Journal of Biomaterials Science, Polymer Edition最新文献

{"title":"Polymer for advanced wound healing: design and mechanism.","authors":"Xiaodan Zhang, Qing Zhang, Chaoxian Chen","doi":"10.1080/09205063.2025.2591271","DOIUrl":"10.1080/09205063.2025.2591271","url":null,"abstract":"<p><p>Smart and rapid wound healing has long been a significant challenge for the medical community. Recent advancements in biomaterials and manufacturing technologies are overcoming the limitations of traditional wound dressings. Notably, reversible light-responsive azobenzene derivatives in elastomer form are emerging as intelligent materials for this purpose. Their reversible photoisomerization properties have extensive applications in wound healing. This study systematically reviews the design principles, strategies, and mechanisms of smart elastomers based on drugs, as well as their applications in various stages of wound healing. When classifying drugs-releasing elastomers by response factors and loaded drugs, we emphasize design strategies based on physical blending and temperature or light microenvironments. Comparing smart elastomers to traditional polymer dressings, this review highlights how the dual presence of photoisomerization and dynamic bonds grants these polymers non-contact, reversible, intelligent adhesive properties. This unique combination enhances drugs delivery efficiency at wound sites while minimizing patient discomfort. The review discusses the advantages, challenges, and future prospects of smart elastomers in wound healing, offering new insights into intelligent drugs delivery systems for wound treatment.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2585-2618"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-encapsulation of bromelain and doxorubicin in acid-responsive nanogels for enhanced chemotherapy via tumor ECM degradation.","authors":"Lijun Wang, Miao Lei, Jie Hao, Xiaojun Zhang, Wei Jiang, Zhenming Hu","doi":"10.1080/09205063.2025.2599287","DOIUrl":"10.1080/09205063.2025.2599287","url":null,"abstract":"<p><p>The therapeutic efficacy of chemotherapy in solid tumors such as osteosarcoma is hindered by the dense, collagen-rich extracellular matrix (ECM). In this work, we report an acid-responsive nanogel that co-encapsulates bromelain (BL), a proteolytic enzyme, and doxorubicin (DOX) with spatially distinct localization and independent pH-responsive release mechanisms. BL is encapsulated within the nanogel network, whereas DOX is covalently grafted onto the nanogel surface <i>via</i> an acid-labile linker, enabling the nanocarrier (ng(BL-DOX)) to remain stable under physiological conditions while promoting controlled release in the mildly acidic tumor microenvironment. The released BL degrades collagenous ECM components and reduces matrix density, thereby improving the penetration and intratumoral distribution of the concurrently released DOX. In a murine osteosarcoma model, the PEG-rich nanogels showed prolonged circulation and increased tumor accumulation <i>via</i> the enhanced permeability and retention (EPR) effect, accompanied by collagen I degradation and effective tumor growth inhibition, with final tumor volumes reduced to approximately one-tenth of those in the control group and without observable systemic toxicity. This microencapsulation approach provides an enzyme-drug co- encapsulation system that combines ECM degradation with chemotherapy in a single nanogel platform and may be adapted to other proteolytic enzymes and cytotoxic agents for the treatment of stroma-rich solid tumors.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2567-2584"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astragaloside-loaded PCL microspheres prepared from microchips for promoting collagen regenerating.","authors":"Die Xie, Xin Che, Li Zha, Qian Zhang, Mengxing Chen, Lihong Wang","doi":"10.1080/09205063.2025.2604821","DOIUrl":"10.1080/09205063.2025.2604821","url":null,"abstract":"<p><p>Polycaprolactone (PCL) microspheres are effective in stimulating collagen regeneration. However, the local inflammation they induce upon subcutaneous injection, particularly during the initial post-injection phase, cannot be overlooked. In this study, we designed and fabricated Astragaloside (AS)-loaded PCL microspheres using microfluidic technology for subcutaneous injection to promote collagen regeneration. The incorporation of AS and the application of microfluidic technology endowed the AS/PCL microspheres with a significantly reduced incidence of initial inflammation, thereby enhancing their safety profile. We prepared the AS/PCL microspheres <i>via</i> microfluidic technology and conducted characterization alongside <i>in vitro</i> and <i>in vivo</i> studies. Results demonstrated that the AS/PCL microspheres exhibited a circularity index of 0.90 ± 0.03, an average particle size of 30.45 ± 5.49 μm, and the polydispersity index (PDI) was 0.26 ± 0.03. The AS/PCL microspheres significantly enhanced the proliferation and migration of L929 fibroblasts. <i>In vivo</i> pharmacodynamic studies revealed that the inclusion of AS effectively mitigated the initial inflammatory response triggered by PCL microspheres and promoted superior collagen regeneration. Consequently, the microfluidically fabricated AS/PCL microspheres developed in this study demonstrate enhanced safety and efficacy for subcutaneous injection in promoting collagen regeneration.