Journal of biomechanics最新文献

{"title":"Understanding muscle energy expenditure variations following selective dorsal rhizotomy while maintaining consistent energy consumption","authors":"Emiliano Pablo Ravera ,&nbsp;Adam Rozumalski","doi":"10.1016/j.jbiomech.2025.112497","DOIUrl":"10.1016/j.jbiomech.2025.112497","url":null,"abstract":"<div><div>Increased energy demands during walking is a recurrent issue for children with cerebral palsy (CP). Given the high incidence of spasticity in these children, several authors have analyzed the impact of selective dorsal rhizotomy (SDR) on energy consumption during walking, typically showing minimal changes post-SDR. To further investigate muscle behavior after SDR, our recent study identified alterations in individual muscle force production without changes in muscle activation during walking. This suggests that children with CP may experience a more favorable dynamic scenario for developing sub-maximal muscle forces after SDR, due to reduced spasticity unlocking joint movement. Thus, this raises questions about whether these changes in muscle force production could lead to increased muscle energy expenditure, which may not be fully reflected in overall energy consumption.</div><div>The aim of this study was to build upon our previous research on muscle behavior after SDR by evaluating the surgery’s impact on individual muscle energy expenditure during walking, using neuro-musculoskeletal simulations. Our research compared two matched groups comprising 81 children with CP: those who underwent SDR and those who did not.</div><div>Our results showed no significant changes in overall energy consumption or total muscle energy expenditure in either group post-surgery. However, we observed alterations in individual muscle energy expenditure during walking in the SDR group compared to children with CP who received other treatments. Compared to the findings from our first study, we observed a significant decrease in spasticity of the plantarflexor muscles, an improvement in ankle joint angle, an increase in individual muscle force during walking, and no statistically significant changes in energy expenditure of the gastrocnemius and soleus muscles post-SDR. These findings, along with the absence of changes in muscle activity post-SDR, support the hypothesis that muscle tissue alterations contribute to energy deficits observed in children with CP during walking.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"180 ","pages":"Article 112497"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological changes to peripheral joints supporting thumb trapezial metacarpal osteoarthritis","authors":"Faes D. Kerkhof ,&nbsp;Marco T.Y. Schneider ,&nbsp;Tara Shelby ,&nbsp;Arnold-Peter C. Weiss ,&nbsp;Douglas C. Moore ,&nbsp;Joseph J. Crisco ,&nbsp;Amy L. Ladd","doi":"10.1016/j.jbiomech.2025.112519","DOIUrl":"10.1016/j.jbiomech.2025.112519","url":null,"abstract":"<div><div>The present study aims to determine if morphological differences of the scaphoid, trapezoid, and second metacarpal are associated with thumb osteoarthritis by comparing three-dimensional bone models of healthy controls and osteoarthritis patients. Fifty-eight patients with moderate to severe thumb osteoarthritis (modified Eaton ≥ II) and 35 healthy controls from a larger completed investigation were examined. To quantify morphological variations, a statistical shape model was created that classified binary with respect to the Eaton grading system: non-osteoarthritis or moderate/severe osteoarthritis (II-IV). Three-dimensional surface models based on computed tomography images from the scaphoid, trapezoid, and second metacarpal were used to “train” the statistical shape model and yielded features that best explain variation within the three bones: the principal components These principal components were tested for significant differences between patient and control group. Additionally, a statistical shape model entailing all three bones was created. For the second metacarpal, only a single principal component was significantly associated with osteoarthritis (p = 0.035). The combined model utilizing all three bones, however, showed that with using one principal component of each of the bones, we could classify a sample as moderate/severe trapeziometacarpal osteoarthritis with an accuracy of 0.77. No individual shape components of the scaphoid or trapezoid significantly correlated to osteoarthritis. This study affirms that basilar thumb osteoarthritis is not limited to the trapeziometacarpal joint. Future studies investigating surrounding bones and joints as contributors to disease occurrence or progression will provide a more holistic insight into the prevention, diagnostic, and treatment of thumb osteoarthritis.