International review of cell and molecular biology最新文献_第10页

Dual impact of radiation therapy on tumor-targeting immune responses. 放射治疗对肿瘤靶向免疫反应的双重影响。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/S1937-6448(23)00114-4

Céline Mirjolet, Jérémy Baude, Lorenzo Galluzzi

引用次数: 0

Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sites. 癌症中的超级增强子景观重新布线:远端位点的表观遗传控制。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.03.013

Eros Di Giorgio, Roberta Benetti, Emanuela Kerschbamer, Luigi Xodo, Claudio Brancolini

引用次数: 0

Models to study CTCs and CTC culture methods. 研究CTC和CTC培养方法的模型。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-08-03 DOI: 10.1016/bs.ircmb.2023.07.007

Cristóbal Fernández-Santiago, Rafael López-López, Roberto Piñeiro

{"title":"Models to study CTCs and CTC culture methods.","authors":"Cristóbal Fernández-Santiago, Rafael López-López, Roberto Piñeiro","doi":"10.1016/bs.ircmb.2023.07.007","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.07.007","url":null,"abstract":"The vast majority of cancer-related deaths are due to the presence of disseminated disease. Understanding the metastatic process is key to achieving a reduction in cancer mortality. Particularly, there is a need to understand the molecular mechanisms that drive cancer metastasis, which will allow the identification of curative treatments for metastatic cancers. Liquid biopsies have arisen as a minimally invasive approach to gain insights into the biology of metastasis. Circulating tumour cells (CTCs), shed to the circulation from the primary tumour or metastatic lesions, are a key component of liquid biopsy. As metastatic precursors, CTCs hold the potential to unravel the mechanisms involved in metastasis formation as well as new therapeutic strategies for treating metastatic disease. However, the complex biology of CTCs together with their low frequency in circulation are factors hampering an in-depth mechanistic investigation of the metastatic process. To overcome these problems, CTC-derived models, including CTC-derived xenograft (CDX) and CTC-derived ex vivo cultures, in combination with more traditional in vivo models of metastasis, have emerged as powerful tools to investigate the biological features of CTCs facilitating cancer metastasis and uncover new therapeutic opportunities. In this chapter, we provide an up to date view of the diverse models used in different cancers to study the biology of CTCs, and of the methods developed for CTC culture and expansion, in vivo and ex vivo. We also report some of the main challenges and limitations that these models are facing.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"381 ","pages":"57-98"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41101107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncolytic viruses in hematological malignancies: hijacking disease biology and fostering new promises for immune and cell-based therapies. 恶性血液病中的溶瘤病毒:劫持疾病生物学并促进免疫和细胞治疗的新前景。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.05.001

Mário Sousa-Pimenta, Ângelo Martins, Vera Machado

{"title":"Oncolytic viruses in hematological malignancies: hijacking disease biology and fostering new promises for immune and cell-based therapies.","authors":"Mário Sousa-Pimenta, Ângelo Martins, Vera Machado","doi":"10.1016/bs.ircmb.2023.05.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.05.001","url":null,"abstract":"The increased tropism for malignant cells of some viruses has been highlighted in recent studies, prompting their use as a strategy to modify the transcriptional profile of those cells, while sparing the healthy ones. Likewise, they have been recognized as players modulating microenvironmental immunity, namely through an increase in antigen-presenting, natural-killer, and T CD8+ cytotoxic cells by a cross-priming mechanism elicited by tumor-associated antigens. The immunomodulatory role of the oncolytic virus seems relevant in hematological malignancies, which may relapse as a result of a proliferative burst elicited by an external stimulus in progenitor or neoplastic stem cells. By reprogramming the host cells and the surrounding environment, the potential of virotherapy ranges from the promise to eradicate the minimal measurable disease (in acute leukemia, for example), to the ex vivo purging of malignant progenitor cells in the setting of autologous bone marrow transplantation. In this review, we analyze the recent advances in virotherapy in hematological malignancies, either when administered alone or together with chemotherapeutic agents or other immunomodulators.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"379 ","pages":"189-219"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9948624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation of epithelial-mesenchymal transition during cancer development. 肿瘤发生过程中上皮-间质转化的表观遗传调控。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.05.007

Sunisa Yoodee, Visith Thongboonkerd

引用次数: 0

Epigenetic inhibitors and their role in cancer therapy. 表观遗传抑制剂及其在癌症治疗中的作用。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.04.005

