Journal of Biomaterials Science, Polymer Edition最新文献_第5页

PPDO-induced tunable degradation and HA-enhanced osteogenesis in PLCL scaffolds for bone regeneration. ppdo诱导的可调节降解和ha增强PLCL支架骨再生的成骨作用。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-16 DOI: 10.1080/09205063.2025.2519868

Jianfei Cao, Chao Peng, Yan Lei, Haoming Wu, Shaojuan Xu, Qiyu Liu, Yi Liu, Mengjue Li, Yue Lu

{"title":"PPDO-induced tunable degradation and HA-enhanced osteogenesis in PLCL scaffolds for bone regeneration.","authors":"Jianfei Cao, Chao Peng, Yan Lei, Haoming Wu, Shaojuan Xu, Qiyu Liu, Yi Liu, Mengjue Li, Yue Lu","doi":"10.1080/09205063.2025.2519868","DOIUrl":"https://doi.org/10.1080/09205063.2025.2519868","url":null,"abstract":"Poly(lacticacid-ε-caprolactone) (PLCL) scaffolds face significant challenges in bone regeneration due to excessively slow degradation kinetics and inherent hydrophobicity. To overcome these limitations, we developed a novel ternary 3D-printed scaffold composed of PLCL, poly(p-dioxanone) (PPDO), and hydroxyapatite (HA) via fused deposition modeling (FDM) for the first time. The incorporation of PPDO would accelerate and enable tunable degradation of PLCL to match the bone healing timeline, while HA was aimed to enhance osteoinductivity and regulated the pH level to reduce adverse immune reactions of the acidic degradation products. The results demonstrated that degradation rate of the scaffolds was found to be modulated by PPDO and HA effectively. Moreover, the 3D printing extrusion enabled the porous scaffolds with customizability, diverse shapes, adjustable porosity and uniform pore sizes. In addition, proliferation and adhesion of bone marrow mesenchymal stem cells (BMSCs) as well as the expression of various osteogenic genes (ALP, Col-Ι, OCN, BMP-2, OPN) were also upregulated on the PLCL/PPDO/HA scaffolds. Therefore, these low-cost 3D-printed scaffolds may serve as an optimal bone graft for applications in bone tissue engineering.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-17"},"PeriodicalIF":3.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gelatin modified nonisocyanate polyurethane/siloxane functionalized with quaternary ammonium groups as antibacterial wound dressing membrane. 明胶改性季铵基非异氰酸酯聚氨酯/硅氧烷抗菌创面敷料膜。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-16 DOI: 10.1080/09205063.2025.2518305

Parsa Mousavi, Hamid Yeganeh, Ismail Omrani, Masoud Babaahmadi

{"title":"Gelatin modified nonisocyanate polyurethane/siloxane functionalized with quaternary ammonium groups as antibacterial wound dressing membrane.","authors":"Parsa Mousavi, Hamid Yeganeh, Ismail Omrani, Masoud Babaahmadi","doi":"10.1080/09205063.2025.2518305","DOIUrl":"https://doi.org/10.1080/09205063.2025.2518305","url":null,"abstract":"This work presents antibacterial wound dressing membranes based on a nonisocyanate polyurethane-siloxane framework. These membranes protect wounded skin by providing mechanical strength, maintaining a moist environment, and ensuring hygiene through chemically anchored antibacterial moieties. Methoxysilane-functionalized soybean oil-based polyhydroxyurethane with quaternary ammonium groups was synthesized and combined with GPTMS and TEOS. Hydrolysis-condensation reactions formed membranes with siloxane domains and pendant epoxy groups. Gelatin was incorporated to enhance biocompatibility and mechanical strength. The resulting films demonstrated tensile strengths of 7.9 MPa (dry) and 0.61 MPa (swelled). Fluid handling capacities were 2.66-2.81 g/10 cm2/day (serum) and 0.79-1.10 g/10 cm2/day (serum vapor), making them suitable for light to moderately exuding wounds. Cytocompatibility was confirmed by MTT assays, showing over 80% fibroblast viability on dressings and over 90% viability in leachate-containing media. The blood compatibility of the dressing was confirmed by standard methods. The dressings also exhibited strong antibacterial activity, with 82% killing of Staphylococcus aureus and 52% killing of Escherichia coli. These results highlight the potential of these membranes for advanced wound care applications.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An in vitro study to assess halide-containing glass-coated surgical suture for bone regeneration in implant surgery. 评估含卤化物玻璃涂层外科缝合线用于种植体手术骨再生的体外研究。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-16 DOI: 10.1080/09205063.2025.2504022

