International review of cell and molecular biology最新文献_第2页

Non-rhythmic modulators of the circadian system: A new class of circadian modulators. 昼夜节律系统的非节律调制器：一类新的昼夜节律调制器。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-05-09 DOI: 10.1016/bs.ircmb.2024.04.003

Leonardo Vinícius Monteiro de Assis, Henrik Oster

{"title":"Non-rhythmic modulators of the circadian system: A new class of circadian modulators.","authors":"Leonardo Vinícius Monteiro de Assis, Henrik Oster","doi":"10.1016/bs.ircmb.2024.04.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.04.003","url":null,"abstract":"The temporal organization of biological processes is critical for an organism's fitness and survival. An internal circadian clock network coordinates the alignment between the external and internal milieus via an array of systemic factors carrying temporal information such as core body temperature, autonomic activity, hormonal secretion, and behavioral functions. Collectively, these so called zeitgebers are characterized by strong temporal variations (i.e., high amplitudes). At the same time, target tissues show time windows of highest and lowest sensitivity to specific zeitgebers and, in this way, tissues can further modulate the effect of zeitgeber input in a process known as circadian gating. Such interplay between systemic signals and local circadian gating, however, suggests an additional level of temporal control-the resetting of target tissue rhythms in response to altered levels of tonic (i.e., non-rhythmic) signals. The recently identified tuning of liver transcriptome rhythms by thyroid hormones (THs) is one example of such regulation. THs show low-amplitude rhythms in the serum levels that are easily disrupted by altered thyroid states. At the same time, circadian rhythms in TH target tissues, such as liver, are markedly affected by alterations in TH state. Temporal regulation of TH target genes in other tissues suggests similar effects across the body. This chapter describes the rationale, experimental evidence, and potential consequences of this new level of circadian regulators.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"393 ","pages":"141-162"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of circulating tumor DNA as a biomarker for diagnosis and response to therapies in cancer patients. 循环肿瘤DNA作为癌症患者诊断和治疗反应的生物标志物的鉴定。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-07 DOI: 10.1016/bs.ircmb.2024.08.006

Ronan W Hsieh, Lynn K Symonds, Jason Siu, Stacey A Cohen

引用次数: 0

CTCs and liquid biopsies in patients with colorectal cancer. 结直肠癌患者的CTCs和液体活检。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-30 DOI: 10.1016/bs.ircmb.2024.10.001

Areeb Lutfi, Maaz Khan Afghan, Pashtoon Murtaza Kasi

引用次数: 0

Circulating biomarkers for diagnosis and response to therapies in cancer patients. 循环生物标志物用于癌症患者的诊断和治疗反应。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI: 10.1016/bs.ircmb.2024.08.007

Natália Marcéli Stefanes, Maria Eduarda Cunha-Silva, Lisandra de Oliveira Silva, Laura Otto Walter, Maria Cláudia Santos-Silva, Manas Ranjan Gartia

{"title":"Circulating biomarkers for diagnosis and response to therapies in cancer patients.","authors":"Natália Marcéli Stefanes, Maria Eduarda Cunha-Silva, Lisandra de Oliveira Silva, Laura Otto Walter, Maria Cláudia Santos-Silva, Manas Ranjan Gartia","doi":"10.1016/bs.ircmb.2024.08.007","DOIUrl":"10.1016/bs.ircmb.2024.08.007","url":null,"abstract":"Cancer presents a significant challenge to global health, driving worldwide concerted efforts to advance early detection, predict therapeutic response, and identify novel targeted therapies. Liquid biopsies emerge as promising avenues for discerning cancer biomarkers, offering less invasive approaches compared to conventional methods. Utilizing increasingly robust technologies, diverse bodily fluids can unveil genetic variants, epigenetic modifications, transcriptional alterations, and metabolomic signatures associated with cancer, thereby furnishing valuable insights for clinical management. This chapter intends to review the sources of cancer-related biomarkers found in circulation, prevalent techniques utilized for their identification, and the potential implications of different biomarker types on the management of cancer. Certain biomarkers currently used in clinical practice will be addressed, as well as potential biomarkers still in the study phase, and the inherent challenges in their practical implementation.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"391 ","pages":"1-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian rhythms in muscle health and diseases. 肌肉健康和疾病的昼夜节律。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-11-12 DOI: 10.1016/bs.ircmb.2024.10.002

