Journal of Biomaterials Science, Polymer Edition最新文献_第5页

Effect of the molar mass of chitosan and film casting solvents on the properties of chitosan films loaded with Mentha spicata essential oil for potential application as wound dressing. 壳聚糖摩尔质量和成膜溶剂对载入薄荷精油的壳聚糖薄膜性能的影响，该薄膜有望用作伤口敷料。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-08-21 DOI: 10.1080/09205063.2024.2390752

Fatima Zahra Gana, Yahia Harek, Nadia Aissaoui, Taib Nadjat, Sarra Abbad, Houria Rouabhi

{"title":"Effect of the molar mass of chitosan and film casting solvents on the properties of chitosan films loaded with Mentha spicata essential oil for potential application as wound dressing.","authors":"Fatima Zahra Gana, Yahia Harek, Nadia Aissaoui, Taib Nadjat, Sarra Abbad, Houria Rouabhi","doi":"10.1080/09205063.2024.2390752","DOIUrl":"10.1080/09205063.2024.2390752","url":null,"abstract":"Chitosan based films endowed with antibacterial features have witnessed remarkable progress as potential wound dressings. The current study aimed at appraising the effects of the molar mass of chitosan (MM) and the film casting acids on the properties of unplasticized chitosan films and plasticized MSO-embedded chitosan films in order to provide best suited film formulation as a potential candidate for wound dressing application. The prepared films were functionally characterized in terms of their qualitative assessment, thickness, density, swelling behavior, water vapor barrier, mechanical and antibacterial properties. Overall, all chitosan films displayed thickness lower than the human dermis even though thicker and denser films were produced with lactic acid. Assessment of the swelling behavior revealed that only high molar mass (HMM) chitosan films may be regarded as absorbent dressings. Moreover, unplasticized HMM lactate (HMM-LA) films furnished lower stiffness and higher percent strain break as compared to acetate films, due to the plasticizing effect of the remaining lactic acid as alluded by the FTIR analysis. Meanwhile, they provided suitable level of moisture and indicated substantial antibacterial activity against S. aureus and E. coli, the most commonly opportunistic bacteria found in infected skin wound. Plasticized chitosan films doped with MSO were significantly thicker and more permeable to water compared to unplasticized films. Furthermore, MSO significantly potentiate the antibacterial effect of chitosan-based films. Therefore, plasticized HMM-LA/MSO chitosan film flashing good swelling behavior, adequate WVTR and WVP, suitable mechanical properties and antibacterial performances substantiated to be a promising antibacterial dressing material for moderately exuding wounds.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical analysis of chitosan oligosaccharide revealed its usefulness in effective delivery of drugs. 壳聚糖寡糖的理化分析表明了它在有效给药方面的作用。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-08-21 DOI: 10.1080/09205063.2024.2392365

Shraddha Gupta, Dhakshinamoorthy Vasanth, Awanish Kumar

{"title":"Physicochemical analysis of chitosan oligosaccharide revealed its usefulness in effective delivery of drugs.","authors":"Shraddha Gupta, Dhakshinamoorthy Vasanth, Awanish Kumar","doi":"10.1080/09205063.2024.2392365","DOIUrl":"https://doi.org/10.1080/09205063.2024.2392365","url":null,"abstract":"Chitosan oligosaccharides are biopolymers with a wide range of potential applications in various fields. This biopolymer is diverse and promising, and current research is investigating its capabilities for improved drug delivery. As chitosan oligosaccharide has the potential to be used as a drug delivery option, the purpose of this study was to examine its physicochemical characteristics and its potential for drug delivery. In this study, the pharmacokinetic properties of chitosan oligosaccharide were studied through Insilco investigation, which revealed that it is an extremely soluble and effective drug delivery candidate because it does not inhibit CYP isoenzymes and has a log Kp of -12.10 cm/s. It belongs to toxicity class 6 for acute oral toxicity, with an average similarity of 87.5% and a prediction accuracy of 70.97%. Additionally, XRD peak analysis revealed that the material was amorphous, as the peak appeared at 2θ = 24.62°, indicating the absence of well-defined crystalline areas. This characteristic makes the material more suitable for customization in many applications such as drug delivery and tissue engineering. FTIR, SEM, and TGA analysis were performed to gain a better understanding. These findings also emphasize the distinctive qualities and benefits of the oligosaccharides in this domain. Application of chitosan oligosaccharides in the development of efficient drug delivery systems. In the future, it would be more effective, targeted, and safe, with potent therapeutic efficacy for drug delivery.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of bacterial cellulose/acrylic acid-based pH-responsive smart dressings by graft copolymerization method. 用接枝共聚法制备细菌纤维素/丙烯酸基 pH 值响应型智能敷料。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-08-20 DOI: 10.1080/09205063.2024.2389689

