Journal of Biomaterials Science, Polymer Edition最新文献_第4页

Developing antioxidant-antimicrobial nanofibers containing Corallina officinalis extract for wound healing. 含有珊瑚提取物的抗氧化-抗菌纳米纤维用于伤口愈合。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-31 DOI: 10.1080/09205063.2025.2537744

Ahmed Mostafa Fahmy, Amel M Soliman, Sohair R Fahmy, Sara Bayoumi Ali, Shimaa A Sadek

{"title":"Developing antioxidant-antimicrobial nanofibers containing Corallina officinalis extract for wound healing.","authors":"Ahmed Mostafa Fahmy, Amel M Soliman, Sohair R Fahmy, Sara Bayoumi Ali, Shimaa A Sadek","doi":"10.1080/09205063.2025.2537744","DOIUrl":"10.1080/09205063.2025.2537744","url":null,"abstract":"The growing global demand for wound care has revealed the limitations of traditional dressings, particularly their insufficient antimicrobial and antioxidant properties. This study aims to develop a natural-based nanofibrous dressing that improves wound dressing effectiveness by addressing challenges such as antimicrobial activity and moisture regulation. The research focuses on developing antimicrobial and antioxidant mats using chitosan, polyvinyl alcohol (PVA), and crude Corallina officinalis extract (COE) via electrospinning. A comprehensive evaluation assessed their morphology, structure, mechanical properties, wettability, biodegradation rate, and biological activities. FTIR spectroscopy confirmed the integration of all components, while SEM analysis showed bead-free nanofibers with a diameter of 230 ± 5.57 nm, significantly enhancing mechanical strength from 6.62 ± 0.04 MPa to 7.34 ± 0.03 MPa. Adding 3% COE preserved ideal hydrophilicity, biodegradation rates, and swelling index for tissue regeneration. Antibacterial tests showed a zone of inhibition measuring 28.00 ± 0.10 mm against Escherichia coli and 22.00 ± 0.20 mm against Staphylococcus aureus when using a 3% concentration of COE. Additionally, the fabricated dressings effectively prevented bacterial penetration, resulting in negligible colony growth in the culture media. The present study demonstrated that nanofiber dressings significantly enhance the biological activities of COE, particularly its antioxidant and anti-inflammatory effects. Moreover, the COE and CS/PVA/COE nanofiber mats exhibit excellent biocompatibility and low cytotoxicity, promoting skin cell survival and proliferation. So, this research highlights the promising potential of COE-enriched nanofibers in advanced wound care applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-39"},"PeriodicalIF":3.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the influence of human serum albumin on the degradation behavior of PLA films produced with green solvent. 解码人血清白蛋白对绿色溶剂制备的聚乳酸薄膜降解行为的影响。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-27 DOI: 10.1080/09205063.2025.2535736

Ester Escalera-Rota, Margarita Hierro-Oliva, M Luisa González-Martín, Amparo María Gallardo-Moreno

{"title":"Decoding the influence of human serum albumin on the degradation behavior of PLA films produced with green solvent.","authors":"Ester Escalera-Rota, Margarita Hierro-Oliva, M Luisa González-Martín, Amparo María Gallardo-Moreno","doi":"10.1080/09205063.2025.2535736","DOIUrl":"https://doi.org/10.1080/09205063.2025.2535736","url":null,"abstract":"Polylactic acid (PLA) is gaining prominence in biomedical fields due to its favorable physicochemical characteristics, such as biodegradability and biocompatibility. This study investigates the degradation behavior of PLA films fabricated with dimethyl carbonate, a green solvent alternative to traditional chloroform, and sterilized via UV-C irradiation. Two degradation pathways were examined: exposure to ultraviolet radiation (photodegradation) and immersion in a simulated body fluid (m-SBF) buffer (physiodegradation), with and without human supplementation of serum albumin (HSA). Surface properties such as zeta potential, hydrophobicity, surface tension, and chemical composition were evaluated before and after degradation. Prolonged UV-C photodegradation resulted in chemical activation of the surface, which modulated subsequent interactions with the physiological environment. More specifically, an increase of the negative surface charge and a slight reduction of the surface free energy were observed. Photodegradation enhanced subsequent physiodegradation, as evidenced by greater surface polarity and ion adsorption. Immersion in m-SBF led to increased hydrophilicity, while HSA presence during immersion influenced the formation of biointerfacial layers, markedly shifting the surface to a superhydrophilic and nearly neutral electrical state. Analytical techniques such as time-of-flight secondary ion mass spectrometry identified the presence of nitrogen-containing fragments indicative of protein attachment. Notably, UV-C exposure reduced protein adsorption, suggesting changes in surface affinity.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on spinning methods of recombinant spidroins. 重组蛛丝纺丝方法的研究进展。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-27 DOI: 10.1080/09205063.2025.2534689

