International review of cell and molecular biology最新文献

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Immune checkpoint biology in health & disease: Immune checkpoint biology and autoimmunity in cancer patients. 健康与疾病中的免疫检查点生物学:免疫检查点生物学与癌症患者的自身免疫。
3区 生物学
International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2023-05-24 DOI: 10.1016/bs.ircmb.2023.04.003
Pierre Van Mol, Elena Donders, Diether Lambrechts, Els Wauters
{"title":"Immune checkpoint biology in health & disease: Immune checkpoint biology and autoimmunity in cancer patients.","authors":"Pierre Van Mol, Elena Donders, Diether Lambrechts, Els Wauters","doi":"10.1016/bs.ircmb.2023.04.003","DOIUrl":"10.1016/bs.ircmb.2023.04.003","url":null,"abstract":"<p><p>Immune checkpoints (ICs) play a central role in maintaining immune homoeostasis. The discovery that tumours use this physiological mechanism to avoid elimination by the immune system, opened up avenues for therapeutic targeting of ICs as a novel way of treating cancer. However, this therapy a new array of autoimmune side effects, termed immune-related adverse events (irAEs). In this narrative review, we first recapitulate the physiological function of ICs that are approved targets for cancer immunotherapy (CTLA-4, PD-(L)1 and LAG-3), as the groundwork to critically discuss current knowledge on irAEs. Specifically, we summarize clinical aspects and examine a molecular classification and predisposing factors of irAEs. Finally, we discuss irAE treatment, particularly emphasizing how molecular knowledge is changing the current treatment paradigm.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"382 ","pages":"181-206"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139471849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel technologies for applying immune checkpoint blockers. 应用免疫检查点阻断剂的新技术。
3区 生物学
International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2023-03-30 DOI: 10.1016/bs.ircmb.2023.03.003
Robin Maximilian Awad, Karine Breckpot
{"title":"Novel technologies for applying immune checkpoint blockers.","authors":"Robin Maximilian Awad, Karine Breckpot","doi":"10.1016/bs.ircmb.2023.03.003","DOIUrl":"10.1016/bs.ircmb.2023.03.003","url":null,"abstract":"<p><p>Cancer cells develop several ways to subdue the immune system among others via upregulation of inhibitory immune checkpoint (ICP) proteins. These ICPs paralyze immune effector cells and thereby enable unfettered tumor growth. Monoclonal antibodies (mAbs) that block ICPs can prevent immune exhaustion. Due to their outstanding effects, mAbs revolutionized the field of cancer immunotherapy. However, current ICP therapy regimens suffer from issues related to systemic administration of mAbs, including the onset of immune related adverse events, poor pharmacokinetics, limited tumor accessibility and immunogenicity. These drawbacks and new insights on spatiality prompted the exploration of novel administration routes for mAbs for instance peritumoral delivery. Moreover, novel ICP drug classes that are adept to novel delivery technologies were developed to circumvent the drawbacks of mAbs. We therefore review the state-of-the-art and novel delivery strategies of ICP drugs.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"382 ","pages":"1-101"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenome editing in cancer: Advances and challenges for potential therapeutic options. 癌症中的表观基因组编辑:潜在治疗方案的进展与挑战。
3区 生物学
International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2023-11-21 DOI: 10.1016/bs.ircmb.2023.10.001
Seung-Won Lee, Connor Mitchell Frankston, Jungsun Kim
{"title":"Epigenome editing in cancer: Advances and challenges for potential therapeutic options.","authors":"Seung-Won Lee, Connor Mitchell Frankston, Jungsun Kim","doi":"10.1016/bs.ircmb.2023.10.001","DOIUrl":"10.1016/bs.ircmb.2023.10.001","url":null,"abstract":"<p><p>Cancers are diseases caused by genetic and non-genetic environmental factors. Epigenetic alterations, some attributed to non-genetic factors, can lead to cancer development. Epigenetic changes can occur in tumor suppressors or oncogenes, or they may contribute to global cell state changes, making cells abnormal. Recent advances in gene editing technology show potential for cancer treatment. Herein, we will discuss our current knowledge of epigenetic alterations occurring in cancer and epigenetic editing technologies that can be applied to developing therapeutic options.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"383 ","pages":"191-230"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139741000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic alterations in AML: Deregulated functions leading to new therapeutic options. 急性髓细胞性白血病的表观遗传学改变:功能失调带来新的治疗方案。
