International review of cell and molecular biology最新文献_第2页

Autophagy meets plant virology: From molecular crosstalk to outstanding challenges. 自噬与植物病毒学：从分子串扰到突出的挑战。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2026-02-27 DOI: 10.1016/bs.ircmb.2026.02.002

Miryam Pérez-Cañamás, Carmen Hernández

{"title":"Autophagy meets plant virology: From molecular crosstalk to outstanding challenges.","authors":"Miryam Pérez-Cañamás, Carmen Hernández","doi":"10.1016/bs.ircmb.2026.02.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2026.02.002","url":null,"abstract":"Autophagy is an evolutionarily conserved degradation and recycling pathway that plays essential roles in plant development, stress adaptation, and immunity. Over the past decade, increasing evidence has revealed that autophagy also shapes the outcome of plant-virus interactions. This review summarizes current understanding of the plant autophagy machinery as well as the experimental approaches used to monitor autophagic flux during viral infection. We then explore the diverse roles of autophagy in the plant-virus interface, highlighting its function as an antiviral mechanism that targets viral components for degradation, and the counterstrategies viruses employ to inhibit or evade this defense. Conversely, some viruses exploit autophagy or its components to facilitate replication, movement, or systemic infection, underscoring its dual nature in plant virology. Recent studies have expanded knowledge of selective autophagy receptors that mediate targeted degradation of viral factors, yet the diversity and specificity of these receptors are likely far from fully characterized. Finally, we discuss outstanding questions such as the mechanisms underlying virus-induced autophagy, the factors determining its switch between antiviral and proviral roles, its crosstalk with other cellular pathways, and the molecular signatures that guide the selective recognition of viral or host proteins. Overall, autophagy emerges as an important regulatory hub in plant-virus interactions, integrating antiviral defense and viral adaptation in a finely tuned balance.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"406 ","pages":"43-85"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy and type 2 diabetes: Bridging the gap in metabolic health. 自噬和2型糖尿病：弥合代谢健康的差距。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-09-13 DOI: 10.1016/bs.ircmb.2025.08.006

Agustina Creus, Leonardo Ortega, David Sebastián

引用次数: 0

Autophagy in cancer cachexia: From mechanisms to therapeutic opportunities. 癌症恶病质中的自噬：从机制到治疗机会。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-09-06 DOI: 10.1016/bs.ircmb.2025.08.008

Riccardo Ballarò, Fabio Penna, Marc Beltrà

{"title":"Autophagy in cancer cachexia: From mechanisms to therapeutic opportunities.","authors":"Riccardo Ballarò, Fabio Penna, Marc Beltrà","doi":"10.1016/bs.ircmb.2025.08.008","DOIUrl":"10.1016/bs.ircmb.2025.08.008","url":null,"abstract":"Cancer cachexia is a multifactorial syndrome characterized by body weight loss, muscle wasting, and systemic metabolic alterations, significantly contributing to patient morbidity and mortality. A key feature of cachexia is the excessive degradation of muscle proteins and mitochondria, largely mediated by autophagy. Although hyperactivation of autophagy has been widely recognized as a hallmark of cancer cachexia, its precise role in exacerbating muscle atrophy through enhanced proteolysis and mitochondrial disposal remains a subject of ongoing debate. This review provides a comprehensive overview of previous milestones and recent advancements in understanding autophagy's role in cancer cachexia, with particular focus on its impact on skeletal muscle and liver, as well as its contribution to tumor metabolic flexibility. Additionally, the review explores emerging therapeutic strategies aimed at modulating autophagy, including exercise, exercise mimetics, and novel molecules to selectively target specific branches of autophagy. By synthesizing current evidence, this review highlights the need for further research into the mechanisms underlying autophagy dysregulation in cancer cachexia and the potential for autophagy-based interventions to improve patient outcomes.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"403 ","pages":"85-121"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From autophagy to mitophagy: Quality control mechanisms in skeletal muscle. 从自噬到有丝自噬：骨骼肌质量控制机制。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI: 10.1016/bs.ircmb.2025.11.006

