International review of cell and molecular biology最新文献

Circulating biomarkers: Facilitating the diagnosis and treatment of cancer and other chronic diseases. 循环生物标志物：促进癌症和其他慢性疾病的诊断和治疗。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-06-24 DOI: 10.1016/bs.ircmb.2025.05.001

Hongsheng Ji, Tingtao Ye, Xiaorui Nie, Yuming Chen, Huiqin Li, Silu Chen, Yanping Xiao, Ming Shao, Tao Wang, Rui Zheng, Mulong Du

引用次数: 0

Epigenetic regulation via histone modifications in ovarian cancer. 组蛋白修饰在卵巢癌中的表观遗传调控。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-10-10 DOI: 10.1016/bs.ircmb.2025.08.003

Junzui Li, Hao Huang

{"title":"Epigenetic regulation via histone modifications in ovarian cancer.","authors":"Junzui Li, Hao Huang","doi":"10.1016/bs.ircmb.2025.08.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2025.08.003","url":null,"abstract":"Ovarian cancer is a highly heterogeneous and lethal gynecological malignancy, with its progression tightly regulated by both genetic and epigenetic mechanisms. Among the epigenetic regulators, histone modifications-including acetylation, methylation, phosphorylation, ubiquitination, and SUMOylation-have emerged as pivotal modulators of chromatin architecture and gene transcription. These post-translational modifications, governed by specific histone-modifying enzymes, shape the transcriptional landscape of tumor cells and influence key oncogenic processes such as cellular proliferation, invasion, stemness, DNA repair, and chemotherapy resistance. Dysregulation of enzymes such as histone acetyltransferases (HATs), deacetylases (HDACs), methyltransferases (HMTs), demethylases (HDMs), ubiquitin ligases, and SUMO ligases has been implicated in the pathogenesis of ovarian cancer and is associated with adverse clinical outcomes. Importantly, these modifications are reversible, rendering them tractable therapeutic targets. This review provides a comprehensive synthesis of the major classes of histone modifications and their biological functions in ovarian cancer, highlights recent insights into the interplay between different modifications (crosstalk), and evaluates ongoing therapeutic strategies that aim to reverse epigenetic dysregulation. By elucidating the complex epigenetic landscape, this review supports the development of next-generation diagnostic, prognostic, and therapeutic approaches in ovarian cancer.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"400 ","pages":"107-134"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147573780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid biopsy approaches to capture minimal residual disease and therapy response in patients with early stage cancers. 液体活检方法捕获最小残留疾病和早期癌症患者的治疗反应。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2024-12-14 DOI: 10.1016/bs.ircmb.2024.12.002

Blair V Landon, Jinny Huang, Ellie G Evangelopoulou, Valsamo Anagnostou, Jenna V Canzoniero

引用次数: 0

The current findings and potential applications of breast cancer epigenetics. 乳腺癌表观遗传学的最新发现及潜在应用。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-10-25 DOI: 10.1016/bs.ircmb.2025.10.002

Yen-Vy Nguyen Thi, Quy Do Van, Hai Linh Duong Nguyen, Thanh Van Cao Thi, Dinh-Toi Chu

引用次数: 0

Epigenetic regulation of cancer. 癌症的表观遗传调控。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 DOI: 10.1016/S1937-6448(26)00028-6

Sheila Spada, Lorenzo Galluzzi

引用次数: 0

Application of bioinformatics and data science in studies of cancer epigenetics. 生物信息学与数据科学在癌症表观遗传学研究中的应用。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-10-30 DOI: 10.1016/bs.ircmb.2025.10.003

