Journal of Biomaterials Science, Polymer Edition最新文献

{"title":"PEG-grafted dopamine methacrylate-functionalized hydroxyl-terminated PDMS-based silicone hydrogel contact lenses for sustained ocular drug delivery.","authors":"Haoran Pan, Xudong Wu, Shiqin Chen, Defan Zeng, Jinwei Chen, Tao Guo, Jiguo Huang","doi":"10.1080/09205063.2026.2741651","DOIUrl":"https://doi.org/10.1080/09205063.2026.2741651","url":null,"abstract":"<p><p>Ocular drug delivery systems characterized by extended retention time and high bioavailability are urgently required to overcome the limitations of conventional eye drops. In this study, a novel drug-loaded silicone hydrogel contact lens (SHCL) was developed utilizing hydroxyl-terminated polydimethylsiloxane (PDMS-OH) as the silicone matrix, poly(ethylene glycol)-grafted methacryloyldopamine (PEG-MAD) as a functional monomer, and sodium acetyl hyaluronate (SAH) as a surface coating. PEG-MAD was synthesized <i>via</i> a lipase-catalyzed reaction between carboxyl-terminated PEG (PEG-COOH) and methacryloyldopamine (MAD). This synthetic approach not only prevented the oxidation and yellowing of MAD during high-temperature polymerization but also introduced additional hydrogen bonds, thereby enhancing the mechanical properties and drug-loading capacity of the hydrogel. The SHCL was fabricated through free radical polymerization, followed by drug loading (using levofloxacin as a model drug) and SAH coating. The optimized SHCL exhibited a water content of 59.5%, high optical transmittance (91% in the visible light region), and no ocular irritation (as evaluated by the CAM test, with an irritation score of 0). Compared to control groups lacking PEG-MAD or using 3-(Methacryloyloxy)propyltris(trimethylsiloxy)silane (TRIS) as the silicone matrix, the developed SHCL demonstrated a higher drug-loading capacity (3.28 μg/mg dry gel) and sustained drug release over 96 h, along with a significant reduction in human serum albumin adsorption. These findings indicate that the PEG-MAD-functionalized, PDMS-OH-based SHCL holds considerable promise for clinical applications in ocular drug delivery.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-14"},"PeriodicalIF":3.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microneedle-based technology for treating hair loss disorders - an emerging trend for managing alopecia.","authors":"Sathyaraj Weslen Vedakumari, Lokesh Prabakaran, Atchaya Jeevahan, Yovan Raja Pravin","doi":"10.1080/09205063.2026.2734518","DOIUrl":"https://doi.org/10.1080/09205063.2026.2734518","url":null,"abstract":"<p><p>Hair loss or alopecia is a universal problem faced by both men and women around the world. An individual's self-esteem is affected by alopecia, and it may lead to psychological stress and anxiety. Topical minoxidil, oral finasteride, and hair transplantation are the common procedures for treating alopecia. But these approaches are associated with various challenges due to high cost, poor patient compliance, and undesired side effects, thereby demanding new strategies for treating alopecia. Identifying novel approaches to treat alopecia has long been a major concern of dermatological research. Recently, microneedles (MNs) have received enormous attention in the field of transdermal drug delivery due to their biocompatible, noninvasive, and painless approach. They are micron-sized needles that have received huge attention in hair loss treatment. MNs can improve the efficiency of drugs as they can puncture the stratum corneum and release the therapeutic molecules at the site of action. This review highlights the potential use of MN-based therapies in treating alopecia. The various phases of hair growth, types of alopecia, and the role of MNs in promoting hair growth are discussed.