Ahmed Al-Noaman, Simon Rawlinson

{"title":"An in vitro study to assess halide-containing glass-coated surgical suture for bone regeneration in implant surgery.","authors":"Ahmed Al-Noaman, Simon Rawlinson","doi":"10.1080/09205063.2025.2504022","DOIUrl":"10.1080/09205063.2025.2504022","url":null,"abstract":"Polyglycolic acid (PGA) suture is a synthetic, absorbable, and biocompatible material. However, it lacks bioactivity and cannot bond with osseous tissue. Bioactive glasses have the ability to form surface apatite and bond with bone, but they are brittle and therefore difficult to shape in the operating room. PGA sutures were coated with chloride-silicate glass (CSG) using the slurry dipping technique. The CSG-coated sutures were characterized before and after immersion in simulated body fluid (SBF) by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS). The adhesion of the glass coating to the PGA suture was assessed by the knot performance test. The bioactivity of the coated sutures was investigated in SBF) after 7, 14, 21, and 28 days of immersion. The pH variation of the SBF was measured using a pH meter. Tensile strength of the bare and coated sutures was quantified using a universal testing machine before and after immersion in SBF, and the cytotoxicity was assessed using osteoblast-like cells after 24, 48, 72, and 168h. The results revealed that the coating covered and adhered to the surgical suture. The coated suture had the ability to form a small size or low amount of apatite after 7 days of immersion. The CSG coating exhibited a tendency to increase the tensile strength of the suture, but this increase was not statistically significant. The glass coating was not cytotoxic to osteoblast-like cells. It is suggested that PGA sutures coated with CSG could be used as a potential material to promote bone regeneration.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-18"},"PeriodicalIF":3.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review of dental bone regeneration. 牙骨再生研究综述。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-16 DOI: 10.1080/09205063.2025.2515953

Megha Satpathy

{"title":"A comprehensive review of dental bone regeneration.","authors":"Megha Satpathy","doi":"10.1080/09205063.2025.2515953","DOIUrl":"https://doi.org/10.1080/09205063.2025.2515953","url":null,"abstract":"This review provides an in-depth analysis of dental bone regeneration, tracing its evolution and applications. Recent advancements in dental bone regeneration have allowed the utilization of barrier membranes to direct the regeneration process, excluding undesired cell types and fostering the growth of beneficial tissues, particularly in treating periodontal and bone defects. Over the past forty years, bone regeneration has advanced significantly, effectively enhancing periodontal ligament restoration while preventing unwanted soft-tissue growth. It is widely applied in periodontal, oral, implant, and jawbone surgeries, offering benefits such as restoring functionality and aesthetics of damaged tissues. The review also explores the structure of bone, emphasizing its biphasic nature with collagen and hydroxyapatite, which are crucial for maintaining bone strength and mechanical properties. As dental diseases like periodontitis and trauma become more prevalent, bone regeneration has gained prominence. Various graft materials, synthetic biomaterials, and techniques for creating scaffold designs have been explored. Understanding these regeneration mechanisms is key to improving dental treatments, and patient outcomes, and addressing challenges in oral health care.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-40"},"PeriodicalIF":3.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances, mechanisms, and applications of natural medicines incorporated hydrogel-based drug delivery systems for enhancing wound-healing efficacy. 天然药物的最新进展、机制和应用包括水凝胶为基础的给药系统，以提高伤口愈合的疗效。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-11 DOI: 10.1080/09205063.2025.2511992

Awn Abbas, Muhammad Asim Raza, Xiaoyang Ai, Sadia, Hua Liao, Nanxin Li, Sameera Naseer, Dongbo Li, Yifan Zhang, Lian Chen, Wei Zhang, Gang Shu, Hualin Fu

