Journal of Biomaterials Science, Polymer Edition最新文献_第4页

Enhancing therapeutic effects alginate microencapsulation of thyme and calendula oils using ionic gelation for controlled drug delivery. 利用离子凝胶技术提高百里香和金盏花油的藻酸盐微胶囊治疗效果，实现可控给药。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-08-18 DOI: 10.1080/09205063.2024.2386220

Cengizhan Çakır, Elif Hatice Gürkan

{"title":"Enhancing therapeutic effects alginate microencapsulation of thyme and calendula oils using ionic gelation for controlled drug delivery.","authors":"Cengizhan Çakır, Elif Hatice Gürkan","doi":"10.1080/09205063.2024.2386220","DOIUrl":"10.1080/09205063.2024.2386220","url":null,"abstract":"This study focuses on encapsulating and characterizing essential oils such as thyme and calendula oils, which are known for their therapeutic properties but are limited in pharmaceutical formulations due to their low water solubility and instability, with alginate microspheres. Alginate presents an excellent option for microencapsulation due to its biocompatibility and biological degradability. The ionic gelation (IG) technique, based on the ionic binding between alginate and divalent cations, allows the formation of hydrogel materials with high water content, mechanical strength, and biocompatibility. The microspheres were characterized using FT-IR, SEM, and swelling analyses. After determining the encapsulation efficiency and drug loading capacity, the microspheres were subjected to dissolution studies under simulated digestion conditions. It was observed that the swelling percentage of the microspheres in simulated gastric fluid (SGF) ranged from ∼15% to 100%, while in simulated intestinal fluid (SIF) it ranged from ∼150% to 325%. Thyme oil, with low viscosity, exhibited higher encapsulation efficiency than marigold oil. The highest encapsulation efficiency was observed in A-TO-2 microspheres, while the highest drug loading capacity was observed in A-TO-5 microspheres. During the examination of the dissolution profiles of the microspheres, dissolution rates ranging from 10.98% to 23.56% in SGF and from 52.44% to 63.20% in SIF were observed.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2611-2639"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication, optimization, and in vitro validation of penicillin-loaded hydrogels for controlled drug delivery. 用于控制药物输送的青霉素负载水凝胶的制造、优化和体外验证。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-08-18 DOI: 10.1080/09205063.2024.2387953

Guiyue Wang, Susu An, Siru Huang, Alamgir, Abdul Wahab, Zahoor Ahmad, Muhammad Suhail, M Zubair Iqbal

{"title":"Fabrication, optimization, and in vitro validation of penicillin-loaded hydrogels for controlled drug delivery.","authors":"Guiyue Wang, Susu An, Siru Huang, Alamgir, Abdul Wahab, Zahoor Ahmad, Muhammad Suhail, M Zubair Iqbal","doi":"10.1080/09205063.2024.2387953","DOIUrl":"10.1080/09205063.2024.2387953","url":null,"abstract":"Bacterial infections present a major global challenge. Penicillin, a widely used antibiotic known for its effectiveness and safety, is frequently prescribed. However, its short half-life necessitates multiple high-dose daily administrations, leading to severe side-effects. Therefore, this study aims to address these issues by developing hydrogels which control the release of penicillin and alleviate its adverse effects. Various combinations of aspartic acid and acrylamide were crosslinked by N', N'-methylene bisacrylamide through a free radical polymerization process to prepare aspartic acid/acrylamide (Asp/Am) hydrogels. The fabricated hydrogels underwent comprehensive characterization to assess physical properties and thermal stability. The soluble and insoluble fractions and porosity of the synthesized matrix were evaluated by sol-gel and porosity studies. Gel fraction was estimated at 88-96%, whereas sol fraction was found 12-4% and porosity found within the 63-78% range for fabricated hydrogel formulations. Maximum swelling and drug release were seen at pH 7.4, demonstrating a controlled drug release from hydrogel networks. The results showed that swelling, porosity, gel fraction, and drug release increased with higher concentrations of aspartic acid and acrylamide. However, integration of N', N'-methylene bisacrylamide exhibited the opposite effect on swelling and porosity, while increasing gel fraction. All formulations followed the Korsymer-Peppas model of kinetics with 'r' values within the range of 0.9740-0.9980. Furthermore, the cytotoxicity study indicated an effective and safe use of hydrogel because the cell viability was higher than 70%. Therefore, these prepared hydrogels show promise candidates for controlled release of Penicillin and are anticipated to be valuable in clinical applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2682-2702"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-dimensional porous polycaprolactone/chitosan/bioactive glass scaffold for bone tissue engineering. 用于骨组织工程的三维多孔聚己内酯/壳聚糖/生物活性玻璃支架。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-12-01 Epub Date: 2024-08-26 DOI: 10.1080/09205063.2024.2391218

