Journal of Biomaterials Science, Polymer Edition最新文献_第6页

Combination therapy of fingolimod-GelMA hydrogel loaded with neural stem cells and electrical stimulation promotes recovery of spinal cord injury. 负载神经干细胞的fingolimod-GelMA水凝胶与电刺激联合治疗可促进脊髓损伤的恢复。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-05 DOI: 10.1080/09205063.2025.2541973

Yongkang Dong, Zheng Wang, Yang Qu, Weijian Kong, Changjun Zheng

{"title":"Combination therapy of fingolimod-GelMA hydrogel loaded with neural stem cells and electrical stimulation promotes recovery of spinal cord injury.","authors":"Yongkang Dong, Zheng Wang, Yang Qu, Weijian Kong, Changjun Zheng","doi":"10.1080/09205063.2025.2541973","DOIUrl":"https://doi.org/10.1080/09205063.2025.2541973","url":null,"abstract":"Spinal cord injury (SCI) is one of the most devastating diseases worldwide, and its recovery is hindered by damage and loss of nerve endings leading to loss of neurons and formation of glial scars. In this study, an injectable GelMA hydrogel incorporating neural stem cells (NSCs) and fingolimod (FTY720), combined with electrical stimulation (ES), was developed to enhance neural regeneration and suppress glial scar formation in a rat SCI model of complete spinal cord transection. The combined therapy of ES and injectable hydrogel incorporated with FTY720 improved both proliferation and neuronal differentiation and inhibited astrocytic differentiation of NSCs in vitro. When applied to a complete transected SCI rat model, the combined therapy significantly enhanced neuronal regeneration and reduced glial scar formation in the lesioned area, thus resulting in better motor function recovery. Taken together, this research demonstrated a promising FTY720 enhanced GelMA hydrogel loaded with NSCs for exogenous NSCs delivery and provided a novel strategy for combination therapy of SCI.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-22"},"PeriodicalIF":3.6,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prilocaine-loaded silicone dressing with dual-functionality: integrated pain management and wound protection for burn care. 具有双重功能的含有丙胺卡因的硅胶敷料：烧伤护理的综合疼痛管理和伤口保护。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-05 DOI: 10.1080/09205063.2025.2522751

Yanshu Lu, Yi Peng, Jia Cheng, Zhaochen Hu, Fengbo Yang, Xiaoli Jia, Chunjing Yu, Ling Diao, Guozhong Lyu

{"title":"Prilocaine-loaded silicone dressing with dual-functionality: integrated pain management and wound protection for burn care.","authors":"Yanshu Lu, Yi Peng, Jia Cheng, Zhaochen Hu, Fengbo Yang, Xiaoli Jia, Chunjing Yu, Ling Diao, Guozhong Lyu","doi":"10.1080/09205063.2025.2522751","DOIUrl":"https://doi.org/10.1080/09205063.2025.2522751","url":null,"abstract":"Burn wounds encompass skin injuries resulting from exposure to thermal, cryogenic, electrical, chemical, radioactive, and frictional agents. Disruption of the skin barrier and an exaggerated inflammatory response contribute to the impaired healing of these wounds. With the development of burn wound treatment technology, the importance of comfortable treatment for burn wound is becoming increasingly prominent. In this paper, we designed a multifunctional wound dressing based on silicone gel. This dressing incorporated the analgesic drug prilocaine into the polyvinyl alcohol (PVA) coating to provide pain relief. This ensures prolonged and controlled drug release, achieving effective analgesia and wound protection. We used positron emission tomography/computed tomography (PET/CT) scanning to compare pain levels in rats, and favorable results were obtained in animal experiments. The PET/CT results showed a significant decrease in pain indicators in the experimental group compared to the control group, confirming that the analgesic function of the dressing designed in this study is effective. In conclusion, our study provides a new perspective on burn wound dressings and offers a potential new approach to alleviating severe pain associated with burn wounds.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-26"},"PeriodicalIF":3.6,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mimicking techniques in small diameter vascular grafts: enhancing design through multi-layered electrospinning techniques. 小直径血管移植物的模拟技术：通过多层静电纺丝技术增强设计。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-04 DOI: 10.1080/09205063.2025.2537734

