Journal of Biomaterials Science, Polymer Edition最新文献

{"title":"Plasma mediated immobilization of metformin on polyethylene: effects on drug release, antibacterial activity, and biocompatibility.","authors":"Štěpán Žídek, Kateřina Štěpánková, Hana Pištěková, Milan Masař, Monika Stupavská, Pavel Sťahel, David Trunec, Miran Mozetič, Pavel Valasek, Marian Lehocky","doi":"10.1080/09205063.2025.2524261","DOIUrl":"https://doi.org/10.1080/09205063.2025.2524261","url":null,"abstract":"<p><p>Metformin, a widely used antidiabetic drug, has gained attention for its potential applications in antimicrobial surfaces, delivery systems, and anticancer therapy. However, immobilizing metformin in a stable, bioactive, and dose-controllable manner onto a chemically inert, hydrophobic surface is challenging. The objective of this study is to immobilize metformin at various concentration (0.5, 1, 2, 5, 10, and 20 g·L^-1) onto low-density polyethylene (LDPE) surfaces by a multistep approach with the aim of creating bioactive coatings. In this approach, LDPE was first treated with a 40 kHz low pressure plasma discharge in air atmosphere, followed by non-covalent attachment of acrylic acid <i>via</i> a grafting technique. Metformin was covalently attached to the surface <i>via</i> N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) and <i>N</i>-Hydroxysuccinimide (NHS) activation, while its presence on the polymer surface was confirmed by Water contact angle (WCA), Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). Sustained metformin release with a shift from Fickian to first-order kinetics was observed at higher drug loading. Antibacterial testing against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> showed no antibacterial effect at the selected concentration levels. Cytocompatibility assays with multipotent mesenchymal cells showed good biocompatibility of modified surfaces, with only dose-dependent cytotoxicity at higher metformin concentrations (>5 g·L^-1). These results demonstrate that despite the absence of antibacterial effects, the developed system offers a promising platform for further biomedical applications requiring controlled drug surface functionalization and retained cytocompatibility.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D bioprinting hydrogel models of neurovascular unit for in vitro diabetic peripheral neuropathy study.","authors":"Yanping Guo, Runze Tian, Zerui Chen, Yuhong Wang, Changjiang Yu, Nanbo Liu, Tucheng Sun, Shuoji Zhu, Tingting Liu, Bin Yao, Ping Zhu","doi":"10.1080/09205063.2025.2524056","DOIUrl":"https://doi.org/10.1080/09205063.2025.2524056","url":null,"abstract":"<p><p>Diabetic peripheral neuropathy (DPN), a prevalent complication of diabetes, caused a significant morbidity and posed a heavy burden on society. Considering the lack of disease models <i>in vitro</i> for DPN and the advantages of 3D bioprinting in disease modeling, we employed 3D bioprinting technology based on GelMA hydrogel to construct neurovascular units to mimic peripheral nerves and vessels <i>in vitro</i>, further we built the pathological microenvironment characteristic of DPN when the treatment of high glucose in these units. Our 3D disease models closely recapitulated <i>in vivo</i> pathological conditions, including oxidative stress and inflammatory responses, which are key hallmarks of DPN. Then we explored the effects of cholesterol on DPN progression using our disease models <i>in vitro</i>. Moreover, the results of RNA-seq analysis revealed that cholesterol stimulation promoted neuron death and inhibited angiogenesis, thereby accelerating the progression of DPN. We identified <i>Fos</i> as a potential therapeutic target, given its role in regulating reactive oxygen species (ROS), neuron death, and transcriptional activity. This study provides valuable insights into the molecular mechanisms underlying the interaction between cholesterol and DPN, and highlights the potential for targeting cholesterol metabolism in the treatment of DPN.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene expression and hormonal signaling in osteoporosis: from molecular mechanisms to clinical breakthroughs.","authors":"Gurinderdeep Singh, Ronald Darwin, Krishna Chandra Panda, Shaikh Amir Afzal, Shashwat Katiyar, Ram C Dhakar, Sangeetha Mani","doi":"10.1080/09205063.2024.2445376","DOIUrl":"10.1080/09205063.2024.2445376","url":null,"abstract":"<p><p>Osteoporosis is well noted to be a universal ailment that realization impaired bone mass and micro architectural deterioration thus enhancing the probability of fracture. Despite its high incidence, its management remains highly demanding because of the multifactorial pathophysiology of the disease. This review highlights recent findings in the management of osteoporosis particularly, gene expression and hormonal control. Some of the newest approaches regarding the subject are described, including single-cell RNA sequencing and long non-coding RNAs. Also, the review reflects new findings on hormonal signaling and estrogen and parathyroid hormone; patient-specific approaches due to genetic and hormonal variation. Potential new biomarkers and AI comprised as factors for improving the ability to anticipate and manage fractures. These hold great potential of new drugs, combination therapies and gene based therapies for osteoporosis in the future. Further studies and cooperation of scientists and clinicians will help to apply such novelties into practical uses in the sphere of medicine in order to enhance the treatment of patients with osteoporosis.