PAMAM树突状分子在肿瘤成像与治疗中的应用进展。

IF 3.6 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-08-01 Epub Date: 2025-04-28 DOI:10.1080/09205063.2025.2497623

Cong-Ying Zhang, Kai Gu, Meng-Yi Chi, Xiao-Yan Gao, Ling Gao, Nan-Nan Zhang, Yu-Xi Liu, Tian-Zhu Li

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引用次数: 0

摘要

聚酰胺胺树突状分子（PAMAM）是将诊断成像试剂和药物运送到肿瘤部位的有效载体。其优异的生物相容性和生物降解性减少了对健康组织的损伤，从而提高了治疗效果。树突分子在恶性细胞内的靶向药物递送中特别有用。本文综述了PAMAM在乳腺癌、肺癌、肝细胞癌、结直肠癌、胃癌、前列腺癌和胶质母细胞瘤的成像和治疗方面的最新进展。本综述旨在为肿瘤的诊断、成像和治疗提供新的可行思路，同时也为基于PAMAM材料的肿瘤个性化治疗提供重要参考点。

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The application progress of PAMAM dendrimer in cancer imaging and treatment.

Polyamidoamine dendrimer (PAMAM) are effective carriers that transport diagnostic imaging reagents and drugs to the tumor site. Their excellent bio-compatibility and bio-degradability reduce damage to healthy tissues, resulting in improved treatment efficacy. Dendrimer molecules are particularly useful in targeted drug delivery within malignant cells. This article reviews recent progress of PAMAM in imaging and treating breast cancer, lung cancer, hepatocellular cancer, colorectal cancer, gastric cancer, prostate cancer, and glioblastoma. This review aims to provide new and feasible ideas for cancer diagnosis imaging and treatment while also serving as a significant reference point for personalized tumor therapy based on PAMAM materials.

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来源期刊

Journal of Biomaterials Science, Polymer Edition 工程技术-材料科学：生物材料

CiteScore

7.10

自引率

5.60%

发文量

117

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels. The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.