Degu Melaku Kumelachew

{"title":"Mimicking techniques in small diameter vascular grafts: enhancing design through multi-layered electrospinning techniques.","authors":"Degu Melaku Kumelachew","doi":"10.1080/09205063.2025.2537734","DOIUrl":"https://doi.org/10.1080/09205063.2025.2537734","url":null,"abstract":"The increasing prevalence of occlusive arterial diseases, such as peripheral arterial disease and coronary heart disease, underscores the critical need for effective vascular interventions. Traditional methods, including autologous vessel grafting, often fall short in the case of small-diameter vascular grafts (SDVGs), which present challenges such as thrombosis and limited long-term patency. This study reviews recent advancements in electrospinning techniques aimed at generating biomimetic SDVGs that closely replicate the structure and mechanical properties of natural blood vessels. By employing multi-layered electrospinning approaches, the review investigates strategies to enhance scaffold design, improve biocompatibility, and integrate bioactive components. The potential of novel drug delivery systems and advanced porogenic technologies is also explored, revealing a pathway to create next-generation electrospun vascular grafts that promise improved integration with host tissues and a substantial impact on cardiovascular therapies. This review highlights the ongoing efforts within the field of tissue engineering to address the pressing challenges associated with small-diameter vascular grafts, facilitating better patient outcomes, and expanding therapeutic options.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-27"},"PeriodicalIF":3.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyaluronic acid-coated cubosomal in situ gel for Brimonidine Tartrate: a sustained delivery system with enhanced ocular bioavailability and intraocular pressure reduction. 透明质酸包被的酒石酸溴莫尼定原位凝胶：一种增强眼部生物利用度和降低眼压的持续给药系统。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-04 DOI: 10.1080/09205063.2025.2543071

Harsh P Nijhawan, Janhvi Vyas, Piyush Verma, Khushwant S Yadav

{"title":"Hyaluronic acid-coated cubosomal in situ gel for Brimonidine Tartrate: a sustained delivery system with enhanced ocular bioavailability and intraocular pressure reduction.","authors":"Harsh P Nijhawan, Janhvi Vyas, Piyush Verma, Khushwant S Yadav","doi":"10.1080/09205063.2025.2543071","DOIUrl":"https://doi.org/10.1080/09205063.2025.2543071","url":null,"abstract":"Glaucoma causes irreversible blindness, with poor adherence driven by frequent dosing and low eye drop bioavailability. Brimonidine tartrate (BRT) requires multiple daily doses due to rapid elimination and limited corneal permeability. To address these limitations, this study aimed to develop a long-acting, mucoadhesive ocular delivery system using hyaluronic acid-coated cubosomes (HA-BRT-CUB), further incorporated into a thermoresponsive in situ gel (HA-BRT-CUB-ISG). The HA-BRT-CUB formulation was optimized using a Design of Experiments (DoE) approach, resulting in a particle size of 189.24 ± 2.05 nm, zeta potential of -25.45 ± 0.88 mV, and entrapment efficiency of 78.86 ± 2.42%. Incorporation into a poloxamer-based ISG system enhanced precorneal retention and sustained delivery. In vitro release from HA-BRT-CUB-ISG was extended over 24 h (h), best fitting the Korsmeyer-Peppas model (R2 = 0.981). Ex vivo permeation studies revealed a flux (J) of 2.89 µg/cm2/h and a 3.92-fold enhancement ratio (ER) compared to the BRT solution. In normotensive New Zealand rabbits, HA-BRT-CUB-ISG achieved a 30.31% IOP reduction at 24 h (17.05 ± 0.35 mmHg), compared to 29.91% with HA-BRT-CUB and only 20.75% with Alphagan®. Pharmacokinetic analysis revealed that HA-BRT-CUB-ISG attained a Cmax of 7.35 ± 0.82 μg/mL and an AUC0-∞ of 70.22 ± 3.56 µg/mL* h, representing a 4.5- and 12-fold improvement, respectively, over Alphagan®. The half-life extended to 8.75 ± 1.34 h with minimal clearance (Cl/F = 1.42 ± 0.59). Stability studies confirmed HA-BRT-CUB formulation integrity under refrigerated conditions over 90 days. Overall, HA-BRT-CUB-ISG presents a promising once-daily nanocarrier system for sustained glaucoma management.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-34"},"PeriodicalIF":3.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hierarchically functionalized PCL/CS with synergistic PDA-mediated antioxidant therapy and NGF-activated neurogenesis for spinal cord injury regeneration. 分层功能化PCL/CS协同pda介导的抗氧化治疗和ngf激活的神经发生用于脊髓损伤再生。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-03 DOI: 10.1080/09205063.2025.2542479

