Journal of Biomaterials Science, Polymer Edition最新文献_第9页

Design of poly(vinyl pyrrolidone) and poly(ethylene glycol) microneedle arrays for delivering glycosaminoglycan, chondroitin sulfate, and hyaluronic acid 设计用于输送糖胺聚糖、硫酸软骨素和透明质酸的聚乙烯吡咯烷酮和聚乙二醇微针阵列

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-12 DOI: 10.1080/09205063.2024.2392914

Andisheh Choupani, Elif Sevval Temucin, Eda Ciftci, Feray Bakan, Busra Tugba Camic, Guralp Ozkoc, Meltem Sezen, Petek Korkusuz, Feza Korkusuz, Bekir Bediz

引用次数: 0

Robust tissue adhesion in biomedical applications: enhancing polymer stability in an injectable protein-based hydrogel. 生物医学应用中稳健的组织粘附性：增强可注射蛋白质水凝胶中聚合物的稳定性。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-11 DOI: 10.1080/09205063.2024.2398888

Pijush Giri,Daman Yadav,Balaram Mishra,Mukesh Kumar Gupta,Devendra Verma

{"title":"Robust tissue adhesion in biomedical applications: enhancing polymer stability in an injectable protein-based hydrogel.","authors":"Pijush Giri,Daman Yadav,Balaram Mishra,Mukesh Kumar Gupta,Devendra Verma","doi":"10.1080/09205063.2024.2398888","DOIUrl":"https://doi.org/10.1080/09205063.2024.2398888","url":null,"abstract":"Protein-based hydrogels are appealing materials for a variety of therapeutic uses because they are compatible, biodegradable, and adaptable to biological and chemical changes. Therefore, adherent varieties of hydrogels have received significant study; nevertheless, the majority of them show weak mechanical characteristics, transient adherence, poor biocompatibility activity, and low tensile strength. Here we are reporting, a two-component (BSA-gelatin) protein solution crosslinked with Tetrakis (hydroxymethyl) phosphonium chloride (THPC) to form a novel hydrogel. Compared with classical adhesive hydrogels, this hydrogel showed enhanced mechanical properties, was biocompatible with L929 cells, and had minimal invasive injectability. A considerable, high tensile strength of 73.33 ± 11.54 KPa and faultless compressive mechanical properties of 173 KPa at 75% strain were both demonstrated by this adhesive hydrogel. Moreover, this maximum tissue adhesion strength could reach 18.29 ± 2.22 kPa, significantly higher than fibrin glue. Cell viability was 97.09 ± 6.07%, which indicated that these hydrogels were non-toxic to L929. The fastest gelation time of the BSA-gelatin hydrogel was 1.25 ± 0.17 min at physiological pH and 37 °C. Therefore, the obtained novel work can potentially serve as a tissue adhesive hydrogel in the field of biomedical industries.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":"12 1","pages":"1-23"},"PeriodicalIF":3.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterial-functionalized electrospun scaffolds for tissue engineering. 用于组织工程的纳米材料功能化电纺支架。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-11 DOI: 10.1080/09205063.2024.2399909

Kilole Tesfaye Chaka,Kai Cao,Tamrat Tesfaye,Xiaohong Qin

{"title":"Nanomaterial-functionalized electrospun scaffolds for tissue engineering.","authors":"Kilole Tesfaye Chaka,Kai Cao,Tamrat Tesfaye,Xiaohong Qin","doi":"10.1080/09205063.2024.2399909","DOIUrl":"https://doi.org/10.1080/09205063.2024.2399909","url":null,"abstract":"Tissue engineering has emerged as a biological alternative aimed at sustaining, rehabilitating, or enhancing the functionality of tissues that have experienced partial or complete loss of their operational capabilities. The distinctive characteristics of electrospun nanofibrous structures, such as their elevated surface-area-to-volume ratio, specific pore sizes, and fine fiber diameters, make them suitable as effective scaffolds in tissue engineering, capable of mimicking the functions of the targeted tissue. However, electrospun nanofibers, whether derived from natural or synthetic polymers or their combinations, often fall short of replicating the multifunctional attributes of the extracellular matrix (ECM). To address this, nanomaterials (NMs) are integrated into the electrospun polymeric matrix through various functionalization techniques to enhance their multifunctional properties. Incorporation of NMs into electrospun nanofibrous scaffolds imparts unique features, including a high surface area, superior mechanical properties, compositional variety, structural adaptability, exceptional porosity, and enhanced capabilities for promoting cell migration and proliferation. This review provides a comprehensive overview of the various types of NMs, the methodologies used for their integration into electrospun nanofibrous scaffolds, and the recent advancements in NM-functionalized electrospun nanofibrous scaffolds aimed at regenerating bone, cardiac, cartilage, nerve, and vascular tissues. Moreover, the main challenges, limitations, and prospects in electrospun nanofibrous scaffolds are elaborated.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":"27 1","pages":"1-43"},"PeriodicalIF":3.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of bio-based polymeric blends - a comprehensive review. 生物基聚合物混合物的开发--综述。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-09 DOI: 10.1080/09205063.2024.2394300

