Journal of Biomaterials Science, Polymer Edition最新文献

{"title":"Engineering single-layered poly(amidoamine) dendrimer microcapsules for enhanced cellular uptake.","authors":"Danqing Yu, Xiaoqiang Zhang, Jianmei Han, Xingjie Zan, Yan Guo, Xuyang Chen","doi":"10.1080/09205063.2025.2543942","DOIUrl":"https://doi.org/10.1080/09205063.2025.2543942","url":null,"abstract":"<p><p>Microcapsules are considered as one of the most promising drug carriers due to their exceptional characteristics. The cellular uptake of microcapsules is determined by physicochemical properties, yet comprehensive studies on thickness and shape effects are limited. In this study, we developed single-layered poly(amidoamine) (PAMAM) dendrimer microcapsules with tunable thicknesses and morphologies to systematically investigate their cellular internalization. By varying PAMAM generations (G2-G8), the wall thickness can be tuned within the range of 19.3-53.7 nm, while the microcapsule shapes can be determined by the distinct morphologies of the CaCO₃ templates (spherical, peanut-like, dumbbell-like). Cellular uptake studies in DC2.4 cells revealed significant thickness- and shape-dependent trends: among spherical microcapsules, OPC/PAMAM-G6 microcapsules with a thickness of 43.5 nm exhibited higher internalization efficiency than their counterparts, while among OPC/PAMAM-G6 microcapsules, dumbbell-like microcapsules outperformed spherical and peanut-like microcapsules. Notably, dumbbell-shaped microcapsules with negative surface charge (-11.8 mV) demonstrated superior biocompatibility and uptake kinetics. This study demonstrates the structural diversity and functional versatility of PAMAM microcapsules by utilizing oligomeric proanthocyanidins (OPC), proposing a simple and universal method for preparing polyphenol/polymer microcapsules that can be applied to practical drug delivery systems.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144846629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of injectable hydrogels for bone tissue engineering applications.","authors":"Gajanan Arbade, Sayali Chandekar, Nikita Shinde, Pradnya Salve, Shivaji Kashte","doi":"10.1080/09205063.2025.2545091","DOIUrl":"https://doi.org/10.1080/09205063.2025.2545091","url":null,"abstract":"<p><p>In recent years, biomaterial-based tissue engineering approaches have efficiently treated bone defects caused by extensive trauma, fractures, and diseases. The repair and restoration of normal function of such defective bone tissues is a prominent global clinical demand. Among the biomaterial scaffolds used in TE, injectable hydrogels have gained tremendous potential in bone tissue engineering (BTE) due to their favorable properties like high water content, biomimicking with natural extracellular matrix, controlled mechanical properties, minimal invasiveness, and ability to match irregular defects. The present review focuses on preparing injectable hydrogels, their types, properties, and applications, with special emphasis on BTE. Further, the synergistic effect of hydrogels with other biomaterials and cell-encapsulated hydrogels for BTE has been discussed. A final deliberation has been made to emphasize the prospects of injectable hydrogels and their implementation for critical defects.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.6,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of a moringa gum cross-linked pectin nanogel for antifungal and anticancer activities.","authors":"Deepak Ram, Sangeeta Kumari, Rohini Dharela, Ghanshyam S Chauhan","doi":"10.1080/09205063.2025.2537742","DOIUrl":"https://doi.org/10.1080/09205063.2025.2537742","url":null,"abstract":"<p><p>Moringa gum was grafted with pectin and silver to synthesize the nanogel composite (Ag-Mog-Pec) by a multi-step process, which was used for evaluating its swelling nature, anticancer activity and for enhancing the efficacy of antifungal medications. The average size of synthesized Ag-Mog-Pec was determined to be approximately 175.67 ± 0.88 nm. The synthesized nanogel was analyzed using Fourier Transform Infrared Spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), X-ray Diffraction (XRD) and Dynamic Light Scattering (DLS) to confirm successful synthesis and evaluate potential applications. The evaluation of swelling nature was performed to find out the water absorption capacity of the synthesized nanogel under two distinct thermal conditions (25 °C and 37 °C) and across the various pH levels (2.2, 4.2, 6.5, 7.4 and 8.2). The effectiveness of the synthesized nanogel against cancer was tested using the MTT assay, which showed IC₅₀ values of 13.12 and 18.79 μg/ml for the A549 and L929 cell lines, respectively. The antifungal investigations were performed on four distinct fungal strains, such as <i>Candida albicans, Candida parapsilosis, Trichophyton rubrum</i> and <i>Trichophyton violaceum</i>. The antifungal study revealed a more efficient inhibitory zone, particularly against <i>Candida albicans, Candida parapsilosis</i> and <i>Trichophyton rubrum,</i> with Itraconazole (a known antifungal drug) being used as a positive control.