Kiran Joy, Sathya Seeli David, Abinaya Shanmugavadivu, Nagarajan Selvamurugan, Prabaharan Mani

{"title":"Three-dimensional porous polycaprolactone/chitosan/bioactive glass scaffold for bone tissue engineering.","authors":"Kiran Joy, Sathya Seeli David, Abinaya Shanmugavadivu, Nagarajan Selvamurugan, Prabaharan Mani","doi":"10.1080/09205063.2024.2391218","DOIUrl":"10.1080/09205063.2024.2391218","url":null,"abstract":"Three-dimensional (3D) porous scaffolds based on polycaprolactone (PCL)/chitosan (CS)/bioactive glass (BG) nanoparticle composites were fabricated by the freeze-drying technique for bone tissue engineering. The physiochemical properties of the developed PCL/CS/BG scaffolds were studied using FTIR, XRD, EDX and SEM. Furthermore, the swelling degree, porosity, water retention ability, compression strength, in vitro biodegradation, bioactivity and biocompatibility of the scaffolds were examined. The PCL/CS/BG scaffolds with 4 wt. % of BG content presented adequate pore size (106 μm), porosity (156%), water swelling degree (128%), water retention ability (179%), compressive strength (3.7 MPa) and controlled degradation behavior, which could be ideal for bone tissue engineering. The PCL/CS/BG composite scaffolds showed good antimicrobial activity against both test bacteria and fungi. The MTT assay demonstrated the biocompatibility of PCL/CS/BG scaffolds against C3H10T1/2 cell line. The Alizarin red staining assay confirmed the osteogenic activity of the PCL/CS/BG scaffolds.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2829-2844"},"PeriodicalIF":3.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and application of phenol-grafted rhamnan sulfate for 3D bioprinting. 用于三维生物打印的苯酚接枝鼠李糖硫酸盐的合成与应用。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-11-26 DOI: 10.1080/09205063.2024.2427499

Ryota Goto, Masahiro Terasawa, Masaru Kojima, Koichi Matsuda, Kaoru Nishiura, Shinji Sakai

{"title":"Synthesis and application of phenol-grafted rhamnan sulfate for 3D bioprinting.","authors":"Ryota Goto, Masahiro Terasawa, Masaru Kojima, Koichi Matsuda, Kaoru Nishiura, Shinji Sakai","doi":"10.1080/09205063.2024.2427499","DOIUrl":"https://doi.org/10.1080/09205063.2024.2427499","url":null,"abstract":"Rhamnan sulfate (RS) is a sulfated polysaccharide extracted from the cell wall of the green alga Monostroma nitidum. Owing to its negative charge, RS interacts with a variety of proteins, enabling various biological activities, such as antiviral, anticoagulant, and antitumor effects. However, RS does not form a stable hydrogel under physiological conditions, which is required for its beneficial biological activities in tissue engineering. To address this limitation, we developed phenol-grafted rhamnan sulfate (RS-Ph), which allows hydrogelation via horseradish peroxidase (HRP)-mediated cross-linking reactions and can be used for 3D bioprinting. Specifically, we synthesized RS-Ph with three different -Ph content: RS-LPh (16.4 mmol/g), RS-MPh (21.3 mmol/g), and RS-HPh (31.7 mmol/g). Surface plasmon resonance measurements revealed that RS-Ph exhibited a maximum binding capacity of more than 8.3 times higher than that of sodium alginate as a negative control. Additionally, a 10% w/v RS-HPh solution formed a hydrogel within 8.2 ± 0.7 s in the presence of 10 U/mL HRP. Furthermore, high-fidelity 3D bioprinting was achieved using an RS-Ph/cellulose nanofiber composite bioink. Our results demonstrate the potential use of bioactive RS-Ph hydrogels in a wide range of tissue engineering fields, including not only bioprinting but also drug delivery systems and wound dressings.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-17"},"PeriodicalIF":3.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-enabled pharmacogenomics: revolutionizing personalized drug therapy. 纳米药物基因组学：个性化药物治疗的革命性变革。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-11-26 DOI: 10.1080/09205063.2024.2431426

Ruchi Tiwari, Dhruv Dev, Maharshi Thalla, Vaibhav Dagaji Aher, Anand Badrivishal Mundada, Pooja Anand Mundada, Krishna Vaghela

