癌症早期转移性循环肿瘤细胞临床研究的最新进展。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Laura S Munoz-Arcos, Eleonora Nicolò, Mara S Serafini, Lorenzo Gerratana, Carolina Reduzzi, Massimo Cristofanilli
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引用次数: 0

摘要

循环肿瘤细胞(CTCs)已成为癌症中一种很有前途的生物标志物,为疾病进展和治疗反应提供了见解。虽然CTC已证明与早期癌症的预后相关,但需要更多的验证来确定最佳临界点。在转移性癌症中,使用食品和药物管理局批准的CellSearch®系统检测CTC是一个强大的独立预后因素。然而,间充质CTC和Parsortix®PC1系统显示出作为替代检测方法的前景。本章对癌症CTC的临床研究进行了全面回顾,强调了其在疾病不同阶段的预后和预测价值,并对CTC研究的潜在未来方向提供了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer.

Circulating tumor cells (CTCs) have emerged as a promising biomarker in breast cancer, offering insights into disease progression and treatment response. While CTCs have demonstrated prognostic relevance in early breast cancer, more validation is required to establish optimal cut-off points. In metastatic breast cancer, the detection of CTCs using the Food and Drug Administration-approved CellSearch® system is a strong independent prognostic factor. However, mesenchymal CTCs and the Parsortix® PC1 system show promise as alternative detection methods. This chapter offers a comprehensive review of clinical studies on CTCs in breast cancer, emphasizing their prognostic and predictive value in different stages of the disease and provides insights into potential future directions in CTC research.

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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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