International review of cell and molecular biology最新文献_第9页

Epigenetics as a determinant of radiation response in cancer. 表观遗传学是癌症辐射反应的决定因素。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2023-09-16 DOI: 10.1016/bs.ircmb.2023.07.008

Elena Arechaga-Ocampo

{"title":"Epigenetics as a determinant of radiation response in cancer.","authors":"Elena Arechaga-Ocampo","doi":"10.1016/bs.ircmb.2023.07.008","DOIUrl":"10.1016/bs.ircmb.2023.07.008","url":null,"abstract":"Radiation therapy is a cornerstone of modern cancer treatment. Treatment is based on depositing focal radiation to the tumor to inhibit cell growth, proliferation and metastasis, and to promote the death of cancer cells. In addition, radiation also affects non-tumor cells in the tumor microenvironmental (TME). Radiation resistance of the tumor cells is the most common cause of treatment failure, allowing survival of cancer cell and subsequent tumor growing. Molecular radioresistance comprises genetic and epigenetic characteristics inherent in cancer cells, or characteristics acquired after exposure to radiation. Furthermore, cancer stem cells (CSCs) and non-tumor cells into the TME as stromal and immune cells have a role in promoting and maintaining radioresistant tumor phenotypes. Different regulatory molecules and pathways distinctive of radiation resistance include DNA repair, survival signaling and cell death pathways. Epigenetic mechanisms are one of the most relevant events that occur after radiotherapy to regulate the expression and function of key genes and proteins in the differential radiation-response. This article reviews recent data on the main molecular mechanisms and signaling pathways related to the biological response to radiotherapy in cancer; highlighting the epigenetic control exerted by DNA methylation, histone marks, chromatin remodeling and m6A RNA methylation on gene expression and activation of signaling pathways related to radiation therapy response.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"383 ","pages":"145-190"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview of the Unfolded Protein Response (UPR) and Autophagy Pathways in Human Viral Oncogenesis. 人类病毒肿瘤发生过程中的折叠蛋白反应（UPR）和自噬途径概述。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-02-22 DOI: 10.1016/bs.ircmb.2024.01.004

Shovan Dutta, Anirban Ganguly, Sounak Ghosh Roy

{"title":"An Overview of the Unfolded Protein Response (UPR) and Autophagy Pathways in Human Viral Oncogenesis.","authors":"Shovan Dutta, Anirban Ganguly, Sounak Ghosh Roy","doi":"10.1016/bs.ircmb.2024.01.004","DOIUrl":"10.1016/bs.ircmb.2024.01.004","url":null,"abstract":"Autophagy and Unfolded Protein Response (UPR) can be regarded as the safe keepers of cells exposed to intense stress. Autophagy maintains cellular homeostasis, ensuring the removal of foreign particles and misfolded macromolecules from the cytoplasm and facilitating the return of the building blocks into the system. On the other hand, UPR serves as a shock response to prolonged stress, especially Endoplasmic Reticulum Stress (ERS), which also includes the accumulation of misfolded proteins in the ER. Since one of the many effects of viral infection on the host cell machinery is the hijacking of the host translational system, which leaves in its wake a plethora of misfolded proteins in the ER, it is perhaps not surprising that UPR and autophagy are common occurrences in infected cells, tissues, and patient samples. In this book chapter, we try to emphasize how UPR, and autophagy are significant in infections caused by six major oncolytic viruses-Epstein-Barr (EBV), Human Papilloma Virus (HPV), Human Immunodeficiency Virus (HIV), Human Herpesvirus-8 (HHV-8), Human T-cell Lymphotropic Virus (HTLV-1), and Hepatitis B Virus (HBV). Here, we document how whole-virus infection or overexpression of individual viral proteins in vitro and in vivo models can regulate the different branches of UPR and the various stages of macro autophagy. As is true with other viral infections, the relationship is complicated because the same virus (or the viral protein) exerts different effects on UPR and Autophagy. The nature of this response is determined by the cell types, or in some cases, the presence of diverse extracellular stimuli. The vice versa is equally valid, i.e., UPR and autophagy exhibit both anti-tumor and pro-tumor properties based on the cell type and other factors like concentrations of different metabolites. Thus, we have tried to coherently summarize the existing knowledge, the crux of which can hopefully be harnessed to design vaccines and therapies targeted at viral carcinogenesis.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"386 ","pages":"81-131"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression. 胃肠道癌症的新趋势：针对癌变和肿瘤进展的发展途径。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-01-15 DOI: 10.1016/bs.ircmb.2023.11.006

Afza Ahmad, Rohit Kumar Tiwari, Saleha Siddiqui, Muskan Chadha, Ratnakar Shukla, Vivek Srivastava

