Journal of biomechanics最新文献

{"title":"Impact of adjustable dorsiflexion range and stiffness in articulated ankle–foot orthosis on center of pressure progression in post-stroke gait","authors":"Toshiki Kobayashi ,&nbsp;Yufan He ,&nbsp;Chloe L.Y. Wong ,&nbsp;Mark W.P. Koh ,&nbsp;Abu Jor ,&nbsp;Michael S. Orendurff ,&nbsp;Fan Gao","doi":"10.1016/j.jbiomech.2026.113188","DOIUrl":"10.1016/j.jbiomech.2026.113188","url":null,"abstract":"<div><div>A multi-function articulated ankle–foot orthosis (AFO) allows independent adjustment of dorsiflexion and plantarflexion range of motion (ROM) and stiffness to optimize gait performance in individuals post-stroke. This study investigated the effects of varying two parameters of an articulated AFO (dorsiflexion ROM and stiffness) on center of pressure (CoP) trajectories, plantar forces, and spatiotemporal parameters during treadmill walking in 10 individuals post-stroke. After individualized tuning of the plantarflexion settings, dorsiflexion ROM was set at 0°, 5°, and 10° using the Triple Action joint under two dorsiflexion joint stiffness conditions: low (0.44 Nm/deg) and high (1.13 Nm/deg). Gait data were acquired using a Zebris FDM-T instrumented treadmill across six dorsiflexion joint configurations. A two-way repeated measures ANOVA was used to evaluate the main and interaction effects of ROM and stiffness on gait parameters (CoP, plantar forces, and spatiotemporal) in both paretic and non-paretic limbs, as well as on their symmetry indices. Significant main effects of dorsiflexion ROM were observed for the length of the single support line and its symmetry (p = 0.012; p = 0.023), as well as for maximum forefoot loading (p = 0.012) in the non-paretic limb. Dorsiflexion stiffness also significantly affected the length of the gait line (p = 0.037) and loading response time (p = 0.021) in the non-paretic limb. These findings suggest that adjustments to dorsiflexion ROM and stiffness in an articulated AFO induce measurable biomechanical adaptations in the contralateral non-paretic limb. The results highlight the importance of individualized AFO tuning and bilateral gait assessment in post-stroke rehabilitation to enhance gait symmetry and overall performance.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"198 ","pages":"Article 113188"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying the most prominent transversal gait patterns in children with torsional deformities using cluster analysis","authors":"Nathalie Alexander ,&nbsp;Florian Dobler ,&nbsp;Djordje Slijepčević","doi":"10.1016/j.jbiomech.2026.113194","DOIUrl":"10.1016/j.jbiomech.2026.113194","url":null,"abstract":"<div><div>Several studies examined specific torsional deformities and correlations between imaging and 3D gait analysis. However, an overview of common gait patterns in combination with computer tomography-verified torsional profiles is currently lacking. The aim of the current study was to identify the most prominent gait patterns in children with torsional deformities. Pediatric patients (n = 165), who were referred to gait analysis and computer tomography to evaluate torsional deformities, were included in this retrospective study (exclusion: any neurological diseases). Kinematics of the more affected leg were analyzed. Transversal joint angles during stance were used for clustering. After identifying the optimal number of clusters, kinematics across the gait cycle and anthropometrics were compared between clusters and typically developing children (n = 46; 11.8 ± 3.3 years) using one-way ANOVA (α = 0.05) with Bonferroni corrected post-hoc tests (α = 0.005). Four distinct clusters were identified: C1 (n = 44; 13.8 ± 1.6 years, BMI: 19.2 ± 2.4, f/m: 23/21) – functional malalignment group with excessive external tibial torsion; C2 (n = 26; 12.6 ± 1.4 years, BMI: 24.6 ± 6.0, f/m: 5/21) – reverse malalignment group characterized by high hip external rotation and low tibial torsion; C3 (n = 35; 12.9 ± 1.3 years, BMI: 18.6 ± 2.9, f/m: 22/13) – in-toeing group (tendencies to higher hip internal rotation); C4 (n = 60; 13.3 ± 1.8 years, BMI: 23.0 ± 5.0 years, f/m: 8/52) – decreased femoral torsion group. Comparison of gait kinematics and torsion values showed some C1 patients compensated with internal hip rotation, while some C2 patients compensated with external hip rotation. Transversal gait patterns were only partially explained by torsional profiles from imaging highlighting the need to consider individual gait kinematics when treating these patients.