International review of cell and molecular biology最新文献_第3页

Epigenetic regulation of cancer. 癌症的表观遗传调控。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 DOI: 10.1016/S1937-6448(26)00028-6

Sheila Spada, Lorenzo Galluzzi

引用次数: 0

Impact of different exercise modalities on mitophagy in human skeletal muscle. 不同运动方式对人体骨骼肌线粒体自噬的影响。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-11-07 DOI: 10.1016/bs.ircmb.2025.10.005

Cristóbal Muñoz-Medina, Alfonso Carriel-Nesvara, Javier Botella, Mauricio Castro-Sepulveda

{"title":"Impact of different exercise modalities on mitophagy in human skeletal muscle.","authors":"Cristóbal Muñoz-Medina, Alfonso Carriel-Nesvara, Javier Botella, Mauricio Castro-Sepulveda","doi":"10.1016/bs.ircmb.2025.10.005","DOIUrl":"10.1016/bs.ircmb.2025.10.005","url":null,"abstract":"Exercise induces profound mitochondrial adaptations in skeletal muscle, with different modalities uniquely influencing different branches of mitochondrial quality control (MQC). This review examines how endurance, resistance, and high-intensity interval training (HIIT) regulate mitophagy, the selective degradation of damaged mitochondria, in skeletal muscle (SkM). Research in rodents has shown that endurance exercise upregulates mitophagy primarily through the AMPK/PGC-1α signaling axis, promoting mitochondrial turnover and ensuring metabolic efficiency. In humans, high-intensity exercise increases mitophagy to a larger extent when compared to traditional endurance exercises. On the other hand, resistance exercise triggers alternative MQC mechanisms, including potential mitochondrial ejection. Collectively, these results suggest that mitophagy and MQC pathways are regulated in human SkM following exercise, but the specific molecular pathways seem to be specific to each exercise mode. Future studies should aim at disentangling the multiple mitophagy and MQC pathways in human SkM following exercise.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"404 ","pages":"63-79"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in ferroptosis research and applications. 铁下垂研究与应用进展。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-12-15 DOI: 10.1016/bs.ircmb.2025.12.004

Santhosh Kumar Yasam, N Vignesh, Senthilkumar Rajagopal

{"title":"Advances in ferroptosis research and applications.","authors":"Santhosh Kumar Yasam, N Vignesh, Senthilkumar Rajagopal","doi":"10.1016/bs.ircmb.2025.12.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2025.12.004","url":null,"abstract":"Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and redox imbalance. It has emerged as a pivotal mechanism implicated in various diseases, including cancer, chronic kidney diseases (CKD), neurodegenerative disorders, pulmonary fibrosis, chronic wounds, and viral infections such as COVID-19. This chapter presents a comprehensive overview of the molecular underpinnings of ferroptosis, emphasizing its key regulators-iron metabolism, lipid peroxidation pathways, and antioxidant defenses such as GPX4 and system Xc-. We explore recent advances highlighting the therapeutic potential of ferroptosis modulation across multiple pathological contexts. In cancer, ferroptosis inducers have shown efficacy in overcoming drug resistance and enhancing immunotherapy. In contrast, inhibition of ferroptosis offers protective effects in neurodegenerative diseases, ischemia-reperfusion injury, and chronic inflammatory conditions. Applications in nanomedicine have further enabled targeted delivery of ferroptosis modulators, expanding their clinical relevance. The chapter also discusses emerging roles of ferroptosis in wound healing, CKD and pulmonary fibrosis, with particular attention to COVID-19-related lung injury. Finally, we evaluate current therapeutic strategies, safety considerations, and potential clinical applications, along with future directions including biomarker development and personalized medicine. Our aim is to provide a unified perspective on ferroptosis as a disease-modifying mechanism and to highlight its growing importance as a therapeutic target across diverse clinical disciplines.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"405 ","pages":"149-186"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MRI acute/sub-acute ischemic stroke segmentation with deep learning: A comprehensive review. MRI急性/亚急性缺血性脑卒中的深度学习分割：全面回顾。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2026-01-23 DOI: 10.1016/bs.ircmb.2025.12.006

