International review of cell and molecular biology最新文献

Autophagy in adipose tissue thermogenic function. 脂肪组织产热功能中的自噬。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-11-14 DOI: 10.1016/bs.ircmb.2025.10.006

Joan Villarroya, Albert Blasco-Roset, Marta Giralt

{"title":"Autophagy in adipose tissue thermogenic function.","authors":"Joan Villarroya, Albert Blasco-Roset, Marta Giralt","doi":"10.1016/bs.ircmb.2025.10.006","DOIUrl":"10.1016/bs.ircmb.2025.10.006","url":null,"abstract":"Brown adipose tissue (BAT) is the main site of adaptive thermogenesis, a heat-producing process essential for maintaining body temperature, especially in cold environments. While abundant in newborns, BAT is also present in adults, where it becomes activated under specific stimuli such as cold exposure or food intake. In addition, white adipose tissue (WAT) can undergo a \"browning\" process, generating beige adipocytes with thermogenic properties similar to classical brown adipocytes. BAT is highly innervated and vascularized, features that support its thermogenic function by facilitating sympathetic nervous system activation and efficient heat distribution. BAT activation increases energy expenditure and plays a protective role against obesity and metabolic disorders. A growing body of evidence highlights autophagy as a critical regulator of BAT and beige adipocyte function. During thermogenic activation, autophagy, especially mitophagy, is suppressed, promoting mitochondrial accumulation and heat production. Conversely, enhanced autophagy contributes to BAT whitening and functional decline, as seen in obesity and aging. Although the role of autophagy in thermogenesis remains unclear, modulating autophagic pathways represents a promising strategy to boost thermogenic activity and improve metabolic health. Understanding the molecular mechanisms underlying BAT plasticity and autophagic regulation could offer novel therapeutic avenues for combating obesity and related metabolic diseases.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"404 ","pages":"197-231"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-23 blockade: A strategy for managing pain-related inflammatory diseases. IL-23阻断：一种治疗疼痛相关炎症性疾病的策略

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2026-02-24 DOI: 10.1016/bs.ircmb.2026.02.005

Mario García-Domínguez

引用次数: 0

Epigenetic regulation via histone modifications in ovarian cancer. 组蛋白修饰在卵巢癌中的表观遗传调控。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-10-10 DOI: 10.1016/bs.ircmb.2025.08.003

Junzui Li, Hao Huang

{"title":"Epigenetic regulation via histone modifications in ovarian cancer.","authors":"Junzui Li, Hao Huang","doi":"10.1016/bs.ircmb.2025.08.003","DOIUrl":"10.1016/bs.ircmb.2025.08.003","url":null,"abstract":"Ovarian cancer is a highly heterogeneous and lethal gynecological malignancy, with its progression tightly regulated by both genetic and epigenetic mechanisms. Among the epigenetic regulators, histone modifications-including acetylation, methylation, phosphorylation, ubiquitination, and SUMOylation-have emerged as pivotal modulators of chromatin architecture and gene transcription. These post-translational modifications, governed by specific histone-modifying enzymes, shape the transcriptional landscape of tumor cells and influence key oncogenic processes such as cellular proliferation, invasion, stemness, DNA repair, and chemotherapy resistance. Dysregulation of enzymes such as histone acetyltransferases (HATs), deacetylases (HDACs), methyltransferases (HMTs), demethylases (HDMs), ubiquitin ligases, and SUMO ligases has been implicated in the pathogenesis of ovarian cancer and is associated with adverse clinical outcomes. Importantly, these modifications are reversible, rendering them tractable therapeutic targets. This review provides a comprehensive synthesis of the major classes of histone modifications and their biological functions in ovarian cancer, highlights recent insights into the interplay between different modifications (crosstalk), and evaluates ongoing therapeutic strategies that aim to reverse epigenetic dysregulation. By elucidating the complex epigenetic landscape, this review supports the development of next-generation diagnostic, prognostic, and therapeutic approaches in ovarian cancer.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"400 ","pages":"107-134"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147573780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating biomarkers: Facilitating the diagnosis and treatment of cancer and other chronic diseases. 循环生物标志物：促进癌症和其他慢性疾病的诊断和治疗。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-06-24 DOI: 10.1016/bs.ircmb.2025.05.001

Hongsheng Ji, Tingtao Ye, Xiaorui Nie, Yuming Chen, Huiqin Li, Silu Chen, Yanping Xiao, Ming Shao, Tao Wang, Rui Zheng, Mulong Du

引用次数: 0

Advances in nano biomaterials for biomedical engineering. 应用于生物医学工程的纳米生物材料研究进展。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2026-05-18 DOI: 10.1016/bs.ircmb.2026.04.001

