.72 µg.cm-2.h-1), shorter lag time (∼3 h) and better skin content (2.55 ± 0.62 µg/mg) compared to other PFFS. Fourier Transform Infrared Spectroscopy (FT-IR) proved the chemical integrity of ZAL in polymeric film formed from F13, while Differential scanning calorimetry (DSC) and X-ray Diffractometry (XRD) proved the \"anti-recrystallization potential\" of PFFS. Anti-inflammatory studies in rats indicated that F13 significantly inhibited (ANOVA, p < 0.001) carrageenan induced paw edema for nearly 12 h compared to topical diclofenac used as standard. In addition, significantly elevated (ANOVA, p < 0.001) analgesic effect was noted in the hot plate test in rats treated with F13 compared to the standard for 12 h proving the superior efficacy of F13. Thus, PFFS by virtue of \"in situ evaporative metamorphosis\" induced supersaturation can be an attractive platform to deliver ZAL transdermally.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Overview of chitin dissolution, hydrogel formation and its biomedical applications. 几丁质溶解、水凝胶形成及其生物医学应用综述。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-20 DOI: 10.1080/09205063.2024.2442181

Kavipriya Murugaiyan, Vishnu Priya Murali, Hiroshi Tamura, Tetsuya Furuike, Jayakumar Rangasamy

{"title":"Overview of chitin dissolution, hydrogel formation and its biomedical applications.","authors":"Kavipriya Murugaiyan, Vishnu Priya Murali, Hiroshi Tamura, Tetsuya Furuike, Jayakumar Rangasamy","doi":"10.1080/09205063.2024.2442181","DOIUrl":"https://doi.org/10.1080/09205063.2024.2442181","url":null,"abstract":"Chitin hydrogel and hydrogel-based products are some of the frequently reported biomaterials for biomedical applications. Yet there is a void in understanding chitin's dissolution mechanism and its most suitable solvent system(s). Chitin is a natural polysaccharide polymer which can be dissolved in solvents such as calcium chloride- methanol, sodium hydroxide/urea (NaOH/urea), lithium chloride diacetamide (LiCl/DMAc), ionic liquids and deep eutectic solvents. Among the alkali/urea dissolution systems such as NaOH/urea, KOH/urea, LiOH/urea for dissolution of chitin we will be focussing on NaOH-based system here for ease of comparison with the other systems. Chitin has been used for decades in the biomedical field; however, new solvent systems are still being explored even to this day to identify the most suitable chemical(s) for dissolving it. Chitin, due to its biocompatibility, allows us to use it for multifaceted purposes. Hence, it is important to consolidate the available studies for better understanding about the most sought-after biomaterial. This overview deeply delves into the mechanism of action of the existing solvent systems and highlights its merits and demerits. It discusses the rheological properties of the chitin gel from different solvent systems and puts forth the current biomedical applications of chitin gel in areas such as tissue engineering, drug delivery, biosensing, hemostasis and wound healing. It also outlines recent advances and highlights the potential gaps which need to be addressed in future studies.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Characterization, antimicrobial and antioxidant activity of bee bread encapsulated with chitosan nanoparticle. 壳聚糖纳米颗粒包封蜜蜂面包的表征及其抗菌抗氧化活性。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-20 DOI: 10.1080/09205063.2024.2441032

Stanley Nnamdi Ogoh, Erkay Özgör

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Exploration of mechanical properties and osseointegration capacity of porous PEEK composites containing strontium and alendronate under 3D printing: an emerging bone implant. 含锶和阿仑膦酸的多孔 PEEK 复合材料在 3D 打印下的机械性能和骨结合能力探索：一种新兴的骨植入物。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-15 DOI: 10.1080/09205063.2024.2438498

Binwei Qin, Baifang Zeng, Danwei Shen, Jiayan Deng, Haigang Hu, Xiangyu Wang, Hong Li, Taicong Yang, Lian Xu, Chao Wu

