{"title":"Prediction of sperm motion behavior in microfluidic channel using sperm swimming model","authors":"Toru Hyakutake , Daisuke Higashiyama , Tomoka Tsuchiya","doi":"10.1016/j.jbiomech.2024.112336","DOIUrl":"10.1016/j.jbiomech.2024.112336","url":null,"abstract":"<div><div>Several investigations have recently been conducted using microfluidic channels to sort highly motile sperm and thereby increase the probability of fertilization. To further enhance the efficiency of sperm sorting, predicting sperm movement in microfluidic channels through simulation techniques could be beneficial. In this study, we constructed a sperm swimming model based on the concept of an agent-based model. This model allows analysis at the same spatio–temporal scale similar to microfluidic channels. Sperm movement was simplistically modeled as a random walk, utilizing the distribution of sperm velocity and deflection angle obtained from experimental data. We have developed a thigmotaxis model to describe the phenomenon where sperm near the wall exhibit a reduced tendency to move away from it. Additionally, we created a rheotaxis model, in which sperm reorient in the direction opposite to the flow depending on the shear rate. Using these models, we investigated sperm behaviors within a microchannel featuring a tapered area. The results reveal that sperm accumulate within the tapered area, leading to a significant increase in sperm concentration for specific flow velocity ranges in the microchannel. This model provides valuable information for predicting the effects of sperm sorting in various microfluidic channels.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"176 ","pages":"Article 112336"},"PeriodicalIF":2.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jianqiao Guo , Hao Tang , Xinxin Li , Yanbing Wang , Shaoyi Guo , Qiang Tian , Yixin Zhou
{"title":"Kinematic–kinetic compliant acetabular cup positioning based on preoperative motion tracking and musculoskeletal modeling for total hip arthroplasty","authors":"Jianqiao Guo , Hao Tang , Xinxin Li , Yanbing Wang , Shaoyi Guo , Qiang Tian , Yixin Zhou","doi":"10.1016/j.jbiomech.2024.112332","DOIUrl":"10.1016/j.jbiomech.2024.112332","url":null,"abstract":"<div><div>The invention of the surgical robot enabled accurate component implantation during total hip arthroplasty (THA). However, a preoperative surgical planning methodology is still lacking to determine the acetabular cup alignment considering the patient-specific hip functions during daily activities such as walking. To simultaneously avoid implant edgeloading and impingement, this study established a kinematic–kinetic compliant (KKC) acetabular cup positioning method based on preoperative gait kinematics measurement and musculoskeletal modeling. Computed tomography images around the hip joint and their biomechanical data during gait, including motion tracking and foot–ground reaction forces, were collected. Using the reconstructed pelvic and femur geometries, the patient-specific hip muscle insertions were located in the lower limb musculoskeletal model via point cloud registration. The designed cup orientation has to be within the patient-specific safe zone to prevent implant impingement, and the optimized value selected based on the time-dependent hip joint reaction force to minimize the risk of edgeloading. As a validation of the proposed musculoskeletal model, the predicted lower limb muscle activations for seven patients were correlated with their surface electromyographic measurements, and the computed hip contact force was also in quantitative agreement with data from the literature. However, the designed cup orientations were not always within the well-known Lewinnek safe zone, highlighting the importance of KKC surgical planning based on patient-specific biomechanical evaluations.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"176 ","pages":"Article 112332"},"PeriodicalIF":2.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josephine M. Kalshoven , Rohit Badida , Amy M. Morton , Janine Molino , Joseph J. Crisco
{"title":"Do osteophytes alter thumb carpometacarpal Biomechanics? a preliminary in vitro study","authors":"Josephine M. Kalshoven , Rohit Badida , Amy M. Morton , Janine Molino , Joseph J. Crisco","doi":"10.1016/j.jbiomech.2024.112333","DOIUrl":"10.1016/j.jbiomech.2024.112333","url":null,"abstract":"<div><div>Osteoarthritis (OA) of the thumb carpometacarpal (CMC) joint is prevalent and debilitating, marked by substantial loss of range of motion (ROM) and overall function. CMC OA is associated with osteophyte growth, but the impact of this growth on CMC ROM has not been systematically characterized. Our goal was to determine whether osteophytes decrease CMC ROM and, if so, whether these decreases are direction-dependent. A robotic musculoskeletal simulation system was used to manipulate 18 CMC specimens with a range of joint health following three test protocols: (1) Rotational ROM in flexion, extension, abduction, adduction, and 20 combined directions, (2) Internal/External Rotation (IR/ER), and (3) Translational ROM in volar, dorsal, radial, ulnar, and 4 combined directions. Osteophyte volume (OV) was computed in total and by volar, dorsal, radial, and ulnar quadrants, and correlations with ROM were computed by direction and in total. We found that an increase in overall trapezial OV was associated with a reduction in overall rotational ROM and IR/ER, but not with translational ROM. We found decreased extension was associated with increased ulnar, volar, and radial OV, and decreased abduction was associated with increased volar OV. Decreased internal rotation was associated with increased ulnar, volar, and radial OV. The proposed method and findings of this pilot study will lay the groundwork for a larger investigation into the relationship between pathological structure and function in the CMC joint.