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"180 ","pages":"Article 112519"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent validity of skin-based motion capture systems in measuring dynamic lumbar intervertebral angles","authors":"Mona Frey ,&nbsp;Alexander Breen ,&nbsp;Jacqueline Rix ,&nbsp;Diana De Carvalho","doi":"10.1016/j.jbiomech.2025.112503","DOIUrl":"10.1016/j.jbiomech.2025.112503","url":null,"abstract":"<div><div>Spine kinematics are commonly measured by external sensors such as motion capture and accelerometers. However, these skin-based measures cannot directly capture intervertebral motion of the lumbar spine. To date, research in this area has focused on the estimation of intervertebral kinematics using static trials but no study has analyzed agreement throughout the dynamic range of motion. This study investigated the agreement between skin-based sensors (accelerometers and motion capture) and quantitative fluoroscopy (QF) in measuring lumbar spine kinematics for the duration of complete flexion and extension motion in a healthy female population. Twenty female participants (age 30–57, BMI &lt; 30) were guided through a standing flexion and extension bending protocol while spine kinematics were concurrently measured by QF (L2, L3, L4, L5, and S1) and motion capture sensors and accelerometers positioned over the spinous processes of L2, L4, and S1. Intervertebral angles (L2-L4, L4-S1, L2-S1) and individual vertebrae levels were compared between measures. Non-parametric limits of agreement between QF and skin-based markers were greatest at the end-range of motion for both flexion and extension, but differences increased variably between participants, sometimes over-and sometimes underestimating angles, thus, disproving the common assumption that it increases linearly. The two skin-based marker systems showed good agreement with one another showing that they can be used interchangeably but they can only be used to estimate lumbar spine kinematics. Normalizing angles to a change in angle and considering the posture of instrumentation would be beneficial to reduce potential sources of errors.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"180 ","pages":"Article 112503"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accounting for fascicle curvature affects muscle architecture characterization in dynamic conditions (isokinetic contractions)","authors":"Baptiste Bizet ,&nbsp;Michele Trinchi ,&nbsp;Riccardo Magris ,&nbsp;Andrea Monte ,&nbsp;Paola Zamparo","doi":"10.1016/j.jbiomech.2025.112520","DOIUrl":"10.1016/j.jbiomech.2025.112520","url":null,"abstract":"<div><div>Investigating muscle architecture in static and dynamic conditions is essential to understand muscle function and muscle adaptations. Muscle architecture analysis, primarily through extended field-of-view ultrasound imaging, offers high reliability at rest but faces limitations during dynamic conditions. Traditional methods often involve “best fitting” straight lines to track muscle fascicles, leading to possible errors, especially with longer fascicles or those with nonlinear paths. Moreover, muscle architecture varies along the same muscle, with potential differences in curvature. This study aimed to develop and test a new software for muscle architecture characterization considering fascicle curvature during dynamic conditions. Muscle architecture data from different muscle regions using various digitalization methods were compared. Ten healthy young adults (24.1 ± 1.6 years; 177.7 ± 7.4 cm; 72.7 ± 7.7 kg; 9M/1F) performed maximal knee extension at 75°.s⁻¹ while B-mode ultrasound images of vastus lateralis muscle were captured in two muscle sites (at 50 % and 83 % of femur length). The analysis involved automated straight-line (ST) methods and custom manual linear extrapolation (MLE) software with segmented fascicle tracking using 2 (MLE2) and 4 (MLE4) segments inside the field of view. Results indicated significant overestimations of fascicle length, muscle belly length and thickness and underestimation of pennation angle using ST compared to MLE methods, especially in the distal region. Intra-rater repeatability for MLE4 was excellent (ICC = 0.93; 0.90; 0.93; 0.88, respectively; P &lt; 0.001), while inter-rater reliability varied. This study confirms the need to consider fascicle curvature for accurate resting muscle architecture characterization, even in the middle region of the muscle, and extends these considerations to dynamic conditions.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"180 ","pages":"Article 112520"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of shank, rearfoot and forefoot coordination and its variability between runners with different strike patterns","authors":"Zhen Wei ,&nbsp;Hang Xu ,&nbsp;Weiquan Zhong ,&nbsp;Lin Wang","doi":"10.1016/j.jbiomech.2025.112494","DOIUrl":"10.1016/j.jbiomech.2025.112494","url":null,"abstract":"<div><div>This study aims to compare shank, rearfoot and forefoot coordination and its variability between runners with habitual rearfoot strike (RFS) and non-RFS (NRFS). 58 healthy males participated in this study (32 RFS, 26 NRFS). Coordination patterns and variability were assessed for the shank, rearfoot, and forefoot segments using a modified vector coding technique during running. RFS runners exhibited significantly greater proportion of anti-phase with distal dominancy (rearfoot) during early and mid-stance, as well as a lower proportion of anti-phase with proximal dominancy (shank) during early stance compared to NRFS runners in frontal rearfoot − transverse shank (FRTS). Conversely, NRFS runners demonstrated significantly greater proportion of anti-phase with distal dominance (forefoot) in the sagittal, frontal, and transverse planes during early stance compared to RFS runners. Coordination variabilities for the FRTS (late stance), frontal rearfoot – frontal forefoot (FRFF) (early and late stance), and frontal rearfoot – transverse forefoot (FRTF) (mid stance) were greater in NRFS than in RFS runners. In contrast, coordination variability for frontal rearfoot – sagittal forefoot (FRSF) (early stance) was greater in RFS than in NRFS runners. The results could further extend the relationship between foot strike pattern and injuries from the perspective of coordination and its variability. Preliminary findings suggest that NRFS runners could benefit from intrinsic foot muscle training to mitigate the sustained loads on the soft tissues of the foot.