{"title":"Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression.","authors":"Afza Ahmad, Rohit Kumar Tiwari, Saleha Siddiqui, Muskan Chadha, Ratnakar Shukla, Vivek Srivastava","doi":"10.1016/bs.ircmb.2023.11.006","DOIUrl":"10.1016/bs.ircmb.2023.11.006","url":null,"abstract":"Gastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and esophageal cancers, respectively. Molecular aberrations in different signaling pathways, such as signal transduction systems or developmental pathways are the chief triggering mechanisms in different cancers Though a massive advancement in diagnostic and therapeutic interventions results in improved survival of patients with gastrointestinal cancer; the lower malignancy stages of these carcinomas are comparatively asymptomatic. Various gastrointestinal-related cancers are detected at advanced stages, leading to deplorable prognoses and increased rates of recurrence. Recent molecular studies have elucidated the imperative roles of several signaling pathways, namely Wnt, Hedgehog, and Notch signaling pathways, play in the progression, therapeutic responsiveness, and metastasis of gastrointestinal-related cancers. This book chapter gives an interesting update on recent findings on the involvement of developmental signaling pathways their mechanistic insight in gastrointestinalcancer. Subsequently, evidences supporting the exploration of gastrointestinal cancer related molecular mechanisms have also been discussed for developing novel therapeutic strategies against these debilitating carcinomas.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"385 ","pages":"41-99"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory breast cancer (IBC) advocacy-Past, present and future! 炎症性乳腺癌（IBC）宣传--过去、现在和未来！

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2023-11-21 DOI: 10.1016/bs.ircmb.2023.11.001

Jeannine Donahue, Joshlyn Earls, Valerie Fraser, Ginny Mason, Heather Pirowski, Peggy Stephens

{"title":"Inflammatory breast cancer (IBC) advocacy-Past, present and future!","authors":"Jeannine Donahue, Joshlyn Earls, Valerie Fraser, Ginny Mason, Heather Pirowski, Peggy Stephens","doi":"10.1016/bs.ircmb.2023.11.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.11.001","url":null,"abstract":"Patient advocates, referring to those individuals that have been diagnosed with the disease for which they advocate, are essential stake holders in healthcare. For those facing the stages of being diagnosed with Inflammatory Breast Cancer (IBC), the \"call to advocate\" is an immediate response to being diagnosed with a rare and aggressive disease that progresses rapidly, often in a matter of weeks or months. There is a great stigma and bias in the medical community that has inhibited the education and study of IBC. A lack of understanding of the disease, how it presents and how to treat it leaves many IBC patients facing misdiagnosis. Communication is a cornerstone of healthcare; this goes beyond the patient-provider dynamic. Education of IBC must be a grassroots initiative. There should be no barrier to care in the diagnosis, treatment, study and survivorship of inflammatory Breast Cancer. It is not just an oncologist's lesson to learn, but that of all providers in healthcare. In this chapter you will hear how 4 women who were diagnosed with IBC faced the difficult tasks of navigating through the healthcare system on their own and came out on the other side using their experience to help others. In conclusion, in defining the evolving roles of Patient Advocacy in IBC over the past 25 years, we examine what has been done, along with its challenges, and what work still remains from the perspectives of different patient advocates.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"384 ","pages":"153-164"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-generation deconvolution of transcriptomic data to investigate the tumor microenvironment. 下一代转录组数据解卷积研究肿瘤微环境。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2023-06-21 DOI: 10.1016/bs.ircmb.2023.05.002

Lorenzo Merotto, Maria Zopoglou, Constantin Zackl, Francesca Finotello

引用次数: 0

Recent advancements in tumour microenvironment landscaping for target selection and response prediction in immune checkpoint therapies achieved through spatial protein multiplexing analysis. 通过空间蛋白复用分析实现免疫检查点疗法的靶点选择和反应预测的肿瘤微环境景观设计的最新进展。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2023-06-14 DOI: 10.1016/bs.ircmb.2023.05.009