Jaya Maitra,Nikita Bhardwaj

{"title":"Development of bio-based polymeric blends - a comprehensive review.","authors":"Jaya Maitra,Nikita Bhardwaj","doi":"10.1080/09205063.2024.2394300","DOIUrl":"https://doi.org/10.1080/09205063.2024.2394300","url":null,"abstract":"The current impetus to develop bio-based polymers for greater sustainability and lower carbon footprint is necessitated due to the alarming depletion of fossil resources, concurrent global warming, and related environmental issues. This article reviews the development of polymeric blends based on bio-based polymers. The focus on bio-based polymers is due to their greater 'Sustainability factor' as they are derived from renewable resources. The article delves into the synthesis of both conventional and highly biodegradable bio-based polymers, each crafted from feedstocks derived from nature's bounty. What sets this work apart is the exploration of blending existing bio-based polymers, culminating in the birth of entirely new materials. This review provides a comprehensive overview of the recent advancements in the development of bio-based polymeric blends, covering their synthesis, properties, applications, and potential contributions to a more sustainable future. Despite their potential benefits, bio-based materials face obstacles such as miscibility, processability issues and disparities in physical properties compared to conventional counterparts. The paper also discusses significance of compatibilizers, additives and future directions for the further advancement of these bio-based blends. While bio-based polymer blends hold promise for environmentally benign applications, many are still in the research phase. Ongoing research and technological innovations are driving the evolution of these blends as viable alternatives, but continued efforts are needed to ensure their successful integration into mainstream industrial practices. Concerted efforts from both researchers and industry stakeholders are essential to realize the full potential of bio-based polymers and accelerate their adoption on a global scale.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":"42 1","pages":"1-35"},"PeriodicalIF":3.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current strategic arsenal and advances in nose to brain nanotheranostics for therapeutic intervention of glioblastoma multiforme. 目前用于治疗多形性胶质母细胞瘤的鼻脑纳米otheranostics的战略武器库和进展。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-09 DOI: 10.1080/09205063.2024.2396721

Ankit Kumar,Rahul Shukla

{"title":"Current strategic arsenal and advances in nose to brain nanotheranostics for therapeutic intervention of glioblastoma multiforme.","authors":"Ankit Kumar,Rahul Shukla","doi":"10.1080/09205063.2024.2396721","DOIUrl":"https://doi.org/10.1080/09205063.2024.2396721","url":null,"abstract":"The fight against Glioblastoma multiforme (GBM) is ongoing and the long-term outlook for GBM remains challenging due to low prognosis but every breakthrough brings us closer to improving patient outcomes. Significant hurdles in GBM are heterogeneity, fortified tumor location, and blood-brain barrier (BBB), hindering adequate drug concentrations within functioning brain regions, thus leading to low survival rates. The nasal passageway has become an appealing location to commence the course of cancer therapy. Utilization of the nose-to-brain (N2B) route for drug delivery takes a sidestep from the BBB to allow therapeutics to directly access the central nervous system (CNS) and enhance drug localization in the vicinity of the tumor. This comprehensive review provides insights into pertinent anatomy and cellular organization of the nasal cavity, present-day diagnostic tools, intracranial invasive therapies, and advancements in intranasal (IN) therapies in GBM models for better clinical outcomes. Also, this review highlights groundbreaking carriers and delivery techniques that could revolutionize GBM management such as biomimetics, image guiding-drug delivery, and photodynamic and photothermal therapies for GBM management.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":"221 1","pages":"1-35"},"PeriodicalIF":3.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unleashing the power of silk-based proteins as biomaterials for cutting-edge drug delivery: a comprehensive review. 释放丝基蛋白质作为生物材料在尖端药物输送方面的能量：综合综述。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-04 DOI: 10.1080/09205063.2024.2397215

