International review of cell and molecular biology最新文献_第2页

Role of miRNAs as epigenetic regulators of immune checkpoints in lung cancer immunity.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI: 10.1016/bs.ircmb.2024.08.002

Irene Cánovas-Cervera, Elena Nacher-Sendra, Guillermo Suay, Agustin Lahoz, José Luis García-Giménez, Salvador Mena-Mollá

{"title":"Role of miRNAs as epigenetic regulators of immune checkpoints in lung cancer immunity.","authors":"Irene Cánovas-Cervera, Elena Nacher-Sendra, Guillermo Suay, Agustin Lahoz, José Luis García-Giménez, Salvador Mena-Mollá","doi":"10.1016/bs.ircmb.2024.08.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.08.002","url":null,"abstract":"The advent of immunotherapy in cancer has provided new avenues in the treatment of many malignancies at various stages. Specifically, immune checkpoint inhibitors (ICIs) have transformed the field of lung cancer treatment. However, since some tumors can evade the immune system, not all patients respond properly. Recent research has provided evidence showing how microRNAs (miRNAs) are involved in regulating many immune checkpoints. MiRNAs have demonstrated their ability to modulate immune evasion of tumor cells. Currently, reliable markers are being sought to predict the efficacy of immunotherapy in these types of cancers. Therefore, the association of serum miRNAs and the response of ICIs in lung cancer is under study. Many miRNA molecules and their corresponding target genes have been identified in the regulation of chemoresistance. Therefore, elucidating how these miRNAs control the function of immune checkpoints, as well as the effectiveness of therapies based on ICIs set the basis for the development of new biomarkers to predict treatment response to ICIs. This chapter delves into the molecular role of miRNAs interacting with ICs, such as PD-1 and PD-L1, and the clinical utility of miRNAs, such as miR-16, miR-146a, and miR-335, in predicting treatment response to ICI-based therapy in lung cancer. The aim is to provide a deep insight of the current landscape, serving as a cornerstone for further research.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"109-139"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding frontiers in liquid biopsy-discovery and validation of circulating biomarkers in renal cell carcinoma and bladder cancer.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-12 DOI: 10.1016/bs.ircmb.2024.08.005

Sabareeswaran Krishnan, Shruthi Kanthaje, Punchappady Devasya Rekha, M Mujeeburahiman, Chandrahas Koumar Ratnacaram

{"title":"Expanding frontiers in liquid biopsy-discovery and validation of circulating biomarkers in renal cell carcinoma and bladder cancer.","authors":"Sabareeswaran Krishnan, Shruthi Kanthaje, Punchappady Devasya Rekha, M Mujeeburahiman, Chandrahas Koumar Ratnacaram","doi":"10.1016/bs.ircmb.2024.08.005","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.08.005","url":null,"abstract":"Renal cell carcinoma (RCC) and Bladder cancer (BC) are two lethal urological cancers that require diagnosis at their earliest stage causing decreasing survival rates in case of aggressive disease. However, there is no reliable circulating marker in blood or urine for their less or non-invasive diagnosis. Our objective was to review the potential circulating biomarkers, namely proteins, micro-RNA (miRNA), long non-coding RNA (lncRNA), and circulating tumour cells (CTCs) for which we performed a PubMed-based literature search of biomolecules (protein, miRNA, lncRNA and CTCs) found as circulating biomarkers in blood and urine for the early detection of RCC and BC. Among the numerous studies, certain biomolecules represent promising early-stage biomarkers such as proteins (NNMT, LCP1, and NM23A; KIM1), mi-RNAs (5-panel: miR-193a-3p, miR-362, miR-572, miR-378, and miR-28-5p; miR-200a) and lncRNAs (5-panel: LET, PVT1, PANDAR, PTENP1 and linc00963; GIHCG) for RCC. Similarly, proteins (APOA1), miRNAs (7-panel: miR-7-5p, miR-22-3p, miR-29a-3p, miR-126-5p, miR- 200a-3p, miR-375, and miR-423-5p; miRNA 181a, miRNA 30c, and miRNA 570) and lncRNAs (3-panel: MALAT1, MEG3, and SNHG16; exosomal derived 3-panel: PCAT-1, UBC1 and SNHG16; H19) were reported in BC subjects. Notably, the majority of the biomarkers presented for early detection in RCC cases were found in blood, while in urine for BC. Our results reveal that though a plethora of circulating biomarkers show early diagnostic ability, all of them are still bench-only biomarkers and require further validation. Adequate clinical trials/studies testing which of these potential markers individually or in combination, will become clinically applicable still remain elusive.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"391 ","pages":"135-197"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of cell-free circulating epigenomic biomarkers for early diagnosis and response to therapies in breast cancer patients.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1016/bs.ircmb.2024.10.003

