Journal of biomechanics最新文献

{"title":"Hemodynamic simulation analysis of tandem carotid artery stenosis based on a patient-specific case","authors":"Junjie Cao ,&nbsp;Ziyi Tan ,&nbsp;Yao Tang ,&nbsp;Zhanao Liu ,&nbsp;Jian Huang ,&nbsp;Guijun Huo ,&nbsp;Zhichao Yao ,&nbsp;Yang Zhou ,&nbsp;Dayong Zhou","doi":"10.1016/j.jbiomech.2025.112907","DOIUrl":"10.1016/j.jbiomech.2025.112907","url":null,"abstract":"<div><div>Tandem carotid artery stenosis (TCAS) presents significant hemodynamic challenges, necessitating a multidisciplinary approach to treatment. This study integrates imaging, pathology, and computational fluid dynamics (CFD) to analyze a patient-specific TCAS case. A three-dimensional (3D) model of the carotid bifurcation was reconstructed from computed tomography angiography (CTA) scans, and CFD simulations assessed hemodynamic parameters under different stenosis conditions. Preoperative imaging was cross-referenced with postoperative histology to identify regions of elevated time-averaged wall shear stress (TaWSS), indicative of plaque vulnerability, and areas of abrupt TaWSS reduction, which may signal potential rupture sites. Additionally, surgical intervention models revealed that internal carotid artery (ICA) stenosis had a more pronounced effect on blood flow and hemodynamics compared to common carotid artery (CCA) stenosis, emphasizing the complexity of tandem lesions. These findings suggest that integrating advanced imaging, pathology, and CFD could enhance personalized treatment strategies for TCAS, improving understanding of the associated hemodynamic risks.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"191 ","pages":"Article 112907"},"PeriodicalIF":2.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144828641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of shoulder kinematics between Theia 3D markerless motion capture and marker-based motion capture during full arm ranges of motion","authors":"Eleonora Croci ,&nbsp;Christoph Künzel ,&nbsp;Dominic Gehring ,&nbsp;Andreas Marc Müller ,&nbsp;Annegret Mündermann","doi":"10.1016/j.jbiomech.2025.112905","DOIUrl":"10.1016/j.jbiomech.2025.112905","url":null,"abstract":"<div><div>While markerless motion capture system has recently gained interest, little is known on the accuracy of Theia 3D for measuring shoulder kinematics. This study aimed to compare shoulder kinematics across the full range of arm motion between Theia 3D and a gold standard marker-based motion capture system. Shoulder kinematics of 20 healthy subjects were measured during three repetitions of bilateral full arm scaption, abduction, flexion, internal rotation, external rotation, and internal and external rotation at 90° abduction. Data were simultaneously collected with Theia 3D (v2024.1.24) markerless and marker-based motion capture. Markerless and marker-based angular trajectories had similar patterns, with larger differences towards the inflection point of the movements and with the markerless trajectories having mostly greater values than marker-based trajectories. Root mean square differences were smallest for abduction angles (&lt;6°) and largest for the external rotation angles (15.3°–22.3°). Coefficients of multiple correlations (CMCs) were mostly good to excellent (&gt;0.75), but CMC was moderate (0.65–0.75) for flexion angles during rotation at 90° and weak (&lt;0.65) for flexion angles during external rotation. For almost all tasks, the ranges of motion differed significantly between the two measurement systems in all three planes. However, mean differences in the coronal plane and in the sagittal plane were within the minimal clinically important differences. We found moderate to very strong correlations between the range of motion parameters of the two measurement methods. The assessment of shoulder kinematics with Theia 3D is promising but further improvements are needed for clinical routine application.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"191 ","pages":"Article 112905"},"PeriodicalIF":2.