3区 生物学
International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-07-09 DOI: 10.1016/bs.ircmb.2024.06.003
Kourosh Hayatigolkhatmi, Riccardo Valzelli, Oualid El Menna, Saverio Minucci
{"title":"Epigenetic alterations in AML: Deregulated functions leading to new therapeutic options.","authors":"Kourosh Hayatigolkhatmi, Riccardo Valzelli, Oualid El Menna, Saverio Minucci","doi":"10.1016/bs.ircmb.2024.06.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.06.003","url":null,"abstract":"<p><p>Acute myeloid leukemia (AML) results in disruption of the hematopoietic differentiation process. Crucial progress has been made, and new therapeutic strategies for AML have been developed. Induction chemotherapy, however, remains the main option for the majority of AML patients. Epigenetic dysregulation plays a central role in AML pathogenesis, supporting leukemogenesis and maintenance of leukemic stem cells. Here, we provide an overview of the intricate interplay of altered epigenetic mechanisms, including DNA methylation, histone modifications, and chromatin remodeling, in AML development. We explore the role of epigenetic regulators, such as DNMTs, HMTs, KDMs, and HDACs, in mediating gene expression patterns pushing towards leukemic cell transformation. Additionally, we discuss the impact of cytogenetic lesions on epigenomic remodeling and the potential of targeting epigenetic vulnerabilities as a therapeutic strategy. Understanding the epigenetic landscape of AML offers insights into novel therapeutic avenues, including epigenetic modifiers and particularly their use in combination therapies, to improve treatment outcomes and overcome drug resistance.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"387 ","pages":"27-75"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiation for inflammatory breast cancer: Updates. 炎症性乳腺癌的放射治疗:更新。
3区 生物学
International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2023-10-19 DOI: 10.1016/bs.ircmb.2023.10.004
Michael C Stauder
{"title":"Radiation for inflammatory breast cancer: Updates.","authors":"Michael C Stauder","doi":"10.1016/bs.ircmb.2023.10.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.10.004","url":null,"abstract":"<p><p>Inflammatory breast cancer (IBC) is a diagnosis based on a constellation of clinical features of edema (peau d'orange) of a third or more of the skin of the breast with a palpable border and a rapid onset of breast erythema. Incidence of IBC has increased over time, although it still makes up only 1-4% of all breast cancer diagnoses. Despite recent encouraging data on clinical outcomes, the published local-regional control rates remain consistently lower than the rates for non-IBC. In this review, we focus on radiotherapy, provide a framework for multi-disciplinary care for IBC, describe local-regional treatment techniques for IBC; highlight new directions in the management of patients with metastatic IBC and offer an introduction to future directions regarding the optimal treatment and management of IBC.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"384 ","pages":"25-46"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemotherapy to potentiate the radiation-induced immune response. 化疗以增强辐射诱导的免疫反应。
3区 生物学
International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.01.004
Benoît Lecoester, Mylène Wespiser, Amélie Marguier, Céline Mirjolet, Jihane Boustani, Olivier Adotévi
