International review of cell and molecular biology最新文献_第9页

Emerging interactions between circadian rhythms and extracellular vesicles. 昼夜节律与细胞外囊泡之间的相互作用。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-11-23 DOI: 10.1016/bs.ircmb.2024.11.001

Jacob G Smith

{"title":"Emerging interactions between circadian rhythms and extracellular vesicles.","authors":"Jacob G Smith","doi":"10.1016/bs.ircmb.2024.11.001","DOIUrl":"10.1016/bs.ircmb.2024.11.001","url":null,"abstract":"Circadian rhythms are present across species, tuning internal processes to daily changes in the environment. Driven by genetically encoded circadian clocks present throughout the body, and modulated by external inputs, the circadian system is a key player in metabolic control. However, the molecular mediators underlying coordination between cells and tissues are not well known. Extracellular vesicles (EVs) have emerged over recent years as important players in cell-cell and organ-organ communication, however the influence of circadian rhythms on EVs is not yet understood. Research into this area is still scarce, yet already offers glimpses into the potential impact of circadian rhythms on EV biology. In this review, recent discoveries that reveal, directly or indirectly, a potential role for circadian rhythms in EV abundance, properties, cargo and signalling functions are first discussed. Next, the feedback of EV signalling on circadian clocks is considered. Last, unanswered questions regarding the interaction between circadian rhythms and EVs are examined alongside potential approaches to address them. Overall, the circadian impact on EV signalling is an exciting yet understudied aspect that warrants further investigation.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"393 ","pages":"73-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CTCs and liquid biopsies in patients with colorectal cancer. 结直肠癌患者的CTCs和液体活检。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-30 DOI: 10.1016/bs.ircmb.2024.10.001

Areeb Lutfi, Maaz Khan Afghan, Pashtoon Murtaza Kasi

引用次数: 0

Circadian rhythms in muscle health and diseases. 肌肉健康和疾病的昼夜节律。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-11-12 DOI: 10.1016/bs.ircmb.2024.10.002

Jeffrey J Kelu

{"title":"Circadian rhythms in muscle health and diseases.","authors":"Jeffrey J Kelu","doi":"10.1016/bs.ircmb.2024.10.002","DOIUrl":"10.1016/bs.ircmb.2024.10.002","url":null,"abstract":"All major life forms from bacteria to humans have internal clocks that regulate essential biological processes in a roughly 24-h cycle. In mammals, the central clock in the suprachiasmatic nucleus (SCN) is historically considered the top of a hierarchical organisation that dominates subordinate clocks in peripheral tissues and dictates the circadian behaviours of an organism. Recent studies, however, underscore the importance of the local circadian oscillators, such as the skeletal muscle clock, in regulating local metabolism and physiology. Studies in animal models show that the muscle peripheral clock per se is required for the expression of genes involved in glucose, lipid, and amino acid metabolism. Disruption of the muscle clock leads to glucose intolerance, insulin resistance, and alterations in muscle size and force. This highlights the vital role of the muscle clock in controlling muscle physiology and metabolism. In humans, a perturbation in the muscle circadian rhythms is seen in metabolic disorders such as type 2 diabetes, and muscle diseases such as dystrophies. Disruption of muscle metabolism is also seen when the internal rhythms are misaligned with the external rhythms (circadian misalignments) as in shift work. Understanding the mechanisms by which the muscle clock regulates circadian functions may help the development of new strategies, such as chronotherapy, to potentially prevent or treat muscle pathologies and maintain muscle health.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"393 ","pages":"45-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome-mediated immune modulation in tumor microenvironment. 肿瘤微环境中微生物介导的免疫调节。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-02-17 DOI: 10.1016/bs.ircmb.2024.12.012

John Richards, Eleanor L Davis, L Shakila, Janani Narayanan, Sadhna Aggarwal, Anshuman Mishra, Kranthi Kumar Madamchetty Venkata, Brandon K Walther, Abishai Dominic