Tingting Zhang, Mengke Zhou

{"title":"Research progress on spinning methods of recombinant spidroins.","authors":"Tingting Zhang, Mengke Zhou","doi":"10.1080/09205063.2025.2534689","DOIUrl":"https://doi.org/10.1080/09205063.2025.2534689","url":null,"abstract":"Spider silk is a natural biomaterial that has attracted considerable attention because of its exceptional physical and chemical properties. Developing fiber materials that combine high strength and toughness remains a significant challenge, as increasing fiber strength often reduces toughness. However, spider silk achieves an optimal balance of these properties through gelation and stretching of its spinning solution. This remarkable feature has inspired extensive efforts to produce artificial fibers that mimic natural spider silk's materials, structures, and spinning mechanisms. For decades, researchers have focused on artificially spun recombinant spidroins to replicate the extraordinary mechanical properties of natural spider silk. This paper investigates the relationship between the structure and function of spidroins. It reviews the primary methods for synthesizing spider silk fibers, emphasizing their advantages and limitations. These insights provide a theoretical foundation for the design of artificial protein fibers and spinning equipment. This study addresses the challenges and unresolved issues in the current research. It proposes future directions, advancing our understanding of spidroins fiber production and establishing a foundation for further studies.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-25"},"PeriodicalIF":3.6,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parallel-Shaped poly(L-lactic acid) electrospun membrane promotes facial nerve injury regeneration by upregulating miR-451a expression. 平行形聚乳酸电纺丝膜通过上调miR-451a表达促进面神经损伤再生。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-27 DOI: 10.1080/09205063.2025.2532569

Mengdie Liu, Jian Wang, Yan Lv, Qiang Sun, Bin Guo

{"title":"Parallel-Shaped poly(L-lactic acid) electrospun membrane promotes facial nerve injury regeneration by upregulating miR-451a expression.","authors":"Mengdie Liu, Jian Wang, Yan Lv, Qiang Sun, Bin Guo","doi":"10.1080/09205063.2025.2532569","DOIUrl":"https://doi.org/10.1080/09205063.2025.2532569","url":null,"abstract":"Facial nerve injury (FNI) causes devastating sequelae, including impaired eyelid closure, dysphagia, and permanent facial asymmetry, leading to long-term functional deficits and profound psychosocial impacts that pose significant rehabilitation challenges. To address this, neural regenerative scaffolds represent a promising therapeutic alternative. This study engineered poly(L-lactic acid) (PLLA) electrospun membranes with parallel topographical cues (Align) and functionalized miR-451a-incorporated scaffolds (miR-451a mimics@PLLA) via electrostatic spinning, aiming to decipher how topographical cues steer neurogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and their crosstalk with microRNA regulation. We demonstrate that parallel topography substantially upregulates neurulation-associated biomarkers (Tuj-1, S100, NeuroD1, Map2, and Nestin) in BMSCs, while miR-451a synergistically enhances this differentiation efficacy. The developed miR-451a mimics@PLLA scaffold effectively promotes BMSC neurogenic commitment and functional nerve regeneration, offering a novel biomimetic strategy to overcome FNI complications. This work pioneers synergistic integration of topological engineering and miRNA delivery for next-generation neural repair scaffolds.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-21"},"PeriodicalIF":3.6,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Puerarin and dextran complex alleviates heat stress-induced hippocampal apoptosis and oxidative damage: therapeutic potential for hypothalamic neuronal damage in mice. 葛根素和葡聚糖复合物减轻热应激诱导的海马细胞凋亡和氧化损伤：对小鼠下丘脑神经元损伤的治疗潜力。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-24 DOI: 10.1080/09205063.2025.2506925