{"title":"Exploration of mechanical properties and osseointegration capacity of porous PEEK composites containing strontium and alendronate under 3D printing: an emerging bone implant.","authors":"Binwei Qin, Baifang Zeng, Danwei Shen, Jiayan Deng, Haigang Hu, Xiangyu Wang, Hong Li, Taicong Yang, Lian Xu, Chao Wu","doi":"10.1080/09205063.2024.2438498","DOIUrl":"https://doi.org/10.1080/09205063.2024.2438498","url":null,"abstract":"The aim of this study was to evaluate the biomechanical and osseointegrative properties of 3D printed porous PEEK materials loaded with strontium (Sr) and alendronate (ALN), which prepared porous cylindrical material by a fused deposition molding process, coated with Sr and ALN by hydrothermal reaction and dopamine assistance. According to the different coating materials, it could be divided into the PEEK group, PEEK-ALN group, PEEK-Sr group and PEEK-ALN-Sr group. After completing the mechanical analyses, the materials were implanted into the femoral condyles of New Zealand rabbits and the osteogenic capacity of the bracket materials was assessed by Micro-CT scanning, histology and fluorescence staining. The results showed that ALN and Sr were successfully loaded onto the surface of the material, and the elastic modulus and porosity of the material were not changed significantly after loading. The Micro-CT revealed that the PEEK-ALN-Sr group exhibited differences in bone volume/total Volume (BV/TV), trabecular spacing (TB.Sp),trabecular thickness (TB.Th)and trabeculae number (TB.N) in comparison to the PEEK group and PEEK-ALN group. And more new bone tissues could be observed in the PEEK-ALN-Sr group under 3D reconstruction of the bone proliferation model, toluidine blue and fluorescence staining. Thus, we can conclude that the 3D printed porous PEEK material has stable pore size and porosity, which has an ideal structure for bone growth. The PEEK- ALN-Sr composite material can be used as an emerging bone implant due to its excellent elastic modulus and osseointegration ability and provides a clinically viable treatment for patients with bone defects.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-16"},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Alkaline etching assisted polydopamine coating for enhanced cell-material interactions on 3D printed polylactic acid scaffolds. 碱性蚀刻辅助聚多巴胺涂层可增强三维打印聚乳酸支架上细胞与材料的相互作用。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-15 DOI: 10.1080/09205063.2024.2436691

Athira Murali, Ramesh Parameswaran

{"title":"Alkaline etching assisted polydopamine coating for enhanced cell-material interactions on 3D printed polylactic acid scaffolds.","authors":"Athira Murali, Ramesh Parameswaran","doi":"10.1080/09205063.2024.2436691","DOIUrl":"https://doi.org/10.1080/09205063.2024.2436691","url":null,"abstract":"The implant surface chemistry and topography are primary factors regulating the success and survival of bone scaffold. Surface modification is a promising alternative to enhance the biocompatibility and tissue response to augment the osteogenic functionalities of polyesters like PLA. The study employed the synergistic effect of alkaline hydrolysis and polydopamine (PDA) functionalization to enhance the cell-material interactions on 3D printed polylactic acid (PLA) scaffold. Comprehensive characterization of the modified PLA highlights the improvements in the physical, chemical and cell-material interactions upon two-step surface modification. The X-ray photoelectron spectroscopy (XPS) analysis substantiated enhanced PDA deposition with a ∼8.2% increase in surface N composition after surface etching due to homogeneous PDA deposition compared to the non-etched counterpart. The changes in surface chemistry and morphology upon dual surface modification complemented the human osteoblast (HOS) attachment and proliferation, with distinct cell morphology and spreading on PDA coated etched PLA (Et-PLAPDA) scaffolds. Moreover, substantial improvement in osteogenic differentiation of UMR-106 cells on etched PLA (Et-PLA) and Et-PLAPDA highlights the suitability of alkali etching-mediated PDA deposition to improve mineralization on PLA. Overall, the present work opens insights to modify scaffold surface composition, topography, hydrophilicity and roughness to regulate local cell adhesion to improve the osteogenic potential of PLA.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-26"},"PeriodicalIF":3.6,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Correction. 修正。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-09 DOI: 10.1080/09205063.2024.2436824

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Natural Fiber-Based Polymer Composites for Biomedical Applications. 生物医学应用的天然纤维基聚合物复合材料。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-09 DOI: 10.1080/09205063.2024.2435722

Emel Kuram

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Development of inulin nanocarrier for effective oral delivery of insulin: synthesize, optimization, characterization, and biophysical study. 有效口服胰岛素的菊糖纳米载体的研制：合成、优化、表征及生物物理研究。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-04 DOI: 10.1080/09205063.2024.2436297

