Journal of biomechanics最新文献_第9页

Predicting human gait kinematics and kinetics from a single inertial measurement unit using deep learning and synthetic datasets: A blinded assessment study 使用深度学习和合成数据集从单个惯性测量单元预测人类步态运动学和动力学：一项盲法评估研究

IF 2.4 3区医学

Journal of biomechanics Pub Date : 2026-03-01 Epub Date: 2026-01-06 DOI: 10.1016/j.jbiomech.2026.113149

Metin Bicer , Andrew TM Phillips , Oğuz Faik Seven , Matthew Banger , Alison H McGregor , Luca Modenese

{"title":"Predicting human gait kinematics and kinetics from a single inertial measurement unit using deep learning and synthetic datasets: A blinded assessment study","authors":"Metin Bicer , Andrew TM Phillips , Oğuz Faik Seven , Matthew Banger , Alison H McGregor , Luca Modenese","doi":"10.1016/j.jbiomech.2026.113149","DOIUrl":"10.1016/j.jbiomech.2026.113149","url":null,"abstract":"<div><div>A single inertial measurement unit (IMU) can be used with neural networks (NNs) to predict joint kinematics and kinetics. Recent studies, however, often employed virtual IMU data computed from marker-based systems to train NN models, without providing realistic performance assessments on real IMU data. To address this, we present a methodology for developing and blindly evaluating NNs predicting lower-limb joint angles and moments from a sacrum-worn IMU.</div><div>NN architectures were trained on IMU data simulated from a public marker-based dataset (49 healthy adults), augmented using conditional generative adversarial networks to enhance variability. The developed NNs were blindly tested against a different dataset (seven healthy adults) of real IMU and synchronous marker-based data collected <em>ad hoc</em> after the NN development. The two datasets were collected in different labs using different protocols. These NNs were subsequently fine-tuned (retrained) with this dataset and re-evaluated on another real IMU data (three healthy adults) collected after fine-tuning.</div><div>The NNs achieved strong predictive performance on virtual IMU data (average root mean squared error (RMSE) of 2.6±1.3° and 0.10±0.05 Nm/kg for joint angles and moments, respectively). However, performance degraded when applied to real IMU data: average RMSE of 4.5±2.0° for joint angles and 0.21±0.14 Nm/kg for moments. Fine-tuning with real IMU data improved model accuracy, recovering RMSEs to 2.6±0.8° and 0.19±0.11 Nm/kg for joint angles and moments, respectively.</div><div>Overall, our performance metrics were within the reported ranges for systems employing multiple IMU sensors. This work highlights the importance of blinded assessment and fine-tuning for practical biomechanical applications.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"198 ","pages":"Article 113149"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered Gait and Total Ankle Arthroplasty Influence Ankle and Hindfoot Joint Kinematics during Cadaveric Simulations of Level Walking 在水平行走的尸体模拟中，步态改变和全踝关节置换术对踝关节和后足关节运动学的影响

IF 2.4 3区医学

Journal of biomechanics Pub Date : 2026-03-01 Epub Date: 2026-02-01 DOI: 10.1016/j.jbiomech.2026.113165

Brett D. Steineman, Jaeyoung Kim, Jeffrey W. Hoffman, Joaquin Palma, Jensen K. Henry, Scott J. Ellis, Jonathan T. Deland, Constantine A. Demetracopoulos

{"title":"Altered Gait and Total Ankle Arthroplasty Influence Ankle and Hindfoot Joint Kinematics during Cadaveric Simulations of Level Walking","authors":"Brett D. Steineman, Jaeyoung Kim, Jeffrey W. Hoffman, Joaquin Palma, Jensen K. Henry, Scott J. Ellis, Jonathan T. Deland, Constantine A. Demetracopoulos","doi":"10.1016/j.jbiomech.2026.113165","DOIUrl":"10.1016/j.jbiomech.2026.113165","url":null,"abstract":"<div><div>The progression of ankle arthritis causes altered gait patterns to develop that persist even after total ankle arthroplasty (TAA) and rehabilitation, although the contributions of altered gait and implantation to this persistence are unknown. The objective of this study was to quantify changes in joint kinematics resulting from the combined and individual contributions of total ankle implantation and gait alterations during simulated level walking. Twelve cadaveric feet were tested on a six-degree-of-freedom robot to simulate level walking in four conditions: intact with healthy gait (Intact-Healthy), intact with altered gait (Intact-Altered), implanted with healthy gait (TAA-Healthy), and implanted with altered gait (TAA-Altered). Nonparametric 95% confidence intervals for paired samples were calculated for the kinematics of the ankle, subtalar, and talonavicular joints in each condition. Isolated implantation and altered gait conditions changed ankle and hindfoot joint kinematics during simulated level walking. The ankle joint was more dorsiflexed, everted, and internally rotated due to altered gait, while implantation largely corrected the rotational changes induced by it. Altered gait increased subtalar eversion, dorsiflexion, and external rotation in late stance, whereas implantation either exacerbated these changes or failed to correct them. Implantation and altered gait increased talonavicular joint abduction and eversion across different portions of the stance phase, with increased dorsiflexion in late stance due to altered gait, a change mitigated by implantation. The combination of these factors largely corrected ankle kinematics but often exacerbated kinematic changes in the hindfoot joints and should be considered in the design and evaluation of implants.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"198 ","pages":"Article 113165"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanotransduction in trabecular meshwork cells: Rho/ROCK-dependent responses to substrate stiffness 小梁网细胞的机械转导：Rho/ rock对基质刚度的依赖反应

