Journal of Biomaterials Science, Polymer Edition最新文献_第3页

Effect of the molar mass of chitosan and film casting solvents on the properties of chitosan films loaded with Mentha spicata essential oil for potential application as wound dressing. 壳聚糖摩尔质量和成膜溶剂对载入薄荷精油的壳聚糖薄膜性能的影响，该薄膜有望用作伤口敷料。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-08-21 DOI: 10.1080/09205063.2024.2390752

Fatima Zahra Gana, Yahia Harek, Nadia Aissaoui, Taib Nadjat, Sarra Abbad, Houria Rouabhi

{"title":"Effect of the molar mass of chitosan and film casting solvents on the properties of chitosan films loaded with Mentha spicata essential oil for potential application as wound dressing.","authors":"Fatima Zahra Gana, Yahia Harek, Nadia Aissaoui, Taib Nadjat, Sarra Abbad, Houria Rouabhi","doi":"10.1080/09205063.2024.2390752","DOIUrl":"10.1080/09205063.2024.2390752","url":null,"abstract":"Chitosan based films endowed with antibacterial features have witnessed remarkable progress as potential wound dressings. The current study aimed at appraising the effects of the molar mass of chitosan (MM) and the film casting acids on the properties of unplasticized chitosan films and plasticized MSO-embedded chitosan films in order to provide best suited film formulation as a potential candidate for wound dressing application. The prepared films were functionally characterized in terms of their qualitative assessment, thickness, density, swelling behavior, water vapor barrier, mechanical and antibacterial properties. Overall, all chitosan films displayed thickness lower than the human dermis even though thicker and denser films were produced with lactic acid. Assessment of the swelling behavior revealed that only high molar mass (HMM) chitosan films may be regarded as absorbent dressings. Moreover, unplasticized HMM lactate (HMM-LA) films furnished lower stiffness and higher percent strain break as compared to acetate films, due to the plasticizing effect of the remaining lactic acid as alluded by the FTIR analysis. Meanwhile, they provided suitable level of moisture and indicated substantial antibacterial activity against S. aureus and E. coli, the most commonly opportunistic bacteria found in infected skin wound. Plasticized chitosan films doped with MSO were significantly thicker and more permeable to water compared to unplasticized films. Furthermore, MSO significantly potentiate the antibacterial effect of chitosan-based films. Therefore, plasticized HMM-LA/MSO chitosan film flashing good swelling behavior, adequate WVTR and WVP, suitable mechanical properties and antibacterial performances substantiated to be a promising antibacterial dressing material for moderately exuding wounds.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2807-2828"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted polymeric primaquine nanoparticles: optimization, evaluation, and in-vivo liver uptake for improved malaria treatment. 靶向聚合伯氨喹纳米粒子：优化、评估和体内肝脏吸收，以改善疟疾治疗。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-09-01 DOI: 10.1080/09205063.2024.2391225

Sarvesh Bhargava, Hitesh Kumar Dewangan, Rohitas Deshmukh

{"title":"Targeted polymeric primaquine nanoparticles: optimization, evaluation, and in-vivo liver uptake for improved malaria treatment.","authors":"Sarvesh Bhargava, Hitesh Kumar Dewangan, Rohitas Deshmukh","doi":"10.1080/09205063.2024.2391225","DOIUrl":"10.1080/09205063.2024.2391225","url":null,"abstract":"Primaquine (PQ) is a widely used antimalarial drug, but its high dosage requirements can lead to significant tissue damage and adverse gastrointestinal and hematological effects. Recent studies have shown that nanoformulations can enhance the bioavailability of pharmaceuticals, thereby increasing efficacy, reducing dosing frequency, and minimizing toxicity. In this study, PQ-loaded PLGA nanoparticles (PQ-NPs) were prepared using a modified double emulsion solvent evaporation technique (w/o/w). The PQ-NPs exhibited a mean particle size of 228 ± 2.6 nm, a zeta potential of +27.4 mV, and an encapsulation efficiency of 81.3 ± 3.5%. Scanning electron microscopy (SEM) confirmed their spherical morphology, and the in vitro release profile demonstrated continuous drug release over 72 h. Differential scanning calorimetry (DSC) thermograms indicated that the drug was present in the nanoparticles, with improved physical stability. Fourier-transform infrared spectroscopy (FTIR) analysis showed no interactions between the various substances in the NPs. In vivo studies in Swiss albino mice infected with Plasmodium berghei revealed that the nanoformulated PQ was 20% more effective than the standard oral dose. Biodistribution studies indicated that 80% of the NPs accumulated in the liver, highlighting their potential for targeted drug delivery. This research demonstrates the successful development of a nanomedicine delivery system for antimalarial drugs, offering a promising strategy to enhance treatment efficacy while reducing adverse effects.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2867-2883"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of ibuprofen/naringenin-coloaded into zein/sodium caseinate nanoparticles: evaluation of antiproliferative activity and apoptosis induction in liver cancer cells. 将布洛芬/柚皮苷复合到玉米蛋白/酪蛋白酸钠纳米颗粒中的制备方法：对肝癌细胞抗增殖活性和凋亡诱导的评估。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-09-01 DOI: 10.1080/09205063.2024.2391653