Biyue Zhang, Weiwei Li, Yutang Wu, Chunzhan Hong, Shitu Zhuo, Miao Yu, Zeming Guo, Huasong Lin, Lichao Ye, Zhenwu Zhao

{"title":"Puerarin and dextran complex alleviates heat stress-induced hippocampal apoptosis and oxidative damage: therapeutic potential for hypothalamic neuronal damage in mice.","authors":"Biyue Zhang, Weiwei Li, Yutang Wu, Chunzhan Hong, Shitu Zhuo, Miao Yu, Zeming Guo, Huasong Lin, Lichao Ye, Zhenwu Zhao","doi":"10.1080/09205063.2025.2506925","DOIUrl":"https://doi.org/10.1080/09205063.2025.2506925","url":null,"abstract":"Puerarin (Pn), a naturally occurring flavonoid, possesses numerous therapeutic qualities, while Dextran (Dn) is a naturally derived polysaccharide. Here, we examined the puerarin-dextran complex (Pn/Dn), characterization to confirming its functional groups through morphological and structural properties. Cytocompatibility assessments on HT22 cell lines along with ROS and MDA content analysis revealed higher cytocompatibility with Pn/Dn complex treatment, when compared to heat-stressed and control groups. Additionally, elevated oxidative stress levels were found to reduce after treatment with Pn/Dn complex. Flow cytometry analysis demonstrated that HT22 cells treated with puerarin, dextran, and the Pn/Dn complex exhibited preserved viability, with a reduced percentage of cells undergoing early and late apoptosis, particularly at concentrations below 20%, indicating effective prevention of cell death. Importantly, In vivo results proposed that neuronal death in various histopathological observations involves both neurons and surrounding glial cells. These findings demonstrate that the Pn/Dn complex effectively influenced in reduced hippocampal neuronal injury in mice, as confirmed by histological examination. Overall, this study highlights the protective effects of Pn/Dn complex against heat-induced neuronal injury and oxidative stress, emphasizing their potential therapeutic applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-19"},"PeriodicalIF":3.6,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissolvable microneedles based on active components of Chinese Herbal Medicine for enhanced treatment of skin diseases. 基于中草药活性成分的可溶解微针，用于增强治疗皮肤病。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-22 DOI: 10.1080/09205063.2025.2535492

Kai Ye, Ziyan Chen, Lan He, Huayi Wu, Zeyu Chen, Jing Tan

{"title":"Dissolvable microneedles based on active components of Chinese Herbal Medicine for enhanced treatment of skin diseases.","authors":"Kai Ye, Ziyan Chen, Lan He, Huayi Wu, Zeyu Chen, Jing Tan","doi":"10.1080/09205063.2025.2535492","DOIUrl":"https://doi.org/10.1080/09205063.2025.2535492","url":null,"abstract":"According to World Health Organization (WHO) estimates, around 900 million people globally are affected by various skin diseases, which cause significant physical and psychological distress and place a heavy economic burden on healthcare systems. The primary challenges in treating skin diseases include the limited transdermal drug absorption due to the skin barrier, the side effects associated with medications, and the recurring nature of these conditions that lead to prolonged patient suffering. Microneedles (MNs) have emerged as a promising transdermal drug delivery technology, able to painlessly penetrate the stratum corneum and deliver medications directly to the affected area. Various types of MNs technology have been developed, including dissolvable MNs (DMNs), solid MNs, coated MNs, hollow MNs, and hydrogel-based MNs. DMNs, especially, offer non-invasive drug delivery with sustained release through their dissolvable nature. Combining active ingredients from Chinese Herbal Medicine (CHM), known for their natural anti-inflammatory and antibacterial properties with minimal side effects, with DMNs provides an effective approach for treating skin diseases. This review aims to provide a comprehensive overview of the application of CHM-based DMNs in treating psoriasis, acne, hypertrophic scars, keloids, melanoma, atopic dermatitis, and other skin conditions. Additionally, it will introduce the manufacturing methods for CHM-based DMNs, explore strategies for integrating CHM with MNs, and summarize the broad translational potential and challenges of this technology in the field of dermatology.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-25"},"PeriodicalIF":3.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A microphysiological systems approach to design gastrointestinal system. 用微生理系统方法设计胃肠系统。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-21 DOI: 10.1080/09205063.2025.2532567