Wen Zhang, Xinyue Hu, Fei Jiang, Yirui Li, Wenhao Chen, Ting Zhou

{"title":"Preparation of bacterial cellulose/acrylic acid-based pH-responsive smart dressings by graft copolymerization method.","authors":"Wen Zhang, Xinyue Hu, Fei Jiang, Yirui Li, Wenhao Chen, Ting Zhou","doi":"10.1080/09205063.2024.2389689","DOIUrl":"https://doi.org/10.1080/09205063.2024.2389689","url":null,"abstract":"Conventional wound dressings used in trauma treatment have a single function and insufficient adaptability to the wound environment, making it difficult to meet the complex demands of the healing process. Stimuli-responsive hydrogels can respond specifically to the particular environment of the wound area and realize on-demand responsive release by loading active substances, which can effectively promote wound healing. In this paper, BC/PAA-pH responsive hydrogels (BPPRHs) were prepared by graft copolymerization of acrylic acid (AA) to the end of the molecular chain of bacterial cellulose (BC) network structure. Antibacterial pH-responsive 'smart' dressings were prepared by loading curcumin (Cur) onto the hydrogels. Surface morphology, chemical groups, crystallinity, rheological, and mechanical properties of BPPRHs were analyzed by different characterization methods. The drug release behavior under different physiological conditions and bacteriostatic properties of BPPRH-Cur dressings were also investigated. The results of structural characterization and performance studies show that the hydrogel has a three-dimensional mesh structure and can respond to wound pH in a 'smart' drug release capacity. The drug release behavior of the BPPRH-Cur dressings under different environmental conditions conformed to the logistic and Weibull kinetic models. BPPRH-Cur displayed good antimicrobial activity against common pathogens of wound infections such as E. coli, S. aureus, and P. aeruginosa by destroying the cell membrane and lysing the bacterial cells. This study lays the foundation for the development of new pharmaceutical dressings with positive health, economic and social benefits.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and optimization of acetazolamide nanoparticle-laden contact lens using statistical experimental design for controlled ocular drug delivery. 利用统计实验设计设计和优化含乙酰唑胺纳米颗粒的隐形眼镜，实现眼部药物的可控输送。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-08-19 DOI: 10.1080/09205063.2024.2391233

Disha Chawnani, Ketan Ranch, Chirag Patel, Harshilkumar Jani, Shery Jacob, Moawia M Al-Tabakha, Sai H S Boddu