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1466-1501"},"PeriodicalIF":3.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional electrospun nanofiber films of polyacrylonitrile and polyvinyl alcohol incorporating rhamnose and therapeutic agents for enhanced healing of infected burn wounds.","authors":"Munaza Ijaz, Madiha Khan","doi":"10.1080/09205063.2024.2449297","DOIUrl":"10.1080/09205063.2024.2449297","url":null,"abstract":"<p><p>Infected burn wounds present significant clinical challenges due to delayed healing and risk of infection, necessitating advanced treatments that offer both antimicrobial and regenerative properties. This study aimed to develop and evaluate multifunctional electrospun nanofiber films incorporating rhamnose (as an angiogenic agent) and therapeutic agents, namely fluticasone, mupirocin, ciprofloxacin, and silver sulfadiazine, for the enhanced healing of infected burn wounds. Nanofibers containing rhamnose, polyacrylonitrile, polyvinyl alcohol and therapeutic agents were fabricated <i>via</i> electrospinning. The nanofibers were characterized chemically and biologically. FTIR confirmed successful drug incorporation, while XRD indicated a reduced crystallinity in drug-loaded nanofibers. SEM analysis revealed bead formation in some formulations. MTT assays demonstrated moderate cytotoxicity, with formulations F2 (containing all components) and F4 (containing all components except silver sulfadiazine) showing enhanced activity due to rhamnose. Antibacterial studies indicated superior efficacy of formulations F1 (containing all components except rhamnose) and F2 against <i>Staphylococcus aureus</i> and <i>Klebsiella pneumoniae</i>, while anti-inflammatory assays highlighted strong ROS inhibition by formulations containing rhamnose. <i>In vivo</i> wound healing studies for 14 days showed faster wound closure and reduced scarring in groups treated with nanofiber formulations F1-F4, particularly those containing multiple active agents, achieving up to 30% faster healing than the control group. The multifunctional nanofibers exhibited promising antimicrobial, anti-inflammatory, and wound-healing properties, making them potential candidates for treating infected burn wounds. Further studies are needed to optimize the formulations for clinical.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1390-1422"},"PeriodicalIF":3.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of physico-chemical properties of different types of orthopedic acrylic cement.","authors":"Elnaz Taghizadeh, Mona Navaei-Nigjeh, Masoud Mirkazemi, Mazda Rad-Malekshahi","doi":"10.1080/09205063.2024.2449304","DOIUrl":"10.1080/09205063.2024.2449304","url":null,"abstract":"<p><p>Analyzing the chemical composition of different kinds of acrylic cement is necessary to understand their properties and suitability for curing bone defects. Conducting various chemical tests can give valuable insight into the composition, viscosity, and performance characteristics of each kind of cement, Therefore, our study aimed to find safety standards and the effectiveness of these products for medical applications. The polymeric characterization was determined by Nuclear Magnetic Resonance (H-NMR) spectroscopy and Fourier-transform infrared spectroscopy (FTIR). Additionally, gel permeation chromatography (GPC) was used to determine the molecular weight of poly methyl methacrylate (PMMA), which was between 4000 and 6000 Mw. The presence of methyl methacrylate (MMA) monomer observed in all cement within two minutes was determined using gas chromatography-mass spectrometry (GC-MS). Moreover, the images of all radiopaque compounds in the cement were evaluated using Field emission scanning electron microscopy (FESEM) and Energy Dispersive X-ray (EDAX-MAP). The study determined the glass transition (Tg) temperature and conducted differential scanning calorimetry (DCS) analysis for each type of cement. In addition, the setting time for various kinds of spinal cord cement was measured to be more than ten minutes. The percentage of benzoyl peroxide in each cement was determined using titration, ranging from 0.6% to 6%. Additionally, cytotoxicity studies were conducted on human osteoblasts (MG63) in cell culture. In this study, we tried to make a trend line for evaluation types of bone cement that would be applicable for both regulatory buddies and researchers in this field.