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"180 ","pages":"Article 112494"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1D Network computational fluid dynamics for evaluating regional pressures in subjects with cement dust exposure","authors":"Minh Tam Tran ,&nbsp;Quoc Hung Nguyen ,&nbsp;Xinguang Cui ,&nbsp;Kum Ju Chae ,&nbsp;Sujeong Kim ,&nbsp;Ji-Seung Yoo ,&nbsp;Sanghun Choi","doi":"10.1016/j.jbiomech.2025.112501","DOIUrl":"10.1016/j.jbiomech.2025.112501","url":null,"abstract":"<div><div>Cement dust is a primary contributor to air pollution and is responsible for causing numerous respiratory diseases. The impact of cement dust exposure on the respiratory health of residents is increasing owing to the demand for construction associated with urbanization. Long-term inhalation of cement dust leads to a reduction in lung function, alterations in airway structure, increased inhalation and exhalation resistance, and heightened work of breath. In this study, we investigated the effects of cement dust exposure on lung function based on the pulmonary function test (PFT) and one-dimensional computational fluid dynamics (1D CFD). Statistical tests were performed to address the disparity of airway function between healthy and cement dust-exposed participants. The percent predicted values of forced vital capacity percent (FVC%) and forced expiratory volume in 1 s (FEV₁%) were found to be decreased in the group of dust-exposed participants. An elevation of regional pressure variation was found in cement dust-exposed airways during both inhalation and exhalation that was associated with alternations of airway structural features therein. The 1D CFD model is beneficial for a cost-effective estimation of airway regional pressure and provides valuable insights for more precise diagnosis and treatment planning in individuals exposed to cement dust.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"180 ","pages":"Article 112501"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of young adult motor fluctuation phenotypes in gait","authors":"Christopher A. Bailey,&nbsp;Alexandre Mir-Orefice,&nbsp;Julie Nantel,&nbsp;Ryan B. Graham","doi":"10.1016/j.jbiomech.2025.112523","DOIUrl":"10.1016/j.jbiomech.2025.112523","url":null,"abstract":"<div><div>Stride-to-stride fluctuations are natural in gait. These fluctuations are marked by inter-individual variability, suggesting that different fluctuation strategies (i.e., phenotypes) may exist. This study investigates the presence of gait fluctuation phenotypes. Whole-body kinematics were measured from young, healthy males and females (N = 51) while walking on a treadmill at their preferred speed. Motor fluctuation metrics (i.e., magnitude of variability, local dynamic stability, and regularity) were measured for 32 joint angles across the upper and lower body. These metrics were reduced to principal components (PCs) via principal component analysis and then grouped into clusters using the <em>k</em>-means method. One-way ANOVAs were conducted to test for cluster differences in motor fluctuation PCs. Three PCs were extracted, explaining 39.7 % of all 96 motor fluctuation metrics. Higher PC1 scores represent more fluctuation across all joints, higher PC2 scores represent greater upper limb fluctuations with fewer fluctuations in the lower limb, and PC3 scores represent less regularity in fluctuations. PC scores best grouped into four clusters in 54.0 % of iterations. Clusters 1–4 each had a significantly different PC1 score (p &lt; 0.022), and Cluster 3 had a higher PC2 score than all other clusters (p &lt; 0.022). Motor fluctuations in treadmill gait of young adults were characterised by four gait fluctuation phenotypes, interpreted as repeaters, replacers, moderate fluctuators, and mixed fluctuators (i.e. more upper limb but fewer lower limb fluctuations); extending the repeaters vs replacers hypothesis. The identified phenotypes add a new perspective that may help clarify the link between motor fluctuations and gait instability.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"180 ","pages":"Article 112523"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified chevron osteotomy for the treatment of hallux valgus with unison bioabsorbable screws: Biomechanical research and clinical applications","authors":"Changyi Liu ,&nbsp;Dongqi Li ,&nbsp;Songning Ma ,&nbsp;Hanyang Zhang ,&nbsp;Shizhong Zhang ,&nbsp;Fei Chang ,&nbsp;Peng Liu ,&nbsp;Hongwei Zhao ,&nbsp;Shuo Jin","doi":"10.1016/j.jbiomech.2025.112527","DOIUrl":"10.1016/j.jbiomech.2025.112527","url":null,"abstract":"<div><div>Researchers have modified PLA materials to enhance their mechanical properties and meet the clinical requirements. However, the strength and stiffness of PLA are still significantly lower than those of metals. Building on the established chevron clinical procedure and considering the mechanical characteristics of PLA screws, we devised a modified chevron osteotomy (MCO) based on a load-reducing structure with the aim of reducing the load on the screws. Subsequently, in vitro quasi-static in situ compression and dynamic fatigue