Journal of Biomaterials Science, Polymer Edition最新文献

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The application progress of PAMAM dendrimer in cancer imaging and treatment. PAMAM树突状分子在肿瘤成像与治疗中的应用进展。
IF 3.6 4区 医学
Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-04-28 DOI: 10.1080/09205063.2025.2497623
Cong-Ying Zhang, Kai Gu, Meng-Yi Chi, Xiao-Yan Gao, Ling Gao, Nan-Nan Zhang, Yu-Xi Liu, Tian-Zhu Li
{"title":"The application progress of PAMAM dendrimer in cancer imaging and treatment.","authors":"Cong-Ying Zhang, Kai Gu, Meng-Yi Chi, Xiao-Yan Gao, Ling Gao, Nan-Nan Zhang, Yu-Xi Liu, Tian-Zhu Li","doi":"10.1080/09205063.2025.2497623","DOIUrl":"10.1080/09205063.2025.2497623","url":null,"abstract":"<p><p>Polyamidoamine dendrimer (PAMAM) are effective carriers that transport diagnostic imaging reagents and drugs to the tumor site. Their excellent bio-compatibility and bio-degradability reduce damage to healthy tissues, resulting in improved treatment efficacy. Dendrimer molecules are particularly useful in targeted drug delivery within malignant cells. This article reviews recent progress of PAMAM in imaging and treating breast cancer, lung cancer, hepatocellular cancer, colorectal cancer, gastric cancer, prostate cancer, and glioblastoma. This review aims to provide new and feasible ideas for cancer diagnosis imaging and treatment while also serving as a significant reference point for personalized tumor therapy based on PAMAM materials.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1638-1675"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Whitlockite nanoparticles incorporated chitin-poly(dioxanone) composite scaffold for alveolar bone regeneration. Whitlockite纳米颗粒结合几丁质-聚二恶酮复合支架用于牙槽骨再生。
IF 3.6 4区 医学
Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-02-07 DOI: 10.1080/09205063.2025.2460377
Kavipriya Murugaiyan, Arthi Chandramouli, Jayakumar Rangasamy
{"title":"Whitlockite nanoparticles incorporated chitin-poly(dioxanone) composite scaffold for alveolar bone regeneration.","authors":"Kavipriya Murugaiyan, Arthi Chandramouli, Jayakumar Rangasamy","doi":"10.1080/09205063.2025.2460377","DOIUrl":"10.1080/09205063.2025.2460377","url":null,"abstract":"<p><p>Loss of alveolar bone due to periodontitis is prevalent among a wide range of population and is a major concern for oral health. Treatment of alveolar bone loss is aimed based on the repair of the periodontium as well as type of defect that has been formed. Nanocomposite based hydrogel and scaffolds for alveolar bone regeneration has gained significant attention due to their favourable properties such as stability, biocompatibility and enhanced regeneration. Chitin has been used for decades in biomedical applications owing to its good biological activity, biocompatibility and biodegradability. The addition of synthetic polymer such as polydiaxanone into chitin alters the degradation properties and also enhances the biological properties such as osteogenesis. The addition of bioceramic, whitlockite nanoparticles induces mineralization and osteogenesis. Thus, we developed a composite scaffold (Ch-PDO-nWH) using chitin, polydioxanone and whitlockite nanoparticles, a magnesium based bioceramic. The prepared Ch-PDO-nWH composite scaffold is porous in nature, with swelling property and controlled degradation. The scaffold was tested for its biocompatibility using dental follicle stem cells (DFSCs) which showed improved biocompatibility, biomineralization and also stimulated the expression of osteogenic markers such as RUNX2 and OPN thus ultimately aiding in bone regeneration.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1677-1693"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the efficacy of polyvinyl alcohol/chitosan nanofibrous mat loaded with myrtle essential oil/gum Arabic in wound healing. 评价载桃金娘精油/阿拉伯胶聚乙烯醇/壳聚糖纳米纤维垫在伤口愈合中的效果。
IF 3.6 4区 医学
Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-03-13 DOI: 10.1080/09205063.2025.2476288
Fateme Sanati, Mansoureh Ashghali Farahani, Mohammad Reza Rostami-Darounkola, Fatemeh Shokrolahi, Mohsen Naseri