IF 2.4 3区医学

Journal of biomechanics Pub Date : 2026-03-01 Epub Date: 2026-01-12 DOI: 10.1016/j.jbiomech.2026.113164

Ruotian Du , Jing Ji , Dongyan Li , Long Li , Fan Song , Yubo Fan

{"title":"Mechanotransduction in trabecular meshwork cells: Rho/ROCK-dependent responses to substrate stiffness","authors":"Ruotian Du , Jing Ji , Dongyan Li , Long Li , Fan Song , Yubo Fan","doi":"10.1016/j.jbiomech.2026.113164","DOIUrl":"10.1016/j.jbiomech.2026.113164","url":null,"abstract":"<div><div>Elevated intraocular pressure (IOP) is a major risk factor for glaucoma. Trabecular meshwork cells (TMCs) play a crucial role in modulating IOP by regulating the aqueous outflow resistance. In glaucoma, the stiffening of trabecular meshwork (TM) tissue is believed to affect aqueous humor outflow, highlighting the importance of substrate stiffness in influencing TMC behavior. However, the molecular mechanisms by which substrate stiffness impacts TMCs are still not fully understood. This study investigates the role of the Rho/ROCK pathway in the effect of substrate stiffness on TMCs. Human TMCs (hTMCs) and porcine TMCs (pTMCs) were cultured on substrates of varying stiffness with Rho/ROCK pathway inhibitor Y-27632 to assess the alterations in Rho/ROCK pathway molecules, cytoskeletal organization, and cellular functions. The results indicate that stiffer substrates generally lead to decreased ROCK levels, multi-oriented F-actin organization, increased cellular contraction, and enhanced cell migration. Notably, these effects were diminished or negated by Rho/ROCK pathway inhibition, which suggests that the Rho/ROCK pathway is at least partially responsible for mediating substrate stiffness affecting TMC behavior. This study highlights the significance of the mechano-microenvironment of the TM in glaucoma pathogenesis and deepens the understanding of the Rho/ROCK pathway as a promising therapeutic target for glaucoma treatment.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"198 ","pages":"Article 113164"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the mechanical language of the tumor microenvironment: From physical forces to malignant behaviors 解读肿瘤微环境的机械语言：从物理力量到恶性行为

IF 2.4 3区医学

Journal of biomechanics Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI: 10.1016/j.jbiomech.2026.113170

Luyao Zhao , Yifan Han , Jing Du , Xinbin Zhao

{"title":"Decoding the mechanical language of the tumor microenvironment: From physical forces to malignant behaviors","authors":"Luyao Zhao , Yifan Han , Jing Du , Xinbin Zhao","doi":"10.1016/j.jbiomech.2026.113170","DOIUrl":"10.1016/j.jbiomech.2026.113170","url":null,"abstract":"<div><div>Malignant metastasis, the leading cause of cancer mortality, is initiated by tumor invasion, a process intrinsically linked to dynamic biomechanical alterations within the tumor microenvironment (TME). While recent reviews have established the role of extracellular matrix (ECM) stiffness, this review offers a distinct synthesis by focusing on the synergistic interplay between two critical, yet underappreciated, mechanical forces: solid stress and fluid pressure. We propose that these forces form an integrated mechanical barrier that actively promotes malignancy. As tumors grow, ECM deposition and spatial confinement generate substantial solid stress, while vascular dysfunction elevates fluid stress. This review uniquely details how this solid–fluid stress nexus drives malignant progression, immune suppression, and therapeutic resistance through coordinated mechanobiological signaling. We comprehensively synthesize how these altered forces regulate tumor cell behavior by focusing on mechanotransduction—the conversion of mechanical cues into biochemical signals. Finally, we outline a framework for novel therapeutic strategies that target this “physical barrier”, with the goal of improving drug delivery, overcoming resistance, and advancing cancer treatment.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"197 ","pages":"Article 113170"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanical stability and pedicle screw loosening 生物力学稳定性和椎弓根螺钉松动