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle forces and powers during sprint cycling at optimal cadence","authors":"Matthew T.O. Worsey ,&nbsp;Claire B. Crossley ,&nbsp;Thomas Wackwitz ,&nbsp;Tyler Collings ,&nbsp;Matthew N. Bourne ,&nbsp;Claudio Pizzolato","doi":"10.1016/j.jbiomech.2025.112890","DOIUrl":"10.1016/j.jbiomech.2025.112890","url":null,"abstract":"<div><div>This study describes lower limb musculotendon unit (MTU) forces and powers during sprint cycling. Seven participants (2 female) performed maximal effort cycling at optimal cadence. Three-dimensional motion capture, pedal forces, and surface electromyography (EMG) data were input into participant-calibrated EMG-informed neuromusculoskeletal models to evaluate forces and powers produced by 18 lower-limb MTUs. In the pushing phase (10° − 170°, relative to the right crank at top dead centre), the hip adductor group generated the highest average force (1623.78 ± 980.62 N) and the vastus lateralis generated the highest average positive power (193.11 ± 153.07 W). In the pulling phase (170°-350°), the hip adductor group generated the highest average force (1140.48 ± 482.57 N) and average power (60.47 ± 68.87 W). In the transition phase (350°-10°), the vastus lateralis generated the highest average force (1432.26 ± 1169.40 N) and average power (76.98 ± 71.84 W). MTU power crank cycle-profiles were generated for each participant, highlighting differences in patterns of MTU power generation. Future work is needed to determine if targeted training based on cyclist-specific MTU force and power model outputs would lead to improved sprint cycling performance.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"191 ","pages":"Article 112890"},"PeriodicalIF":2.4,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An original approach to generate periodic Representative Volume Elements with anisotropic heterogeneous microstructure: application to skeletal muscle","authors":"Aude Loumeaud ,&nbsp;Philippe Pouletaut ,&nbsp;Sabine F. Bensamoun ,&nbsp;Daniel George ,&nbsp;Simon Chatelin","doi":"10.1016/j.jbiomech.2025.112897","DOIUrl":"10.1016/j.jbiomech.2025.112897","url":null,"abstract":"<div><div>Skeletal muscle is an organ whose hierarchical, multiscale structure greatly influences the overall mechanical response. Complementary to mechanical experiments, finite element modeling is increasingly used to study the influence of its constituents across different scales. To develop such a multiscale model, particular attention must be paid not only to the scale transition, but also to the definition of the structure and its mechanical behavior at different scales (macroscopic, microscopic, submicron). One of the most effective approaches is to define a Representative Volume Element (RVE) including smaller scale components and their respective mechanical behavior laws, likely to be altered through pathologies.</div><div>In this study, an original approach for periodic RVE generation dedicated to multiscale modeling of the skeletal muscle is proposed. From optical microscopy cross-section images of mouse skeletal muscle and single fiber experiments, the RVE integrates parameters related to fiber type distribution, geometric and mechanical characteristics. The key features of this geometry are spatial periodicity, rounded edges and inclusion of experimentally measured probabilistic distributions of the extracellular matrix (ECM), slow and fast muscle fibers. Smooth variation of the mechanical properties between the muscle fibers and the ECM are implemented to avoid unrealistic and purely numerical stress accumulation at these interfaces through the definition of transition layers between the different microcomponents. By the inclusion of custom geometrical and material features, this original model allows the multiscale and multicomponent analysis of different muscle phenotypes and can also be used for other heterogeneous anisotropic materials such as fiber reinforced composites.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"191 ","pages":"Article 112897"},"PeriodicalIF":2.