{"title":"Recent advances, mechanisms, and applications of natural medicines incorporated hydrogel-based drug delivery systems for enhancing wound-healing efficacy.","authors":"Awn Abbas, Muhammad Asim Raza, Xiaoyang Ai, Sadia, Hua Liao, Nanxin Li, Sameera Naseer, Dongbo Li, Yifan Zhang, Lian Chen, Wei Zhang, Gang Shu, Hualin Fu","doi":"10.1080/09205063.2025.2511992","DOIUrl":"https://doi.org/10.1080/09205063.2025.2511992","url":null,"abstract":"Trauma results in wounds and triggers a response from the immune system to repair the damage, and can lead to severe physical complications if it is left untreated. Various drugs are applied through different drug delivery systems, e.g. hydrogels, hydrocolloids, scaffolds, nano-composite membranes, and nanofibers, etc. to cure the wound. Despite advancements in trauma care and management, infection remains a substantial cause of loss for millions of individuals with wounds globally. Natural medicine (NMs) remedies derived from plant sources are used in ailments due to their therapeutic properties and holistic healing effects. Due to the high risk of antibiotic resistance, NMs have been widely used in reversing bacterial resistance and wound healing. NMs have been reported for healing effects, however, the lack of an appropriate drug delivery system is posing difficulty in achieving their maximum potential applications. In this regard, hydrogel-based systems are ideal among all drug delivery systems due to their controlled release properties and biocompatibility. This review focuses on mechanisms of trauma repair, highlights the advantages and applications of selected NMs, and provides insights into the study gaps and prospects.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-23"},"PeriodicalIF":3.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Two new Cu(II)-based coordination polymers: inhibitory activity on prostate cancer by reducing EGF-R expression and HIPPO signaling pathway activation. 撤回声明：两种新的Cu（II）基配位聚合物：通过降低EGF-R表达和HIPPO信号通路激活对前列腺癌的抑制活性。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-10 DOI: 10.1080/09205063.2025.2513787

引用次数: 0

Hyaluronic acid-functionalized Axitinib nanomicelles for targeted drug delivery in breast cancer therapy. 透明质酸功能化的阿西替尼纳米胶束在乳腺癌治疗中的靶向药物递送。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-10 DOI: 10.1080/09205063.2025.2515944

Sruthi Laakshmi Mugundhan, Mothilal Mohan

{"title":"Hyaluronic acid-functionalized Axitinib nanomicelles for targeted drug delivery in breast cancer therapy.","authors":"Sruthi Laakshmi Mugundhan, Mothilal Mohan","doi":"10.1080/09205063.2025.2515944","DOIUrl":"https://doi.org/10.1080/09205063.2025.2515944","url":null,"abstract":"Breast cancer therapy with Axitinib (AXT), a potent tyrosine kinase inhibitor, is limited by poor aqueous solubility, rapid clearance, and off-target toxicity. To address these challenges, we developed AXT-loaded nanomicelles (AXT-M) composed of Triton X-100, Brij-35, and Vitamin-E TPGS, with surface functionalization using hyaluronic acid (HA) for CD44 receptor-mediated targeting (HA-AXT-M). This formulation aims to enhance solubility, improve tumour specificity, and reduce systemic toxicity. The formulation was characterized for particle size, zeta potential, and encapsulation efficiency. Additionally, in vitro drug release, cytotoxicity using the MTT assay in MCF-7 cells, and stability studies under various storage and dilution conditions were performed. The optimized HA-AXT-M showed a particle size of 244.27 ± 1.04 nm, zeta potential of -27.3 mV, and encapsulation efficiency of 87.92%. Drug release studies demonstrated a biphasic release pattern with sustained release over 24 h. Cytotoxicity assays revealed enhanced anticancer activity of HA-AXT-M compared to uncoated micelles and free Axitinib. Stability studies confirmed the physical and chemical stability of the formulation. Moreover, HA functionalization substantially improved cellular uptake and selective targeting of CD44-overexpressing breast cancer cells, minimizing off-target effects. These findings highlight the promise of HA-AXT-M as a targeted nanocarrier platform that enhances the therapeutic potential of Axitinib. This novel delivery system offers improved efficacy, tumour selectivity, and translational relevance for breast cancer therapy.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-29"},"PeriodicalIF":3.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and fabrication of polymer-coated vincristine-loaded core - shell iron nanoparticle system with mitochondrial-targeted ultrasound improved colorectal cancer therapy. 基于线粒体靶向超声的聚合物包被长春新碱负载核壳铁纳米粒子系统的设计与制备改善了结直肠癌的治疗。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-09 DOI: 10.1080/09205063.2025.2501095

Yanbin Chen, Xiaodong Xu, Xinye Hu

引用次数: 0

Fabrication of novel biomimetic nano-hydroxyapatite/chitosan injectable hydrogel with chikusetusaponin IVa on chondral injury in osteoarthritis. 新型仿生纳米羟基磷灰石/壳聚糖注射水凝胶的制备及其对骨关节炎软骨损伤的影响。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-07 DOI: 10.1080/09205063.2025.2501101

