International review of cell and molecular biology最新文献_第4页

Recent advances in nanomedicine as drug delivery system. 纳米药物作为给药系统的研究进展。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2026-02-05 DOI: 10.1016/bs.ircmb.2025.12.005

Minh-Dat Quoc Tang, Bao-Nhien Au, Van Khanh Hoang, Long Binh Vong

引用次数: 0

Autophagy and primary cilium: A dynamic duo in cellular homeostasis and disease. 自噬和初级纤毛：细胞内稳态和疾病的动态二人组。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-09-19 DOI: 10.1016/bs.ircmb.2025.08.005

Javiera Acevedo-Valdivieso, Camila Sandoval-Valenzuela, Daniela Pinto-Núñez, Isidora Reyes-Risso, Yorka Cheuquemilla, Diego Acuña-Catalán, Patricia V Burgos, Eugenia Morselli

{"title":"Autophagy and primary cilium: A dynamic duo in cellular homeostasis and disease.","authors":"Javiera Acevedo-Valdivieso, Camila Sandoval-Valenzuela, Daniela Pinto-Núñez, Isidora Reyes-Risso, Yorka Cheuquemilla, Diego Acuña-Catalán, Patricia V Burgos, Eugenia Morselli","doi":"10.1016/bs.ircmb.2025.08.005","DOIUrl":"10.1016/bs.ircmb.2025.08.005","url":null,"abstract":"The primary cilium (PC) is a microtubule-based organelle that functions as a signaling hub, coordinating critical cellular processes and maintaining cell homeostasis. Autophagy, a lysosome-mediated degradation pathway, has emerged as a key regulator of PC dynamics, which are crucial to control PC function. Ciliophagy, the selective autophagic degradation of damaged ciliary components, controls PC homeostasis ensuring PC integrity and function. This review highlights the intricate bidirectional crosstalk between the PC and autophagy, which influences cellular responses to environmental cues, nutrient availability, and hormonal signaling. Disruption of ciliophagy impairs PC-dependent signaling, contributing to the development of diseases such as ciliopathies and metabolic syndrome, among others. Furthermore, the overlap between ciliopathies and autophagy-related disorders underscores the crucial role of their interplay in health and disease. Recent evidence suggests that pharmacological modulation of autophagy could restore PC homeostasis, offering therapeutic potential for ciliopathies and other PC-associated diseases. Future research should focus on elucidating the molecular mechanisms driving ciliophagy in specific cell-types and exploring its therapeutic implications for clinical applications.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"403 ","pages":"1-28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology, biological models and new therapeutic approaches in β-Propeller Associated Neurodegeneration. β-螺旋桨相关性神经变性的病理生理学、生物学模型和新的治疗方法。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1016/bs.ircmb.2025.10.004

Ana Romero-González, Diana Reche-López, Mónica Álvarez-Córdoba, Alejandra Suárez-Carrillo, Paula Cilleros-Holgado, Rocío Piñero-Pérez, David Gómez-Fernández, José Manuel Romero-Domínguez, Alejandra López-Cabrera, José A Sánchez-Alcázar