{"title":"Nano-enabled pharmacogenomics: revolutionizing personalized drug therapy.","authors":"Ruchi Tiwari, Dhruv Dev, Maharshi Thalla, Vaibhav Dagaji Aher, Anand Badrivishal Mundada, Pooja Anand Mundada, Krishna Vaghela","doi":"10.1080/09205063.2024.2431426","DOIUrl":"https://doi.org/10.1080/09205063.2024.2431426","url":null,"abstract":"The combination of pharmacogenomics and nanotechnology science of pharmacogenomics into a highly advanced single entity has given birth to personalized medicine known as nano-enabled pharmacogenomics. This review article covers all aspects starting from pharmacogenomics to gene editing tools, how these have evolved or are likely to be evolved for pharmacogenomic application, and how these can be delivered using nanoparticle delivery systems. In this prior work, we explore the evolution of pharmacogenomics over the years, as well as new achievements in the field of genomic sciences, the challenges in drug creation, and application of the strategy of personalized medicine. Particular attention is paid to how nanotechnology helps avoid the problems that accompanied the development of pharmacogenomics earlier, for example, the question of drug resistance and targeted delivery. We also review the latest developments in nano-enabled pharmacogenomics, such as the coupling with other nanobio-technologies, artificial intelligence, and machine learning in pharmacogenomics, and the ethical and regulatory aspects of these developing technologies. The possible uses of nanotechnology in improving the chances of pated and treating drug-resistant cancers are exemplified by case studies together with the current clinical uses of nanotechnology. In the last section, we discuss the future trends and research prospects in this dynamically growing area, stressing the importance of further advancements and collaborations which will advance the nano-enabled pharmacogenomics to their maximum potential.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-26"},"PeriodicalIF":3.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the poly (butylene adipate-co-terephthalate)/poly (vinyl alcohol) coated recycled Fe₃O₄ magnetic particle carriers for immobilization penicillin G acylase. 聚（己二酸丁二醇酯-共对苯二甲酸乙二醇酯）/聚（乙烯醇）包覆的再生 Fe3O4 磁性颗粒载体用于固定青霉素 G酰化酶的研究。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-11-26 DOI: 10.1080/09205063.2024.2432142

Monier Alhadi Abdelrahman Mohammed, Nan Wang, Zhenbin Chen, Pen Jin, Xueyan Du, Bin Li

{"title":"Study of the poly (butylene adipate-co-terephthalate)/poly (vinyl alcohol) coated recycled Fe3O4 magnetic particle carriers for immobilization penicillin G acylase.","authors":"Monier Alhadi Abdelrahman Mohammed, Nan Wang, Zhenbin Chen, Pen Jin, Xueyan Du, Bin Li","doi":"10.1080/09205063.2024.2432142","DOIUrl":"https://doi.org/10.1080/09205063.2024.2432142","url":null,"abstract":"In this work, the process began by coating a layer of poly (butylene adipate-co-terephthalate) (PBAT)/poly (vinyl alcohol) (PVA) on the surface of magnetic Fe3O4 particles (MPs) obtained from the nickel slag. Then, it was grafted by glutaraldehyde (GA) to obtain Fe3O4@PBAT/PVA-g-GA MPs, which were used as a carrier. Finally, the immobilized PGA was achieved by forming a covalent bond through the Schiff base reaction. To confirm each stage, employed Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), vibration sample magnetometer (VSM), scanning electron microscope-energy spectroscopy of dispersive x-rays (SEM-EDS), inductively coupled plasma mass spectrometry (ICP-MS), and x-ray photoelectron spectrophotometry (XPS). The immobilization conditions were studied and optimized to improve immobilized PGA stability and catalytic activity. The immobilization of PGA demonstrated its optimal performance under the process conditions. The results were achieved using a 2.5 vol.% enzyme solution concentration, a pH of 8.0, an immobilization time of 24 h, and an immobilization temperature of 37 °C. Under these conditions, the immobilized PGA exhibited an enzyme activity recovery (EAR) of 93.71%, an enzyme activity (EA) of 31,367 U/g, and an enzyme loading capacity (ELC) of 111 mg/g. The operating stability, reusability, and storage stability of Fe3O4@PBAT/PVA-g-GA-PGA MPs were investigated. Comparatively, immobilized PGA exhibited superior operational and storage stability compared to free PGA. Even after 11 repeated uses, the immobilized PGA retained 58% of its initial activity, while the carrier recovery (Re) reached 82%. This indicated that the immobilized PGA MPs offer improved longevity and efficiency, making them a promising choice for practical applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-29"},"PeriodicalIF":3.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofunctionalized polymeric nanoparticles for the enhanced delivery of erlotinib in cancer therapy. 用于增强厄洛替尼在癌症治疗中的给药效果的生物功能化聚合物纳米颗粒。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-11-23 DOI: 10.1080/09205063.2024.2429328