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and characterization of a natural amphiphilic complex from soy lecithin and fenugreek extract for improved drug solubility and delivery.","authors":"Avnish Kumar, Gulshan Rathore, Anurag Verma","doi":"10.1080/09205063.2026.2743121","DOIUrl":"https://doi.org/10.1080/09205063.2026.2743121","url":null,"abstract":"<p><p>The low water solubility of hydrophobic drugs continues to be a critical challenge in drug formulations due to its impact on bioavailability and efficacy. While synthetic amphiphilic polymers are commonly applied to increase solubility, their toxicity, immunogenicity or environmental impact restricts their use. Here, a new natural amphiphilic complex was prepared from soy lecithin and fenugreek extract as biodegradable and biocompatible materials. The amphiphilic complex was prepared using a solvent-assisted self-assembly method, in which the fenugreek extract (prepared by Soxhlet extraction) was mixed with soy lecithin and then probe sonicated, precipitated and dried. The delivery system was evaluated using dynamic light scattering (DLS), zeta potential, FTIR, transmission electron microscopy (TEM), UV-vis and differential scanning calorimetry (DSC). The amphiphilic complex had an average particle diameter of 201 nm, polydispersity index (PDI) of 0.43, and a zeta potential of -44.51 mV, suggesting stability. FTIR spectroscopy demonstrated the presence of interactions between the molecules, and TEM showed spherical nanostructures (55-160 nm). The CMC was approximately determined at 2.5-3.0 mL of the sample volume in the dilution series (mean value 2.75 mL), (roughly 0.025-0.030 mg/mL), indicating favourable self-assembly. The system was soluble and had a near-neutral pH (6.5 ± 0.2). The material is a self-assembled amphiphilic complex (rather than a copolymer) formed through non-covalent bonding. In conclusion, the complex has good promising physicochemical properties and the future potential of being developed as a nanocarrier; drug loading, release and biological testing should be studied to establish its efficacy as a drug delivery system.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-25"},"PeriodicalIF":3.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in polymeric nanoparticle-based treatment approaches for Wnt β-catenin pathway modulation and adenomatous polyposis coli mutant colorectal cancer.","authors":"Tanvi Maheshwari, Sankha Bhattacharya, Dilpreet Singh","doi":"10.1080/09205063.2026.2736154","DOIUrl":"https://doi.org/10.1080/09205063.2026.2736154","url":null,"abstract":"<p><p>About 80-90% of sporadic instances of colorectal cancer (CRC) are caused by mutations in the adenomatous polyposis coli (APC) gene, which is one of the earliest and most common molecular events. The constitutive activation of the Wnt/β-catenin signalling pathway caused by APC dysfunction promotes unchecked cellular proliferation, tumour initiation, progression, and treatment resistance. Systemic toxicity, insufficient tumour selectivity, and acquired drug resistance continue to restrict treatment results for advanced colorectal cancer (CRC) despite advancements in surgery, chemotherapy, targeted treatments, and immunotherapy. Novel treatment approaches that can address the molecular anomalies linked to APC dysfunction are therefore desperately needed. In this context, a number of treatment modalities have been studied, including small interfering RNA (siRNA), microRNA, CRISPR/Cas-based gene-editing systems, chemotherapeutic drugs, and combination therapy. Polymeric nanoparticles (PNPs) are among the strategies that have shown promise as preclinical delivery systems and have the potential to be translated into clinical settings. Poly(lactic-co-glycolic acid) (PLGA), chitosan, and PEG-based polymeric nanoparticles (PNPs) offer biocompatibility, controlled release, enhanced tumour accumulation, and protection of therapeutic cargo. In addition to critically assessing PNP-mediated medication and gene delivery techniques that target APC-associated Wnt/β-catenin signalling, this review explores the mechanistic significance of APC in colorectal carcinogenesis. The promise of PNPs to enhance APC-focused treatment in colorectal cancer is highlighted by emphasising targeted delivery, therapeutic precision, biomarker-guided techniques, translational hurdles, and future clinical prospects.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-69"},"PeriodicalIF":3.