International review of cell and molecular biology最新文献_第6页

The key role of immunomodulatory cytokines for the development of novel NK cell-based cancer therapies. 免疫调节细胞因子在新型NK细胞为基础的癌症治疗发展中的关键作用。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-30 DOI: 10.1016/bs.ircmb.2025.01.007

Andrea Saez de Cámara, Diego Barriales, Anne Etxebarria, Cristina Eguizabal, Maite Alvarez

{"title":"The key role of immunomodulatory cytokines for the development of novel NK cell-based cancer therapies.","authors":"Andrea Saez de Cámara, Diego Barriales, Anne Etxebarria, Cristina Eguizabal, Maite Alvarez","doi":"10.1016/bs.ircmb.2025.01.007","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2025.01.007","url":null,"abstract":"Cytokines are crucial modulators of immune responses and have emerged as key components in cancer immunotherapy, particularly concerning Natural Killer (NK) cells. Indeed, the administration of these cytokines have demonstrated significant therapeutic potential in clinical settings. For instance, interleukin-2 (IL-2) has shown efficacy in melanoma and renal cell carcinoma, enhancing anti-tumor immunity but often associated with dose-limiting toxicities. IL-12 has been linked to improved survival rates in various solid tumors by stimulating Th1 responses and activating NK cells. Additionally, IL-15 has gained recognition for its ability to enhance NK cell proliferation and persistence, translating into favorable clinical outcomes in hematological malignancies such as acute myeloid leukemia (AML). Remarkably, cytokines can act synergistically providing stronger effects, and recent advancements have led to the identification of cytokine-induced memory-like NK (CIML-NK) cells. Despite these advancements, significant challenges persist in the translation of cytokine and NK cell therapies into routine clinical practice. The short half-life of recombinant cytokines poses limitations on their effectiveness, requiring high doses that can lead to severe side effects. Additionally, the complexities involved in the large-scale production of cytokines and the development of GMP-grade NK cell-therapies must be overcome. Innovative delivery systems, such as heterodimeric fusion proteins, oncolytic viruses and cytokine gene therapy, have emerged to address these issues, yet further research is needed to optimize these approaches. Collectively, this review underscores the importance of cytokines in harnessing the full potential of NK cells for cancer immunotherapy, and ongoing efforts that aim to optimize cytokine delivery strategies and enhance NK cell manufacturing processes.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"396 ","pages":"95-137"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

γδ T cells and head and neck squamous cell carcinoma. γδ T细胞与头颈部鳞状细胞癌的关系。

3区生物学

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-03-20 DOI: 10.1016/bs.ircmb.2025.03.005

Jiayu Peng, Hui Qiu, Lin-Lin Bu, Qiuji Wu

引用次数: 0

Role of chemokine receptors in transplant rejection and graft-versus-host disease. 趋化因子受体在移植排斥反应和移植物抗宿主疾病中的作用。

3区生物学

International review of cell and molecular biology Pub Date : 2024-08-15 DOI: 10.1016/bs.ircmb.2024.07.004

Paula Alonso-Guallart,David Harle

{"title":"Role of chemokine receptors in transplant rejection and graft-versus-host disease.","authors":"Paula Alonso-Guallart,David Harle","doi":"10.1016/bs.ircmb.2024.07.004","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.07.004","url":null,"abstract":"Organ transplantation increases life expectancy and improves the quality of life of patients experiencing specific conditions such as terminal organ failure. Despite matching efforts between donor and recipient, immune activation can interfere with allograft survival after transplantation if immunosuppression is not used. With both innate and adaptive responses, this is a complicated immunological process. This can lead to organ rejection, or graft-versus-host disease (GVHD), depending on the origin of the immune response. Inflammatory factors, such as chemokine receptors and their ligands, are involved in a wide variety of immunological processes, including modulating transplant rejection or GVHD, therefore, chemokine biology has been a major focus of transplantation studies. These molecules attract circulating peripheral leukocytes to infiltrate into the allograft and facilitate dendritic and T cell trafficking between lymph nodes and the graft during the allogeneic response. In this chapter, we will review the most relevant chemokine receptors such as CXCR3 and CCR5, among others, and their ligands involved in the process of allograft rejection for solid organ transplantation and graft-versus-host disease in the context of hematopoietic cell transplantation.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"8 1","pages":"95-123"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemokine receptors and their ligands in breast cancer: The key roles in progression and metastasis. 乳腺癌中的趋化因子受体及其配体：乳腺癌进展和转移中的关键作用。

