癌症中的超级增强子景观重新布线:远端位点的表观遗传控制。

3区生物学 Q1 Biochemistry, Genetics and Molecular Biology

International review of cell and molecular biology Pub Date : 2023-01-01 DOI:10.1016/bs.ircmb.2023.03.013

Eros Di Giorgio, Roberta Benetti, Emanuela Kerschbamer, Luigi Xodo, Claudio Brancolini

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引用次数: 0

摘要

超级增强子作为基因表达层次控制的顶层元素而进化。它们是控制干性、分化或适应性反应的信号通路的重要末端采集者。许多表观遗传调控集中在这些区域，毫不奇怪，在肿瘤发生过程中，各种改变可以解释它们的功能障碍。超级增强子正在成为维持癌细胞侵袭性的异常基因表达景观的关键驱动因素。在这篇综述中，我们将描述和讨论超级增强子的结构，它们的表观遗传调控，以及在癌症中影响它们功能的主要变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sites.

Super-enhancers evolve as elements at the top of the hierarchical control of gene expression. They are important end-gatherers of signaling pathways that control stemness, differentiation or adaptive responses. Many epigenetic regulations focus on these regions, and not surprisingly, during the process of tumorigenesis, various alterations can account for their dysfunction. Super-enhancers are emerging as key drivers of the aberrant gene expression landscape that sustain the aggressiveness of cancer cells. In this review, we will describe and discuss about the structure of super-enhancers, their epigenetic regulation, and the major changes affecting their functionality in cancer.

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来源期刊

International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY

CiteScore

7.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.