{"title":"Design and optimization of acetazolamide nanoparticle-laden contact lens using statistical experimental design for controlled ocular drug delivery.","authors":"Disha Chawnani, Ketan Ranch, Chirag Patel, Harshilkumar Jani, Shery Jacob, Moawia M Al-Tabakha, Sai H S Boddu","doi":"10.1080/09205063.2024.2391233","DOIUrl":"https://doi.org/10.1080/09205063.2024.2391233","url":null,"abstract":"This study aims to formulate and evaluate Eudragit nanoparticles-laden hydrogel contact lenses for controlled delivery of acetazolamide (ACZ) using experimental design. Eudragit S-100 was selected for the preparation of nanoparticles. The optimization of Eudragit S100 concentration (X1), polyvinyl alcohol concentration (X2), and the sonication time (X3) was attempted by applying a central composite experimental design. Mean size of nanoparticles (nm), percent in vitro drug release and drug leaching from the ACZ-ENs laden contact lens were considered as dependent variables. Nanoparticles-laden contact lens was prepared through the direct loading method and characterized. Optimum check-point formulation was selected based on validated quadratic polynomial equations developed using response surface methodology. The optimized formulation of ACZ-ENs exhibited spherical shape with a size of 244.3 nm and a zeta potential of -13.2 mV. The entrapment efficiency of nanoparticles was found to be 82.7 ± 1.21%. Transparent contact lenses loaded ACZ-ENs were successfully prepared using the free radical polymerization technique. ACZ-ENs incorporated in contact lens exhibited a swelling of 83.4 ± 0.82% and transmittance of 80.1 ± 1.23%. ACZ-ENs showed a significantly lower burst release of the drug when incorporated in the contact lens and release was sustained over a period of 24 h. The sterilized formulation of ACZ-ENs laden contact lens did not show any sign of toxicity in rabbit eyes. ACZ-ENs incorporated in contact lens could be considered as a potential alternative in glaucoma patients due to their ability to provide sustained drug release and thus enhance patient compliance.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced osteogenesis and antibacterial activity of dual-functional PEEK implants via biomimetic polydopamine modification with chondroitin sulfate and levofloxacin. 通过硫酸软骨素和左氧氟沙星的生物仿生多巴胺修饰增强双功能聚醚醚酮植入物的成骨和抗菌活性。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-08-18 DOI: 10.1080/09205063.2024.2390745

Mengjue Li, Junyan Liu, Yutong Li, Wenyu Chen, Zhou Yang, Yayu Zou, Yi Liu, Yue Lu, Jianfei Cao

{"title":"Enhanced osteogenesis and antibacterial activity of dual-functional PEEK implants via biomimetic polydopamine modification with chondroitin sulfate and levofloxacin.","authors":"Mengjue Li, Junyan Liu, Yutong Li, Wenyu Chen, Zhou Yang, Yayu Zou, Yi Liu, Yue Lu, Jianfei Cao","doi":"10.1080/09205063.2024.2390745","DOIUrl":"https://doi.org/10.1080/09205063.2024.2390745","url":null,"abstract":"Polyetheretherketone (PEEK) implants have emerged as a clinically favored alternative to titanium alloy implants for cranial bone substitutes due to their excellent mechanical properties and biocompatibility. However, the biological inertness of PEEK has hindered its clinical application. To address this issue, we developed a dual-functional surface modification method aimed at enhancing both osteogenesis and antibacterial activity, which was achieved through the sustained release of chondroitin sulfate (CS) and levofloxacin (LVFX) from a biomimetic polydopamine (PDA) coating on the PEEK surface. CS was introduced to promote cell adhesion and osteogenic differentiation. Meanwhile, incorporation of antibiotic LVFX was essential to prevent infections, which are a critical concern in bone defect repairing. To our delight, experiment results demonstrated that the SPKD/CS-LVFX specimen exhibited enhanced hydrophilicity and sustained drug release profiles. Furthermore, in vitro experiments showed that cell growth and adhesion, cell viability, and osteogenic differentiation of mouse calvaria-derived osteoblast precursor (MC3T3-E1) cells were significantly improved on the SPKD/CS-LVFX coating. Antibacterial assays also confirmed that the SPKD/CS-LVFX specimen effectively inhibited the growth of Escherichia coli and Staphylococcus aureus, attributable to the antibiotic LVFX released from the PDA coating. To sum up, this dual-functional PEEK implant showed a promising potential for clinical application in bone defects repairing, providing excellent osteogenic and antibacterial properties through a synergistic approach.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing therapeutic effects alginate microencapsulation of thyme and calendula oils using ionic gelation for controlled drug delivery. 利用离子凝胶技术提高百里香和金盏花油的藻酸盐微胶囊治疗效果，实现可控给药。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-08-18 DOI: 10.1080/09205063.2024.2386220

