International review of cell and molecular biology最新文献

DOGMA-seq and multimodal, single-cell analysis in acute myeloid leukemia.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-07 DOI: 10.1016/bs.ircmb.2024.08.001

JangKeun Kim, Nathan Schanzer, Ruth Subhash Singh, Mohammed I Zaman, J Sebastian Garcia-Medina, Jacqueline Proszynski, Saravanan Ganesan, Dan Landau, Christopher Y Park, Ari M Melnick, Christopher E Mason

{"title":"DOGMA-seq and multimodal, single-cell analysis in acute myeloid leukemia.","authors":"JangKeun Kim, Nathan Schanzer, Ruth Subhash Singh, Mohammed I Zaman, J Sebastian Garcia-Medina, Jacqueline Proszynski, Saravanan Ganesan, Dan Landau, Christopher Y Park, Ari M Melnick, Christopher E Mason","doi":"10.1016/bs.ircmb.2024.08.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.08.001","url":null,"abstract":"Acute myeloid leukemia (AML) is a complex cancer, yet advances in recent years from integrated genomics methods have helped improve diagnosis, treatment, and means of patient stratification. A recent example of a powerful, multimodal method is DOGMA-seq, which can measure chromatin accessibility, gene expression, and cell-surface protein levels from the same individual cell simultaneously. Previous bimodal single-cell techniques, such as CITE-seq (Cellular indexing of transcriptomes and epitopes), have only permitted the transcriptome and cell-surface protein expression measurement. DOGMA-seq, however, builds on this foundation and has implications for examining epigenomic, transcriptomic, and proteomic interactions between various cell types. This technique has the potential to be particularly useful in the study of cancers such as AML. This is because the cellular mechanisms that drive AML are rather heterogeneous and require a more complete understanding of the interplay between the genetic mutations, disruptions in RNA transcription and translation, and surface protein expression that cause these cancers to develop and evolve. This technique will hopefully contribute to a more clear and complete understanding of the growth and progression of complex cancers.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"67-108"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Epigenetic modulation of doxorubicin resistance and strategies for enhancing chemotherapeutic sensitivity.

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International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-07 DOI: 10.1016/bs.ircmb.2024.09.004

Sruthi Sritharan, Nageswaran Sivalingam

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Revisiting epigenetic regulation in cancer: Evolving trends and translational implications.

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International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-04 DOI: 10.1016/bs.ircmb.2024.09.002

Mohammad Afsar Khan, Dhruv Mishra, Ranjan Kumar, Hifzur R Siddique

{"title":"Revisiting epigenetic regulation in cancer: Evolving trends and translational implications.","authors":"Mohammad Afsar Khan, Dhruv Mishra, Ranjan Kumar, Hifzur R Siddique","doi":"10.1016/bs.ircmb.2024.09.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.09.002","url":null,"abstract":"Cancer is a leading cause of mortality worldwide. The evolving role of epigenetics and tumor microenvironments of cancer pose significant challenges to the management of cancer. Besides genetics, epigenetic changes play a crucial role in the alteration of cellular machinery, progression, metastasis, epithelial-mesenchymal transition, and chemoresistance. Epigenetic changes such as DNA and RNA methylation, histone modifications, and chromatin modeling directly or indirectly influence the different stages of cancer from initiation to chemoresistant phenotype. In addition, alterations in the epigenetic machinery, such as hypo- or hyperactivation of proteins involved in epigenetic modifications, can lead to different health complications, including cancer. Recently, epi-drugs or epigenetic drugs offer emerging hope for the treatment and management of this deadly disease. Various epigenetic drugs targeting factors responsible for epigenetic modifications in cancer are currently under clinical trials. This chapter provides an overview of epigenetic modifications, their clinical implications, and the potential of epigenetic drugs for cancer treatment.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"1-24"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Epigenetic alteration in cervical cancer induced by human papillomavirus.

