{"title":"Advancements in cartilage tissue regeneration: harnessing nano- and microtechnology for enhanced mesenchymal stem cells delivery in osteoarthritis treatment.","authors":"Ayush Rohila, Kailash Ahirwar, Rahul Shukla","doi":"10.1080/09205063.2025.2555736","DOIUrl":"https://doi.org/10.1080/09205063.2025.2555736","url":null,"abstract":"<p><p>Osteoarthritis (OA), a debilitating condition linked to aging and injury, lacks effective treatments due to limited cartilage repair. Conventional methods often fall short, prompting exploration of innovative solutions. Mesenchymal stem cell (MSC) therapy exhibits potential in the treatment of OA by stimulating the growth of new cartilage and diminishing inflammation. However, limited cell survival and retention hinder its effectiveness. Nano- and microcarrier technology offers a groundbreaking approach. By encapsulating and delivering MSCs, these biomaterial-based carriers improve cell viability and targeted delivery. This review explores recent advancements in nano- and microcarriers, highlighting their potential to overcome limitations of traditional delivery methods in OA therapy. It delves into how these advanced systems facilitate targeted MSC delivery, paving the way for a revolution in cartilage regeneration. By providing a comprehensive understanding of the current state of MSC-based therapy and its synergy with advanced delivery platforms, this review emphasizes the potential of nano- and microcarriers for efficient and long-lasting OA treatment.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-37"},"PeriodicalIF":3.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tröger's base-functionalized chitosan: design, synthesis & evaluation for drug delivery and antioxidant applications.","authors":"Preeti Jaiswal, Ruchi Chawla, Pradip Kumar Dutta","doi":"10.1080/09205063.2025.2558694","DOIUrl":"https://doi.org/10.1080/09205063.2025.2558694","url":null,"abstract":"<p><p>To explore the use of Tröger's Base (TB) in conjunction with chitosan (CS) chemistry, we constructed a stable TB-functionalized chitosan (TB@CS) conjugate by covalently linking a TB to chitosan <i>via</i> imine linkages. The structural and chemical characterization of TB@CS was conducted using FT ̶ IR, PXRD, NMR (<sup>1</sup>H,<sup>13</sup>C CP/MAS,<sup>1</sup>H ̶ <sup>1</sup>H COSY, <sup>1</sup>H-<sup>13</sup>C HSQC/HETCOR), DLS, FE ̶ SEM and zeta potential analyses. The synthesized conjugate exhibited better antioxidant properties against DPPH and ABTS assays than native chitosan. Moreover, DLS & zeta potential analyses of TB@CS revealed a nanometer size range (200.6 nm) and excellent colloidal stability (49.0 ± 4.8 mV) supporting its suitability as a drug delivery system. Curcumin (Cur) was used as a hydrophobic anticancer drug for drug delivery studies. Cur loaded conjugate Cur ̶ TB@CS showed exceptional drug loading efficiency (95.5 ± 1.9%) and drug loading content (31.4 ± 2.5%), probably due to the inherent host-guest chemistry of TBs. <i>In vitro</i> drug release studies demonstrated the pH-dependent behavior of Cur ̶ TB@CS with accelerated release observed under tumor-like acidic conditions compared to physiological pH. The cytotoxicity studies against A549 cancer and PBMCs healthy cell lines, suggested its potential as a promising drug delivery carrier for cancer therapy.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gum Odina in focus: modification strategies, extensive characterization multifunctional applications, and comparative assessment with conventional gums.","authors":"Dhiman Roy, Arindam Sarkar, Adarsha Bachhar, Ushasi Das, Sanchita Mandal","doi":"10.1080/09205063.2025.2558696","DOIUrl":"https://doi.org/10.1080/09205063.2025.2558696","url":null,"abstract":"<p><p>Natural exudates like Gum Odina, a complex polysaccharide, released by plants upon injury, is in high demand for applications such as food additives, emulsifiers, and binders owing to its safety, non-toxicity, and commercial viability, particularly within the pharmaceutical industry. This gum, composed of D-galactose, L-arabinose, aldobiouronic acid, and D-galacturonic acid, exhibits medicinal properties and has been explored for drug administration methods. Rheological studies revealed that Gum Odina dispersions possessed pseudoplastic characteristics, with viscosity increasing with concentration but decreasing with elevated temperature and salinity. Comprehensive analyses, including FTIR, XRD, AFM, TGA, DSC, Raman, CD spectroscopy, and NMR, were conducted to understand its properties. Furthermore, Gum Odina has demonstrated <i>in vitro</i> antioxidant activities against hydroxyl and superoxide radicals, indicating a significant antioxidant capacity. The inherent modifiability of Gum Odina, through chemical or biochemical means such as cross-linking, grafting, fabrication of spongy scaffolds, and coacervates, alters the gum's polysaccharide structure to enhance specific performance characteristics such as solubility, viscosity, swelling capacity, and gelation behavior, enabling customization for commercial and therapeutic applications. This review article explores Gum Odina's novel modification strategies, comprehensive physicochemical characterization, and diverse multifunctional applications, particularly in pharmaceutical preparations. The review highlights Gum Odina's tailored properties and compares its structural, functional, and rheological attributes to conventional plant gums like acacia gum. This review also addresses the economic importance, safety, biodegradability, and biocompatibility of Gum Odina, positioning it as a suitable natural, eco-friendly excipient. Its unique arabinogalactan polymer structure offers advantages over traditional gums in biopolymer application.