Mohammad Alshurbaji, Maregu Assefa, Said Boumaraf, Mohamed L Seghier, Taimur Hassan, Muzammal Naseer, Kamal Taha, Naoufel Werghi

{"title":"MRI acute/sub-acute ischemic stroke segmentation with deep learning: A comprehensive review.","authors":"Mohammad Alshurbaji, Maregu Assefa, Said Boumaraf, Mohamed L Seghier, Taimur Hassan, Muzammal Naseer, Kamal Taha, Naoufel Werghi","doi":"10.1016/bs.ircmb.2025.12.006","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2025.12.006","url":null,"abstract":"The segmentation of ischemic stroke lesions from Magnetic Resonance Imaging (MRI) images using deep learning (DL) techniques has emerged as a critical area of research in medical imaging. This article provides a comprehensive review of the current state-of-the-art methodologies in this domain, focusing on the advancements and challenges inherent in this field. Our review focuses on studies that utilize DL models for segmenting acute and sub-acute ischemic stroke lesions using MRI modalities. By systematically analyzing research from 2020 onward, we aim to clarify the advancements in the published models' effectiveness and provide a performance benchmark. This review stands out by comprehensively analyzing all the studies in this field, beyond the scope of prior reviews focused only on key publications. Additionally, this work serves as a comprehensive reference for researchers by compiling all relevant datasets, MRI modalities, evaluation metrics, loss functions, input data dimensionality, preprocessing, and augmentation techniques employed for this task. Additionally, we identify the challenges in this field and highlight the existing research gaps, in addition to proposing some directions for future work to enhance the effectiveness and accuracy of DL models in stroke lesion segmentation.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"405 ","pages":"219-274"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of bioinformatics and data science in studies of cancer epigenetics. 生物信息学与数据科学在癌症表观遗传学研究中的应用。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-10-30 DOI: 10.1016/bs.ircmb.2025.10.003

Dinh-Toi Chu, Trong-Duc Dao, Minh-Ha To, Tri Dung Trinh, Nhat-Le Bui

{"title":"Application of bioinformatics and data science in studies of cancer epigenetics.","authors":"Dinh-Toi Chu, Trong-Duc Dao, Minh-Ha To, Tri Dung Trinh, Nhat-Le Bui","doi":"10.1016/bs.ircmb.2025.10.003","DOIUrl":"10.1016/bs.ircmb.2025.10.003","url":null,"abstract":"The dysregulation at the epigenetic level, such as DNA methylation, histone modifications, and changes in noncoding RNA, plays an important role in many serious human pathologies, including cancers. Epigenetics modulates the expression of tumor-related genes without any changes in the DNA sequences, thus understanding the epigenetic profile is a promising way to clarify the underlying mechanism of cancers as well as other diseases. Specific techniques like chromatin immunoprecipitation followed by sequencing (ChIP-seq), whole-genome bisulfite sequencing (WGBS), or mass spectrometry (MS) were developed to obtain epigenetic data. This leads to the need for robust tools to analyze and interpret these high-throughput data. With the development of bioinformatics tools, several complex interactions between DNA methylation and chromatin modification were clarified to help researchers control gene expression. Moreover, data science, and information technology, especially machine learning and deep learning, have revolutionized the study of epigenetics in cancer, providing powerful tools to integrate both genetic and epigenetic data, as well as clinical/para-clinical characteristics to enhance the accuracy of cancer diagnosis and treatment strategies. In this study, we will provide an overview of epigenetics' role in cancer, and more importantly, an update on the application of bioinformatics and data science in the epigenetic field for cancers. Integrating epigenetic data with other data like omics and clinical data with the help of bioinformatics and data science is an emerging direction for deciphering the epigenetic landscape of cancer and identifying potential therapeutic targets.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"400 ","pages":"157-172"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy in endothelial cells: A gatekeeper of immune cell trafficking and function. 内皮细胞的自噬：免疫细胞运输和功能的守门人。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2026-02-24 DOI: 10.1016/bs.ircmb.2026.02.001

Guillermo Marcos-Zapatero, Dafne García-Mateos, Irene Carriles-Moar, Natalia Reglero-Real