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"197 ","pages":"Article 113194"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative tensile properties of the equine vagina, penile sheath, and scrotum","authors":"Angel E. Collins ,&nbsp;Jennifer S. Wayne ,&nbsp;Cecile A. Ferrando ,&nbsp;Raffaella De Vita","doi":"10.1016/j.jbiomech.2026.113169","DOIUrl":"10.1016/j.jbiomech.2026.113169","url":null,"abstract":"<div><div>This experimental study characterizes the elastic behavior of male and female equine genital tissues using uniaxial tensile testing, with strain measurements obtained via digital image correlation. Dog-bone-shaped tissue specimens were excised from mares and geldings (<span><math><mi>n</mi><mo>=</mo><mn>23</mn></math></span> from female specimens and <span><math><mi>n</mi><mo>=</mo><mn>42</mn></math></span> from male specimens) with all specimens aligned along the circumferential direction (CD) of the vagina, penis, and scrotum. The results include load-displacement data, stress–strain data, and tangent moduli for the penile sheath, vaginal canal, and scrotum, with strain measured in both the CD and the longitudinal direction (LD). Findings indicate that vaginal and scrotal tissues exhibit comparable mechanical properties (tangent moduli: 10.16 <span><math><mo>±</mo></math></span> 1.30 MPa for the vagina and 4.81 <span><math><mo>±</mo></math></span> 1.66 MPa for the scrotum), whereas the penile sheath (tangent modulus: 2.30 <span><math><mo>±</mo></math></span> 1.43 MPa) differs significantly from the vaginal and scrotal tissues (<span><math><mi>p</mi><mo>&lt;</mo><mn>0.01</mn></math></span> and <span><math><mi>p</mi><mo>&lt;</mo><mn>0.05</mn></math></span>, respectively). This mechanical evaluation of vaginal, penile, and scrotal tissues has implications for advancing surgical techniques, developing genital prostheses, and informing biomechanical models of the pelvic region.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"197 ","pages":"Article 113169"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial neural networks for predicting ground reaction forces, feet centers of pressure, spine loads, and trunk muscle forces during load-handling activities","authors":"S.N. Hosseini,&nbsp;S. Daroudi,&nbsp;M. Mohseni,&nbsp;N. Arjmand","doi":"10.1016/j.jbiomech.2026.113190","DOIUrl":"10.1016/j.jbiomech.2026.113190","url":null,"abstract":"<div><div>Excessive spinal loading is a key contributor to occupational musculoskeletal injuries. Numerous biomechanical models, ranging from simple to highly sophisticated, are available to evaluate these loads. While simple models often lack accuracy, advanced ones are too complex for practical uses. We aim to develop a set of easy-to-use artificial neural networks (ANNs) that replicate the outputs of a detailed musculoskeletal model, i.e., AnyBody Modeling System (AMS). Kinematics data were collected from 20 participants each performing 204 load-handling tasks, combined with 9 hand-load magnitudes, resulting in 36,720 simulated tasks in AMS. The ANNs were trained to map inputs (hand-load position and magnitude, body weight and height, lifting-technique, and handling-technique) to AMS outputs (T12-S1 spine loads, trunk muscle forces, ground reaction forces (GRFs), and feet centers of pressure (CoPs)). The ANNs demonstrated good-to-excellent predictive performance, with normalized-root-mean-squared-errors (nRMSEs) ranging from 2.6% to 11.2% and (R²) between 0.59 and 0.97. The ANNs for compressive and anteroposterior shear loads, vertical GRFs and CoPs (2.6% &lt; nRMSEs &lt; 6.4% and 0.88 &lt; R² &lt; 0.97) outperformed those for horizontal GRFs and mediolateral shear loads (7.2% &lt; nRMSEs &lt; 9.9% and 0.59 &lt; R² &lt; 0.68). Among the predicted muscle forces, the erector spinae exhibited the lowest error (nRMSE = 6.8%, R² = 0.88), followed by the external oblique (nRMSE = 8.0%, R² = 0.84) and the multifidus (nRMSE = 8.2%, R² = 0.81). External validation on two unseen subjects demonstrated good generalization of the proposed ANNs, with strong agreement for CoPs, vertical GRFs, and lumbar anteroposterior shear loads (R² ≈ 0.86–0.93; nRMSE ≈ 4.8–7.1%), while acceptable performance was observed for major trunk muscle forces (R² ≈ 0.57–0.77). These findings suggest that ANNs offer promising alternatives to complex biomechanical simulations, potentially facilitating their integration into occupational risk assessment frameworks.