Cengizhan Çakır, Elif Hatice Gürkan

{"title":"Enhancing therapeutic effects alginate microencapsulation of thyme and calendula oils using ionic gelation for controlled drug delivery.","authors":"Cengizhan Çakır, Elif Hatice Gürkan","doi":"10.1080/09205063.2024.2386220","DOIUrl":"https://doi.org/10.1080/09205063.2024.2386220","url":null,"abstract":"This study focuses on encapsulating and characterizing essential oils such as thyme and calendula oils, which are known for their therapeutic properties but are limited in pharmaceutical formulations due to their low water solubility and instability, with alginate microspheres. Alginate presents an excellent option for microencapsulation due to its biocompatibility and biological degradability. The ionic gelation (IG) technique, based on the ionic binding between alginate and divalent cations, allows the formation of hydrogel materials with high water content, mechanical strength, and biocompatibility. The microspheres were characterized using FT-IR, SEM, and swelling analyses. After determining the encapsulation efficiency and drug loading capacity, the microspheres were subjected to dissolution studies under simulated digestion conditions. It was observed that the swelling percentage of the microspheres in simulated gastric fluid (SGF) ranged from ∼15% to 100%, while in simulated intestinal fluid (SIF) it ranged from ∼150% to 325%. Thyme oil, with low viscosity, exhibited higher encapsulation efficiency than marigold oil. The highest encapsulation efficiency was observed in A-TO-2 microspheres, while the highest drug loading capacity was observed in A-TO-5 microspheres. During the examination of the dissolution profiles of the microspheres, dissolution rates ranging from 10.98% to 23.56% in SGF and from 52.44% to 63.20% in SIF were observed.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication, optimization, and in vitro validation of penicillin-loaded hydrogels for controlled drug delivery. 用于控制药物输送的青霉素负载水凝胶的制造、优化和体外验证。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-08-18 DOI: 10.1080/09205063.2024.2387953

Guiyue Wang, Susu An, Siru Huang, Alamgir, Abdul Wahab, Zahoor Ahmad, Muhammad Suhail, M Zubair Iqbal

{"title":"Fabrication, optimization, and in vitro validation of penicillin-loaded hydrogels for controlled drug delivery.","authors":"Guiyue Wang, Susu An, Siru Huang, Alamgir, Abdul Wahab, Zahoor Ahmad, Muhammad Suhail, M Zubair Iqbal","doi":"10.1080/09205063.2024.2387953","DOIUrl":"https://doi.org/10.1080/09205063.2024.2387953","url":null,"abstract":"Bacterial infections present a major global challenge. Penicillin, a widely used antibiotic known for its effectiveness and safety, is frequently prescribed. However, its short half-life necessitates multiple high-dose daily administrations, leading to severe side-effects. Therefore, this study aims to address these issues by developing hydrogels which control the release of penicillin and alleviate its adverse effects. Various combinations of aspartic acid and acrylamide were crosslinked by N', N'-methylene bisacrylamide through a free radical polymerization process to prepare aspartic acid/acrylamide (Asp/Am) hydrogels. The fabricated hydrogels underwent comprehensive characterization to assess physical properties and thermal stability. The soluble and insoluble fractions and porosity of the synthesized matrix were evaluated by sol-gel and porosity studies. Gel fraction was estimated at 88-96%, whereas sol fraction was found 12-4% and porosity found within the 63-78% range for fabricated hydrogel formulations. Maximum swelling and drug release were seen at pH 7.4, demonstrating a controlled drug release from hydrogel networks. The results showed that swelling, porosity, gel fraction, and drug release increased with higher concentrations of aspartic acid and acrylamide. However, integration of N', N'-methylene bisacrylamide exhibited the opposite effect on swelling and porosity, while increasing gel fraction. All formulations followed the Korsymer-Peppas model of kinetics with 'r' values within the range of 0.9740-0.9980. Furthermore, the cytotoxicity study indicated an effective and safe use of hydrogel because the cell viability was higher than 70%. Therefore, these prepared hydrogels show promise candidates for controlled release of Penicillin and are anticipated to be valuable in clinical applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteoconductive composite membranes produced by rotary jet spinning bioresorbable PLGA for bone regeneration. 通过旋转喷射纺生物可吸收聚乳酸（PLGA）生产用于骨再生的骨传导复合膜。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-08-14 DOI: 10.1080/09205063.2024.2386219

