International review of cell and molecular biology最新文献_第5页

Epigenetic inhibitors for cancer treatment. 用于治疗癌症的表观遗传抑制剂。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2023-07-18 DOI: 10.1016/bs.ircmb.2023.06.003

Hongchao Yuan, Yuanjun Lu, Yibin Feng, Ning Wang

引用次数: 0

Therapeutic potential of hedgehog signaling in advanced cancer types. 刺猬信号在晚期癌症类型中的治疗潜力。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.1016/bs.ircmb.2024.01.003

Richa Singh, Anindita Ray

{"title":"Therapeutic potential of hedgehog signaling in advanced cancer types.","authors":"Richa Singh, Anindita Ray","doi":"10.1016/bs.ircmb.2024.01.003","DOIUrl":"10.1016/bs.ircmb.2024.01.003","url":null,"abstract":"In this chapter, we have made an attempt to elucidate the relevance of hedgehog signaling pathway in tumorigenesis. Here, we have described different types of hedgehog signaling (canonical and non-canonical) with emphasis on the different mechanisms (mutation-driven, autocrine, paracrine and reverse paracrine) it adopts during tumorigenesis. We have discussed the role of hedgehog signaling in regulating cell proliferation, invasion and epithelial-to-mesenchymal transition in both local and advanced cancer types, as reported in different studies based on preclinical and clinical models. We have specifically addressed the role of hedgehog signaling in aggressive neuroendocrine tumors as well. We have also elaborated on the studies showing therapeutic relevance of the inhibitors of hedgehog signaling in cancer. Evidence of the crosstalk of hedgehog signaling components with other signaling pathways and treatment resistance due to tumor heterogeneity have also been briefly discussed. Together, we have tried to put forward a compilation of the studies on therapeutic potential of hedgehog signaling in various cancers, specifically aggressive tumor types with a perspective into what is lacking and demands further investigation.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"386 ","pages":"49-80"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-generation deconvolution of transcriptomic data to investigate the tumor microenvironment. 下一代转录组数据解卷积研究肿瘤微环境。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2023-06-21 DOI: 10.1016/bs.ircmb.2023.05.002

Lorenzo Merotto, Maria Zopoglou, Constantin Zackl, Francesca Finotello

引用次数: 0

Epigenetic contribution to cancer. 表观遗传对癌症的影响

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-06-19 DOI: 10.1016/bs.ircmb.2024.05.003

Songhua Quan, Hao Huang

{"title":"Epigenetic contribution to cancer.","authors":"Songhua Quan, Hao Huang","doi":"10.1016/bs.ircmb.2024.05.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.05.003","url":null,"abstract":"Epigenetics has transformed our understanding of cancer by revealing how changes in gene activity, which do not alter the DNA itself, can initiate and progress the disease. These changes include adjustments in DNA methylation, histone configuration, and non-coding RNA activity. For instance, DNA methylation can inactivate genes that typically protect against cancer, leading to broader genomic instability. Histone modifications can alter how tightly DNA is wound, influencing which genes are active or silenced; while non-coding RNAs can interfere with the messages that direct protein production, impacting cancer-related processes. Unlike genetic mutations, which are permanent and irreversible, epigenetic changes provide a malleable target for therapeutic intervention, allowing potentially reversible adjustments to gene expression patterns. This flexibility is essential in the complex landscape of cancer where static genetic solutions may be insufficient. Additionally, epigenetics bridges the gap between genetic predispositions and environmental influences on cancer, offering a comprehensive framework for understanding how lifestyle factors and external exposures impact cancer risk and progression. The integration of epigenetics into cancer research not only enhances our understanding of the disease but also opens innovative avenues for intervention that were previously unexplored in traditional genetic-focused studies. Technologies like advanced sequencing and precise epigenetic modification are paving the way for early cancer detection and more personalized treatment approaches, highlighting the critical role of epigenetics in modern cancer care.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"387 ","pages":"1-25"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifaceted perspectives of detecting and targeting solid tumors. 检测和靶向实体瘤的多角度视角。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-06-01 DOI: 10.1016/bs.ircmb.2024.03.010