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-16"},"PeriodicalIF":3.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan quaternary ammonium salt-stabilized cerium oxide nanoparticles green-synthesized using <i>Thymus vulgaris</i> extract: multifunctional antibacterial, anticancer, and wound healing applications.","authors":"Samaneh Kamalipooya, Davood Nasrabadi, Hamid Abtahi, Morteza Golmohammadi, Shohreh Fahimirad","doi":"10.1080/09205063.2025.2528934","DOIUrl":"https://doi.org/10.1080/09205063.2025.2528934","url":null,"abstract":"<p><p>This study presents the synthesis and biological evaluation of chitosan quaternary ammonium salt-stabilized cerium oxide nanoparticles (CS/CeO₂NPs), green-synthesized using <i>Thymus vulgaris</i> (thyme) extract. Characterization through Fourier Transform Infrared Spectroscopy (FTIR), Field-Emission Scanning Electron Microscopy (FESEM), and X-ray Diffraction (XRD) revealed uniform spherical nanoparticles with an average size of 120 nm and crystalline structure with an average crystal size of 28.32 nm. The incorporation of thyme extract into the CS matrix was confirmed. Drug release studies exhibited a biphasic pattern, with a rapid initial release (75.41% in 3 h) followed by a sustained release, achieving 92.56% over 10 days. Antibacterial assays demonstrated dose-dependent efficacy against <i>Staphylococcus aureus</i>, with significant antibacterial activity at concentrations above 60 μg/mL. <i>In vitro</i> anticancer assays revealed potent cytotoxicity against breast cancer (MCF-7) and colon cancer (CT26) cell lines, with 50% inhibition in MCF-7 and over 80% inhibition in CT26 cells at 60 μg/mL. <i>In vivo</i> evaluations further highlighted the therapeutic potential of CS/CeO₂NPs. Wound-healing assays demonstrated accelerated wound closure and enhanced epithelial regeneration in CS/CeO₂NPs-treated rats. <i>In vivo</i> antibacterial assays showed significant bacterial load reduction, particularly against <i>S. aureus</i>, indicating effective infection control. Histological analysis confirmed improved tissue regeneration, reduced inflammation, and enhanced re-epithelialization in CSQ/CeO₂NPs-treated wounds, suggesting efficient wound healing. These results underscore the multi-functional therapeutic potential of CS/CeO₂NPs, highlighting their antibacterial, antioxidant, anticancer, and wound-healing properties. Further research is needed to optimize formulations and elucidate the mechanisms driving their biological activities for clinical applications.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-27"},"PeriodicalIF":3.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of pore geometry and size of scaffold type structures for cell culture.","authors":"Amit S Patil, Deepak Singh, Kiran Bhole, Kruti Jharbade","doi":"10.1080/09205063.2025.2542480","DOIUrl":"https://doi.org/10.1080/09205063.2025.2542480","url":null,"abstract":"<p><p>Biomedical scaffolds are essential for tissue engineering as they provide a structural framework for tissue regeneration. This study investigates the optimization of polylactic acid scaffolds' pore geometry, fabricated using fused deposition modeling, to enhance tissue regeneration. Computational fluid dynamics analysis determined the impact of side length and wall thickness on permeability and pressure drop, while mechanical testing assessed induced stress. Results indicate that a cubic pore geometry with a 1.0 mm side length and a 0.3 mm wall thickness yields a porosity of 53.96%. Specifically, permeability increases with decreasing wall thickness. The induced stress varies inversely with the wall thickness for all cubic geometries. The pore geometry significantly impacts nutrient and waste transport, as well as cell attachment. Optimizing pore geometry can improve nutrient supply and waste removal, directly affecting cell survival and tissue growth. This optimized design aims to maximize nutrient delivery, minimize pressure drop, and maintain structural integrity, thereby promoting cell proliferation and improving the effectiveness of biomedical scaffolds for tissue regeneration.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-32"},"PeriodicalIF":3.