International review of cell and molecular biology最新文献_第7页

Cancer-cell-intrinsic mechanisms regulate MDSCs through cytokine networks. 癌细胞内在机制通过细胞因子网络调节MDSCs。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2022.09.001

Yuting Zhang, Sean Murphy, Xin Lu

引用次数: 0

Role of mitochondria in regulating immune response during bacterial infection. 线粒体在细菌感染期间调节免疫反应中的作用。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2022.10.004

Shaziya Khan, Swarnali Basu, Desh Raj, Amit Lahiri

{"title":"Role of mitochondria in regulating immune response during bacterial infection.","authors":"Shaziya Khan, Swarnali Basu, Desh Raj, Amit Lahiri","doi":"10.1016/bs.ircmb.2022.10.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2022.10.004","url":null,"abstract":"Mitochondria are dynamic organelles of eukaryotes involved in energy production and fatty acid oxidation. Besides maintaining ATP production, calcium signaling, cellular apoptosis, and fatty acid synthesis, mitochondria are also known as the central hub of the immune system as it regulates the innate immune pathway during infection. Mitochondria mediated immune functions mainly involve regulation of reactive oxygen species production, inflammasome activation, cytokine secretion, and apoptosis of infected cells. Recent findings indicate that cellular mitochondria undergo constant biogenesis, fission, fusion and degradation, and these dynamics regulate cellular immuno-metabolism. Several intracellular pathogens target and modulate these normal functions of mitochondria to facilitate their own survival and growth. De-regulation of mitochondrial functions and dynamics favors bacterial infection and pathogens are able to protect themselves from mitochondria mediated immune responses. Here, we will discuss how mitochondria mediated anti-bacterial immune pathways help the host to evade pathogenic insult. In addition, examples of bacterial pathogens modulating mitochondrial metabolism and dynamics will also be elaborated. Study of these interactions between the mitochondria and bacterial pathogens during infection will lead to a better understanding of the mitochondrial metabolism pathways and dynamics important for the establishment of bacterial diseases. In conclusion, detailed studies on how mitochondria regulate the immune response during bacterial infection can open up new avenues to develop mitochondria centric anti-bacterial therapeutics.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"374 ","pages":"159-200"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9822363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Armored modified vaccinia Ankara in cancer immunotherapy. 装甲修饰安卡拉牛痘在癌症免疫治疗中的应用。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.05.003

Cigdem Atay, José Medina-Echeverz, Hubertus Hochrein, Mark Suter, Maria Hinterberger

{"title":"Armored modified vaccinia Ankara in cancer immunotherapy.","authors":"Cigdem Atay, José Medina-Echeverz, Hubertus Hochrein, Mark Suter, Maria Hinterberger","doi":"10.1016/bs.ircmb.2023.05.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.05.003","url":null,"abstract":"Cancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. Cancer vaccines aim to stimulate both the innate and adaptive arms of immunity to achieve durable clinical responses. Some roadblocks for a successful cancer vaccine in the clinic include the tumor antigen of choice, the adjuvants employed to strengthen antitumor-specific immune responses, and the risks associated with enhancing immune-related adverse effects in patients. Modified vaccinia Ankara (MVA) belongs to the family of poxviruses and is a versatile vaccine platform that combines several attributes crucial for cancer therapy. First, MVA is an excellent inducer of innate immune responses leading to type I interferon secretion and induction of T helper cell type 1 (Th1) immune responses. Second, it elicits robust and durable humoral and cellular immunity against vector-encoded heterologous antigens. Third, MVA has enormous genomic flexibility, which allows for the expression of multiple antigenic and costimulatory entities. And fourth, its replication deficit in human cells ensures a excellent safety profile. In this review, we summarize the current understanding of how MVA induces innate and adaptive immune responses. Furthermore, we will give an overview of the tumor-associated antigens and immunomodulatory molecules that have been used to armor MVA and describe their clinical use. Finally, the route of MVA immunization and its impact on therapeutic efficacy depending on the immunomodulatory molecules expressed will be discussed.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"379 ","pages":"87-142"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9942934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can we define breast cancer HER2 status by liquid biopsy? 我们可以通过液体活检来确定癌症HER2状态吗？

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-09-04 DOI: 10.1016/bs.ircmb.2023.07.003

Serena Di Cosimo, Cinzia De Marco, Marco Silvestri, Adele Busico, Andrea Vingiani, Giancarlo Pruneri, Vera Cappelletti

{"title":"Can we define breast cancer HER2 status by liquid biopsy?","authors":"Serena Di Cosimo, Cinzia De Marco, Marco Silvestri, Adele Busico, Andrea Vingiani, Giancarlo Pruneri, Vera Cappelletti","doi":"10.1016/bs.ircmb.2023.07.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.07.003","url":null,"abstract":"Human Epidermal growth factor Receptor 2 (HER2) assessment is crucial for breast cancer treatment. Therapeutic decisions for recurrent cases often rely on primary tumor status. However, mounting evidence suggests that tumors show dynamic changes and up to 10% of breast cancer modify their initial status during progression. It is still debated whether these changes reflect a biological evolution of the disease or are secondary to primary tumor heterogeneity. Certainly, repeating HER2 assessment during breast cancer trajectory is important for the increasing availability of effective anti-HER2 drugs. In response to this need, circulating biomarkers such as circulating tumor cells (CTCs) and cell-free circulating tumor DNA (ctDNA) offer the potential to safely and repeatedly assess HER2 status over time. This chapter outlines current methods for testing HER2 in CTCs and ctDNA, and reviews clinical trials evaluating its prognostic and predictive value in patients with breast cancer, as well as recent advances in the field.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"381 ","pages":"23-56"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41113237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Circulating tumor cells and host immunity: A tricky liaison. 循环肿瘤细胞和宿主免疫：一个棘手的联系。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-08-12 DOI: 10.1016/bs.ircmb.2023.07.002