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"197 ","pages":"Article 113190"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finger flexor and extensor muscles load sharing: Effect of the climbing grip technique","authors":"Xavier Hugues ,&nbsp;Franck Quaine ,&nbsp;Antoine Nordez ,&nbsp;Titouan Perrin ,&nbsp;Pierre Beaudoin ,&nbsp;Julien V. Brugniaux ,&nbsp;François Moutet ,&nbsp;Violaine Cahouet","doi":"10.1016/j.jbiomech.2026.113193","DOIUrl":"10.1016/j.jbiomech.2026.113193","url":null,"abstract":"<div><div>Rock climbing requires significant fingertip flexion force generated using two well identified classical gripping techniques: the crimp and slope grips. Although these grips are biomechanically relevant, few methods allow for precise evaluation of individual agonist and antagonist muscle contributions. This study aimed to use Shear Wave Elastography (SWE) to compare flexor digitorum profundus (FDP), flexor digitorum superficialis (FDS), and extensor digitorum communis (EDC) muscle contraction between crimp and slope grips during submaximal isometric flexion fingertip force exertion. Additionally, the repeatability of SWE measurements was assessed.</div><div>Forty-six experienced climbers performed isometric ramp contractions in both grip types. The shear modulus was quantified using SWE and synchronised with fingertip force data from a custom-built ergometer. Repeatability analysis showed moderate to excellent reliability (ICC: 0.62–0.83) despite notable intra-individual variability (SEM: 10–23 kPa), likely arising from probe positioning conditions. These findings support the reliability of SWE for assessing functional muscle mechanics, although caution is warranted in interpreting shear modulus differences. FDP displayed greater shear modulus in slope grip, while the FDS was stiffer in crimp grip, reflecting grip-dependent muscle recruitment. In slope grip, early and substantial force production by the FDP appears essential for stabilising the distal interphalangeal (DIP) joint and generating flexion force at the fingertip. In the crimp grip, the FDS contributes more significantly to force production, likely due to its advantageous moment arm at the proximal interphalangeal (PIP) joint. Finally, EDC shear modulus increased with fingertip force in both grips, indicating co-contraction. This effect was more pronounced in slope grip, likely reflecting a greater stabilisation demand when passive joint constraints are reduced.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"198 ","pages":"Article 113193"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pharmacological modulation of aortic hemodynamic condition by extreme heat","authors":"Jiyang Zhang ,&nbsp;Lingjun Liu ,&nbsp;Wentao Jiang ,&nbsp;Ming Zhang ,&nbsp;Taoping Bai ,&nbsp;Yu Chen ,&nbsp;Fei Gao ,&nbsp;Zhongyou Li","doi":"10.1016/j.jbiomech.2026.113175","DOIUrl":"10.1016/j.jbiomech.2026.113175","url":null,"abstract":"<div><div>Extreme heat exposure is a promising non-pharmacological strategy for cardiovascular health, yet its underlying hemodynamic mechanisms remain poorly understood. Here, computational fluid dynamics (CFD) was used to assess heat-induced changes in aortic blood flow. Three-dimensional aortic geometries were reconstructed from computed tomography scans of six healthy adults (mean age: 50.8 ± 12.8  years). Inlet conditions were adjusted to simulate thermal stress (80–100 °C) based on reported increases in cardiac output (67%) and heart rate (33%), whereas outlet boundaries were modeled using Windkessel elements with parameters tuned for flow redistribution. The effects of vascular deformation were accounted for using a fluid–structure interaction approach. Key hemodynamic metrics, including time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT), and endothelial cell activation potential (ECAP), were quantified before and after heat exposure. In parallel, 12 rats were randomly assigned to a heat-exposed group (n = 6; 41 °C, 20  min) or a control group (n = 6; 24 °C, 20  min), after which the abdominal aorta was harvested for immunofluorescence analysis of eNOS expression. Wall shear stress increased by at least 89.9% throughout the aorta and across the cardiac cycle, with the greatest increase observed at the aortic arch. TAWSS exhibited an inverse “S”-shaped spatial distribution, with regions of higher baseline shear showing greater amplification. In contrast, OSI and RRT decreased during heat exposure. On average, TAWSS rose by 108.5%, whereas OSI and RRT fell by 22.5% and 56.5%, respectively. eNOS expression in rat aortas was significantly higher in the heat-exposed group than in the control group (P &lt; 0.05). Additionally, ECAP decreased by 57.1% during heat exposure. These results demonstrate that heat exposure significantly enhances aortic hemodynamics and may serve as a non-pharmacological strategy to improve arterial function, offering a potential alternative for individuals unable to exercise.