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming resistance: targeted nanomedicine solutions for cancer therapy.","authors":"Bhaveshkumar Patel, Ankur Vashi, Akhilesh Kumar Kuril, Praveen Kumar Subbappa, Ramakrishna Borra","doi":"10.1080/09205063.2025.2545089","DOIUrl":"https://doi.org/10.1080/09205063.2025.2545089","url":null,"abstract":"<p><p>Multidrug resistance (MDR), or tumor drug resistance, is still one of the most serious issues in the treatment of cancer, which directly affects the efficacy of cancer therapies and the survival of patients. This review focuses on describing how nanotechnology in medicine may help to address MDR and presents novel approaches that may revolutionize targeted cancer treatment. In this review, we discuss the potential of different types of nanoparticles, such as liposomes, polymeric nanoparticles and metallic nanoparticles for targeted delivery, and the use of these nanoparticles to kill tumor cells without damaging the normal cells. Further, we discuss emerging approaches, including RNA interference, CRISPR-Cas9 gene editing, and stimuli-responsive nanoparticles, all of which indicate future directions for MDR combat. Based on such developments, nanomedicine turns out to be a crucial handle in oncology, end-user for superior and refine style of managing cancer. This review establishes the imperative practicing of transdisciplinary integration in order to attain the optimum advancement of nanomedicine in combating MDR and enhancing the survival prognosis of different forms of cancer in patients all over the world.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-33"},"PeriodicalIF":3.6,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PVA-GO-Lip hydrogel loaded alendronate sodium: friction adaptation, controlled release, antibacterial and mineralization mechanism.","authors":"Guangru Zhang, Qianqian Sun, Guofa Zhang, Litao Wang, Xiaoqiu Cui, Mei Lv","doi":"10.1080/09205063.2025.2525505","DOIUrl":"https://doi.org/10.1080/09205063.2025.2525505","url":null,"abstract":"<p><p>This research developed an advanced polyvinyl alcohol (PVA) based hydrogel, which combines graphene oxide (GO) and liposome (Lip) to solve the key challenges in joint repair. PVA-GO-Lip composite material was prepared by freeze-thaw cycling, forming a composite structure with hydrogen bonding network and embedded Lip micro reservoir. This material has excellent mechanical properties (300% elongation, 4.2 kg load capacity) and self-healing properties through dynamic hydrogen bonding. Friction tests showed that compared to pure PVA, friction was reduced by 48% (coefficient: 0.11) due to GO enhanced hydration and Lip mediated boundary lubrication. The release of alendronate (ALN) follows Higuchi kinetics, with stable Lip release under mechanical stress (cumulative release 82.4%). GO has excellent antibacterial activity (inhibition rate > 98% against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>), while ALN promotes significant mineralization (calcium/phosphate content increased by 8-16 times). This composite material has excellent stability (degradation of 2.6% within 30 days), adjustable hydrophilicity (contact angle of 36.5°), and swelling ability (equilibrium ratio of 49.21%). This multifunctional hydrogel combines mechanical durability, adaptive lubrication, controlled drug delivery, antibacterial effect and osteogenic potential. It is a promising biomimetic solution for the treatment of osteoarthritis and cartilage regeneration, linking biomechanical properties with therapeutic functions.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-22"},"PeriodicalIF":3.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photothermal and antimicrobial properties of catechol-chitosan silver nanoparticles/esterified sodium alginate composite hydrogels.","authors":"Sirui Chen, Chengao Li, Yanhong Teng, Huiqiong Wei, Cuixia Lu, Hua Yang","doi":"10.1080/09205063.2025.2526292","DOIUrl":"https://doi.org/10.1080/09205063.2025.2526292","url":null,"abstract":"<p><p>This study focuses on the preparation and evaluation of a catechol-modified hydroxypropyl chitosan/silver nanoparticle/phenylboronic acid alginate composite hydrogel (C/S/A/P/P). Hydroxypropyl chitosan (HCS) was modified with 3,4-dihydroxybenzaldehyde (DBA) <i>via</i> Schiff base reaction to produce adhesive catechol-modified hydroxypropyl chitosan (CHCS). The mechanical properties and self-healing ability of the hydrogel were enhanced by grafting phenylboronic acid (PBA) onto sodium alginate (SA) to form SA-PBA. The incorporation of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) further improved the mechanical properties, water absorption, and moisture retention of the hydrogel. Silver ions were reduced to silver nanoparticles (AgNPs) by the reducing property of catechol and integrated into the hydrogel network, endowing it with antibacterial functionality. The C/S/A/P/P hydrogel exhibits excellent mechanical properties (tensile stress of 391.99 kPa and strain of 149.11%), photothermal properties, and antibacterial performance (inhibition rates of 95.1% against <i>Escherichia coli</i> and 64.3% against <i>Staphylococcus aureus</i>). This green preparation method offers a new approach for developing advanced wound dressings.