International review of cell and molecular biology最新文献_第4页

Microbiome-mediated immune modulation in tumor microenvironment. 肿瘤微环境中微生物介导的免疫调节。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-02-17 DOI: 10.1016/bs.ircmb.2024.12.012

John Richards, Eleanor L Davis, L Shakila, Janani Narayanan, Sadhna Aggarwal, Anshuman Mishra, Kranthi Kumar Madamchetty Venkata, Brandon K Walther, Abishai Dominic

{"title":"Microbiome-mediated immune modulation in tumor microenvironment.","authors":"John Richards, Eleanor L Davis, L Shakila, Janani Narayanan, Sadhna Aggarwal, Anshuman Mishra, Kranthi Kumar Madamchetty Venkata, Brandon K Walther, Abishai Dominic","doi":"10.1016/bs.ircmb.2024.12.012","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.12.012","url":null,"abstract":"This chapter explores the complex interplay between the tumor microenvironment (TME), the microbiome, and the immune system. It focuses on how microbes and their metabolites influence tumor development, progression, and the subsequent immune responses. The TME is a highly complex environment made up of cancer cells, immune cells, and the extracellular matrix, where immune cells can either inhibit or promote tumor growth depending on the context. The chapter highlights several key mechanisms of interaction, including microbial metabolites, the presentation of microbial antigens by tumor or immune cells, and the role of immune checkpoints, such as PD-L1, in modulating immune responses. Certain bacteria, viruses, and fungi can trigger immune responses that lead to the destruction of cancer cells, often through processes such as immunogenic cell death (ICD). Conversely, dysbiosis, or an imbalance in microbial communities, can create a pro-tumorigenic environment, aiding in tumor progression through chronic inflammation, immune suppression, and metabolic alterations. The chapter categorizes microbial interactions with cancer into three areas: microbes directly causing cancer (e.g., Epstein-Barr virus and HPV), cancers that induce infections (e.g., obstructing the respiratory or digestive systems), and tumors located in organs with natural microbiomes, such as the gastrointestinal tract. In addition to these mechanisms, the chapter also illuminates how microbial antigens can serve as potential identifiers and tools for cancer diagnosis and treatment, offering new avenues for personalized medicine. The insights gained from this exploration are important for advancing microbial-based therapies and improving the effectiveness of immunotherapies in cancer treatment.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"394 ","pages":"107-145"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation of cancer. 癌症的表观遗传调控。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 DOI: 10.1016/S1937-6448(25)00015-2

Lorenzo Galluzzi, Sheila Spada

引用次数: 0

The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer. 表观遗传调节生物活性植物化学物质作为辅助治疗癌症的翻译潜力。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-10-02 DOI: 10.1016/bs.ircmb.2024.09.003

Priya Mondal, Gowthami Jayaprakash, Syed Musthapa Meeran

{"title":"The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer.","authors":"Priya Mondal, Gowthami Jayaprakash, Syed Musthapa Meeran","doi":"10.1016/bs.ircmb.2024.09.003","DOIUrl":"10.1016/bs.ircmb.2024.09.003","url":null,"abstract":"In preclinical studies, bioactive phytochemicals have shown enormous potential therapeutic efficacy against various human malignancies. These natural compounds have been shown to possess an inherent potential to alter the molecular signaling pathways and epigenetic modulatory activity involved in multiple physiological functions. Recently, epigenetic therapy has emerged as an important therapeutic modality due to the reversible nature of epigenetic alterations. To date, epigenetic modulatory compounds, for example, DNA methyltransferase inhibitors 5-azacytidine and 5'-deoxyazacytidine, as well as histone deacetylase inhibitors Vorinostat, Romidepsin, and Belinostat (PXD101), have been clinically approved by the FDA for the treatment of patients of leukemia and myelodysplastic syndrome. However, these synthetic epigenetic inhibitors are not as effective against many of the solid tumors. Therefore, the epigenetic modulatory phytochemicals provide new hope for improving the treatment modality as neoadjuvant and adjuvant therapy. It has been established that targeting more than one protein in the transformed cells simultaneously, that is, the multi-targeted therapeutic approach, might invoke a better therapeutic response. Therefore, here, we are compiling diverse evidences of the translational potential of novel combinatorial approaches utilizing the epigenetic modulatory phytochemicals with available therapeutics in the course of cancer treatment.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"390 ","pages":"140-185"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omic features and clustering phenotypes of circulating tumor cells associated with metastasis and clinical outcomes. 循环肿瘤细胞的多组学特征和聚类表型与转移和临床结果相关。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-05-02 DOI: 10.1016/bs.ircmb.2024.03.009