Vidhi Mathur, Mrunmayi Gadre, Amrutha H K, Kirthanashri S Vasanthan

{"title":"A microphysiological systems approach to design gastrointestinal system.","authors":"Vidhi Mathur, Mrunmayi Gadre, Amrutha H K, Kirthanashri S Vasanthan","doi":"10.1080/09205063.2025.2532567","DOIUrl":"https://doi.org/10.1080/09205063.2025.2532567","url":null,"abstract":"The gastrointestinal (GI) system is a complex and dynamic organ system, with the anatomy and varied physiological functionality adding complexity to nutrient absorption, immune function, and maintenance of overall health. This review begins with an overview of the anatomy, highlighting key organs and their respective roles, followed by an exploration of the functionality and physiology, detailing mechanisms of digestion, and microbial interactions. Traditional in vitro models and animal studies often fall short in accurately replicating the intricate environment of the human gut. Microphysiological systems (MPS) offer innovative solutions, integrating advanced techniques such as 3D bioprinting, spheroids, organoids, and microfluidics to create more accurate and dynamic models and have emerged as promising solutions to bridge this gap. This paper delves into the applications of MPS in the context of the GI system, including 3D bioprinted models that provide structural fidelity, intestinal organoids that mimic cellular complexity, and gut-on-chip devices that recreate the physiological environment. The transformative potential of MPS in overcoming the limitations of conventional models and accelerating biomedical research and therapeutic development in the GI domain is being well studied. These cutting-edge technologies hold promise for enhancing our understanding of GI biology, improving drug testing, and advancing personalized medicine.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-42"},"PeriodicalIF":3.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-modified gelatin hydrogel scaffolds with imprinted microgrooves: physical characterization and study on endothelial cell interaction. 带有印迹微沟槽的表面改性明胶水凝胶支架：物理表征及内皮细胞相互作用的研究。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-20 DOI: 10.1080/09205063.2025.2527912

Ali Salehi, Lena Rutz, Konstantin Ulbrich, Johanna Stevens, Markus Guttmann, Matthias Worgull, Giorgio Cattaneo

{"title":"Surface-modified gelatin hydrogel scaffolds with imprinted microgrooves: physical characterization and study on endothelial cell interaction.","authors":"Ali Salehi, Lena Rutz, Konstantin Ulbrich, Johanna Stevens, Markus Guttmann, Matthias Worgull, Giorgio Cattaneo","doi":"10.1080/09205063.2025.2527912","DOIUrl":"https://doi.org/10.1080/09205063.2025.2527912","url":null,"abstract":"Endothelialization of biomaterials enhances biocompatibility, hemocompatibility, and reduces inflammatory responses in blood-contacting materials. Surface topographies, particularly groove-like structures, influence endothelial cell morphology and function. This study investigates the impact of microgroove dimensions on endothelialization in gelatin hydrogel scaffolds, alongside assessing their physical and mechanical properties. Using sequential replications, six microgroove geometries with widths ranging from 2.86 µm to 84.20 µm and depths from 284 nm to 919 nm were fabricated on gelatin hydrogel. Surface characterization of the scaffolds over 5 days using confocal microscopy revealed a shrinkage followed by dimensional stability after 24 h. Tensile testing after conditioning in cell culture environments showed Young's modulus of 327.2-529.5 kPa comparable to natural blood vessels. Cultivation of human endothelial cells demonstrated improved cell orientation and elongation on microstructured surfaces. Notably, two specific microgrooved scaffolds (9.33 µm width, 599 nm depth and 22.27 µm width, 919 nm depth) enhanced cell proliferation, adhesion and accelerated confluent monolayer formation as confirmed through fluorescent staining for cell nuclei, Vinculin, and VE-cadherin expression, respectively. This study identifies optimal microgroove dimensions for surface modification of gelatin hydrogel scaffolds demonstrating how geometric cues can positively impact cell morphology and function. This surface engineering approach has a potential application in in vitro endothelialized models for cardiovascular research as well as in vascular implants for tissue remodeling.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-36"},"PeriodicalIF":3.6,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in nanotechnology for PARP inhibitor delivery: a comprehensive review of diverse nanosystems, their mechanisms, and therapeutic applications across cancer and beyond. 纳米技术在PARP抑制剂递送中的进展：各种纳米系统、它们的机制以及在癌症和其他领域的治疗应用的综合综述。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-18 DOI: 10.1080/09205063.2025.2534698