Poojan Chaniyara, Mohnish Gandhi, Dhruvesh Maiya, Tvarit Patel

{"title":"Advances in nano biomaterials for biomedical engineering.","authors":"Poojan Chaniyara, Mohnish Gandhi, Dhruvesh Maiya, Tvarit Patel","doi":"10.1016/bs.ircmb.2026.04.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2026.04.001","url":null,"abstract":"Systemic toxicity and off target effects are some of the major drawbacks of traditional, broad-spectrum therapies. Nanotechnology effectively counters these by offering precise, targeted alternatives and hence, reshaping biomedical engineering, therapeutics, diagnostics and even tissue regeneration. We explore six key nano-biomaterial platforms that exemplify this technological revolution. Silk fibroin nano-patches with engineered exosomes help diabetic wounds heal by producing collagen. Hydrogel activated with nanoparticle form nanoadhesives that bond well with wet environments, such as surgical sites. Graphene-based neural interfaces are characterized by high electrical conductivity with low immunogenicity. Bioelectronic-hydrogel composites adapt tissue mechanics for better physiological sensing. The pH-responsive metal-organic frameworks show remarkable potential in cancer treatment enabling targeted drug delivery, reducing harm to surrounding healthy tissue, and magnetic nanoparticles coated in cancer cell membranes improve natural killer-cell therapies. Despite these remarkable advances, the challenge of transition from laboratories to clinics faces many hurdles. Demands for scalable manufacturing techniques, strategies to suppress undesirable immune reactions and passing through safety and regulatory standards are some of the major challenges in Nanotechnology. Collaborative approaches from interdisciplinary fields like material science, biology, engineering and clinics may present a positive outlook to these issues. Nanotechnology can offer promising precision medicine tailored to an individual's safety and dosage profiles, minimising off target interaction risks.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"405 ","pages":"47-110"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurodiagnostic: Advances in diagnostic tools. 神经诊断：诊断工具的进展。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-12-19 DOI: 10.1016/bs.ircmb.2025.12.001

Shreya Dave, Juni Banerjee, Shuvomoy Banerjee, Anand Krishna Tiwari

{"title":"Neurodiagnostic: Advances in diagnostic tools.","authors":"Shreya Dave, Juni Banerjee, Shuvomoy Banerjee, Anand Krishna Tiwari","doi":"10.1016/bs.ircmb.2025.12.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2025.12.001","url":null,"abstract":"Understanding the pathologies related to neurological issues, viz. Alzheimer's disease (AD), brain tumors, and multiple sclerosis (MS) are complex and still lack effective therapeutics. Management of the global health burden caused by the escalating cases of neurodegenerative diseases urgently requires early and precise diagnosis. While conventional diagnostic tools like X-ray, Computed Tomography (CT), and Electrophysiological Techniques still hold a crucial role in the field of neurodiagnosis, researchers and clinicians are searching for advancements and the development of cutting-edge tools to enhance diagnostic accuracy, early detection, and improved health outcomes. Some later developed tools like PET and fMRI have proven beneficial in diagnosing the structural and functional aspects of neurological pathologies. However, specific and differential diagnosis for different neurodegenerative diseases is critical. We discuss how Omics studies (including proteomics and genomics), Artificial Intelligence (AI), and Machine learning (ML) have further enhanced the advancements in the field of neurodiagnostics. Our chapter highlights the importance of identifying novel blood-based, cerebrospinal fluid (CSF) based biomarkers while giving emphasis to developing non-invasive biomarkers to uplift the field of neurodiagnosis. The chapter concludes that the importance of the development of advanced bioimaging, multi-omics studies, computational studies, and exploring futuristic technologies, including the development of biosensors, can pave the path for next-generation neurodiagnostic techniques.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"405 ","pages":"111-147"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid biopsy approaches to capture minimal residual disease and therapy response in patients with early stage cancers. 液体活检方法捕获最小残留疾病和早期癌症患者的治疗反应。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2024-12-14 DOI: 10.1016/bs.ircmb.2024.12.002

Blair V Landon, Jinny Huang, Ellie G Evangelopoulou, Valsamo Anagnostou, Jenna V Canzoniero

引用次数: 0

Unraveling the interplay of glycolysis, lactylation, and autophagy. 揭示糖酵解、乳酸化和自噬的相互作用。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-09-09 DOI: 10.1016/bs.ircmb.2025.08.007

Marco Cordani, Federica Michetti, Raffaele Strippoli, Cristiano Rumio, Guillermo Velasco, Fabrizio Marcucci

{"title":"Unraveling the interplay of glycolysis, lactylation, and autophagy.","authors":"Marco Cordani, Federica Michetti, Raffaele Strippoli, Cristiano Rumio, Guillermo Velasco, Fabrizio Marcucci","doi":"10.1016/bs.ircmb.2025.08.007","DOIUrl":"10.1016/bs.ircmb.2025.08.007","url":null,"abstract":"Glycolysis and macroautophagy (hereafter autophagy) are fundamental biological processes involved in many physiological and pathological settings. Both have been shown to play pivotal roles in tumor initiation and progression. Metabolic reprogramming has been proposed as one of the hallmarks of cancer although in recent times the role of oxidative metabolism in tumorigenesis has been reevaluated and it seems more appropriate to talk about upregulated glycolytic or oxidative metabolism. Autophagy on the other hand, has been shown to play an antitumor role in initial stages of tumorigenesis, while having a tumor-promoting role in tumor progression. Glycolysis and autophagy have long been known to have a complex relationship with each other. In this article we give a picture of this relationship. We show that glycolysis can promote either upregulation or inhibition of autophagy. Vice versa, autophagy can also either promote upregulation or inhibition of glycolytic metabolism. These are highly contradictory effects that appear difficult to reconcile. We suggest that induction of glycolysis or autophagy in the presence of nutrient deprivation or nutrient sufficiency may be at the origin of at least part of these contradictory findings.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"403 ","pages":"29-63"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in protein engineering. 蛋白质工程进展。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2026-01-28 DOI: 10.1016/bs.ircmb.2025.11.002

Huong Lan Vuong, Hien Thi Thu Le

引用次数: 0

Autophagy and type 2 diabetes: Bridging the gap in metabolic health. 自噬和2型糖尿病：弥合代谢健康的差距。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-09-13 DOI: 10.1016/bs.ircmb.2025.08.006

Agustina Creus, Leonardo Ortega, David Sebastián

引用次数: 0