{"title":"Pathophysiology, biological models and new therapeutic approaches in β-Propeller Associated Neurodegeneration.","authors":"Ana Romero-González, Diana Reche-López, Mónica Álvarez-Córdoba, Alejandra Suárez-Carrillo, Paula Cilleros-Holgado, Rocío Piñero-Pérez, David Gómez-Fernández, José Manuel Romero-Domínguez, Alejandra López-Cabrera, José A Sánchez-Alcázar","doi":"10.1016/bs.ircmb.2025.10.004","DOIUrl":"10.1016/bs.ircmb.2025.10.004","url":null,"abstract":"Neurodegeneration with brain iron accumulation (NBIA) encompasses a set of rare disorders that present a diagnostic challenge due to their genetic and clinical diversity, with treatment options currently limited to symptom alleviation. One subtype, β-Propeller Associated Neurodegeneration (BPAN), results from pathogenic variants in the WDR45 gene on the X chromosome. This condition is marked by iron accumulation in the globus pallidus and substantia nigra, alongside early onset developmental delays, seizures, and motor impairments. The WDR45 gene produces the WDR45 protein, which plays a key role in the creation and maturation of autophagosomes-crucial components of the autophagy process, a cellular mechanism vital to the organism's proper function. In BPAN, reduced autophagy correlates with mitochondrial dysfunction, impaired antioxidant defenses, elevated lipid peroxidation, buildup of lipofuscin granules, and disrupted iron metabolism. However, the precise relationships between these pathological issues remain unclear. There is no curative treatment for BPAN, therefore care focuses on palliation and symptom management through a multidisciplinary approach. Nonetheless, research into various therapeutic strategies is ongoing, including gene therapy to correct the genetic anomaly and methods to influence pathological pathways like autophagy deficiency, lipid peroxidation, and iron accumulation. A novel approach has recently been suggested, aimed at reactivating the inactive X chromosome in females with BPAN.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"404 ","pages":"135-196"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eat, Heal, Repeat: How zebrafish master regeneration. 吃，治疗，重复：斑马鱼如何掌握再生。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-11-11 DOI: 10.1016/bs.ircmb.2025.10.008

Cristina Pérez-Montes, Elena Lavado-Fernández, Inés Martínez-Rojo, Adrián Santos-Ledo, Marina García-Macia

{"title":"Eat, Heal, Repeat: How zebrafish master regeneration.","authors":"Cristina Pérez-Montes, Elena Lavado-Fernández, Inés Martínez-Rojo, Adrián Santos-Ledo, Marina García-Macia","doi":"10.1016/bs.ircmb.2025.10.008","DOIUrl":"10.1016/bs.ircmb.2025.10.008","url":null,"abstract":"For eukaryotic organisms the maintenance and regulation of cellular homeostasis is essential. This process requires continuous elimination of cellular debris, including misfolded, oxidized, and aggregated proteins, and damaged/obsolete organelle. It also requires the remodelling of the cytoplasm compartments, and the provision of nutrients to support basic cellular functions. One of the central molecular mechanisms that maintain this precarious homeostasis is the recycling program of the cell: autophagy. Dysregulation of autophagy has a relationship with several diseases, including neurodegeneration, metabolic diseases, age-related disorders, heart dysfunction, cancer, and inflammatory diseases. The regeneration of some tissues and organs in humans is limited, which hinders our capacity to recover from diseases. Regenerative ability varies from species, organs, tissues, and development stages. Whereas mammals have a more limited regenerative capacity, restricted to few tissues or organs, such as skin or liver, other vertebrates, such as axolotls, salamanders, goldfish and zebrafish, possess a higher regenerative capacity. Zebrafish display exceptional regenerative abilities. Both embryo and adult zebrafish can regenerate organs like the fin, heart, liver, kidney, muscle, spinal cord, retina and optic nerves, and several brain regions. In recent years, several works remark the crucial role of autophagy in the repair of damaged tissues and the replacement of impaired organs or body parts after injury. Investigating the cellular function of autophagy in regenerative processes will allow us to develop new therapeutic strategies for human disorders. In this chapter, we discuss the current evidence supporting the important role of autophagy in mediating regenerative processes, emphasizing the relevance of zebrafish as a prominent vertebrate model to study autophagy.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"404 ","pages":"81-134"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemicals with epigenetic properties and their role in melanoma therapy. 具有表观遗传特性的植物化学物质及其在黑色素瘤治疗中的作用。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2024-12-07 DOI: 10.1016/bs.ircmb.2024.12.001

Ioannis Anestopoulos, Sotiris Kyriakou, Maria V Deligiorgi, Dimitrios T Trafalis, Sotiris Botaitis, Alexandra N Giatromanolaki, Rodrigo Franco, Michael I Koukourakis, Aglaia Pappa, Mihalis I Panayiotidis