Dinh-Toi Chu, Trong-Duc Dao, Minh-Ha To, Tri Dung Trinh, Nhat-Le Bui

{"title":"Application of bioinformatics and data science in studies of cancer epigenetics.","authors":"Dinh-Toi Chu, Trong-Duc Dao, Minh-Ha To, Tri Dung Trinh, Nhat-Le Bui","doi":"10.1016/bs.ircmb.2025.10.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2025.10.003","url":null,"abstract":"The dysregulation at the epigenetic level, such as DNA methylation, histone modifications, and changes in noncoding RNA, plays an important role in many serious human pathologies, including cancers. Epigenetics modulates the expression of tumor-related genes without any changes in the DNA sequences, thus understanding the epigenetic profile is a promising way to clarify the underlying mechanism of cancers as well as other diseases. Specific techniques like chromatin immunoprecipitation followed by sequencing (ChIP-seq), whole-genome bisulfite sequencing (WGBS), or mass spectrometry (MS) were developed to obtain epigenetic data. This leads to the need for robust tools to analyze and interpret these high-throughput data. With the development of bioinformatics tools, several complex interactions between DNA methylation and chromatin modification were clarified to help researchers control gene expression. Moreover, data science, and information technology, especially machine learning and deep learning, have revolutionized the study of epigenetics in cancer, providing powerful tools to integrate both genetic and epigenetic data, as well as clinical/para-clinical characteristics to enhance the accuracy of cancer diagnosis and treatment strategies. In this study, we will provide an overview of epigenetics' role in cancer, and more importantly, an update on the application of bioinformatics and data science in the epigenetic field for cancers. Integrating epigenetic data with other data like omics and clinical data with the help of bioinformatics and data science is an emerging direction for deciphering the epigenetic landscape of cancer and identifying potential therapeutic targets.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"400 ","pages":"157-172"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic insights of microRNAs: Pioneering cancer detection via advanced biosensors. 微rna的表观遗传学见解：通过先进的生物传感器进行癌症检测的先驱。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-02-25 DOI: 10.1016/bs.ircmb.2025.01.008

P P Ashikha Shirin Usman, Durairaj Sekar

{"title":"Epigenetic insights of microRNAs: Pioneering cancer detection via advanced biosensors.","authors":"P P Ashikha Shirin Usman, Durairaj Sekar","doi":"10.1016/bs.ircmb.2025.01.008","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2025.01.008","url":null,"abstract":"The epigenetic landscape of cancer reveals how microRNAs (miRNAs) regulate gene expression through epigenetic mechanisms, alongside advancements in miRNA-based biosensor technology for early detection. Epigenetics, which studies heritable gene function changes without altering DNA sequences, has transformed our understanding of cancer by highlighting the complex interaction between genetics and environment. Key mechanisms such as DNA methylation, histone modification, and chromatin remodelling shape gene expression and cellular identity, with dysregulation in these processes often marking cancer development. Within this framework, miRNAs act as crucial epigenetic regulators, influencing gene expression post-transcriptionally and functioning as either oncogenes (oncomiRs) or tumour suppressors. miRNAs interact with epigenetic modifiers like histone deacetylases (HDACs) and DNA methyltransferases (DNMTs), creating regulatory networks that affect cancer cell behaviours such as proliferation, differentiation, and apoptosis. To apply these molecular insights, the chapter reviews innovations in miRNA-targeting biosensors. Electrochemical and photoelectrochemical biosensors, enhanced with nanotechnology, are designed to detect miRNAs at ultra-low concentrations in biological fluids, addressing limitations of conventional cancer diagnostics. These biosensors offer high sensitivity, specificity, and point-of-care potential, with benefits such as rapid response, cost-efficiency, and miniaturization. Case studies showcase miRNA-based biosensors targeting cancer-related miRNAs, underscoring their promise in early cancer detection and monitoring. By bridging epigenetics, miRNA regulation, and biosensor technology, these emerging diagnostic tools offer new possibilities for improving cancer diagnosis and patient outcomes.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"400 ","pages":"31-62"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemicals with epigenetic properties and their role in melanoma therapy. 具有表观遗传特性的植物化学物质及其在黑色素瘤治疗中的作用。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2024-12-07 DOI: 10.1016/bs.ircmb.2024.12.001