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"197 ","pages":"Article 113175"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hip adduction moment as a proxy for joint loading: a comparison between walking and running","authors":"Ransi S.S. Subasinghe Arachchige ,&nbsp;Torrance Mclean ,&nbsp;Roy T.H. Cheung","doi":"10.1016/j.jbiomech.2026.113200","DOIUrl":"10.1016/j.jbiomech.2026.113200","url":null,"abstract":"<div><div>Hip adduction moment (HAM) is commonly used as a surrogate for hip joint loading; however, its validity across different gait tasks and modifications remains unclear. Understanding how gait modification influences this relationship is essential for developing effective load-management strategies for individuals with or at risk of hip osteoarthritis. This study examined the relationship between HAM and hip joint reaction force (HJRF) during walking and running under natural and foot progression modification conditions in healthy adults. Musculoskeletal modelling in OpenSim was used to estimate HJRF, and inverse dynamics were applied to calculate HAM. Spearman’s correlation coefficients were used to assess the relationship between HAM and HJRF across gait conditions. Paired t-tests and linear mixed models, accounting for speed where applicable, assessed differences between natural and modified gait.</div><div>During walking, early stance HAM was strongly correlated with HJRF in both natural (ρ = 0.923, p &lt; 0.001) and toe-in conditions (ρ = 0.851, p &lt; 0.001). Toe-in walking significantly reduced HAM (p = 0.017) and HJRF (p = 0.037) compared to natural walking. During running, peak HAM had lower but significant correlation with HJRF in the natural condition (ρ = 0.703, p &lt; 0.001), but no significant association was observed during toe-out running (p = 0.065). Toe-out running significantly decreased HAM (p = 0.006) while HJRF remained unchanged (p = 0.941). Gait modification influences the coupling between HAM and HJRF, particularly during dynamic tasks such as running. While HAM is a valid indicator of hip loading during walking, it becomes less representative under altered dynamic conditions. These findings highlight the limitations of using single-plane moments as a surrogate for joint loading.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"198 ","pages":"Article 113200"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilayered soft material characterization using surface wave elastography and laser Doppler vibrometry","authors":"Nasser Ghaderi ,&nbsp;Ali Golmohammadi ,&nbsp;Simon Verspeek ,&nbsp;Joris Dirckx ,&nbsp;Steve Vanlanduit","doi":"10.1016/j.jbiomech.2026.113203","DOIUrl":"10.1016/j.jbiomech.2026.113203","url":null,"abstract":"<div><div>To characterize mechanical properties in layered media, we present a broadband surface-wave elastography approach for estimating shear wave speeds in a three-layer soft sample using a scanning laser Doppler vibrometer (LDV). Surface waves were generated using a piezoelectric transducer and measured on a layered phantom mimicking skin, including an embedded stiff inclusion representing a skin abnormality. By extending the axial displacement profile of Rayleigh waves in a single-layer half-space to a multilayered medium, we enabled forward modeling and inversion to estimate the shear wave speeds of each layer. The inversion assumed elastic layers, with estimated speeds compared to reference values from single-layer wave elastography. While overall layer characterization showed higher error, mainly due to viscoelastic effects not captured in the model, the inclusion was accurately identified. The embedded inclusion, with a shear wave speed about 1.7 times that of surrounding material, was estimated with only 1.5% error, and the surrounding layer with approximately 10% error. In addition, in vivo measurements were performed on the human forearm skin, demonstrating the feasibility of the proposed method under realistic physiological conditions and strengthening the clinical relevance of the study. The approach is adaptable to alternative excitation and measurement methods and offers high sensitivity, as demonstrated by LDV’s ability to detect low-amplitude displacements. This methodology is suitable for skin tissues and holds promise for diagnosing abnormalities and monitoring treatment response.