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International review of cell and molecular biology最新文献

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Circulating biomarkers for diagnosis, prognosis, and treatment response prediction in cancer. 用于癌症诊断、预后和治疗反应预测的循环生物标志物。
3区 生物学
International review of cell and molecular biology Pub Date : 2025-01-01 DOI: 10.1016/S1937-6448(25)00031-0
Lorenzo Galluzzi, Sheila Spada
{"title":"Circulating biomarkers for diagnosis, prognosis, and treatment response prediction in cancer.","authors":"Lorenzo Galluzzi, Sheila Spada","doi":"10.1016/S1937-6448(25)00031-0","DOIUrl":"https://doi.org/10.1016/S1937-6448(25)00031-0","url":null,"abstract":"","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"391 ","pages":"xiii-xvii"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic modulation of doxorubicin resistance and strategies for enhancing chemotherapeutic sensitivity. 阿霉素耐药的表观遗传调控及提高化疗敏感性的策略。
3区 生物学
International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-07 DOI: 10.1016/bs.ircmb.2024.09.004
Sruthi Sritharan, Nageswaran Sivalingam
{"title":"Epigenetic modulation of doxorubicin resistance and strategies for enhancing chemotherapeutic sensitivity.","authors":"Sruthi Sritharan, Nageswaran Sivalingam","doi":"10.1016/bs.ircmb.2024.09.004","DOIUrl":"10.1016/bs.ircmb.2024.09.004","url":null,"abstract":"<p><p>With the rising global cancer burden, the dependency on chemotherapy also rises along with the complication of chemoresistance development. Studies on multi-drug resistant proteins provide a wide range of regulators, although the exact mechanism is not yet clearly understood. Epigenetic modifications play a vital role in the regulation of cellular processes and also in determining the efficacy of cancer therapy by modulating resistance development and tumor progression. Of the various epigenetic modifications, histone acetylation/deacetylation and DNA methylation are currently given more focus in evaluating their role in resistance development to doxorubicin. This chapter highlights the various studies conducted on the regulation of doxorubicin (dox) resistance based on these epigenetic modifications and the clinical trials conducted in evaluating its effectiveness as a potential combinational therapy.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"186-198"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The multipotential effect of microbiome in lung cancer development and progression. 微生物组在肺癌发生发展中的多潜能作用。
3区 生物学
International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-20 DOI: 10.1016/bs.ircmb.2024.12.011
Nastaran Karimi, Angélica Baca De Anda, Rachel Yang, Emre Aksan, Maria T Grimaldo, Seyed Javad Moghaddam
{"title":"The multipotential effect of microbiome in lung cancer development and progression.","authors":"Nastaran Karimi, Angélica Baca De Anda, Rachel Yang, Emre Aksan, Maria T Grimaldo, Seyed Javad Moghaddam","doi":"10.1016/bs.ircmb.2024.12.011","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.12.011","url":null,"abstract":"<p><p>Lung cancer is the leading cause of cancer-related deaths worldwide. Despite the introduction of numerous drugs to cure this deadly disease, treatment outcomes differ significantly among patients. This differential response has drawn attention to individual patient characteristics, particularly the microbiome. In recent years, the microbiome has garnered significant interest from scientists in various fields including autoimmune, inflammatory, and cancer research. These studies have primarily focused on the composition and diversity of the gut microbiome, pointing out its fundamental effect on the development and progression of diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and lung cancer. Recent findings have also highlighted the impact of the gut microbiome on the efficacy of immunotherapy in lung cancer patients. In this chapter, we will delve into the multifaceted role of microbiome in lung cancer prevention, progression, and treatment outcome.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"394 ","pages":"171-196"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of microbial dysbiosis on autoimmune associated inflammation. 微生物生态失调对自身免疫性炎症的影响。
3区 生物学
International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-26 DOI: 10.1016/bs.ircmb.2024.12.016
Kamini Singh, Amarpal Singh Bhadauriya
{"title":"Effect of microbial dysbiosis on autoimmune associated inflammation.","authors":"Kamini Singh, Amarpal Singh Bhadauriya","doi":"10.1016/bs.ircmb.2024.12.016","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.12.016","url":null,"abstract":"<p><p>Trillions of microorganisms inhabit the human body, playing crucial roles in the development of the immune system, maintaining balance within the gut's immune system, and overall well-being. When these microbial communities experience imbalance, known as dysbiosis, it can lead to localized inflammatory conditions such as colitis and inflammatory bowel diseases, as well as systemic autoimmune disorders like type 1 diabetes, rheumatoid arthritis, and multiple sclerosis. Gut microbes engage with the immune system through various means, including influencing host microRNAs to regulate gene expression and generating metabolites that interact with cellular receptors such as TLRs and GPCRs. These interactions impact critical immune processes like the differentiation of lymphocytes, the production of interleukins, and the maintenance of gut barrier function. Looking into, how gut microbes contribute to or defend against systemic autoimmune diseases is crucial for developing strategies to manage or prevent these conditions. These approaches may include dietary or lifestyle modifications, microbiome-targeted therapies such as prebiotics or probiotics, the identification of diagnostic biomarkers for predicting disease risk, and monitoring and intervening in shifts in microbial populations during autoimmune flare-ups. Recognizing the microbiome's significance in systemic autoimmune diseases offers promise for transforming these presently challenging-to-treat conditions into more controllable or preventable ones.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"395 ","pages":"1-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of gut microbiota on systemic immune responses and cancer immunotherapy. 肠道菌群对全身免疫反应和癌症免疫治疗的影响。