Hesham S Almoallim, Hossam M Aljawdah, Muruganantham Bharathi, Raja Manickam, Suha Mujahed Abudoleh, Samer Hasan Hussein-Al-Ali, Parthasarathy Surya

{"title":"Fabrication of ibuprofen/naringenin-coloaded into zein/sodium caseinate nanoparticles: evaluation of antiproliferative activity and apoptosis induction in liver cancer cells.","authors":"Hesham S Almoallim, Hossam M Aljawdah, Muruganantham Bharathi, Raja Manickam, Suha Mujahed Abudoleh, Samer Hasan Hussein-Al-Ali, Parthasarathy Surya","doi":"10.1080/09205063.2024.2391653","DOIUrl":"10.1080/09205063.2024.2391653","url":null,"abstract":"Nowadays, liver cancer is one of the most disturbing types of cancer that can affect either sex. Nanoparticles (NPs) of zein/sodium caseinate incorporating ibuprofen (IBU) and naringenin (NAR) have improved bioavailability and a high encapsulation efficiency (EE%). These nanoparticles are uniformly spherical. In vitro, cytotoxicity analysis on HepG2 cell lines, which are used to study human liver cancer, shows that encapsulated drugs (86.49% ± 1.90, and 78.52% ± 1.98 for NAR and IBU, respectively) have significantly lower IC50 values than individual drugs or their combined free form. In addition, the combination indices of 0.623 and 0.155 for IBU and NAR, respectively, show that the two have joint beneficial effects. The scratch wound healing assay results also show that the free drugs and the engineered NPs have a more significant anti-migratory effect than the untreated cells. The designed nanoparticles also reduce angiogenesis and proliferation while inducing apoptosis, according to in vitro results. In conclusion, a new approach to treating liver cancer may lie in the nanoencapsulation of numerous drugs within nanoparticles.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2703-2722"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of bacterial cellulose/acrylic acid-based pH-responsive smart dressings by graft copolymerization method. 用接枝共聚法制备细菌纤维素/丙烯酸基 pH 值响应型智能敷料。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-08-20 DOI: 10.1080/09205063.2024.2389689

Wen Zhang, Xinyue Hu, Fei Jiang, Yirui Li, Wenhao Chen, Ting Zhou

{"title":"Preparation of bacterial cellulose/acrylic acid-based pH-responsive smart dressings by graft copolymerization method.","authors":"Wen Zhang, Xinyue Hu, Fei Jiang, Yirui Li, Wenhao Chen, Ting Zhou","doi":"10.1080/09205063.2024.2389689","DOIUrl":"10.1080/09205063.2024.2389689","url":null,"abstract":"Conventional wound dressings used in trauma treatment have a single function and insufficient adaptability to the wound environment, making it difficult to meet the complex demands of the healing process. Stimuli-responsive hydrogels can respond specifically to the particular environment of the wound area and realize on-demand responsive release by loading active substances, which can effectively promote wound healing. In this paper, BC/PAA-pH responsive hydrogels (BPPRHs) were prepared by graft copolymerization of acrylic acid (AA) to the end of the molecular chain of bacterial cellulose (BC) network structure. Antibacterial pH-responsive 'smart' dressings were prepared by loading curcumin (Cur) onto the hydrogels. Surface morphology, chemical groups, crystallinity, rheological, and mechanical properties of BPPRHs were analyzed by different characterization methods. The drug release behavior under different physiological conditions and bacteriostatic properties of BPPRH-Cur dressings were also investigated. The results of structural characterization and performance studies show that the hydrogel has a three-dimensional mesh structure and can respond to wound pH in a 'smart' drug release capacity. The drug release behavior of the BPPRH-Cur dressings under different environmental conditions conformed to the logistic and Weibull kinetic models. BPPRH-Cur displayed good antimicrobial activity against common pathogens of wound infections such as E. coli, S. aureus, and P. aeruginosa by destroying the cell membrane and lysing the bacterial cells. This study lays the foundation for the development of new pharmaceutical dressings with positive health, economic and social benefits.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2767-2789"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteoconductive composite membranes produced by rotary jet spinning bioresorbable PLGA for bone regeneration. 通过旋转喷射纺生物可吸收聚乳酸（PLGA）生产用于骨再生的骨传导复合膜。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.1080/09205063.2024.2386219