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"176 ","pages":"Article 112333"},"PeriodicalIF":2.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Repeatability of two methods for estimating scapular kinematics during dynamic functional tasks","authors":"Angelica E. Lang","doi":"10.1016/j.jbiomech.2024.112334","DOIUrl":"10.1016/j.jbiomech.2024.112334","url":null,"abstract":"<div><p>Best practices for scapular motion tracking are still being determined. The repeatability of different scapular kinematic procedures needs to be evaluated. The purpose of this study was to assess the test-retest reliability of two scapular kinematic procedures: double calibration with AMC (D-AMC) and individualized linear modelling (LM). Ten healthy participants had their upper body movement tracked with optical motion capture in two identical sessions. Five scapular calibration poses were performed, and seven dynamic functional tasks were tested. Scapular angles were calculated from both procedures (D-AMC vs LM). The D-AMC approach uses two poses (neutral and maximum elevation) and tracks the scapula with a rigid cluster, while the LM approach predicts scapular positioning from humeral angles based on equations built from the calibration pose data. Angle waveforms and repeatability outcomes were compared. Internal and upward rotation angle waveforms were significantly different (p < 0.05) between kinematic procedures for some tasks, with maximum mean differences up to 17.3° and 23.2°, respectively. Overall, repeatability outcomes were similar between procedures, but the LM approach was slightly better for tilt and the D-AMC approach was notably improved for upward rotation in certain tasks. For example, minimal detectable changes during the Forward Transfer ranged from 6.9° to 11.9° for the D-AMC and 8.9° to 25.3° for the LM. Discrepancies between procedures may be a function of the calibration poses chosen. Additional calibration poses may improve the comparisons between procedures.</p></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"176 ","pages":"Article 112334"},"PeriodicalIF":2.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021929024004123/pdfft?md5=db359fa6f3f2d4ac7ce570c39baf45ce&pid=1-s2.0-S0021929024004123-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Oliviero , Antonino A. La Mattina , Giacomo Savelli , Marco Viceconti
{"title":"In Silico clinical trial to predict the efficacy of hip protectors for preventing hip fractures","authors":"Sara Oliviero , Antonino A. La Mattina , Giacomo Savelli , Marco Viceconti","doi":"10.1016/j.jbiomech.2024.112335","DOIUrl":"10.1016/j.jbiomech.2024.112335","url":null,"abstract":"<div><p>Osteoporosis is characterized by loss of bone mineral density and increased fracture risk. Reduction of hip fracture incidence is of major clinical importance. Hip protectors aim to attenuate the impact force transmitted to the femur upon falling, however different conclusions on their efficacy have been reported; some authors suggest this may be due to differences in compliance. The aim of this study was to apply an <em>In Silico</em> trial methodology to predict the effectiveness of hip protectors and its dependence on compliance.</p><p>A cohort of 1044 virtual patients (Finite Element models of proximal femur) were generated. A Markov chain process was implemented to predict fracture incidence with and without hip protectors, by simulating different levels of compliance. At each simulated follow-up year, a Poisson distribution was randomly sampled to determine the number of falls sustained by each patient. Impact direction and force were stochastically sampled from a range of possible scenarios. The effect of wearing a hip protector was simulated by applying attenuation coefficients to the impact force (12.9 %, 19 % and 33.8 %, as reported for available devices). A patient was considered fractured when impact force exceeded the femur strength.</p><p>Without hip protector, virtual patients experienced 66 ± 5 fractures in 10 years. Wearing the three devices, fracture incidence was reduced to 43 ± 4, 35 ± 4 and 17 ± 2 respectively, at full compliance. As expected, effectiveness was dependent on compliance.</p><p>This <em>In Silico</em> trial technology can be applied in the future to test multiple interventions, optimise intervention strategies, improve clinical trial design and drug development.</p></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"176 ","pages":"Article 112335"},"PeriodicalIF":2.