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2794-2812"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145810030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical-incorporated 3D-printed polylactic acid-starch composite scaffolds for localised breast cancer therapy: fabrication, physicochemical characterisation, and preliminary biological evaluation.","authors":"Jeswin Anto L, Kaviya Sri R, Anandakumar Srinivasan, Vaibhav Srivastava","doi":"10.1080/09205063.2026.2741659","DOIUrl":"https://doi.org/10.1080/09205063.2026.2741659","url":null,"abstract":"<p><p>Recurrence of locoregional tumours after breast-conserving surgery presents a considerable obstacle, underscoring the necessity for targeted treatment approaches that minimise systemic exposure. This research involved the creation of a biodegradable, dual-purpose scaffold by integrating <i>Momordica charantia</i> ethanol extract (BME) into a 3D-printed polylactic acid-starch (PLA-starch) composite produced by fused deposition modelling (FDM). The scaffold underwent a thorough assessment of its physicochemical properties, mechanical performance, phytochemical incorporation, release dynamics, and initial biological efficacy. Spectroscopic and diffraction examinations corroborated the connections between BME and the polymer matrix, whilst morphological and thermal assessments indicated effective integration without undermining the structural integrity necessary for processing. The loading of BME was evaluated independently by UV-Vis spectrophotometry and HPLC, revealing a strong correlation between the two methods. The BME-impregnated scaffold demonstrated decreased compressive rigidity and a biphasic release pattern, with kinetic evaluation suggesting diffusion-related release characteristics. GC-MS analysis disclosed a varied phytochemical profile of BME. Significantly, scaffold-released BME exhibited lethal effects against MCF-7 and MDA-MB-231 breast cancer cells in a concentration-dependent manner, while preserving relatively good viability in Vero cells. The scaffold also shown antibacterial properties against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. These results confirm the PLA-starch-BME scaffold as a viable proof-of-concept system for localised phytochemical administration, but more release studies, mechanistic analyses, and <i>in vivo</i> assessments are necessary to validate its therapeutic potential.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-18"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of <i>in vitro</i> antioxidant activity of chrysin and <i>in vivo</i> wound healing potential of an optimized chrysin emulgel formulation.","authors":"Neha Singh, Phool Chandra","doi":"10.1080/09205063.2025.2603346","DOIUrl":"10.1080/09205063.2025.2603346","url":null,"abstract":"<p><p>The present study evaluated the <i>in vivo</i> wound healing activity of an optimized chrysin emulgel formulation. Antioxidant potential was confirmed through ferrous ion chelation and DPPH radical scavenging assays, showing dose-dependent activity with IC₅₀ values of 1755.78 µg/ml and 141.68 µg/ml, respectively. Acute dermal toxicity testing (OECD Guideline 402) revealed no signs of dermal or systemic toxicity at 2000 mg/kg. Wound healing efficacy was assessed using incision and excision models in Wistar albino rats, with animals divided into control (emulgel base), standard (1% silver sulfadiazine), and test (chrysin emulgel) groups. In the incision model, the test group achieved a tensile strength of 561.17 ± 1.11 g, comparable to the standard (565.33 ± 0.88 g). In the excision model, the chrysin emulgel achieved 97.93% wound contraction by day 12 with an epithelization period of 14.83 ± 0.30 days, similar to the standard (98.17%; 14.33 ± 0.42 days). Overall, the optimized chrysin emulgel demonstrated strong antioxidant activity, effective wound healing, and excellent safety, suggesting its potential as a natural alternative to silver sulfadiazine for topical wound management.