Journal of Biomaterials Science, Polymer Edition最新文献_第4页

Characterization, antimicrobial and antioxidant activity of bee bread encapsulated with chitosan nanoparticle. 壳聚糖纳米颗粒包封蜜蜂面包的表征及其抗菌抗氧化活性。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-01 Epub Date: 2024-12-20 DOI: 10.1080/09205063.2024.2441032

Stanley Nnamdi Ogoh, Erkay Özgör

引用次数: 0

Progress in injectable hydrogels for hard tissue regeneration in the last decade. 近十年来用于硬组织再生的可注射水凝胶研究进展。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-01 Epub Date: 2025-01-24 DOI: 10.1080/09205063.2024.2436292

Mahya Keshavarz, Mohsen Mohammadi, Fatemeh Shokrolahi

{"title":"Progress in injectable hydrogels for hard tissue regeneration in the last decade.","authors":"Mahya Keshavarz, Mohsen Mohammadi, Fatemeh Shokrolahi","doi":"10.1080/09205063.2024.2436292","DOIUrl":"10.1080/09205063.2024.2436292","url":null,"abstract":"Bone disorders have increased with increasing the human lifespan, and despite the tissue's ability to self-regeneration, in many congenital problems and hard fractures, bone grafting such as autograft, allograft, and biomaterials implantation through surgery is traditionally used. Because of the adverse effects of these methods, the emergence of injectable hydrogels without the need for surgery and causing more pain for the patient is stunning to develop a new pattern for hard tissue engineering. These materials are formed with various natural and synthetic polymers with a crosslinked network through various chemical methods such as click chemistry, Michael enhancement, Schiff's base and enzymatic reaction and physical interactions with high water absorption which can mimic the environment of cells. The purpose of this research is to review the capabilities of this class of materials in hard tissue regeneration in the last decade through adaptable physical and chemical properties, the ability to fill defect sites with an irregular shape, and the ability to grow hormones or release drugs, in response to external stimuli.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1085-1123"},"PeriodicalIF":3.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Fiber-Based Polymer Composites for Biomedical Applications. 生物医学应用的天然纤维基聚合物复合材料。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-01 Epub Date: 2024-12-09 DOI: 10.1080/09205063.2024.2435722

Emel Kuram

引用次数: 0

Development, in vitro and in vivo evaluation of film forming solutions for transdermal drug delivery of Zaltoprofen. 扎尔托洛芬经皮给药成膜溶液的研制、体外和体内评价。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-01 Epub Date: 2024-12-23 DOI: 10.1080/09205063.2024.2443332

Prajila Alayadan, Avichal Kumar, Sanjana S Prakash, Babiker Bashir, V Bhagya, S Narasimha Murthy, H N Shivakumar

{"title":"Development, in vitro and in vivo evaluation of film forming solutions for transdermal drug delivery of Zaltoprofen.","authors":"Prajila Alayadan, Avichal Kumar, Sanjana S Prakash, Babiker Bashir, V Bhagya, S Narasimha Murthy, H N Shivakumar","doi":"10.1080/09205063.2024.2443332","DOIUrl":"10.1080/09205063.2024.2443332","url":null,"abstract":"Zaltoprofen (ZAL) is a non-steroidal anti-inflammatory drug (NSAID) with a short half-life (∼2.8 h) due to extensive first pass metabolism. In this context, 16 different polymeric film forming solutions (PFFS) of ZAL were developed using different grades of Eudragits, Polyvinylpyrrolidones, Kollicoat MAE 100 P and Hydroxypropyl cellulose as film formers, and polyethylene glycol 400 as a plasticizer in equal parts of ethanol and isopropyl alcohol used as solvents. Of these solutions, F13 composed of Kollicoat MAE 100 P emerged as an optimal PFFS as it quickly formed a saturated film (10.25 ± 0.75 min) that displayed low drying time (3.00 ± 0.46 min), and high in vitro adhesion (2.67 ± 0.58). Ex vivo permeation studies conducted in Franz diffusion cell across porcine skin indicated that F13 displayed significantly higher (p < 0.001) steady state flux (8.64 ± 1.72 µg.cm-2.h-1), shorter lag time (∼3 h) and better skin content (2.55 ± 0.62 µg/mg) compared to other PFFS. Fourier Transform Infrared Spectroscopy (FT-IR) proved the chemical integrity of ZAL in polymeric film formed from F13, while Differential scanning calorimetry (DSC) and X-ray Diffractometry (XRD) proved the \"anti-recrystallization potential\" of PFFS. Anti-inflammatory studies in rats indicated that F13 significantly inhibited (ANOVA, p < 0.001) carrageenan induced paw edema for nearly 12 h compared to topical diclofenac used as standard. In addition, significantly elevated (ANOVA, p < 0.001) analgesic effect was noted in the hot plate test in rats treated with F13 compared to the standard for 12 h proving the superior efficacy of F13. Thus, PFFS by virtue of \"in situ evaporative metamorphosis\" induced supersaturation can be an attractive platform to deliver ZAL transdermally.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1265-1288"},"PeriodicalIF":3.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring multi-functional biopolymer polyhydroxyalkanoates in diabetes treatment. 探索多功能生物聚合物聚羟基烷酸酯在糖尿病治疗中的应用。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-29 DOI: 10.1080/09205063.2025.2510445

