Personalized musculoskeletal model based multi-muscle force analysis for amputees with transtibial prostheses

IF 2.4 3区医学 Q3 BIOPHYSICS

Journal of biomechanics Pub Date : 2025-08-30 DOI:10.1016/j.jbiomech.2025.112913

Yuwen Lu , Yan Huang , Wei Jin , Qining Wang

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引用次数: 0

Abstract

Understanding the biomechanical effects of transtibial prostheses is essential for their optimization and for improving amputee mobility. This study investigated how different prostheses impact intra-limb muscle coordination and inter-limb muscle force symmetry using personalized musculoskeletal models based on the sDIMS platform. Five transtibial amputees participated in gait trials with passive prostheses and active prostheses under varying damping conditions. The results were compared to those of five able-bodied controls. Through multi-muscle force analysis, we quantified muscle force magnitudes, identified coordination patterns, and evaluated inter-limb symmetry of multiple lower limb muscles using correlation coefficients, cyclograms, and symmetry indices. The results revealed distinct compensatory strategies in the intact limb based on group-level analysis. Furthermore, personalized evaluation based on multi-muscle force analysis enabled effective assessment of different prosthesis configurations in a subject-specific manner. These findings suggest that the proposed framework can improve prosthetic parameter selection and support the development of personalized control strategies, offering practical guidance for transtibial prosthesis optimization.

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基于个性化肌肉骨骼模型的假肢截肢者多肌肉力分析

了解跨胫义肢的生物力学效应对其优化和改善截肢者的活动能力至关重要。本研究利用基于sDIMS平台的个性化肌肉骨骼模型，研究了不同假肢对肢体内肌肉协调和肢体间肌肉力量对称的影响。五名经胫截肢者在不同的阻尼条件下参与被动假肢和主动假肢的步态试验。研究人员将结果与5名健全的对照组进行了比较。通过多肌肉力量分析，我们量化了肌肉力量的大小，确定了协调模式，并使用相关系数、环图和对称指数评估了多个下肢肌肉的肢间对称性。基于群体水平分析，结果揭示了完整肢体中不同的代偿策略。此外，基于多肌肉力分析的个性化评估能够以特定受试者的方式有效评估不同的假体配置。这些结果表明，所提出的框架可以改善假体参数的选择，支持个性化控制策略的发展，为胫骨假体优化提供实用指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of biomechanics 生物-工程：生物医学

CiteScore

5.10

自引率

4.20%

发文量

345

审稿时长

1 months

期刊介绍： The Journal of Biomechanics publishes reports of original and substantial findings using the principles of mechanics to explore biological problems. Analytical, as well as experimental papers may be submitted, and the journal accepts original articles, surveys and perspective articles (usually by Editorial invitation only), book reviews and letters to the Editor. The criteria for acceptance of manuscripts include excellence, novelty, significance, clarity, conciseness and interest to the readership. Papers published in the journal may cover a wide range of topics in biomechanics, including, but not limited to: -Fundamental Topics - Biomechanics of the musculoskeletal, cardiovascular, and respiratory systems, mechanics of hard and soft tissues, biofluid mechanics, mechanics of prostheses and implant-tissue interfaces, mechanics of cells. -Cardiovascular and Respiratory Biomechanics - Mechanics of blood-flow, air-flow, mechanics of the soft tissues, flow-tissue or flow-prosthesis interactions. -Cell Biomechanics - Biomechanic analyses of cells, membranes and sub-cellular structures; the relationship of the mechanical environment to cell and tissue response. -Dental Biomechanics - Design and analysis of dental tissues and prostheses, mechanics of chewing. -Functional Tissue Engineering - The role of biomechanical factors in engineered tissue replacements and regenerative medicine. -Injury Biomechanics - Mechanics of impact and trauma, dynamics of man-machine interaction. -Molecular Biomechanics - Mechanical analyses of biomolecules. -Orthopedic Biomechanics - Mechanics of fracture and fracture fixation, mechanics of implants and implant fixation, mechanics of bones and joints, wear of natural and artificial joints. -Rehabilitation Biomechanics - Analyses of gait, mechanics of prosthetics and orthotics. -Sports Biomechanics - Mechanical analyses of sports performance.