Ioannis Anestopoulos, Sotiris Kyriakou, Maria V Deligiorgi, Dimitrios T Trafalis, Sotiris Botaitis, Alexandra N Giatromanolaki, Rodrigo Franco, Michael I Koukourakis, Aglaia Pappa, Mihalis I Panayiotidis

{"title":"Phytochemicals with epigenetic properties and their role in melanoma therapy.","authors":"Ioannis Anestopoulos, Sotiris Kyriakou, Maria V Deligiorgi, Dimitrios T Trafalis, Sotiris Botaitis, Alexandra N Giatromanolaki, Rodrigo Franco, Michael I Koukourakis, Aglaia Pappa, Mihalis I Panayiotidis","doi":"10.1016/bs.ircmb.2024.12.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.12.001","url":null,"abstract":"Malignant melanoma is the most aggressive and lethal type of skin cancer associated with increased mortality rates. Moreover, beyond the genetic background, the altered epigenetic landscape (e.g., abnormal patterns of DNA methylation, aberrant histone modifications and de-regulated expression levels of ncRNAs) further contributes to the pathophysiology of the disease. In addition, despite the improvement of current anti-melanoma strategies and the development of new therapeutic approaches, the 5-year survival among melanoma patients is still high, mainly due to acquired-drug resistance. On the other hand, phytochemicals have been associated with various health-promoting properties through pleiotropic mechanisms including acting as potent epigenetic regulators restoring back a normal phenotype in various experimental cancer models. In this review article, we discuss the general characteristics of malignant melanoma and current therapeutic approaches while we report the epigenetic basis of the disease along with the main compounds capable of restoring a normal epigenetic landscape. Finally, we describe the role of various phytochemicals in targeting the epigenome of malignant melanoma thereby potentially acting as an alternative therapeutic approach.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"400 ","pages":"1-30"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147573909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles as dynamic biomarkers: Monitoring therapeutic responses and drug resistance in cancer. 细胞外囊泡作为动态生物标志物：监测癌症的治疗反应和耐药性。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-02-28 DOI: 10.1016/bs.ircmb.2025.01.006

Shaimaa A Gouhar, Zakaria Y Abd Elmageed, Sherien M El-Daly

{"title":"Extracellular vesicles as dynamic biomarkers: Monitoring therapeutic responses and drug resistance in cancer.","authors":"Shaimaa A Gouhar, Zakaria Y Abd Elmageed, Sherien M El-Daly","doi":"10.1016/bs.ircmb.2025.01.006","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2025.01.006","url":null,"abstract":"Cancer remains a major health challenge, with traditional monitoring approaches that are often limited in sensitivity and invasiveness. Liquid biopsies, particularly those involving circulating extracellular vesicles (EVs), have emerged as a promising non-invasive approach that holds efficient diagnostic and prognostic value, predicting disease development and patient outcomes. Furthermore, EVs can monitor therapy responses and detect potential resistance development. In this review, we delineate the diverse cargo within EVs, including proteins, lipids, RNAs, and DNA, and their potential implications for cancer progression. The clinical utilization of EVs as prognostic and treatment-monitoring biomarkers for various types of cancer is addressed in depth, with a focus on their ability to identify molecular signatures associated with drug resistance. We also present a comprehensive collection of studies on EV-derived biomarkers for monitoring treatment responses across various cancer types, as well as investigations into EV-derived biomarkers associated with therapeutic resistance. While the promise of EV biomarkers in cancer therapy monitoring is acknowledged, we also discuss in detail the existing challenges and future directions in this research area. This review ultimately improves our understanding of liquid biopsies, specifically EV biomarkers, paving the way for more personalized and effective dynamic biomarkers.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"399 ","pages":"43-112"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating biomarkers for diagnosis, prognosis, and treatment response prediction in cancer. 用于癌症诊断、预后和治疗反应预测的循环生物标志物。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 DOI: 10.1016/S1937-6448(26)00017-1

Sheila Spada, Lorenzo Galluzzi

引用次数: 0