Gunjan Adwani, Sharda Bharti, Awanish Kumar

{"title":"Exploring multi-functional biopolymer polyhydroxyalkanoates in diabetes treatment.","authors":"Gunjan Adwani, Sharda Bharti, Awanish Kumar","doi":"10.1080/09205063.2025.2510445","DOIUrl":"https://doi.org/10.1080/09205063.2025.2510445","url":null,"abstract":"Millions of individuals worldwide suffer from a chronic metabolic disorder, diabetes, defined as a reduction in insulin production or sensitivity, which raises blood glucose levels, weakens the immune system, and results in irregularities in the metabolism of carbohydrates, fats, and proteins. Therefore, there is still a high demand for non-invasive ways to administer insulin and other antidiabetics to treat diabetes and suitable therapeutics for wound healing. This generates a need for novel biomaterials that effectively use diabetes-associated therapy. This article emphasized that some special -features of Polyhydroxyalkanoates (PHAs) are biocompatible, biodegradable thermoplastic polyesters used in biomedical applications, expanding the options for bioresorbable polymers having antidiabetic and antimicrobial activities. PHAs can be synthesized into scaffolds and nanomaterials that release insulin and other antidiabetic medications in a sustained and controlled way that could improve treatment results. Research analysis on the application of PHAs as scaffold materials for bioartificial pancreas development offers a biocompatible and structurally supportive environment to encapsulate pancreatic cells. Further, challenges including excessive production costs, requirement for additional clinical setting optimization, and the current status of PHAs in the market are emphasized in this review. Further research is needed to explore the therapeutic potential of PHAs exhaustively in diabetes therapeutics and management.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printing of methacrylated hyaluronic acid/α-TCP composite scaffold for bone defect repair. 3D打印甲基丙烯酸透明质酸/α-TCP复合骨缺损修复支架。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-28 DOI: 10.1080/09205063.2025.2503930

Minjie Shen, Haoran Liu, Zhijia Shen, Yajie Wang, Xiexing Wu, Chunyang Fan, Yongkang Deng, Jinlong Zhang, Liang Hu, Huilin Yang, Chun Liu

{"title":"3D printing of methacrylated hyaluronic acid/α-TCP composite scaffold for bone defect repair.","authors":"Minjie Shen, Haoran Liu, Zhijia Shen, Yajie Wang, Xiexing Wu, Chunyang Fan, Yongkang Deng, Jinlong Zhang, Liang Hu, Huilin Yang, Chun Liu","doi":"10.1080/09205063.2025.2503930","DOIUrl":"https://doi.org/10.1080/09205063.2025.2503930","url":null,"abstract":"Bone defects can occur due to various reasons, such as trauma, infection, congenital disorders, or surgical interventions like tumor removal. This study presents the development and characterization of a novel 3D printable composite ink integrating α-tricalcium phosphate (α-TCP) with a photocuring polymer hyaluronic acid methacrylyol (HAMA) for bone defect repair. The composite bioink was formulated to address the limitations of traditional bioinks and to harness the benefits of α-TCP's osteoconductivity and the mechanical stability provided by photocuring polymers. The resulting HAMA/α-TCP scaffolds were evaluated for their rheological properties, biocompatibility, mechanical strength, and osteogenic potential both in vitro and in vivo. The study demonstrated that the incorporation of α-TCP into the HAMA matrix significantly enhanced the scaffold's mechanical properties and osteogenic differentiation capacity. In vivo studies using a rat skull defect model confirmed the superior bone regenerative potential of the HAMA/α-TCP scaffolds compared to controls. The findings suggest that the HAMA/α-TCP composite scaffolds offer a promising approach for bone defect repair, highlighting their potential for clinical translation in orthopedic applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-21"},"PeriodicalIF":3.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biocompatible PLA/spirulina microparticles via electrospraying for targeted drug delivery in HUVEC and HaCaT cell lines. 生物相容性聚乳酸/螺旋藻微粒电喷涂在HUVEC和HaCaT细胞中的靶向药物递送。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-27 DOI: 10.1080/09205063.2025.2503928

