炎症性乳腺癌:组织病理学和诊断概述。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Ghada Sahraoui, Nabil Rahoui, Maha Driss, Karima Mrad
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引用次数: 0

摘要

炎性乳腺癌(IBC)是一种罕见的侵袭性局部晚期乳腺癌,根据肿瘤-结节-转移分期标准被归类为 T4d 期。与其他形式的乳腺癌相比,这种亚型乳腺癌因其进展迅速和生存率明显较低而闻名。尽管世界卫生组织列出了其独特的临床特征,但 IBC 的组织病理学特征仍未完全阐明,这给其诊断和治疗带来了挑战。从组织学角度看,IBC 肿瘤通常表现为导管表型,其特征是由核级较高的多形性细胞组成的栓子。这些栓子主要出现在乳腺上方皮肤的乳头状真皮层和网状真皮层,表明淋巴管主要受累。IBC 的肿瘤微环境是一个复杂的网络,涉及各种细胞,如巨噬细胞、单核细胞和以 T 细胞为主的 CD8+ 淋巴细胞,以及包括血管和细胞外基质分子在内的各种因素,它们在 IBC 的侵袭性中起着关键作用。IBC 的一个重要方面是激素受体(如雌激素和孕激素受体)的频繁表达丧失,这一现象仍在积极研究中。此外,IBC 病例中 ERBB2/HER2 和 TP53 的过度表达也是一个持续争论的话题,有研究表明,与非炎症性乳腺癌相比,IBC 中 ERBB2/HER2 和 TP53 的表达率更高。本综述旨在全面介绍 IBC 的组织病理学特征和诊断方法,强调需要进一步研究的关键领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inflammatory breast cancer: An overview about the histo-pathological aspect and diagnosis.

Inflammatory Breast Cancer (IBC) is a rare and aggressive form of locally advanced breast cancer, classified as stage T4d according to the tumor-node-metastasis staging criteria. This subtype of breast cancer is known for its rapid progression and significantly lower survival rates compared to other forms of breast cancer. Despite its distinctive clinical features outlined by the World Health Organization, the histopathological characteristics of IBC remain not fully elucidated, presenting challenges in its diagnosis and treatment. Histologically, IBC tumors often exhibit a ductal phenotype, characterized by emboli composed of pleomorphic cells with a high nuclear grade. These emboli are predominantly found in the papillary and reticular dermis of the skin overlaying the breast, suggesting a primary involvement of the lymphatic vessels. The tumor microenvironment in IBC is a complex network involving various cells such as macrophages, monocytes, and predominantly T CD8+ lymphocytes, and elements including blood vessels and extracellular matrix molecules, which play a pivotal role in the aggressive nature of IBC. A significant aspect of IBC is the frequent loss of expression of hormone receptors like estrogen and progesterone receptors, a phenomenon that is still under active investigation. Moreover, the overexpression of ERBB2/HER2 and TP53 in IBC cases is a topic of ongoing debate, with studies indicating a higher prevalence in IBC compared to non-inflammatory breast cancer. This overview seeks to provide a comprehensive understanding of the histopathological features and diagnostic approaches to IBC, emphasizing the critical areas that require further research.

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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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