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple, not single, recipient muscle tendon transfers produce well-directed thumb-tip forces in lateral pinch grasp: A simulation study with application to restoration of improved grasp after tetraplegia","authors":"Oliver Garcia,&nbsp;Joseph D. Towles","doi":"10.1016/j.jbiomech.2025.112882","DOIUrl":"10.1016/j.jbiomech.2025.112882","url":null,"abstract":"<div><div>Thumb tendon transfer surgical procedures in patients with cervical spinal injury engage the paralyzed flexor pollicis longus (FPL) muscle to enable lateral pinch grasp. However, functional outcomes are mixed, in part because the FPL cannot consistently produce force at the thumb-tip to promote a stable grasp. We used simulation to investigate whether a multiple recipient muscle tendon transfer, targeting sets of paralyzed muscles driven by a single donor muscle, could outperform a single recipient muscle tendon transfer with the FPL alone and restore lateral pinch. We formed 36 groups of 2 muscles, 84 groups of 3 muscles, and 126 groups of 4 muscles. We used nonlinear optimization and in-situ measurements of muscle endpoint forces in 3 lateral pinch postures. In each posture, we primarily compared the orientation of the endpoint force of each muscle group to that produced by the FPL alone. We found that 116 of the 246 muscle groups produced endpoint forces that were more closely aligned with the direction perpendicular to the thumb (palmar direction) than the FPL was for wide and narrow lateral pinch postures and a posture in between. When averaged across the three postures, muscle force ranged from 0.1 to 90.4 N, muscle group endpoint force magnitudes ranged from 2.5 to 14.9 N, and muscle group endpoint force directions ranged from 17° to 49° relative to the palmar direction. The muscle group endpoint force directional range represented a mean improvement of 8° to 40° over the FPL’s mean endpoint force direction across all three postures. Our findings highlight the possibility of using multiple recipient muscle tendon transfers to restore grasp following cervical spinal cord injury.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"191 ","pages":"Article 112882"},"PeriodicalIF":2.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing radiographic spinopelvic alignment parameters using motion capture","authors":"Nicola Büttiker ,&nbsp;David Koch ,&nbsp;Annegret Mündermann ,&nbsp;Stefan Schären ,&nbsp;Stephen J. Ferguson ,&nbsp;Cordula Netzer ,&nbsp;Corina Nüesch","doi":"10.1016/j.jbiomech.2025.112894","DOIUrl":"10.1016/j.jbiomech.2025.112894","url":null,"abstract":"<div><div>While radiographic imaging is the gold standard for assessing spinopelvic alignment, it may not fully reflect symptom severity in patients with lumbar spinal stenosis (LSS) as patients employ dynamic compensatory strategies. This study aimed to develop a method to align static spinopelvic alignment parameters derived from motion capture with radiographic definitions. 27 patients underwent EOS radiography and motion capture analysis in a standardized posture. Radiopaque and retroreflective markers were placed on the same anatomical landmarks before EOS radiography and motion capture analysis, respectively. Offset angles were calculated to align motion capture-derived with radiographic parameters. Postural agreement between the two modalities was assessed using Bland-Altman analysis of the vertical distances between the posterior and anterior superior iliac spine markers (ASIS-PSIS) and the horizontal distances between the C7 and sacrum markers (SACR-C7). The influence of postural variation between modalities on alignment parameters was estimated using trigonometric analysis. Radiographic parameters differed notably from motion-capture derived parameters, particularly sacral slope, with an average offset of 31.1° (range: –0.4°–46.4°). The mean vertical ASIS-PSIS distance was −3.3 mm (LoA (limits of agreement): [−21.4; 14.8] mm) and the mean horizontal SACR-C7 distance was +4.9 mm (LoA: [−16.3; 26.1] mm), corresponding to maximum angular deviations of 5.9° for sacral slope and 3.7° for spine inclination. In conclusion, the large offset ranges underscore the need for radiography and individual offset corrections to approximate spinopelvic alignment parameters using motion capture. However, the close replication of the EOS posture highlights this method’s potential for assessing spinopelvic alignment in dynamic conditions.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"191 ","pages":"Article 112894"},"PeriodicalIF":2.