IF 2.4 3区医学

Journal of biomechanics Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI: 10.1016/j.jbiomech.2026.113174

Chenxi Cui, Haisheng Yang

{"title":"Biomechanical stability and pedicle screw loosening","authors":"Chenxi Cui, Haisheng Yang","doi":"10.1016/j.jbiomech.2026.113174","DOIUrl":"10.1016/j.jbiomech.2026.113174","url":null,"abstract":"<div><div>Pedicle screws are widely utilized in spinal surgeries, yet postoperative loosening remains a major complication in clinical practice. A better understanding of the screw loosening mechanisms will aid the development of proper approaches to predict screw loosening and to reduce the loosening rate. From a unique perspective of biomechanical stability, this review is motivated to provide insights into the mechanisms of pedicle screw loosening, methods to predict screw loosening risk, and strategies to reduce screw loosening risk. The biomechanical stability of screw includes primary stability and secondary stability, which are closely associated with screw loosening and affected by multiple factors, such as bone mineral density, screw parameters, osseointegration, and stress shielding. To assess the risk of pedicle screw loosening, radiographic evaluation and several <em>in vivo</em> (e.g., acoustic modal analysis and resonance frequency analysis), <em>in vitro</em> (e.g., biomechanical testing), and <em>in silico</em> (e.g., finite element analysis) approaches are available. Regarding the strategies to reduce the screw loosening rate, advancements in screw material, surface modification, structural design, and bone cement augmentation have demonstrated promising potential, while optimization of preoperative planning as well as robot- and augmented reality-assisted surgical techniques have significantly improved the implantation accuracy. It can be found that current research has achieved notable progress in improving the primary biomechanical stability of the pedicle screw. However, how to enhance the mechanobiological osseointegration of the bone-screw interface to achieve an improved secondary biomechanical stability for the screws, ultimately reducing the risk of long-term screw loosening, remains a question requiring further studies.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"197 ","pages":"Article 113174"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of a supine straight-leg thrust in managing knee joint dysfunction in knee osteoarthritis: A biomechanical study 仰卧直腿推力治疗膝关节骨性关节炎的治疗潜力：一项生物力学研究

IF 2.4 3区医学

Journal of biomechanics Pub Date : 2026-03-01 Epub Date: 2026-01-22 DOI: 10.1016/j.jbiomech.2026.113183

Xiaolong Zeng , Shiyang Chen , Qingyang Kang , Wenjia Zhou , Zhilin Ge , Ruotong Liao , Xin Zhang , Shunying Huang , Guoyi Su , Fangzheng Lin , Yongjin Li , Dingkun Lin

{"title":"Therapeutic potential of a supine straight-leg thrust in managing knee joint dysfunction in knee osteoarthritis: A biomechanical study","authors":"Xiaolong Zeng , Shiyang Chen , Qingyang Kang , Wenjia Zhou , Zhilin Ge , Ruotong Liao , Xin Zhang , Shunying Huang , Guoyi Su , Fangzheng Lin , Yongjin Li , Dingkun Lin","doi":"10.1016/j.jbiomech.2026.113183","DOIUrl":"10.1016/j.jbiomech.2026.113183","url":null,"abstract":"<div><div>Rehabilitation of knee osteoarthritis is often constrained by limited understanding of muscle activation patterns and active joint mobilization mechanisms. The supine straight-leg thrust (SST) exercise, previously introduced by our team, has shown promising clinical effects, yet its neuromuscular and kinematic mechanisms remain unclear. This study aims to investigate quadriceps-hamstring activation and knee joint kinematics during SST using synchronized surface electromyography and three-dimensional motion capture, and to compare its biomechanical effects with walking, squatting, and supine air cycling (SAC).</div><div>Fifteen healthy adults performed walking, squatting, SST, and SAC exercises. Surface electromyography data of the quadriceps and hamstrings, and three-dimensional kinematic data of the tibiofemoral and patellofemoral joints were collected. Comparisons were made across tasks to evaluate muscle activation levels and multi-planar joint range of motion.</div><div>SST elicited significantly greater activation of the rectus femoris, vastus medialis, and vastus lateralis compared to walking (<em>P</em> < 0.05), with levels comparable to squatting. SST also produced significantly larger ranges of motion in both tibiofemoral and patellofemoral joints than walking and squatting (<em>P</em> < 0.05). Compared to SAC, SST resulted in higher thigh muscle activation and more favorable joint mobility (<em>P</em> < 0.05).</div><div>SST effectively activates key quadriceps muscles and enhances multi-planar knee joint mobility, outperforming walking, squatting, and SAC. These findings support the biomechanical rationale for SST as a targeted exercise for addressing joint dysfunction in knee osteoarthritis rehabilitation.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"197 ","pages":"Article 113183"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gait recovery after total hip arthroplasty: insights from principal component analysis of pre- and post-surgical walking performance 全髋关节置换术后步态恢复：来自术前和术后行走表现的主成分分析的见解。