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"198 ","pages":"Article 113203"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalization of military load carriage simulations affects muscle and joint contact forces","authors":"Anna C. Corman ,&nbsp;Jordan T. Sturdy ,&nbsp;Hedaya N. Rizeq ,&nbsp;Carlie J. Daquino ,&nbsp;Tyler T. Whittier ,&nbsp;Amy Silder ,&nbsp;Pinata H. Sessoms ,&nbsp;Anne K. Silverman","doi":"10.1016/j.jbiomech.2026.113211","DOIUrl":"10.1016/j.jbiomech.2026.113211","url":null,"abstract":"<div><div>Military overuse injuries are associated with greater internal loads during load carriage and cause decreased readiness and increased costs. Low physical fitness, including low muscle strength, is a modifiable injury risk factor, making it an important focus for injury prevention. Evaluating potential injury mechanisms from biomechanical modeling and simulation may be useful, particularly for individuals who have unique muscle strengths and body segment mass distributions. However, modeled muscle strength from average adults is likely underestimated for trained, active-duty military personnel, which may influence internal load calculations. Thus, we evaluated the effects of muscle strength and segment mass distribution personalization on joint contact impulses and peak forces, and muscle force impulses from musculoskeletal simulations. Full-body kinematics, ground reaction forces, and electromyography were collected from 16 active-duty participants under two walking conditions: 1) no-pack and 2) pack (posteriorly added load, total 46 kg). These data drove and validated simulations of models with different types of personalization. Modeled segment masses were scaled using measured regional masses from dual-energy x-ray absorptiometry. Modeled muscle strengths were scaled from eight maximum voluntary isometric contractions measured using an instrumented dynamometer including the lumbar, hip, knee, and ankle. Personalized mass-distribution scaling had 6% greater lumbar joint contact impulses in walking compared to not personalized (p = .006). Personalized muscle strength scaling had greater joint contact impulses at the lumbar (42%), hip (25%), and knee (8%) (p &lt; .001), and smaller impulses at the ankle (−4%) (p = .048) compared to not personalized. Results were similar for peak joint contact forces. Model personalization is beneficial to quantify internal loading and evaluate training interventions.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"198 ","pages":"Article 113211"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146226976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue ingrowth in a porous acetabular component: Influence of mechanobioregulatory stimuli","authors":"Ceby Mullakkara Saviour ,&nbsp;Ayushi Prasad ,&nbsp;Sanjay Gupta","doi":"10.1016/j.jbiomech.2026.113202","DOIUrl":"10.1016/j.jbiomech.2026.113202","url":null,"abstract":"<div><div>Porous acetabular component has been often used in total hip arthroplasty since they allow biological anchorage with the host bone, facilitating long term implant stability. However, the extent of the tissue ingrowth around porous metal-backing has been scarcely investigated. Using a novel multiscale mechanobioregulatory framework, the study investigated the spatio-temporal evolution of tissue ingrowth in an optimally designed functionally graded porous acetabular component. Finite element microscale models corresponding to different acetabular regions were developed, along with the macroscale model of the implanted hemipelvis. The variable implant-bone relative displacements and the host bone material properties in ten interfacial regions, were mapped from the macroscale model to microscale model. Bone formation of 0.55 – 86.65% was predicted across the microscale models, resulting in an average elastic modulus ranging between 32.52 and 1977.70 MPa. The overall average percentage of peri-acetabular bone ingrowth was ∼ 27%, with high bone ingrowth of ∼ 40 – 87% around the acetabular dome. Although the biological stimulus was favourable in vicinity of the bone layer, the mechanical stimuli in the tissue elements adjacent to the implant was found to be more favourable for bone formation as compared to the elements adjacent to bone. Predicted amount of peri-prosthetic tissue ingrowth was observed to be dependent on the biological factors, in addition to the mechanical environment. Occurrence of contact osteogenesis indicated the predominant influence of mechanical stimuli over biological factors in the predictions of bone ingrowth around functionally graded porous acetabular component.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"198 ","pages":"Article 113202"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}