{"title":"Assessing the efficacy of polyvinyl alcohol/chitosan nanofibrous mat loaded with myrtle essential oil/gum Arabic in wound healing.","authors":"Fateme Sanati, Mansoureh Ashghali Farahani, Mohammad Reza Rostami-Darounkola, Fatemeh Shokrolahi, Mohsen Naseri","doi":"10.1080/09205063.2025.2476288","DOIUrl":"10.1080/09205063.2025.2476288","url":null,"abstract":"<p><p>Nowadays, extensive research has been conducted on electrospun nanofibers for wound dressing applications. Considering the growing concern over bacterial resistance to common antibiotics, investigating the potential of natural essential oils with antibacterial properties could prove to be beneficial in addressing this issue. In response to the challenges posed by impaired wound healing, we have designed a novel electrospun polyvinyl alcohol/chitosan nanofiber embedded with myrtle essential oil and gum Arabic dispersion (PVA/CS/MT-GA). The morphology and molecular structure of the prepared nanofibers were evaluated by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) analysis. The synthesized PVA/CS/MT-GA composite demonstrated a remarkable swelling capacity of 744% and exhibited acceptable mechanical strength. Additionally, the water vapor transmission rate (WVTR) of these nanofibers was obtained as 2497 g.m<sup>-2</sup>.day<sup>-1</sup>, which falls within the ideal range for wound dressings. The antimicrobial test results revealed that PVA/CS/MT-GA nanofibers exhibited notable antibacterial properties when tested against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. The release profile of MT from MT-containing nanofibers exhibited a burst release mechanism in PVA/CS/MT-GA nanofibers, which can be beneficial in applications that require an immediate therapeutic effect. Furthermore, nanofibers as wound dressings in the full-thickness wound model of Wistar rats demonstrated a remarkable capacity to care for damaged tissue and promote faster healing times. Collectively, the results obtained in this study suggest that the developed nanofiber holds great promise as a potential candidate for wound dressing applications.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1769-1790"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An update on implication of POSS-based nanocomposites in bone tissue engineering: a review. 基于poss的纳米复合材料在骨组织工程中的应用进展
IF 3.6 4区 医学
Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-02-18 DOI: 10.1080/09205063.2025.2455234
Leyla Bagheri, Davoud Jafari-Gharabaghlou, Mohammad-Reza Dashti, Nosratollah Zarghami
{"title":"An update on implication of POSS-based nanocomposites in bone tissue engineering: a review.","authors":"Leyla Bagheri, Davoud Jafari-Gharabaghlou, Mohammad-Reza Dashti, Nosratollah Zarghami","doi":"10.1080/09205063.2025.2455234","DOIUrl":"10.1080/09205063.2025.2455234","url":null,"abstract":"<p><p>The science of Bone tissue engineering (TE) is quickly progressing. Engineering bone usually applications a synthetic extracellular matrix, cells or osteoblasts that can convert to osteoblasts, and adjusting causes that boost adhesion, distinction, and mineralized bone construction of cells. Extremely porous scaffolds perform an important character in cell planting, propagation, and fresh 3D-tissue construction. Reformative medicine and tissue engineering track a multi-disciplinary approach for the novel substances' development and appliance, to the various tissue defects therapy. The presentation of polyhedral oligomeric silsesquioxane (POSS) in the bio-polymeric scaffold has been shown to develop the biotic attributes of the hybrid combinations. This review focuses on the influence of POSS within the Chitosan (CS), Hydroxyapatite (HA), and zeolite matrixes, scaffold drawing, and the advantages and limitations of the materials mentioned for tissue engineering of bone.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1587-1610"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D printed gastroretentive floating-hollow capsular device (GRF-HCD) for levofloxacin oral delivery using selective laser sintering (SLS) platform technology. 采用选择性激光烧结(SLS)平台技术的3D打印左氧氟沙星口服胃保留漂浮中空胶囊装置(GRF-HCD)
IF 3.6 4区 医学
Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-02-03 DOI: 10.1080/09205063.2025.2458841
Ganesh Pandav, Tukaram Karanwad, Subham Banerjee