3区生物学

International review of cell and molecular biology Pub Date : 2024-08-05 DOI: 10.1016/bs.ircmb.2024.07.002

Julio Valdivia-Silva,Alberto Chinney-Herrera

引用次数: 0

Role of chemokine receptors in gastrointestinal mucosa. 趋化因子受体在胃肠粘膜中的作用。

3区生物学

International review of cell and molecular biology Pub Date : 2024-05-31 DOI: 10.1016/bs.ircmb.2024.02.003

Brett Bell,Kevin Flores-Lovon,Luis A Cueva-Chicaña,Rodney Macedo

{"title":"Role of chemokine receptors in gastrointestinal mucosa.","authors":"Brett Bell,Kevin Flores-Lovon,Luis A Cueva-Chicaña,Rodney Macedo","doi":"10.1016/bs.ircmb.2024.02.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.02.003","url":null,"abstract":"Chemokine receptors are essential for the immune response in the oral and gut mucosa. The gastrointestinal mucosa is characterized by the presence of immune populations because it is susceptible to inflammatory and infectious diseases, necessitating immune surveillance. Chemokine receptors are expressed on immune cells and play a role in gastrointestinal tissue-homing, although other non-immune cells also express them for various biological functions. CCR9, CXCR3 and CXCR6 play an important role in the T cell response in inflammatory and neoplastic conditions of the gastrointestinal mucosa. However, CXCR6 could also be found in gastric cancer cells, highlighting the different roles of chemokine receptors in different pathologies. On the other hand, CCR4 and CCR8 are critical for Treg migration in gastrointestinal tissues, correlating with poor prognosis in mucosal cancers. Other chemokine receptors are also important in promoting myeloid infiltration with context-dependent roles. Further, CXCR4 and CXCR7 are also present in gastrointestinal tumor cells and are known to stimulate proliferation, migration, and invasion into other tissues, among other pro-tumorigenic functions. Determining the processes underlying mucosal immunity and creating tailored therapeutic approaches for gastrointestinal diseases requires an understanding of the complex interactions that occur between chemokine receptors and their ligands in these mucosal tissues.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"8 1","pages":"20-52"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemotactic signaling pathways in prostate cancer: Implications in the tumor microenvironment and as potential therapeutic targets. 前列腺癌的趋化信号通路：对肿瘤微环境的影响以及潜在的治疗靶点。

3区生物学

International review of cell and molecular biology Pub Date : 2024-05-06 DOI: 10.1016/bs.ircmb.2024.03.008

Zoila A Lopez-Bujanda,Shawn H Hadavi,Vicenç Ruiz De Porras,Eva Martínez-Balibrea,Matthew C Dallos

{"title":"Chemotactic signaling pathways in prostate cancer: Implications in the tumor microenvironment and as potential therapeutic targets.","authors":"Zoila A Lopez-Bujanda,Shawn H Hadavi,Vicenç Ruiz De Porras,Eva Martínez-Balibrea,Matthew C Dallos","doi":"10.1016/bs.ircmb.2024.03.008","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.03.008","url":null,"abstract":"Prostate cancer (PCa) stands as a significant global health concern, ranking among the leading causes of cancer deaths in men. While there are several treatment modalities for localized PCa, metastatic castration-resistant PCa (mCRPC) remains incurable. Despite therapeutic advancements showing promise in mCRPC, their impact on overall survival has been limited. This chapter explores the process by which tumors form, reviews our current understanding of PCa progression to mCRPC, and addresses the challenges of boosting anti-tumor immune responses in these tumors. It specifically discusses how chemotactic signaling affects the tumor microenvironment and its role in immune evasion and cancer progression. The chapter further examines the rationale of directly or indirectly targeting these pathways as adjuvant therapies for mCRPC, highlighting recent pre-clinical and clinical studies currently underway. The discussion emphasizes the potential of targeting specific chemokines and chemokine receptors as combination therapies with mainstream treatments for PCa and mCRPC to maximize long-term survival for this deadly disease.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"31 1","pages":"162-205"},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemokine receptors in primary and secondary lymphoid tissues. 原发性和继发性淋巴组织中的趋化因子受体。

3区生物学

International review of cell and molecular biology Pub Date : 2024-04-27 DOI: 10.1016/bs.ircmb.2023.11.003