Jeffrey J Kelu

{"title":"Circadian rhythms in muscle health and diseases.","authors":"Jeffrey J Kelu","doi":"10.1016/bs.ircmb.2024.10.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.10.002","url":null,"abstract":"All major life forms from bacteria to humans have internal clocks that regulate essential biological processes in a roughly 24-h cycle. In mammals, the central clock in the suprachiasmatic nucleus (SCN) is historically considered the top of a hierarchical organisation that dominates subordinate clocks in peripheral tissues and dictates the circadian behaviours of an organism. Recent studies, however, underscore the importance of the local circadian oscillators, such as the skeletal muscle clock, in regulating local metabolism and physiology. Studies in animal models show that the muscle peripheral clock per se is required for the expression of genes involved in glucose, lipid, and amino acid metabolism. Disruption of the muscle clock leads to glucose intolerance, insulin resistance, and alterations in muscle size and force. This highlights the vital role of the muscle clock in controlling muscle physiology and metabolism. In humans, a perturbation in the muscle circadian rhythms is seen in metabolic disorders such as type 2 diabetes, and muscle diseases such as dystrophies. Disruption of muscle metabolism is also seen when the internal rhythms are misaligned with the external rhythms (circadian misalignments) as in shift work. Understanding the mechanisms by which the muscle clock regulates circadian functions may help the development of new strategies, such as chronotherapy, to potentially prevent or treat muscle pathologies and maintain muscle health.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"393 ","pages":"45-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging interactions between circadian rhythms and extracellular vesicles. 昼夜节律与细胞外囊泡之间的相互作用。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-11-23 DOI: 10.1016/bs.ircmb.2024.11.001

Jacob G Smith

{"title":"Emerging interactions between circadian rhythms and extracellular vesicles.","authors":"Jacob G Smith","doi":"10.1016/bs.ircmb.2024.11.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.11.001","url":null,"abstract":"Circadian rhythms are present across species, tuning internal processes to daily changes in the environment. Driven by genetically encoded circadian clocks present throughout the body, and modulated by external inputs, the circadian system is a key player in metabolic control. However, the molecular mediators underlying coordination between cells and tissues are not well known. Extracellular vesicles (EVs) have emerged over recent years as important players in cell-cell and organ-organ communication, however the influence of circadian rhythms on EVs is not yet understood. Research into this area is still scarce, yet already offers glimpses into the potential impact of circadian rhythms on EV biology. In this review, recent discoveries that reveal, directly or indirectly, a potential role for circadian rhythms in EV abundance, properties, cargo and signalling functions are first discussed. Next, the feedback of EV signalling on circadian clocks is considered. Last, unanswered questions regarding the interaction between circadian rhythms and EVs are examined alongside potential approaches to address them. Overall, the circadian impact on EV signalling is an exciting yet understudied aspect that warrants further investigation.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"393 ","pages":"73-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver as a nexus of daily metabolic cross talk. 肝脏作为日常代谢串扰的纽带。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-06-25 DOI: 10.1016/bs.ircmb.2024.06.001

Christopher Litwin, Kevin B Koronowski

{"title":"Liver as a nexus of daily metabolic cross talk.","authors":"Christopher Litwin, Kevin B Koronowski","doi":"10.1016/bs.ircmb.2024.06.001","DOIUrl":"10.1016/bs.ircmb.2024.06.001","url":null,"abstract":"Over the course of a day, the circadian clock promotes a homeostatic balance between energy intake and energy expenditure by aligning metabolism with nutrient availability. In mammals, this process is driven by central clocks in the brain that control feeding behavior, the peripheral nervous system, and humoral outputs, as well as by peripheral clocks in non-brain tissues that regulate gene expression locally. Circadian organization of metabolism is critical, as circadian disruption is associated with increased risk of metabolic disease. Emerging evidence shows that circadian metabolism hinges upon inter-organ cross talk involving the liver, a metabolic hub that integrates many facets of systemic energy homeostasis. Here, we review spatiotemporal interactions, mainly metabolite exchange, signaling factors, and hormonal control, between the liver and skeletal muscle, pancreas, gut, microbiome, and adipose tissue. Modern society presents the challenge of circadian disturbances from rotating shift work to social jet lag and 24/7 food availability. Thus, it is important to better understand the mechanisms by which the clock system controls metabolic homeostasis and work toward targeted therapies.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"393 ","pages":"95-139"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation of cancer. 癌症的表观遗传调控。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 DOI: 10.1016/S1937-6448(25)00015-2