Basak Dalbayrak, Isil Aksan Kurnaz, Sumeyye Cesur, Oguzhan Gunduz, Elif Damla Arısan

{"title":"Biocompatible PLA/spirulina microparticles via electrospraying for targeted drug delivery in HUVEC and HaCaT cell lines.","authors":"Basak Dalbayrak, Isil Aksan Kurnaz, Sumeyye Cesur, Oguzhan Gunduz, Elif Damla Arısan","doi":"10.1080/09205063.2025.2503928","DOIUrl":"https://doi.org/10.1080/09205063.2025.2503928","url":null,"abstract":"Spirulina platensis, well-known for its abundant nutrients and sustainability, shows potential as a microcarrier for various biotechnological uses. However, its natural degradability presents a challenge. Polylactic Acid (PLA) offers a solution due to its biodegradability and compatibility. By using the electrohydrodynamic atomization technique (electrospraying), precise control over microparticle characteristics like size, shape, and composition is achieved by adjusting parameters such as voltage, flow rate, and solution properties. In this research, microparticles made from Spirulina extract and PLA were created through electrospraying to act as microcarriers. Different formulations were tested, including 3% PLA and blends of Spirulina extract and PLA at concentrations of 0.125%, 0.25%, and 0.5% using chloroform and ethanol in the ratio of 19:1. Through various tests (MTT assay and colony formation test) the biocompatibility of producing microparticles was assessed using HUVEC and HaCaT cell lines, indicating these microparticles' potential for diverse applications as microcarrier systems.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development, optimization, and characterization of microbially triggered Mimosa pudica gum-chitosan polyelectrolyte complex for colon-targeted drug delivery. 微生物触发的含羞草胶-壳聚糖多电解质复合物结肠靶向给药的开发、优化和表征。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-26 DOI: 10.1080/09205063.2025.2504711

Samridhi Kurl, Gurpreet Kaur

{"title":"Development, optimization, and characterization of microbially triggered Mimosa pudica gum-chitosan polyelectrolyte complex for colon-targeted drug delivery.","authors":"Samridhi Kurl, Gurpreet Kaur","doi":"10.1080/09205063.2025.2504711","DOIUrl":"https://doi.org/10.1080/09205063.2025.2504711","url":null,"abstract":"This study aimed to develop a novel polymeric complex composed of Mimosa pudica gum (MMG) and chitosan (CH) and to explore its potential as a delivery system for targeting drugs to the colon. The method of extraction of MMG was optimized, resulting in a maximum yield of 12.41%. The molecular weight of the gum was determined to be 5.07 × 106 Da, and it was characterized for its physicochemical and rheological properties. A species distribution profile was constructed using the pKa values of both polymers, and polyelectrolyte complexes (PECs) were prepared at a pH value of 5.25 ± 0.10. The 40:60 (MMG: CH) PECs exhibited the highest yield (99%), minimal viscosity, and near-neutral zeta potential. Microflora biodegradation studies of PECs in pH 6.8 buffer containing rat cecal contents showed a pH decrease, likely due to degradation products of the PECs. In vitro drug release studies revealed 16.6% capecitabine release (model drug) from PECs without rat cecal contents, compared to 88.5% release after 24h with rat cecal contents. These findings suggest that MMG-CH PECs could serve as promising vehicles for microbially triggered, colon-targeted drug delivery systems.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral natural material hydrogels: a new strategy for enhancing oral drug delivery efficiency. 口服天然材料水凝胶：提高口服给药效率的新策略。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-26 DOI: 10.1080/09205063.2025.2509028