{"title":"3D printed gastroretentive floating-hollow capsular device (GRF-HCD) for levofloxacin oral delivery using selective laser sintering (SLS) platform technology.","authors":"Ganesh Pandav, Tukaram Karanwad, Subham Banerjee","doi":"10.1080/09205063.2025.2458841","DOIUrl":"10.1080/09205063.2025.2458841","url":null,"abstract":"<p><p>The development of gastroretentive drug delivery systems is one such instance, which was developed to improve the oral bioavailability and effectiveness of drugs, which has a poor absorption window in the upper GIT and/or triggers local activity such as duodenal and stomach activity. In this work, the objective of sintering gastroretentive dosage forms was to sustain the release of levofloxacin in the gastric region for an extended period of time. Selective laser sintering (SLS)-mediated powder bed fusion 3D printing technology was utilized to design and fabricate a modified-release gastroretentive floating-hollow capsular device (GRF-HCD) in three distinct capsule sizes namely, 000, 00, and 0 with the aid of pharmaceutical grade polymers (combinations of Kolliphor P188 and Kollidon SR in 1:1 ratio). Sintered GRF-HCD was further subjected to morphological analysis, weight variation, and swelling index. In addition, <i>in vitro</i> and <i>in vivo</i> buoyancy studies were performed in an animal model using X-ray imaging. Finally, the <i>in vitro</i> drug release from GRF-HCD was performed in simulated gastric pH condition (pH-1.2) upto 12 h. Levofloxacin concentration was then quantified using validated RP-HPLC method. The <i>in vitro</i> floating behaviour was mimicked with the <i>in vivo</i> floating, where the GRF-HCD was retained in the rabbit stomach for an extended period which will help to sustain the drug release for a longer period and maintained the maximum concentration of levofloxacin in the gastric region.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1547-1564"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A multifunctional biomimetic double-layer composite hydrogel with wet adhesion and antioxidant activity for dural repair. 一种用于硬脑膜修复的具有湿粘附和抗氧化活性的多功能仿生双层复合水凝胶。
IF 3.6 4区 医学
Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-02-10 DOI: 10.1080/09205063.2025.2460373
Shui Guan, Chang Sun, Chuzhou Wen, Bing Yao, Jianqiang Xu, Changkai Sun
{"title":"A multifunctional biomimetic double-layer composite hydrogel with wet adhesion and antioxidant activity for dural repair.","authors":"Shui Guan, Chang Sun, Chuzhou Wen, Bing Yao, Jianqiang Xu, Changkai Sun","doi":"10.1080/09205063.2025.2460373","DOIUrl":"10.1080/09205063.2025.2460373","url":null,"abstract":"<p><p>Cerebrospinal fluid (CSF) leakage caused by accidents or diseases resulting from traumatic brain injury, inflammation, tumor erosion and surgery can lead to many complications. In this study, a multifunctional composite double-layer hydrogel was designed by simulating the structure of native dura mater, which was composed of polyacrylic acid (PAA), polyethyleneimine (PEI), sodium alginate (SA), β-cyclodextrin (β-CD) and edaravone (Ed). The PAA/PEI layer had strong wet adhesion characteristics, while the PEI/SA@β-CD/Ed layer exhibited significant antioxidant, drug release and biocompatibility properties. By controlling the concentration of Ca<sup>2+</sup>, the gelation time can be adjusted rapidly within 95-215 s. Specifically, the final PAA/PEI/SA@β-CD/Ed composite hydrogel exhibited a porous network structure with high porosity and low swelling rate, improved tensile strength, sufficient biodegradability, favourable adhesion performance, enhanced DPPH and ABTS radicals scavenging abilities, and sustained Ed release capacity. In addition, the resulting hydrogel also showed excellent biocompatibility and protective effect on H<sub>2</sub>O<sub>2</sub>-induced oxidative damage in SH-SY5Y cells. These results preliminarily suggested that the PAA/PEI/SA@β-CD/Ed composite hydrogel would appear to be a promising candidate for dural repair.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1565-1586"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of electric fields on the modulation of chondrocytes dynamics in gelatin scaffolds: a novel approach to optimize cartilage tissue engineering. 电场对明胶支架中软骨细胞动力学调节的影响:一种优化软骨组织工程的新方法。
IF 3.6 4区 医学
Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-02-25 DOI: 10.1080/09205063.2025.2466971
Juan José Saiz Culma, Johana María Guevara Morales, Yoshie Adriana Hata Uribe, Diego Alexander Garzón-Alvarado, Sara Leal-Marin, Birgit Glasmacher, Juan Jairo Vaca-González