{"title":"Chemotherapy to potentiate the radiation-induced immune response.","authors":"Benoît Lecoester,&nbsp;Mylène Wespiser,&nbsp;Amélie Marguier,&nbsp;Céline Mirjolet,&nbsp;Jihane Boustani,&nbsp;Olivier Adotévi","doi":"10.1016/bs.ircmb.2023.01.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.01.004","url":null,"abstract":"<p><p>Chemoradiation (CRT) is a conventional therapy used in local cancers, especially when they are locally advanced. Studies have shown that CRT induces strong anti-tumor responses involving several immune effects in pre-clinical models and humans. In this review, we have described the various immune effects involved in CRT efficacy. Indeed, effects such as immunological cell death, activation and maturation of antigen-presenting cells, and activation of an adaptive anti-tumor immune response are attributed to CRT. As often described in other therapies, various immunosuppressive mechanisms mediated, in particular, by Treg and myeloid populations may reduce the CRT efficacy. We have therefore discussed the relevance of combining CRT with other therapies to potentiate the CRT-induced anti-tumor effects.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"376 ","pages":"143-173"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9452268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowing the myeloid-derived suppressor cells: Another enemy of sarcomas patients. 了解髓源性抑制细胞:肉瘤患者的另一个敌人。
3区 生物学
International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2022.11.003
Daniel J García-Domínguez, Víctor Sánchez-Margalet, Luis de la Cruz-Merino, Lourdes Hontecillas-Prieto
{"title":"Knowing the myeloid-derived suppressor cells: Another enemy of sarcomas patients.","authors":"Daniel J García-Domínguez,&nbsp;Víctor Sánchez-Margalet,&nbsp;Luis de la Cruz-Merino,&nbsp;Lourdes Hontecillas-Prieto","doi":"10.1016/bs.ircmb.2022.11.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2022.11.003","url":null,"abstract":"<p><p>Sarcomas are heterogeneous and aggressive malignant tumors with variable responses to current standard treatments being usually incurable for those patients with metastatic and unresectable diseases. The lack of curative strategies has led to develop new therapies in the treatment of sarcomas where the role of immune system is an evolving field. Most sarcomas often exhibit an immunosuppressive microenvironment, which reduces their capacity to trigger an immune response. Therefore, sarcomas are broadly considered as an \"immune cold\" tumor, although some studies have described a great immune heterogeneity across sarcoma subtypes. Sarcoma cells, like other tumors, evade their immune destruction through a variety of mechanisms, including expansion and recruitment of myeloid derived suppressor cells (MDSCs). MDSCs are immature myeloid cells that have been correlated with a reduction of the therapeutic efficacy, including immunotherapy, tumor progression and worst prognosis. Consequently, different strategies have been developed in recent years to target MDSCs in cancer treatments. This chapter discusses the role of MDSCs in sarcomas and their current potential as a therapeutic target in these malignancies.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"375 ","pages":"93-116"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9506631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloid-derived suppressor cells in head and neck squamous cell carcinoma. 头颈部鳞状细胞癌中的髓源性抑制细胞。
3区 生物学
International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2022.11.002
Jing-Yu He, Fang-Yi Huo, Hong-Chao Tang, Bing Liu, Lin-Lin Bu
{"title":"Myeloid-derived suppressor cells in head and neck squamous cell carcinoma.","authors":"Jing-Yu He,&nbsp;Fang-Yi Huo,&nbsp;Hong-Chao Tang,&nbsp;Bing Liu,&nbsp;Lin-Lin Bu","doi":"10.1016/bs.ircmb.2022.11.002","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2022.11.002","url":null,"abstract":"<p><p>Myeloid-derived suppressor cells (MDSCs), which originated from hematopoietic stem cells, are heterogeneous population of cells that have different differentiation patterns and widely presented in tumor microenvironment. For tumor research, myeloid suppressor cells have received extensive attention since their discovery due to their specific immunosuppressive properties, and the mechanisms of immunosuppression and therapeutic approaches for MDSCs have been investigated in a variety of different types of malignancies. To improve the efficacy of treatment for head and neck squamous cell carcinoma (HNSCC), a disease with a high occurrence, immunotherapy has gradually emerged in after traditional surgery and subsequent radiotherapy and chemotherapy, and has made some progress. In this review, we introduced the mechanisms on the development, differentiation, and elimination of MDSCs and provided a detailed overview of the mechanisms behind the immunosuppressive properties of MDSCs. We summarized the recent researches on MDSCs in HNSCC, especially for targeting-MDSCs therapy and combination with other types of therapy such as immune checkpoint blockade (ICB). Furthermore, we looked at drug delivery patterns and collected the current diverse drug delivery systems for the improvement that contributed to therapy against MDSCs in HNSCC. Most importantly, we made possible outlooks for the future research priorities, which provide a basis for further study on the clinical significance and therapeutic value of MDSCs in HNSCC.