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-42"},"PeriodicalIF":3.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sambhavi Swarn, Ali M Alaseem, Sachin Sharma, Arghya Paria, Bhupendra G Prajapati, Glowi Alasiri, Sonam M Gandhi, Devesh U Kapoor
{"title":"Gossypol-based nanocarriers for cancer treatment: advances and future perspectives.","authors":"Sambhavi Swarn, Ali M Alaseem, Sachin Sharma, Arghya Paria, Bhupendra G Prajapati, Glowi Alasiri, Sonam M Gandhi, Devesh U Kapoor","doi":"10.1080/09205063.2025.2554978","DOIUrl":"https://doi.org/10.1080/09205063.2025.2554978","url":null,"abstract":"<p><p>Gossypol, a polyphenolic aldehyde derived from cotton plants, has emerged as a potent natural anticancer agent due to its ability to modulate multiple cellular pathways, including apoptosis, angiogenesis, and cell cycle arrest. Despite its promising therapeutic potential, the clinical application of gossypol has been limited by poor aqueous solubility, rapid metabolism, systemic toxicity, and low bioavailability. Nanocarrier-based drug delivery systems offer an innovative strategy to overcome these challenges, enabling targeted delivery, enhanced stability, and reduced off-target effects. This review comprehensively discusses the pharmacological profile of gossypol, its mechanisms of anticancer action, and the limitations associated with its conventional use. The review explores a diverse array of nanocarrier platforms such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, dendrimers, micelles, and hybrid systems that have been engineered to improve gossypol's therapeutic index in both <i>in vitro</i> and <i>in vivo</i> models. Furthermore, the review addresses the formulation challenges, toxicity concerns, and regulatory barriers associated with nanocarrier development. Finally, the review highlights emerging trends, including exosome-mediated delivery and biomimetic systems, and discusses the future of personalized nanomedicine and translational pathways for clinical adoption. Gossypol-loaded nanocarriers represent a promising frontier in cancer therapy, potentially bridging the gap between natural product efficacy and clinical applicability.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karan A Maniar, Bindu Kumari Nagendra Yadav, Shreeraj Shah
{"title":"Lipidic nanocarriers for the treatment of schizophrenia: progress and prospects of solid lipid nanoparticles and nanostructured lipid carriers.","authors":"Karan A Maniar, Bindu Kumari Nagendra Yadav, Shreeraj Shah","doi":"10.1080/09205063.2025.2554131","DOIUrl":"https://doi.org/10.1080/09205063.2025.2554131","url":null,"abstract":"<p><p>Schizophrenia is a persistent and incapacitating neuropsychiatric condition that presents considerable obstacles regarding pharmacological administration and therapeutic effectiveness. Lipidic nanocarriers, including Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs), have emerged as effective drug delivery vehicles for enhancing the bioavailability, stability, and controlled release of antipsychotic medicines. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have several benefits, such as improved drug loading capacity, less systemic adverse effects, and superior efficacy in traversing the blood-brain barrier compared to conventional formulations. This study examines advancements in the development of solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) for schizophrenia therapy, emphasising their potential to improve cerebral medication delivery, extend drug release duration, and decrease administration frequency. Moreover, the essay discusses the difficulties related to the scaling of lipid-based nanocarriers, regulatory obstacles, long-term safety concerns, and the necessity for personalised treatment strategies. Notwithstanding the encouraging results in preclinical models, other challenges persist, including the necessity for enhanced formulation methodologies, safety validation, and regulatory clarity. Future possibilities entail the advancement of personalised nanomedicine platforms and intelligent nanocarriers that respond to particular stimuli, perhaps transforming schizophrenia treatment through more targeted, efficient, and individualised treatments.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-25"},"PeriodicalIF":3.