Pooja Ratre, Suresh Thareja, Pradyumna Kumar Mishra

{"title":"Identification of cell-free circulating epigenomic biomarkers for early diagnosis and response to therapies in breast cancer patients.","authors":"Pooja Ratre, Suresh Thareja, Pradyumna Kumar Mishra","doi":"10.1016/bs.ircmb.2024.10.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.10.003","url":null,"abstract":"The increasing prevalence of breast cancer presents a significant global health challenge, highlighting the urgent need for improved diagnostic and treatment monitoring methods. The non-invasive nature of cell-free circulating epigenomic biomarkers, such as methylated DNA (metDNA) and microRNAs (miRNAs), offers a reassuring approach to identifying breast cancer patients in the early stages and assessing their response to therapy. This approach holds great promise for diagnosis and treatment evaluation, prioritizing patient comfort and well-being. Cell-free circulating metDNA and miRNAs are released into the bloodstream from dying tumor cells through apoptosis and necrosis, carrying tumor-specific genetic and epigenetic changes. These changes encompass alterations in DNA methylation patterns, are pivotal in regulating gene expression, and are frequently disrupted in cancer. The interplay between these processes and the dynamic release of epigenomic biomarkers provides a real-time snapshot of the genetic and epigenetic features of the tumor. Integrating the analysis of metDNA and miRNA biomarkers into clinical practice can facilitate the early detection of breast cancer and improve the precision of treatment monitoring. By tracking changes in these biological markers, healthcare professionals can make informed decisions regarding modifications to therapy, ultimately enhancing patient outcomes. Gaining insights into the underlying mechanisms of cell-free circulating epigenomic biomarkers offers a groundbreaking approach to diagnosing and treating breast cancer.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"391 ","pages":"95-134"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin 10: Bridging the chasms in the immune landscape of multiple myeloma.

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-13 DOI: 10.1016/bs.ircmb.2024.08.003

Queenie Fernandes, Abdul W Ansari, Karama Makni-Maalej, Maysaloun Merhi, Said Dermime, Aamir Ahmad, Shahab Uddin

{"title":"Interleukin 10: Bridging the chasms in the immune landscape of multiple myeloma.","authors":"Queenie Fernandes, Abdul W Ansari, Karama Makni-Maalej, Maysaloun Merhi, Said Dermime, Aamir Ahmad, Shahab Uddin","doi":"10.1016/bs.ircmb.2024.08.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.08.003","url":null,"abstract":"Multiple myeloma (MM) is a complex hematologic malignancy characterized by the abnormal proliferation of plasma cells in the bone marrow, leading to significant clinical challenges and a high burden of morbidity and mortality. Interleukin 10 (IL-10), a cytokine with potent anti-inflammatory properties, has emerged as a critical player in the pathobiology of MM. This work delves into the multifaceted role of IL-10 in MM, exploring its contributions to tumor growth, immune evasion, and drug resistance. Here, we examine IL-10's interactions with various immune cells within the bone marrow microenvironment and its potential as a circulatory biomarker for MM. Furthermore, we particularly lay emphasis on the prognostic and diagnostic implications of IL-10 levels in MM patients and evaluate the therapeutic prospects of targeting IL-10 in MM treatment regimens. By synthesizing current research, this review aims to enhance the understanding of IL-10 as a circulatory biomarker in MM and to highlight novel avenues for therapeutic intervention, thereby translating to improved clinical outcomes for MM patient.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"391 ","pages":"199-222"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of chemokine receptors in transplant rejection and graft-versus-host disease. 趋化因子受体在移植排斥反应和移植物抗宿主疾病中的作用。

3区生物学

International review of cell and molecular biology Pub Date : 2024-08-15 DOI: 10.1016/bs.ircmb.2024.07.004