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1343-1363"},"PeriodicalIF":3.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in three-dimensional printing of hydrogel formulations for vascularized tissue and organ regeneration.","authors":"Tien Dat Nguyen, Thanh-Qua Nguyen, Van Toi Vo, Thi-Hiep Nguyen","doi":"10.1080/09205063.2024.2449294","DOIUrl":"10.1080/09205063.2024.2449294","url":null,"abstract":"<p><p>Over the last decades, three-dimensional (3D) printing has emerged as one of the most promising alternative tissue and organ regeneration technologies. Recent advances in 3D printing technology, particularly in hydrogel-derived bioink formulations, offer promising solutions for fabricating intricate, biomimetic scaffolds that promote vascularization. In this review, we presented numerous studies that have been conducted to fabricate 3D-printed hydrogel vascularized constructs with significant advancements in printing integumentary systems, cardiovascular systems, vascularized bone tissues, skeletal muscles, livers, and kidneys. Furthermore, this work also discusses the engineering considerations, current challenges, proposed solutions, and future outlooks of 3D bioprinting.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1423-1465"},"PeriodicalIF":3.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular dynamics in pharmaceutical nanotechnology: simulating interactions and advancing applications.","authors":"Anand Badrivishal Mundada, Pankaj Pradhan, Rajapandi Raju, Y Sarah Sujitha, Parag Arun Kulkarni, Pooja Anand Mundada, Ruchi Tiwari, Pankaj Sharma","doi":"10.1080/09205063.2025.2450150","DOIUrl":"10.1080/09205063.2025.2450150","url":null,"abstract":"<p><p>Molecular Dynamics (MD) simulations are now widely utilized in pharmaceutical nanotechnology to gain deeper understanding of nanoscale processes imperative to drug design. This review has also detailed how MD simulation can be employed in the study of drug-nanocarrier interactions, controlling release of chemical compounds from drug delivery systems and increasing solubility and bioavailability of nanocarriers. Furthermore, MD contributes to examining the drug delivery systems, measuring the toxic effects, and determining biocompatibility of nanomedical systems. With the incorporation of artificial intelligence and the use of hybrid simulation systems, MD has gone a step ahead to model other niches of biology that make a tremendous opening to develop highly selective nanomedications. Nevertheless, with well-known issues such as computational constraints and the discrepancy between in silico and experiment results, MD remains a work in progress, with considerable promise for replacing or supplementing existing approaches to the development of precision medicine and nanomedicine, the continued progression of healthcare hopeful.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1502-1528"},"PeriodicalIF":3.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing & optimisation of dual Ca²⁺ and SO₄^2- ionic cross-linked sericin/pectin microbeads using response surface methodology for colon-specific delivery.","authors":"Wasim Akram, Nitin Singh, Kantrol Kumar Sahu, Navneet Garud","doi":"10.1080/09205063.2025.2450930","DOIUrl":"10.1080/09205063.2025.2450930","url":null,"abstract":"<p><p>Ulcerative colitis, a chronic inflammatory condition of the colon, requires precise and targeted treatment, and polysaccharides, with their pH responsiveness and biodegradability, offer an innovative approach for colon-specific drug delivery. This study aims to develop a highly precise drug delivery system with enhanced therapeutic and targeting efficiency for ulcerative colitis, focusing on the preparation, optimisation, and evaluation of dual cross-linked mesalamine-loaded sericin-pectin (D_CLSPs) micro-beads. These beads utilise the pH-responsive and microflora biodegradability properties of polysaccharides for targeted colon delivery, employing the Response Surface Methodology. Formulated <i>via</i> the ionotropic gelation method with divalent cross-linking ions (Ca²⁺ and SO₄^2-), the D_CLSPs were optimised using a Box-Behnken design to assess the impact of the varying drug, pectin, and sericin polymer proportions. The D_CLSPs were evaluated for entrapment efficiency, thermal behaviour, surface morphology, water uptake, swelling, and in-vitro drug release. Results indicated that spherical beads were successfully developed, with encapsulation efficiency ranging from 65.1% to 95.5%, drug loading between 32.5% and 49.9%, bead sizes of 0.75 mm to 0.92 mm, and degrees of swelling from 0.92 to 1.82. Drug release was controlled by both diffusion and swelling mechanisms, as supported by the Higuchi and Korsmeyer-Peppas models. The optimised formulation demonstrated high drug encapsulation efficiency, pH-responsive swelling, and strong adhesion to the colon, ensuring extended retention at the targeted site. Additionally, the incorporation of sericin enhanced the accuracy of Gaussian fitting for particle size distribution. Overall, the dual cross-linked sericin-pectin beads show potential as mucoadhesive carriers for delivering drugs specifically to the colon.