Hector Cordero

{"title":"Chemokine receptors in primary and secondary lymphoid tissues.","authors":"Hector Cordero","doi":"10.1016/bs.ircmb.2023.11.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2023.11.003","url":null,"abstract":"Chemokine receptors are a complex superfamily of surface G protein-coupled receptors present mostly in leukocytes. In this chapter, we review the presence and functions of chemokine receptors in the immune cells of the primary and secondary lymphoid organs. Those include bone marrow, thymus, spleen, lymph nodes, and Peyer's patches as the main components of the gut-associated lymphoid tissue. There are general groups of chemokine receptors: conventional and atypical. We will mostly cover the role of conventional chemokine receptors, which are divided into four classes (CC, CXC, CX3C, and XC). Some relevant members are CXCR4, CXCR5, CCR4 and CCR7. For example, CXCR4 is a key chemokine receptor in the bone marrow controlling from the homing of progenitor cells into the bone marrow, the development of B cells, to the homing of long-lived plasma cells to this primary lymphoid organ. CCR7 and CCR4 are two of the main players in the thymus. CCR7 along with CCR9 control the traffic of thymic seed progenitors into the thymus, while CCR4 and CCR7 are critical for the entry of thymocytes into the medulla and as controllers of the central tolerance in the thymus. CXCR4 and CXCR5 have major roles in the spleen, guiding the maturation and class-switching of B cells in the different areas of the germinal center. In the T-cell zone, CCR7 guides the differentiation of naïve T cells. CCR7 also controls and directs the entry of T cells, B cells, and dendritic cells into secondary lymphoid tissues, including the spleen and lymph nodes. As new technologies emerge, techniques such as high dimensional spectral flow cytometry or single-cell sequencing allow a more comprehensive knowledge of the chemokine receptor network and their ligands, as well as the discovery of new interactions mediating unknown and overlooked mechanisms in health and disease.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"11 1","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic orchestration of the DNA damage response: Insights into the regulatory mechanisms. DNA 损伤反应的表观遗传协调：洞察调控机制

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-04-05 DOI: 10.1016/bs.ircmb.2024.03.003

Atanu Mondal, Agniswar Sarkar, Dipanwita Das, Amrita Sengupta, Aindrila Kabiraj, Payel Mondal, Rachayita Nag, Shravanti Mukherjee, Chandrima Das

{"title":"Epigenetic orchestration of the DNA damage response: Insights into the regulatory mechanisms.","authors":"Atanu Mondal, Agniswar Sarkar, Dipanwita Das, Amrita Sengupta, Aindrila Kabiraj, Payel Mondal, Rachayita Nag, Shravanti Mukherjee, Chandrima Das","doi":"10.1016/bs.ircmb.2024.03.003","DOIUrl":"https://doi.org/10.1016/bs.ircmb.2024.03.003","url":null,"abstract":"The DNA damage response (DDR) is a critical cellular mechanism that safeguards genome integrity and prevents the accumulation of harmful DNA lesions. Increasing evidence highlights the intersection between DDR signaling and epigenetic regulation, offering profound insights into various aspects of cellular function including oncogenesis. This comprehensive review explores the intricate relationship between the epigenetic modifications and DDR activation, with a specific focus on the impact of viral infections. Oncogenic viruses, such as human papillomavirus, hepatitis virus (HBV or HCV), and Epstein-Barr virus have been shown to activate the DDR. Consequently, these DNA damage events trigger a cascade of epigenetic alterations, including changes in DNA methylation patterns, histone modifications and the expression of noncoding RNAs. These epigenetic changes exert profound effects on chromatin structure, gene expression, and maintenance of genome stability. Importantly, elucidation of the viral-induced epigenetic alterations in the context of DDR holds significant implications for comprehending the complexity of cancer and provides potential targets for therapeutic interventions.","PeriodicalId":14422,"journal":{"name":"International review of cell and molecular biology","volume":"387 ","pages":"99-141"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation in ovarian cancer. 卵巢癌的表观遗传调控

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-05-13 DOI: 10.1016/bs.ircmb.2024.03.006

Hue Vu Thi, Anh-Dao Ngo, Dinh-Toi Chu

引用次数: 0

Epigenetic regulation of cancer. 癌症的表观遗传调控。

3区生物学

International review of cell and molecular biology Pub Date : 2024-01-01 Epub Date: 2024-02-13 DOI: 10.1016/S1937-6448(24)00026-1

Sheila Spada, Lorenzo Galluzzi

引用次数: 0