{"title":"Microbiome-mediated immune modulation in tumor microenvironment.","authors":"John Richards, Eleanor L Davis, L Shakila, Janani Narayanan, Sadhna Aggarwal, Anshuman Mishra, Kranthi Kumar Madamchetty Venkata, Brandon K Walther, Abishai Dominic","doi":"10.1016/bs.ircmb.2024.12.012","DOIUrl":"10.1016/bs.ircmb.2024.12.012","url":null,"abstract":"This chapter explores the complex interplay between the tumor microenvironment (TME), the microbiome, and the immune system. It focuses on how microbes and their metabolites influence tumor development, progression, and the subsequent immune responses. The TME is a highly complex environment made up of cancer cells, immune cells, and the extracellular matrix, where immune cells can either inhibit or promote tumor growth depending on the context. The chapter highlights several key mechanisms of interaction, including microbial metabolites, the presentation of microbial antigens by tumor or immune cells, and the role of immune checkpoints, such as PD-L1, in modulating immune responses. Certain bacteria, viruses, and fungi can trigger immune responses that lead to the destruction of cancer cells, often through processes such as immunogenic cell death (ICD). Conversely, dysbiosis, or an imbalance in microbial communities, can create a pro-tumorigenic environment, aiding in tumor progression through chronic inflammation, immune suppression, and metabolic alterations. The chapter categorizes microbial interactions with cancer into three areas: microbes directly causing cancer (e.g., Epstein-Barr virus and HPV), cancers that induce infections (e.g., obstructing the respiratory or digestive systems), and tumors located in organs with natural microbiomes, such as the gastrointestinal tract. In addition to these mechanisms, the chapter also illuminates how microbial antigens can serve as potential identifiers and tools for cancer diagnosis and treatment, offering new avenues for personalized medicine. The insights gained from this exploration are important for advancing microbial-based therapies and improving the effectiveness of immunotherapies in cancer treatment.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"394 ","pages":"107-145"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

γδ T cells in Escherichia coli infection. 大肠杆菌感染中的γδ T细胞。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-09-13 DOI: 10.1016/bs.ircmb.2025.08.009

Carolina C Jancic

{"title":"γδ T cells in Escherichia coli infection.","authors":"Carolina C Jancic","doi":"10.1016/bs.ircmb.2025.08.009","DOIUrl":"10.1016/bs.ircmb.2025.08.009","url":null,"abstract":"gamma-delta (γδ) T cells reside in numerous tissues, recognize a vast array of antigens, and perform highly specialized functions. They have participated in antimicrobial and antitumor immunity, in modulation the immune responses and in tissue repair . γδ T cells are enriched in mucosa and skin; indeed, they are part of intraepithelial T lymphocytes, where they function as sentinels, promptly detecting infections, cellular stress, or tissue damage. It is well known that Escherichia coli (E. coli) is a common bacterium that can cause infections in humans. While many strains of E. coli are harmless and even beneficial to the host, some can cause gastroint estinal diseases or urinary tract infections, among other pathologies associated with the bacteria. The relationship between γδ T cells and E. coli remains relatively underexplored. However, gaining insight into this interaction is essential for understanding how γδ T cells recognize and respond to bacterial pathogens, a critical step in developing strategies for preventing and treating bacterial infections. This chapter explores the current knowledge about the role of human γδ T cells in infections caused by E. coli.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"398 ","pages":"151-184"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human T-cell receptor inborn errors of immunity shed light on the real-life role of γδ vs αβ T lymphocytes. 人类T细胞受体先天免疫错误揭示了γδ vs αβ T淋巴细胞的现实作用。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-09-23 DOI: 10.1016/bs.ircmb.2025.08.004

Ana V Marin, Daniel Chacon-Arguedas, Ivan Estevez-Benito, Angela Zarco-Cuadrillero, Miguel Muñoz-Ruiz, Jose R Regueiro

{"title":"Human T-cell receptor inborn errors of immunity shed light on the real-life role of γδ vs αβ T lymphocytes.","authors":"Ana V Marin, Daniel Chacon-Arguedas, Ivan Estevez-Benito, Angela Zarco-Cuadrillero, Miguel Muñoz-Ruiz, Jose R Regueiro","doi":"10.1016/bs.ircmb.2025.08.004","DOIUrl":"10.1016/bs.ircmb.2025.08.004","url":null,"abstract":"T lymphocytes are critical components of adaptive immunity. They are involved, together with other leucocytes, in defense against pathogens, including viruses, bacteria, fungi and parasites. Mature T cells include two subsets, αβ and γδ, depending on the variable T-cell receptor (TCR) expressed on their surface. αβ T cells, the largest subset in blood, are well characterized in terms of their functions in defense against infections. Their central role in protective immunity is dramatically clear in rare human inborn errors of immunity (IEI) causing selective αβ T-cell lymphopenia. Such defects frequently associate to early-onset health-threatening infections and autoimmunity (rather than cancer) and require hematopoietic stem cell transplantation for survival. γδ T-cell function, by contrast, is still not well understood, as we review here. Human IEI affecting several invariant and variable TCR chains (TCRIEI) have been reported, in some cases with a different impact in αβ vs γδ T-cell numbers. By comparing them, we show that clinical severity, as a proxy of importance for survival, associates with the absence of αβ T cells, irrespectively of γδ T-cell numbers. Several species and animal knock-out models which naturally or artificially lack γδ T cells support this contention. Thus, TCRIEI teach us that αβ T cells are crucial for defense against infections, whereas γδ T cells may have a comparatively marginal role in real-life human immunity.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"398 ","pages":"53-73"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation of cancer. 癌症的表观遗传调控。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 DOI: 10.1016/S1937-6448(25)00015-2