Lorenzo Galluzzi, Sheila Spada

引用次数: 0

The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer. 表观遗传调节生物活性植物化学物质作为辅助治疗癌症的翻译潜力。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-02 DOI: 10.1016/bs.ircmb.2024.09.003

Priya Mondal, Gowthami Jayaprakash, Syed Musthapa Meeran

{"title":"The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer.","authors":"Priya Mondal, Gowthami Jayaprakash, Syed Musthapa Meeran","doi":"10.1016/bs.ircmb.2024.09.003","DOIUrl":"10.1016/bs.ircmb.2024.09.003","url":null,"abstract":"In preclinical studies, bioactive phytochemicals have shown enormous potential therapeutic efficacy against various human malignancies. These natural compounds have been shown to possess an inherent potential to alter the molecular signaling pathways and epigenetic modulatory activity involved in multiple physiological functions. Recently, epigenetic therapy has emerged as an important therapeutic modality due to the reversible nature of epigenetic alterations. To date, epigenetic modulatory compounds, for example, DNA methyltransferase inhibitors 5-azacytidine and 5'-deoxyazacytidine, as well as histone deacetylase inhibitors Vorinostat, Romidepsin, and Belinostat (PXD101), have been clinically approved by the FDA for the treatment of patients of leukemia and myelodysplastic syndrome. However, these synthetic epigenetic inhibitors are not as effective against many of the solid tumors. Therefore, the epigenetic modulatory phytochemicals provide new hope for improving the treatment modality as neoadjuvant and adjuvant therapy. It has been established that targeting more than one protein in the transformed cells simultaneously, that is, the multi-targeted therapeutic approach, might invoke a better therapeutic response. Therefore, here, we are compiling diverse evidences of the translational potential of novel combinatorial approaches utilizing the epigenetic modulatory phytochemicals with available therapeutics in the course of cancer treatment.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"140-185"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omic features and clustering phenotypes of circulating tumor cells associated with metastasis and clinical outcomes. 循环肿瘤细胞的多组学特征和聚类表型与转移和临床结果相关。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-05-02 DOI: 10.1016/bs.ircmb.2024.03.009

Anmol Singh, Huiping Liu, Lamiaa El-Shennawy

{"title":"Multi-omic features and clustering phenotypes of circulating tumor cells associated with metastasis and clinical outcomes.","authors":"Anmol Singh, Huiping Liu, Lamiaa El-Shennawy","doi":"10.1016/bs.ircmb.2024.03.009","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.03.009","url":null,"abstract":"Metastasis is a lethal disease of cancer, spreading from primary tumors to the bloodstream as circulating tumor cells (CTCs), which disseminate to distant organs at low efficiency for secondary tumor regeneration, thereby contributing to unfavorable patient outcomes. The detection of dynamic CTC alterations can be indicative of cancer progression (residual cancer, aggressiveness, therapy resistance) or regression (therapy response), serving as biomarkers for diagnoses and prognoses. CTC heterogeneity is impacted by both intrinsic oncogenic changes and extrinsic microenvironmental factors (e.g. the immune system and circadian rhythm), altering the genomic/genetic, epigenomic/epigenetic, proteomic, post-translational, and metabolomic landscapes. In addition to homeostatic dynamics, regenerative stemness, and metabolic plasticity, a newly discovered feature of CTCs that influences metastatic outcomes is its intercellular clustering. While the dogma suggests that CTCs play solo as single cells in the circulation, CTCs can orchestrate with other CTCs or white blood cells to form homotypic or heterotypic multi-cellular clusters, with 20-100 times enhanced metastatic potential than single CTCs. CTC clusters promote cell survival and stemness through DNA hypomethylation and signaling pathways activated by clustering-driving proteins (CD44, CD81, ICAM1, Podocalyxin, etc). Heterotypic CTC clusters may protect CTCs from immune cell attacks if not being cleared by cytotoxic immune cells. This chapter mainly focused on CTC biology related to multi-omic features and metastatic outcomes. We speculate that CTCs could guide therapeutic targeting and be targeted specifically by anti-CTC therapeutics to reduce or eliminate cancer and cancer metastasis.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"392 ","pages":"67-100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0