Vishal Kumar Parida, Kavita, Rashmi Arora, Teenu Sharma

{"title":"Unleashing the power of silk-based proteins as biomaterials for cutting-edge drug delivery: a comprehensive review.","authors":"Vishal Kumar Parida, Kavita, Rashmi Arora, Teenu Sharma","doi":"10.1080/09205063.2024.2397215","DOIUrl":"https://doi.org/10.1080/09205063.2024.2397215","url":null,"abstract":"Silk proteins, viz., sericin, fibroin and their modified forms etc., have been thoroughly researched as natural biopolymers for the development of varied nanomaterials exhibiting diverse biomedical applications. The silk proteins are extracted from the cocoons by degumming and treatment with soaps, followed by dissolution and dialysis against water. These proteins exhibit distinct mechanical and physicochemical characteristics including biocompatibility, controlled biodegradability, self-assembling traits, chemical modifiability, and adaptability, thus making it an ideal drug delivery vehicle. In this regard, silk protein-derived drug delivery systems have been reported as efficient carrier to encapsulate and stabilize the wide variety of pharmacological molecules, enzymes, proteins, vaccines, and even DNA, allowing them to remain active for a longer period of time. Further, different delivery carriers researched employing these proteins for multitude of applications include hydrogels, sponges, fibres, scaffolds and particulate delivery systems. Additionally, the chemical modification of silk proteins has further opened avenues for development of other modified silk proteins with improved physicochemical traits and hence exhibiting enormous potential in development of varied bioenhanced carrier systems. The current article thus provides the holistic information of characteristics, types of silk protein-based delivery carriers, and their fabrication techniques, while emphasizing the applications of different silk proteins in biomedicine and drug delivery.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-25"},"PeriodicalIF":3.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of graphene oxide in an injectable hydrogel on the osteogenic differentiation of mesenchymal stem cells. 可注射水凝胶中的氧化石墨烯对间充质干细胞成骨分化的影响

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-03 DOI: 10.1080/09205063.2024.2397211

Yaru Zhu, Tao Wang, Zhen He, Mingchong Liu, Chunfang Zhang, Guixin Sun, Qidong Wang

{"title":"Effect of graphene oxide in an injectable hydrogel on the osteogenic differentiation of mesenchymal stem cells.","authors":"Yaru Zhu, Tao Wang, Zhen He, Mingchong Liu, Chunfang Zhang, Guixin Sun, Qidong Wang","doi":"10.1080/09205063.2024.2397211","DOIUrl":"https://doi.org/10.1080/09205063.2024.2397211","url":null,"abstract":"Graphene oxide (GO) is widely used in bone tissue engineering due to its good biocompatibility and proliferation, and is often used in combination with other hydrogels, which not only reduces the cytotoxicity of GO but also improves the mechanical properties of the hydrogels. We developed injectable carboxymethyl chitosan (CMC)/hydroxyethyl cellulose (HEC)/β-tricalcium phosphate (β-TCP)/GO hydrogel via hydrogen bonding cross-linked between (CMC) and (HEC), also, calcium cross-linked by β-TCP was also involved to further improvement of mechanical properties of the hydrogel, and incorporate different concentration of GO in these hydrogel systems. The characterization of the novel hydrogel was tested by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). The swelling ratio and mechanical properties were investigated, the results showed that the addition of GO was able to reduce the swelling rate of hydrogels and improve their mechanical properties, with the best effect in the case of 1 mg/mL content. In vivo experimental studies showed that the hydrogel significantly promoted the osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs), with the best effect at a concentration of 2 mg/mL. The results of the cellular experiments were similar. Therefore, the novel environment-friendly and non-toxic injectable CMC/HEC/β-TCP/GO hydrogel system may have potential applications in bone tissue engineering.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-17"},"PeriodicalIF":3.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dialysis treatment, in vitro, and anticoagulation activity of polysulfone-polyacrylamide based-blend membranes: an experimental study. 基于聚砜-聚丙烯酰胺的混合膜的透析处理、体外和抗凝活性：一项实验研究。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-03 DOI: 10.1080/09205063.2024.2398325

Shafiq Uz Zaman, Muhammad Shozab Mehdi

{"title":"Dialysis treatment, in vitro, and anticoagulation activity of polysulfone-polyacrylamide based-blend membranes: an experimental study.","authors":"Shafiq Uz Zaman, Muhammad Shozab Mehdi","doi":"10.1080/09205063.2024.2398325","DOIUrl":"https://doi.org/10.1080/09205063.2024.2398325","url":null,"abstract":"The majority of treatments are performed with polysulfone (PSf) membranes. The main issue of the PSf membrane is its lack of endothelial function, leading to various processes like platelet adhesion, protein adsorption, and thrombus formation when comes in contact with blood. The crucial aspect in the development of hemodialysis (HD) membrane materials is a biocompatibility factor. This study aims to improve the performance and biocompatibility of PSf membranes by utilizing polyethylene glycol (PEG) as a pore-forming agent and polyacrylamide (PAA) as a multifunctional modifying additive owing to its non-toxic, and biocompatible nature. The formulated HD membranes were characterized using Fourier Transform Infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), and Water Contact Angle (WCA) measurements. The biocompatibility results showed that PSf-PAA membranes reduced the adsorption of bovine serum albumin (BSA) protein, hemolysis process, thrombus formation, and platelets adhesion with improved in vitro cytotoxicity results as well as anticoagulation performance. The protein separation results showed that PSf-PAA membranes were able to reject 90.1% and 92.8% of BSA protein. The membranes also showed better uremic waste clearance for urea (76.56% and 78.24%) and creatinine (73.71% and 79.13%) solutes, respectively. It is conceivable that these modern-age membranes may surpass conventional HD membranes regarding both efficiency and effectiveness.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-22"},"PeriodicalIF":3.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting SARS-CoV2 spike glycoprotein: molecular insights into phytocompounds binding interactions - in-silico molecular docking. 以 SARS-CoV2 穗状糖蛋白为靶标：植物化合物结合相互作用的分子洞察力 - 室内分子对接。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-03 DOI: 10.1080/09205063.2024.2399395

