International review of cell and molecular biology最新文献

DOGMA-seq and multimodal, single-cell analysis in acute myeloid leukemia.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-07 DOI: 10.1016/bs.ircmb.2024.08.001

JangKeun Kim, Nathan Schanzer, Ruth Subhash Singh, Mohammed I Zaman, J Sebastian Garcia-Medina, Jacqueline Proszynski, Saravanan Ganesan, Dan Landau, Christopher Y Park, Ari M Melnick, Christopher E Mason

{"title":"DOGMA-seq and multimodal, single-cell analysis in acute myeloid leukemia.","authors":"JangKeun Kim, Nathan Schanzer, Ruth Subhash Singh, Mohammed I Zaman, J Sebastian Garcia-Medina, Jacqueline Proszynski, Saravanan Ganesan, Dan Landau, Christopher Y Park, Ari M Melnick, Christopher E Mason","doi":"10.1016/bs.ircmb.2024.08.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.08.001","url":null,"abstract":"Acute myeloid leukemia (AML) is a complex cancer, yet advances in recent years from integrated genomics methods have helped improve diagnosis, treatment, and means of patient stratification. A recent example of a powerful, multimodal method is DOGMA-seq, which can measure chromatin accessibility, gene expression, and cell-surface protein levels from the same individual cell simultaneously. Previous bimodal single-cell techniques, such as CITE-seq (Cellular indexing of transcriptomes and epitopes), have only permitted the transcriptome and cell-surface protein expression measurement. DOGMA-seq, however, builds on this foundation and has implications for examining epigenomic, transcriptomic, and proteomic interactions between various cell types. This technique has the potential to be particularly useful in the study of cancers such as AML. This is because the cellular mechanisms that drive AML are rather heterogeneous and require a more complete understanding of the interplay between the genetic mutations, disruptions in RNA transcription and translation, and surface protein expression that cause these cancers to develop and evolve. This technique will hopefully contribute to a more clear and complete understanding of the growth and progression of complex cancers.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"67-108"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Epigenetic modulation of doxorubicin resistance and strategies for enhancing chemotherapeutic sensitivity.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-07 DOI: 10.1016/bs.ircmb.2024.09.004

Sruthi Sritharan, Nageswaran Sivalingam

引用次数: 0

Circulating biomarkers for diagnosis, prognosis, and treatment response prediction in cancer.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 DOI: 10.1016/S1937-6448(25)00031-0

Lorenzo Galluzzi, Sheila Spada

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Revisiting epigenetic regulation in cancer: Evolving trends and translational implications.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-04 DOI: 10.1016/bs.ircmb.2024.09.002

Mohammad Afsar Khan, Dhruv Mishra, Ranjan Kumar, Hifzur R Siddique

{"title":"Revisiting epigenetic regulation in cancer: Evolving trends and translational implications.","authors":"Mohammad Afsar Khan, Dhruv Mishra, Ranjan Kumar, Hifzur R Siddique","doi":"10.1016/bs.ircmb.2024.09.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.09.002","url":null,"abstract":"Cancer is a leading cause of mortality worldwide. The evolving role of epigenetics and tumor microenvironments of cancer pose significant challenges to the management of cancer. Besides genetics, epigenetic changes play a crucial role in the alteration of cellular machinery, progression, metastasis, epithelial-mesenchymal transition, and chemoresistance. Epigenetic changes such as DNA and RNA methylation, histone modifications, and chromatin modeling directly or indirectly influence the different stages of cancer from initiation to chemoresistant phenotype. In addition, alterations in the epigenetic machinery, such as hypo- or hyperactivation of proteins involved in epigenetic modifications, can lead to different health complications, including cancer. Recently, epi-drugs or epigenetic drugs offer emerging hope for the treatment and management of this deadly disease. Various epigenetic drugs targeting factors responsible for epigenetic modifications in cancer are currently under clinical trials. This chapter provides an overview of epigenetic modifications, their clinical implications, and the potential of epigenetic drugs for cancer treatment.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"1-24"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Epigenetic alteration in cervical cancer induced by human papillomavirus.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-04 DOI: 10.1016/bs.ircmb.2024.09.001

Elisa-Elvira Figueroa-Angulo, Jonathan Puente-Rivera, Yussel Fernando Perez-Navarro, Edgar Mendieta Condado, María-Elizbeth Álvarez-Sánchez

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Identification of circulating tumor DNA as a biomarker for diagnosis and response to therapies in cancer patients.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-07 DOI: 10.1016/bs.ircmb.2024.08.006

Ronan W Hsieh, Lynn K Symonds, Jason Siu, Stacey A Cohen

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Circulating biomarkers for diagnosis and response to therapies in cancer patients.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI: 10.1016/bs.ircmb.2024.08.007

Natália Marcéli Stefanes, Maria Eduarda Cunha-Silva, Lisandra de Oliveira Silva, Laura Otto Walter, Maria Cláudia Santos-Silva, Manas Ranjan Gartia