Isabella Caroline Pereira Rodrigues, Karina Danielle Pereira, Augusto Ducati Luchessi, Éder Sócrates Najar Lopes, Laís Pellizzer Gabriel

{"title":"Osteoconductive composite membranes produced by rotary jet spinning bioresorbable PLGA for bone regeneration.","authors":"Isabella Caroline Pereira Rodrigues, Karina Danielle Pereira, Augusto Ducati Luchessi, Éder Sócrates Najar Lopes, Laís Pellizzer Gabriel","doi":"10.1080/09205063.2024.2386219","DOIUrl":"https://doi.org/10.1080/09205063.2024.2386219","url":null,"abstract":"Bone defects and injuries are common, and better solutions are needed for improved regeneration and osseointegration. Bioresorbable membranes hold great potential in bone tissue engineering due to their high surface area and versatility. In this context, polymers such as poly(lactic-co-glycolic acid) (PLGA) can be combined with osteoconductive materials like hydroxyapatite (HA) nanoparticles (NPs) to create membranes with enhanced bioactivity and bone regeneration. Rotary Jet spinning (RJS) is a powerful technique to produce these composite membranes. This study presents an innovative and efficient method to obtain PLGA-HA(NPs) membranes with continuous fibers containing homogeneous HA(NPs) distribution. The membranes demonstrated stable thermal degradation, allowing HA(NPs) quantification. In addition, the PLGA-HA(NPs) presented osteoconductivity, were not cytotoxic, and had high cell adhesion when cultured with pre-osteoblastic cells. These findings demonstrate the potential of RJS to produce PLGA-HA(NPs) membranes for easy and effective application in bone regeneration.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oil/water (O/W) nanoemulsions developed from essential oil extracted from wildly growing Calotropis gigantea (Linn.) Aiton F.: synthesis, characterization, stability and evaluation of anti-cancerous, anti-oxidant, anti-inflammatory and anti-diabetic activities. 从野外生长的菖蒲（Calotropis gigantea (Linn.) Aiton F.）中提取的精油开发的油/水（O/W）纳米乳剂：合成、表征、稳定性以及抗癌、抗氧化、抗炎和抗糖尿病活性评估。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-08-13 DOI: 10.1080/09205063.2024.2384801

Arun Dev Sharma, Ravindresh Chhabra, Jyoti Rani, Amrita Chauhan, Inderjeet Kaur, Gaurika Kapoor

