International review of cell and molecular biology最新文献_第9页

Epigenetic regulation of epithelial-mesenchymal transition during cancer development. 肿瘤发生过程中上皮-间质转化的表观遗传调控。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.05.007

Sunisa Yoodee, Visith Thongboonkerd

引用次数: 0

Epigenetic inhibitors and their role in cancer therapy. 表观遗传抑制剂及其在癌症治疗中的作用。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.04.005

Nouha Abdelaziz, Lubna Therachiyil, Hana Q Sadida, Ateeque Mohamed Ali, Omar S Khan, Mayank Singh, Abdul Q Khan, Ammira S Al-Shabeeb Akil, Ajaz A Bhat, Shahab Uddin

引用次数: 0

Opportunities and challenges of low-dose radiation to enable immunotherapy efficacy. 低剂量辐射促进免疫治疗疗效的机遇和挑战。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.03.010

Katiuska Passelli, David Repáraz, Fernanda G Herrera

引用次数: 0

Recent advances in targeting myeloid-derived suppressor cells and their applications to radiotherapy. 靶向髓源性抑制细胞及其在放射治疗中的应用研究进展。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.03.007

Zi-Zhan Li, Jing-Yu He, Qiuji Wu, Bing Liu, Lin-Lin Bu

{"title":"Recent advances in targeting myeloid-derived suppressor cells and their applications to radiotherapy.","authors":"Zi-Zhan Li, Jing-Yu He, Qiuji Wu, Bing Liu, Lin-Lin Bu","doi":"10.1016/bs.ircmb.2023.03.007","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.03.007","url":null,"abstract":"Myeloid-derived suppressor cells (MDSCs) are a group of heterogenous immature myeloid cells with potent immune suppressive properties that not only constrain anti-tumor immune activation and functions, promote tumor progression, but also contribute to treatment resistance and tumor relapse. Targeting MDSCs may be a promising new cancer treatment method, but there is still a problem of low treatment efficiency. Combined application with radiotherapy may be a potential method to solve this problem. Drug delivery systems (DDSs) provide more efficient targeted drug delivery capability and can reduce the toxicity and side effects of drugs. Recent advance in DDSs targeting development, recruitment, differentiation, and elimination of MDSCs have shown promising effect in reversing immune inhibition and in overcoming radiotherapy resistance. In this review, we systematically summarized DDSs applied to target MDSCs for the first time, and classified and discussed it according to its different mechanisms of action. In addition, this paper also reviewed the biological characteristics of MDSCs and their role in the initiation, progression, and metastasis of cancer. Moreover, this review also summarizes the role of DDSs targeting MDSCs in radiosensitization. Finally, the future development of DDSs targeting MDSCs is also prospected.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"378 ","pages":"233-264"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9816039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Relationship between the tumor microenvironment and the efficacy of the combination of radiotherapy and immunotherapy. 肿瘤微环境与放疗和免疫疗法联合疗效之间的关系。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-04-17 DOI: 10.1016/bs.ircmb.2023.03.006

Chang Su, Jonathon E Himes, David G Kirsch

引用次数: 0

Combining radiotherapy and NK cell-based therapies: The time has come. 放疗与NK细胞治疗相结合:时机已经成熟。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.02.003

Jérémy Baude, Emeric Limagne, Riad Ladjohounlou, Céline Mirjolet

{"title":"Combining radiotherapy and NK cell-based therapies: The time has come.","authors":"Jérémy Baude, Emeric Limagne, Riad Ladjohounlou, Céline Mirjolet","doi":"10.1016/bs.ircmb.2023.02.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.02.003","url":null,"abstract":"Natural killer (NK) cells are innate lymphoid cells that play an essential role in the anti-tumor response through immunosurveillance, multiple mechanisms of cytotoxicity and the synthesis of cytokines modulating the immune tumor microenvironment (TME). After the dramatic advances in immunotherapy targeting T cells including the success of checkpoint inhibitors or autologous chimeric antigen receptor (CAR) expressing T cells in clinical practice, NK cells have gained growing interest for the development of new therapies. Although NK cells have shown promising responses in leukemia patients, the effects of NK-targeted therapies are currently limited in the treatment of solid tumors. Thus, radiotherapy could provide a valuable solution to improve treatments targeting NK cells. Indeed, ionizing radiations represent a powerful immuno-modulator that can either induce a pro-inflammatory and anti-tumor TME, or conversely lead to immunosuppression of effector immune cells in favor of tumor growth and therapeutic escape, depending on how it is delivered and tumor models. However, the effects of ionizing radiation on NK cells are only partially understood. Therefore, we review the effects of radiotherapy on the NK cell-mediated anti-tumor response, and propose potential strategies to reinvigorate NK cells by combining radiotherapy with NK cell-targeted therapies.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"378 ","pages":"31-60"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9816040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Radiation therapy-activated nanoparticle and immunotherapy: The next milestone in oncology? 放射治疗激活纳米粒子和免疫治疗:肿瘤学的下一个里程碑?