IF 2.4 3区医学

Journal of biomechanics Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.jbiomech.2026.113173

Arunee Promsri , Inge Werner , Peter Federolf

{"title":"Gait recovery after total hip arthroplasty: insights from principal component analysis of pre- and post-surgical walking performance","authors":"Arunee Promsri , Inge Werner , Peter Federolf","doi":"10.1016/j.jbiomech.2026.113173","DOIUrl":"10.1016/j.jbiomech.2026.113173","url":null,"abstract":"<div><div>Total hip arthroplasty (THA) alleviates pain and restores function in hip osteoarthritis, yet gait abnormalities may persist. We tested two hypotheses: (H1) THA patients would improve from preoperative (M0) to six months postoperative (M6) in principal component analysis (PCA)–derived gait outcomes; (H2) despite improvement, patients at M6 would still differ from healthy adults. Full-body overground kinematics from 50 THA patients (64.9 ± 9.9 years) and 50 healthy adults (64.5 ± 8.9 years) were decomposed using PCA into coordinated movement components (“principal movements,” PMs). Each PM was quantified by the relative explained variance (rVAR; structural contribution), the number of zero-crossings of PM accelerations (N; control reversals/smoothness), and the root-mean-square of PM accelerations (RMS; acceleration magnitude). The first five PMs (PM<sub>1–5</sub>) mapped to recognizable phases: PM<sub>1</sub>—forward progression/propulsion; PM<sub>2</sub>—swing-phase movement; PM<sub>3</sub>—single-leg support with mediolateral stabilization; PM<sub>4</sub>—single-leg support with trunk rotation; PM<sub>5</sub>—double-support transition. Consistent with H1, from M0 to M6 patients showed increased PM<sub>2</sub> rVAR (<em>p</em> = 0.005), reduced N across all PMs (all <em>p</em> ≤ 0.003), and reduced RMS in PM<sub>3–5</sub> (<em>p</em> ≤ 0.001). Consistent with H2, at M6 patients still exhibited a trend in higher rVAR (unadjusted <em>p</em> = 0.022; not significant after multiplicity control) and significantly higher RMS (<em>p</em> = 0.002) in PM<sub>3</sub> versus healthy adults. These findings indicate that THA yields substantial gains over six months—particularly in swing-phase structure and overall smoothness—yet phase-specific deviations persist during single-leg support (mediolateral stabilization), highlighting targets for extended rehabilitation to improve walking performance.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"197 ","pages":"Article 113173"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of combined active knee exercise and high-intensity continuous ultrasound on infrapatellar fat pad stiffness and gliding in healthy participants: A randomised, single-blind, placebo-controlled crossover trial 联合积极膝关节运动和高强度连续超声对健康参与者髌下脂肪垫硬度和滑动的影响：一项随机、单盲、安慰剂对照交叉试验

IF 2.4 3区医学

Journal of biomechanics Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.jbiomech.2026.113191

Naoto Ikeda , Taizan Fukaya , Yui Sezaki , Sho Toyoshima , Yukiho Ichikawa , Yuka Yokoi , Katsuyuki Morishita