Jiang-Li Zhang, Jin-Hui Liu, Xi-Qing Pan, Guang-Yuan Liu, Meng-Hui Wu, Xiao Fan

{"title":"Fabrication of novel biomimetic nano-hydroxyapatite/chitosan injectable hydrogel with chikusetusaponin IVa on chondral injury in osteoarthritis.","authors":"Jiang-Li Zhang, Jin-Hui Liu, Xi-Qing Pan, Guang-Yuan Liu, Meng-Hui Wu, Xiao Fan","doi":"10.1080/09205063.2025.2501101","DOIUrl":"https://doi.org/10.1080/09205063.2025.2501101","url":null,"abstract":"The management of pain and the chondral injury resulting from osteoarthritis (OA) present serious challenges in clinical treatment. The conventional method of injecting hyaluronic acid (HA) directly into the joint can alleviate the condition, but it is constrained by the challenge of preserving its effectiveness over an extended time. Recent studies indicate that the total Chikusetusaponin IVa (ChS IVa) found in the Panax japonicas have the ability to reduce oxidative stress and inflammation. This study involved the development of a new hydrogel formulation by combining nano-hydroxyapatite-modified chitosan hydrogel with encapsulated Chikusetusaponin IVa (ChS IVa-nHA/CS) to treat osteoarthritis (OA). The supramolecular ChS IVa-nHA/CS hydrogel exhibited favorable biocompatibility to chondrocytes and demonstrated potent antioxidant activity in vitro. During the 24-hour degradation studies, it was observed that the sample exhibited greater resistance to chemical degradation compared to the HA samples. An in vitro study demonstrated that the administration of this novel hydrogel through intra-articular injection can effectively reduce the local inflammation in knee joints. This results in suppressing the production of inflammatory cytokines (COX-2, iNOS, TNF-α, IL-1β, IL-6, IL-17) in the chondrocytes (cartilage cells) at 12 weeks after the injection. Histological and behavioral evaluations proved that the administration of hydrogel injection provided protection against cartilage degradation and alleviated pain in rats with osteoarthritis, as compared to the treatment of HA injection. This novel hydrogel, overcoming the traditional HA injection, indicates significant potential for treating OA.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-31"},"PeriodicalIF":3.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering anti-contractile 3D cellular assemblies using micronozzle-generated fragmented collagen microfibers. 工程抗收缩的3D细胞组件使用微喷嘴产生的碎片胶原微纤维。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-06-06 DOI: 10.1080/09205063.2025.2512894

Keigo Yamanaka, Yuri Shimoda, Rina Nonogaki, Rie Utoh, Masumi Yamada

{"title":"Engineering anti-contractile 3D cellular assemblies using micronozzle-generated fragmented collagen microfibers.","authors":"Keigo Yamanaka, Yuri Shimoda, Rina Nonogaki, Rie Utoh, Masumi Yamada","doi":"10.1080/09205063.2025.2512894","DOIUrl":"https://doi.org/10.1080/09205063.2025.2512894","url":null,"abstract":"The organization of mammalian cells into three-dimensional (3D) architectures has diverse applications in tissue engineering, regenerative medicine, and in vitro drug screening and evaluation. Incorporation of bioactive polymer-based substrates, engineered into cell-sized materials holds significant promise in modulating the shortage of oxygen and nutrients supply, but conventional techniques face limitations in producing such small materials at high throughput. In this study, we present a facile and versatile strategy for the high-throughput production of fragmented collagen microfibers (F-CMFs) using micronozzle-assisted extrusion and stirring-induced shear forces. By carefully controlling the composition of the gelation agent solution for type-I collagen, particularly the concentrations of a polyanion and a thickener, we were able to precisely design the morphology of F-CMFs. As a practical application, we fabricated dermal tissue models using F-CMFs of varying lengths, in which F-CMFs effectively suppressed cell-driven tissue contraction. Furthermore, we demonstrated the formation of multilayered human skin tissue models comprising dermal and epidermal layers in microchannel-integrated chambers. The proposed approach offers a novel modality for creating diverse tissue models that can precisely control tissue shape and potentially enhance cellular functions through cell-matrix interactions.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-17"},"PeriodicalIF":3.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0