Madhavi Dipak Andhari, Asier Antoranz, Frederik De Smet, Francesca Maria Bosisio

{"title":"Recent advancements in tumour microenvironment landscaping for target selection and response prediction in immune checkpoint therapies achieved through spatial protein multiplexing analysis.","authors":"Madhavi Dipak Andhari, Asier Antoranz, Frederik De Smet, Francesca Maria Bosisio","doi":"10.1016/bs.ircmb.2023.05.009","DOIUrl":"10.1016/bs.ircmb.2023.05.009","url":null,"abstract":"Immune checkpoint therapies have significantly advanced cancer treatment. Nevertheless, the high costs and potential adverse effects associated with these therapies highlight the need for better predictive biomarkers to identify patients who are most likely to benefit from treatment. Unfortunately, the existing biomarkers are insufficient to identify such patients. New high-dimensional spatial technologies have emerged as a valuable tool for discovering novel biomarkers by analysing multiple protein markers at a single-cell resolution in tissue samples. These technologies provide a more comprehensive map of tissue composition, cell functionality, and interactions between different cell types in the tumour microenvironment. In this review, we provide an overview of how spatial protein-based multiplexing technologies have fuelled biomarker discovery and advanced the field of immunotherapy. In particular, we will focus on how these technologies contributed to (i) characterise the tumour microenvironment, (ii) understand the role of tumour heterogeneity, (iii) study the interplay of the immune microenvironment and tumour progression, (iv) discover biomarkers for immune checkpoint therapies (v) suggest novel therapeutic strategies.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"382 ","pages":"207-237"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of hedgehog signaling in advanced cancer types. 刺猬信号在晚期癌症类型中的治疗潜力。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.1016/bs.ircmb.2024.01.003

Richa Singh, Anindita Ray

{"title":"Therapeutic potential of hedgehog signaling in advanced cancer types.","authors":"Richa Singh, Anindita Ray","doi":"10.1016/bs.ircmb.2024.01.003","DOIUrl":"10.1016/bs.ircmb.2024.01.003","url":null,"abstract":"In this chapter, we have made an attempt to elucidate the relevance of hedgehog signaling pathway in tumorigenesis. Here, we have described different types of hedgehog signaling (canonical and non-canonical) with emphasis on the different mechanisms (mutation-driven, autocrine, paracrine and reverse paracrine) it adopts during tumorigenesis. We have discussed the role of hedgehog signaling in regulating cell proliferation, invasion and epithelial-to-mesenchymal transition in both local and advanced cancer types, as reported in different studies based on preclinical and clinical models. We have specifically addressed the role of hedgehog signaling in aggressive neuroendocrine tumors as well. We have also elaborated on the studies showing therapeutic relevance of the inhibitors of hedgehog signaling in cancer. Evidence of the crosstalk of hedgehog signaling components with other signaling pathways and treatment resistance due to tumor heterogeneity have also been briefly discussed. Together, we have tried to put forward a compilation of the studies on therapeutic potential of hedgehog signaling in various cancers, specifically aggressive tumor types with a perspective into what is lacking and demands further investigation.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"386 ","pages":"49-80"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of interferon dependent and independent signaling pathways: Implications in cancer. 干扰素依赖和独立信号通路的作用：对癌症的影响

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-08-02 DOI: 10.1016/bs.ircmb.2024.06.004

Sheila Spada, Anirban Ganguly

引用次数: 0

Epigenetic inhibitors for cancer treatment. 用于治疗癌症的表观遗传抑制剂。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2023-07-18 DOI: 10.1016/bs.ircmb.2023.06.003

Hongchao Yuan, Yuanjun Lu, Yibin Feng, Ning Wang

引用次数: 0

Multifaceted perspectives of detecting and targeting solid tumors. 检测和靶向实体瘤的多角度视角。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-06-01 DOI: 10.1016/bs.ircmb.2024.03.010

Abhishek Bhattacharya, Anjan Kr Dasgupta

{"title":"Multifaceted perspectives of detecting and targeting solid tumors.","authors":"Abhishek Bhattacharya, Anjan Kr Dasgupta","doi":"10.1016/bs.ircmb.2024.03.010","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.03.010","url":null,"abstract":"Solid tumors are the most prevalent form of cancer. Considerable technological and medical advancements had been achieved for the diagnosis of the disease. However, detection of the disease in an early stage is of utmost importance, still far from reality. On the contrary, the treatment and therapeutic area to combat solid tumors are still in its infancy. Conventional treatments like chemotherapy and radiation therapy pose challenges due to their indiscriminate impact on healthy and cancerous cells. Contextually, efficient drug targeting is a pivotal approach in solid tumor treatment. This involves the precise delivery of drugs to cancer cells while minimizing harm to healthy cells. Targeted drugs exhibit superior efficacy in eradicating cancer cells while impeding tumor growth and mitigate side effects by optimizing absorption which further diminishes the risk of resistance. Furthermore, tailoring targeted therapies to a patient's tumor-specific molecular profile augments treatment efficacy and reduces the likelihood of relapse. This chapter discuss about the distinctive characteristics of solid tumors, the possibility of early detection of the disease and potential therapeutic angle beyond the conventional approaches. Additionally, the chapter delves into a hitherto unknown attribute of magnetic field effect to target cancer cells which exploit the relatively less susceptibility of normal cells compared to cancer cells to magnetic fields, suggesting a future potential of magnetic nanoparticles for selective cancer cell destruction. Lastly, bioinformatics tools and other unconventional methodologies such as AI-assisted codon bias analysis have a crucial role in comprehending tumor biology, aiding in the identification of futuristic targeted therapies.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"389 ","pages":"1-66"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0