{"title":"Phytochemicals with epigenetic properties and their role in melanoma therapy.","authors":"Ioannis Anestopoulos, Sotiris Kyriakou, Maria V Deligiorgi, Dimitrios T Trafalis, Sotiris Botaitis, Alexandra N Giatromanolaki, Rodrigo Franco, Michael I Koukourakis, Aglaia Pappa, Mihalis I Panayiotidis","doi":"10.1016/bs.ircmb.2024.12.001","DOIUrl":"10.1016/bs.ircmb.2024.12.001","url":null,"abstract":"Malignant melanoma is the most aggressive and lethal type of skin cancer associated with increased mortality rates. Moreover, beyond the genetic background, the altered epigenetic landscape (e.g., abnormal patterns of DNA methylation, aberrant histone modifications and de-regulated expression levels of ncRNAs) further contributes to the pathophysiology of the disease. In addition, despite the improvement of current anti-melanoma strategies and the development of new therapeutic approaches, the 5-year survival among melanoma patients is still high, mainly due to acquired-drug resistance. On the other hand, phytochemicals have been associated with various health-promoting properties through pleiotropic mechanisms including acting as potent epigenetic regulators restoring back a normal phenotype in various experimental cancer models. In this review article, we discuss the general characteristics of malignant melanoma and current therapeutic approaches while we report the epigenetic basis of the disease along with the main compounds capable of restoring a normal epigenetic landscape. Finally, we describe the role of various phytochemicals in targeting the epigenome of malignant melanoma thereby potentially acting as an alternative therapeutic approach.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"400 ","pages":"1-30"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147573909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral trafficking: The role of autophagy in the release of virus-loaded extracellular vesicles. 病毒运输：自噬在载病毒细胞外囊泡释放中的作用。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-12-15 DOI: 10.1016/bs.ircmb.2025.12.002

Laura Vipraio Tiberi, Angelica Di Matteo, Fatima Domenica Elisa De Palma, Manuela Lizarralde-Guerrero, Mojgan Djavaheri-Mergny, Maria Vitale, Filippo Scialó, Lucio Pastore, Maria Chiara Maiuri, Jonathan Pol

{"title":"Viral trafficking: The role of autophagy in the release of virus-loaded extracellular vesicles.","authors":"Laura Vipraio Tiberi, Angelica Di Matteo, Fatima Domenica Elisa De Palma, Manuela Lizarralde-Guerrero, Mojgan Djavaheri-Mergny, Maria Vitale, Filippo Scialó, Lucio Pastore, Maria Chiara Maiuri, Jonathan Pol","doi":"10.1016/bs.ircmb.2025.12.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2025.12.002","url":null,"abstract":"Over the past decade, the interplay between autophagy process and viral replication, alongside the mechanisms by which viruses evade immune surveillance, has been extensively investigated. Increasing evidence indicates that viruses hijack the autophagic machinery to facilitate the release of extracellular vesicles (EVs) carrying viral components. This involvement highlights autophagy as a central hub in viral trafficking, bridging intracellular remodelling with extracellular dissemination. In this review, we explore how viruses exploit autophagy and EV pathways to promote replication and enable non-lytic release. We highlight the molecular interactions underlying EV biogenesis and secretory autophagy and discuss the emerging potential of EVs as biomarkers and therapeutic platforms, despite current technical challenges. Finally, we examine strategies to target the autophagy-EV interface as an antiviral strategy.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"406 ","pages":"165-211"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The synergy of foundation technologies and computer sciences advances microbial expression systems in biomedical genetic engineering. 基础技术和计算机科学的协同作用推进生物医学基因工程中的微生物表达系统。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-12-08 DOI: 10.1016/bs.ircmb.2025.11.007

Le Khanh Nguyen, Diep Thi Hoang, Stephane Jouannic

引用次数: 0

Extracellular vesicles as dynamic biomarkers: Monitoring therapeutic responses and drug resistance in cancer. 细胞外囊泡作为动态生物标志物：监测癌症的治疗反应和耐药性。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-02-28 DOI: 10.1016/bs.ircmb.2025.01.006

