Janus-loaded Zn²⁺ composite film dressing based on chitin from Periplaneta americana effectively promotes wound healing.

IF 3.6 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Science, Polymer Edition Pub Date : 2025-07-10 DOI:10.1080/09205063.2025.2524871

Yang Qing, Ailian Zhu, Ling He, Hujing Zhang, Xi Wang, Chunyan Xiao, Qiang Fu, Qin Song

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引用次数: 0

Abstract

This study compared the application-specific benefits of PAC (Periplaneta americana chitin) and SC (Shrimp chitin) blended with PEG (Polyethylene Glycol) in innovative wound-dressing materials. By preparing SC/PEG and PAC/PEG porous blended membranes, it was found that PAC/PEG has better breathability, degradability. Based on this, we developed a Janus PAC/PEG@Zn0.3 composite film dressing for wound healing. After crosslinking PAC with PEG, a hydrophilic layer was formed through phase separation and selective dissolution, loaded with Zn²⁺, and combined with a hydrophobic PCL (Polycaprolactone) membrane using a simple coating technique. This composite film has the characteristics of being moist, breathable, and stretchable, and exhibits good biodegradability and compatibility. The addition of Zn²⁺ enhanced the hemostatic and antibacterial properties of the film. The mouse wound healing experiment showed that the dressing promoted collagen deposition and capillary generation, accelerating wound healing. Overall, the Janus PAC/PEG@Zn0.3 composite film is a wound dressing with promising application prospects.

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基于美洲大蠊甲壳素的负载Zn2+复合膜敷料能有效促进伤口愈合。

本研究比较了PAC（美洲大蠊甲壳素）和SC（虾甲壳素）与PEG（聚乙二醇）混合在新型创面敷料中的应用效益。通过制备SC/PEG和PAC/PEG多孔共混膜，发现PAC/PEG具有更好的透气性、可降解性。在此基础上，我们开发了Janus PAC/PEG@Zn0.3复合膜敷料用于伤口愈合。PAC与PEG交联后，通过相分离和选择性溶解形成亲水层，负载Zn2+，并通过简单的包覆技术与疏水PCL（聚己内酯）膜结合。该复合膜具有湿润、透气、可拉伸的特点，并具有良好的生物降解性和相容性。Zn2+的加入增强了膜的止血和抗菌性能。小鼠创面愈合实验表明，该敷料促进胶原沉积和毛细血管生成，促进创面愈合。总之，Janus PAC/PEG@Zn0.3复合膜是一种具有良好应用前景的伤口敷料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomaterials Science, Polymer Edition 工程技术-材料科学：生物材料

CiteScore

7.10

自引率

5.60%

发文量

117

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels. The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.