恶性血液病中的溶瘤病毒:劫持疾病生物学并促进免疫和细胞治疗的新前景。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Mário Sousa-Pimenta, Ângelo Martins, Vera Machado
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引用次数: 0

摘要

在最近的研究中,一些病毒对恶性细胞的趋向性增加,促使它们作为一种策略来修改这些细胞的转录谱,同时保留健康细胞。同样,它们也被认为是调节微环境免疫的参与者,即通过肿瘤相关抗原引发的交叉启动机制,通过增加抗原呈递、自然杀伤和T CD8+细胞毒性细胞。溶瘤病毒的免疫调节作用似乎与血液系统恶性肿瘤有关,这些恶性肿瘤可能由于外部刺激引起祖细胞或肿瘤干细胞的增殖爆发而复发。通过对宿主细胞和周围环境进行重新编程,病毒疗法的潜力范围从有望根除最小可测量的疾病(例如急性白血病)到在自体骨髓移植环境中清除恶性祖细胞。在这篇综述中,我们分析了血液系统恶性肿瘤病毒治疗的最新进展,无论是单独使用还是与化疗药物或其他免疫调节剂联合使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oncolytic viruses in hematological malignancies: hijacking disease biology and fostering new promises for immune and cell-based therapies.

The increased tropism for malignant cells of some viruses has been highlighted in recent studies, prompting their use as a strategy to modify the transcriptional profile of those cells, while sparing the healthy ones. Likewise, they have been recognized as players modulating microenvironmental immunity, namely through an increase in antigen-presenting, natural-killer, and T CD8+ cytotoxic cells by a cross-priming mechanism elicited by tumor-associated antigens. The immunomodulatory role of the oncolytic virus seems relevant in hematological malignancies, which may relapse as a result of a proliferative burst elicited by an external stimulus in progenitor or neoplastic stem cells. By reprogramming the host cells and the surrounding environment, the potential of virotherapy ranges from the promise to eradicate the minimal measurable disease (in acute leukemia, for example), to the ex vivo purging of malignant progenitor cells in the setting of autologous bone marrow transplantation. In this review, we analyze the recent advances in virotherapy in hematological malignancies, either when administered alone or together with chemotherapeutic agents or other immunomodulators.

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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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