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional gait kinematics and muscle collagen remodeling in rats of different ages and diets subjected to high-intensity exercise","authors":"Diogo Rodrigues Jimenes ,&nbsp;Nilton Rodrigues Teixeira Júnior ,&nbsp;Sara Suelen Carvalho de Oliveira ,&nbsp;Paulo Cezar de Freitas Mathias ,&nbsp;Douglas Lopes Almeida ,&nbsp;Wilson Rinaldi ,&nbsp;Carmem Patrícia Barbosa ,&nbsp;Pedro Paulo Deprá","doi":"10.1016/j.jbiomech.2025.112887","DOIUrl":"10.1016/j.jbiomech.2025.112887","url":null,"abstract":"<div><div>Most studies on rodent gait biomechanics focus on pathological conditions, but recent research has begun to explore moderate training. Aging and obesity lead to morphological and functional changes in skeletal muscle, especially in ECM and collagen fibers. Given the growing use of animal models, understanding how morphological and functional changes in skeletal muscle impact the three-dimensional angular kinematics of rat hindlimb gait in relation to the extracellular matrix (ECM) is essential. For this purpose, this study aimed to evaluate the three-dimensional angular kinematics of the knee and ankle during gait in rats of different ages, subjected to a high-fat diet (HFD) and HIIT, linking these aspects to muscle ECM characteristics. Male Wistar rats, aged seven, nine, 12, and 18 months, were divided into 16 groups (n = 7): T-SD and S-SD (trained and sedentary on standard diet), S-HFD and T-HFD (sedentary and trained on HFD). Trained rats underwent an 8-week HIIT protocol, 3x a week. Gait cycles were recorded, and ECM area and types I and III collagen in the soleus and EDL muscles were measured. HIIT reduced the maximum knee peak in T-SD groups (p = 0.0002), while HFD decreased this in S-HFD groups (p = 0.0012). HIIT also lowered the ankle peak in T-SD and T-HFD groups (p &lt; 0.0001). Muscle ECM remodeling and type I collagen were related to age (p &lt; 0.0001), while HIIT influenced type III collagen remodeling (p &lt; 0.0001). These findings advance understanding of motor behavior and ECM remodeling in obese and aged rodents, guiding age standardization in exercise studies.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"191 ","pages":"Article 112887"},"PeriodicalIF":2.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144828642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical mechanisms underlying propulsive force generation in wheelchair racing athletes","authors":"Mikito Hikosaka,&nbsp;Nadaka Hakariya,&nbsp;Noritaka Kawashima","doi":"10.1016/j.jbiomech.2025.112889","DOIUrl":"10.1016/j.jbiomech.2025.112889","url":null,"abstract":"<div><div>Wheelchair racing is one of the major competitive parasports for athletes with disabilities. Intensive training is necessary to acquire a unique wheelchair propulsive strategy that can be regarded as maximizing the residual function for athletes. We sought to elucidate the mechanisms underlying the unique modality of wheelchair racing performance based on a comprehensive biomechanical analysis. We collected data consisting of whole-body kinematics, electromyography of upper-limb and trunk muscles, and wheel torque during wheelchair propulsion from 20 athletes with different classifications and competition levels (13 males, seven females, aged 13–64 years). A classification-based comparison revealed that the peak torque angle of the T54 athletes (130 ± 18°) was deeper than that of the T52 athletes (106 ± 26°, p = 0.020) and the T53 athletes (87 ± 9°, p = 0.008). Regarding the competition levels, the elite athletes demonstrated larger torque generation at deeper handrim positions (124°–210°, t*&gt;3.207). These results suggest that torque generation at the deeper handrim position is a key factor in optimizing wheelchair propulsion with relevance to both residual function and acquired skill. In order to identify mechanisms underlying wheelchair racing performance, the kinematic-muscular synergy analysis based on muscle activation and joint kinematics was conducted. Detected synergies could be reasonably interpreted as the four distinct wheelchair propulsion phases: Contact, Push, Release, and Recovery. These functional components and their interaction with muscle recruitment and joint movement patterns reflect a common strategy of wheelchair propulsion across different classifications and competition levels. The present results contribute to updating our understanding of the biomechanical mechanisms underlying wheelchair racing performance.