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021929024004135/pdfft?md5=3a4fe634f56146bf7ef130db83fd5829&pid=1-s2.0-S0021929024004135-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simulating vortex generation to investigate the propulsive and braking mechanisms of breaststroke kick using computational fluid dynamics on a breaststroke swimmer","authors":"Takahiro Tanaka , Taisei Hayashi , Tadao Isaka","doi":"10.1016/j.jbiomech.2024.112329","DOIUrl":"10.1016/j.jbiomech.2024.112329","url":null,"abstract":"<div><p>Swimmers primarily increase their forward velocity through lower limb motion in breaststroke, making the breaststroke kick crucial for optimizing race times. Recent studies have highlighted the generation of vortices around the swimmer’s entire body to propel forward during swimming. However, the investigation of vortex generation during breaststroke kicks remains unexplored. This study aimed to reveal the propulsive and braking mechanisms of breaststroke kicks by simulating vortex generation using computational fluid dynamics (CFD). Kinematic data during the breaststroke kick and a three-dimensional digital model were collected to conduct CFD for a male breaststroke swimmer. Vortex generation was determined during one breaststroke kick from the CFD results. Vortices, which potentially induce a decrease in forward velocity, were generated by the swimmer’s lower legs and feet during the recovery phase. The swimmer generated vortices on the dorsal side of the feet and the posterior and lateral sides of the lower legs to increase the forward velocity during the out-sweep phase. The swimmer generated vortices on the lateral sides of the thighs and lower legs and the dorsal and lateral sides of the feet during the in-sweep phase to maintain forward velocity. Moreover, vortices generated from the out-sweep to the in-sweep merged and were shed backward relative to the swimming direction after the in-sweep phase. This study is the first to reveal the propulsive and braking mechanisms of breaststroke kicks by analyzing the vortex generation.</p></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"176 ","pages":"Article 112329"},"PeriodicalIF":2.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S002192902400407X/pdfft?md5=0906165a66ed8300e79db0c4f3d8af4b&pid=1-s2.0-S002192902400407X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mason L. Stolycia , David E. Lunn , Richard A. Wilkins , Cleveland T. Barnett , Josh Walker
{"title":"Walking in a controlled ankle motion (CAM) boot: In-boot measurement of joint kinematics and kinetics","authors":"Mason L. Stolycia , David E. Lunn , Richard A. Wilkins , Cleveland T. Barnett , Josh Walker","doi":"10.1016/j.jbiomech.2024.112327","DOIUrl":"10.1016/j.jbiomech.2024.112327","url":null,"abstract":"<div><p>Research investigating ankle function during walking in a controlled ankle motion (CAM) boot has either placed markers on the outside of the boot or made major alterations to the structure of the CAM boot to uncover key landmarks. The aim of this study was to quantify joint kinematics and kinetics using “in-boot” skin markers whilst making only minimal structural alterations. Seventeen healthy participants walked at their preferred walking speed in two conditions: (1) in standard athletic trainers (ASICS patriot 8, ASICS Oceania Pty Ltd, USA), and (2) using a hard-cased CAM boot (Rebound® Air Walker, Össur, Iceland) fitted on the right foot. Kinematic measurements revealed that CAM boots restrict sagittal plane ankle range of motion to less than 5°, and to ∼3° in the frontal plane, which is a reduction of 85% and 73% compared to standard footwear, respectively (<em>p</em> < 0.001). This ankle restriction resulted in a reduction of ankle joint total limb work contribution from 38 ± 5% in normal footwear to 13 ± 4% in the CAM boot (<em>p</em> < 0.001). This study suggests that CAM boots do restrict the ankle joint’s ability to effectively perform work during walking, which leads to compensatory mechanisms at the ipsilateral and contralateral hip and knee joints. Our findings align with previous research that employed “on-boot” kinematic measurements, so we conclude that in-boot approaches do not offer any benefit to the researcher and instead, on-boot measurements are suitable.</p></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"176 ","pages":"Article 112327"},"PeriodicalIF":2.4,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021929024004056/pdfft?md5=586cc230f36d8cc9b4ab3e58200ddb76&pid=1-s2.0-S0021929024004056-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sonali M. Bauer , Klaus Vogt , Klaus-D. Wernecke , Gerd Rasp , Karen Parker Davidson , Sebastian Roesch