Isabella Caroline Pereira Rodrigues, Karina Danielle Pereira, Augusto Ducati Luchessi, Éder Sócrates Najar Lopes, Laís Pellizzer Gabriel

{"title":"Osteoconductive composite membranes produced by rotary jet spinning bioresorbable PLGA for bone regeneration.","authors":"Isabella Caroline Pereira Rodrigues, Karina Danielle Pereira, Augusto Ducati Luchessi, Éder Sócrates Najar Lopes, Laís Pellizzer Gabriel","doi":"10.1080/09205063.2024.2386219","DOIUrl":"10.1080/09205063.2024.2386219","url":null,"abstract":"Bone defects and injuries are common, and better solutions are needed for improved regeneration and osseointegration. Bioresorbable membranes hold great potential in bone tissue engineering due to their high surface area and versatility. In this context, polymers such as poly(lactic-co-glycolic acid) (PLGA) can be combined with osteoconductive materials like hydroxyapatite (HA) nanoparticles (NPs) to create membranes with enhanced bioactivity and bone regeneration. Rotary Jet spinning (RJS) is a powerful technique to produce these composite membranes. This study presents an innovative and efficient method to obtain PLGA-HA(NPs) membranes with continuous fibers containing homogeneous HA(NPs) distribution. The membranes demonstrated stable thermal degradation, allowing HA(NPs) quantification. In addition, the PLGA-HA(NPs) presented osteoconductivity, were not cytotoxic, and had high cell adhesion when cultured with pre-osteoblastic cells. These findings demonstrate the potential of RJS to produce PLGA-HA(NPs) membranes for easy and effective application in bone regeneration.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2597-2610"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced osteogenesis and antibacterial activity of dual-functional PEEK implants via biomimetic polydopamine modification with chondroitin sulfate and levofloxacin. 通过硫酸软骨素和左氧氟沙星的生物仿生多巴胺修饰增强双功能聚醚醚酮植入物的成骨和抗菌活性。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-08-18 DOI: 10.1080/09205063.2024.2390745

Mengjue Li, Junyan Liu, Yutong Li, Wenyu Chen, Zhou Yang, Yayu Zou, Yi Liu, Yue Lu, Jianfei Cao

{"title":"Enhanced osteogenesis and antibacterial activity of dual-functional PEEK implants via biomimetic polydopamine modification with chondroitin sulfate and levofloxacin.","authors":"Mengjue Li, Junyan Liu, Yutong Li, Wenyu Chen, Zhou Yang, Yayu Zou, Yi Liu, Yue Lu, Jianfei Cao","doi":"10.1080/09205063.2024.2390745","DOIUrl":"10.1080/09205063.2024.2390745","url":null,"abstract":"Polyetheretherketone (PEEK) implants have emerged as a clinically favored alternative to titanium alloy implants for cranial bone substitutes due to their excellent mechanical properties and biocompatibility. However, the biological inertness of PEEK has hindered its clinical application. To address this issue, we developed a dual-functional surface modification method aimed at enhancing both osteogenesis and antibacterial activity, which was achieved through the sustained release of chondroitin sulfate (CS) and levofloxacin (LVFX) from a biomimetic polydopamine (PDA) coating on the PEEK surface. CS was introduced to promote cell adhesion and osteogenic differentiation. Meanwhile, incorporation of antibiotic LVFX was essential to prevent infections, which are a critical concern in bone defect repairing. To our delight, experiment results demonstrated that the SPKD/CS-LVFX specimen exhibited enhanced hydrophilicity and sustained drug release profiles. Furthermore, in vitro experiments showed that cell growth and adhesion, cell viability, and osteogenic differentiation of mouse calvaria-derived osteoblast precursor (MC3T3-E1) cells were significantly improved on the SPKD/CS-LVFX coating. Antibacterial assays also confirmed that the SPKD/CS-LVFX specimen effectively inhibited the growth of Escherichia coli and Staphylococcus aureus, attributable to the antibiotic LVFX released from the PDA coating. To sum up, this dual-functional PEEK implant showed a promising potential for clinical application in bone defects repairing, providing excellent osteogenic and antibacterial properties through a synergistic approach.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2790-2806"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and optimization of acetazolamide nanoparticle-laden contact lens using statistical experimental design for controlled ocular drug delivery. 利用统计实验设计设计和优化含乙酰唑胺纳米颗粒的隐形眼镜，实现眼部药物的可控输送。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-08-19 DOI: 10.1080/09205063.2024.2391233