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"191 ","pages":"Article 112889"},"PeriodicalIF":2.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting 3D ground reaction forces across various movement tasks: a convolutional neural network study comparing different inertial measurement unit configurations","authors":"Batın Yılmazgün ,&nbsp;Jonas Weber ,&nbsp;Thorsten Stein ,&nbsp;Stefan Sell ,&nbsp;Bernd J. Stetter","doi":"10.1016/j.jbiomech.2025.112888","DOIUrl":"10.1016/j.jbiomech.2025.112888","url":null,"abstract":"<div><div>Ground reaction forces (GRFs) are crucial for understanding movement biomechanics and for assessing the load on the musculoskeletal system. While inertial measurement units (IMUs) are increasingly used for gait analysis in natural environments, they cannot directly capture GRFs. Machine learning can be applied to predict 3D-GRFs based on IMU data. However, previous studies mainly focused on vertical GRF (vGRF) and isolated movement tasks. This study aimed to systematically evaluate the prediction accuracy of convolutional neural networks (CNNs) for 3D-GRFs using IMUs from single and multiple sensor configurations across various movement tasks. 20 healthy participants performed six movement tasks including walking, stair ascent, stair descent, running, a running step turn and a running spin turn at self-selected speeds. CNNs were trained to predict 3D-GRFs on IMU time series data for different configurations (lower body [7 IMUs], single leg [4 IMUs], femur-tibia [2 IMUs], tibia [1 IMU] and pelvis [1 IMU]). Prediction accuracies were assessed based on leave-one-subject-out cross validations using Pearson correlation (r) and relative root mean squared error (relRMSE). Across all tasks, CNNs predicted vGRF most accurately (r = 0.98, relRMSE ≤ 7.44 %), followed by anterior-posterior GRF (r ≥ 0.92, relRMSE ≤ 14.24 %), with medial–lateral GRF being the least accurate (r ≥ 0.74, relRMSE ≤ 29.46 %). CNNs predicted vGRF consistently across tasks, with similar accuracy for multi IMU (average r = 0.98, average relRMSE: 6.06 %) and single IMU configurations (average r = 0.98, average relRMSE: 6.88 %), supporting single IMU configurations for vGRF in practical applications. During cutting maneuvers, the lower body configuration reduces the relRMSE for mlGRF (5.23–12.46 %) and apGRF (1.53–3.16 %) compared to single IMU configurations. However, for mlGRF and apGRF during cutting tasks, lower body configuration improve accuracy, highlighting a trade-off between simplicity and performance.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"192 ","pages":"Article 112888"},"PeriodicalIF":2.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of congruence variations on a musculoskeletal model considering humeral head displacements","authors":"Margaux Peixoto ,&nbsp;Dan Soyeux ,&nbsp;Patrice Tétreault ,&nbsp;Mickaël Begon ,&nbsp;Nicola Hagemeister","doi":"10.1016/j.jbiomech.2025.112885","DOIUrl":"10.1016/j.jbiomech.2025.112885","url":null,"abstract":"<div><div>The shoulder’s large range of motion is due to the low congruency of the glenohumeral joint, whose stability relies mainly on rotator cuff muscle activity. The effect of joint congruence on shoulder biomechanics remains unclear. We used a sphere-on-sphere glenohumeral model combined with a Force-Dependent Kinematics algorithm to simulate muscle and joint forces while considering humeral head displacements. Our innovative simulations showed an increase in humeral head displacements and rotator cuff muscle forces when joint conformity decreased. Our model aligns with in vivo observations and highlights the importance of joint congruence on stability. It provides insights to improve our understanding of shoulder biomechanics.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"190 ","pages":"Article 112885"},"PeriodicalIF":2.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144781220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}