International review of cell and molecular biology最新文献_第9页

Myeloid-derived suppressor cells: A new emerging player in endometriosis. 髓源性抑制细胞:子宫内膜异位症的新参与者。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2022.11.004

Tao Zhang, Ying He, Gene Chi Wai Man, Yang Ding, Chi Chiu Wang, Jacqueline Pui Wah Chung

{"title":"Myeloid-derived suppressor cells: A new emerging player in endometriosis.","authors":"Tao Zhang, Ying He, Gene Chi Wai Man, Yang Ding, Chi Chiu Wang, Jacqueline Pui Wah Chung","doi":"10.1016/bs.ircmb.2022.11.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2022.11.004","url":null,"abstract":"Endometriosis is a common gynecological disorder defined by the presence of endometrial tissue outside the uterus. This is commonly associated with chronic pelvic pain, infertility, and dysmenorrhea, which occurs in approximately 10% of women of reproductive age. Although the exact mechanism remains uncertain, it has been widely accepted to be an estrogen-dependent and inflammatory disease. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immune cells with immunosuppressive capacity and non-immunological functions. They have been found to be aggressively involved in the pathologies of various disorders. In regards to tumors, the functions of MDSCs have been profoundly shown to inhibit tumor immune response and to promote angiogenesis, tumor metastasis, fibrosis, and epithelial-mesenchymal transition (EMT). In recent years, the elevation of MDSCs in endometriosis was reported by several studies that provoke the assumption that MDSCs might exert similar roles to promote the development of endometriosis. Such that, precision treatments targeting MDSCs might be a promising direction for future study. Herein, we will review the research progress of MDSCs in endometriosis and its potential relevance to the pathogenesis, progression, and therapeutics strategy of endometriosis.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"375 ","pages":"191-220"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9506634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Radio-induced lymphopenia in the era of anti-cancer immunotherapy. 抗癌免疫治疗时代的放射性淋巴细胞减少症。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.03.002

François de Kermenguy, Lydia Meziani, Michele Mondini, Céline Clémenson, Daphné Morel, Eric Deutsch, Charlotte Robert

引用次数: 1

Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer. 癌症早期转移性循环肿瘤细胞临床研究的最新进展。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-09-01 DOI: 10.1016/bs.ircmb.2023.07.005

Laura S Munoz-Arcos, Eleonora Nicolò, Mara S Serafini, Lorenzo Gerratana, Carolina Reduzzi, Massimo Cristofanilli

引用次数: 0

Attaching and effacing pathogens modulate host mitochondrial structure and function. 病原体的附着和脱落会调节宿主线粒体的结构和功能。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-04-03 DOI: 10.1016/bs.ircmb.2023.03.001

Anusha Harishankar, V K Viswanathan

{"title":"Attaching and effacing pathogens modulate host mitochondrial structure and function.","authors":"Anusha Harishankar, V K Viswanathan","doi":"10.1016/bs.ircmb.2023.03.001","DOIUrl":"10.1016/bs.ircmb.2023.03.001","url":null,"abstract":"Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) are human enteric pathogens that contribute significantly to morbidity and mortality worldwide. These extracellular pathogens attach intimately to intestinal epithelial cells and cause signature lesions by effacing the brush border microvilli, a property they share with other \"attaching and effacing\" (A/E) bacteria, including the murine pathogen Citrobacter rodentium. A/E pathogens use a specialized apparatus called a type III secretion system (T3SS) to deliver specific proteins directly into the host cytosol and modify host cell behavior. The T3SS is essential for colonization and pathogenesis, and mutants lacking this apparatus fail to cause disease. Thus, deciphering effector-induced host cell modifications is critical for understanding A/E bacterial pathogenesis. Several of the ∼20-45 effector proteins delivered into the host cell modify disparate mitochondrial properties, some via direct interactions with the mitochondria and/or mitochondrial proteins. In vitro studies have uncovered the mechanistic basis for the actions of some of these effectors, including their mitochondrial targeting, interaction partners, and consequent impacts on mitochondrial morphology, oxidative phosphorylation and ROS production, disruption of membrane potential, and intrinsic apoptosis. In vivo studies, mostly relying on the C. rodentium/mouse model, have been used to validate a subset of the in vitro observations; additionally, animal studies reveal broad changes to intestinal physiology that are likely accompanied by mitochondrial alterations, but the mechanistic underpinnings remain undefined. This chapter provides an overview of A/E pathogen-induced host alterations and pathogenesis, specifically focusing on mitochondria-targeted effects.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"377 ","pages":"65-86"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10119158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay between selective types of (macro)autophagy: Mitophagy and xenophagy. 选择性(宏观)自噬类型之间的相互作用:有丝自噬和异种自噬。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2022.10.003

Teresa Rubio-Tomás, Aggeliki Sotiriou, Nektarios Tavernarakis

引用次数: 3

Novel insights into DNA methylation-based epigenetic regulation of breast tumor angiogenesis. 基于DNA甲基化的乳腺肿瘤血管生成表观遗传调控的新见解。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.04.002