K Saravanan, S Elavarasi, G Revathi, P Karuppannan, M Ashokkumar, C Muthusamy, A Ram Kumar

{"title":"Targeting SARS-CoV2 spike glycoprotein: molecular insights into phytocompounds binding interactions - in-silico molecular docking.","authors":"K Saravanan, S Elavarasi, G Revathi, P Karuppannan, M Ashokkumar, C Muthusamy, A Ram Kumar","doi":"10.1080/09205063.2024.2399395","DOIUrl":"https://doi.org/10.1080/09205063.2024.2399395","url":null,"abstract":"This study utilized small molecular characterization and docking study to evaluate the binding affinity of seven antiviral phytocompounds with the SARS CoV-2 variants (SARS-CoV-2 Spike Glycoprotein, SARS-CoV-2 Spike Protein Variant in 1-RBD, Alpha Variant SARS-CoV2- Spike Protein). The results revealed that five of seven compounds, possesses excellent drug lead property reveled through in-silico ADMET analysis. In addition, six of seven except D-Glucosamine, exhibited excellent binding affinity. Six ligands possess significant binding affinity towards SARS-CoV-2 variants 6VXX, 7LWV and 7R13, which is certainly greater than Remdesivir. Fagaronine found to be the best drug candidate against SARS-CoV-2 variants, It was found that -7.4, -5.6 and -6.3 is the docking score respectively. Aranotin, Beta aescin, Gliotoxin, and Fagaronine formed hydrogen bonds with specific amino acids and exhibited significant binding interactions. These findings suggest that these phytocompounds could be promising candidates for developing antiviral therapies against SARS-CoV-2. Moreover, the study underscores the importance of molecular docking in understanding protein-ligand interactions and its role in drug discovery. The documented pharmacological properties of these compounds in the literature further support their potential therapeutic relevance in various diseases.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced mucoadhesive properties of ionically cross-linked thiolated gellan gum films. 增强离子交联硫醇化胶凝胶薄膜的粘液粘附性能。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-09-02 DOI: 10.1080/09205063.2024.2397199

Ankita Modi, Reshma Sanal, Ashika Suresh, Manju Saraswathy

{"title":"Enhanced mucoadhesive properties of ionically cross-linked thiolated gellan gum films.","authors":"Ankita Modi, Reshma Sanal, Ashika Suresh, Manju Saraswathy","doi":"10.1080/09205063.2024.2397199","DOIUrl":"https://doi.org/10.1080/09205063.2024.2397199","url":null,"abstract":"Localized oral drug delivery offers several advantages for treating various disease conditions. However, drug retention at the disease site within the oral cavity is indeed a significant challenge due to the dynamic oral environment. The present study aimed to develop a mucoadhesive inner layer for a three-layer mucoadhesive bandage suitable for localized oral drug delivery. using gellan gum (GG) biopolymer. Gellan gum (GG) was modified using L-cysteine moieties via carbodiimide chemistry. Subsequently, gellan gum solution at different extents of thiolation was ionically cross-linked using aluminum ammonium sulfate. Thiolated gellan gum films of uniform thickness were prepared using a solvent casting method. The thickness of bare gellan gum film was 0.035 ± 0.0043 mm, whereas the thiolated gellan gum films, GG 1S and GG 2S showed a thickness of 0.0191 ± 0.0011 mm and 0.0188 ± 0.0004 mm respectively. A high work of adhesion was noted for thiolated gellan gum (GG 2S) with a value of 10 N.mm while using porcine buccal mucosa. An average tensile strength of 48.2 ± 2.46 MPa was measured for thiolated gellan gum films irrespective of the extent of thiolation. The high work of adhesion, favorable cytocompatibility, desirable mechanical properties, and free swell capacity in saline confirmed the suitability of ionically cross-linked thiolated gellan gum films as an inner mucoadhesive layer for the mucoadhesive bandage.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-15"},"PeriodicalIF":3.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0