International review of cell and molecular biology最新文献_第3页

Introduction to microbiomes in health and diseases. 微生物组在健康和疾病中的介绍。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1016/bs.ircmb.2024.12.010

Prachi Agrawal, Prachi Mendhey, Robins Kumar, Subham Patel, Prakash Kumar Kaushik, Abhishek Dadsena, Santosh Kumar

引用次数: 0

Link between dysbiosis and cancer: Contributing mechanisms and factors. 生态失调和癌症之间的联系：促进机制和因素。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-20 DOI: 10.1016/bs.ircmb.2024.12.004

Naimah Turner, Jocelynn Colunga-Minutti, Sayan Alekseev, Robert R Jenq, Roza Nurieva

引用次数: 0

Effect of diet and lifestyle on microbiome composition. 饮食和生活方式对微生物组成的影响。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-26 DOI: 10.1016/bs.ircmb.2024.12.008

Rishibha Gupta, Smriti Gaur

引用次数: 0

Clinical development complexity of TGF-β inhibition: From fibrosis to cancer immunotherapy. TGF-β抑制的临床发展复杂性：从纤维化到癌症免疫治疗。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-21 DOI: 10.1016/bs.ircmb.2025.01.005

Gabriel Gallo-Oller, María Isabel Guillén-Antonini, Javier Dotor

{"title":"Clinical development complexity of TGF-β inhibition: From fibrosis to cancer immunotherapy.","authors":"Gabriel Gallo-Oller, María Isabel Guillén-Antonini, Javier Dotor","doi":"10.1016/bs.ircmb.2025.01.005","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2025.01.005","url":null,"abstract":"More than four decades have passed since the discovery of Transforming Growth Factor beta (TGF-β) in 1981, a pivotal cytokine with profound implications in cell biology and potential clinical interventions for physio-pathological processes including fibrosis, immune-related disorders, chronic infections, vascular alterations, and the progression of tumour growth through invasiveness and metastasis. However, the introduction of a specific inhibitor targeting this cytokine into the pharmaceutical market remains elusive. Various molecular entities and therapeutic strategies, including small molecules, peptides, recombinant proteins (such as specific antibodies), oligonucleotides, and cellular-based therapies have been devised and subjected to clinical trials. These target the specific TGF-β molecular pathway, either directly or indirectly. The combination of different drug types, routes of administration, and clinical indications has generated substantial data, emphasizing significant variability in patient outcomes. Efforts to enhance the effectiveness of cancer immunotherapy by combining TGF-β inhibitors with other drugs and modulating complementary molecular targets have been explored over the past few decades. This approach aims to translate the promising preclinical efficacy of TGF-β blockade into commercially available drugs that are suitable for a broad spectrum of clinical indications. However, a clear path to address the lack of discernible efficacy and overcome the associated marketing challenges has not yet emerged. This review provides a comprehensive overview of the clinical development and emerging trends in TGF-β inhibitors and modulatory strategies, offering novel perspectives for addressing this persistent challenge.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"396 ","pages":"139-187"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dichotomy of IL-27 in tumor immunity. IL-27在肿瘤免疫中的二分法。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-25 DOI: 10.1016/bs.ircmb.2025.01.002

Aline Risson, Leire Arrizabalaga, Miriam Ezcurra-Hualde, Román García-Fuentes, Pedro Berraondo, Fernando Aranda

引用次数: 0

CTCs and liquid biopsies in patients with colorectal cancer. 结直肠癌患者的CTCs和液体活检。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-30 DOI: 10.1016/bs.ircmb.2024.10.001

Areeb Lutfi, Maaz Khan Afghan, Pashtoon Murtaza Kasi

引用次数: 0

Circulating biomarkers for diagnosis and response to therapies in cancer patients. 循环生物标志物用于癌症患者的诊断和治疗反应。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI: 10.1016/bs.ircmb.2024.08.007

Natália Marcéli Stefanes, Maria Eduarda Cunha-Silva, Lisandra de Oliveira Silva, Laura Otto Walter, Maria Cláudia Santos-Silva, Manas Ranjan Gartia

{"title":"Circulating biomarkers for diagnosis and response to therapies in cancer patients.","authors":"Natália Marcéli Stefanes, Maria Eduarda Cunha-Silva, Lisandra de Oliveira Silva, Laura Otto Walter, Maria Cláudia Santos-Silva, Manas Ranjan Gartia","doi":"10.1016/bs.ircmb.2024.08.007","DOIUrl":"10.1016/bs.ircmb.2024.08.007","url":null,"abstract":"Cancer presents a significant challenge to global health, driving worldwide concerted efforts to advance early detection, predict therapeutic response, and identify novel targeted therapies. Liquid biopsies emerge as promising avenues for discerning cancer biomarkers, offering less invasive approaches compared to conventional methods. Utilizing increasingly robust technologies, diverse bodily fluids can unveil genetic variants, epigenetic modifications, transcriptional alterations, and metabolomic signatures associated with cancer, thereby furnishing valuable insights for clinical management. This chapter intends to review the sources of cancer-related biomarkers found in circulation, prevalent techniques utilized for their identification, and the potential implications of different biomarker types on the management of cancer. Certain biomarkers currently used in clinical practice will be addressed, as well as potential biomarkers still in the study phase, and the inherent challenges in their practical implementation.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"391 ","pages":"1-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian rhythms in muscle health and diseases. 肌肉健康和疾病的昼夜节律。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-11-12 DOI: 10.1016/bs.ircmb.2024.10.002