{"title":"Oil/water (O/W) nanoemulsions developed from essential oil extracted from wildly growing Calotropis gigantea (Linn.) Aiton F.: synthesis, characterization, stability and evaluation of anti-cancerous, anti-oxidant, anti-inflammatory and anti-diabetic activities.","authors":"Arun Dev Sharma, Ravindresh Chhabra, Jyoti Rani, Amrita Chauhan, Inderjeet Kaur, Gaurika Kapoor","doi":"10.1080/09205063.2024.2384801","DOIUrl":"https://doi.org/10.1080/09205063.2024.2384801","url":null,"abstract":"Calotropis gigantea essential oil is utilized in outmoded medicine, therapeutics, and the cosmetic industries. However, the extreme volatility, oxidation susceptibility, and instability of this oil restricts its application. Thus, encapsulation is a more effective method of shielding this oil from unfavorable circumstances. The creation of oil/water (O/W) nanoemulsions based on Calotropis gigantea essential oil (CEO), known as CNE (Calotropis gigantea essential oil nanoemulsions), and an assessment of its biological potential were the goals of this work. UV, fluorescence, and FT-IR methods were used for physiological characterization. Biological activities, including anti-inflammatory, anti-diabetic, and anti-cancer effects. Studies on the pharmacokinetics of CNE were conducted. CNEs encapsulation efficiency was found to be 92%. The CNE nanoemulsions had a spherical shape with polydispersity index of 0.531, size of 200 nm, and a zeta potential of -35.9 mV. Even after being stored at various temperatures for 50 days, CNE nanoemulsions remained stable. Numerous tests were used to determine the antioxidant capacity of CNE, and the following IC50 values (µl/mL) were found: iron chelating assay: 18, hydroxyl radical scavenging: 37, and nitric oxide radical scavenging activity: 58. The percentage of HeLa cells that remained viable after being treated with CNE was 41% at a higher dose of 1 µl. CNE inhibited α-amylase in a dose-dependent manner, with 72% inhibition at its higher dose of 250 µL. Research on the kinetics of drugs showed that nanoemulsions showed Higuchi pattern. This research showed potential use of Calotropis gigantea oil-based nanoemulsions in the food, cosmetic, and pharmaceutical industries.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Composite hydrogels fabricated from CMC-PVA-GG incorporated with ZiF-8 for wound healing applications. 将 CMC-PVA-GG 与 ZiF-8 结合制成复合水凝胶，用于伤口愈合。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2024-08-07 DOI: 10.1080/09205063.2024.2386224

Tooba Yasin, Muhammad Azhar Aslam, Haamid Jamil, Abdalla Abdal-Hay, Hassan Fouad, Humaira Masood Siddiqi, Muhammad Umar Aslam Khan

{"title":"Composite hydrogels fabricated from CMC-PVA-GG incorporated with ZiF-8 for wound healing applications.","authors":"Tooba Yasin, Muhammad Azhar Aslam, Haamid Jamil, Abdalla Abdal-Hay, Hassan Fouad, Humaira Masood Siddiqi, Muhammad Umar Aslam Khan","doi":"10.1080/09205063.2024.2386224","DOIUrl":"https://doi.org/10.1080/09205063.2024.2386224","url":null,"abstract":"The skin is at risk for injury to external factors since it serves as the body's first line of defense against the external environment. Hydrogels have drawn much interest due to their intrinsic extracellular matrix (ECM) properties and their biomimetic, structural, and durable mechanical characteristics. Hydrogels have enormous potential use in skin wound healing due to their ability to deliver bioactive substances easily. In this study, composite hydrogels were developed by blending guar gum (GG), polyvinyl alcohol (PVA), and carboxymethyl cellulose (CMC) with crosslinker TEOS for skin wound treatment. The structural, surface morphology, surface roughness, and stability features of the composite hydrogels were characterized by several techniques, such as FTIR, SEM-EDX, AFM, and DSC. The increasing ZiF-8 causes more surface roughness, with decreased swelling in different media (Aqueous > PBS > NaCl). The increasing ZiF-8 amount causes less hydrophilic behavior and biodegradation with increasing gel fraction. The cytocompatibility of Zinc imidazolate framework-8 (ZiF-8) based composites was evaluated against fibroblast cell lines by cell viability, proliferation, and cell morphology. The increasing ZiF-8 caused more cell viability and proliferation with proper cell morphology. Hence, the results show that synthesized composite hydrogels may be a potential candidate for numerous wound repair applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0