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A LIFU-responsive phase-change nanoplatform enhances hippocampal galantamine exposure and cognitive outcomes in APP/PS1 mice.","authors":"Yihan Chen, Yunda Liu, Jiamei Xie, Shengnan Wang, Dandan Zhou, Ge Song, Yan Dou","doi":"10.1080/09205063.2026.2741654","DOIUrl":"https://doi.org/10.1080/09205063.2026.2741654","url":null,"abstract":"<p><p>Alzheimer's disease (AD) lacks spatiotemporally controllable strategies for drug delivery to deep brain targets. Galantamine (GTM) is clinically used for symptomatic management of AD, yet systemic dosing is constrained by peripheral adverse effects and limited, nonselective brain exposure. Here, we engineered a PEGylated phase-change liposomal nanoplatform co-loading GTM and perfluoropentane (PFP) (PEG-LIP@PFP@GTM) to integrate noninvasive nose-to-brain delivery with low-intensity focused ultrasound (LIFU)-assisted enhancement of GTM exposure in the hippocampal region. PEG-LIP@PFP@GTM showed a hydrodynamic diameter of 158.8 ± 1.6 nm with a PDI of 0.165 ± 0.017, an encapsulation efficiency of 69.26 ± 2.07%, and a drug loading content of 6.37 ± 0.65%. PFP endowed the formulation with thermo-responsive phase-transition behavior and LIFU-enhanced GTM release under physiological-temperature conditions. <i>In vivo</i> fluorescence imaging and <i>ex vivo</i> brain sectioning provided evidence of brain accessibility after intranasal administration, while also identifying 4 h post-dosing as a practical window for hippocampal LIFU irradiation. In APP/PS1 mice, compared with the non-irradiated nanoplatform group, phase-change liposomes combined with hippocampal LIFU irradiation significantly increased PSD95 fluorescence intensity (<i>p</i> = 0.0028) and improved Y-maze novel-arm time (<i>p</i> = 0.0003) and Morris water maze target-quadrant time (<i>p</i> = 0.0237), and significantly reduced the Aβ-positive area (<i>p</i> = 0.0461). Histological examination revealed no overt abnormalities in the nasal mucosa or major peripheral organs under the tested conditions. Collectively, these findings support combining intranasal nanocarrier delivery with externally applied hippocampal LIFU, with LIFU activation providing additional benefit beyond non-irradiated nanocarrier treatment under the tested conditions.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.5,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual pH/glucose-responsive berberine-loaded bioactive glass/carboxymethyl chitosan hydrogel for promoting diabetic wound healing.","authors":"Feiyuye Xie, Jiasheng Chen, Xuanbi Mo, Muxuan Chen, Deqiu Huang, Wen Zhang","doi":"10.1080/09205063.2026.2741657","DOIUrl":"https://doi.org/10.1080/09205063.2026.2741657","url":null,"abstract":"<p><p>Diabetic wounds are characterized by a complex pathological microenvironment involving hyperglycemia-induced oxidative stress, persistent inflammation, bacterial infection and impaired matrix remodeling. In this study, we developed BBGgel, an injectable pH- and glucose-responsive carboxymethyl chitosan/genipin hydrogel incorporating berberine-loaded bioactive glass nanoparticles, for sustained drug delivery and wound microenvironment modulation. BBGgel could be injected to fill irregular wound beds, absorb wound exudate, and rapidly recover its network structure after mechanical disruption. Berberine was efficiently loaded into the bioactive glass nanoparticles with an encapsulation efficiency of 77.06% and released from the hydrogel in a sustained manner over 9 days, with release kinetics responsive to both pH and glucose levels. The 10% BBGgel formulation promotes L929 fibroblast viability and migration, while attenuating H₂O₂-induced intracellular reactive oxygen species (ROS) accumulation. In LPS-stimulated RAW264.7 macrophages, pretreatment with 10% BBGgel downregulated pro-inflammatory genes (IL-6, iNOS) while upregulating anti-inflammatory genes (Arg-1, IL-10). BBGgel also exhibited antibacterial activity against both <i>S. aureus</i> and <i>E. coli in vitro</i>. In a streptozotocin-induced diabetic rat model, histological evaluation of BBGgel-treated wounds showed more organized tissue architecture and enhanced collagen deposition. Collectively, these findings suggest that BBGgel represents a promising candidate as a multifunctional pH- and glucose-responsive hydrogel dressing for diabetic wound repair.