Eduardo Antuña, Nerea Menéndez-Coto, Paula Fernández-Guisasola, Ana Coto-Montes

{"title":"From autophagy to mitophagy: Quality control mechanisms in skeletal muscle.","authors":"Eduardo Antuña, Nerea Menéndez-Coto, Paula Fernández-Guisasola, Ana Coto-Montes","doi":"10.1016/bs.ircmb.2025.11.006","DOIUrl":"10.1016/bs.ircmb.2025.11.006","url":null,"abstract":"Autophagy is a process which is responsible for the maintenance of cellular homeostasis. This is achieved through the orchestration of both highly selective and non-selective degradation pathways, the purpose of which is the elimination of damaged structures. Recent findings have revealed that, in addition to its intracellular function, this organelle exhibits a remarkable \"social life\" and forms relationships with other cellular organelles. This has led to the discovery that mitochondrial quality is maintained not only through mitophagy, but also through extracellular mechanisms between cells. This has significantly expanded our understanding of tissue integrity. In skeletal muscle, autophagy, or autophagy, is a finely tuned process that plays a crucial role in maintaining physiological performance and adaptation. Disruption of autophagy has been linked to accelerated degeneration, metabolic dysfunction, and frailty. Although therapeutic manipulation of autophagy and mitophagy shows promise in restoring muscle health, major translational barriers persist. A more profound and nuanced exploration of autophagy flux in human muscle is imperative, underpinned by novel advanced cell biology technologies and predicated on satellite cells as the primary agents in muscle regeneration. The full therapeutic potential of autophagy could be harnessed to redefine interventions against muscle ageing and associated diseases. However, this would still require critical scrutiny of the long-term effects and systemic consequences.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"404 ","pages":"1-61"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-selective and selective autophagy as mediators of mechanical forces. 非选择性和选择性自噬作为机械力的介质。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-11-17 DOI: 10.1016/bs.ircmb.2025.10.007

Maraiza Alves Teixeira, Nicolas Dupont

{"title":"Non-selective and selective autophagy as mediators of mechanical forces.","authors":"Maraiza Alves Teixeira, Nicolas Dupont","doi":"10.1016/bs.ircmb.2025.10.007","DOIUrl":"10.1016/bs.ircmb.2025.10.007","url":null,"abstract":"Autophagy is a fundamental cell biological process that controls the quality and quantity of the eukaryotic cytoplasm. Dysfunctional autophagy, when defective or excessive, has been linked to human pathologies. Autophagy can randomly degrade cytoplasmic components in a non-selective manner commonly referred to as bulk autophagy. In contrast, selective forms of autophagy specifically target cytoplasmic structures such as organelles thereby being important for cellular quality control and organelle homeostasis. Recent studies demonstrate the role of bulk and selective autophagy in the integration of physical constraints. Mechanical forces, combine with biochemical signals control the development and the physiological functions of different organs and can also contribute to the progression of various diseases. The aim of this Review is to summarize and discuss our current knowledge on the role of autophagy in regulating a broad range of cellular responses, from morphology, metabolism, to inflammation and senescence, in the context of mechanical forces. Additionally, where relevant, we will also discuss the potential implications of mechanical stress-induced autophagy in pathologies.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"404 ","pages":"233-258"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The current findings and potential applications of breast cancer epigenetics. 乳腺癌表观遗传学的最新发现及潜在应用。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-10-25 DOI: 10.1016/bs.ircmb.2025.10.002

Yen-Vy Nguyen Thi, Quy Do Van, Hai Linh Duong Nguyen, Thanh Van Cao Thi, Dinh-Toi Chu

引用次数: 0

Role of autophagy in adipose tissue: Implications for metabolic health. 自噬在脂肪组织中的作用：对代谢健康的影响。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-09-20 DOI: 10.1016/bs.ircmb.2025.08.015

Núria Borràs-Ferré, Antonio Zorzano, Montserrat Romero

{"title":"Role of autophagy in adipose tissue: Implications for metabolic health.","authors":"Núria Borràs-Ferré, Antonio Zorzano, Montserrat Romero","doi":"10.1016/bs.ircmb.2025.08.015","DOIUrl":"10.1016/bs.ircmb.2025.08.015","url":null,"abstract":"Autophagy is increasingly considered a key regulator of adipose tissue biology, with growing evidence linking this cellular degradation pathway to crucial aspects of metabolic health. In recent years, research has revealed that autophagy influences adipocyte differentiation, lipid handling, mitochondrial quality control, and inflammatory responses within adipose depots. These functions are essential for maintaining the plasticity and functionality of both white and brown adipose depots. As our understanding of how autophagy shapes fat tissue dynamics grows, this process is emerging as a promising target for treating obesity and related metabolic disorders. Future clinical applications may involve precision therapeutics that combine pharmacological, dietary, and genetic tools to modulate autophagy in an adipose tissue-specific and personalized manner. In this review, we summarize current knowledge of the role of autophagy in adipose tissue physiology and its impact on systemic metabolism. We also discuss how autophagy dysregulation contributes to metabolic diseases such as obesity and insulin resistance, and therefore its potential use as a therapeutic target in clinical practice.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"403 ","pages":"145-176"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytokine-based immunotherapy in pancreatic cancer. 基于细胞因子的胰腺癌免疫治疗。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-03-27 DOI: 10.1016/bs.ircmb.2025.03.001