Shaimaa A Gouhar, Zakaria Y Abd Elmageed, Sherien M El-Daly

{"title":"Extracellular vesicles as dynamic biomarkers: Monitoring therapeutic responses and drug resistance in cancer.","authors":"Shaimaa A Gouhar, Zakaria Y Abd Elmageed, Sherien M El-Daly","doi":"10.1016/bs.ircmb.2025.01.006","DOIUrl":"10.1016/bs.ircmb.2025.01.006","url":null,"abstract":"Cancer remains a major health challenge, with traditional monitoring approaches that are often limited in sensitivity and invasiveness. Liquid biopsies, particularly those involving circulating extracellular vesicles (EVs), have emerged as a promising non-invasive approach that holds efficient diagnostic and prognostic value, predicting disease development and patient outcomes. Furthermore, EVs can monitor therapy responses and detect potential resistance development. In this review, we delineate the diverse cargo within EVs, including proteins, lipids, RNAs, and DNA, and their potential implications for cancer progression. The clinical utilization of EVs as prognostic and treatment-monitoring biomarkers for various types of cancer is addressed in depth, with a focus on their ability to identify molecular signatures associated with drug resistance. We also present a comprehensive collection of studies on EV-derived biomarkers for monitoring treatment responses across various cancer types, as well as investigations into EV-derived biomarkers associated with therapeutic resistance. While the promise of EV biomarkers in cancer therapy monitoring is acknowledged, we also discuss in detail the existing challenges and future directions in this research area. This review ultimately improves our understanding of liquid biopsies, specifically EV biomarkers, paving the way for more personalized and effective dynamic biomarkers.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"399 ","pages":"43-112"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating biomarkers for diagnosis, prognosis, and treatment response prediction in cancer. 用于癌症诊断、预后和治疗反应预测的循环生物标志物。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 DOI: 10.1016/S1937-6448(26)00017-1

Sheila Spada, Lorenzo Galluzzi

引用次数: 0

Epigenetic regulation of autophagy in cancer: A double-edged sword in tumor progression and therapy resistance. 肿瘤自噬的表观遗传调控：肿瘤进展和治疗耐药的双刃剑。

3区生物学

International review of cell and molecular biology Pub Date : 2026-01-01 Epub Date: 2025-09-09 DOI: 10.1016/bs.ircmb.2025.08.002

Amir Barzegar Behrooz, Marco Cordani, Saeid Ghavami

{"title":"Epigenetic regulation of autophagy in cancer: A double-edged sword in tumor progression and therapy resistance.","authors":"Amir Barzegar Behrooz, Marco Cordani, Saeid Ghavami","doi":"10.1016/bs.ircmb.2025.08.002","DOIUrl":"10.1016/bs.ircmb.2025.08.002","url":null,"abstract":"Cancer progression is governed by a dynamic interplay between genetic alterations and epigenetic modifications, which shape tumor adaptation, immune evasion, and therapy resistance. Among these modifications, epigenetic regulation of autophagy, a cellular process critical for maintaining homeostasis, has emerged as a key player in cancer biology. While autophagy suppresses tumor initiation by eliminating damaged organelles and reducing oxidative stress, tumors can hijack this process to sustain survival under metabolic stress and promote resistance to chemotherapy, radiotherapy, and immunotherapy. This review explores the intricate crosstalk between DNA methylation, histone modifications, and non-coding RNAs in controlling autophagy-related genes and their dual role in cancer progression. We also highlight the therapeutic potential of targeting epigenetic modulators (HDAC and DNMT inhibitors) and autophagy regulators to overcome multidrug resistance. Understanding the epigenetic-autophagy axis provides novel insights into cancer treatment, emphasizing the need for personalized approaches that balance autophagic activity to enhance therapy efficacy and improve patient outcomes. This emerging field presents a promising frontier for epigenetic-driven precision medicine in oncology.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"400 ","pages":"63-105"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147573076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0