Paula Alonso-Guallart,David Harle

{"title":"Role of chemokine receptors in transplant rejection and graft-versus-host disease.","authors":"Paula Alonso-Guallart,David Harle","doi":"10.1016/bs.ircmb.2024.07.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.07.004","url":null,"abstract":"Organ transplantation increases life expectancy and improves the quality of life of patients experiencing specific conditions such as terminal organ failure. Despite matching efforts between donor and recipient, immune activation can interfere with allograft survival after transplantation if immunosuppression is not used. With both innate and adaptive responses, this is a complicated immunological process. This can lead to organ rejection, or graft-versus-host disease (GVHD), depending on the origin of the immune response. Inflammatory factors, such as chemokine receptors and their ligands, are involved in a wide variety of immunological processes, including modulating transplant rejection or GVHD, therefore, chemokine biology has been a major focus of transplantation studies. These molecules attract circulating peripheral leukocytes to infiltrate into the allograft and facilitate dendritic and T cell trafficking between lymph nodes and the graft during the allogeneic response. In this chapter, we will review the most relevant chemokine receptors such as CXCR3 and CCR5, among others, and their ligands involved in the process of allograft rejection for solid organ transplantation and graft-versus-host disease in the context of hematopoietic cell transplantation.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"8 1","pages":"95-123"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemokine receptors and their ligands in breast cancer: The key roles in progression and metastasis. 乳腺癌中的趋化因子受体及其配体：乳腺癌进展和转移中的关键作用。

3区生物学

International review of cell and molecular biology Pub Date : 2024-08-05 DOI: 10.1016/bs.ircmb.2024.07.002

Julio Valdivia-Silva,Alberto Chinney-Herrera

引用次数: 0

Role of chemokine receptors in gastrointestinal mucosa. 趋化因子受体在胃肠粘膜中的作用。

3区生物学

International review of cell and molecular biology Pub Date : 2024-05-31 DOI: 10.1016/bs.ircmb.2024.02.003

Brett Bell,Kevin Flores-Lovon,Luis A Cueva-Chicaña,Rodney Macedo

{"title":"Role of chemokine receptors in gastrointestinal mucosa.","authors":"Brett Bell,Kevin Flores-Lovon,Luis A Cueva-Chicaña,Rodney Macedo","doi":"10.1016/bs.ircmb.2024.02.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.02.003","url":null,"abstract":"Chemokine receptors are essential for the immune response in the oral and gut mucosa. The gastrointestinal mucosa is characterized by the presence of immune populations because it is susceptible to inflammatory and infectious diseases, necessitating immune surveillance. Chemokine receptors are expressed on immune cells and play a role in gastrointestinal tissue-homing, although other non-immune cells also express them for various biological functions. CCR9, CXCR3 and CXCR6 play an important role in the T cell response in inflammatory and neoplastic conditions of the gastrointestinal mucosa. However, CXCR6 could also be found in gastric cancer cells, highlighting the different roles of chemokine receptors in different pathologies. On the other hand, CCR4 and CCR8 are critical for Treg migration in gastrointestinal tissues, correlating with poor prognosis in mucosal cancers. Other chemokine receptors are also important in promoting myeloid infiltration with context-dependent roles. Further, CXCR4 and CXCR7 are also present in gastrointestinal tumor cells and are known to stimulate proliferation, migration, and invasion into other tissues, among other pro-tumorigenic functions. Determining the processes underlying mucosal immunity and creating tailored therapeutic approaches for gastrointestinal diseases requires an understanding of the complex interactions that occur between chemokine receptors and their ligands in these mucosal tissues.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"8 1","pages":"20-52"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemotactic signaling pathways in prostate cancer: Implications in the tumor microenvironment and as potential therapeutic targets. 前列腺癌的趋化信号通路：对肿瘤微环境的影响以及潜在的治疗靶点。

3区生物学

International review of cell and molecular biology Pub Date : 2024-05-06 DOI: 10.1016/bs.ircmb.2024.03.008

Zoila A Lopez-Bujanda,Shawn H Hadavi,Vicenç Ruiz De Porras,Eva Martínez-Balibrea,Matthew C Dallos

{"title":"Chemotactic signaling pathways in prostate cancer: Implications in the tumor microenvironment and as potential therapeutic targets.","authors":"Zoila A Lopez-Bujanda,Shawn H Hadavi,Vicenç Ruiz De Porras,Eva Martínez-Balibrea,Matthew C Dallos","doi":"10.1016/bs.ircmb.2024.03.008","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.03.008","url":null,"abstract":"Prostate cancer (PCa) stands as a significant global health concern, ranking among the leading causes of cancer deaths in men. While there are several treatment modalities for localized PCa, metastatic castration-resistant PCa (mCRPC) remains incurable. Despite therapeutic advancements showing promise in mCRPC, their impact on overall survival has been limited. This chapter explores the process by which tumors form, reviews our current understanding of PCa progression to mCRPC, and addresses the challenges of boosting anti-tumor immune responses in these tumors. It specifically discusses how chemotactic signaling affects the tumor microenvironment and its role in immune evasion and cancer progression. The chapter further examines the rationale of directly or indirectly targeting these pathways as adjuvant therapies for mCRPC, highlighting recent pre-clinical and clinical studies currently underway. The discussion emphasizes the potential of targeting specific chemokines and chemokine receptors as combination therapies with mainstream treatments for PCa and mCRPC to maximize long-term survival for this deadly disease.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"31 1","pages":"162-205"},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemokine receptors in primary and secondary lymphoid tissues. 原发性和继发性淋巴组织中的趋化因子受体。