Andrés Gordo-Ortiz, Inés Ortiz-de-Solórzano, Flor Navarro

{"title":"Cytokine-based immunotherapy in pancreatic cancer.","authors":"Andrés Gordo-Ortiz, Inés Ortiz-de-Solórzano, Flor Navarro","doi":"10.1016/bs.ircmb.2025.03.001","DOIUrl":"10.1016/bs.ircmb.2025.03.001","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, characterized by a highly fibrotic and immunosuppressive tumor microenvironment that poses significant challenges to conventional therapies. In recent years, immunotherapy has emerged as a promising treatment approach for PDAC, yielding notable clinical results. While checkpoint blockade inhibitors and chimeric antigen receptor (CAR) T-cell therapies are the most well-known immunotherapies widely tested in clinical trials, cytokine therapy has also demonstrated effectiveness against PDAC in both preclinical and clinical settings, often in combination with other treatments rather than as monotherapy. This chapter explores the emerging potential of cytokine-based immunotherapies, focusing on strategies such as cytokine modulation, adoptive cell transfer therapies (including CAR-T and cytokine-induced killer cells), and combination treatments. We review preclinical approaches involving cytokine engineering and modulation of cell signaling, as well as various clinical studies specifically targeting pancreatic cancer. Although past and ongoing clinical trials highlight the promise of cytokine-related therapeutics as innovative treatment avenues, the full potential of this rapidly evolving field remains to be fully realized.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"401 ","pages":"1-46"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in computational tools in proteomics: Revolutionizing data analysis. 蛋白质组学计算工具的进步：革命性的数据分析。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-12-02 DOI: 10.1016/bs.ircmb.2025.11.003

Lubna Therachiyil, Anjana Anand, Aamir Ahmad, Hesham M Korashy, Shahab Uddin

{"title":"Advancements in computational tools in proteomics: Revolutionizing data analysis.","authors":"Lubna Therachiyil, Anjana Anand, Aamir Ahmad, Hesham M Korashy, Shahab Uddin","doi":"10.1016/bs.ircmb.2025.11.003","DOIUrl":"10.1016/bs.ircmb.2025.11.003","url":null,"abstract":"Proteomics generates highly sophisticated and complex data. This necessitates the importance of computational tools and databases that could untangle this complexity and deliver meaningful biological insights. These tools or algorithms that offer curated repositories are critically useful for the identification, characterization and functional analysis of proteins. These repositories provide with essential data such as protein sequences, family nomenclature, domains, enzymatic properties, structures, post-translational modifications (PTMs), interactions, and functional annotations. Despite the fact that significant advancements have been done in proteomics data analysis tools, challenges prevail due to the dynamic nature of proteins, data complexity and data integration issues. To address these issues, developing a comprehensive and robust platform by integrating diverse databases and bioinformatic analytical tools, coupled with scalable algorithms is critical for data integration. This review envisions the common proteomic approaches, data acquisition, data processing, and functional analysis of proteomics data and also emphasize on the importance and advancements of proteomics technologies with the integration of computational methods that inherited proteomics to unravel biologicals processes and disease etiology. The review also notes down the challenges faced by researchers during data analysis and possible ways to prevent this in the future such as expanding cloud computing infrastructure for large-scale data processing as well as management to ensure easy accessibility and computational efficiency. Future advancements in data analysis should focus on enhancing data integration, improving analytical precision, and leveraging cloud computing, Artificial Intelligence, and machine learning for large-scale data processing, that could help in driving improvements in biomedical research and therapeutic development.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"402 ","pages":"89-142"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148030556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neoantigen-based TCR-T therapy in solid tumors. 基于新抗原的TCR-T治疗实体瘤。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI: 10.1016/bs.ircmb.2025.11.001

Wenjie Feng, Daichao Wu, Yukun Li

引用次数: 0