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.5,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular imprinting-based cryogel membranes for <i>Pseudomonas aeruginosa</i> separation.","authors":"Burcu Akbulut, Muhammed Erkek, Adil Denizli, Handan Yavuz Alagöz","doi":"10.1080/09205063.2026.2734515","DOIUrl":"https://doi.org/10.1080/09205063.2026.2734515","url":null,"abstract":"<p><p>Molecularly imprinted polymers are highly functional materials used for the sensitive and selective separation of a wide range of compounds, from bacteria to heavy metals. Cryogels, a type of polymer that can be utilized in molecular imprinting, are considered strong candidates for various separation processes due to their high versatility and ease of synthesis. <i>Pseudomonas aeruginosa</i> is a common encapsulated, gram-negative, rod-shaped bacterium that can cause diseases in plants and animals, including humans. In this study, <i>P. aeruginosa</i>-imprinted cryogels based on 2-hydroxyethyl methacrylate and N-methacryloyl-L-histidine methyl ester (MAH)-Cu(II) coordination were synthesized, followed by detailed characterization of these materials using FTIR and SEM. Swelling tests were conducted to understand the nature of the material. Adsorption studies using UV-Vis spectroscopy demonstrated a concentration-dependent increase in absorbance, which plateaued at higher concentrations due to pore saturation. The equilibrium adsorption data were analyzed using the Langmuir and Freundlich isotherm models, with the results indicating preferential adsorption and heterogeneous behavior, respectively. The dimensionless separation factor from Langmuir's isotherm confirmed favorable adsorption conditions. Reusability experiments showed that the cryogels could be reused efficiently, maintaining over 90% efficiency across ten adsorption-desorption cycles. MIP cryogel adsorbed more <i>P. aeruginosa</i> than the composition-matched NIP, and relative selectivity coefficients greater than 1 supported template-derived recognition. The maximum experimental adsorption capacity was 61.45 mg g^-1, whereas the Langmuir-fitted maximum adsorption capacity was 52.79 mg g^-1. These results demonstrate proof-of-concept selective recognition under controlled phosphate-buffered saline conditions; validation in mixed microbial populations and complex environmental or clinical matrices is required before practical application.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-17"},"PeriodicalIF":3.5,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From water to medicine: the transformative role of hydrogels in diabetic wound healing.","authors":"Prince Kumar Maurya, Kishore Hazarika, Sanchita Bandyopadhyay-Ghosh, Samit Kumar Nandi, Subrata Bandhu Ghosh","doi":"10.1080/09205063.2025.2599294","DOIUrl":"10.1080/09205063.2025.2599294","url":null,"abstract":"<p><p>Slow tissue repair, chronic inflammation, poor angiogenesis, and increased susceptibility to infection make diabetic wound healing a significant global medical concern. Hydrogel-based dressing is an innovative approach to diabetic wound treatment, replacing traditional treatments like surgery, antibiotics, and dressings that often fail to restore the complex wound microenvironment. This review focuses on significant advancements in hydrogel formulations, including their composition, properties, and medical uses. It begins with an overview of the diabetic wound healing process and current treatment strategies. Hydrogels provide moist environment for healing, which are three-dimensional networks of hydrophilic polymers that can hold almost 90% of water and are categorized according to their crosslinking technique (physical and chemical) and their source (natural, synthetic, or hybrid). Among these, injectable hydrogels are popular due to their simplicity of use, capacity to fill a variety of irregularly shaped wounds, and <i>in situ</i> gelation, promoting tissue regeneration and reducing the risk of infection. Finally, we conclude with clinical case studies utilizing hydrogels derived from sodium alginate, placenta-derived mesenchymal stem cells (PDMSC), and collagen-polyacrylate-metal-organic frameworks (MOFs) have shown notable results in wound healing, including improved tissue repair, enhanced chronic wound management, and reduced infection. Despite these advancements, hydrogels continue to encounter issues with mechanical strength, degradation control, and large-scale production. Hydrogel-based wound dressings have potential for individualized treatment of diabetic wounds keeps growing as research and biomaterial technologies advance. This review also highlights novel classification, real-world case studies, and emerging clinical trends, providing a comprehensive perspective that is not commonly addressed in existing literature.