Abhishek Bhattacharya, Anjan Kr Dasgupta

{"title":"Multifaceted perspectives of detecting and targeting solid tumors.","authors":"Abhishek Bhattacharya, Anjan Kr Dasgupta","doi":"10.1016/bs.ircmb.2024.03.010","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.03.010","url":null,"abstract":"Solid tumors are the most prevalent form of cancer. Considerable technological and medical advancements had been achieved for the diagnosis of the disease. However, detection of the disease in an early stage is of utmost importance, still far from reality. On the contrary, the treatment and therapeutic area to combat solid tumors are still in its infancy. Conventional treatments like chemotherapy and radiation therapy pose challenges due to their indiscriminate impact on healthy and cancerous cells. Contextually, efficient drug targeting is a pivotal approach in solid tumor treatment. This involves the precise delivery of drugs to cancer cells while minimizing harm to healthy cells. Targeted drugs exhibit superior efficacy in eradicating cancer cells while impeding tumor growth and mitigate side effects by optimizing absorption which further diminishes the risk of resistance. Furthermore, tailoring targeted therapies to a patient's tumor-specific molecular profile augments treatment efficacy and reduces the likelihood of relapse. This chapter discuss about the distinctive characteristics of solid tumors, the possibility of early detection of the disease and potential therapeutic angle beyond the conventional approaches. Additionally, the chapter delves into a hitherto unknown attribute of magnetic field effect to target cancer cells which exploit the relatively less susceptibility of normal cells compared to cancer cells to magnetic fields, suggesting a future potential of magnetic nanoparticles for selective cancer cell destruction. Lastly, bioinformatics tools and other unconventional methodologies such as AI-assisted codon bias analysis have a crucial role in comprehending tumor biology, aiding in the identification of futuristic targeted therapies.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"389 ","pages":"1-66"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic contribution to the relationship between obesity and cancer. 表观遗传学对肥胖与癌症之间关系的贡献。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-05-14 DOI: 10.1016/bs.ircmb.2024.03.007

Yen-Vy Nguyen Thi, Thuy-Duong Vu, Nguyen Thi Lan Huong, Dinh-Toi Chu

{"title":"Epigenetic contribution to the relationship between obesity and cancer.","authors":"Yen-Vy Nguyen Thi, Thuy-Duong Vu, Nguyen Thi Lan Huong, Dinh-Toi Chu","doi":"10.1016/bs.ircmb.2024.03.007","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.03.007","url":null,"abstract":"Obesity and cancer are two major health issues all around the world due to their elevated prevalence. Several experimental and epidemiological studies have demonstrated the relationship between obesity and cancer, in which obesity is considered a risk factor for cancer development. The ultimate goal of knowing the epigenetic contribution to the relationship between obesity and cancer is to find the method of intervention or treatment of obesity and cancer. Therefore, providing the most general perspective on epigenetic contribution to the relationship between obesity and cancer is necessary. Obesity is closely related to some common cancers that are currently encountered, including breast, esophagus, liver, kidney, uterus, colorectal, pancreatic, and gallbladder. Obesity has a significant impact that increases the risk of cancer deaths and thereby indirectly affects the choice of treatment. It is estimated that about 4-8% of cancer cases are caused by obesity. In particular, the basic mechanism to understand the relationship between cancer is very complicated and has not been fully understood. This work is aimed at summarizing the current knowledge of the role of epigenetic regulation in the relationship between obesity, and potential applications.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"387 ","pages":"195-213"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory breast cancer: As surgical oncologists, what can we do? 炎症性乳腺癌：作为外科肿瘤学家，我们能做些什么？

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-03-28 DOI: 10.1016/bs.ircmb.2024.02.004

Hatem Bouzaiene, Fatma Saadallah, Hanen Bouaziz, Olfa Jaidane, Jamel Ben Hassouna, Tarak Dhieb, Khaled Rahal

{"title":"Inflammatory breast cancer: As surgical oncologists, what can we do?","authors":"Hatem Bouzaiene, Fatma Saadallah, Hanen Bouaziz, Olfa Jaidane, Jamel Ben Hassouna, Tarak Dhieb, Khaled Rahal","doi":"10.1016/bs.ircmb.2024.02.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.02.004","url":null,"abstract":"Breast cancer surgery is the primary treatment for early-stage breast cancer. However, inflammatory breast cancer (IBC), with its specific presentation characterized by skin invasion, is unfit for primary surgery. According to the different guidelines, the management of IBC is trimodal with the coordination of oncologists, surgeons, and radiation therapists. Advances in breast cancer imaging and the development of more targeted therapies make new challenges for this aggressive cancer. This chapter aims to provide an update on the role of surgery in IBC. Radical surgery is still considered the standard surgical treatment in IBC. Some authors suggest a conservative surgery in patients with a clinical response to chemotherapy without affecting survival. For lymph node surgery, the sentinel lymph node biopsy (SLNB) is not feasible in IBC patients, according to the existing studies. However, prospective studies on SLNB are needed to verify its reliability after chemotherapy for a specific group of patients. In the metastatic IBC, surgery can be considered if there is a good response after chemotherapy or for uncontrolled symptoms. Existing studies showed that surgery may impact survival for these patients. Prospective studies are mandatory to optimize IBC management, considering factors such as tumor's molecular profile.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"384 ","pages":"113-124"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in targets in inflammatory breast cancer. 炎症性乳腺癌靶点研究进展。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI: 10.1016/bs.ircmb.2023.10.005