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent advances in biodegradable biosensors for biomedical and environmental applications.","authors":"Haya Akkad, Kaan Keçeci, Esma Ahlatcıoğlu Özerol","doi":"10.1080/09205063.2025.2554132","DOIUrl":"https://doi.org/10.1080/09205063.2025.2554132","url":null,"abstract":"<p><p>Biodegradable biosensors represent a transformative advancement in sustainable sensing technology, offering an environmentally friendly and biocompatible alternative to traditional sensors. This review examines recent advancements, material innovations, degradation mechanisms, and application areas of biodegradable biosensors within the biomedical and environmental sectors. Natural and synthetic biodegradable polymers, such as chitosan, silk fibroin, alginate, PLA, PLGA, and PVA, are assessed for their functional contributions to sensing platforms. Applications, ranging from implantable cardiovascular and neural sensors to soil nutrient monitors and gas detectors, are detailed with corresponding performance data. Although challenges related to signal stability, integration, and long-term operation persist, future research emphasizes multifunctionality, wireless communication, energy autonomy, and AI-driven diagnostics. This review highlights the potential of biodegradable biosensors to transform health monitoring, environmental assessment, and personalized medicine by aligning technological functionality with principles of sustainability.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dolguyaana Sidorova, Nikolai Sleptsov, Aleksandr Spiridonov, Afanasii Dyakonov, Ivan Troev, Gennadiy Palshin, Okhlopkova Aitalina
{"title":"A comparison of UHMWPE-based materials for joint replacement liners by various manufacturers.","authors":"Dolguyaana Sidorova, Nikolai Sleptsov, Aleksandr Spiridonov, Afanasii Dyakonov, Ivan Troev, Gennadiy Palshin, Okhlopkova Aitalina","doi":"10.1080/09205063.2025.2551925","DOIUrl":"https://doi.org/10.1080/09205063.2025.2551925","url":null,"abstract":"<p><p>The survey assessed tribological properties of the materials based on ultra-high-molecular-weight polyethylene for joint replacement liners by several major manufacturers. Being their crucial parameter, the mass wear rates were compared. Scanning electron microscopy was used to assess the metamorphosis of the materials surface after friction. With its help, the morphology of the surfaces with wear particles was assessed. Using IR spectroscopy, oxygen-containing functional groups were identified on the friction surfaces, which were formed during tribooxidative processes. The tribological properties of the materials were compared with their thermal and structural properties.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-13"},"PeriodicalIF":3.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"QbD-optimized curcumin-lignin nanoparticle spray for targeted wound infection therapy against <i>Escherichia coli</i> and <i>Mycobacterium smegmatis</i>.","authors":"Muskan Goyal, Naman Batra, Harish Vishkarma, Lubna Siddiqui, Saurabh Mittal, Garima Sharma, Vartika Mathur, Sushama Talegaonkar","doi":"10.1080/09205063.2025.2551917","DOIUrl":"https://doi.org/10.1080/09205063.2025.2551917","url":null,"abstract":"<p><p>Chronic wounds infected with multidrug-resistant bacteria pose a significant therapeutic challenge, requiring biocompatible and effective interventions. This study presents a novel lignin-based nanoparticle spray for the localized delivery of curcumin, a natural anti-inflammatory and antimicrobial compound. Lignin, a sustainable polyphenolic biopolymer with inherent antioxidant and antimicrobial activities, was used both as a carrier and functional agent. Curcumin-loaded lignin nanoparticles (CLLNPs) were synthesized using a dialysis-based solvent displacement method and optimized through a Quality by Design approach. These nanoparticles were incorporated into a Eudragit-L100-based film-forming spray for targeted skin application. The optimized CLLNPs exhibited a mean particle size of 119.2 ± 2.1 nm, PDI of 0.167, zeta potential of -21.5 mV, and high encapsulation efficiency (97.58 ± 0.67%). The spray dried quickly within 60 s, showed good film uniformity, mechanical stability, and a skin-compatible pH of 6.21. <i>In vitro</i> release followed Higuchi kinetics, with 88.76% curcumin released within 6 h. <i>Ex vivo</i> skin permeation studies demonstrated enhanced drug penetration (165.62 µg/cm<sup>2</sup>/h), and CLSM confirmed uniform, deep nanoparticle penetration into skin layers. The formulation exhibited strong antibacterial activity against both Gram-negative <i>Escherichia coli</i> and Gram-positive <i>Mycobacterium smegmatis</i>, along with potent antioxidant activity (91.85% DPPH scavenging at 500 µg/mL). Together, these findings highlight the potential of lignin-based nanocarriers to offer a synergistic, sustainable, and patient-friendly approach to wound healing and infection control, aligning with the goals of personalized medicine.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-33"},"PeriodicalIF":3.6,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}