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International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-04 DOI: 10.1016/bs.ircmb.2024.09.001

Elisa-Elvira Figueroa-Angulo, Jonathan Puente-Rivera, Yussel Fernando Perez-Navarro, Edgar Mendieta Condado, María-Elizbeth Álvarez-Sánchez

引用次数: 0

Epigenetic regulation of cancer.

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International review of cell and molecular biology Pub Date : 2025-01-01 DOI: 10.1016/S1937-6448(25)00015-2

Lorenzo Galluzzi, Sheila Spada

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The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer.

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International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-02 DOI: 10.1016/bs.ircmb.2024.09.003

Priya Mondal, Gowthami Jayaprakash, Syed Musthapa Meeran

{"title":"The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer.","authors":"Priya Mondal, Gowthami Jayaprakash, Syed Musthapa Meeran","doi":"10.1016/bs.ircmb.2024.09.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.09.003","url":null,"abstract":"In preclinical studies, bioactive phytochemicals have shown enormous potential therapeutic efficacy against various human malignancies. These natural compounds have been shown to possess an inherent potential to alter the molecular signaling pathways and epigenetic modulatory activity involved in multiple physiological functions. Recently, epigenetic therapy has emerged as an important therapeutic modality due to the reversible nature of epigenetic alterations. To date, epigenetic modulatory compounds, for example, DNA methyltransferase inhibitors 5-azacytidine and 5'-deoxyazacytidine, as well as histone deacetylase inhibitors Vorinostat, Romidepsin, and Belinostat (PXD101), have been clinically approved by the FDA for the treatment of patients of leukemia and myelodysplastic syndrome. However, these synthetic epigenetic inhibitors are not as effective against many of the solid tumors. Therefore, the epigenetic modulatory phytochemicals provide new hope for improving the treatment modality as neoadjuvant and adjuvant therapy. It has been established that targeting more than one protein in the transformed cells simultaneously, that is, the multi-targeted therapeutic approach, might invoke a better therapeutic response. Therefore, here, we are compiling diverse evidences of the translational potential of novel combinatorial approaches utilizing the epigenetic modulatory phytochemicals with available therapeutics in the course of cancer treatment.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"140-185"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Role of miRNAs as epigenetic regulators of immune checkpoints in lung cancer immunity.

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International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI: 10.1016/bs.ircmb.2024.08.002

Irene Cánovas-Cervera, Elena Nacher-Sendra, Guillermo Suay, Agustin Lahoz, José Luis García-Giménez, Salvador Mena-Mollá

{"title":"Role of miRNAs as epigenetic regulators of immune checkpoints in lung cancer immunity.","authors":"Irene Cánovas-Cervera, Elena Nacher-Sendra, Guillermo Suay, Agustin Lahoz, José Luis García-Giménez, Salvador Mena-Mollá","doi":"10.1016/bs.ircmb.2024.08.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.08.002","url":null,"abstract":"The advent of immunotherapy in cancer has provided new avenues in the treatment of many malignancies at various stages. Specifically, immune checkpoint inhibitors (ICIs) have transformed the field of lung cancer treatment. However, since some tumors can evade the immune system, not all patients respond properly. Recent research has provided evidence showing how microRNAs (miRNAs) are involved in regulating many immune checkpoints. MiRNAs have demonstrated their ability to modulate immune evasion of tumor cells. Currently, reliable markers are being sought to predict the efficacy of immunotherapy in these types of cancers. Therefore, the association of serum miRNAs and the response of ICIs in lung cancer is under study. Many miRNA molecules and their corresponding target genes have been identified in the regulation of chemoresistance. Therefore, elucidating how these miRNAs control the function of immune checkpoints, as well as the effectiveness of therapies based on ICIs set the basis for the development of new biomarkers to predict treatment response to ICIs. This chapter delves into the molecular role of miRNAs interacting with ICs, such as PD-1 and PD-L1, and the clinical utility of miRNAs, such as miR-16, miR-146a, and miR-335, in predicting treatment response to ICI-based therapy in lung cancer. The aim is to provide a deep insight of the current landscape, serving as a cornerstone for further research.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"109-139"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Role of chemokine receptors in transplant rejection and graft-versus-host disease. 趋化因子受体在移植排斥反应和移植物抗宿主疾病中的作用。