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2839-2864"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrospun polycarbonate urethane nanofibrous scaffold for dural repair: physico-chemical characterization and in vivo biocompatibility assessment.","authors":"Theerdha V Nair, Prakash Nair, Sachin J Shenoy, Sabareeswaran A, Umashankar P R, Easwer H V, Sithara R, Jasmin Joseph, Ramesh Parameswaran","doi":"10.1080/09205063.2025.2608049","DOIUrl":"10.1080/09205063.2025.2608049","url":null,"abstract":"<p><p>Dural repair of the native dura following trauma or surgery is often challenging due to limitations such as the poor extensibility, regenerative capacity, and the structural integrity of the dura mater. This has led to the rise of dura substitutes, both biological and synthetic, that aim to match the native dura in its strength and elasticity. While the biological dura substitutes are met with immune rejection, scarring or disease transmission risks, scar tissue formation is a major concern in synthetic dura substitutes. In revision surgeries, the chaotic extraction of the scar tissue-encapsulated material causes severe damage to the patient's tissues. This work aims to develop a biologically inert dura substitute by electrospinning biostable polycarbonate urethane. The membrane was characterized in terms of its mechanical strength, stiffness, suture pullout strength, and porosity. The in-vitro cytotoxicity was evaluated in L929 cells by direct contact, MTT and Alamar blue assay. In accordance with ISO 10993, toxicological safety evaluation procedures such as acute systemic toxicity, sensitization, skin irritation, and genotoxicity studies were performed. The material was implanted in rabbit dural defects, with a commercially available Neuro-patch as the control for six months. The gross and histological investigations revealed that the membrane was mechanically resilient with good intraoperative handling characteristics. Furthermore, it was non-toxic, and had minimal to moderate tissue adhesion and did not elicit any chronic inflammatory responses, indicating its potential role in future dura substitute applications.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2813-2838"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer for advanced wound healing: design and mechanism.","authors":"Xiaodan Zhang, Qing Zhang, Chaoxian Chen","doi":"10.1080/09205063.2025.2591271","DOIUrl":"10.1080/09205063.2025.2591271","url":null,"abstract":"<p><p>Smart and rapid wound healing has long been a significant challenge for the medical community. Recent advancements in biomaterials and manufacturing technologies are overcoming the limitations of traditional wound dressings. Notably, reversible light-responsive azobenzene derivatives in elastomer form are emerging as intelligent materials for this purpose. Their reversible photoisomerization properties have extensive applications in wound healing. This study systematically reviews the design principles, strategies, and mechanisms of smart elastomers based on drugs, as well as their applications in various stages of wound healing. When classifying drugs-releasing elastomers by response factors and loaded drugs, we emphasize design strategies based on physical blending and temperature or light microenvironments. Comparing smart elastomers to traditional polymer dressings, this review highlights how the dual presence of photoisomerization and dynamic bonds grants these polymers non-contact, reversible, intelligent adhesive properties. This unique combination enhances drugs delivery efficiency at wound sites while minimizing patient discomfort. The review discusses the advantages, challenges, and future prospects of smart elastomers in wound healing, offering new insights into intelligent drugs delivery systems for wound treatment.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2585-2618"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}