{"title":"Effects of electric fields on the modulation of chondrocytes dynamics in gelatin scaffolds: a novel approach to optimize cartilage tissue engineering.","authors":"Juan José Saiz Culma, Johana María Guevara Morales, Yoshie Adriana Hata Uribe, Diego Alexander Garzón-Alvarado, Sara Leal-Marin, Birgit Glasmacher, Juan Jairo Vaca-González","doi":"10.1080/09205063.2025.2466971","DOIUrl":"10.1080/09205063.2025.2466971","url":null,"abstract":"<p><p>The treatment of degenerative pathologies affecting articular cartilage remains a significant clinical challenge. Non-invasive biophysical stimuli, such as electric fields, have demonstrated potential as therapeutic tools for cartilage tissue restoration. Previous studies have reported that electric fields enhance chondrocyte proliferation and the synthesis of key extracellular matrix components, such as glycosaminoglycans. However, inconsistencies in experimental designs have led to variable findings. This study examines the effects of capacitively coupled electric fields on chondrocytes cultured in gelatin hydrogels. Alternating voltages of 50 V (7.7 mV/cm) and 100 V (8.7 mV/cm) at a frequency of 60 kHz were applied for 21 days. Cell quantification and glycosaminoglycan analysis were performed on both stimulated and control samples. On day 7, exposure to the electric field resulted in a significant reduction in cell proliferation by 24.7% and 39.2% at 7.7 mV/cm and 8.7 mV/cm, respectively (<i>p</i> < 0.05). However, stimulation at 8.7 mV/cm led to a 35.7% increase in glycosaminoglycan synthesis compared to the control group (<i>p</i> < 0.05). These findings indicate that electric field stimulation can modulate the synthesis of essential extracellular matrix components, such as glycosaminoglycans, in hyaline cartilage. This highlights the potential of electric fields as a promising strategy to enhance outcomes in articular cartilage tissue engineering, particularly in hydrogel-based therapeutic approaches.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1749-1768"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Near-infrared photothermal silk fibroin/polydopamine nanospheres with incorporated silver nanoparticles for efficient antibacterial application. 含银纳米粒子的近红外光热丝素/聚多巴胺纳米球具有高效抗菌应用。
IF 3.6 4区 医学
Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-02-10 DOI: 10.1080/09205063.2025.2457265
Liwen Yang, Kai Zou, Shanshan Li, Liu Huang, Kairui Guo, Zihong Feng, Yi Liu, Wei Liu
{"title":"Near-infrared photothermal silk fibroin/polydopamine nanospheres with incorporated silver nanoparticles for efficient antibacterial application.","authors":"Liwen Yang, Kai Zou, Shanshan Li, Liu Huang, Kairui Guo, Zihong Feng, Yi Liu, Wei Liu","doi":"10.1080/09205063.2025.2457265","DOIUrl":"10.1080/09205063.2025.2457265","url":null,"abstract":"<p><p>Bacterial infections and the emergence of drug-resistant after the misuse of antibiotics are threats to human health worldwide. Photothermal nanomaterials incorporating metallic antibacterial agents offer a promising solution. Herein, an antibacterial nanocomposite (Ag@SF@PDA) comprising silver nanoparticles (AgNPs) with silk fibroin/polydopamine nanospheres (SF@PDA) was designed for efficient antibacterial application. Specifically, AgNPs were reduced <i>in situ</i> by polydopamine and encapsulated in the polydopamine outer layer. The Ag@SF@PDA, with a diameter of about 144.7 nm, had a spherical shape and a rough surface. Under 808 nm, 1.5 W/cm<sup>2</sup> NIR near-infrared (NIR) irradiation, Ag@SF@PDA demonstrated excellent photothermal performance and stability, reaching a maximum temperature of 56.8 °C after 12 min. Their photothermal performance was improved as the concentration increased. The viability results of L929 fibroblasts <i>in vitro</i> demonstrated that Ag@SF@PDA had good biocompatibility. Even when the concentration was increased to 0.5 mg/mL, the cells still maintained their viability. Of note, Ag@SF@PDA exhibited remarkably high antibacterial efficacies against both <i>Staphylococcus aureaus</i> and <i>Escherichia coli</i> after NIR irradiation. Their antibacterial efficacies were above 99.9% under NIR irradiation and comparable to those of ampicillin. These photothermal nanospheres have a great potential in efficient antibacterial application.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1529-1546"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing antioxidant-antimicrobial nanofibers containing Corallina officinalis extract for wound healing. 含有珊瑚提取物的抗氧化-抗菌纳米纤维用于伤口愈合。
IF 3.6 4区 医学
Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-31 DOI: 10.1080/09205063.2025.2537744
Ahmed Mostafa Fahmy, Amel M Soliman, Sohair R Fahmy, Sara Bayoumi Ali, Shimaa A Sadek