Ling Peng, Yusong Pan, Qianqian Liu, Cuilian Wei, Run Huang, Wenjie Luo, Xiuling Lin, Jun Tao, Yinghai Xie

{"title":"Hierarchically functionalized PCL/CS with synergistic PDA-mediated antioxidant therapy and NGF-activated neurogenesis for spinal cord injury regeneration.","authors":"Ling Peng, Yusong Pan, Qianqian Liu, Cuilian Wei, Run Huang, Wenjie Luo, Xiuling Lin, Jun Tao, Yinghai Xie","doi":"10.1080/09205063.2025.2542479","DOIUrl":"https://doi.org/10.1080/09205063.2025.2542479","url":null,"abstract":"Spinal cord injury (SCI) is a common disease worldwide. Tissue engineering scaffolds are considered a promising strategy for SCI treatment, but their efficacy is significantly limited by the local abundance of MSC (mesenchymal stem cell) and a highly inflammatory microenvironment. In this study, a multifunctional composite scaffold of polycaprolactone/chitosan (PCL/CS) loading polydopamine (PDA)-coated nerve growth factor (NGF) loaded onto was prepared using a freeze-drying method. The PCL/CS composite scaffold exhibited tunable degradation properties and excellent biocompatibility. The PDA coating demonstrated potent free radical scavenging capabilities, achieving clearance rate of 90.65%, 77.53%, and 60.77% for DPPH, H2O2, and ·OH radicals, respectively. Remarkably, the scaffold effectively reduced intracellular ROS levels within 24 h under oxidative stress conditions. Flow cytometry revealed rapid cellular internalization, with the FITC-labeled PC-5-PDA group exhibiting a 99.87% FITC+ rate within 12 h. NGF release from the scaffold induced robust neuronal differentiation of PC-12 cells, as evidenced by a 58.1% increase in neurite length (from 104.77 μm at day 3 to 165.66 μm at day 4) and upregulated expression of microtubule-associated protein 2 (MAP2). These findings demonstrate the dual functionality of the scaffold, which is effectively modulating the post-SCI inflammatory microenvironment while promoting neural regeneration.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-24"},"PeriodicalIF":3.6,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrative computational and experimental study of propolis, polyvinyl alcohol, and alhagi maurorum complex as anticancer and antibacterial agents. 蜂胶、聚乙烯醇、毛藻配合物抗癌抗菌的综合计算与实验研究。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-02-24 DOI: 10.1080/09205063.2025.2464448

Asra Ali Hussein, Nisreen Kaddim Radi, Nebras Mohammed Sahi

{"title":"Integrative computational and experimental study of propolis, polyvinyl alcohol, and alhagi maurorum complex as anticancer and antibacterial agents.","authors":"Asra Ali Hussein, Nisreen Kaddim Radi, Nebras Mohammed Sahi","doi":"10.1080/09205063.2025.2464448","DOIUrl":"10.1080/09205063.2025.2464448","url":null,"abstract":"The study examined the potential applications of propolis, polyvinyl alcohol (PVA), and Alhagi maurorum extracts in drug delivery systems, utilizing both computer and lab methods. The study uses molecular docking probes along with DFT (density functional theory) to investigate molecular interactions and examine the binding of drugs to carrier materials. The HOMO (Highest Occupied Molecular Orbital)-LUMO (Lowest Occupied Molecular Orbital) gap for the mix of PVA, galangin, and triterpene glycoside is -0.07621 eV, which matches the experiment results. This small gap enhances responsiveness in drug delivery applications, which is crucial for successful interactions with biological targets. It's possible that a delivery system that combines galangin and triterpene glycosides would work better and be more compatible with living things.The experimental results of the Methyl Thiazole Tetrazolium (MTT) show consistent findings: The viability of MCF7, a human breast cancer cell line, significantly decreased at all concentrations of propolis and polyvinyl alcohol compared to WRL68, a fetal liver cell line. Within-group comparisons showed less viability in both groups at 400 µg/ml. Mean ± SD: 42.05267 ± 1.951655; 67.12533 ± 7.401263.In the positive control group, the average number of malignant cells was 47.06, but the average number of cells in the fourth treatment (Propolis + PVA) and the third combination (Propolis + Alhagi maurorum + PVA) were 42.05267 and 42.97800, respectively. The Sustainable Development Goals in Industry and Innovation are focusing on developing a new combination of alhagi and propolis using PVA as a polymer carrier.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1718-1748"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amphoteric ionic hydrogels containing graphene oxide and bioactive glass loaded with BMP-2 significantly promoted the proliferation and osteogenic differentiation of BMSCs. 含有氧化石墨烯和生物活性玻璃的两性离子水凝胶可显著促进骨髓间充质干细胞的增殖和成骨分化。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-03-26 DOI: 10.1080/09205063.2025.2480881