{"title":"Autophagy in endothelial cells: A gatekeeper of immune cell trafficking and function.","authors":"Guillermo Marcos-Zapatero, Dafne García-Mateos, Irene Carriles-Moar, Natalia Reglero-Real","doi":"10.1016/bs.ircmb.2026.02.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2026.02.001","url":null,"abstract":"Endothelial cells (ECs) are increasingly recognised as dynamic regulators of immunity rather than passive vascular barriers. By integrating inflammatory, metabolic, and mechanical cues, ECs actively shape leukocyte trafficking and determine inflammatory outcomes. Autophagy, a conserved lysosomal degradation pathway essential for cellular homeostasis, has emerged as a key determinant of endothelial function in health and disease. Recent work identifies EC autophagy as a context-dependent determinant of leukocyte trafficking, vascular inflammation, antigen presentation, and endothelial phagocytic capacity. Beyond controlling immune cell recruitment, EC autophagy intersects with xenophagy, efferocytosis, and vascular ageing, highlighting its broad immunomodulatory potential. In this review, we synthesise current evidence defining how autophagy within ECs regulates immune responses in a tissue-specific manner during acute and chronic inflammation. Collectively, these insights position EC autophagy as a central integrator of vascular and immune homeostasis and underscore its potential as a therapeutic target in chronic inflammatory and ageing-associated diseases.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"406 ","pages":"131-163"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-33: A new frontier in cancer immunotherapy. 白细胞介素-33：肿瘤免疫治疗的新前沿。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-04-07 DOI: 10.1016/bs.ircmb.2025.03.002

Amrita Kaur, Kaelie Bittorf, Ayan Chanda, Megan Kinzel, Hobin Seo, Huiyang Yu, Qiutong Huang, Gabrielle T Belz, Pinaki Bose, Nicolas Jacquelot

{"title":"Interleukin-33: A new frontier in cancer immunotherapy.","authors":"Amrita Kaur, Kaelie Bittorf, Ayan Chanda, Megan Kinzel, Hobin Seo, Huiyang Yu, Qiutong Huang, Gabrielle T Belz, Pinaki Bose, Nicolas Jacquelot","doi":"10.1016/bs.ircmb.2025.03.002","DOIUrl":"10.1016/bs.ircmb.2025.03.002","url":null,"abstract":"Interleukin (IL)-33 is a member of the IL-1 cytokine family that is involved in critical physiological functions. IL-33 is constitutively expressed in the nucleus of many cell types and participates in gene regulation. However, during inflammation, IL-33 is released by cells to promote an immune response and favor tissue repair. Often referred to as an 'alarmin' due to its involvement in the early stages of inflammation, IL-33 binds to its receptor ST2 and directly modulates the activity of various immune and non-immune cell subsets. The role of the IL-33/ST2 axis has been extensively studied in reference to various inflammatory diseases and allergic responses. In cancer, this axis plays a dual role, driving pro-tumorigenic and anti-tumorigenic responses depending on the cancer type, disease stage and tumor microenvironment composition. These observations highlight the pleiotropic role exhibited by this axis in tumors. Efforts are currently being made to better understand its underlying mechanisms with the aim to exploit its therapeutic potential, alone or in combination with other anti-cancer immunotherapies. In this review, we discuss the physiological relevance of IL-33 in the context of inflammation, tumor development and progression, its impact on the tumor microenvironment, and its future application in cancer immunotherapy. Advanced understanding of the knowledge gaps and nuances pertaining to the IL-33/ST2 axis will enable the formulation of better treatments to improve patient outcomes.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"401 ","pages":"47-111"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic insights of microRNAs: Pioneering cancer detection via advanced biosensors. 微rna的表观遗传学见解：通过先进的生物传感器进行癌症检测的先驱。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-02-25 DOI: 10.1016/bs.ircmb.2025.01.008