Ruchi Tiwari, Anasuya Patil, Ritu Verma, Varsha Deva, Shashi Ravi Suman Rudrangi, Manish R Bhise, Anjaneyulu Vinukonda

{"title":"Biofunctionalized polymeric nanoparticles for the enhanced delivery of erlotinib in cancer therapy.","authors":"Ruchi Tiwari, Anasuya Patil, Ritu Verma, Varsha Deva, Shashi Ravi Suman Rudrangi, Manish R Bhise, Anjaneyulu Vinukonda","doi":"10.1080/09205063.2024.2429328","DOIUrl":"https://doi.org/10.1080/09205063.2024.2429328","url":null,"abstract":"Erlotinib, a potent epidermal growth factor receptor (EGFR) inhibitor, faces bioavailability challenges due to poor water solubility and stability. This study aims to optimize erlotinib-loaded PLGA nanoparticles using a 32 factorial design to enhance drug delivery and therapeutic efficacy. The effects of PLGA concentration (R1) and NaTPP concentration (R2) on nanoparticle characteristics, including particle size, zeta potential, and polydispersity index (PDI), were investigated. The optimal formulation (F5) was identified and characterized, showing a particle size of 169.1 nm, a zeta potential of 20.0 mV, and a PDI of 0.146, indicating uniform and stable nanoparticles. Transmission electron microscopy (TEM) confirmed spherical nanoparticles with minimal aggregation, while X-ray diffraction (XRD) indicated an amorphous state of erlotinib. Formulation F5 demonstrated an entrapment efficiency of 81.9% and a yield of 83.0%. In-vitro drug release studies revealed a sustained release pattern with 90.0% cumulative release at 48 h, following Zero Order kinetics. Cytotoxicity assays showed low cytotoxicity across various cell lines. Statistical analysis confirmed the significant impact of formulation variables on nanoparticle properties. The systematic optimization of erlotinib-loaded nanoparticles has successfully identified formulation F5 as an optimal candidate with favorable characteristics, including minimal particle size, high stability, controlled drug release, and a safe cytotoxicity profile. Notably, the optimized formulation (F5) enhances therapeutic efficacy through improved bioavailability and targeted delivery, addressing the limitations of conventional therapies. These findings suggest that the optimized erlotinib-loaded nanoparticles hold significant potential for enhanced drug delivery and therapeutic efficacy.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-26"},"PeriodicalIF":3.6,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Development, optimization, and characterization of Eudragit-based nanoparticles for Dasatinib delivery". "用于达沙替尼给药的基于 Eudragit 的纳米颗粒的开发、优化和表征"。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-11-19 DOI: 10.1080/09205063.2024.2427489

Hemanth G, Anasuya Patil, Hariprasad Mg, Moqbel Ali Moqbel Redhwan, Sourav Guha

{"title":"\"Development, optimization, and characterization of Eudragit-based nanoparticles for Dasatinib delivery\".","authors":"Hemanth G, Anasuya Patil, Hariprasad Mg, Moqbel Ali Moqbel Redhwan, Sourav Guha","doi":"10.1080/09205063.2024.2427489","DOIUrl":"10.1080/09205063.2024.2427489","url":null,"abstract":"This study focused on developing and evaluating dasatinib-loaded nanoparticles (DST-NPs) using Eudragit L100 as a polymer matrix for enhanced breast cancer treatment. The optimized formulation exhibited a particle size of 202.1 ± 5.7 nm, a zeta potential of -18 ± 1.01 mV, and an entrapment efficiency of 93.11 ± 0.2%. In-vitro release studies demonstrated sustained drug release from DST-NPs, following Fickian diffusion. Pharmacokinetic studies in rats revealed higher Cmax and AUC0-t for DST-NPs compared to pure DST, indicating improved bioavailability. Tissue distribution studies showed enhanced targeting of DST-NPs, with higher concentrations in the liver and spleen. In vivo efficacy in a DMBA-induced mammary carcinoma model demonstrated that DST-NPs significantly reduced tumor volume, maintained stable body weight, and improved survival rates compared to pure DST. Hematologic analysis indicated a favorable blood profile with DST-NPs, and histopathological examinations confirmed the restoration of normal mammary gland and liver architecture. MTT assays showed higher cytotoxicity of DST-NPs against MCF-7, MDA-MB231, and 4T1 cell lines, with lower IC50 values than pure DST. Stability studies indicated that DST-NPs maintained their properties over six months at various storage conditions. These findings highlight the potential of DST-NPs as an effective nanocarrier system for cancer therapy.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jade powder/PLGA composite microspheres for improved performance as potential bone repair drug carrier. 玉石粉/PLGA 复合微球，作为潜在的骨修复药物载体可提高性能。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-11-13 DOI: 10.1080/09205063.2024.2426397