{"title":"Developing antioxidant-antimicrobial nanofibers containing <i>Corallina officinalis</i> extract for wound healing.","authors":"Ahmed Mostafa Fahmy, Amel M Soliman, Sohair R Fahmy, Sara Bayoumi Ali, Shimaa A Sadek","doi":"10.1080/09205063.2025.2537744","DOIUrl":"10.1080/09205063.2025.2537744","url":null,"abstract":"<p><p>The growing global demand for wound care has revealed the limitations of traditional dressings, particularly their insufficient antimicrobial and antioxidant properties. This study aims to develop a natural-based nanofibrous dressing that improves wound dressing effectiveness by addressing challenges such as antimicrobial activity and moisture regulation. The research focuses on developing antimicrobial and antioxidant mats using chitosan, polyvinyl alcohol (PVA), and crude <i>Corallina officinalis</i> extract (COE) <i>via</i> electrospinning. A comprehensive evaluation assessed their morphology, structure, mechanical properties, wettability, biodegradation rate, and biological activities. FTIR spectroscopy confirmed the integration of all components, while SEM analysis showed bead-free nanofibers with a diameter of 230 ± 5.57 nm, significantly enhancing mechanical strength from 6.62 ± 0.04 MPa to 7.34 ± 0.03 MPa. Adding 3% COE preserved ideal hydrophilicity, biodegradation rates, and swelling index for tissue regeneration. Antibacterial tests showed a zone of inhibition measuring 28.00 ± 0.10 mm against <i>Escherichia coli</i> and 22.00 ± 0.20 mm against <i>Staphylococcus aureus</i> when using a 3% concentration of COE. Additionally, the fabricated dressings effectively prevented bacterial penetration, resulting in negligible colony growth in the culture media. The present study demonstrated that nanofiber dressings significantly enhance the biological activities of COE, particularly its antioxidant and anti-inflammatory effects. Moreover, the COE and CS/PVA/COE nanofiber mats exhibit excellent biocompatibility and low cytotoxicity, promoting skin cell survival and proliferation. So, this research highlights the promising potential of COE-enriched nanofibers in advanced wound care applications.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-39"},"PeriodicalIF":3.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the influence of human serum albumin on the degradation behavior of PLA films produced with green solvent. 解码人血清白蛋白对绿色溶剂制备的聚乳酸薄膜降解行为的影响。
IF 3.6 4区 医学
Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-27 DOI: 10.1080/09205063.2025.2535736
Ester Escalera-Rota, Margarita Hierro-Oliva, M Luisa González-Martín, Amparo María Gallardo-Moreno
{"title":"Decoding the influence of human serum albumin on the degradation behavior of PLA films produced with green solvent.","authors":"Ester Escalera-Rota, Margarita Hierro-Oliva, M Luisa González-Martín, Amparo María Gallardo-Moreno","doi":"10.1080/09205063.2025.2535736","DOIUrl":"https://doi.org/10.1080/09205063.2025.2535736","url":null,"abstract":"<p><p>Polylactic acid (PLA) is gaining prominence in biomedical fields due to its favorable physicochemical characteristics, such as biodegradability and biocompatibility. This study investigates the degradation behavior of PLA films fabricated with dimethyl carbonate, a green solvent alternative to traditional chloroform, and sterilized <i>via</i> UV-C irradiation. Two degradation pathways were examined: exposure to ultraviolet radiation (photodegradation) and immersion in a simulated body fluid (<i>m-</i>SBF) buffer (physiodegradation), with and without human supplementation of serum albumin (HSA). Surface properties such as zeta potential, hydrophobicity, surface tension, and chemical composition were evaluated before and after degradation. Prolonged UV-C photodegradation resulted in chemical activation of the surface, which modulated subsequent interactions with the physiological environment. More specifically, an increase of the negative surface charge and a slight reduction of the surface free energy were observed. Photodegradation enhanced subsequent physiodegradation, as evidenced by greater surface polarity and ion adsorption. Immersion in <i>m-</i>SBF led to increased hydrophilicity, while HSA presence during immersion influenced the formation of biointerfacial layers, markedly shifting the surface to a superhydrophilic and nearly neutral electrical state. Analytical techniques such as time-of-flight secondary ion mass spectrometry identified the presence of nitrogen-containing fragments indicative of protein attachment. Notably, UV-C exposure reduced protein adsorption, suggesting changes in surface affinity.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-20"},"PeriodicalIF":3.6,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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