P P Ashikha Shirin Usman, Durairaj Sekar

{"title":"Epigenetic insights of microRNAs: Pioneering cancer detection via advanced biosensors.","authors":"P P Ashikha Shirin Usman, Durairaj Sekar","doi":"10.1016/bs.ircmb.2025.01.008","DOIUrl":"10.1016/bs.ircmb.2025.01.008","url":null,"abstract":"The epigenetic landscape of cancer reveals how microRNAs (miRNAs) regulate gene expression through epigenetic mechanisms, alongside advancements in miRNA-based biosensor technology for early detection. Epigenetics, which studies heritable gene function changes without altering DNA sequences, has transformed our understanding of cancer by highlighting the complex interaction between genetics and environment. Key mechanisms such as DNA methylation, histone modification, and chromatin remodelling shape gene expression and cellular identity, with dysregulation in these processes often marking cancer development. Within this framework, miRNAs act as crucial epigenetic regulators, influencing gene expression post-transcriptionally and functioning as either oncogenes (oncomiRs) or tumour suppressors. miRNAs interact with epigenetic modifiers like histone deacetylases (HDACs) and DNA methyltransferases (DNMTs), creating regulatory networks that affect cancer cell behaviours such as proliferation, differentiation, and apoptosis. To apply these molecular insights, the chapter reviews innovations in miRNA-targeting biosensors. Electrochemical and photoelectrochemical biosensors, enhanced with nanotechnology, are designed to detect miRNAs at ultra-low concentrations in biological fluids, addressing limitations of conventional cancer diagnostics. These biosensors offer high sensitivity, specificity, and point-of-care potential, with benefits such as rapid response, cost-efficiency, and miniaturization. Case studies showcase miRNA-based biosensors targeting cancer-related miRNAs, underscoring their promise in early cancer detection and monitoring. By bridging epigenetics, miRNA regulation, and biosensor technology, these emerging diagnostic tools offer new possibilities for improving cancer diagnosis and patient outcomes.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"400 ","pages":"31-62"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycophagy: A selective autophagy pathway for glycogen degradation. 糖吞噬：糖原降解的选择性自噬途径。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-09-20 DOI: 10.1016/bs.ircmb.2025.08.014

Pascual Sanz, Maria Adelaida Garcia-Gimeno

引用次数: 0

Bioink-based 3D bioprinting: Paving the path for regenerative medicine. 基于生物墨水的3D生物打印：为再生医学铺平道路。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-12-18 DOI: 10.1016/bs.ircmb.2025.12.007

Dhruvi Dipakbhai Patel, Shalu Jha, Khushboo Virpankar, Meher Mounika, Ratnesh Singh, Vishal Nayak, Sneha Joshi, Anand Krishna Tiwari, Juni Banerjee, Shuvomoy Banerjee

{"title":"Bioink-based 3D bioprinting: Paving the path for regenerative medicine.","authors":"Dhruvi Dipakbhai Patel, Shalu Jha, Khushboo Virpankar, Meher Mounika, Ratnesh Singh, Vishal Nayak, Sneha Joshi, Anand Krishna Tiwari, Juni Banerjee, Shuvomoy Banerjee","doi":"10.1016/bs.ircmb.2025.12.007","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2025.12.007","url":null,"abstract":"Three-dimensional (3D) bioprinting has come a long way to have emerged as a transformative technology in bio-fabrication. Bioinks with specific attributes of cellular compatibility, mechanical strength, printability, and biodegradability remain crucial factors and yet a critical challenge. More growth in bioinks is happening with 4D bioprinting due to new developments in supramolecular hydrogels and both naturally and artificially made polymers. iPSCs, organ-on-chip technologies, and microfluidics allow scientists to produce sensitive tissue used for drug therapy and diagnosing diseases. Extrusion, inkjet, and stereolithographic printing let 3D bio-printers mix several materials, preserve cells, and create highly detailed prints. Despite the differences and similarities of AI and automation, they can both be valuable for ensuring quality control. Concerns that limit the clinical use of 3D bioprinting involve regulations, the uneven consistency of bioink, and the importance of ensuring long-term security. It is essential to develop platforms for bioprinting that are scalable, reasonably low-cost, and GMP-compliant and to maintain close collaboration among different fields to achieve all that personalized regenerative medicine and clinical care for cancer, heart disease, neurological diseases, and similar illnesses can offer.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"405 ","pages":"187-217"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0