Revisiting epigenetic regulation in cancer: Evolving trends and translational implications.

3区生物学 Q1 Biochemistry, Genetics and Molecular Biology

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-04 DOI:10.1016/bs.ircmb.2024.09.002

Mohammad Afsar Khan, Dhruv Mishra, Ranjan Kumar, Hifzur R Siddique

{"title":"Revisiting epigenetic regulation in cancer: Evolving trends and translational implications.","authors":"Mohammad Afsar Khan, Dhruv Mishra, Ranjan Kumar, Hifzur R Siddique","doi":"10.1016/bs.ircmb.2024.09.002","DOIUrl":null,"url":null,"abstract":"<p><p>Cancer is a leading cause of mortality worldwide. The evolving role of epigenetics and tumor microenvironments of cancer pose significant challenges to the management of cancer. Besides genetics, epigenetic changes play a crucial role in the alteration of cellular machinery, progression, metastasis, epithelial-mesenchymal transition, and chemoresistance. Epigenetic changes such as DNA and RNA methylation, histone modifications, and chromatin modeling directly or indirectly influence the different stages of cancer from initiation to chemoresistant phenotype. In addition, alterations in the epigenetic machinery, such as hypo- or hyperactivation of proteins involved in epigenetic modifications, can lead to different health complications, including cancer. Recently, epi-drugs or epigenetic drugs offer emerging hope for the treatment and management of this deadly disease. Various epigenetic drugs targeting factors responsible for epigenetic modifications in cancer are currently under clinical trials. This chapter provides an overview of epigenetic modifications, their clinical implications, and the potential of epigenetic drugs for cancer treatment.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"1-24"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International review of cell and molecular biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/bs.ircmb.2024.09.002","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/4 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}

引用次数: 0

Abstract

Cancer is a leading cause of mortality worldwide. The evolving role of epigenetics and tumor microenvironments of cancer pose significant challenges to the management of cancer. Besides genetics, epigenetic changes play a crucial role in the alteration of cellular machinery, progression, metastasis, epithelial-mesenchymal transition, and chemoresistance. Epigenetic changes such as DNA and RNA methylation, histone modifications, and chromatin modeling directly or indirectly influence the different stages of cancer from initiation to chemoresistant phenotype. In addition, alterations in the epigenetic machinery, such as hypo- or hyperactivation of proteins involved in epigenetic modifications, can lead to different health complications, including cancer. Recently, epi-drugs or epigenetic drugs offer emerging hope for the treatment and management of this deadly disease. Various epigenetic drugs targeting factors responsible for epigenetic modifications in cancer are currently under clinical trials. This chapter provides an overview of epigenetic modifications, their clinical implications, and the potential of epigenetic drugs for cancer treatment.

查看原文本刊更多论文

回顾表观遗传调控在癌症：演变趋势和翻译意义。

癌症是世界范围内导致死亡的主要原因。癌症的表观遗传学和肿瘤微环境的不断发展对癌症的管理提出了重大挑战。除遗传学外，表观遗传学变化在细胞机制、进展、转移、上皮-间质转化和化疗耐药的改变中起着至关重要的作用。表观遗传变化，如DNA和RNA甲基化、组蛋白修饰和染色质建模，直接或间接影响癌症从起始到耐药表型的不同阶段。此外，表观遗传机制的改变，如参与表观遗传修饰的蛋白质的低激活或高激活，可导致不同的健康并发症，包括癌症。最近，表观药物或表观遗传药物为治疗和管理这种致命疾病提供了新的希望。各种针对癌症表观遗传修饰因子的表观遗传药物目前正在临床试验中。本章概述了表观遗传修饰，它们的临床意义，以及表观遗传药物治疗癌症的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY

CiteScore

7.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.