International review of cell and molecular biology最新文献_第8页

Novel insights into DNA methylation-based epigenetic regulation of breast tumor angiogenesis. 基于DNA甲基化的乳腺肿瘤血管生成表观遗传调控的新见解。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.04.002

Sharath Mohan Bhat, Palla Ranga Prasad, Manjunath B Joshi

{"title":"Novel insights into DNA methylation-based epigenetic regulation of breast tumor angiogenesis.","authors":"Sharath Mohan Bhat, Palla Ranga Prasad, Manjunath B Joshi","doi":"10.1016/bs.ircmb.2023.04.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.04.002","url":null,"abstract":"Breast tumors are highly vascularized and dependent on angiogenesis for growth, progression and metastasis. Like other solid tumors, vasculature in breast tumors also display leaky and tortuous phenotype and hence inhibit immune cell infiltration, show reduced efficacy to anticancer drugs and radiotherapy. Epigenetic reprogramming including significant alterations in DNA methylation in tumor and stromal cells generate an imbalance in expression of pro- and anti-angiogenic factors and subsequently lead to disordered angiogenesis. Hence, understanding DNA methylation-based regulation of angiogenesis in breast tumors may open new avenues for designing therapeutic targets. Our present review manuscript summarized contemporary knowledge of influence of DNA methylation in regulating angiogenesis. Further, we identified novel set of pro-angiogenic genes enriched in endothelial cells which are coregulated with DNMT isoforms in breast tumors and harboring CpG islands. Our analysis revealed promoters of pro-angiogenic genes were hypomethylated and anti-angiogenic genes were hypermethylated in tumors and further reflected on their expression patterns. Interestingly, promoter DNA methylation intensities of novel set of pro-angiogenic genes significantly correlated to patient survival outcome.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10159657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of radiation therapy on healthy tissues. 放射治疗对健康组织的影响。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2022.11.006

Cyrus Chargari, Elie Rassy, Carole Helissey, Samir Achkar, Sabine Francois, Eric Deutsch

{"title":"Impact of radiation therapy on healthy tissues.","authors":"Cyrus Chargari, Elie Rassy, Carole Helissey, Samir Achkar, Sabine Francois, Eric Deutsch","doi":"10.1016/bs.ircmb.2022.11.006","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2022.11.006","url":null,"abstract":"Radiation therapy has a fundamental role in the management of cancers. However, despite a constant improvement in radiotherapy techniques, the issue of radiation-induced side effects remains clinically relevant. Mechanisms of acute toxicity and late fibrosis are therefore important topics for translational research to improve the quality of life of patients treated with ionizing radiations. Tissue changes observed after radiotherapy are consequences of complex pathophysiology, involving macrophage activation, cytokine cascade, fibrotic changes, vascularization disorders, hypoxia, tissue destruction and subsequent chronic wound healing. Moreover, numerous data show the impact of these changes in the irradiated stroma on the oncogenic process, with interplays between tumor radiation response and pathways involved in the fibrotic process. The mechanisms of radiation-induced normal tissue inflammation are reviewed, with a focus on the impact of the inflammatory process on the onset of treatment-related toxicities and the oncogenic process. Possible targets for pharmacomodulation are also discussed.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9452264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis. 解决非常规循环肿瘤细胞的不确定性：上皮-间充质转化、细胞融合和胞嘧啶。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-08-08 DOI: 10.1016/bs.ircmb.2023.07.004

Giulia Gallerani, Tania Rossi, Manuela Ferracin, Massimiliano Bonafè

引用次数: 0

The various functions and phenotypes of macrophages are also reflected in their responses to irradiation: A current overview. 巨噬细胞的各种功能和表型也反映在它们对辐照的反应中:当前概述。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.01.002

Lisa Deloch, Michael Rückert, Thomas Weissmann, Sebastian Lettmaier, Eva Titova, Teresa Wolff, Felix Weinrich, Rainer Fietkau, Udo S Gaipl

{"title":"The various functions and phenotypes of macrophages are also reflected in their responses to irradiation: A current overview.","authors":"Lisa Deloch, Michael Rückert, Thomas Weissmann, Sebastian Lettmaier, Eva Titova, Teresa Wolff, Felix Weinrich, Rainer Fietkau, Udo S Gaipl","doi":"10.1016/bs.ircmb.2023.01.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.01.002","url":null,"abstract":"Macrophages are a vital part of the innate immune system that are involved in healthy biological processes but also in disease modulation and response to therapy. Ionizing radiation is commonly used in the treatment of cancer and, in a lower dose range, as additive therapy for inflammatory diseases. In general, lower doses of ionizing radiation are known to induce rather anti-inflammatory responses, while higher doses are utilized in cancer treatment where they result, next to tumor control, in rather inflammatory responses. Most experiments that have been carried out in ex vivo on macrophages find this to be true, however in vivo, tumor-associated macrophages, for example, show a contradictory response to the respective dose-range. While some knowledge in radiation-induced modulations of macrophages has been collected, many of the underlying mechanisms remain unclear. Due to their pivotal role in the human body, however, they are a great target in therapy and could potentially aid in better treatment outcome. We therefore summarized the current knowledge of macrophage mediated radiation responses.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9452265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual impact of radiation therapy on tumor-targeting immune responses. 放射治疗对肿瘤靶向免疫反应的双重影响。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/S1937-6448(23)00114-4