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2748-2763"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanogenetics in diabetes: converging nanoscale platforms and gene modulation for metabolic reprogramming.","authors":"Ruchi Tiwari, Patibandla Jahnavi, Gurinderdeep Singh, Piyali Dey, Farhad F Mehta, Tirthankar Choudhury, Kamal Y Thajudeen, A K Bhandari, Pankaj Sharma","doi":"10.1080/09205063.2025.2591372","DOIUrl":"10.1080/09205063.2025.2591372","url":null,"abstract":"<p><p>Diabetes is still a global health crisis characterized by progressive dysfunction of the β-cells, insulin resistance and metabolic dysregulation. Classical pharmacotherapies have the benefit of symptomatic control without long-term metabolic reprogramming. The convergence of nanotechnology and gene modulation- here termed nanogenetics- a precise, durable way to reprogram glucose-homeostasis pathways. This critical review outlines the mechanistic foundations of nanogenetic interventions in the β-cells, hepatocytes, adipose tissue, and immune-metabolic interfaces. We offer an advanced taxonomy of nanoscale platforms (lipid, polymeric, inorganic, exosomal, and stimuli-responsive carriers) in combination with gene-editing modalities (RNA interference, CRISPR, epigenome editing, and synthetic gene circuits). The mapping of translational pipelines between <i>In vitro</i> organoids and humanized models to current clinical trials is done keeping in mind delivery issues, safety, manufacturing requirements and ethical aspects. Mechanistic insights are further improved with multi-omics profiling, high-end imaging, and computational digital twins. Through technological innovations and translational breakthroughs, a procession of nanogenetics-based long-term remission- and, eventually, curative interventions against diabetes is outlined.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2619-2670"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145604335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural amphiphilic co-polymers as sustainable nanocarriers for enhanced solubility of hydrophobic drugs.","authors":"Avnish Kumar, Anurag Verma, Gulshan Rathore","doi":"10.1080/09205063.2025.2597238","DOIUrl":"10.1080/09205063.2025.2597238","url":null,"abstract":"<p><p>A major barrier to effective therapy is the limited water solubility of many Biopharmaceutics Classification System (BCS) Class II and IV medications, which results in poor bioavailability and inconsistent patient outcomes. Better solubilization and stability are provided by traditional synthetic nanocarriers such as PLGA, poloxamers, and PEG-PLA; however, these have disadvantages such as toxicity, cost, reliance on petrochemical resources, and regulatory barriers. Natural amphiphilic co-polymers (NACPs) are a sustainable and amiable alternative to proteins, polysaccharides, and phospholipids. Because of their innate amphiphilicity, which promotes self-assembly into micelles, vesicles, nanogels, and hydrogels, hydrophobic drugs can be effectively encapsulated and released under controlled conditions.This review focuses on the structural foundations of amphiphilicity in graft and block copolymers, naturally occurring self-assembling systems, and chemically modified derivatives that enhance solubility and drug-polymer interactions. In contrast to synthetic carriers, NACPs have other benefits such as mucoadhesion, enzymatic degradability, pH/enzyme responsiveness, and generally recognized as safe (GRAS) regulatory status, even though problems with scalability, reproducibility, and long-term stability still exist. Their versatility includes oral, parenteral, transdermal, pulmonary, nasal, and ocular drug delivery, with notable improvements in solubility, bioavailability, and therapeutic accuracy. Recent advancements include stimuli-responsive designs, hybrid natural-synthetic systems, and artificial intelligence (AI)-driven modeling for predicting drug-polymer compatibility. Collectively, NACPs present a sustainable strategy for next-generation nanomedicine that strikes a balance between therapeutic efficacy and environmental responsibility. By addressing solubility concerns with environmentally acceptable carriers, NACPs have a substantial translational potential to promote pharmaceutical innovation and green drug delivery systems.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2695-2728"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of nanotechnology in bone repair: a critical review.","authors":"Afshin Teymouri, Mohammad Hossein Shahrezaee, Reza Heidari, Reza Mosaed, Mahdieh Soezi, Mostafa Shahrezaee, Mohsen Chamanara, Babak Jahangirifard","doi":"10.1080/09205063.2025.2604828","DOIUrl":"10.1080/09205063.2025.2604828","url":null,"abstract":"<p><p>Nanomaterials represent a promising class of biomaterials capable of mimicking natural bone morphology, thus helping to enable osseointegration during bone repair procedures, wherein the repair interfaces with surrounding bone. Owing to their nanoscale characteristics, these biomaterials are the primary candidates to replace missing bone. The main objective of the review is to investigate how nanomaterials may