Anmol Singh, Huiping Liu, Lamiaa El-Shennawy

{"title":"Multi-omic features and clustering phenotypes of circulating tumor cells associated with metastasis and clinical outcomes.","authors":"Anmol Singh, Huiping Liu, Lamiaa El-Shennawy","doi":"10.1016/bs.ircmb.2024.03.009","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.03.009","url":null,"abstract":"Metastasis is a lethal disease of cancer, spreading from primary tumors to the bloodstream as circulating tumor cells (CTCs), which disseminate to distant organs at low efficiency for secondary tumor regeneration, thereby contributing to unfavorable patient outcomes. The detection of dynamic CTC alterations can be indicative of cancer progression (residual cancer, aggressiveness, therapy resistance) or regression (therapy response), serving as biomarkers for diagnoses and prognoses. CTC heterogeneity is impacted by both intrinsic oncogenic changes and extrinsic microenvironmental factors (e.g. the immune system and circadian rhythm), altering the genomic/genetic, epigenomic/epigenetic, proteomic, post-translational, and metabolomic landscapes. In addition to homeostatic dynamics, regenerative stemness, and metabolic plasticity, a newly discovered feature of CTCs that influences metastatic outcomes is its intercellular clustering. While the dogma suggests that CTCs play solo as single cells in the circulation, CTCs can orchestrate with other CTCs or white blood cells to form homotypic or heterotypic multi-cellular clusters, with 20-100 times enhanced metastatic potential than single CTCs. CTC clusters promote cell survival and stemness through DNA hypomethylation and signaling pathways activated by clustering-driving proteins (CD44, CD81, ICAM1, Podocalyxin, etc). Heterotypic CTC clusters may protect CTCs from immune cell attacks if not being cleared by cytotoxic immune cells. This chapter mainly focused on CTC biology related to multi-omic features and metastatic outcomes. We speculate that CTCs could guide therapeutic targeting and be targeted specifically by anti-CTC therapeutics to reduce or eliminate cancer and cancer metastasis.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"392 ","pages":"67-100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian rhythms and cardiac physiology: An essential interplay. 昼夜节律和心脏生理：一个必要的相互作用。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-07-17 DOI: 10.1016/bs.ircmb.2024.07.001

Rosanna Caputo, Alessandra Idini, Carolina Magdalen Greco

{"title":"Circadian rhythms and cardiac physiology: An essential interplay.","authors":"Rosanna Caputo, Alessandra Idini, Carolina Magdalen Greco","doi":"10.1016/bs.ircmb.2024.07.001","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.07.001","url":null,"abstract":"Virtually every cell in the human body contains a molecular circadian clock that orchestrates the rhythmic oscillations of a multitude of tissue-specific functions. This is evident in the heart, where circadian rhythms are seen in various cardiac functions. Genetic disruption of clock genes has underscored their significance in regulating multiple aspects of cardiac physiology. In this review, we report the principal findings regarding the impact of clock gene manipulation (whole body or cardiomyocyte specific) on cardiac function. Furthermore, we present the current knowledge on the circadian clock in the different cell populations in the heart-cardiomyocytes, endothelial cells, fibroblasts, and immune cells. While increasing studies have shown mechanistic links between core clock components and cardiomyocytes-specific genes, the information of clock function within other cardiac cells in the heart is extremely limited. This review underlines the need to gain more information on the temporal segregation of clock processes in cardiac-especially in non-cardiomyocytes-cells, as clock-controlled mechanism may be target of chronotherapy to optimize current treatments for cardiovascular diseases.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"393 ","pages":"15-44"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune diseases and microbiome targeted therapies. 自身免疫性疾病和微生物组靶向治疗。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-02-11 DOI: 10.1016/bs.ircmb.2024.12.007