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next-generation smart wound dressings: AI integration, biosensors, and electrospun nanofibers for chronic wound therapy.","authors":"Naveen Palani, Keren Celestina Mendonce, Rabiya Riffath Syed Altaf, Agilandeswari Mohan, Parthasarathy Surya, Monisha P, K Radhakrishnan, Vishnupriya Subramaniyan, Suriyaprakash Rajadesingu","doi":"10.1080/09205063.2025.2540362","DOIUrl":"https://doi.org/10.1080/09205063.2025.2540362","url":null,"abstract":"<p><p>Polymeric biomaterials, particularly electrospun nanofibers, are increasingly central to the development of advanced wound dressings capable of supporting tissue regeneration while enabling real-time physiological monitoring. Chronic wounds associated with diabetes, vascular diseases, and cancer require continuous and personalized management, prompting the convergence of electrospun polymeric scaffolds with wearable biosensors and artificial intelligence (AI). These next-generation smart wound dressings utilize biocompatible polymer matrices functionalized with responsive sensing elements to monitor pH, temperature, moisture, oxygen saturation, and inflammatory biomarkers <i>in situ</i>. Molecular-level interactions between polymeric components and biological tissues facilitate both therapeutic delivery and diagnostic functionality. AI, including deep and federated learning, enhances these systems by enabling data-driven prediction of healing trajectories and personalized interventions. Key advances in flexible electronics, self-powered systems, and closed-loop feedback mechanisms further enhance clinical applicability. However, challenges remain, including the biochemical stability of sensors in enzyme-rich environments, secure wireless communication, and the lack of standardized datasets and clinical validation frameworks. This review critically examines recent progress in AI-integrated polymeric wound care systems, emphasizing the design of functional polymeric scaffolds, biosensor-polymer interfaces, and future directions, including biosensor miniaturization, multi-omics data integration, and scalable cloud-based platforms. A collaborative roadmap is proposed to advance these intelligent biomaterial systems toward clinical translation in chronic wound care.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-51"},"PeriodicalIF":3.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of thermo-sensitive hydrogels based on the Diels-Alder reaction and study on their <i>in vivo</i> biosafety.","authors":"Kun Du, Tenglong Xu, YuXin Wang, Yanan Lu, Yanwei Hou, Yongli Shi, Xueyan Hou","doi":"10.1080/09205063.2025.2526156","DOIUrl":"https://doi.org/10.1080/09205063.2025.2526156","url":null,"abstract":"<p><p>The goal of this study is to develop a novel injectable hydrogel, referred to as PPMF, and evaluate its biosafety profile. The PPMF polymer, which serves as the gelation precursor, was synthesized through a redox radical polymerization and amidation process. The molecular structures of the synthesized polymers were thoroughly characterized using ¹H nuclear magnetic resonance (¹H NMR) and Fourier transform infrared spectroscopy (FTIR). The PPMF hydrogel was formed <i>via</i> Diels-Alder reactions between the PPMF polymer and four-arm polyethylene glycol maleimide (4-armed-PEG-Mal) cross-linkers. A comprehensive assessment was conducted to evaluate the hydrogel's injectability, swelling ratios, hematotoxicity, biodegradability, and overall biosafety. Both FTIR and ¹H NMR spectra confirmed the successful synthesis of the PPMF polymers. The results revealed that the PPMF hydrogel demonstrated remarkable injectability, favorable swelling ratios, and minimal <i>in vitro</i> cytotoxicity. Upon subcutaneous injection into Kunming mice, the PPMF hydrogel degraded and was absorbed within 25 days. Importantly, the PPMF hydrogel showed no significant physiological or pathological changes in the internal organs of the treated mice. No inflammatory responses were observed at the injection sites, and blood routine and biochemical tests further emphasized the hydrogel's excellent biocompatibility and safety. In conclusion, the PPMF hydrogel's outstanding biosafety and unique properties make it a promising candidate for a wide range of applications in biological fields.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-13"},"PeriodicalIF":3.6,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}