3区 生物学
International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-22 DOI: 10.1016/bs.ircmb.2024.12.005
Swathi P Murakonda, Sahasra Balusu, Haritha Chava, Ajay B Murakonda, Reshmi Polneedi, Sushanth Bodduluri, Subash C Gupta, Kishore B Challagundla
{"title":"Influence of gut microbiota on systemic immune responses and cancer immunotherapy.","authors":"Swathi P Murakonda, Sahasra Balusu, Haritha Chava, Ajay B Murakonda, Reshmi Polneedi, Sushanth Bodduluri, Subash C Gupta, Kishore B Challagundla","doi":"10.1016/bs.ircmb.2024.12.005","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.12.005","url":null,"abstract":"<p><p>The gut microbiota is increasingly being recognized as a key player in the onset and progression of several human diseases, including malignancies. Recent research has shed light on the complex relationships between the gut microbiome and the effectiveness of cancer immunotherapy. Gaining a thorough understanding of how the gut microbiota influences immune responses during cancer treatments is critical for medical advancements. This review aims to delve into the intricate interactions between gut microbiota, the systemic immune system, and cancer immunotherapy. Additionally, as the gut microbiota can contribute to immune-related adverse effects, we explored possible interventions to alleviate these side effects and reviewed microbiota-targeted strategies that could enhance the success of cancer immunotherapies.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"395 ","pages":"23-66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in metastatic prostate cancer circulating tumor cell enrichment technologies and clinical studies. 转移性前列腺癌循环肿瘤细胞富集技术及临床研究进展。
3区 生物学
International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-07-29 DOI: 10.1016/bs.ircmb.2024.06.005
Naira Essam Abou-Ghali, Paraskevi Giannakakou
{"title":"Advances in metastatic prostate cancer circulating tumor cell enrichment technologies and clinical studies.","authors":"Naira Essam Abou-Ghali, Paraskevi Giannakakou","doi":"10.1016/bs.ircmb.2024.06.005","DOIUrl":"10.1016/bs.ircmb.2024.06.005","url":null,"abstract":"<p><p>Circulating tumor cells (CTCs) have emerged as a pivotal tool that enables molecular interrogation of patient tumor cells and association with clinical outcomes. In prostate cancer specifically, where tumor biopsies from patients with bone metastasis are extremely challenging, CTCs offer a viable and established source of tumor \"biopsy\". While the prognostic value of CTC enumeration in metastatic prostate cancer is established, there is a compelling need for molecular CTC characterization for effective patient stratification and disease management. The clinical utility of CTCs has been advanced by the evolution of enrichment technologies and their molecular characterization. Enrichment technologies have evolved from strictly EpCAM-based enrichment to antigen-agnostic enrichment, while their clinical utility has evolved from enumeration to advanced downstream analyses including CTC proteomics, transcriptomics and genomics. This chapter offers a comprehensive overview of recent advancements in CTC enrichment and analytical technologies while highlighting pivotal clinical studies in prostate cancer, that utilize CTCs to determine the molecular basis of clinical response and resistance, to assist in disease management and treatment customization.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"392 ","pages":"151-175"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic alteration in cervical cancer induced by human papillomavirus. 人乳头瘤病毒诱发宫颈癌的表观遗传改变。
3区 生物学
International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-04 DOI: 10.1016/bs.ircmb.2024.09.001
Elisa-Elvira Figueroa-Angulo, Jonathan Puente-Rivera, Yussel Fernando Perez-Navarro, Edgar Mendieta Condado, María-Elizbeth Álvarez-Sánchez
{"title":"Epigenetic alteration in cervical cancer induced by human papillomavirus.","authors":"Elisa-Elvira Figueroa-Angulo, Jonathan Puente-Rivera, Yussel Fernando Perez-Navarro, Edgar Mendieta Condado, María-Elizbeth Álvarez-Sánchez","doi":"10.1016/bs.ircmb.2024.09.001","DOIUrl":"10.1016/bs.ircmb.2024.09.001","url":null,"abstract":"<p><p>The critical role of a subset of Human Papillomavirus in cervical cancer has been widely acknowledged and studied. Despite progress in our understanding of the viral molecular mechanisms of pathogenesis, knowledge of how infection with HPV oncogenic variants progresses from latent infection to incurable cancer has not been completely elucidated. In this paper we reviewed the relationship between HPV infection and epigenetic mechanisms such as histone acetylation and deacetylation, DNA methylation and non-coding RNAs associated with this infection and the carcinogenic process.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"25-66"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revisiting epigenetic regulation in cancer: Evolving trends and translational implications. 回顾表观遗传调控在癌症：演变趋势和翻译意义。
3区 生物学
