Hamda Khan, Zeeshan Rafi, Mohd Yasir Khan, Farah Maarfi, Shahnawaz Rehman, Kirtanjot Kaur, Mohammad Kaleem Ahmad, Uzma Shahab, Naved Ahmad, Saheem Ahmad
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引用次数: 0
摘要
高级糖化终产物(AGEs)在人体内的半衰期较长,正在成为有效的诊断指标。以 AGE 交联断裂物为重点的早期干预研究在心衰患者中取得了令人鼓舞的结果,为疾病进展监测和疗效评估铺平了道路。AGE 是糖与蛋白质、脂类和核酸相互作用的非酶反应的副产品。这些化合物能够改变许多生物过程,包括破坏分子构象、促进交联、改变酶活性、降低清除率和损害受体识别等。AGEs 通过刺激细胞内信号通路造成的损害与各器官系统慢性疾病的发病有关。本综述总结了 AGEs 的特点及其在不同生理和病理状态下的表达所带来的挑战。此外,它还强调了 AGEs 的临床意义以及旨在减少 AGE 积累的最新研究突破。
Epigenetic contributions to cancer: Exploring the role of glycation reactions.
Advanced Glycation End-products (AGEs), with their prolonged half-life in the human body, are emerging as potent diagnostic indicators. Early intervention studies, focusing on AGE cross-link breakers, have shown encouraging results in heart failure patients, paving the way for disease progression monitoring and therapy effectiveness evaluation. AGEs are the byproducts of a non-enzymatic reaction where sugars interact with proteins, lipids, and nucleic acids. These compounds possess the power to alter numerous biological processes, ranging from disrupting molecular conformation and promoting cross-linking to modifying enzyme activity, reducing clearance, and impairing receptor recognition. The damage inflicted by AGEs through the stimulation of intracellular signaling pathways is associated with the onset of chronic diseases across various organ systems. This review consolidates the characteristics of AGEs and the challenges posed by their expression in diverse physiological and pathological states. Furthermore, it highlights the clinical relevance of AGEs and the latest research breakthroughs aimed at reducing AGE accumulation.
期刊介绍:
International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.