Preeti Jain, Nitika Joshi, Vishal Sahu, Abishai Dominic, Sadhna Aggarwal

引用次数: 0

Circulation tumor cell isolation and enrichment technologies. 循环肿瘤细胞分离富集技术。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-02-24 DOI: 10.1016/bs.ircmb.2025.01.009

Youbin Zhang, David Scholten, Wenan Qiang, Leonidas C Platanias, William J Gradishar, Shana O Kelley, Huiping Liu

{"title":"Circulation tumor cell isolation and enrichment technologies.","authors":"Youbin Zhang, David Scholten, Wenan Qiang, Leonidas C Platanias, William J Gradishar, Shana O Kelley, Huiping Liu","doi":"10.1016/bs.ircmb.2025.01.009","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2025.01.009","url":null,"abstract":"During cancer metastasis, tumor cells migrate from the primary tumor site and spread to distant tissue or organs through the circulatory system of the body. While it is challenging to track metastatic tumor cells, circulating tumor cells (CTCs) via liquid biopsy provide a unique and important opportunity for longitudinal monitoring of residual cancer diseases and progression, showing great potential to facilitate precision medicine in cancer patients. The enumeration and characterization of CTCs represent prognostic and predictive biomarkers, which can be used to monitor the response to and efficacy of various therapies. Along with molecular and cellular features of CTCs, this data can inform the detection of early micro-metastases and assess progression of advanced disease in a more sensitive manner than traditional imaging modalities, serving as a complementary approach with added value. Nevertheless, comprehensive multiomic analyses of CTCs at inter-cellular (cluster), single-cell, and subcellular levels to elucidate relevant CTC cancer biology, tumor immune ecosystem biology, and clinical outcomes have yet to be achieved, demanding multidisciplinary collaboration to advance the field. Complementary to the published chapter on multiomic analyses and functional properties of CTCs, this chapter summarizes key methods and integrated strategies in CTC isolation, highlighting an accelerated evolution in high-throughput analysis of CTCs.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"392 ","pages":"119-149"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nectin-4: A promising prognostic marker and therapeutic target in cancer. Nectin-4：一种有前景的癌症预后标志物和治疗靶点。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-12 DOI: 10.1016/bs.ircmb.2024.08.004

Shilpa Kuttikrishnan, Kirti S Prabhu, Ummu Habeeba, Zahwa Mariyam, Queenie Fernandes, Mohsin Maqbool, Omar M Khan, Ajaz A Bhat, Shahab Uddin

{"title":"Nectin-4: A promising prognostic marker and therapeutic target in cancer.","authors":"Shilpa Kuttikrishnan, Kirti S Prabhu, Ummu Habeeba, Zahwa Mariyam, Queenie Fernandes, Mohsin Maqbool, Omar M Khan, Ajaz A Bhat, Shahab Uddin","doi":"10.1016/bs.ircmb.2024.08.004","DOIUrl":"10.1016/bs.ircmb.2024.08.004","url":null,"abstract":"Nectin cell adhesion protein 4 (Nectin-4), a calcium-independent immunoglobulin-like protein, has garnered significant attention in oncology due to its pronounced overexpression in malignant tumors and absence in healthy adult tissues. Elevated levels of Nectin-4 have been implicated in the pathogenesis of various cancers, including lung, breast, and urothelial carcinomas. Notably, Nectin-4 has emerged as a promising serological marker for these malignancies, facilitating early diagnosis and monitoring of disease progression. The clinical relevance of Nectin-4 is underscored by the Food and Drug Administration's approval of enfortumab vedotin (EV), the first antibody-drug conjugate targeting this protein, for the treatment of urothelial carcinoma. Ongoing clinical trials are expanding the therapeutic applications of EV, highlighting the critical role of Nectin-4 in targeted cancer therapy. Furthermore, novel therapeutic agents targeting Nectin-4 are under investigation, offering potential new avenues for cancer treatment. Despite these advancements, the precise molecular mechanisms by which Nectin-4 influences carcinogenesis and tumor progression remain inadequately understood. Challenges such as therapy-related adverse effects and the development of drug resistance further complicate the clinical management of Nectin-4-associated cancers. This review investigates the molecular functions of Nectin-4, emphasizing its diagnostic and prognostic value in cancer. We also explore the landscape of novel drug discoveries targeting Nectin-4 and provide an overview of current clinical trials aimed at utilizing this marker for therapeutic interventions. By elucidating the multifaceted role of Nectin-4 in malignancies, this article aims to advance our understanding and improve the clinical outcomes for patients with Nectin-4 overexpressing tumors.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"391 ","pages":"223-255"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiome and tumor immunotherapy. 肠道微生物组与肿瘤免疫治疗。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-22 DOI: 10.1016/bs.ircmb.2024.12.014