International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-04 DOI: 10.1016/bs.ircmb.2024.09.002
Mohammad Afsar Khan, Dhruv Mishra, Ranjan Kumar, Hifzur R Siddique
{"title":"Revisiting epigenetic regulation in cancer: Evolving trends and translational implications.","authors":"Mohammad Afsar Khan, Dhruv Mishra, Ranjan Kumar, Hifzur R Siddique","doi":"10.1016/bs.ircmb.2024.09.002","DOIUrl":"10.1016/bs.ircmb.2024.09.002","url":null,"abstract":"<p><p>Cancer is a leading cause of mortality worldwide. The evolving role of epigenetics and tumor microenvironments of cancer pose significant challenges to the management of cancer. Besides genetics, epigenetic changes play a crucial role in the alteration of cellular machinery, progression, metastasis, epithelial-mesenchymal transition, and chemoresistance. Epigenetic changes such as DNA and RNA methylation, histone modifications, and chromatin modeling directly or indirectly influence the different stages of cancer from initiation to chemoresistant phenotype. In addition, alterations in the epigenetic machinery, such as hypo- or hyperactivation of proteins involved in epigenetic modifications, can lead to different health complications, including cancer. Recently, epi-drugs or epigenetic drugs offer emerging hope for the treatment and management of this deadly disease. Various epigenetic drugs targeting factors responsible for epigenetic modifications in cancer are currently under clinical trials. This chapter provides an overview of epigenetic modifications, their clinical implications, and the potential of epigenetic drugs for cancer treatment.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"1-24"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-rhythmic modulators of the circadian system: A new class of circadian modulators. 昼夜节律系统的非节律调制器：一类新的昼夜节律调制器。
3区 生物学
International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-05-09 DOI: 10.1016/bs.ircmb.2024.04.003
Leonardo Vinícius Monteiro de Assis, Henrik Oster
{"title":"Non-rhythmic modulators of the circadian system: A new class of circadian modulators.","authors":"Leonardo Vinícius Monteiro de Assis, Henrik Oster","doi":"10.1016/bs.ircmb.2024.04.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.04.003","url":null,"abstract":"<p><p>The temporal organization of biological processes is critical for an organism's fitness and survival. An internal circadian clock network coordinates the alignment between the external and internal milieus via an array of systemic factors carrying temporal information such as core body temperature, autonomic activity, hormonal secretion, and behavioral functions. Collectively, these so called zeitgebers are characterized by strong temporal variations (i.e., high amplitudes). At the same time, target tissues show time windows of highest and lowest sensitivity to specific zeitgebers and, in this way, tissues can further modulate the effect of zeitgeber input in a process known as circadian gating. Such interplay between systemic signals and local circadian gating, however, suggests an additional level of temporal control-the resetting of target tissue rhythms in response to altered levels of tonic (i.e., non-rhythmic) signals. The recently identified tuning of liver transcriptome rhythms by thyroid hormones (THs) is one example of such regulation. THs show low-amplitude rhythms in the serum levels that are easily disrupted by altered thyroid states. At the same time, circadian rhythms in TH target tissues, such as liver, are markedly affected by alterations in TH state. Temporal regulation of TH target genes in other tissues suggests similar effects across the body. This chapter describes the rationale, experimental evidence, and potential consequences of this new level of circadian regulators.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"393 ","pages":"141-162"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of circulating tumor DNA as a biomarker for diagnosis and response to therapies in cancer patients. 循环肿瘤DNA作为癌症患者诊断和治疗反应的生物标志物的鉴定。
3区 生物学
International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-07 DOI: 10.1016/bs.ircmb.2024.08.006
Ronan W Hsieh, Lynn K Symonds, Jason Siu, Stacey A Cohen
{"title":"Identification of circulating tumor DNA as a biomarker for diagnosis and response to therapies in cancer patients.","authors":"Ronan W Hsieh, Lynn K Symonds, Jason Siu, Stacey A Cohen","doi":"10.1016/bs.ircmb.2024.08.006","DOIUrl":"10.1016/bs.ircmb.2024.08.006","url":null,"abstract":"<p><p>The sampling of circulating biomarkers provides an opportunity for non-invasive evaluation and monitoring of cancer activity. In modern day practice, this has typically been in the form of circulating tumor DNA (ctDNA) detected in plasma. The field of ctDNA has been a burgeoning technology, with prominent applications for blood-based cancer screening and in disease status assessment, especially after curative-intent surgery to evaluate for minimal residual disease (MRD). Clinical applications for the latter show an incredibly high sensitivity in certain cancer types with a need for additional studies to determine how much clinical decision-making should be adapted based on ctDNA results and which cancer types, stages, and treatments are best informed by ctDNA results. This chapter provides an overview of ctDNA detection as tool for cancer screening, detecting MRD, and/or molecularly characterizing a cancer, highlighting the rapidly amassing research as a prognostic biomarker and emerging data on ctDNA as a predictive biomarker.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"391 ","pages":"43-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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