Disha Chawnani, Ketan Ranch, Chirag Patel, Harshilkumar Jani, Shery Jacob, Moawia M Al-Tabakha, Sai H S Boddu

{"title":"Design and optimization of acetazolamide nanoparticle-laden contact lens using statistical experimental design for controlled ocular drug delivery.","authors":"Disha Chawnani, Ketan Ranch, Chirag Patel, Harshilkumar Jani, Shery Jacob, Moawia M Al-Tabakha, Sai H S Boddu","doi":"10.1080/09205063.2024.2391233","DOIUrl":"10.1080/09205063.2024.2391233","url":null,"abstract":"This study aims to formulate and evaluate Eudragit nanoparticles-laden hydrogel contact lenses for controlled delivery of acetazolamide (ACZ) using experimental design. Eudragit S-100 was selected for the preparation of nanoparticles. The optimization of Eudragit S100 concentration (X1), polyvinyl alcohol concentration (X2), and the sonication time (X3) was attempted by applying a central composite experimental design. Mean size of nanoparticles (nm), percent in vitro drug release and drug leaching from the ACZ-ENs laden contact lens were considered as dependent variables. Nanoparticles-laden contact lens was prepared through the direct loading method and characterized. Optimum check-point formulation was selected based on validated quadratic polynomial equations developed using response surface methodology. The optimized formulation of ACZ-ENs exhibited spherical shape with a size of 244.3 nm and a zeta potential of -13.2 mV. The entrapment efficiency of nanoparticles was found to be 82.7 ± 1.21%. Transparent contact lenses loaded ACZ-ENs were successfully prepared using the free radical polymerization technique. ACZ-ENs incorporated in contact lens exhibited a swelling of 83.4 ± 0.82% and transmittance of 80.1 ± 1.23%. ACZ-ENs showed a significantly lower burst release of the drug when incorporated in the contact lens and release was sustained over a period of 24 h. The sterilized formulation of ACZ-ENs laden contact lens did not show any sign of toxicity in rabbit eyes. ACZ-ENs incorporated in contact lens could be considered as a potential alternative in glaucoma patients due to their ability to provide sustained drug release and thus enhance patient compliance.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2884-2908"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printing chronicles in medical devices and pharmaceuticals: tracing the evolution and historical milestones. 医疗设备和药品中的 3D 打印编年史：追溯演变和历史里程碑。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-08-05 DOI: 10.1080/09205063.2024.2386222

Riya Patel, Shivani Patel, Nehal Shah, Sakshi Shah, Ilyas Momin, Shreeraj Shah

{"title":"3D printing chronicles in medical devices and pharmaceuticals: tracing the evolution and historical milestones.","authors":"Riya Patel, Shivani Patel, Nehal Shah, Sakshi Shah, Ilyas Momin, Shreeraj Shah","doi":"10.1080/09205063.2024.2386222","DOIUrl":"10.1080/09205063.2024.2386222","url":null,"abstract":"The objective of this study is to collect the significant advancements of 3D printed medical devices in the biomedical area in recent years. Especially related to a range of diseases and the polymers employed in drug administration. To address the existing limitations and constraints associated with the method used for producing 3D printed medical devices, in order to optimize their suitability for degradation. The compilation and use of research papers, reports, and patents that are relevant to the key keywords are employed to improve comprehension. According to this thorough investigation, it can be inferred that the 3D Printing method, specifically Fuse Deposition Modeling (FDM), is the most suitable and convenient approach for preparing medical devices. This study provides an analysis and summary of the development trend of 3D printed implantable medical devices, focusing on the production process, materials specially the polymers, and typical items associated with 3D printing technology. This study offers a comprehensive examination of nanocarrier research and its corresponding discoveries. The FDM method, which is already facing significant challenges in terms of achieving optimal performance and cost reduction, will experience remarkable advantages from this highly valuable technology. The objective of this analysis is to showcase the efficacy and limitations of 3D-printing applications in medical devices through thorough research, highlighting the significant technological advancements it offers. This article provides a comprehensive overview of the most recent research and discoveries on 3D-printed medical devices, offering significant insights into their study.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2723-2766"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing bioactivity of Callistemon citrinus (Curtis) essential oil through novel nanoemulsion formulation. 通过新型纳米乳液配方提高 Callistemon citrinus（Curtis）精油的生物活性。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-08-05 DOI: 10.1080/09205063.2024.2386787