constitute innovative solutions for existing difficulties in bone repair strategies. The conventional methods often fail when faced with several major setbacks, such as inadequate cellular differentiation, insufficient osteogenic factor production, and poor mechanical properties in the process of bone regeneration, while nanomaterials can be used in creating bone tissue engineering scaffolds using novel techniques such as electrospinning and 3D bio-printing. Nanotechnology led to the creation of scaffolds that enhance bone regeneration through natural extracellular matrix-like mimicking, stimulate angiogenesis <i>via</i> controlled bioactive molecule delivery, and enhance tissue integration. Therefore, this review starts with nanomaterials and their importance and moves towards the role of nanomaterials in the design of bone tissue engineering scaffolds. Then, the important types of applied nanomaterials in bone tissue repair are discussed, and case studies are collected in this regard. In the following, the methods of manufacturing nanomaterial-based scaffolds are mentioned, and electrospinning and 3D printing are introduced as the most advanced approaches. Finally, the current challenges in preparing and producing nanomaterial scaffolds and future trends are discussed for use in bone tissue engineering.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2865-2893"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel drug-loaded nano-polymer comparison: amoxicillin between ceftriaxone for MCF-7 breast cancer cytotoxicity.","authors":"Khawla I Abd Nusaif, Bahaa K Al-Ghanimi, Zaid M Abbas, Mohammad N Al-Baiati","doi":"10.1080/09205063.2025.2599290","DOIUrl":"10.1080/09205063.2025.2599290","url":null,"abstract":"<p><p>The rising challenges of conventional chemotherapy, including drug resistance and systemic toxicity, necessitate the exploration of novel therapeutic strategies. Repurposing existing antibiotics offers a promising, cost-effective approach in oncology. In this study, we investigate the anticancer potential of two common β-lactam antibiotics, amoxicillin and ceftriaxone, by conjugating them to a novel glycerol-phthalic anhydride nano-polymer. Successful conjugation and nanoscale formulation (∼97 nm) were confirmed through FT-IR, NMR, and DLS. When evaluated against aggressive MCF-7 breast cancer cells, the ceftriaxone conjugate demonstrated superior efficacy, showing 14% greater cytotoxicity (IC₅₀ = 38.52 vs. 44.8 µg/mL) and inducing extensive apoptosis, evidenced by membrane blebbing and nuclear fragmentation. Molecular docking revealed a mechanistic basis for this enhanced activity, with ceftriaxone forming stronger binding interactions (-7.8 kcal/mol) with key breast cancer proteins, including π-sulfur and hydrogen bonds. This work establishes a scalable nano-polymer platform for antibiotic repurpose, identifies ceftriaxone as a superior candidate for breast cancer therapy, and provides a critical mechanistic bridge between drug chemistry and tumor biology. With its established clinical safety, this ceftriaxone-based system represents a viable candidate for rapid translation to <i>in vivo</i> studies.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2729-2747"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An overview of nanostructured lipid carriers containing phytoconstituents.","authors":"Snehal Nagpure, Shirish Jain, Subhash Deshmane","doi":"10.1080/09205063.2025.2592737","DOIUrl":"10.1080/09205063.2025.2592737","url":null,"abstract":"<p><p>The phytochemicals offer enormous therapeutic promise for treating a variety of illnesses, without serious side effects. Every country is resorting to self-medication in the form of herbal medicines in an effort to obtain healthcare beyond the conventional bounds of modern medicine. Bioavailability and site-specific targeting are the only factors that determine its effectiveness. Poor absorption rate of phytoconstituents is due to low lipid solubility, large molecular weight, and presence of multi-ring polyphenols in their structures. A combination of solid and liquid lipids in an appropriate ratio becomes nanostructured lipid carriers (NLCs) that overcomes the limitations of poor absorption. In this review, NLC containing various phytoconstituents are overviewed with special emphasis on methods of preparation, various examples of solid and liquid lipids and outcomes which improved absorptions, bioavailability, minimum particle size, appropriate polydispersibility index and entrapment efficiencies. So, to encourage their continued usage in the future, this study will give a synopsis of the present status of NLCs containing phytoconstituents, including their formulations, modern processes, and uses in oral drug administration.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"2671-2694"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}