Yaru Zhu, Ruiming Yan, Tao Wang, Qidong Wang

引用次数: 0

Effects of poly(acrylic acid)'s crosslinker content on pulmonary toxicity in rats. 聚丙烯酸交联剂含量对大鼠肺毒性的影响。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-03-02 DOI: 10.1080/09205063.2025.2463268

Masayuki Yokoyama, Takamasa Kido, Koichi Shiraishi, Machi Suka, Hiroyuki Yanagisawa

引用次数: 0

Enhancing Bone Grafts: Unveiling the Degradation Behaviour of Poly (lactic‑co‑glycolic acid) ‑ Calcium Composites for Advanced Bone Repair. 增强骨移植物：揭示用于高级骨修复的聚乳酸- co -乙醇酸-钙复合材料的降解行为。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-02-07 DOI: 10.1080/09205063.2025.2460370

Norshazliza Ab Ghani, Sathiya Maran, Mohammed Rafiq Abdul Kadir, Shanmathy Somasundaram, Hanumantha Rao Balaji Raghavendran, Tunku Kamarul Zaman

{"title":"Enhancing Bone Grafts: Unveiling the Degradation Behaviour of Poly (lactic‑co‑glycolic acid) ‑ Calcium Composites for Advanced Bone Repair.","authors":"Norshazliza Ab Ghani, Sathiya Maran, Mohammed Rafiq Abdul Kadir, Shanmathy Somasundaram, Hanumantha Rao Balaji Raghavendran, Tunku Kamarul Zaman","doi":"10.1080/09205063.2025.2460370","DOIUrl":"10.1080/09205063.2025.2460370","url":null,"abstract":"In orthopaedic clinical applications, creating biocomposite bone substitutes to take the place of autologous bone transplants is still difficult. Studies have demonstrated for decades that poly (lactic-co-glycolic acid) [PLGA], a common polymer, has many benefits that make it a strong contender for bone replacement. These include biodegradability, good mechanical qualities, and the ability to induce new bone production. Although calcium-based materials are frequently used as bone fillers in bone implantation, the efficiency of ceramic materials containing calcium may be hampered by a number of issues, including low microporosity and quick rates of degradation. In order to overcome these obstacles, scientists are investigating ways to improve implant performance by combining PLGA with other materials, especially in terms of encouraging improved connections with nearby bone cells. An overview of the chemical properties of different PLGA-based scaffold composites, as well as the benefits and drawbacks of PLGA-Calcium implants in tissue engineering applications, are the goals of this review. It also highlights the possible advantages and consequences of using PLGA in 3D printing technology to improve bone tissue engineering clinical outcomes.","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1611-1637"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The application progress of PAMAM dendrimer in cancer imaging and treatment. PAMAM树突状分子在肿瘤成像与治疗中的应用进展。

IF 3.6 4区医学

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-04-28 DOI: 10.1080/09205063.2025.2497623

Cong-Ying Zhang, Kai Gu, Meng-Yi Chi, Xiao-Yan Gao, Ling Gao, Nan-Nan Zhang, Yu-Xi Liu, Tian-Zhu Li

引用次数: 0