Céline Mirjolet, Jérémy Baude, Lorenzo Galluzzi

引用次数: 0

Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sites. 癌症中的超级增强子景观重新布线:远端位点的表观遗传控制。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.03.013

Eros Di Giorgio, Roberta Benetti, Emanuela Kerschbamer, Luigi Xodo, Claudio Brancolini

引用次数: 0

Models to study CTCs and CTC culture methods. 研究CTC和CTC培养方法的模型。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-08-03 DOI: 10.1016/bs.ircmb.2023.07.007

Cristóbal Fernández-Santiago, Rafael López-López, Roberto Piñeiro

{"title":"Models to study CTCs and CTC culture methods.","authors":"Cristóbal Fernández-Santiago, Rafael López-López, Roberto Piñeiro","doi":"10.1016/bs.ircmb.2023.07.007","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.07.007","url":null,"abstract":"The vast majority of cancer-related deaths are due to the presence of disseminated disease. Understanding the metastatic process is key to achieving a reduction in cancer mortality. Particularly, there is a need to understand the molecular mechanisms that drive cancer metastasis, which will allow the identification of curative treatments for metastatic cancers. Liquid biopsies have arisen as a minimally invasive approach to gain insights into the biology of metastasis. Circulating tumour cells (CTCs), shed to the circulation from the primary tumour or metastatic lesions, are a key component of liquid biopsy. As metastatic precursors, CTCs hold the potential to unravel the mechanisms involved in metastasis formation as well as new therapeutic strategies for treating metastatic disease. However, the complex biology of CTCs together with their low frequency in circulation are factors hampering an in-depth mechanistic investigation of the metastatic process. To overcome these problems, CTC-derived models, including CTC-derived xenograft (CDX) and CTC-derived ex vivo cultures, in combination with more traditional in vivo models of metastasis, have emerged as powerful tools to investigate the biological features of CTCs facilitating cancer metastasis and uncover new therapeutic opportunities. In this chapter, we provide an up to date view of the diverse models used in different cancers to study the biology of CTCs, and of the methods developed for CTC culture and expansion, in vivo and ex vivo. We also report some of the main challenges and limitations that these models are facing.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41101107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncolytic viruses in hematological malignancies: hijacking disease biology and fostering new promises for immune and cell-based therapies. 恶性血液病中的溶瘤病毒:劫持疾病生物学并促进免疫和细胞治疗的新前景。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.05.001

Mário Sousa-Pimenta, Ângelo Martins, Vera Machado

{"title":"Oncolytic viruses in hematological malignancies: hijacking disease biology and fostering new promises for immune and cell-based therapies.","authors":"Mário Sousa-Pimenta, Ângelo Martins, Vera Machado","doi":"10.1016/bs.ircmb.2023.05.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.05.001","url":null,"abstract":"The increased tropism for malignant cells of some viruses has been highlighted in recent studies, prompting their use as a strategy to modify the transcriptional profile of those cells, while sparing the healthy ones. Likewise, they have been recognized as players modulating microenvironmental immunity, namely through an increase in antigen-presenting, natural-killer, and T CD8+ cytotoxic cells by a cross-priming mechanism elicited by tumor-associated antigens. The immunomodulatory role of the oncolytic virus seems relevant in hematological malignancies, which may relapse as a result of a proliferative burst elicited by an external stimulus in progenitor or neoplastic stem cells. By reprogramming the host cells and the surrounding environment, the potential of virotherapy ranges from the promise to eradicate the minimal measurable disease (in acute leukemia, for example), to the ex vivo purging of malignant progenitor cells in the setting of autologous bone marrow transplantation. In this review, we analyze the recent advances in virotherapy in hematological malignancies, either when administered alone or together with chemotherapeutic agents or other immunomodulators.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9948624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation of epithelial-mesenchymal transition during cancer development. 肿瘤发生过程中上皮-间质转化的表观遗传调控。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.05.007

Sunisa Yoodee, Visith Thongboonkerd

引用次数: 0

Epigenetic inhibitors and their role in cancer therapy. 表观遗传抑制剂及其在癌症治疗中的作用。

3区生物学

International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.04.005

Nouha Abdelaziz, Lubna Therachiyil, Hana Q Sadida, Ateeque Mohamed Ali, Omar S Khan, Mayank Singh, Abdul Q Khan, Ammira S Al-Shabeeb Akil, Ajaz A Bhat, Shahab Uddin

引用次数: 0