Jeffrey J Kelu

{"title":"Circadian rhythms in muscle health and diseases.","authors":"Jeffrey J Kelu","doi":"10.1016/bs.ircmb.2024.10.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.10.002","url":null,"abstract":"All major life forms from bacteria to humans have internal clocks that regulate essential biological processes in a roughly 24-h cycle. In mammals, the central clock in the suprachiasmatic nucleus (SCN) is historically considered the top of a hierarchical organisation that dominates subordinate clocks in peripheral tissues and dictates the circadian behaviours of an organism. Recent studies, however, underscore the importance of the local circadian oscillators, such as the skeletal muscle clock, in regulating local metabolism and physiology. Studies in animal models show that the muscle peripheral clock per se is required for the expression of genes involved in glucose, lipid, and amino acid metabolism. Disruption of the muscle clock leads to glucose intolerance, insulin resistance, and alterations in muscle size and force. This highlights the vital role of the muscle clock in controlling muscle physiology and metabolism. In humans, a perturbation in the muscle circadian rhythms is seen in metabolic disorders such as type 2 diabetes, and muscle diseases such as dystrophies. Disruption of muscle metabolism is also seen when the internal rhythms are misaligned with the external rhythms (circadian misalignments) as in shift work. Understanding the mechanisms by which the muscle clock regulates circadian functions may help the development of new strategies, such as chronotherapy, to potentially prevent or treat muscle pathologies and maintain muscle health.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"393 ","pages":"45-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging interactions between circadian rhythms and extracellular vesicles. 昼夜节律与细胞外囊泡之间的相互作用。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-11-23 DOI: 10.1016/bs.ircmb.2024.11.001

Jacob G Smith

{"title":"Emerging interactions between circadian rhythms and extracellular vesicles.","authors":"Jacob G Smith","doi":"10.1016/bs.ircmb.2024.11.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.11.001","url":null,"abstract":"Circadian rhythms are present across species, tuning internal processes to daily changes in the environment. Driven by genetically encoded circadian clocks present throughout the body, and modulated by external inputs, the circadian system is a key player in metabolic control. However, the molecular mediators underlying coordination between cells and tissues are not well known. Extracellular vesicles (EVs) have emerged over recent years as important players in cell-cell and organ-organ communication, however the influence of circadian rhythms on EVs is not yet understood. Research into this area is still scarce, yet already offers glimpses into the potential impact of circadian rhythms on EV biology. In this review, recent discoveries that reveal, directly or indirectly, a potential role for circadian rhythms in EV abundance, properties, cargo and signalling functions are first discussed. Next, the feedback of EV signalling on circadian clocks is considered. Last, unanswered questions regarding the interaction between circadian rhythms and EVs are examined alongside potential approaches to address them. Overall, the circadian impact on EV signalling is an exciting yet understudied aspect that warrants further investigation.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"393 ","pages":"73-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver as a nexus of daily metabolic cross talk. 肝脏作为日常代谢串扰的纽带。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-06-25 DOI: 10.1016/bs.ircmb.2024.06.001

Christopher Litwin, Kevin B Koronowski

{"title":"Liver as a nexus of daily metabolic cross talk.","authors":"Christopher Litwin, Kevin B Koronowski","doi":"10.1016/bs.ircmb.2024.06.001","DOIUrl":"10.1016/bs.ircmb.2024.06.001","url":null,"abstract":"Over the course of a day, the circadian clock promotes a homeostatic balance between energy intake and energy expenditure by aligning metabolism with nutrient availability. In mammals, this process is driven by central clocks in the brain that control feeding behavior, the peripheral nervous system, and humoral outputs, as well as by peripheral clocks in non-brain tissues that regulate gene expression locally. Circadian organization of metabolism is critical, as circadian disruption is associated with increased risk of metabolic disease. Emerging evidence shows that circadian metabolism hinges upon inter-organ cross talk involving the liver, a metabolic hub that integrates many facets of systemic energy homeostasis. Here, we review spatiotemporal interactions, mainly metabolite exchange, signaling factors, and hormonal control, between the liver and skeletal muscle, pancreas, gut, microbiome, and adipose tissue. Modern society presents the challenge of circadian disturbances from rotating shift work to social jet lag and 24/7 food availability. Thus, it is important to better understand the mechanisms by which the clock system controls metabolic homeostasis and work toward targeted therapies.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"393 ","pages":"95-139"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0