Achmad Ramadhanna'il Rasjava, Desy Kurniawati, Wa Ode Sri Rizki, Neng Fisheri Kurniati, Rukman Hertadi

{"title":"Development of inulin nanocarrier for effective oral delivery of insulin: synthesize, optimization, characterization, and biophysical study.","authors":"Achmad Ramadhanna'il Rasjava, Desy Kurniawati, Wa Ode Sri Rizki, Neng Fisheri Kurniati, Rukman Hertadi","doi":"10.1080/09205063.2024.2436297","DOIUrl":"https://doi.org/10.1080/09205063.2024.2436297","url":null,"abstract":"The susceptibility of insulin against gastric acid degradation presents a major challenge for oral insulin delivery. The potential of biopolymer-based nanocarriers was investigated in order to address this issue. Inulin, a biopolymer produced by the halophilic bacterium Salinivibrio sp. GM01, has been evaluated for its effectiveness as an insulin nanocarrier. Using central composite design (CCD) method, the optimum condition of inulin-encapsulated insulin (I-In) was achieved at 53 mg of inulin stirred at 17,800 rpm for 10 min, resulting in spherical I-In nanoparticles (I-In NPs) with an average diameter of 416 ± 32 nm and encapsulation efficiency of 87.04 ± 3.01%. The insulin release profile of I-In NPs in simulated gastric fluid follows a burst pattern. Biophysical analysis revealed that insulin in I-In NPs had higher conformational stability than the free state (FS) insulin, as evidenced by an increase in denaturation half-life up to 60 min and the transition enthalpy by 0.29 and 1.53 kcal/mol for secondary and tertiary structures, respectively. Furthermore, preliminary in vivo studies showed that I-In NPs showed significant effect compared to FS insulin for up to 15% in blood glucose level reduction. This study demonstrates the potential of I-In NPs as a promising candidate for antidiabetic therapy and an effective oral delivery system.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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In vitro chondrogenic potential of marine biocomposite hydrogel construct for cartilage tissue engineering. 用于软骨组织工程的海洋生物复合水凝胶构建体的体外软骨生成潜能。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-10-21 DOI: 10.1080/09205063.2024.2391223

Sumayya A S, Muraleedhara Kurup G

{"title":"In vitro chondrogenic potential of marine biocomposite hydrogel construct for cartilage tissue engineering.","authors":"Sumayya A S, Muraleedhara Kurup G","doi":"10.1080/09205063.2024.2391223","DOIUrl":"10.1080/09205063.2024.2391223","url":null,"abstract":"Cartilage tissue engineering (CTE) is a field of regenerative medicine focused on constructing ideal substitutes for injured cartilage by effectively combining cells, scaffolds, and stimulatory factors. In vitro CTE employing chondrocytes and biopolymer-based hydrogels has the potential to repair damaged cartilage. In this research, primary chondrocytes were extracted from the rib cartilage of rats and seeded on a hydrogel construct named HACF, which is made from hydroxyapatite, alginate, chitosan, and fucoidan. We then evaluated in vitro chondrogenesis on HACF cartilage construct. The results revealed that the primary chondrocytes were successfully isolated from rat rib cartilage by collagenase D digestion and HACF cartilage construct was effectively synthesized. Chondrocyte viability and its differentiation inside the scaffold HACF were determined by MTT assay, NRU assay, live/dead assay, DAPI nuclear staining, flow cytometry analysis (FCA), mRNA expression studies, and quantification of extracellular matrix components in the HACF scaffold. The findings indicated excellent chondrocyte viability within the HACF scaffold, with no noticeable changes in morphology. Apoptosis was not detected in the chondrocytes cultured on these hydrogels, as confirmed by DAPI staining, live/dead assay, and FCA. This demonstrates that the cells were capable of proliferating, dividing, multiplying, and maintaining their integrity on HACF scaffold. The results also showed more collagen deposition and glycosaminoglycan synthesis showing the good health of chondrocytes on the HACF construct. It indicates that HACF is an ideal scaffold supporting stable cartilage matrix production, highlighting its suitability for cartilage tissue engineering.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2845-2866"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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