Qi Yang, Xi Xiang, Han Wang, Yue Liao, Xinzhi Li

{"title":"Oral natural material hydrogels: a new strategy for enhancing oral drug delivery efficiency.","authors":"Qi Yang, Xi Xiang, Han Wang, Yue Liao, Xinzhi Li","doi":"10.1080/09205063.2025.2509028","DOIUrl":"https://doi.org/10.1080/09205063.2025.2509028","url":null,"abstract":"Oral administration, owing to its high patient compliance and favorable controllability, is widely employed in clinical settings; however, the efficacy is often constrained by the gastrointestinal environment's impact on bioavailability. As the demand for biocompatibility and biodegradability in biomedical applications intensifies, natural hydrogel-based oral drug delivery systems have gained substantial attention as promising carriers. In this study, we introduce a variety of natural materials, revealing their advantages in enhancing drug bioavailability and targeting capabilities. Through both physical and chemical crosslinking mechanisms, we successfully demonstrate hydrogels exhibiting excellent mechanical properties and biocompatibility. Furthermore, we analyze the potential applications of diverse natural oral hydrogels across fields such as gastrointestinal, metabolic, oncological, and immunotherapeutic diseases. By synthesizing recent advances in this area, we aim to elucidate the critical role these systems can play in biomedicine. Our findings suggest that natural materials possess broad prospects in drug delivery, advocating for continued exploration of their clinical application to facilitate the development and optimization of novel oral therapeutic modalities. This work provides a vital theoretical foundation and practical guidance for future innovations in drug delivery technologies.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-28"},"PeriodicalIF":3.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of carob honey loaded chitosan nanoparticles and determination of its antimicrobial potential and cytotoxic effect on breast cancer cell line. 角豆蜜负载壳聚糖纳米颗粒的合成及其抑菌潜能和对乳腺癌细胞毒作用的测定。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-24 DOI: 10.1080/09205063.2025.2505702

Bashir Ahmad, Erkay Özgör, Doga Kavaz, Ahmad Shehu

{"title":"Synthesis of carob honey loaded chitosan nanoparticles and determination of its antimicrobial potential and cytotoxic effect on breast cancer cell line.","authors":"Bashir Ahmad, Erkay Özgör, Doga Kavaz, Ahmad Shehu","doi":"10.1080/09205063.2025.2505702","DOIUrl":"https://doi.org/10.1080/09205063.2025.2505702","url":null,"abstract":"Embedding natural products into chitosan nanoparticles (CNP) is an effective way to produce a novel combination with better antimicrobial and anticancer activities. Therefore, this study aims to incorporate carob honey (CH) into CNP, determine its potential antimicrobial along with antiproliferative activities, by well diffusion and MTT cell viability assays, respectively. Successful loading of CH in CNP was confirmed after due characterization. The nanoparticles, synthesized by ionic gelation method, produced a small (101.3 ± 4.13 nm), stable (+27.27 ± 0.95 mV), and monodispersed (0.2265 ± 0.0027) CH-loaded CNP (CHCNP). The best antibacterial activity occurred in Klebsiella pneumoniae (K. pneumoniae) (23 ± 0 mm to 16 ± 1.7 mm) followed by Escherichia coli (E. coli) (18 ± 2.0 mm to 10 ± 1 mm). Meanwhile, Aspergillus niger (A. niger) and Aspergillus flavus (A. flavus) were evenly inhibited with inhibition zones in the range of 15 ± 3 mm to 7 ± 0.8 mm and 15 ± 5 mm to 9 ± 1.4 mm, respectively. CHCNP showed a remarkable cytotoxic effect on MDA-MB-231 according to concentration and time, with IC50 of 25 ± 5 to 18 ± 2.6 μg/mL within 24-72 h. These findings demonstrated the feasibility of loading CH in CNP to form a nanoformulation that could potentially serve as a target-specific therapeutic agent in the treatments of microbial infections and breast cancer. However, there is a need for further research on the safety, dosage optimization, in vivo studies and mechanisms of action of the nanoparticles.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-21"},"PeriodicalIF":3.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0