tests were conducted for both procedures. DIC, micro-CT, and SEM were used to elucidate the unloading effects and structural damage of different bone cutting and implant locations on the PLA bone screws, providing biomechanical data for clinical applications. In-vitro simulation studies indicated that the unloading structure of the MCO procedure reduced the load borne by the PLA screws. Within the load range of the first metatarsal during walking, the MCO procedure exhibited a compressive strength 2.5 times that of the traditional chevron osteotomy groups and even exceeded the titanium alloy screw groups by 25%, ensuring PLA screw fixation strength and stability that are not inferior to metallic materials. A stable load-reducing structure in osteotomy procedures is the key to PLA materials becoming viable alternatives to metal orthopedic fixation devices.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"180 ","pages":"Article 112527"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliable and streamlined model setup for digital twin assessment of fracture healing","authors":"Mehran Bahrami ,&nbsp;Kylie Frew ,&nbsp;John Hughes ,&nbsp;Hannah L. Dailey","doi":"10.1016/j.jbiomech.2025.112492","DOIUrl":"10.1016/j.jbiomech.2025.112492","url":null,"abstract":"<div><div>In large animal models of bone fracture repair, postmortem torsional testing is commonly used to assess healing biomechanics. Bending and axial tests are physiologically relevant, but much less commonly performed. Virtual torsional testing using image-based finite element models has been validated to postmortem bench tests, but its predictive value for capturing whole-bone mechanics and fracture healing quality under other physiologically relevant loading modes has not yet been established. Accordingly, the purpose of this study was to evaluate the association between mechanical biomarkers derived from virtual torsion, axial, and bending tests under strict alignment and malalignment conditions. Computed tomography (CT) scans from 24 intact and operated sheep tibiae and 29 human tibial fractures were used to create digital twins that were subjected to torsion, axial, and bending tests. The results indicated that torsional rigidity is a strong surrogate for bending flexural rigidity in both ovine and human bones. Torsional rigidity and axial stiffness were strongly correlated in the ovine data, but only moderately in human fractures due to the complex fracture patterns. Axial testing was highly prone to stiffness estimation errors as high as 50% if the applied load and anatomic axis were not perfectly aligned. In contrast, torsional rigidity had errors &lt;1.3% for all malalignment scenarios. Based on this study, virtual torsional rigidity is the recommended summary mechanical biomarker of bone healing because it captures variations in healing biomechanics that are present in other loading modes with a simple setup that is insensitive to alignment error.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"180 ","pages":"Article 112492"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BIASMECHANICS: Does an unconscious bias still persist in biomechanics, positioning males as the default in human research? A meta-analysis on the Journal of Biomechanics 2024 publications","authors":"Eline van der Kruk","doi":"10.1016/j.jbiomech.2025.112560","DOIUrl":"10.1016/j.jbiomech.2025.112560","url":null,"abstract":"<div><div>Articles published in the Journal of Biomechanics still reflect bias, with males positioned as the default in human research. This meta-analysis on the 2024 articles reveals a large disparity in female representation. One in four studies showed an imbalance (&lt;30 % female representation) favouring male participants, while only 8 % favoured females. Male-only studies outnumbered female-only studies by over fivefold. Of particular concern is that male-only studies often lack justification for their single-gender focus, whereas female-only studies typically provide clear reasoning. This inconsistency not only lacks accountability but also reinforces the notion that male data is the standard in biomechanics research. I named this issue<!--> <em>bias</em>mechanics<!--> <!-->to encourage efforts to address them. While there are valid scientific reasons for focusing on specific gender/sex groups, this should not be the default. Authors must consider sex- and gender-based differences, and reviewers and editors should adopt stricter standards for accepting articles with unjustified imbalances. The <em>Journal of Biomechanics</em> could establish standardized guidelines promoting equitable representation in research. Exclusions of any sex or gender must include clear scientific justification in the introduction and methodology sections. The discussion and limitations sections should assess the implications of such exclusions, including their effects on validity, generalizability, and bias. If appropriate, titles and abstracts should clearly indicate single-sex or gender-specific studies to ensure transparency about the research’s scope and applicability. By collectively affirming as a scientific community that, except for legitimate scientific justification, we oppose the exclusion of female participants, we can shift the default approach in our research studies.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"181 ","pages":"Article 112560"},"PeriodicalIF":2.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}