{"title":"Quantitative measurement of the flow depending nasal valve function by elastography with electro-optical distance sensors. A pilot study","authors":"Sonali M. Bauer , Klaus Vogt , Klaus-D. Wernecke , Gerd Rasp , Karen Parker Davidson , Sebastian Roesch","doi":"10.1016/j.jbiomech.2024.112326","DOIUrl":"10.1016/j.jbiomech.2024.112326","url":null,"abstract":"<div><p>Nasal valve function depends on the intensity of the inspiratory nasal airflow, the geometry of the nasal entrance and the mechanical properties of the lateral nasal wall. It is desirable to obtain objective information on the relation between flow and valve movement. In this study, the deflection of the lateral nasal wall and the inspiratory flow were measured on 30 healthy volunteers, aged 18 to 82 without a history of severe trauma or nasal surgery. Electro-optical distance sensors were housed under a full-face protective mask attached to an analogue inspiratory flowmeter. The mean values for normal breathing were assessed at 675 [cm<sup>3</sup>/s] for the bilateral flow and −0.57 mm for the total movement. With forced breathing, the mean values for the flow of both nostrils were found to be 1434 cm<sup>3</sup>/s and for the total movement −1.21 mm. Statistically significant differences between normal and forced breathing were found in all participants and in both sexes, but no significant correlation by age. Electro-optical distance measurement, representing a novel technical way for the ‘elastography’ of the nasal valve should be added to advanced 4-phase-rhinomanometers.</p></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"176 ","pages":"Article 112326"},"PeriodicalIF":2.4,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andréa El-Khoury , Lawrence Leroux , Julien Dupuis Desroches , Giuseppe Di Labbio , Lyes Kadem
{"title":"Design and validation of an In Vitro test bench for the investigation of cardiopulmonary resuscitation procedure","authors":"Andréa El-Khoury , Lawrence Leroux , Julien Dupuis Desroches , Giuseppe Di Labbio , Lyes Kadem","doi":"10.1016/j.jbiomech.2024.112324","DOIUrl":"10.1016/j.jbiomech.2024.112324","url":null,"abstract":"<div><p>Despite recent clinical and technological advancements, the cardiac arrest survival rate remains as low as 10%. To enhance patient outcomes, it is crucial to deepen the understanding of cardiopulmonary resuscitation (CPR) at a fundamental level. Currently, there is a lack of knowledge on the physiological effects of CPR, in particular on the hemodynamics in the heart and the great vessels. The design and validation of a dedicated in vitro heart simulator, capable of replicating the physiological response to CPR, holds the potential to provide valuable insights into the fluid dynamics in the heart during CPR but also to be used as a platform for the development and testing of mechanical CPR machines. The main objective of this study is to design and validate the first in vitro heart simulator that can replicate the physiological response during CPR. For that, a custom-made heart simulator is designed consisting of an elastic model of the complete heart and a controllable linear actuator. The heart model is positioned in an anatomical position, and the linear actuator compresses the model at specific rates and depths. Flow and pressure waveforms are recorded on the newly developed simulator at 60 contractions per minute and results are validated against reported in vivo data in the literature. Finally, the system’s capabilities are evaluated by considering several combinations of compression rates and depths.</p></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"176 ","pages":"Article 112324"},"PeriodicalIF":2.4,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julie A. Hides , M. Dilani Mendis , Felix Leung , Brittany Grantham , Brooke Coombes
{"title":"Exploring the relationship between trunk muscles and lower limb injuries in Australian badminton players","authors":"Julie A. Hides , M. Dilani Mendis , Felix Leung , Brittany Grantham , Brooke Coombes","doi":"10.1016/j.jbiomech.2024.112325","DOIUrl":"10.1016/j.jbiomech.2024.112325","url":null,"abstract":"<div><p>Due to its dynamic nature, lower limb injuries are common in badminton. Overuse injuries of the knee, including tendon related conditions, are the most common. During jumping and landing, force transference and dissipation through the trunk is required, with the trunk muscles playing a vital role. However, the relationship between knee pain and the ability to voluntarily contract the trunk muscles has not yet been explored in badminton players. A cross-sectional study of Australian badminton players was therefore conducted. Players performed a single leg decline squat to identify those with knee pain. Ultrasound imaging was used to image and measure the size of the multifidus and quadratus lumborum, and the ability to contract the abdominal and multifidus muscles. Voluntary contraction of the trunk muscles was conducted with the subjects lying down. Independent samples T-Tests were performed to test for between group differences. Badminton players with knee pain had larger quadratus lumborum muscles and demonstrated a greater change in muscle thickness from the rested to contracted state. While we cannot comment on causation or direction, over co-contraction of trunk muscles has been shown in other studies to be associated with increased ground reaction forces on landing. Motor control training has been successfully used in other conditions to modify trunk muscle recruitment patterns and may therefore potentially represent a useful approach for badminton players.</p></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"176 ","pages":"Article 112325"},"PeriodicalIF":2.4,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021929024004032/pdfft?md5=8d1aa0cb7175f251075ed22a759fc63b&pid=1-s2.0-S0021929024004032-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}