{"title":"Effects of combined active knee exercise and high-intensity continuous ultrasound on infrapatellar fat pad stiffness and gliding in healthy participants: A randomised, single-blind, placebo-controlled crossover trial","authors":"Naoto Ikeda , Taizan Fukaya , Yui Sezaki , Sho Toyoshima , Yukiho Ichikawa , Yuka Yokoi , Katsuyuki Morishita","doi":"10.1016/j.jbiomech.2026.113191","DOIUrl":"10.1016/j.jbiomech.2026.113191","url":null,"abstract":"<div><div>Reduced flexibility of the infrapatellar fat pad (IFP) contributes to anterior knee pain. High-intensity continuous ultrasound (HICUS) decreases IFP stiffness and improves gliding. However, the effect of combining exercise therapy with HICUS remains unclear. We conducted a randomised, single-blind, placebo-controlled crossover trial involving 20 healthy participants to evaluate the effects of combined active knee exercise and HICUS on IFP stiffness and gliding. Healthy participants received active knee exercise with HICUS and sham HICUS on separate days. HICUS was applied at 1 MHz, 2.5 W/cm<sup>2</sup>, 100% duty cycle for 5 min using an ultrasound unit with automatic rotation. The main outcomes were IFP stiffness at 10° and 120° knee flexion and IFP gliding. Measurements were taken before (T1), immediately after (T2), and 15 min after (T3) ultrasound irradiation. IFP stiffness at 10° knee flexion decreased from T1 (13.6 ± 1.7) to T2 (9.4 ± 0.8) under HICUS conditions. At 120° knee flexion, IFP stiffness decreased from T1 (57.5 ± 12.8) to T2 (31.6 ± 6.5) and T3 (36.8 ± 12.1) under HICUS conditions. IFP gliding improved from T1 (29.6 ± 1.3) to T2 (34.7 ± 1.3) and T3 (32.8 ± 1.4) under HICUS conditions and from T1 (29.2 ± 1.5) to T2 (30.9 ± 1.2) under placebo conditions. These findings suggest that combined active knee exercise and HICUS is a safe, effective short-term intervention to reduce IFP stiffness and improve gliding. Further studies involving patients with knee osteoarthritis are needed to validate its clinical applicability.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"198 ","pages":"Article 113191"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural network surrogates for musculoskeletal models: An application to implant alignment in total knee arthroplasty 神经网络替代肌肉骨骼模型：全膝关节置换术中植入物对齐的应用。

IF 2.4 3区医学

Journal of biomechanics Pub Date : 2026-03-01 Epub Date: 2026-02-14 DOI: 10.1016/j.jbiomech.2026.113214

Linda ten Klooster , Periklis Tzanetis , Dennis Janssen , Thom Bitter , Jelmer M. Wolterink

{"title":"Neural network surrogates for musculoskeletal models: An application to implant alignment in total knee arthroplasty","authors":"Linda ten Klooster , Periklis Tzanetis , Dennis Janssen , Thom Bitter , Jelmer M. Wolterink","doi":"10.1016/j.jbiomech.2026.113214","DOIUrl":"10.1016/j.jbiomech.2026.113214","url":null,"abstract":"<div><div>Total knee arthroplasty (TKA) is an effective treatment for end-stage knee osteoarthritis (OA). However, dissatisfaction persists in one in five patients. Musculoskeletal model-based approaches have the potential to predict implant alignment that restores pre-diseased knee functioning and improves patient satisfaction, but their computational complexity limits clinical application. This study aimed to accelerate the estimation of optimal implant alignment using a neural network-based surrogate model, which provides an assessment of the kinematics and ligament strains associated with a candidate alignment. A dataset of eight knee OA patients, including implant positions and the deviations in kinematics and ligament strains between implanted and pre-diseased models, was used to train a multi-task multilayer perceptron (MLP). One MLP was trained per patient to predict implant position quality as quantified by kinematics and ligament strains. A gradient-based optimization method was then applied to the output of the MLP to identify optimal implant positions. Strong correlations were observed between predicted and computed values across all patients. The gradient-based optimization revealed either a single or multiple optimal positions per patient, depending on the geometry of the loss landscape. This reflects the model’s ability to capture regions of biomechanical equivalence, as also observed in the musculoskeletal simulations. This proof-of-principle study was designed for patient-specific modeling and therefore focuses on individual optimization rather than generalization to new patients. This study is a critical step toward using biomechanical modeling for the determination of patient-specific optimal implant alignment during TKA in a clinical setting.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"198 ","pages":"Article 113214"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146226930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of automatic identification of events during the lunge exercise using kinematic data 利用运动学数据评估弓步运动中事件的自动识别。

IF 2.4 3区医学

Journal of biomechanics Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.jbiomech.2026.113192

Mitchell Nienhuis , Joseph Signorile , Zachary Ripic , Brandon Schoenwether , Soyeon Ahn , Kevin Jacobs , Moataz Eltoukhy

引用次数: 0