Biocompatible PLA/spirulina microparticles via electrospraying for targeted drug delivery in HUVEC and HaCaT cell lines.

IF 3.6 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-05-27 DOI:10.1080/09205063.2025.2503928

Basak Dalbayrak, Isil Aksan Kurnaz, Sumeyye Cesur, Oguzhan Gunduz, Elif Damla Arısan

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引用次数: 0

Abstract

Spirulina platensis, well-known for its abundant nutrients and sustainability, shows potential as a microcarrier for various biotechnological uses. However, its natural degradability presents a challenge. Polylactic Acid (PLA) offers a solution due to its biodegradability and compatibility. By using the electrohydrodynamic atomization technique (electrospraying), precise control over microparticle characteristics like size, shape, and composition is achieved by adjusting parameters such as voltage, flow rate, and solution properties. In this research, microparticles made from Spirulina extract and PLA were created through electrospraying to act as microcarriers. Different formulations were tested, including 3% PLA and blends of Spirulina extract and PLA at concentrations of 0.125%, 0.25%, and 0.5% using chloroform and ethanol in the ratio of 19:1. Through various tests (MTT assay and colony formation test) the biocompatibility of producing microparticles was assessed using HUVEC and HaCaT cell lines, indicating these microparticles' potential for diverse applications as microcarrier systems.

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生物相容性聚乳酸/螺旋藻微粒电喷涂在HUVEC和HaCaT细胞中的靶向药物递送。

螺旋藻以其丰富的营养和可持续性而闻名，显示出作为各种生物技术用途的微载体的潜力。然而，它的自然降解性提出了一个挑战。聚乳酸（PLA）由于其可生物降解性和相容性提供了一种解决方案。通过使用电流体动力雾化技术（电喷涂），通过调整电压、流量和溶液性质等参数，可以精确控制微粒的大小、形状和组成等特性。本研究以螺旋藻提取物和聚乳酸为原料，采用电喷涂法制备微颗粒作为微载体。以氯仿和乙醇为原料，将螺旋藻提取物与PLA分别以0.125%、0.25%和0.5%的浓度混合，以19:1的比例进行配方试验。通过各种测试（MTT试验和菌落形成试验），利用HUVEC和HaCaT细胞系评估了生产微颗粒的生物相容性，表明这些微颗粒作为微载体系统具有多种应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomaterials Science, Polymer Edition 工程技术-材料科学：生物材料

CiteScore

7.10

自引率

5.60%

发文量

117

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels. The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.