Chemokine receptors and their ligands in breast cancer: The key roles in progression and metastasis.

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Julio Valdivia-Silva,Alberto Chinney-Herrera
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引用次数: 0

Abstract

Chemokines and their receptors are a family of chemotactic cytokines with important functions in the immune response in both health and disease. Their known physiological roles such as the regulation of leukocyte trafficking and the development of immune organs generated great interest when it was found that they were also related to the control of early and late inflammatory stages in the tumor microenvironment. In fact, in breast cancer, an imbalance in the synthesis of chemokines and/or in the expression of their receptors was attributed to be involved in the regulation of disease progression, including invasion and metastasis. Research in this area is progressing rapidly and the development of new agents based on chemokine and chemokine receptor antagonists are emerging as attractive alternative strategies. This chapter provides a snapshot of the different functions reported for chemokines and their receptors with respect to the potential to regulate breast cancer progression.
乳腺癌中的趋化因子受体及其配体:乳腺癌进展和转移中的关键作用。
趋化因子及其受体是一系列趋化细胞因子,在健康和疾病的免疫反应中具有重要功能。当人们发现趋化因子及其受体还与肿瘤微环境中早期和晚期炎症阶段的控制有关时,它们已知的生理作用(如调节白细胞的迁移和免疫器官的发育)引起了人们的极大兴趣。事实上,在乳腺癌中,趋化因子合成和/或其受体表达的失衡被认为参与了疾病进展的调控,包括侵袭和转移。这一领域的研究进展迅速,基于趋化因子和趋化因子受体拮抗剂的新药开发正在成为具有吸引力的替代策略。本章简要介绍了已报道的趋化因子及其受体在调控乳腺癌进展方面的不同功能。
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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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