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1364-1389"},"PeriodicalIF":3.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The biomedical frontier of fucoidan and laminarin: emerging insights.","authors":"Gaurav Sanghvi, Deepak A, Suhas Ballal, I A Ariffin, Abhayveer Singh, A Sabarivani, Subhashree Ray, Kamal Kant Joshi, Bhavik Jain","doi":"10.1080/09205063.2025.2523506","DOIUrl":"https://doi.org/10.1080/09205063.2025.2523506","url":null,"abstract":"<p><p>Laminarin and fucoidan, two marine-derived polysaccharides, have garnered attention in biomedical research due to their unique bioactive properties. Laminarin, a β-glucan composed of glucose linked by β-1,3 and β-1,6 glycosidic bonds, and fucoidan, a sulfated polysaccharide, both demonstrate strong biocompatibility, low toxicity, and the ability to modulate cellular behaviors, making them promising candidates for various therapeutic applications. Recent research highlights their roles in tissue engineering, wound healing, drug delivery, and oncology. Laminarin and fucoidan both support cell adhesion, migration, and extracellular matrix deposition, fostering tissue regeneration and wound repair. In drug delivery, both are often incorporated into nano- or microcarriers, where they can enhance targeted delivery, modulate release kinetics, and improve bioavailability due to their bioadhesive and biological activity. Both compounds have also exhibited potential in cancer therapy-laminarin by inducing apoptosis and fucoidan through its anti-angiogenic and immune-modulating properties. Furthermore, their antioxidant and anti-inflammatory characteristics suggest applications in managing chronic inflammatory conditions and neurodegenerative diseases. While laminarin and fucoidan hold immense therapeutic potential, challenges such as scalable production, cost-effectiveness, and maintaining stability in complex environments remain. Future research is needed to address these hurdles and fully harness their biomedical capabilities. This review compiles recent advancements, identifies gaps in knowledge, and outlines future strategies to maximize laminarin's and fucoidan's therapeutic potential, paving the way for innovative medical applications.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-66"},"PeriodicalIF":3.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural and synthetic polymers in burn wound healing.","authors":"Sepehr Zamani, Arian Ehterami, Ahmad Vaez, Mahdi Naeiji, Hasan Maghsoodifar, Seyed Amir Hossein Sadeghi Douki, Maryam Molaee Eshgh Abad, Zohreh Arabpour, Nafiseh Baheiraei, Arash Farahani, Ali R Djalilian, Majid Salehi","doi":"10.1080/09205063.2025.2523505","DOIUrl":"https://doi.org/10.1080/09205063.2025.2523505","url":null,"abstract":"<p><p>Burn wound management presents significant therapeutic challenges due to the pathophysiological complexity of injured tissues, which disrupts healing and heightens risks of infection, dehydration, and scarring. This review systematically analyzes the efficacy of hydrogel- and non-hydrogel-based dressings in acute and sub-acute burn care. Hydrogels with a water content of more than 90% present an environment for healing by way of autolytic debridement, angiogenesis, fibroblast proliferation, and pain relief-they are extremely helpful in partial-thickness burns owing to their cooling and non-adherence characteristics. Additionally, hydrogels can deliver bioactive agents (e.g. antimicrobials) and manage moderate exudate, enhancing their utility in infected wounds. In contrast, non-hydrogel dressings-including foam, nanofiber, and film-based systems-are tailored for heavily exudative or deep burns (e.g. full-thickness injuries). Foam dressings combine high absorbency with mechanical protection, while electrospun nanofibers mimic the extracellular matrix to accelerate cell migration. Key determinants for polymer selection include hydrophilicity, adhesion properties, wound depth, exudate volume, and microbial load. Natural polymers like chitosan and alginate enhance biocompatibility and antimicrobial activity, whereas synthetic variants (e.g. polyurethane) provide mechanical stability. Composite systems integrate these advantages but face scalability limitations. Emerging innovations, such as pH-responsive and sensor-integrated smart dressings, alongside biomimetic designs, promise advancements in personalized burn care. This review examines the types of polymeric wound dressings and their strengths and weaknesses, addresses current limitations, and leverages technological advances to develop appropriate dressing solutions that can transform burn management paradigms.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-66"},"PeriodicalIF":3.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}