3区生物学

International review of cell and molecular biology Pub Date : 2024-04-27 DOI: 10.1016/bs.ircmb.2023.11.003

Hector Cordero

{"title":"Chemokine receptors in primary and secondary lymphoid tissues.","authors":"Hector Cordero","doi":"10.1016/bs.ircmb.2023.11.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.11.003","url":null,"abstract":"Chemokine receptors are a complex superfamily of surface G protein-coupled receptors present mostly in leukocytes. In this chapter, we review the presence and functions of chemokine receptors in the immune cells of the primary and secondary lymphoid organs. Those include bone marrow, thymus, spleen, lymph nodes, and Peyer's patches as the main components of the gut-associated lymphoid tissue. There are general groups of chemokine receptors: conventional and atypical. We will mostly cover the role of conventional chemokine receptors, which are divided into four classes (CC, CXC, CX3C, and XC). Some relevant members are CXCR4, CXCR5, CCR4 and CCR7. For example, CXCR4 is a key chemokine receptor in the bone marrow controlling from the homing of progenitor cells into the bone marrow, the development of B cells, to the homing of long-lived plasma cells to this primary lymphoid organ. CCR7 and CCR4 are two of the main players in the thymus. CCR7 along with CCR9 control the traffic of thymic seed progenitors into the thymus, while CCR4 and CCR7 are critical for the entry of thymocytes into the medulla and as controllers of the central tolerance in the thymus. CXCR4 and CXCR5 have major roles in the spleen, guiding the maturation and class-switching of B cells in the different areas of the germinal center. In the T-cell zone, CCR7 guides the differentiation of naïve T cells. CCR7 also controls and directs the entry of T cells, B cells, and dendritic cells into secondary lymphoid tissues, including the spleen and lymph nodes. As new technologies emerge, techniques such as high dimensional spectral flow cytometry or single-cell sequencing allow a more comprehensive knowledge of the chemokine receptor network and their ligands, as well as the discovery of new interactions mediating unknown and overlooked mechanisms in health and disease.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"11 1","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic orchestration of the DNA damage response: Insights into the regulatory mechanisms. DNA 损伤反应的表观遗传协调：洞察调控机制

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-04-05 DOI: 10.1016/bs.ircmb.2024.03.003

Atanu Mondal, Agniswar Sarkar, Dipanwita Das, Amrita Sengupta, Aindrila Kabiraj, Payel Mondal, Rachayita Nag, Shravanti Mukherjee, Chandrima Das

{"title":"Epigenetic orchestration of the DNA damage response: Insights into the regulatory mechanisms.","authors":"Atanu Mondal, Agniswar Sarkar, Dipanwita Das, Amrita Sengupta, Aindrila Kabiraj, Payel Mondal, Rachayita Nag, Shravanti Mukherjee, Chandrima Das","doi":"10.1016/bs.ircmb.2024.03.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.03.003","url":null,"abstract":"The DNA damage response (DDR) is a critical cellular mechanism that safeguards genome integrity and prevents the accumulation of harmful DNA lesions. Increasing evidence highlights the intersection between DDR signaling and epigenetic regulation, offering profound insights into various aspects of cellular function including oncogenesis. This comprehensive review explores the intricate relationship between the epigenetic modifications and DDR activation, with a specific focus on the impact of viral infections. Oncogenic viruses, such as human papillomavirus, hepatitis virus (HBV or HCV), and Epstein-Barr virus have been shown to activate the DDR. Consequently, these DNA damage events trigger a cascade of epigenetic alterations, including changes in DNA methylation patterns, histone modifications and the expression of noncoding RNAs. These epigenetic changes exert profound effects on chromatin structure, gene expression, and maintenance of genome stability. Importantly, elucidation of the viral-induced epigenetic alterations in the context of DDR holds significant implications for comprehending the complexity of cancer and provides potential targets for therapeutic interventions.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"387 ","pages":"99-141"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0