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.03.005

Sébastien Penninckx, Juliette Thariat, Céline Mirjolet

{"title":"Radiation therapy-activated nanoparticle and immunotherapy: The next milestone in oncology?","authors":"Sébastien Penninckx, Juliette Thariat, Céline Mirjolet","doi":"10.1016/bs.ircmb.2023.03.005","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.03.005","url":null,"abstract":"Radiotherapy (RT) is a fundamental treatment at the locoregional or oligometastatic stages of cancer. In various tumors, RT effects may be optimized using synergistic combinations that enhance tumor response. Innovative strategies have been designed that explore the radiation mechanisms, at the physical, chemical and biological levels, to propose precision RT approaches. They consist in combining RT with immunotherapy to revert radiation immunosuppressive effects or to enhance radiation-induced immune defenses against the tumor to favor immunogenic cell death. Radiotherapy-activated nanoparticles are another innovation. By increasing radiation response in situ, nanoparticles improve tumor control locally, and can trigger systemic immune reactions that may be exploited to improve the systemic efficacy of RT. Strong clinical evidence of improved outcomes is now available for combinations of RT and immunotherapy on one hand and RT and nanoparticles on the other hand. The triple combination of RT, immunotherapy and nanoparticles is promising in terms of tolerance, local and systemic anti-tumor control. Yet, significant challenges remain to unravel the complexity of the multiscale mechanisms underlying response to this combination and their associated parameters. Such parameters include patient characteristics, tumor bulk and histology, radiation technique, energy, dose, fractionation, immunotherapy targets and predictive biomarkers, nanoparticle type, size, delivery (intratumoral/intravenous), distribution. The temporal combination is another critical parameter. The mechanisms of response of the combinatorial approaches are reviewed, with a focus on underlying mechanisms based on preclinical, translational and clinical studies. Opportunities for translation of current understanding into precision RT trials combined with immunotherapy and nanoparticles are also discussed.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"378 ","pages":"157-200"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9816043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Legionella and mitochondria, an intriguing relationship. 军团菌和线粒体，一个有趣的关系。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2022.10.001

Francisco Javier García-Rodríguez, Carmen Buchrieser, Pedro Escoll

引用次数: 0

The bacterial origin of mitochondria: Incorrect phylogenies and the importance of metabolic traits. 线粒体的细菌起源:不正确的系统发育和代谢特征的重要性。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2022.11.001

Mauro Degli Esposti

{"title":"The bacterial origin of mitochondria: Incorrect phylogenies and the importance of metabolic traits.","authors":"Mauro Degli Esposti","doi":"10.1016/bs.ircmb.2022.11.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2022.11.001","url":null,"abstract":"This article provides an updated review on the evolution of mitochondria from bacteria, which were likely related to extant alphaproteobacteria. Particular attention is given to the timeline of oxygen history on Earth and the entwined phases of eukaryotic evolution that produced the animals that still populate our planet. Mitochondria of early-branching unicellular eukaryotes and plants appear to retain partial or vestigial traits that were directly inherited from the alphaproteobacterial ancestors of the organelles. Most of such traits define the current aerobic physiology of mitochondria. Conversely, the anaerobic traits that would be essential in the syntrophic associations postulated for the evolution of eukaryotic cells are scantly present in extant alphaproteobacteria, and therefore cannot help defining from which bacterial lineage the ancestors of mitochondria originated. This question has recently been addressed quantitatively, reaching the novel conclusion that marine bacteria related to Iodidimonas may be the living relatives of protomitochondria. Additional evidence is presented that either support or does not contrast this novel view of the bacterial origin of mitochondria.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"374 ","pages":"1-35"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9822368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Oncolytic virotherapy in lung cancer. 肺癌的溶瘤病毒治疗。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.05.004

Estanislao Nistal-Villan, Sergio Rius-Rocabert, Francisco Llinares-Pinel

{"title":"Oncolytic virotherapy in lung cancer.","authors":"Estanislao Nistal-Villan, Sergio Rius-Rocabert, Francisco Llinares-Pinel","doi":"10.1016/bs.ircmb.2023.05.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.05.004","url":null,"abstract":"Lung tumors are one of the most aggressive threats affecting humans. Current therapeutic approaches have improved patients' survival; however, further efforts are required to increase effectiveness and protection against tumor relapse and metastasis. Immunotherapy presents an alternative to previous treatments that focuses on stimulating of the patient's immune system to destroy tumor cells. Viruses can be used as part of the immune therapeutic approach as agents that could selectively infect tumor cells, triggering an immune response against the infection and against the tumor cells. Some viruses have been selected for specifically infecting and destroying cancer cells, activating the immune response, enhancing access, amplifying the cytotoxicity against the tumor cells, and improving the long-term memory that can prevent tumor relapse. Oncolytic virotherapy can then be used as a strategy to target the destruction of transformed cells at the tumor site and act in locations distant from the primary targeted tumor site. Some of the current challenges in lung cancer treatment can be addressed using traditional therapies combined with oncolytic virotherapy. Defining the best combination, including the choice of the right settings will be at the next frontier in lung cancer treatment.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"379 ","pages":"221-239"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9946550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0