Hamta Haghbayan, Roya Moghimi, Yaghoub Sarrafi, Akram Taleghani, Rahman Hosseinzadeh

{"title":"Enhancing bioactivity of Callistemon citrinus (Curtis) essential oil through novel nanoemulsion formulation.","authors":"Hamta Haghbayan, Roya Moghimi, Yaghoub Sarrafi, Akram Taleghani, Rahman Hosseinzadeh","doi":"10.1080/09205063.2024.2386787","DOIUrl":"10.1080/09205063.2024.2386787","url":null,"abstract":"The main focus of this study was to create a stable and efficient nanoemulsion (NE) using Callistemon citrinus essential oil (EO). Various factors affecting the NE's stability were optimized including oil %, Tween 80%, time of sonication, and its accelerated stability was examined. The research also considered the antibacterial, antifungal, and larvicidal effects of the optimized NE (B10). The optimum NE stood out for its stability, featuring a particle size of 33.15 ± 0.32 nm. Analysis via IR spectroscopy confirmed successful EO encapsulation in B10. The formulation remained stable for six months, with B10 showing significantly higher antibacterial and antifungal potency compared to the pure oil. When samples were subjected to tests against Fusarium oxysporum, B10 exhibited a MIC value of 62.5 mg/mL, whereas the pure oil showed a MIC value of 250 mg/mL. This indicates that the B10 formulation was 50 times more effective than the EO. In terms of antibacterial activity against Escherichia coli, the MIC value was 0.256 mg/mL for B10 and 4 mg/mL for the EO. Also, pure oil and B10 displayed larvicidal effects against Chilo suppressalis (Walker) larvae, with B10 eliminating 95.2% of larvae in 48 h. Overall, stable and optimum C. citrinus NE with its strong antimicrobial qualities, shows promise as an effective fungicide and insecticide.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2660-2681"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Composite hydrogels fabricated from CMC-PVA-GG incorporated with ZiF-8 for wound healing applications. 将 CMC-PVA-GG 与 ZiF-8 结合制成复合水凝胶，用于伤口愈合。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-08-07 DOI: 10.1080/09205063.2024.2386224

Tooba Yasin, Muhammad Azhar Aslam, Haamid Jamil, Abdalla Abdal-Hay, Hassan Fouad, Humaira Masood Siddiqi, Muhammad Umar Aslam Khan

{"title":"Composite hydrogels fabricated from CMC-PVA-GG incorporated with ZiF-8 for wound healing applications.","authors":"Tooba Yasin, Muhammad Azhar Aslam, Haamid Jamil, Abdalla Abdal-Hay, Hassan Fouad, Humaira Masood Siddiqi, Muhammad Umar Aslam Khan","doi":"10.1080/09205063.2024.2386224","DOIUrl":"10.1080/09205063.2024.2386224","url":null,"abstract":"The skin is at risk for injury to external factors since it serves as the body's first line of defense against the external environment. Hydrogels have drawn much interest due to their intrinsic extracellular matrix (ECM) properties and their biomimetic, structural, and durable mechanical characteristics. Hydrogels have enormous potential use in skin wound healing due to their ability to deliver bioactive substances easily. In this study, composite hydrogels were developed by blending guar gum (GG), polyvinyl alcohol (PVA), and carboxymethyl cellulose (CMC) with crosslinker TEOS for skin wound treatment. The structural, surface morphology, surface roughness, and stability features of the composite hydrogels were characterized by several techniques, such as FTIR, SEM-EDX, AFM, and DSC. The increasing ZiF-8 causes more surface roughness, with decreased swelling in different media (Aqueous > PBS > NaCl). The increasing ZiF-8 amount causes less hydrophilic behavior and biodegradation with increasing gel fraction. The cytocompatibility of Zinc imidazolate framework-8 (ZiF-8) based composites was evaluated against fibroblast cell lines by cell viability, proliferation, and cell morphology. The increasing ZiF-8 caused more cell viability and proliferation with proper cell morphology. Hence, the results show that synthesized composite hydrogels may be a potential candidate for numerous wound repair applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2640-2659"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0