Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis.

3区生物学 Q1 Biochemistry, Genetics and Molecular Biology

International review of cell and molecular biology Pub Date : 2023-01-01 Epub Date: 2023-08-08 DOI:10.1016/bs.ircmb.2023.07.004

Giulia Gallerani, Tania Rossi, Manuela Ferracin, Massimiliano Bonafè

{"title":"Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis.","authors":"Giulia Gallerani, Tania Rossi, Manuela Ferracin, Massimiliano Bonafè","doi":"10.1016/bs.ircmb.2023.07.004","DOIUrl":null,"url":null,"abstract":"<p><p>Circulating tumor cells (CTCs) were first described 150 years ago. The so-called \"classical\" CTC populations (EpCAM+/CK+/CD45-) have been fully characterized and proposed as the most representative CTC subset, with clinical relevance. Nonetheless, other \"atypical\" or \"unconventional\" CTCs have also been identified, and their critical role in metastasis formation was demonstrated. In this chapter we illustrate the studies that led to the discovery of unconventional CTCs, defined as CTCs that display both epithelial and mesenchymal markers, or both cancer and immune markers, also in the form of hybrid cancer-immune cells. We also present biological explanations for the origin of these unconventional CTCs: epithelial to mesenchymal transition, cell-cell fusion and trogocytosis. We believe that a deeper knowledge on the biology of CTCs is needed to fully elucidate their role in cancer progression and their use as cancer biomarkers.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International review of cell and molecular biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/bs.ircmb.2023.07.004","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/8 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}

引用次数: 0

Abstract

Circulating tumor cells (CTCs) were first described 150 years ago. The so-called "classical" CTC populations (EpCAM+/CK+/CD45-) have been fully characterized and proposed as the most representative CTC subset, with clinical relevance. Nonetheless, other "atypical" or "unconventional" CTCs have also been identified, and their critical role in metastasis formation was demonstrated. In this chapter we illustrate the studies that led to the discovery of unconventional CTCs, defined as CTCs that display both epithelial and mesenchymal markers, or both cancer and immune markers, also in the form of hybrid cancer-immune cells. We also present biological explanations for the origin of these unconventional CTCs: epithelial to mesenchymal transition, cell-cell fusion and trogocytosis. We believe that a deeper knowledge on the biology of CTCs is needed to fully elucidate their role in cancer progression and their use as cancer biomarkers.

查看原文本刊更多论文

解决非常规循环肿瘤细胞的不确定性：上皮-间充质转化、细胞融合和胞嘧啶。

循环肿瘤细胞（CTC）在150年前首次被描述。所谓的“经典”CTC群体（EpCAM+/CK+/CD45-）已被充分表征，并被认为是最具代表性的CTC亚群，具有临床相关性。尽管如此，也发现了其他“非典型”或“非常规”CTC，并证明了它们在转移形成中的关键作用。在本章中，我们说明了导致发现非常规CTC的研究，即同时显示上皮和间充质标志物，或同时显示癌症和免疫标志物的CTC，也以混合癌-免疫细胞的形式。我们还对这些非常规CTC的起源提出了生物学解释：上皮-间充质转化、细胞-细胞融合和胞嘧啶作用。我们认为，需要对CTC的生物学有更深入的了解，以充分阐明它们在癌症进展中的作用及其作为癌症生物标志物的用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY

CiteScore

7.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.