Nouha Abdelaziz, Lubna Therachiyil, Hana Q Sadida, Ateeque Mohamed Ali, Omar S Khan, Mayank Singh, Abdul Q Khan, Ammira S Al-Shabeeb Akil, Ajaz A Bhat, Shahab Uddin

引用次数: 0

Opportunities and challenges of low-dose radiation to enable immunotherapy efficacy. 低剂量辐射促进免疫治疗疗效的机遇和挑战。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.03.010

Katiuska Passelli, David Repáraz, Fernanda G Herrera

引用次数: 0

Recent advances in targeting myeloid-derived suppressor cells and their applications to radiotherapy. 靶向髓源性抑制细胞及其在放射治疗中的应用研究进展。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.03.007

Zi-Zhan Li, Jing-Yu He, Qiuji Wu, Bing Liu, Lin-Lin Bu

{"title":"Recent advances in targeting myeloid-derived suppressor cells and their applications to radiotherapy.","authors":"Zi-Zhan Li, Jing-Yu He, Qiuji Wu, Bing Liu, Lin-Lin Bu","doi":"10.1016/bs.ircmb.2023.03.007","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.03.007","url":null,"abstract":"Myeloid-derived suppressor cells (MDSCs) are a group of heterogenous immature myeloid cells with potent immune suppressive properties that not only constrain anti-tumor immune activation and functions, promote tumor progression, but also contribute to treatment resistance and tumor relapse. Targeting MDSCs may be a promising new cancer treatment method, but there is still a problem of low treatment efficiency. Combined application with radiotherapy may be a potential method to solve this problem. Drug delivery systems (DDSs) provide more efficient targeted drug delivery capability and can reduce the toxicity and side effects of drugs. Recent advance in DDSs targeting development, recruitment, differentiation, and elimination of MDSCs have shown promising effect in reversing immune inhibition and in overcoming radiotherapy resistance. In this review, we systematically summarized DDSs applied to target MDSCs for the first time, and classified and discussed it according to its different mechanisms of action. In addition, this paper also reviewed the biological characteristics of MDSCs and their role in the initiation, progression, and metastasis of cancer. Moreover, this review also summarizes the role of DDSs targeting MDSCs in radiosensitization. Finally, the future development of DDSs targeting MDSCs is also prospected.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"378 ","pages":"233-264"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9816039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Relationship between the tumor microenvironment and the efficacy of the combination of radiotherapy and immunotherapy. 肿瘤微环境与放疗和免疫疗法联合疗效之间的关系。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-04-17 DOI: 10.1016/bs.ircmb.2023.03.006

Chang Su, Jonathon E Himes, David G Kirsch

引用次数: 0

Combining radiotherapy and NK cell-based therapies: The time has come. 放疗与NK细胞治疗相结合:时机已经成熟。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.02.003

Jérémy Baude, Emeric Limagne, Riad Ladjohounlou, Céline Mirjolet

{"title":"Combining radiotherapy and NK cell-based therapies: The time has come.","authors":"Jérémy Baude, Emeric Limagne, Riad Ladjohounlou, Céline Mirjolet","doi":"10.1016/bs.ircmb.2023.02.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.02.003","url":null,"abstract":"Natural killer (NK) cells are innate lymphoid cells that play an essential role in the anti-tumor response through immunosurveillance, multiple mechanisms of cytotoxicity and the synthesis of cytokines modulating the immune tumor microenvironment (TME). After the dramatic advances in immunotherapy targeting T cells including the success of checkpoint inhibitors or autologous chimeric antigen receptor (CAR) expressing T cells in clinical practice, NK cells have gained growing interest for the development of new therapies. Although NK cells have shown promising responses in leukemia patients, the effects of NK-targeted therapies are currently limited in the treatment of solid tumors. Thus, radiotherapy could provide a valuable solution to improve treatments targeting NK cells. Indeed, ionizing radiations represent a powerful immuno-modulator that can either induce a pro-inflammatory and anti-tumor TME, or conversely lead to immunosuppression of effector immune cells in favor of tumor growth and therapeutic escape, depending on how it is delivered and tumor models. However, the effects of ionizing radiation on NK cells are only partially understood. Therefore, we review the effects of radiotherapy on the NK cell-mediated anti-tumor response, and propose potential strategies to reinvigorate NK cells by combining radiotherapy with NK cell-targeted therapies.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"378 ","pages":"31-60"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9816040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1