Sharath Mohan Bhat, Palla Ranga Prasad, Manjunath B Joshi

{"title":"Novel insights into DNA methylation-based epigenetic regulation of breast tumor angiogenesis.","authors":"Sharath Mohan Bhat, Palla Ranga Prasad, Manjunath B Joshi","doi":"10.1016/bs.ircmb.2023.04.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.04.002","url":null,"abstract":"Breast tumors are highly vascularized and dependent on angiogenesis for growth, progression and metastasis. Like other solid tumors, vasculature in breast tumors also display leaky and tortuous phenotype and hence inhibit immune cell infiltration, show reduced efficacy to anticancer drugs and radiotherapy. Epigenetic reprogramming including significant alterations in DNA methylation in tumor and stromal cells generate an imbalance in expression of pro- and anti-angiogenic factors and subsequently lead to disordered angiogenesis. Hence, understanding DNA methylation-based regulation of angiogenesis in breast tumors may open new avenues for designing therapeutic targets. Our present review manuscript summarized contemporary knowledge of influence of DNA methylation in regulating angiogenesis. Further, we identified novel set of pro-angiogenic genes enriched in endothelial cells which are coregulated with DNMT isoforms in breast tumors and harboring CpG islands. Our analysis revealed promoters of pro-angiogenic genes were hypomethylated and anti-angiogenic genes were hypermethylated in tumors and further reflected on their expression patterns. Interestingly, promoter DNA methylation intensities of novel set of pro-angiogenic genes significantly correlated to patient survival outcome.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"380 ","pages":"63-96"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10159657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of radiation therapy on healthy tissues. 放射治疗对健康组织的影响。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2022.11.006

Cyrus Chargari, Elie Rassy, Carole Helissey, Samir Achkar, Sabine Francois, Eric Deutsch

{"title":"Impact of radiation therapy on healthy tissues.","authors":"Cyrus Chargari, Elie Rassy, Carole Helissey, Samir Achkar, Sabine Francois, Eric Deutsch","doi":"10.1016/bs.ircmb.2022.11.006","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2022.11.006","url":null,"abstract":"Radiation therapy has a fundamental role in the management of cancers. However, despite a constant improvement in radiotherapy techniques, the issue of radiation-induced side effects remains clinically relevant. Mechanisms of acute toxicity and late fibrosis are therefore important topics for translational research to improve the quality of life of patients treated with ionizing radiations. Tissue changes observed after radiotherapy are consequences of complex pathophysiology, involving macrophage activation, cytokine cascade, fibrotic changes, vascularization disorders, hypoxia, tissue destruction and subsequent chronic wound healing. Moreover, numerous data show the impact of these changes in the irradiated stroma on the oncogenic process, with interplays between tumor radiation response and pathways involved in the fibrotic process. The mechanisms of radiation-induced normal tissue inflammation are reviewed, with a focus on the impact of the inflammatory process on the onset of treatment-related toxicities and the oncogenic process. Possible targets for pharmacomodulation are also discussed.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"376 ","pages":"69-98"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9452264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis. 解决非常规循环肿瘤细胞的不确定性：上皮-间充质转化、细胞融合和胞嘧啶。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-08-08 DOI: 10.1016/bs.ircmb.2023.07.004

Giulia Gallerani, Tania Rossi, Manuela Ferracin, Massimiliano Bonafè

引用次数: 0

Epigenetic regulation of cancer. 癌症的表观遗传调控。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-08-30 DOI: 10.1016/S1937-6448(23)00145-4

Sheila Spada, Lorenzo Galluzzi

引用次数: 0

The various functions and phenotypes of macrophages are also reflected in their responses to irradiation: A current overview. 巨噬细胞的各种功能和表型也反映在它们对辐照的反应中:当前概述。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.01.002

Lisa Deloch, Michael Rückert, Thomas Weissmann, Sebastian Lettmaier, Eva Titova, Teresa Wolff, Felix Weinrich, Rainer Fietkau, Udo S Gaipl

{"title":"The various functions and phenotypes of macrophages are also reflected in their responses to irradiation: A current overview.","authors":"Lisa Deloch, Michael Rückert, Thomas Weissmann, Sebastian Lettmaier, Eva Titova, Teresa Wolff, Felix Weinrich, Rainer Fietkau, Udo S Gaipl","doi":"10.1016/bs.ircmb.2023.01.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.01.002","url":null,"abstract":"Macrophages are a vital part of the innate immune system that are involved in healthy biological processes but also in disease modulation and response to therapy. Ionizing radiation is commonly used in the treatment of cancer and, in a lower dose range, as additive therapy for inflammatory diseases. In general, lower doses of ionizing radiation are known to induce rather anti-inflammatory responses, while higher doses are utilized in cancer treatment where they result, next to tumor control, in rather inflammatory responses. Most experiments that have been carried out in ex vivo on macrophages find this to be true, however in vivo, tumor-associated macrophages, for example, show a contradictory response to the respective dose-range. While some knowledge in radiation-induced modulations of macrophages has been collected, many of the underlying mechanisms remain unclear. Due to their pivotal role in the human body, however, they are a great target in therapy and could potentially aid in better treatment outcome. We therefore summarized the current knowledge of macrophage mediated radiation responses.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"376 ","pages":"99-120"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9452265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0