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International review of cell and molecular biology Pub Date : 2024-08-15 DOI: 10.1016/bs.ircmb.2024.07.004

Paula Alonso-Guallart,David Harle

{"title":"Role of chemokine receptors in transplant rejection and graft-versus-host disease.","authors":"Paula Alonso-Guallart,David Harle","doi":"10.1016/bs.ircmb.2024.07.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.07.004","url":null,"abstract":"Organ transplantation increases life expectancy and improves the quality of life of patients experiencing specific conditions such as terminal organ failure. Despite matching efforts between donor and recipient, immune activation can interfere with allograft survival after transplantation if immunosuppression is not used. With both innate and adaptive responses, this is a complicated immunological process. This can lead to organ rejection, or graft-versus-host disease (GVHD), depending on the origin of the immune response. Inflammatory factors, such as chemokine receptors and their ligands, are involved in a wide variety of immunological processes, including modulating transplant rejection or GVHD, therefore, chemokine biology has been a major focus of transplantation studies. These molecules attract circulating peripheral leukocytes to infiltrate into the allograft and facilitate dendritic and T cell trafficking between lymph nodes and the graft during the allogeneic response. In this chapter, we will review the most relevant chemokine receptors such as CXCR3 and CCR5, among others, and their ligands involved in the process of allograft rejection for solid organ transplantation and graft-versus-host disease in the context of hematopoietic cell transplantation.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"8 1","pages":"95-123"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Chemokine receptors and their ligands in breast cancer: The key roles in progression and metastasis. 乳腺癌中的趋化因子受体及其配体：乳腺癌进展和转移中的关键作用。

3区生物学

International review of cell and molecular biology Pub Date : 2024-08-05 DOI: 10.1016/bs.ircmb.2024.07.002

Julio Valdivia-Silva,Alberto Chinney-Herrera

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Role of chemokine receptors in gastrointestinal mucosa. 趋化因子受体在胃肠粘膜中的作用。

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International review of cell and molecular biology Pub Date : 2024-05-31 DOI: 10.1016/bs.ircmb.2024.02.003

Brett Bell,Kevin Flores-Lovon,Luis A Cueva-Chicaña,Rodney Macedo

{"title":"Role of chemokine receptors in gastrointestinal mucosa.","authors":"Brett Bell,Kevin Flores-Lovon,Luis A Cueva-Chicaña,Rodney Macedo","doi":"10.1016/bs.ircmb.2024.02.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.02.003","url":null,"abstract":"Chemokine receptors are essential for the immune response in the oral and gut mucosa. The gastrointestinal mucosa is characterized by the presence of immune populations because it is susceptible to inflammatory and infectious diseases, necessitating immune surveillance. Chemokine receptors are expressed on immune cells and play a role in gastrointestinal tissue-homing, although other non-immune cells also express them for various biological functions. CCR9, CXCR3 and CXCR6 play an important role in the T cell response in inflammatory and neoplastic conditions of the gastrointestinal mucosa. However, CXCR6 could also be found in gastric cancer cells, highlighting the different roles of chemokine receptors in different pathologies. On the other hand, CCR4 and CCR8 are critical for Treg migration in gastrointestinal tissues, correlating with poor prognosis in mucosal cancers. Other chemokine receptors are also important in promoting myeloid infiltration with context-dependent roles. Further, CXCR4 and CXCR7 are also present in gastrointestinal tumor cells and are known to stimulate proliferation, migration, and invasion into other tissues, among other pro-tumorigenic functions. Determining the processes underlying mucosal immunity and creating tailored therapeutic approaches for gastrointestinal diseases requires an understanding of the complex interactions that occur between chemokine receptors and their ligands in these mucosal tissues.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"8 1","pages":"20-52"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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