Lorenzo Galluzzi, Sheila Spada

引用次数: 0

Unraveling the role of γδ T cells in inflammatory bowel disease: Development and prevention strategies. 揭示γδ T细胞在炎症性肠病中的作用：发展和预防策略

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-03-20 DOI: 10.1016/bs.ircmb.2025.03.006

Ana María Múnera-Rodríguez, Camila Leiva-Castro, Pedro Chacón, Francisca Palomares, Soledad López-Enríquez

{"title":"Unraveling the role of γδ T cells in inflammatory bowel disease: Development and prevention strategies.","authors":"Ana María Múnera-Rodríguez, Camila Leiva-Castro, Pedro Chacón, Francisca Palomares, Soledad López-Enríquez","doi":"10.1016/bs.ircmb.2025.03.006","DOIUrl":"10.1016/bs.ircmb.2025.03.006","url":null,"abstract":"Inflammatory bowel diseases (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), are autoimmune disorders characterized by heterogeneous clinical manifestations and dysregulated immune responses. Central to this pathophysiology is the disruption of the intestinal mucosal and epithelial barrier, leading to dysbiosis. Among immune players, γδ (γδ) T-cells have emerged as key regulators of intestinal epithelial homeostasis. These cells, a minor subset of T lymphocytes, are distinguished by their γδ T-cell receptor (TCR) and are capable of rapidly responding to stress signals, pathogens, and tissue damage. γδ T-cells are categorized into subtypes based on their TCR repertoire, tissue distribution, and functional properties, with δ-chain expression defining subsets in humans and γ-chain in mice. In the context of IBD, γδ T-cells contribute to the pathogenesis of both UC and CD, primarily through the production of proinflammatory cytokines, such as IL-17. Furthermore, their interaction with other immune cells and the intestinal epithelium significantly impacts the local immune response and the integrity of the mucosal barrier. Notably, the crosstalk between intestinal microbiota and γδ T-cells is essential for the regulation of these cells, influencing their activation and promoting effective immune responses against bacterial infections. Given their unique immunoregulatory capabilities, γδ T-cells represent promising targets for novel therapeutic strategies aimed at not only alleviating IBD symptoms but also reducing the risk of colorectal cancer, ultimately improving long-term patient outcomes.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"397 ","pages":"47-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145329219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

γδ T cells in prostate cancer. 前列腺癌中的γδ T细胞。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-08-25 DOI: 10.1016/bs.ircmb.2025.08.001

Shiyu Wang, Xin Lu

引用次数: 0

Multi-omic features and clustering phenotypes of circulating tumor cells associated with metastasis and clinical outcomes. 循环肿瘤细胞的多组学特征和聚类表型与转移和临床结果相关。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-05-02 DOI: 10.1016/bs.ircmb.2024.03.009

Anmol Singh, Huiping Liu, Lamiaa El-Shennawy

{"title":"Multi-omic features and clustering phenotypes of circulating tumor cells associated with metastasis and clinical outcomes.","authors":"Anmol Singh, Huiping Liu, Lamiaa El-Shennawy","doi":"10.1016/bs.ircmb.2024.03.009","DOIUrl":"10.1016/bs.ircmb.2024.03.009","url":null,"abstract":"Metastasis is a lethal disease of cancer, spreading from primary tumors to the bloodstream as circulating tumor cells (CTCs), which disseminate to distant organs at low efficiency for secondary tumor regeneration, thereby contributing to unfavorable patient outcomes. The detection of dynamic CTC alterations can be indicative of cancer progression (residual cancer, aggressiveness, therapy resistance) or regression (therapy response), serving as biomarkers for diagnoses and prognoses. CTC heterogeneity is impacted by both intrinsic oncogenic changes and extrinsic microenvironmental factors (e.g. the immune system and circadian rhythm), altering the genomic/genetic, epigenomic/epigenetic, proteomic, post-translational, and metabolomic landscapes. In addition to homeostatic dynamics, regenerative stemness, and metabolic plasticity, a newly discovered feature of CTCs that influences metastatic outcomes is its intercellular clustering. While the dogma suggests that CTCs play solo as single cells in the circulation, CTCs can orchestrate with other CTCs or white blood cells to form homotypic or heterotypic multi-cellular clusters, with 20-100 times enhanced metastatic potential than single CTCs. CTC clusters promote cell survival and stemness through DNA hypomethylation and signaling pathways activated by clustering-driving proteins (CD44, CD81, ICAM1, Podocalyxin, etc). Heterotypic CTC clusters may protect CTCs from immune cell attacks if not being cleared by cytotoxic immune cells. This chapter mainly focused on CTC biology related to multi-omic features and metastatic outcomes. We speculate that CTCs could guide therapeutic targeting and be targeted specifically by anti-CTC therapeutics to reduce or eliminate cancer and cancer metastasis.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"392 ","pages":"67-100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0