{"title":"Circulating biomarkers for diagnosis and response to therapies in cancer patients.","authors":"Natália Marcéli Stefanes, Maria Eduarda Cunha-Silva, Lisandra de Oliveira Silva, Laura Otto Walter, Maria Cláudia Santos-Silva, Manas Ranjan Gartia","doi":"10.1016/bs.ircmb.2024.08.007","DOIUrl":"10.1016/bs.ircmb.2024.08.007","url":null,"abstract":"Cancer presents a significant challenge to global health, driving worldwide concerted efforts to advance early detection, predict therapeutic response, and identify novel targeted therapies. Liquid biopsies emerge as promising avenues for discerning cancer biomarkers, offering less invasive approaches compared to conventional methods. Utilizing increasingly robust technologies, diverse bodily fluids can unveil genetic variants, epigenetic modifications, transcriptional alterations, and metabolomic signatures associated with cancer, thereby furnishing valuable insights for clinical management. This chapter intends to review the sources of cancer-related biomarkers found in circulation, prevalent techniques utilized for their identification, and the potential implications of different biomarker types on the management of cancer. Certain biomarkers currently used in clinical practice will be addressed, as well as potential biomarkers still in the study phase, and the inherent challenges in their practical implementation.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"391 ","pages":"1-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation of cancer.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 DOI: 10.1016/S1937-6448(25)00015-2

Lorenzo Galluzzi, Sheila Spada

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The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-02 DOI: 10.1016/bs.ircmb.2024.09.003

Priya Mondal, Gowthami Jayaprakash, Syed Musthapa Meeran

{"title":"The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer.","authors":"Priya Mondal, Gowthami Jayaprakash, Syed Musthapa Meeran","doi":"10.1016/bs.ircmb.2024.09.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.09.003","url":null,"abstract":"In preclinical studies, bioactive phytochemicals have shown enormous potential therapeutic efficacy against various human malignancies. These natural compounds have been shown to possess an inherent potential to alter the molecular signaling pathways and epigenetic modulatory activity involved in multiple physiological functions. Recently, epigenetic therapy has emerged as an important therapeutic modality due to the reversible nature of epigenetic alterations. To date, epigenetic modulatory compounds, for example, DNA methyltransferase inhibitors 5-azacytidine and 5'-deoxyazacytidine, as well as histone deacetylase inhibitors Vorinostat, Romidepsin, and Belinostat (PXD101), have been clinically approved by the FDA for the treatment of patients of leukemia and myelodysplastic syndrome. However, these synthetic epigenetic inhibitors are not as effective against many of the solid tumors. Therefore, the epigenetic modulatory phytochemicals provide new hope for improving the treatment modality as neoadjuvant and adjuvant therapy. It has been established that targeting more than one protein in the transformed cells simultaneously, that is, the multi-targeted therapeutic approach, might invoke a better therapeutic response. Therefore, here, we are compiling diverse evidences of the translational potential of novel combinatorial approaches utilizing the epigenetic modulatory phytochemicals with available therapeutics in the course of cancer treatment.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"140-185"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Nectin-4: A promising prognostic marker and therapeutic target in cancer.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-12 DOI: 10.1016/bs.ircmb.2024.08.004

Shilpa Kuttikrishnan, Kirti S Prabhu, Ummu Habeeba, Zahwa Mariyam, Queenie Fernandes, Mohsin Maqbool, Omar M Khan, Ajaz A Bhat, Shahab Uddin

{"title":"Nectin-4: A promising prognostic marker and therapeutic target in cancer.","authors":"Shilpa Kuttikrishnan, Kirti S Prabhu, Ummu Habeeba, Zahwa Mariyam, Queenie Fernandes, Mohsin Maqbool, Omar M Khan, Ajaz A Bhat, Shahab Uddin","doi":"10.1016/bs.ircmb.2024.08.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.08.004","url":null,"abstract":"Nectin cell adhesion protein 4 (Nectin-4), a calcium-independent immunoglobulin-like protein, has garnered significant attention in oncology due to its pronounced overexpression in malignant tumors and absence in healthy adult tissues. Elevated levels of Nectin-4 have been implicated in the pathogenesis of various cancers, including lung, breast, and urothelial carcinomas. Notably, Nectin-4 has emerged as a promising serological marker for these malignancies, facilitating early diagnosis and monitoring of disease progression. The clinical relevance of Nectin-4 is underscored by the Food and Drug Administration's approval of enfortumab vedotin (EV), the first antibody-drug conjugate targeting this protein, for the treatment of urothelial carcinoma. Ongoing clinical trials are expanding the therapeutic applications of EV, highlighting the critical role of Nectin-4 in targeted cancer therapy. Furthermore, novel therapeutic agents targeting Nectin-4 are under investigation, offering potential new avenues for cancer treatment. Despite these advancements, the precise molecular mechanisms by which Nectin-4 influences carcinogenesis and tumor progression remain inadequately understood. Challenges such as therapy-related adverse effects and the development of drug resistance further complicate the clinical management of Nectin-4-associated cancers. This review investigates the molecular functions of Nectin-4, emphasizing its diagnostic and prognostic value in cancer. We also explore the landscape of novel drug discoveries targeting Nectin-4 and provide an overview of current clinical trials aimed at utilizing this marker for therapeutic interventions. By elucidating the multifaceted role of Nectin-4 in malignancies, this article aims to advance our understanding and improve the clinical outcomes for patients with Nectin-4 overexpressing tumors.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"391 ","pages":"223-255"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0