Toshiaki Iwase, Xiaoping Wang, Lan Thi Hanh Phi, Nithya Sridhar, Naoto T Ueno, Jangsoon Lee

引用次数: 0

Exploring TLR signaling pathways as promising targets in cervical cancer: The road less traveled. 将 TLR 信号通路作为宫颈癌的有望靶点进行探索：少有人走的路

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-01-12 DOI: 10.1016/bs.ircmb.2023.11.005

Mohini Agarwal, Manish Kumar, Rajiv Pathak, Kumud Bala, Anoop Kumar

{"title":"Exploring TLR signaling pathways as promising targets in cervical cancer: The road less traveled.","authors":"Mohini Agarwal, Manish Kumar, Rajiv Pathak, Kumud Bala, Anoop Kumar","doi":"10.1016/bs.ircmb.2023.11.005","DOIUrl":"10.1016/bs.ircmb.2023.11.005","url":null,"abstract":"Cervical cancer is the leading cause of cancer-related deaths for women globally. Despite notable advancements in prevention and treatment, the identification of novel therapeutic targets remains crucial for cervical cancer. Toll-like receptors (TLRs) play an essential role in innate immunity as pattern-recognition receptors. There are several types of pathogen-associated molecular patterns (PAMPs), including those present in cervical cancer cells, which have the ability to activate toll-like receptors (TLRs). Recent studies have revealed dysregulated toll-like receptor (TLR) signaling pathways in cervical cancer, leading to the production of inflammatory cytokines and chemokines that can facilitate tumor growth and metastasis. Consequently, TLRs hold significant promise as potential targets for innovative therapeutic agents against cervical cancer. This book chapter explores the role of TLR signaling pathways in cervical cancer, highlighting their potential for targeted therapy while addressing challenges such as tumor heterogeneity and off-target effects. Despite these obstacles, targeting TLR signaling pathways presents a promising approach for the development of novel and effective treatments for cervical cancer.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"385 ","pages":"227-261"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria driven innate immune signaling and inflammation in cancer growth, immune evasion, and therapeutic resistance. 线粒体驱动的先天性免疫信号传导和炎症在癌症生长、免疫逃避和治疗抵抗中的作用。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-03-13 DOI: 10.1016/bs.ircmb.2024.01.006

Sanjay Pandey, Vandana Anang, Michelle M Schumacher

{"title":"Mitochondria driven innate immune signaling and inflammation in cancer growth, immune evasion, and therapeutic resistance.","authors":"Sanjay Pandey, Vandana Anang, Michelle M Schumacher","doi":"10.1016/bs.ircmb.2024.01.006","DOIUrl":"10.1016/bs.ircmb.2024.01.006","url":null,"abstract":"Mitochondria play an important and multifaceted role in cellular function, catering to the cell's energy and biosynthetic requirements. They modulate apoptosis while responding to diverse extracellular and intracellular stresses including reactive oxygen species (ROS), nutrient and oxygen scarcity, endoplasmic reticulum stress, and signaling via surface death receptors. Integral components of mitochondria, such as mitochondrial DNA (mtDNA), mitochondrial RNA (mtRNA), Adenosine triphosphate (ATP), cardiolipin, and formyl peptides serve as major damage-associated molecular patterns (DAMPs). These molecules activate multiple innate immune pathways both in the cytosol [such as Retionoic Acid-Inducible Gene-1 (RIG-1) and Cyclic GMP-AMP Synthase (cGAS)] and on the cell surface [including Toll-like receptors (TLRs)]. This activation cascade leads to the release of various cytokines, chemokines, interferons, and other inflammatory molecules and oxidative species. The innate immune pathways further induce chronic inflammation in the tumor microenvironment which either promotes survival and proliferation or promotes epithelial to mesenchymal transition (EMT), metastasis and therapeutic resistance in the cancer cell's. Chronic activation of innate inflammatory pathways in tumors also drives immunosuppressive checkpoint expression in the cancer cells and boosts the influx of immune-suppressive populations like Myeloid-Derived Suppressor Cells (MDSCs) and Regulatory T cells (Tregs) in cancer. Thus, sensing of cellular stress by the mitochondria may lead to enhanced tumor growth. In addition to that, the tumor microenvironment also becomes a source of immunosuppressive cytokines. These cytokines exert a debilitating effect on the functioning of immune effector cells, and thus foster immune tolerance and facilitate immune evasion. Here we describe how alteration of the mitochondrial homeostasis and cellular stress drives innate inflammatory pathways in the tumor microenvironment.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"386 ","pages":"223-247"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0