Elena Muraro, Giulia Brisotto

引用次数: 0

Immunomodulatory effects of targeted radionuclide therapy. 靶向放射性核素治疗的免疫调节作用。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.02.001

J Constanzo, Y Bouden, L Godry, P-O Kotzki, E Deshayes, J-P Pouget

引用次数: 0

Myeloid-derived suppressor cells: A new emerging player in endometriosis. 髓源性抑制细胞:子宫内膜异位症的新参与者。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2022.11.004

Tao Zhang, Ying He, Gene Chi Wai Man, Yang Ding, Chi Chiu Wang, Jacqueline Pui Wah Chung

{"title":"Myeloid-derived suppressor cells: A new emerging player in endometriosis.","authors":"Tao Zhang, Ying He, Gene Chi Wai Man, Yang Ding, Chi Chiu Wang, Jacqueline Pui Wah Chung","doi":"10.1016/bs.ircmb.2022.11.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2022.11.004","url":null,"abstract":"Endometriosis is a common gynecological disorder defined by the presence of endometrial tissue outside the uterus. This is commonly associated with chronic pelvic pain, infertility, and dysmenorrhea, which occurs in approximately 10% of women of reproductive age. Although the exact mechanism remains uncertain, it has been widely accepted to be an estrogen-dependent and inflammatory disease. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immune cells with immunosuppressive capacity and non-immunological functions. They have been found to be aggressively involved in the pathologies of various disorders. In regards to tumors, the functions of MDSCs have been profoundly shown to inhibit tumor immune response and to promote angiogenesis, tumor metastasis, fibrosis, and epithelial-mesenchymal transition (EMT). In recent years, the elevation of MDSCs in endometriosis was reported by several studies that provoke the assumption that MDSCs might exert similar roles to promote the development of endometriosis. Such that, precision treatments targeting MDSCs might be a promising direction for future study. Herein, we will review the research progress of MDSCs in endometriosis and its potential relevance to the pathogenesis, progression, and therapeutics strategy of endometriosis.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"375 ","pages":"191-220"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9506634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Radio-induced lymphopenia in the era of anti-cancer immunotherapy. 抗癌免疫治疗时代的放射性淋巴细胞减少症。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.03.002

François de Kermenguy, Lydia Meziani, Michele Mondini, Céline Clémenson, Daphné Morel, Eric Deutsch, Charlotte Robert

引用次数: 1

Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer. 癌症早期转移性循环肿瘤细胞临床研究的最新进展。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-09-01 DOI: 10.1016/bs.ircmb.2023.07.005

Laura S Munoz-Arcos, Eleonora Nicolò, Mara S Serafini, Lorenzo Gerratana, Carolina Reduzzi, Massimo Cristofanilli

引用次数: 0

Attaching and effacing pathogens modulate host mitochondrial structure and function. 病原体的附着和脱落会调节宿主线粒体的结构和功能。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-04-03 DOI: 10.1016/bs.ircmb.2023.03.001

Anusha Harishankar, V K Viswanathan

{"title":"Attaching and effacing pathogens modulate host mitochondrial structure and function.","authors":"Anusha Harishankar, V K Viswanathan","doi":"10.1016/bs.ircmb.2023.03.001","DOIUrl":"10.1016/bs.ircmb.2023.03.001","url":null,"abstract":"Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) are human enteric pathogens that contribute significantly to morbidity and mortality worldwide. These extracellular pathogens attach intimately to intestinal epithelial cells and cause signature lesions by effacing the brush border microvilli, a property they share with other \"attaching and effacing\" (A/E) bacteria, including the murine pathogen Citrobacter rodentium. A/E pathogens use a specialized apparatus called a type III secretion system (T3SS) to deliver specific proteins directly into the host cytosol and modify host cell behavior. The T3SS is essential for colonization and pathogenesis, and mutants lacking this apparatus fail to cause disease. Thus, deciphering effector-induced host cell modifications is critical for understanding A/E bacterial pathogenesis. Several of the ∼20-45 effector proteins delivered into the host cell modify disparate mitochondrial properties, some via direct interactions with the mitochondria and/or mitochondrial proteins. In vitro studies have uncovered the mechanistic basis for the actions of some of these effectors, including their mitochondrial targeting, interaction partners, and consequent impacts on mitochondrial morphology, oxidative phosphorylation and ROS production, disruption of membrane potential, and intrinsic apoptosis. In vivo studies, mostly relying on the C. rodentium/mouse model, have been used to validate a subset of the in vitro observations; additionally, animal studies reveal broad changes to intestinal physiology that are likely accompanied by mitochondrial alterations, but the mechanistic underpinnings remain undefined. This chapter provides an overview of A/E pathogen-induced host alterations and pathogenesis, specifically focusing on mitochondria-targeted effects.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"377 ","pages":"65-86"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10119158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0