Epigenetic regulation of epithelial-mesenchymal transition during cancer development.

3区生物学 Q1 Biochemistry, Genetics and Molecular Biology

International review of cell and molecular biology Pub Date : 2023-01-01 DOI:10.1016/bs.ircmb.2023.05.007

Sunisa Yoodee, Visith Thongboonkerd

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Abstract

Epithelial-mesenchymal transition (EMT) plays essential roles in promoting malignant transformation of epithelial cells, leading to cancer progression and metastasis. During EMT-induced cancer development, a wide variety of genes are dramatically modified, especially down-regulation of epithelial-related genes and up-regulation of mesenchymal-related genes. Expression of other EMT-related genes is also modified during the carcinogenic process. Especially, epigenetic modifications are observed in the EMT-related genes, indicating their involvement in cancer development. Mechanically, epigenetic modifications of histone, DNA, mRNA and non-coding RNA stably change the EMT-related gene expression at transcription and translation levels. Herein, we summarize current knowledge on epigenetic regulatory mechanisms observed in EMT process relate to cancer development in humans. The better understanding of epigenetic regulation of EMT during cancer development may lead to improvement of drug design and preventive strategies in cancer therapy.

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肿瘤发生过程中上皮-间质转化的表观遗传调控。

上皮-间质转化(epithelial -mesenchymal transition, EMT)在促进上皮细胞的恶性转化，导致癌症的进展和转移中起着至关重要的作用。在emt诱导的癌症发展过程中，多种基因被显著修饰，尤其是上皮相关基因的下调和间质相关基因的上调。其他emt相关基因的表达在致癌过程中也会发生改变。特别是在emt相关基因中观察到表观遗传修饰，表明它们参与了癌症的发展。机械地，组蛋白、DNA、mRNA和非编码RNA的表观遗传修饰在转录和翻译水平上稳定地改变了emt相关基因的表达。在此，我们总结了目前关于EMT过程中观察到的与人类癌症发展相关的表观遗传调控机制的知识。更好地了解EMT在癌症发展过程中的表观遗传调控可能有助于改进癌症治疗中的药物设计和预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY

CiteScore

7.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.