Advancements in cartilage tissue regeneration: harnessing nano- and microtechnology for enhanced mesenchymal stem cells delivery in osteoarthritis treatment.

IF 3.6 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-09-15 DOI:10.1080/09205063.2025.2555736

Ayush Rohila, Kailash Ahirwar, Rahul Shukla

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引用次数: 0

Abstract

Osteoarthritis (OA), a debilitating condition linked to aging and injury, lacks effective treatments due to limited cartilage repair. Conventional methods often fall short, prompting exploration of innovative solutions. Mesenchymal stem cell (MSC) therapy exhibits potential in the treatment of OA by stimulating the growth of new cartilage and diminishing inflammation. However, limited cell survival and retention hinder its effectiveness. Nano- and microcarrier technology offers a groundbreaking approach. By encapsulating and delivering MSCs, these biomaterial-based carriers improve cell viability and targeted delivery. This review explores recent advancements in nano- and microcarriers, highlighting their potential to overcome limitations of traditional delivery methods in OA therapy. It delves into how these advanced systems facilitate targeted MSC delivery, paving the way for a revolution in cartilage regeneration. By providing a comprehensive understanding of the current state of MSC-based therapy and its synergy with advanced delivery platforms, this review emphasizes the potential of nano- and microcarriers for efficient and long-lasting OA treatment.

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软骨组织再生的进展：利用纳米和微技术增强骨关节炎治疗中的间充质干细胞输送。

骨关节炎（OA）是一种与衰老和损伤有关的衰弱疾病，由于软骨修复有限，缺乏有效的治疗方法。传统的方法往往达不到要求，促使人们探索创新的解决方案。间充质干细胞（MSC）疗法通过刺激新软骨的生长和减少炎症，显示出治疗OA的潜力。然而，有限的细胞存活和保留阻碍了其有效性。纳米和微载体技术提供了一种突破性的方法。通过包封和递送MSCs，这些基于生物材料的载体提高了细胞活力和靶向递送。本文综述了纳米和微载体的最新进展，强调了它们在OA治疗中克服传统递送方法局限性的潜力。它深入研究了这些先进的系统如何促进有针对性的MSC递送，为软骨再生的革命铺平了道路。通过全面了解基于msc的治疗现状及其与先进给药平台的协同作用，本综述强调了纳米和微载体在有效和持久OA治疗中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomaterials Science, Polymer Edition 工程技术-材料科学：生物材料

CiteScore

7.10

自引率

5.60%

发文量

117

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels. The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.