Mohini Vig, Shweta Dubey

引用次数: 0

Expanding frontiers in liquid biopsy-discovery and validation of circulating biomarkers in renal cell carcinoma and bladder cancer. 拓展液体活检的前沿：肾细胞癌和膀胱癌循环生物标志物的发现和验证。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2024-09-12 DOI: 10.1016/bs.ircmb.2024.08.005

Sabareeswaran Krishnan, Shruthi Kanthaje, Punchappady Devasya Rekha, M Mujeeburahiman, Chandrahas Koumar Ratnacaram

{"title":"Expanding frontiers in liquid biopsy-discovery and validation of circulating biomarkers in renal cell carcinoma and bladder cancer.","authors":"Sabareeswaran Krishnan, Shruthi Kanthaje, Punchappady Devasya Rekha, M Mujeeburahiman, Chandrahas Koumar Ratnacaram","doi":"10.1016/bs.ircmb.2024.08.005","DOIUrl":"10.1016/bs.ircmb.2024.08.005","url":null,"abstract":"Renal cell carcinoma (RCC) and Bladder cancer (BC) are two lethal urological cancers that require diagnosis at their earliest stage causing decreasing survival rates in case of aggressive disease. However, there is no reliable circulating marker in blood or urine for their less or non-invasive diagnosis. Our objective was to review the potential circulating biomarkers, namely proteins, micro-RNA (miRNA), long non-coding RNA (lncRNA), and circulating tumour cells (CTCs) for which we performed a PubMed-based literature search of biomolecules (protein, miRNA, lncRNA and CTCs) found as circulating biomarkers in blood and urine for the early detection of RCC and BC. Among the numerous studies, certain biomolecules represent promising early-stage biomarkers such as proteins (NNMT, LCP1, and NM23A; KIM1), mi-RNAs (5-panel: miR-193a-3p, miR-362, miR-572, miR-378, and miR-28-5p; miR-200a) and lncRNAs (5-panel: LET, PVT1, PANDAR, PTENP1 and linc00963; GIHCG) for RCC. Similarly, proteins (APOA1), miRNAs (7-panel: miR-7-5p, miR-22-3p, miR-29a-3p, miR-126-5p, miR- 200a-3p, miR-375, and miR-423-5p; miRNA 181a, miRNA 30c, and miRNA 570) and lncRNAs (3-panel: MALAT1, MEG3, and SNHG16; exosomal derived 3-panel: PCAT-1, UBC1 and SNHG16; H19) were reported in BC subjects. Notably, the majority of the biomarkers presented for early detection in RCC cases were found in blood, while in urine for BC. Our results reveal that though a plethora of circulating biomarkers show early diagnostic ability, all of them are still bench-only biomarkers and require further validation. Adequate clinical trials/studies testing which of these potential markers individually or in combination, will become clinically applicable still remain elusive.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"391 ","pages":"135-197"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0