Bassam M Abualsoud, Majid Alhomrani, Abdulhakeem S Alamri, Walaa F Alsanie, Suhas Ballal, Girish Chandra Sharma, T Krithiga, Abhayveer Singh, Arun Kumar, Deepak A

{"title":"Advancements in nanotechnology for PARP inhibitor delivery: a comprehensive review of diverse nanosystems, their mechanisms, and therapeutic applications across cancer and beyond.","authors":"Bassam M Abualsoud, Majid Alhomrani, Abdulhakeem S Alamri, Walaa F Alsanie, Suhas Ballal, Girish Chandra Sharma, T Krithiga, Abhayveer Singh, Arun Kumar, Deepak A","doi":"10.1080/09205063.2025.2534698","DOIUrl":"https://doi.org/10.1080/09205063.2025.2534698","url":null,"abstract":"Poly (ADP-ribose) polymerase (PARP) inhibitors have appeared as a transformative class of anticancer agents, particularly for tumors with homologous recombination deficiencies such as BRCA1/2-mutated breast, ovarian, prostate, and pancreatic cancers. Despite their clinical success, challenges such as poor bioavailability, systemic toxicity, and acquired resistance have limited their broader application. Nanotechnology-based drug delivery systems offer a promising strategy to overcome these limitations by enhancing the solubility, stability, and tumor-specific accumulation of PARP inhibitors while reducing off-target effects. This review explores the mechanism of action of PARP inhibitors, including their role in DNA repair and synthetic lethality, and discusses their therapeutic applications. Furthermore, recent progresses in delivery systems, including lipid-based, polymeric, inorganic, and hybrid nanosystems, are examined with a focus on their design, functionality, and impact on drug efficacy. Recent studies demonstrating improved drug retention, enhanced tumor targeting, and controlled release mechanisms are highl'hted, along with potential strategies to overcome resistance. The integration of multifunctional and stimuli-responsive nanosystems further enhances the therapeutic potential of PARP inhibitors. Continued innovation in nanomedicine holds the potential to optimize PARP inhibitor therapy and expand its clinical utility in personalized cancer treatment. Future directions include addressing translational challenges, scalability, and regulatory considerations for clinical applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-62"},"PeriodicalIF":3.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic evaluation of anti-diabetic and hypolipidemic effects of Alangium salvifolium and Ocimum sanctum extracts. 丹参提取物和麝香提取物降糖降血脂的协同作用评价。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-14 DOI: 10.1080/09205063.2025.2527254

Deepak Jain, Pankaj Sharma, Vinay Jain

{"title":"Synergistic evaluation of anti-diabetic and hypolipidemic effects of Alangium salvifolium and Ocimum sanctum extracts.","authors":"Deepak Jain, Pankaj Sharma, Vinay Jain","doi":"10.1080/09205063.2025.2527254","DOIUrl":"https://doi.org/10.1080/09205063.2025.2527254","url":null,"abstract":"In this study, Alangium salvifolium and Ocimum sanctum extracts were investigated for their antioxidant, antidiabetic and hypolipidemic activities individually and in combined form. HPLC, LC-MS and UPLC phytochemicals profiling identified phenolics and flavonoids as major bioactives. Antioxidant assays showed significant DPPH and ABTS radical scavenging activities, with the combined formulation (1:1 ratio) 91.2 and 89.6% inhibition was achieved respectively. Antidiabetic activities were first investigated in vitro with the ability of the combination to inhibit both α-amylase (IC50 = 38.4 µg/mL) and α-glucosidase (IC50 = 45.2 µg/mL) having the strongest inhibitory effects. The hypolipidemic activity included inhibition of lipid peroxidation (78.5%); pancreatic lipase inhibition (70.2%). The bioactives were further molecular docked to find strong binding affinities with PPARγ, DPP-IV, and HMG-CoA reductase. Results were confirmed statistically different (p < 0.05) between treated and control groups. These results suggest that the extracts can exhibit synergy as natural therapeutics in diabetes and lipid disorders.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-29"},"PeriodicalIF":3.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0