Xinlu Zhang, Zelin Liao, Chong Han, Junliang Wu, Yifei Yu, Xingyu Chen, Hao Gong, Gaohong He, Xiujuan Zhang

{"title":"Jade powder/PLGA composite microspheres for improved performance as potential bone repair drug carrier.","authors":"Xinlu Zhang, Zelin Liao, Chong Han, Junliang Wu, Yifei Yu, Xingyu Chen, Hao Gong, Gaohong He, Xiujuan Zhang","doi":"10.1080/09205063.2024.2426397","DOIUrl":"https://doi.org/10.1080/09205063.2024.2426397","url":null,"abstract":"Poly (lactic-co-glycolic acid) (PLGA) has been widely used as drug delivery carrier or scaffold for bone repair due to its good biocompatibility, biodegradability, and degradation rate controllability. However, defects, like acidic degradation by-products, are associated with PLGA and restrict its practical applications. Jade powder, leftover from jade polishing process, is a natural material rich in elements of Ca, Si, and Mg while biocompatible and antibacterial. Herein, jade powder/PLGA composite microspheres with different mass ratios were prepared by emulsion solvent evaporation method under the optimized conditions. Characterization from SEM, EDS, FTIR, and surface water contact angle measurements indicated jade powder was successfully combined with PLGA and improved the surface wettability of the microspheres. Moreover, it was proved, through in vitro simulated body fluid test as well as adipose stem cell osteogenesis analysis, that jade powder addition enhanced the pH buffering capacity of the composite microsphere for simulated body fluid, and promoted the in vitro osteogenic activity of adipose stem cells at a certain amount. This study provides new ideas to employ jade powder, a natural material otherwise thrown away as solid waste, for improvement on PLGA performance in bone repair or potentially other biomedical fields.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-13"},"PeriodicalIF":3.6,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation, optimization, and evaluation of ligand-tethered atovaquone-proguanil-loaded nanoparticles for malaria treatment. 用于疟疾治疗的配体系留阿托伐醌-丙二胍负载纳米颗粒的制备、优化和评估。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-11-10 DOI: 10.1080/09205063.2024.2422704

Anasuya Patil, Gurinderdeep Singh, Rajendra Dnyandeo Dighe, Dhruv Dev, Bhaveshkumar A Patel, Samatha Rudrangi, Gaurav Tiwari

{"title":"Preparation, optimization, and evaluation of ligand-tethered atovaquone-proguanil-loaded nanoparticles for malaria treatment.","authors":"Anasuya Patil, Gurinderdeep Singh, Rajendra Dnyandeo Dighe, Dhruv Dev, Bhaveshkumar A Patel, Samatha Rudrangi, Gaurav Tiwari","doi":"10.1080/09205063.2024.2422704","DOIUrl":"https://doi.org/10.1080/09205063.2024.2422704","url":null,"abstract":"This work focused on improving antimalarial therapy through the development and characterization of Atovaquone-Proguanil-loaded nanoparticles employing a 32 factorial design. The nanoparticles were prepared from combinations of Poly(lactic-co-glycolic acid) (PLGA) and Eudragit L100 polymers and different concentrations of PVA (polyvinyl alcohol). Based on the results obtained the formulations were characterized for the particle size, zeta potential, encapsulation efficiency, and percent drug release. Among the nine formulations, F5 proved to be the most favorable in the biophysical parameters with a particle size of 176.3 nm, a zeta potential of -33.5 mV, and an encapsulation efficiency of 86% was found in the present investigation. Experimental dissolution profile analysis indicated that F5 had a slow and controlled-release profile where approximately 92.5%. Besides, cytotoxicity studies employing MTT, LDH (lactate dehydrogenase), and Trypan blue reduction test also supported the biocompatibility of nanoparticles and F5 had the highest cell viability (96%) with the least LDH release of 4%. In stability studies conducted for six months, F5 was found to remain stable regarding physicochemical characteristics and drug release profile at different temperature conditions such as room temperature, 4 °C, and 45 °C. The use of folic acid-functionalized nanoparticles is more effective, according to parasitemia, survival rate, and weight loss in mice treated with the nanoparticles. This is because functionalized nanoparticles could be used to enhance anti-malarial therapies.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.6,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0