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"375 ","pages":"33-92"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9506633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Non-coding RNAs in the epigenetic landscape of cutaneous T-cell lymphoma. 非编码rna在皮肤t细胞淋巴瘤的表观遗传景观。
3区 生物学
International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.04.004
Monaza Adeeb, Lubna Therachiyil, Safwan Moton, Joerg Buddenkotte, Majid Ali Alam, Shahab Uddin, Martin Steinhoff, Aamir Ahmad
{"title":"Non-coding RNAs in the epigenetic landscape of cutaneous T-cell lymphoma.","authors":"Monaza Adeeb,&nbsp;Lubna Therachiyil,&nbsp;Safwan Moton,&nbsp;Joerg Buddenkotte,&nbsp;Majid Ali Alam,&nbsp;Shahab Uddin,&nbsp;Martin Steinhoff,&nbsp;Aamir Ahmad","doi":"10.1016/bs.ircmb.2023.04.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.04.004","url":null,"abstract":"<p><p>Cutaneous T-cell lymphoma (CTCL) is a type of cancer that affects skin, and is characterized by abnormal T-cells in the skin. Epigenetic changes have been found to play a significant role in the development and progression of CTCL. Recently, non-coding RNAs (ncRNAs), such as microRNAs and long non-coding RNAs, have been identified as key players in the regulation of gene expression in CTCL. These ncRNAs can alter the expression of genes involved in cell growth, differentiation, and apoptosis, leading to the development and progression of CTCL. In this review, we summarize the current understanding of the role of ncRNAs in CTCL, including their involvement in DNA methylation, and other biological processes. We also discuss the types of ncRNAs, their role as oncogenic or tumor suppressive, and their putative use as diagnostic and prognostic biomarkers, based on the emerging evidence from laboratory-based as well as patients-based studies. Moreover, we also present the potential targets and pathways affected by ncRNAs. A better understanding of the complex epigenetic landscape of CTCL, including the role of ncRNAs, has the potential to lead to the development of novel targeted therapies for this disease.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"380 ","pages":"149-171"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10159656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rational selection of an ideal oncolytic virus to address current limitations in clinical translation. 合理选择理想的溶瘤病毒以解决目前临床转译的局限性。
3区 生物学
International review of cell and molecular biology Pub Date : 2023-01-01 DOI: 10.1016/bs.ircmb.2023.03.004
Rupsa Basu, Chad M Moles
{"title":"Rational selection of an ideal oncolytic virus to address current limitations in clinical translation.","authors":"Rupsa Basu,&nbsp;Chad M Moles","doi":"10.1016/bs.ircmb.2023.03.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.03.004","url":null,"abstract":"<p><p>Oncolytic virus therapy (OVT) is a promising modality that leverages the propensity of natural or engineered viruses to selectively replicate in and kill cancer cells. Over the past decade, (pre)clinical studies have focused on the development and testing of adenovirus, herpes simplex virus, and vaccinia virus-based vectors. These studies have identified barriers to success confronting the field. Here, we propose a set of selection criteria or ideal properties of a successful oncolytic virus, which include lack of pathogenicity, low seroprevalence, selectivity (infection and replication), transgene carrying capacity, and genome stability. We use these requirements to analyze the oncolytic virus landscape, and then identify a potentially optimal species for platform development - vesicular stomatitis virus.</p>","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"379 ","pages":"241-261"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9948632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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